ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	short-term memory (GO:0007614)	9.04763260
2	mitochondrion distribution (GO:0048311)	7.55304553
3	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	7.46630698
4	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	6.86758991
5	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	6.86758991
6	specification of organ identity (GO:0010092)	6.84909246
7	regulation of penile erection (GO:0060405)	6.12199715
8	prenylation (GO:0097354)	6.08380626
9	protein prenylation (GO:0018342)	6.08380626
10	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	5.84886274
11	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	5.58113185
12	behavioral response to ethanol (GO:0048149)	5.56314049
13	hindbrain development (GO:0030902)	5.52947981
14	adaptation of signaling pathway (GO:0023058)	5.42573070
15	response to histamine (GO:0034776)	5.35792185
16	mitochondrion localization (GO:0051646)	5.11247668
17	behavioral response to cocaine (GO:0048148)	4.99510489
18	regulation of neurotransmitter uptake (GO:0051580)	4.89851710
19	synaptic transmission, dopaminergic (GO:0001963)	4.77375196
20	artery smooth muscle contraction (GO:0014824)	4.71590016
21	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	4.67037697
22	mitochondrion transport along microtubule (GO:0047497)	4.67037697
23	positive regulation of sodium ion transmembrane transport (GO:1902307)	4.62757754
24	chemosensory behavior (GO:0007635)	4.50401307
25	regulation of systemic arterial blood pressure (GO:0003073)	4.46686186
26	establishment of mitochondrion localization (GO:0051654)	4.35068578
27	protein targeting to Golgi (GO:0000042)	4.31050448
28	neurofilament cytoskeleton organization (GO:0060052)	4.24825223
29	pyrimidine nucleobase catabolic process (GO:0006208)	4.24582702
30	tonic smooth muscle contraction (GO:0014820)	4.11792271
31	cell fate commitment involved in formation of primary germ layer (GO:0060795)	4.11636364
32	icosanoid secretion (GO:0032309)	4.08433680
33	arachidonic acid secretion (GO:0050482)	4.08433680
34	regulation of voltage-gated calcium channel activity (GO:1901385)	4.04731238
35	establishment of protein localization to Golgi (GO:0072600)	3.99023515
36	positive regulation of RNA splicing (GO:0033120)	3.97157403
37	RNA destabilization (GO:0050779)	3.90384514
38	regulation of synaptic transmission, dopaminergic (GO:0032225)	3.85673386
39	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.81506068
40	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.76492189
41	NADH dehydrogenase complex assembly (GO:0010257)	3.76492189
42	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.76492189
43	negative regulation of response to food (GO:0032096)	3.75003026
44	negative regulation of appetite (GO:0032099)	3.75003026
45	positive regulation of neurotransmitter transport (GO:0051590)	3.69856775
46	phasic smooth muscle contraction (GO:0014821)	3.65968237
47	regulation of proton transport (GO:0010155)	3.63867058
48	nucleobase catabolic process (GO:0046113)	3.59569004
49	regulation of dopamine metabolic process (GO:0042053)	3.54738400
50	regulation of catecholamine metabolic process (GO:0042069)	3.54738400
51	positive regulation of histone H3-K4 methylation (GO:0051571)	3.48683659
52	response to misfolded protein (GO:0051788)	3.43743175
53	positive regulation of mRNA processing (GO:0050685)	3.42204843
54	histone H3-K4 trimethylation (GO:0080182)	3.40081638
55	protein complex biogenesis (GO:0070271)	3.38948591
56	positive regulation of oligodendrocyte differentiation (GO:0048714)	3.38827036
57	positive regulation of cell size (GO:0045793)	3.35802743
58	positive regulation of amine transport (GO:0051954)	3.34078639
59	retina development in camera-type eye (GO:0060041)	3.28456712
60	negative regulation of cAMP biosynthetic process (GO:0030818)	3.26485916
61	cell proliferation in forebrain (GO:0021846)	3.25497463
62	axonal fasciculation (GO:0007413)	3.23315756
63	multicellular organism reproduction (GO:0032504)	3.22793301
64	negative regulation of cation channel activity (GO:2001258)	3.20114939
65	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	3.14639333
66	negative regulation of cyclic nucleotide biosynthetic process (GO:0030803)	3.13517608
67	tachykinin receptor signaling pathway (GO:0007217)	3.13340161
68	mitochondrial respiratory chain complex assembly (GO:0033108)	3.09467962
69	fatty acid derivative transport (GO:1901571)	3.08947284
70	icosanoid transport (GO:0071715)	3.08947284
71	protein localization to Golgi apparatus (GO:0034067)	3.08692072
72	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	3.08640728
73	behavioral fear response (GO:0001662)	3.07099242
74	behavioral defense response (GO:0002209)	3.07099242
75	negative regulation of adenylate cyclase activity (GO:0007194)	3.02311841
76	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.00020309
77	substrate-independent telencephalic tangential migration (GO:0021826)	3.00020309
78	regulation of feeding behavior (GO:0060259)	2.95192358
79	negative regulation of cAMP metabolic process (GO:0030815)	2.94491082
80	negative regulation of purine nucleotide biosynthetic process (GO:1900372)	2.91567195
81	negative regulation of nucleotide biosynthetic process (GO:0030809)	2.91567195
82	misfolded or incompletely synthesized protein catabolic process (GO:0006515)	2.90467206
83	negative regulation of mast cell activation (GO:0033004)	2.90448403
84	vascular smooth muscle contraction (GO:0014829)	2.87266947
85	dopamine receptor signaling pathway (GO:0007212)	2.87173731
86	negative regulation of cyclase activity (GO:0031280)	2.86028017
87	establishment of melanosome localization (GO:0032401)	2.83838623
88	negative regulation of cyclic nucleotide metabolic process (GO:0030800)	2.83548482
89	somite development (GO:0061053)	2.83341787
90	regulation of sodium ion transmembrane transporter activity (GO:2000649)	2.83095467
91	negative regulation of lyase activity (GO:0051350)	2.81855548
92	positive regulation of sodium ion transport (GO:0010765)	2.80908881
93	hippocampus development (GO:0021766)	2.78761902
94	establishment of pigment granule localization (GO:0051905)	2.77896216
95	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.77763031
96	ubiquinone metabolic process (GO:0006743)	2.77684799
97	melanosome transport (GO:0032402)	2.77531161
98	ubiquinone biosynthetic process (GO:0006744)	2.75818890
99	nonmotile primary cilium assembly (GO:0035058)	2.71784460
100	pigment granule transport (GO:0051904)	2.71605348

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	6.68181889
2	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.82578349
3	EZH2_22144423_ChIP-Seq_EOC_Human	2.69918228
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.64956509
5	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.63241981
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.42989425
7	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.38616018
8	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.28434116
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.21559905
10	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.18485591
11	GBX2_23144817_ChIP-Seq_PC3_Human	2.15302547
12	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.14290723
13	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.14095411
14	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.09245531
15	VDR_22108803_ChIP-Seq_LS180_Human	2.09028677
16	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.04454968
17	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.97469038
18	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.93386626
19	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.91865656
20	REST_21632747_ChIP-Seq_MESCs_Mouse	1.90704173
21	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.89044186
22	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.85960745
23	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.78581664
24	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.76777199
25	RNF2_27304074_Chip-Seq_NSC_Mouse	1.73653526
26	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.73450245
27	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.72400530
28	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.71659270
29	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.66113068
30	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.65601628
31	P300_19829295_ChIP-Seq_ESCs_Human	1.63752046
32	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.59611535
33	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.57911185
34	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.57273822
35	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.54036247
36	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.53795461
37	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.48294148
38	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.47776397
39	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.47422867
40	BCAT_22108803_ChIP-Seq_LS180_Human	1.46949995
41	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.42521081
42	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.41628123
43	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.40716951
44	ELK1_19687146_ChIP-ChIP_HELA_Human	1.38456003
45	TAF15_26573619_Chip-Seq_HEK293_Human	1.37252503
46	AR_25329375_ChIP-Seq_VCAP_Human	1.37147986
47	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.35539166
48	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.31369611
49	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.29108383
50	NCOR_22424771_ChIP-Seq_293T_Human	1.27503451
51	SMAD4_21799915_ChIP-Seq_A2780_Human	1.27489177
52	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.24900813
53	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.24900813
54	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.23004191
55	FUS_26573619_Chip-Seq_HEK293_Human	1.22304400
56	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.21806946
57	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.21031026
58	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.20875202
59	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.20634991
60	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.18892961
61	JUN_21703547_ChIP-Seq_K562_Human	1.18714585
62	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.18457546
63	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.18381832
64	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.18147743
65	RUNX2_22187159_ChIP-Seq_PCA_Human	1.17566880
66	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.17067862
67	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.16133300
68	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.15283199
69	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.14013023
70	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.12950930
71	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.12950930
72	TCF4_22108803_ChIP-Seq_LS180_Human	1.12862064
73	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.12328183
74	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.12043386
75	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.11185529
76	ER_23166858_ChIP-Seq_MCF-7_Human	1.11094288
77	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.09708213
78	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.09693998
79	STAT3_23295773_ChIP-Seq_U87_Human	1.09644084
80	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.09592366
81	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.04348486
82	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.03316611
83	STAT1_17558387_ChIP-Seq_HELA_Human	1.02080237
84	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.01507491
85	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.01334557
86	IRF1_19129219_ChIP-ChIP_H3396_Human	1.00856839
87	ERA_21632823_ChIP-Seq_H3396_Human	1.00224398
88	TP53_22573176_ChIP-Seq_HFKS_Human	0.99397155
89	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.99317961
90	IGF1R_20145208_ChIP-Seq_DFB_Human	0.98746711
91	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.96916304
92	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.96862698
93	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.96781838
94	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.96060844
95	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.95959220
96	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.95441084
97	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.93735345
98	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.92874278
99	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.90178766
100	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.89358288

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005423_abnormal_somatic_nervous	3.18984644
2	MP0001905_abnormal_dopamine_level	3.03060729
3	MP0002638_abnormal_pupillary_reflex	2.90266125
4	MP0003880_abnormal_central_pattern	2.82515689
5	MP0003787_abnormal_imprinting	2.81141888
6	MP0004859_abnormal_synaptic_plasticity	2.68630788
7	MP0000462_abnormal_digestive_system	2.67726669
8	MP0008877_abnormal_DNA_methylation	2.44936360
9	MP0003122_maternal_imprinting	2.33250054
10	MP0002837_dystrophic_cardiac_calcinosis	2.08924560
11	MP0002272_abnormal_nervous_system	2.01780754
12	MP0009046_muscle_twitch	2.01239641
13	MP0006276_abnormal_autonomic_nervous	1.98757570
14	MP0004885_abnormal_endolymph	1.97954754
15	MP0002572_abnormal_emotion/affect_behav	1.94362633
16	MP0000778_abnormal_nervous_system	1.86819409
17	MP0002233_abnormal_nose_morphology	1.86361512
18	MP0005551_abnormal_eye_electrophysiolog	1.82072499
19	MP0001293_anophthalmia	1.81519332
20	MP0005167_abnormal_blood-brain_barrier	1.80615876
21	MP0000955_abnormal_spinal_cord	1.77754884
22	MP0004133_heterotaxia	1.73971960
23	MP0002733_abnormal_thermal_nociception	1.72850989
24	MP0001529_abnormal_vocalization	1.72068489
25	MP0004147_increased_porphyrin_level	1.69682539
26	MP0008775_abnormal_heart_ventricle	1.68225762
27	MP0009745_abnormal_behavioral_response	1.66128468
28	MP0002139_abnormal_hepatobiliary_system	1.66032516
29	MP0005083_abnormal_biliary_tract	1.65916511
30	MP0006292_abnormal_olfactory_placode	1.60670950
31	MP0002063_abnormal_learning/memory/cond	1.57144296
32	MP0003283_abnormal_digestive_organ	1.56962532
33	MP0004142_abnormal_muscle_tone	1.55498963
34	MP0002752_abnormal_somatic_nervous	1.52930116
35	MP0002102_abnormal_ear_morphology	1.52044986
36	MP0001486_abnormal_startle_reflex	1.51479199
37	MP0005379_endocrine/exocrine_gland_phen	1.50563879
38	MP0003635_abnormal_synaptic_transmissio	1.43121576
39	MP0002734_abnormal_mechanical_nocicepti	1.42484279
40	MP0006072_abnormal_retinal_apoptosis	1.41198514
41	MP0002067_abnormal_sensory_capabilities	1.38108834
42	MP0002928_abnormal_bile_duct	1.37835131
43	MP0003121_genomic_imprinting	1.37456350
44	MP0005084_abnormal_gallbladder_morpholo	1.37162598
45	MP0002332_abnormal_exercise_endurance	1.37068916
46	MP0002882_abnormal_neuron_morphology	1.35450037
47	MP0005645_abnormal_hypothalamus_physiol	1.35400075
48	MP0002557_abnormal_social/conspecific_i	1.34342209
49	MP0001970_abnormal_pain_threshold	1.28902869
50	MP0005253_abnormal_eye_physiology	1.28704832
51	MP0008789_abnormal_olfactory_epithelium	1.27610539
52	MP0002184_abnormal_innervation	1.26847574
53	MP0003252_abnormal_bile_duct	1.25180073
54	MP0002909_abnormal_adrenal_gland	1.24884885
55	MP0003191_abnormal_cellular_cholesterol	1.22640862
56	MP0001299_abnormal_eye_distance/	1.22284772
57	MP0005195_abnormal_posterior_eye	1.22080993
58	MP0002069_abnormal_eating/drinking_beha	1.21310420
59	MP0002653_abnormal_ependyma_morphology	1.18865055
60	MP0001485_abnormal_pinna_reflex	1.18683652
61	MP0006035_abnormal_mitochondrial_morpho	1.15084405
62	MP0006054_spinal_hemorrhage	1.13158838
63	MP0002735_abnormal_chemical_nociception	1.12433656
64	MP0002152_abnormal_brain_morphology	1.12022680
65	MP0003329_amyloid_beta_deposits	1.11626380
66	MP0002064_seizures	1.11535908
67	MP0005410_abnormal_fertilization	1.10127129
68	MP0005386_behavior/neurological_phenoty	1.09873975
69	MP0004924_abnormal_behavior	1.09873975
70	MP0003879_abnormal_hair_cell	1.04357941
71	MP0004270_analgesia	1.02080419
72	MP0005075_abnormal_melanosome_morpholog	0.96558858
73	MP0000049_abnormal_middle_ear	0.96117806
74	MP0002822_catalepsy	0.95797543
75	MP0000631_abnormal_neuroendocrine_gland	0.95244310
76	MP0005394_taste/olfaction_phenotype	0.94929699
77	MP0005499_abnormal_olfactory_system	0.94929699
78	MP0002229_neurodegeneration	0.94845409
79	MP0002163_abnormal_gland_morphology	0.94512103
80	MP0002234_abnormal_pharynx_morphology	0.94421912
81	MP0003195_calcinosis	0.93534852
82	MP0002066_abnormal_motor_capabilities/c	0.92980091
83	MP0010386_abnormal_urinary_bladder	0.90482649
84	MP0000026_abnormal_inner_ear	0.90323754
85	MP0003633_abnormal_nervous_system	0.88647628
86	MP0001440_abnormal_grooming_behavior	0.88406628
87	MP0004742_abnormal_vestibular_system	0.88198668
88	MP0002277_abnormal_respiratory_mucosa	0.86851927
89	MP0005266_abnormal_metabolism	0.86019158
90	MP0000747_muscle_weakness	0.85826380
91	MP0004811_abnormal_neuron_physiology	0.85791332
92	MP0005391_vision/eye_phenotype	0.85194820
93	MP0008961_abnormal_basal_metabolism	0.82838485
94	MP0000427_abnormal_hair_cycle	0.80133558
95	MP0002751_abnormal_autonomic_nervous	0.79896084
96	MP0003806_abnormal_nucleotide_metabolis	0.79057054
97	MP0001984_abnormal_olfaction	0.78941112
98	MP0001324_abnormal_eye_pigmentation	0.78710943
99	MP0001968_abnormal_touch/_nociception	0.77714945
100	MP0004145_abnormal_muscle_electrophysio	0.74520249

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Tongue fasciculations (HP:0001308)	4.97054713
2	Fetal akinesia sequence (HP:0001989)	4.83630667
3	Muscle fibrillation (HP:0010546)	4.30083883
4	Submucous cleft hard palate (HP:0000176)	4.08438952
5	Esotropia (HP:0000565)	3.91942150
6	Gait imbalance (HP:0002141)	3.87009641
7	Congenital stationary night blindness (HP:0007642)	3.77418690
8	Medial flaring of the eyebrow (HP:0010747)	3.75279558
9	Methylmalonic acidemia (HP:0002912)	3.60903636
10	Acute necrotizing encephalopathy (HP:0006965)	3.46057006
11	Severe muscular hypotonia (HP:0006829)	3.42945123
12	Retinal atrophy (HP:0001105)	3.37407742
13	Rib fusion (HP:0000902)	3.29009835
14	Nephrogenic diabetes insipidus (HP:0009806)	3.26209601
15	Pachygyria (HP:0001302)	3.17658993
16	Abnormal rod and cone electroretinograms (HP:0008323)	3.13807881
17	Congenital primary aphakia (HP:0007707)	3.11046161
18	Myokymia (HP:0002411)	3.06597383
19	Abnormal mitochondria in muscle tissue (HP:0008316)	3.05260000
20	Increased CSF lactate (HP:0002490)	3.05103440
21	Molar tooth sign on MRI (HP:0002419)	3.02022880
22	Abnormality of midbrain morphology (HP:0002418)	3.02022880
23	Shawl scrotum (HP:0000049)	2.96204993
24	Renal dysplasia (HP:0000110)	2.90242501
25	Progressive macrocephaly (HP:0004481)	2.88800657
26	Retinal dysplasia (HP:0007973)	2.87612216
27	Lissencephaly (HP:0001339)	2.87572966
28	Abnormality of the corticospinal tract (HP:0002492)	2.86294721
29	Acute encephalopathy (HP:0006846)	2.79814028
30	Limb dystonia (HP:0002451)	2.75842521
31	Nephronophthisis (HP:0000090)	2.72075846
32	Chronic hepatic failure (HP:0100626)	2.68598929
33	Action tremor (HP:0002345)	2.68243985
34	Drooling (HP:0002307)	2.63075941
35	Abnormal hair whorl (HP:0010721)	2.60170302
36	Amyotrophic lateral sclerosis (HP:0007354)	2.59866109
37	Abnormality of the renal cortex (HP:0011035)	2.55204988
38	Methylmalonic aciduria (HP:0012120)	2.54829468
39	Mitochondrial inheritance (HP:0001427)	2.49729868
40	Tubular atrophy (HP:0000092)	2.44074738
41	Pancreatic fibrosis (HP:0100732)	2.42176045
42	Excessive salivation (HP:0003781)	2.39314826
43	Genital tract atresia (HP:0001827)	2.38977577
44	Hypogonadotrophic hypogonadism (HP:0000044)	2.36692888
45	Vaginal atresia (HP:0000148)	2.35914646
46	Proximal tubulopathy (HP:0000114)	2.35038908
47	Poor coordination (HP:0002370)	2.34574398
48	Neonatal hypoglycemia (HP:0001998)	2.34305394
49	Pancreatic cysts (HP:0001737)	2.34264545
50	Left ventricular hypertrophy (HP:0001712)	2.30775216
51	Abnormality of the renal medulla (HP:0100957)	2.30131633
52	Tented upper lip vermilion (HP:0010804)	2.29712071
53	Polyphagia (HP:0002591)	2.27428143
54	EEG with generalized epileptiform discharges (HP:0011198)	2.26755007
55	Tubulointerstitial fibrosis (HP:0005576)	2.25322421
56	Poor suck (HP:0002033)	2.25261935
57	Hypsarrhythmia (HP:0002521)	2.23464359
58	Epileptiform EEG discharges (HP:0011182)	2.22569038
59	Hepatic necrosis (HP:0002605)	2.20738715
60	Hepatocellular necrosis (HP:0001404)	2.15423473
61	Spastic tetraplegia (HP:0002510)	2.13634351
62	Renal tubular acidosis (HP:0001947)	2.11779953
63	Aplasia/Hypoplasia of the brainstem (HP:0007362)	2.11530247
64	Hypoplasia of the brainstem (HP:0002365)	2.11530247
65	Agitation (HP:0000713)	2.10066793
66	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.09173075
67	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.09173075
68	Intestinal atresia (HP:0011100)	2.08965768
69	Mutism (HP:0002300)	2.08591292
70	Absent speech (HP:0001344)	2.07098948
71	Abnormal number of incisors (HP:0011064)	2.05912064
72	Abnormality of vitamin B metabolism (HP:0004340)	2.04888466
73	Anencephaly (HP:0002323)	2.03633507
74	Specific learning disability (HP:0001328)	2.02106931
75	Ulnar claw (HP:0001178)	2.01873404
76	Broad-based gait (HP:0002136)	2.00896934
77	Poor eye contact (HP:0000817)	2.00247642
78	Cerebral edema (HP:0002181)	1.98433348
79	Inability to walk (HP:0002540)	1.96191244
80	CNS hypomyelination (HP:0003429)	1.96025796
81	White forelock (HP:0002211)	1.93916696
82	Increased serum lactate (HP:0002151)	1.93860483
83	Absent/shortened dynein arms (HP:0200106)	1.92509226
84	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.92509226
85	Hypothermia (HP:0002045)	1.89119844
86	Progressive inability to walk (HP:0002505)	1.86377151
87	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.86197716
88	Testicular atrophy (HP:0000029)	1.85272198
89	Hand muscle atrophy (HP:0009130)	1.85045954
90	Atrophy/Degeneration involving motor neurons (HP:0007373)	1.85039766
91	Aplasia/Hypoplasia of the lens (HP:0008063)	1.82228106
92	Large earlobe (HP:0009748)	1.80887997
93	Type II lissencephaly (HP:0007260)	1.80267272
94	Decreased muscle mass (HP:0003199)	1.78846678
95	Lactic acidosis (HP:0003128)	1.77438443
96	Renal tubular dysfunction (HP:0000124)	1.76743580
97	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.76676471
98	Hyperglycinemia (HP:0002154)	1.75872769
99	Adrenal hypoplasia (HP:0000835)	1.75835831
100	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.75441924

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PRPF4B	8.03989687
2	TAOK2	5.94146184
3	MAP4K2	3.19310236
4	CDK19	2.88802957
5	GRK1	2.84653014
6	ADRBK2	2.79573716
7	BMPR1B	2.37076429
8	MARK1	2.21424410
9	TYRO3	2.06035051
10	MAP3K12	1.90375270
11	CDK8	1.89291470
12	FRK	1.80930164
13	TAOK1	1.79731114
14	EPHA4	1.78648623
15	PHKG1	1.73117037
16	PHKG2	1.73117037
17	PNCK	1.65636359
18	MKNK2	1.62151082
19	DYRK2	1.58476666
20	OXSR1	1.57641196
21	INSRR	1.52527449
22	MAPK13	1.51457658
23	MARK2	1.36702811
24	MINK1	1.31908134
25	TIE1	1.27725609
26	CSNK1G3	1.18884074
27	CSNK1G1	1.17680650
28	IRAK3	1.16291609
29	CSNK1G2	1.15560949
30	ILK	1.14698601
31	MAPKAPK3	1.11862302
32	PRKCG	1.11497904
33	PKN1	1.09116323
34	MAP2K7	1.06626778
35	TRIM28	1.06582128
36	EPHB2	1.05367054
37	WNK3	1.01383211
38	MAP3K4	0.99891250
39	TGFBR1	0.86062673
40	PLK2	0.84576520
41	CAMK1G	0.84416286
42	GRK7	0.84209217
43	RPS6KA5	0.84062120
44	ABL2	0.82638078
45	NTRK3	0.81346376
46	STK16	0.75311729
47	CSNK1A1L	0.73695758
48	PRKCI	0.73382612
49	CSNK1E	0.70129289
50	PRKCE	0.69859087
51	LIMK1	0.69684378
52	CSNK1A1	0.68585883
53	MYLK	0.65244594
54	SGK223	0.62141070
55	SGK494	0.62141070
56	TRPM7	0.60469372
57	PRKAA1	0.59708189
58	DAPK2	0.57546076
59	ADRBK1	0.54431429
60	STK11	0.54129313
61	PINK1	0.53572261
62	PIK3CG	0.50776278
63	MKNK1	0.48690635
64	BCR	0.48153111
65	PRKG1	0.45967228
66	FER	0.44880946
67	PAK3	0.42724281
68	MAP2K6	0.41098832
69	EIF2AK3	0.39807224
70	NME1	0.39242292
71	CASK	0.38471783
72	CAMK2A	0.37862616
73	RPS6KA2	0.37493492
74	PRKCH	0.36808276
75	MAP2K4	0.35134110
76	SRPK1	0.34374994
77	PRKD2	0.34370577
78	CAMK1D	0.34201880
79	STK24	0.33315157
80	RPS6KB2	0.31361278
81	TSSK6	0.31020878
82	ERBB3	0.30978636
83	EEF2K	0.29136636
84	CAMK1	0.28729099
85	PTK2B	0.27661085
86	PRKCZ	0.27380067
87	TAF1	0.27252946
88	MAPK12	0.26210937
89	CSNK2A2	0.26037041
90	PRKCA	0.25680959
91	ROCK1	0.24469730
92	AURKA	0.24460389
93	CSNK1D	0.24034341
94	NTRK2	0.23612433
95	CHEK2	0.23503638
96	DMPK	0.23296505
97	MST4	0.22840756
98	MAPK9	0.22797157
99	CLK1	0.20733568
100	PRKACA	0.20619417

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	3.93879313
2	Protein export_Homo sapiens_hsa03060	3.00882062
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.95843910
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.93836664
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.81566579
6	Phototransduction_Homo sapiens_hsa04744	2.74748586
7	Collecting duct acid secretion_Homo sapiens_hsa04966	2.62419009
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.43105245
9	Parkinsons disease_Homo sapiens_hsa05012	2.32173596
10	Dopaminergic synapse_Homo sapiens_hsa04728	2.02429143
11	Folate biosynthesis_Homo sapiens_hsa00790	1.93771818
12	Selenocompound metabolism_Homo sapiens_hsa00450	1.87505491
13	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.85824958
14	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.81719244
15	Butanoate metabolism_Homo sapiens_hsa00650	1.63716165
16	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.57857190
17	Bile secretion_Homo sapiens_hsa04976	1.56987613
18	Peroxisome_Homo sapiens_hsa04146	1.55219576
19	Alzheimers disease_Homo sapiens_hsa05010	1.53718510
20	Insulin secretion_Homo sapiens_hsa04911	1.46310695
21	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.45549426
22	Cardiac muscle contraction_Homo sapiens_hsa04260	1.44540897
23	Sulfur metabolism_Homo sapiens_hsa00920	1.42669936
24	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.39420052
25	Vibrio cholerae infection_Homo sapiens_hsa05110	1.38470849
26	Huntingtons disease_Homo sapiens_hsa05016	1.34390661
27	Nicotine addiction_Homo sapiens_hsa05033	1.33174917
28	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.30597531
29	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.29489119
30	GABAergic synapse_Homo sapiens_hsa04727	1.28007982
31	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.27536591
32	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.26330295
33	Propanoate metabolism_Homo sapiens_hsa00640	1.24726988
34	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.24611101
35	Basal transcription factors_Homo sapiens_hsa03022	1.20030865
36	Tryptophan metabolism_Homo sapiens_hsa00380	1.19227352
37	Fatty acid degradation_Homo sapiens_hsa00071	1.14824230
38	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.13814713
39	ABC transporters_Homo sapiens_hsa02010	1.13466471
40	Hippo signaling pathway_Homo sapiens_hsa04390	1.08907214
41	Regulation of autophagy_Homo sapiens_hsa04140	1.04357730
42	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.03510701
43	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.03201820
44	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.01378439
45	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.01128447
46	Axon guidance_Homo sapiens_hsa04360	0.99577242
47	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.97968725
48	Fatty acid metabolism_Homo sapiens_hsa01212	0.96914424
49	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.95520632
50	Morphine addiction_Homo sapiens_hsa05032	0.93834546
51	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.93528319
52	ErbB signaling pathway_Homo sapiens_hsa04012	0.92055226
53	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.91582164
54	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.90637307
55	Chemical carcinogenesis_Homo sapiens_hsa05204	0.82145228
56	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.79017922
57	Fatty acid elongation_Homo sapiens_hsa00062	0.77303872
58	Olfactory transduction_Homo sapiens_hsa04740	0.74170223
59	Glutamatergic synapse_Homo sapiens_hsa04724	0.72554143
60	Circadian entrainment_Homo sapiens_hsa04713	0.71196686
61	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.70728148
62	Steroid biosynthesis_Homo sapiens_hsa00100	0.70027219
63	Ribosome_Homo sapiens_hsa03010	0.69164725
64	Tight junction_Homo sapiens_hsa04530	0.67026833
65	Lysine degradation_Homo sapiens_hsa00310	0.66887187
66	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.66872566
67	Retinol metabolism_Homo sapiens_hsa00830	0.65460975
68	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.63666955
69	Taste transduction_Homo sapiens_hsa04742	0.63660918
70	Ras signaling pathway_Homo sapiens_hsa04014	0.63004337
71	RNA degradation_Homo sapiens_hsa03018	0.62687512
72	Prion diseases_Homo sapiens_hsa05020	0.62113165
73	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.59812163
74	Gastric acid secretion_Homo sapiens_hsa04971	0.56264785
75	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.55658400
76	Proteasome_Homo sapiens_hsa03050	0.55071171
77	Metabolic pathways_Homo sapiens_hsa01100	0.53134614
78	Sulfur relay system_Homo sapiens_hsa04122	0.51148283
79	RNA polymerase_Homo sapiens_hsa03020	0.49919810
80	Serotonergic synapse_Homo sapiens_hsa04726	0.49705502
81	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.47093846
82	Nitrogen metabolism_Homo sapiens_hsa00910	0.46489643
83	Melanoma_Homo sapiens_hsa05218	0.43951499
84	Histidine metabolism_Homo sapiens_hsa00340	0.43901106
85	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.43000288
86	Purine metabolism_Homo sapiens_hsa00230	0.41507831
87	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.40201669
88	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.39858014
89	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.38023574
90	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.37963806
91	beta-Alanine metabolism_Homo sapiens_hsa00410	0.37902577
92	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.36631385
93	p53 signaling pathway_Homo sapiens_hsa04115	0.36492650
94	Rap1 signaling pathway_Homo sapiens_hsa04015	0.35173994
95	Pyruvate metabolism_Homo sapiens_hsa00620	0.34842598
96	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.34793456
97	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.34507135
98	Cholinergic synapse_Homo sapiens_hsa04725	0.34250242
99	Salivary secretion_Homo sapiens_hsa04970	0.34132723
100	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.33968454

BTBD10P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »