BTBD11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1dopamine transport (GO:0015872)6.74265017
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.02332000
3vocalization behavior (GO:0071625)5.93170481
4neuron cell-cell adhesion (GO:0007158)5.31224629
5dopamine biosynthetic process (GO:0042416)5.25913662
6synaptic vesicle exocytosis (GO:0016079)5.25562285
7neurotransmitter secretion (GO:0007269)5.00768849
8catecholamine transport (GO:0051937)4.93940463
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.69075984
10locomotory exploration behavior (GO:0035641)4.64510265
11synaptic vesicle maturation (GO:0016188)4.61842769
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.54438182
13gamma-aminobutyric acid transport (GO:0015812)4.52337566
14glutamate secretion (GO:0014047)4.50902400
15regulation of glutamate receptor signaling pathway (GO:1900449)4.50889103
16negative regulation of synaptic transmission, GABAergic (GO:0032229)4.42237743
17positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.39171707
18regulation of synaptic vesicle exocytosis (GO:2000300)4.38206781
19protein localization to synapse (GO:0035418)4.36725381
20proline transport (GO:0015824)4.34738141
21regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.34159650
22postsynaptic membrane organization (GO:0001941)4.14426395
23tolerance induction (GO:0002507)4.13721831
24neuronal action potential propagation (GO:0019227)4.06568344
25neurotransmitter transport (GO:0006836)4.06299917
26exploration behavior (GO:0035640)4.00949428
27cerebellar Purkinje cell differentiation (GO:0021702)3.99632532
28ionotropic glutamate receptor signaling pathway (GO:0035235)3.93031866
29layer formation in cerebral cortex (GO:0021819)3.92394352
30behavioral response to nicotine (GO:0035095)3.91746261
31regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.89734849
32protein polyglutamylation (GO:0018095)3.89030766
33regulation of long-term neuronal synaptic plasticity (GO:0048169)3.80154688
34activated T cell proliferation (GO:0050798)3.79671281
35gamma-aminobutyric acid signaling pathway (GO:0007214)3.78224675
36neuron recognition (GO:0008038)3.77863071
37regulation of synaptic vesicle transport (GO:1902803)3.75653536
38positive regulation of synapse maturation (GO:0090129)3.69048823
39regulation of neurotransmitter levels (GO:0001505)3.69016621
40neurotransmitter-gated ion channel clustering (GO:0072578)3.67793472
41neuron-neuron synaptic transmission (GO:0007270)3.67131228
42synaptic vesicle docking involved in exocytosis (GO:0016081)3.65895833
43regulation of neuronal synaptic plasticity (GO:0048168)3.61121590
44protein K11-linked deubiquitination (GO:0035871)3.60329385
45startle response (GO:0001964)3.58568985
46positive regulation of synapse assembly (GO:0051965)3.58237603
47histone H3-K36 demethylation (GO:0070544)3.57272311
48regulation of synaptic transmission, GABAergic (GO:0032228)3.55815722
49regulation of cilium movement (GO:0003352)3.55614323
50transmission of nerve impulse (GO:0019226)3.55283866
51dendritic spine morphogenesis (GO:0060997)3.53710691
52glutamate receptor signaling pathway (GO:0007215)3.53147406
53negative T cell selection (GO:0043383)3.52645128
54synaptic transmission, glutamatergic (GO:0035249)3.51762912
55fucose catabolic process (GO:0019317)3.50126311
56L-fucose metabolic process (GO:0042354)3.50126311
57L-fucose catabolic process (GO:0042355)3.50126311
58axonal fasciculation (GO:0007413)3.47693519
59neuromuscular process controlling posture (GO:0050884)3.47483622
60positive regulation of synaptic transmission, GABAergic (GO:0032230)3.37789651
61negative regulation of neurotransmitter transport (GO:0051589)3.35937760
62synaptic vesicle endocytosis (GO:0048488)3.35518557
63negative thymic T cell selection (GO:0045060)3.33602532
64response to histamine (GO:0034776)3.31231587
65keratinization (GO:0031424)3.30716019
66synapse assembly (GO:0007416)3.30619070
67mast cell activation involved in immune response (GO:0002279)3.28995704
68mast cell degranulation (GO:0043303)3.28995704
69monoamine transport (GO:0015844)3.28540706
70negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.28183795
71negative regulation of translation, ncRNA-mediated (GO:0040033)3.28183795
72regulation of translation, ncRNA-mediated (GO:0045974)3.28183795
73long-term memory (GO:0007616)3.27479049
74cell migration in hindbrain (GO:0021535)3.26575711
75keratinocyte development (GO:0003334)3.24487717
76catecholamine biosynthetic process (GO:0042423)3.24446217
77catechol-containing compound biosynthetic process (GO:0009713)3.24446217
78striatum development (GO:0021756)3.22478923
79positive T cell selection (GO:0043368)3.20353883
80neuromuscular synaptic transmission (GO:0007274)3.18728110
81prepulse inhibition (GO:0060134)3.17672587
82regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.17153247
83regulation of synapse maturation (GO:0090128)3.16919113
84regulation of synaptic transmission, glutamatergic (GO:0051966)3.15593171
85negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.11661615
86regulation of synapse assembly (GO:0051963)3.11200122
87neuronal ion channel clustering (GO:0045161)3.09440154
88regulation of excitatory postsynaptic membrane potential (GO:0060079)3.06637759
89positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.06046404
90presynaptic membrane assembly (GO:0097105)3.05215875
91long-term synaptic potentiation (GO:0060291)3.05039391
92regulation of postsynaptic membrane potential (GO:0060078)3.04996259
93cerebellar granule cell differentiation (GO:0021707)3.02404454
94thyroid hormone metabolic process (GO:0042403)3.01239199
95positive regulation of granulocyte differentiation (GO:0030854)3.00073645
96glycine transport (GO:0015816)2.97544741
97interferon-gamma production (GO:0032609)2.97064080
98negative regulation of cAMP-mediated signaling (GO:0043951)2.97028968
99G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.96765771
100response to auditory stimulus (GO:0010996)2.95502355
101atrial cardiac muscle cell action potential (GO:0086014)2.95405520
102regulation of microtubule-based movement (GO:0060632)2.93512632
103regulation of neurotransmitter secretion (GO:0046928)2.93261852
104synaptic transmission (GO:0007268)2.92522309
105mast cell activation (GO:0045576)2.92398434
106learning (GO:0007612)2.90927875
107activation of protein kinase A activity (GO:0034199)2.90892200
108intraspecies interaction between organisms (GO:0051703)2.89999987
109social behavior (GO:0035176)2.89999987
110response to pheromone (GO:0019236)2.89072617
111auditory behavior (GO:0031223)2.88763150
112positive regulation of membrane potential (GO:0045838)2.87698810
113positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.87296426
114thyroid hormone generation (GO:0006590)2.87132471
115cellular potassium ion homeostasis (GO:0030007)2.85617811
116cell differentiation in hindbrain (GO:0021533)2.85466253
117membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.85429499
118synapse organization (GO:0050808)2.83807144
119regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.83588847
120sulfation (GO:0051923)2.83561039
121positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.82744101
122membrane hyperpolarization (GO:0060081)2.81907363
123establishment of protein localization to Golgi (GO:0072600)2.80840198
124regulation of synapse structural plasticity (GO:0051823)2.80540300
125water-soluble vitamin biosynthetic process (GO:0042364)2.80057228
126presynaptic membrane organization (GO:0097090)2.78656010
127regulation of synapse organization (GO:0050807)2.77813462
128regulation of neurotransmitter transport (GO:0051588)2.77757626
129regulation of synaptic plasticity (GO:0048167)2.77258404
130nonmotile primary cilium assembly (GO:0035058)2.74729366
131protein targeting to Golgi (GO:0000042)2.73732681
132retrograde transport, vesicle recycling within Golgi (GO:0000301)2.73347084
133behavioral defense response (GO:0002209)2.73320189
134behavioral fear response (GO:0001662)2.73320189
135establishment of nucleus localization (GO:0040023)2.71510100
136regulation of synaptic transmission (GO:0050804)2.71320709
137ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.71298345
138regulation of vesicle fusion (GO:0031338)2.71211778
139vesicle transport along microtubule (GO:0047496)2.70597104
140innervation (GO:0060384)2.70557554
141neurotransmitter biosynthetic process (GO:0042136)2.69976542
142neuromuscular process (GO:0050905)2.69145400
143positive regulation of CREB transcription factor activity (GO:0032793)2.68591710
144mating behavior (GO:0007617)2.68511814
145membrane depolarization (GO:0051899)2.68223692
146regulation of collateral sprouting (GO:0048670)2.64583615
147cellular response to nicotine (GO:0071316)2.62579937
148glycerophospholipid catabolic process (GO:0046475)2.61021021
149neural tube formation (GO:0001841)2.60152855
150regulation of Rac protein signal transduction (GO:0035020)2.56782282
151positive regulation of mRNA catabolic process (GO:0061014)2.54352872
152cAMP catabolic process (GO:0006198)2.53128054
153insulin secretion (GO:0030073)2.52883563
154negative regulation of cell killing (GO:0031342)2.52673386
155negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.52673386
156negative regulation of cytosolic calcium ion concentration (GO:0051481)2.51694983
157phosphorylated carbohydrate dephosphorylation (GO:0046838)2.51471583
158inositol phosphate dephosphorylation (GO:0046855)2.51471583
159inositol phosphate catabolic process (GO:0071545)2.51279208
160regulation of isotype switching to IgG isotypes (GO:0048302)2.51042525
161axoneme assembly (GO:0035082)2.46420595
162detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.45675501
163T cell selection (GO:0045058)2.45431893
164response to interleukin-15 (GO:0070672)2.44224570
165retinal cone cell development (GO:0046549)2.41906628
166regulation of gamma-delta T cell differentiation (GO:0045586)2.40798524
167embryonic hemopoiesis (GO:0035162)2.39916157
168epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.35182850
169protein localization to cilium (GO:0061512)2.34430539
170positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.34264240
171regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.34264240
172positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.32669476
173regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.32669476
174response to cocaine (GO:0042220)2.32184794
175regulation of clathrin-mediated endocytosis (GO:2000369)2.29900680
176regulation of gamma-delta T cell activation (GO:0046643)2.29154137
177termination of G-protein coupled receptor signaling pathway (GO:0038032)2.28994201
178alpha-beta T cell differentiation (GO:0046632)2.28519770
179thymic T cell selection (GO:0045061)2.27778074
180phosphatidylinositol dephosphorylation (GO:0046856)2.27680692
181response to amphetamine (GO:0001975)2.27563389
182positive thymic T cell selection (GO:0045059)2.27298431
183positive regulation of T cell differentiation in thymus (GO:0033089)2.27144325
184phospholipid dephosphorylation (GO:0046839)2.24676188
185photoreceptor cell development (GO:0042461)2.24443422
186membrane depolarization during action potential (GO:0086010)2.24067059
187regulation of neurotransmitter uptake (GO:0051580)2.22675220
188detection of mechanical stimulus involved in sensory perception (GO:0050974)2.22630372
189auditory receptor cell differentiation (GO:0042491)2.20304106
190eye photoreceptor cell development (GO:0042462)2.19236354
191protein localization to Golgi apparatus (GO:0034067)2.18714198
192cyclic nucleotide catabolic process (GO:0009214)2.17902281
193response to corticosterone (GO:0051412)2.17168093
194piRNA metabolic process (GO:0034587)2.16146825
195phenol-containing compound catabolic process (GO:0019336)2.15613204

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.87030485
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.74180044
3* GBX2_23144817_ChIP-Seq_PC3_Human3.52409577
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.51127856
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.08740710
6JARID2_20064375_ChIP-Seq_MESCs_Mouse3.06685143
7* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.06040206
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.03093106
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.76079381
10* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.68931587
11* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.68931587
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.68423704
13* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.64611943
14* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.63385958
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.60219741
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.60142170
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.60050557
18CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.55000209
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.48578790
20TAF15_26573619_Chip-Seq_HEK293_Human2.35035834
21REST_21632747_ChIP-Seq_MESCs_Mouse2.31155762
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.30799896
23* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.28441127
24* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.28333634
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.26495986
26FLI1_27457419_Chip-Seq_LIVER_Mouse2.25300713
27SUZ12_27294783_Chip-Seq_ESCs_Mouse2.23072586
28AR_21572438_ChIP-Seq_LNCaP_Human2.21164086
29EZH2_27294783_Chip-Seq_ESCs_Mouse2.13915077
30DROSHA_22980978_ChIP-Seq_HELA_Human2.10146190
31RUNX_20019798_ChIP-Seq_JUKART_Human2.09678363
32NOTCH1_21737748_ChIP-Seq_TLL_Human2.06332170
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.96812302
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.96178408
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.89677991
36* REST_18959480_ChIP-ChIP_MESCs_Mouse1.89029516
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.86602088
38SMAD_19615063_ChIP-ChIP_OVARY_Human1.86558690
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.82815469
40VDR_22108803_ChIP-Seq_LS180_Human1.78798671
41RARB_27405468_Chip-Seq_BRAIN_Mouse1.78785404
42IKZF1_21737484_ChIP-ChIP_HCT116_Human1.78461551
43* SMAD4_21799915_ChIP-Seq_A2780_Human1.78133968
44RNF2_27304074_Chip-Seq_NSC_Mouse1.76789940
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.73566183
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.67917397
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.66589154
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.66432483
49* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.65225520
50EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63063116
51CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.62044984
52PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60448999
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.57892228
54P300_19829295_ChIP-Seq_ESCs_Human1.54009543
55ER_23166858_ChIP-Seq_MCF-7_Human1.45956593
56RING1B_27294783_Chip-Seq_ESCs_Mouse1.45723081
57SALL1_21062744_ChIP-ChIP_HESCs_Human1.39180549
58ERG_21242973_ChIP-ChIP_JURKAT_Human1.38993075
59EWS_26573619_Chip-Seq_HEK293_Human1.38277603
60* SOX2_21211035_ChIP-Seq_LN229_Gbm1.35461115
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.34889683
62FUS_26573619_Chip-Seq_HEK293_Human1.34385610
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34137965
64PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33071003
65RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31832005
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.31687885
67FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.29315274
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29151468
69* FLI1_21867929_ChIP-Seq_TH2_Mouse1.27496163
70CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26891758
71AHR_22903824_ChIP-Seq_MCF-7_Human1.26528015
72TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26422069
73AR_25329375_ChIP-Seq_VCAP_Human1.26049521
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23748269
75ARNT_22903824_ChIP-Seq_MCF-7_Human1.22620288
76ZNF217_24962896_ChIP-Seq_MCF-7_Human1.21522616
77RING1B_27294783_Chip-Seq_NPCs_Mouse1.21469899
78AR_19668381_ChIP-Seq_PC3_Human1.20420525
79ZNF274_21170338_ChIP-Seq_K562_Hela1.20409496
80* STAT3_23295773_ChIP-Seq_U87_Human1.18264695
81CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.18082571
82TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17961053
83TP53_20018659_ChIP-ChIP_R1E_Mouse1.14875975
84RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.14172621
85TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11584503
86* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11380670
87TCF4_22108803_ChIP-Seq_LS180_Human1.10977479
88OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10797681
89NANOG_18555785_Chip-Seq_ESCs_Mouse1.10135810
90SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09596046
91IGF1R_20145208_ChIP-Seq_DFB_Human1.09347449
92VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.09067224
93POU3F2_20337985_ChIP-ChIP_501MEL_Human1.08936045
94ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.08767101
95* CBP_20019798_ChIP-Seq_JUKART_Human1.08305772
96* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08305772
97STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.08222728
98* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07321214
99* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.07299883
100* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.06636924
101AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06487089
102LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.05808505
103MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.05785673
104NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05779893
105DNAJC2_21179169_ChIP-ChIP_NT2_Human1.05765035
106TP53_16413492_ChIP-PET_HCT116_Human1.05580714
107* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.04974789
108PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04534410
109SCL_19346495_ChIP-Seq_HPC-7_Human1.04533430
110TP53_18474530_ChIP-ChIP_U2OS_Human1.04424638
111TCF4_23295773_ChIP-Seq_U87_Human1.04253380
112STAT6_21828071_ChIP-Seq_BEAS2B_Human1.03558717
113WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.02704614
114GATA3_26560356_Chip-Seq_TH2_Human1.02412205
115WDR5_24793694_ChIP-Seq_LNCAP_Human1.02202016
116RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.01476711
117GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00881182
118RUNX2_22187159_ChIP-Seq_PCA_Human1.00706837
119POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00627848
120TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00627848
121MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98702564
122EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97858026
123SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.97374454
124POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97351224
125TCF4_18268006_ChIP-ChIP_LS174T_Human0.97305149
126TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97177454
127FOXA1_25329375_ChIP-Seq_VCAP_Human0.97019630
128FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97019630
129KDM2B_26808549_Chip-Seq_REH_Human0.96929281
130GATA3_27048872_Chip-Seq_THYMUS_Human0.96922502
131P53_22387025_ChIP-Seq_ESCs_Mouse0.96688619
132UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96470903
133P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96170609
134* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95489906
135SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95204416
136GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94305343
137BCAT_22108803_ChIP-Seq_LS180_Human0.94269212
138* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93934229
139EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93805417
140RXR_22108803_ChIP-Seq_LS180_Human0.93449091
141* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92843823
142TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91765303
143GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91399332
144* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.91383012
145SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90956030
146* SMAD3_21741376_ChIP-Seq_ESCs_Human0.90582703
147FOXA1_21572438_ChIP-Seq_LNCaP_Human0.89955999
148E2F1_18555785_Chip-Seq_ESCs_Mouse0.88756114
149PRDM14_20953172_ChIP-Seq_ESCs_Human0.88577972

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.65342474
2MP0003880_abnormal_central_pattern3.88305409
3MP0003635_abnormal_synaptic_transmissio3.50657114
4MP0009046_muscle_twitch3.49620381
5MP0009745_abnormal_behavioral_response3.03735940
6MP0002064_seizures2.87190940
7MP0003122_maternal_imprinting2.85151386
8MP0002063_abnormal_learning/memory/cond2.67800975
9MP0001501_abnormal_sleep_pattern2.65801470
10MP0005423_abnormal_somatic_nervous2.52556819
11MP0002572_abnormal_emotion/affect_behav2.48550595
12MP0001968_abnormal_touch/_nociception2.45065078
13MP0003763_abnormal_thymus_physiology2.42814922
14MP0002735_abnormal_chemical_nociception2.35396650
15MP0006276_abnormal_autonomic_nervous2.34859682
16MP0000383_abnormal_hair_follicle2.28360547
17MP0002184_abnormal_innervation2.26299187
18MP0002272_abnormal_nervous_system2.23881172
19MP0003787_abnormal_imprinting2.23759799
20MP0001486_abnormal_startle_reflex2.14413428
21MP0005394_taste/olfaction_phenotype2.08765279
22MP0005499_abnormal_olfactory_system2.08765279
23MP0002734_abnormal_mechanical_nocicepti2.07444966
24MP0010678_abnormal_skin_adnexa1.99464884
25MP0005646_abnormal_pituitary_gland1.98191542
26MP0002736_abnormal_nociception_after1.90335258
27MP0000579_abnormal_nail_morphology1.89962331
28MP0004270_analgesia1.87715673
29MP0008789_abnormal_olfactory_epithelium1.87675220
30MP0002067_abnormal_sensory_capabilities1.84979225
31MP0002557_abnormal_social/conspecific_i1.82800886
32MP0001188_hyperpigmentation1.81469503
33MP0002138_abnormal_hepatobiliary_system1.79823542
34MP0001984_abnormal_olfaction1.78439313
35MP0005645_abnormal_hypothalamus_physiol1.76271168
36MP0003123_paternal_imprinting1.73511368
37MP0002822_catalepsy1.68801834
38MP0002733_abnormal_thermal_nociception1.68688087
39MP0002254_reproductive_system_inflammat1.65154276
40MP0000778_abnormal_nervous_system1.64960998
41MP0003121_genomic_imprinting1.62899412
42MP0008569_lethality_at_weaning1.59090546
43MP0001970_abnormal_pain_threshold1.58880029
44MP0004381_abnormal_hair_follicle1.56991438
45MP0000955_abnormal_spinal_cord1.55101336
46MP0001440_abnormal_grooming_behavior1.52254927
47MP0009780_abnormal_chondrocyte_physiolo1.52018388
48MP0005174_abnormal_tail_pigmentation1.50226062
49MP0005310_abnormal_salivary_gland1.47120901
50MP0002638_abnormal_pupillary_reflex1.47042003
51MP0001529_abnormal_vocalization1.46905047
52MP0004043_abnormal_pH_regulation1.42278857
53MP0000427_abnormal_hair_cycle1.41197763
54MP0003724_increased_susceptibility_to1.40970156
55MP0004811_abnormal_neuron_physiology1.40101977
56MP0005386_behavior/neurological_phenoty1.39841301
57MP0004924_abnormal_behavior1.39841301
58MP0001851_eye_inflammation1.36929720
59MP0004142_abnormal_muscle_tone1.35507049
60MP0003195_calcinosis1.33993906
61MP0000537_abnormal_urethra_morphology1.33684501
62MP0008057_abnormal_DNA_replication1.32983586
63MP0004858_abnormal_nervous_system1.30079978
64MP0002882_abnormal_neuron_morphology1.29112436
65MP0005367_renal/urinary_system_phenotyp1.23743801
66MP0000516_abnormal_urinary_system1.23743801
67MP0002928_abnormal_bile_duct1.22076380
68MP0002066_abnormal_motor_capabilities/c1.20239445
69MP0003283_abnormal_digestive_organ1.19282854
70MP0000566_synostosis1.18116543
71MP0005075_abnormal_melanosome_morpholog1.17837441
72MP0001502_abnormal_circadian_rhythm1.15593803
73MP0005409_darkened_coat_color1.13305357
74MP0002796_impaired_skin_barrier1.13010159
75MP0000534_abnormal_ureter_morphology1.12992938
76MP0000465_gastrointestinal_hemorrhage1.11961960
77MP0000569_abnormal_digit_pigmentation1.11790033
78MP0003941_abnormal_skin_development1.10655272
79MP0005551_abnormal_eye_electrophysiolog1.10068838
80MP0002693_abnormal_pancreas_physiology1.07515240
81MP0002152_abnormal_brain_morphology1.02712557
82MP0003938_abnormal_ear_development1.02604833
83MP0000703_abnormal_thymus_morphology1.01764885
84MP0005464_abnormal_platelet_physiology1.01118262
85MP0001765_abnormal_ion_homeostasis1.00089376
86MP0000015_abnormal_ear_pigmentation0.98259006
87MP0005623_abnormal_meninges_morphology0.96146128
88MP0002909_abnormal_adrenal_gland0.95805907
89MP0002234_abnormal_pharynx_morphology0.95563101
90MP0001177_atelectasis0.95485875
91MP0003942_abnormal_urinary_system0.94095808
92MP0002751_abnormal_autonomic_nervous0.92877637
93MP0001944_abnormal_pancreas_morphology0.92637223
94MP0008995_early_reproductive_senescence0.92069328
95MP0003879_abnormal_hair_cell0.91786600
96MP0004885_abnormal_endolymph0.91680208
97MP0001299_abnormal_eye_distance/0.90456822
98MP0000631_abnormal_neuroendocrine_gland0.89587943
99MP0004742_abnormal_vestibular_system0.88369663
100MP0000467_abnormal_esophagus_morphology0.87987993
101MP0002233_abnormal_nose_morphology0.86679318
102MP0005671_abnormal_response_to0.86527712
103MP0000049_abnormal_middle_ear0.85011159
104MP0002139_abnormal_hepatobiliary_system0.84254601
105MP0006072_abnormal_retinal_apoptosis0.84095331
106MP0002752_abnormal_somatic_nervous0.83850876
107MP0001346_abnormal_lacrimal_gland0.83496745
108MP0001905_abnormal_dopamine_level0.83309822
109MP0001986_abnormal_taste_sensitivity0.83231091
110MP0001485_abnormal_pinna_reflex0.82767602
111MP0003329_amyloid_beta_deposits0.82675967
112MP0008961_abnormal_basal_metabolism0.82528665
113MP0004233_abnormal_muscle_weight0.80173473
114MP0003385_abnormal_body_wall0.79561588
115MP0003861_abnormal_nervous_system0.79525597
116MP0002095_abnormal_skin_pigmentation0.79232760
117MP0000026_abnormal_inner_ear0.79230130
118MP0001800_abnormal_humoral_immune0.78799364
119MP0002277_abnormal_respiratory_mucosa0.78479935
120MP0008872_abnormal_physiological_respon0.78196059
121MP0003633_abnormal_nervous_system0.78049232
122MP0003436_decreased_susceptibility_to0.78002414
123MP0002163_abnormal_gland_morphology0.77676139
124MP0001963_abnormal_hearing_physiology0.77580864
125MP0002653_abnormal_ependyma_morphology0.77528501
126MP0005377_hearing/vestibular/ear_phenot0.77481942
127MP0003878_abnormal_ear_physiology0.77481942
128MP0003755_abnormal_palate_morphology0.77232413
129MP0005084_abnormal_gallbladder_morpholo0.76651661
130MP0001270_distended_abdomen0.76584131
131MP0004130_abnormal_muscle_cell0.75953890
132MP0001943_abnormal_respiration0.75117275
133MP0002876_abnormal_thyroid_physiology0.74653351
134MP0005448_abnormal_energy_balance0.74082465
135MP0005379_endocrine/exocrine_gland_phen0.73880964
136MP0002069_abnormal_eating/drinking_beha0.73110477
137MP0004808_abnormal_hematopoietic_stem0.73038552
138MP0009250_abnormal_appendicular_skeleto0.72784091
139MP0008877_abnormal_DNA_methylation0.72660700
140MP0004133_heterotaxia0.70885366
141MP0002723_abnormal_immune_serum0.70289455
142MP0010386_abnormal_urinary_bladder0.70236652
143MP0005535_abnormal_body_temperature0.69634724
144MP0009278_abnormal_bone_marrow0.69117827
145MP0002398_abnormal_bone_marrow0.68864931
146MP0002249_abnormal_larynx_morphology0.68803548
147MP0009053_abnormal_anal_canal0.67053957
148MP0010770_preweaning_lethality0.66415175
149MP0002082_postnatal_lethality0.66415175
150MP0002102_abnormal_ear_morphology0.66360269

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.13833912
2Atonic seizures (HP:0010819)5.75972857
3Febrile seizures (HP:0002373)5.53127791
4Focal seizures (HP:0007359)5.03070114
5Epileptic encephalopathy (HP:0200134)4.27695291
6Absence seizures (HP:0002121)4.25327838
7Stomatitis (HP:0010280)4.17150102
8Visual hallucinations (HP:0002367)4.05160795
9Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.88588795
10Dialeptic seizures (HP:0011146)3.78957767
11Progressive cerebellar ataxia (HP:0002073)3.74536439
12Myokymia (HP:0002411)3.41915173
13Generalized tonic-clonic seizures (HP:0002069)3.24701965
14Progressive inability to walk (HP:0002505)3.21240431
15Limb dystonia (HP:0002451)3.02837037
16Abnormal hair whorl (HP:0010721)2.96570387
17Pustule (HP:0200039)2.96478818
18Abnormality of the labia minora (HP:0012880)2.94046933
19Molar tooth sign on MRI (HP:0002419)2.92505695
20Abnormality of midbrain morphology (HP:0002418)2.92505695
21Type II lissencephaly (HP:0007260)2.82369697
22Congenital stationary night blindness (HP:0007642)2.74182024
23Pancreatic fibrosis (HP:0100732)2.73979293
24Decreased central vision (HP:0007663)2.71618180
25Hyperventilation (HP:0002883)2.69346420
26Pancreatic cysts (HP:0001737)2.69317358
27Gait imbalance (HP:0002141)2.66887003
28Intestinal atresia (HP:0011100)2.64897853
29Broad-based gait (HP:0002136)2.59982363
30True hermaphroditism (HP:0010459)2.54679597
31Nephronophthisis (HP:0000090)2.53174799
32Failure to thrive in infancy (HP:0001531)2.52068957
33Narrow nasal bridge (HP:0000446)2.50660277
34Palmoplantar hyperkeratosis (HP:0000972)2.50125492
35Polydipsia (HP:0001959)2.47693262
36Abnormal drinking behavior (HP:0030082)2.47693262
37Dyskinesia (HP:0100660)2.43660540
38Abnormal eating behavior (HP:0100738)2.39581023
39Thyroid-stimulating hormone excess (HP:0002925)2.38772783
40Congenital primary aphakia (HP:0007707)2.38316110
41Pheochromocytoma (HP:0002666)2.38281927
42Gaze-evoked nystagmus (HP:0000640)2.37576028
43Polyphagia (HP:0002591)2.36995005
44Plantar hyperkeratosis (HP:0007556)2.36835665
45Chronic hepatic failure (HP:0100626)2.34990551
46Palmar hyperkeratosis (HP:0010765)2.34796441
47Prolonged bleeding time (HP:0003010)2.33041751
48Specific learning disability (HP:0001328)2.30724792
49Abnormality of the renal medulla (HP:0100957)2.30615781
50Abnormality of the columella (HP:0009929)2.30097234
51Elevated erythrocyte sedimentation rate (HP:0003565)2.28509924
52Episodic fever (HP:0001954)2.28482029
53Fetal akinesia sequence (HP:0001989)2.26650795
54Genital tract atresia (HP:0001827)2.26288977
55Impaired social interactions (HP:0000735)2.25102354
56Abnormal social behavior (HP:0012433)2.25102354
57Vaginal atresia (HP:0000148)2.24542544
58Truncal ataxia (HP:0002078)2.24235948
59Hemiplegia (HP:0002301)2.20905833
60Parakeratosis (HP:0001036)2.20805771
61Hypoventilation (HP:0002791)2.20692939
62Nephrogenic diabetes insipidus (HP:0009806)2.19551070
63Genetic anticipation (HP:0003743)2.18077111
64Aqueductal stenosis (HP:0002410)2.18068065
65Abnormal rod and cone electroretinograms (HP:0008323)2.16657030
66Abnormality of nail color (HP:0100643)2.16460433
67Poor suck (HP:0002033)2.15972087
68Attenuation of retinal blood vessels (HP:0007843)2.14326553
69Furrowed tongue (HP:0000221)2.13714783
70Drooling (HP:0002307)2.13579758
71Excessive salivation (HP:0003781)2.13579758
72Absent speech (HP:0001344)2.12986720
73Widely spaced teeth (HP:0000687)2.10132432
74Abnormality of the renal cortex (HP:0011035)2.10046871
75Dysdiadochokinesis (HP:0002075)2.09762171
76Protruding tongue (HP:0010808)2.07804421
77Impaired vibration sensation in the lower limbs (HP:0002166)2.07494233
78Polyuria (HP:0000103)2.07336064
79Retrobulbar optic neuritis (HP:0100654)2.06609840
80Optic neuritis (HP:0100653)2.06609840
81Medial flaring of the eyebrow (HP:0010747)2.05903735
82Poor eye contact (HP:0000817)2.05081844
83Morphological abnormality of the middle ear (HP:0008609)2.04799658
84Stomach cancer (HP:0012126)2.03661741
85Abnormality of the nasal septum (HP:0000419)2.01452186
86Diplopia (HP:0000651)2.01393914
87Abnormality of binocular vision (HP:0011514)2.01393914
88Neuroendocrine neoplasm (HP:0100634)2.00838199
89Hypothermia (HP:0002045)2.00356262
90Aplasia cutis congenita (HP:0001057)1.99370995
91Papilledema (HP:0001085)1.98639715
92Generalized hypotonia (HP:0001290)1.98179397
93Large for gestational age (HP:0001520)1.95655318
94Labial hypoplasia (HP:0000066)1.95624360
95Lip pit (HP:0100267)1.95103437
96Action tremor (HP:0002345)1.94549483
97Split foot (HP:0001839)1.93420606
98Ankle clonus (HP:0011448)1.92832788
99Depression (HP:0000716)1.92627697
100Amblyopia (HP:0000646)1.92390086
101Abnormality of the lacrimal duct (HP:0011481)1.92216967
102Sleep apnea (HP:0010535)1.90776457
103Hyperthyroidism (HP:0000836)1.90712875
104Anophthalmia (HP:0000528)1.90596384
105Orchitis (HP:0100796)1.89457217
106Impaired smooth pursuit (HP:0007772)1.89341188
107Myositis (HP:0100614)1.88398501
108Milia (HP:0001056)1.87838587
109Status epilepticus (HP:0002133)1.87412363
110Fair hair (HP:0002286)1.85235339
111Hip dysplasia (HP:0001385)1.84802185
112Epileptiform EEG discharges (HP:0011182)1.83140096
113Neoplasm of the peripheral nervous system (HP:0100007)1.82557628
114Nasolacrimal duct obstruction (HP:0000579)1.81807360
115EEG with generalized epileptiform discharges (HP:0011198)1.81475166
116Volvulus (HP:0002580)1.81310347
117Thick nail (HP:0001805)1.81053134
118Supranuclear gaze palsy (HP:0000605)1.80922978
119Lissencephaly (HP:0001339)1.80922898
120Abnormality of the nasolacrimal system (HP:0000614)1.80775458
121Agitation (HP:0000713)1.80497003
122Abnormality of macular pigmentation (HP:0008002)1.80139710
123Mixed hearing impairment (HP:0000410)1.80099102
124Oral leukoplakia (HP:0002745)1.79653721
125Inability to walk (HP:0002540)1.78750460
126Poor coordination (HP:0002370)1.78441458
127Esotropia (HP:0000565)1.78245619
128Severe visual impairment (HP:0001141)1.77638817
129Bradykinesia (HP:0002067)1.76754144
130Exotropia (HP:0000577)1.76743151
131Ventricular fibrillation (HP:0001663)1.75763810
132Alacrima (HP:0000522)1.75347083
133Increased CSF protein (HP:0002922)1.73869046
134Tubular atrophy (HP:0000092)1.73095218
135Hypsarrhythmia (HP:0002521)1.72364908
136Open mouth (HP:0000194)1.72274683
137Increased IgE level (HP:0003212)1.72076605
138T lymphocytopenia (HP:0005403)1.71985551
139Anxiety (HP:0000739)1.71441598
140Hypoplastic female external genitalia (HP:0012815)1.71228300
141Scanning speech (HP:0002168)1.71014117
142Alopecia of scalp (HP:0002293)1.70961297
143Alveolar cell carcinoma (HP:0006519)1.70406532
144Mutism (HP:0002300)1.69904139
145Postural instability (HP:0002172)1.69525368
146Macular degeneration (HP:0000608)1.68931493
147Neoplasm of the tracheobronchial system (HP:0100552)1.68324447
148Abnormality of ocular smooth pursuit (HP:0000617)1.67953611
149Absent rod-and cone-mediated responses on ERG (HP:0007688)1.67620867
150Pointed chin (HP:0000307)1.67339689
151Urinary urgency (HP:0000012)1.67210700
152Cystic liver disease (HP:0006706)1.67160968
153Abnormality of T cell number (HP:0011839)1.65173294
154Sex reversal (HP:0012245)1.64663033
155Abnormal sex determination (HP:0012244)1.64663033
156Pili torti (HP:0003777)1.63885952
157Hemiparesis (HP:0001269)1.63826967
158Congenital sensorineural hearing impairment (HP:0008527)1.63471652
159Truncal obesity (HP:0001956)1.62588901
160Urinary bladder sphincter dysfunction (HP:0002839)1.61140494
161Gastrointestinal atresia (HP:0002589)1.61010664
162Goiter (HP:0000853)1.60920188
163Bilateral microphthalmos (HP:0007633)1.59123735
164Eczematoid dermatitis (HP:0000976)1.58735829
165Dysmetria (HP:0001310)1.58051841
166Hypercortisolism (HP:0001578)1.58041728
167Horizontal nystagmus (HP:0000666)1.56853199
168Amyotrophic lateral sclerosis (HP:0007354)1.55587562
169Hypodontia (HP:0000668)1.54624776

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.61363420
2CASK4.42813842
3MAP3K43.58567208
4FRK3.52237189
5MARK13.20936519
6MAP3K93.19095698
7NTRK23.12919551
8MAP2K73.09578216
9PINK12.92055916
10NLK2.89504139
11MAP3K122.88309233
12TXK2.49893212
13MINK12.48615239
14TSSK62.18153800
15ZAK2.15845733
16MAP2K42.04682823
17PNCK2.04398416
18IRAK11.98473589
19CAMKK21.94809070
20PLK21.78980953
21BMPR1B1.65093792
22PAK61.60674538
23EPHA31.53170713
24TAOK31.52886659
25MAP4K11.48301071
26LATS21.47814654
27KSR11.45040306
28MAPK131.41589604
29PRKCG1.35249877
30STK381.35226977
31UHMK11.33109673
32ERBB41.32083975
33ITK1.31124962
34PRPF4B1.29313464
35CDK51.26882445
36EPHB21.20919757
37TNK21.20016482
38MAPKAPK51.19101259
39NTRK11.18269992
40PTK2B1.17308723
41INSRR1.16682388
42GRK51.16141938
43ERBB31.16069256
44TYRO31.13685111
45NEK61.12494996
46TLK11.12264094
47GRK61.11415987
48CSNK1G11.09886338
49WNK41.06846021
50IRAK21.04889676
51CAMK2A1.04687789
52FGFR31.04362268
53RPS6KA51.03726328
54GRK10.98601158
55AKT30.97789053
56ALK0.97359754
57DAPK10.95943452
58BRD40.95397119
59SIK20.94601035
60WNK30.93573790
61EPHB10.91698119
62EPHA40.91336689
63CDK190.90892982
64PRKCH0.90136057
65PASK0.89763407
66SIK30.89009235
67SGK20.88564824
68FER0.88551306
69CAMKK10.88474405
70NUAK10.87721016
71PRKD30.86556550
72CDC42BPA0.86081399
73PRKCE0.85339007
74PRKCQ0.85229121
75DYRK1A0.84907036
76CDK180.82961416
77IKBKB0.81568046
78CSNK1G20.78713001
79NME10.78448822
80CHUK0.76734142
81CDK150.76666346
82MAP4K20.76193918
83RET0.76095489
84PAK30.73530020
85TNIK0.73524347
86PHKG20.72569253
87PHKG10.72569253
88ROCK20.72260221
89MKNK20.72115696
90TRPM70.72068325
91STK240.71838788
92MARK30.71801296
93HIPK20.71487023
94BUB10.70502605
95WNK10.69371025
96FGFR20.67850430
97MST40.66838308
98ZAP700.66141887
99CDK11A0.65427642
100MAP3K10.65052041
101CDK140.64793089
102CDK80.64505305
103STK110.64026123
104BTK0.63669380
105SGK10.63593496
106TEC0.63462849
107DDR20.63290759
108JAK30.62929073
109SGK2230.62349259
110SGK4940.62349259
111LCK0.61988048
112MAP3K20.60854012
113CAMK2B0.59277996
114STK390.58999497
115OXSR10.58526586
116ADRBK20.57318773
117SGK30.57243723
118ADRBK10.56217820
119PDGFRA0.55548292
120PLK30.54927582
121HCK0.54149739
122DYRK20.53727746
123CAMK2G0.52861033
124SYK0.52329831
125MAPK100.51865883
126DAPK20.51767155
127CDK30.51592685
128FGFR10.50755496
129ROCK10.50603046
130IKBKE0.50549716
131YES10.49529801
132CCNB10.49233531
133ACVR1B0.48660157
134BCR0.48651545
135RPS6KA30.47089606
136BRSK10.46969893
137CSNK1D0.46726650
138NEK10.45415201
139CSNK1G30.44855368
140CAMK10.44665650
141MARK20.44652043
142TAF10.44577791
143FES0.44470784
144GRK70.42391888
145PRKCB0.42377489
146CDK120.42270881
147MAP3K130.42266811
148PRKCZ0.42010277
149CAMK1D0.38780619
150CAMK1G0.37840250
151RPS6KA20.36934262
152FYN0.36827357
153CSNK1E0.36327249
154CAMK40.36010663
155MAPK90.34158120
156RPS6KB10.33984305

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.35580021
2Synaptic vesicle cycle_Homo sapiens_hsa047213.58680539
3GABAergic synapse_Homo sapiens_hsa047272.93071472
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.61767106
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.42915645
6Morphine addiction_Homo sapiens_hsa050322.41974161
7Olfactory transduction_Homo sapiens_hsa047402.28094025
8Circadian entrainment_Homo sapiens_hsa047132.14411637
9Long-term potentiation_Homo sapiens_hsa047202.04419734
10Amphetamine addiction_Homo sapiens_hsa050312.04169226
11Collecting duct acid secretion_Homo sapiens_hsa049662.03939702
12Glutamatergic synapse_Homo sapiens_hsa047241.99918379
13Taste transduction_Homo sapiens_hsa047421.98282526
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.88830685
15Dopaminergic synapse_Homo sapiens_hsa047281.87054259
16Serotonergic synapse_Homo sapiens_hsa047261.80399084
17Cocaine addiction_Homo sapiens_hsa050301.72243878
18Salivary secretion_Homo sapiens_hsa049701.65444007
19Linoleic acid metabolism_Homo sapiens_hsa005911.62443620
20Insulin secretion_Homo sapiens_hsa049111.56500773
21Cholinergic synapse_Homo sapiens_hsa047251.52478882
22Long-term depression_Homo sapiens_hsa047301.51956950
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.51110066
24Ether lipid metabolism_Homo sapiens_hsa005651.48903098
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.48021862
26Axon guidance_Homo sapiens_hsa043601.46532964
27Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.46373875
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.41284355
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.40937334
30Platelet activation_Homo sapiens_hsa046111.38997158
31Gastric acid secretion_Homo sapiens_hsa049711.38751055
32Calcium signaling pathway_Homo sapiens_hsa040201.32842920
33Type I diabetes mellitus_Homo sapiens_hsa049401.32386892
34Nitrogen metabolism_Homo sapiens_hsa009101.31490954
35Vibrio cholerae infection_Homo sapiens_hsa051101.30503362
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.28220946
37Oxytocin signaling pathway_Homo sapiens_hsa049211.27767340
38Selenocompound metabolism_Homo sapiens_hsa004501.25862334
39Aldosterone synthesis and secretion_Homo sapiens_hsa049251.25151466
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22556163
41GnRH signaling pathway_Homo sapiens_hsa049121.19848390
42Gap junction_Homo sapiens_hsa045401.19132886
43Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.16891978
44Renin secretion_Homo sapiens_hsa049241.15752618
45Estrogen signaling pathway_Homo sapiens_hsa049151.15363725
46ErbB signaling pathway_Homo sapiens_hsa040121.13218678
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.13092585
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08171753
49NOD-like receptor signaling pathway_Homo sapiens_hsa046211.06561496
50Type II diabetes mellitus_Homo sapiens_hsa049301.03540700
51Melanogenesis_Homo sapiens_hsa049161.03191845
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.03073596
53Regulation of autophagy_Homo sapiens_hsa041401.00045256
54Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.99389163
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.98817778
56Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97877704
57Maturity onset diabetes of the young_Homo sapiens_hsa049500.97522131
58Chemokine signaling pathway_Homo sapiens_hsa040620.94950646
59cAMP signaling pathway_Homo sapiens_hsa040240.94564348
60Primary immunodeficiency_Homo sapiens_hsa053400.92336138
61Cardiac muscle contraction_Homo sapiens_hsa042600.90279297
62Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.88718227
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.88378267
64MAPK signaling pathway_Homo sapiens_hsa040100.87663442
65Glioma_Homo sapiens_hsa052140.87167176
66Oocyte meiosis_Homo sapiens_hsa041140.86613213
67Dilated cardiomyopathy_Homo sapiens_hsa054140.86163767
68Acute myeloid leukemia_Homo sapiens_hsa052210.85518633
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85361141
70FoxO signaling pathway_Homo sapiens_hsa040680.85301702
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.85247278
72VEGF signaling pathway_Homo sapiens_hsa043700.85140910
73Hedgehog signaling pathway_Homo sapiens_hsa043400.84648529
74Glycerophospholipid metabolism_Homo sapiens_hsa005640.84230620
75Dorso-ventral axis formation_Homo sapiens_hsa043200.83697695
76Arachidonic acid metabolism_Homo sapiens_hsa005900.83472588
77Measles_Homo sapiens_hsa051620.82056281
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.80644675
79Sphingolipid metabolism_Homo sapiens_hsa006000.76900807
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.76696959
81Basal transcription factors_Homo sapiens_hsa030220.76157863
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74494924
83Basal cell carcinoma_Homo sapiens_hsa052170.74062265
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.73619427
85Phototransduction_Homo sapiens_hsa047440.72773456
86Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.71601973
87Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71503078
88Oxidative phosphorylation_Homo sapiens_hsa001900.70132019
89Wnt signaling pathway_Homo sapiens_hsa043100.70023174
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67971942
91Endometrial cancer_Homo sapiens_hsa052130.67057026
92Hippo signaling pathway_Homo sapiens_hsa043900.66457737
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.65594165
94Non-small cell lung cancer_Homo sapiens_hsa052230.64647454
95Colorectal cancer_Homo sapiens_hsa052100.64116133
96Vitamin B6 metabolism_Homo sapiens_hsa007500.61290789
97Osteoclast differentiation_Homo sapiens_hsa043800.60987550
98NF-kappa B signaling pathway_Homo sapiens_hsa040640.60645233
99Alcoholism_Homo sapiens_hsa050340.59290433
100Choline metabolism in cancer_Homo sapiens_hsa052310.59202650
101Parkinsons disease_Homo sapiens_hsa050120.58808407
102Ovarian steroidogenesis_Homo sapiens_hsa049130.58655237
103Rap1 signaling pathway_Homo sapiens_hsa040150.58622744
104Ras signaling pathway_Homo sapiens_hsa040140.58597770
105Melanoma_Homo sapiens_hsa052180.58567066
106Rheumatoid arthritis_Homo sapiens_hsa053230.58125818
107Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.57273728
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56941088
109Vascular smooth muscle contraction_Homo sapiens_hsa042700.54033119
110Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53207877
111mTOR signaling pathway_Homo sapiens_hsa041500.52606964
112Hematopoietic cell lineage_Homo sapiens_hsa046400.52492131
113TNF signaling pathway_Homo sapiens_hsa046680.52395915
114Phospholipase D signaling pathway_Homo sapiens_hsa040720.51739066
115Alzheimers disease_Homo sapiens_hsa050100.51366902
116Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.50684626
117Inositol phosphate metabolism_Homo sapiens_hsa005620.49402969
118ABC transporters_Homo sapiens_hsa020100.48859924
119B cell receptor signaling pathway_Homo sapiens_hsa046620.47361356
120T cell receptor signaling pathway_Homo sapiens_hsa046600.47019911
121Thyroid hormone synthesis_Homo sapiens_hsa049180.46958631
122Glycerolipid metabolism_Homo sapiens_hsa005610.46476347
123Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45265655
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44363405
125Prolactin signaling pathway_Homo sapiens_hsa049170.43501139
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42450909
127Insulin signaling pathway_Homo sapiens_hsa049100.40011219
128Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39353743
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38938141
130Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.37707532
131Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36520517
132Phagosome_Homo sapiens_hsa041450.36513942
133Prion diseases_Homo sapiens_hsa050200.34433005
134Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.34411033
135Huntingtons disease_Homo sapiens_hsa050160.34401000
136Renal cell carcinoma_Homo sapiens_hsa052110.34117378
137Circadian rhythm_Homo sapiens_hsa047100.32772482
138Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32733102
139Endocytosis_Homo sapiens_hsa041440.32676334
140Proteoglycans in cancer_Homo sapiens_hsa052050.32559693
141Glucagon signaling pathway_Homo sapiens_hsa049220.32293000

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