BTBD18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)6.83872795
2vitamin transmembrane transport (GO:0035461)6.08423269
3purine nucleobase biosynthetic process (GO:0009113)5.84818528
4regulation of attachment of spindle microtubules to kinetochore (GO:0051988)5.82551053
5regulation of spindle organization (GO:0090224)5.68046473
6DNA replication checkpoint (GO:0000076)5.41919846
7metaphase plate congression (GO:0051310)5.29797936
8monoubiquitinated protein deubiquitination (GO:0035520)5.12384223
9regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)5.09596711
10nucleobase biosynthetic process (GO:0046112)5.07112194
11ribosome assembly (GO:0042255)4.93709241
12pericardium development (GO:0060039)4.92130641
13ribosome biogenesis (GO:0042254)4.77911104
14protein localization to kinetochore (GO:0034501)4.51170752
15regulation of mitotic spindle organization (GO:0060236)4.42556555
16positive regulation of chromosome segregation (GO:0051984)4.39604180
17regulation of RNA export from nucleus (GO:0046831)4.36657148
18microtubule depolymerization (GO:0007019)4.32471245
19protein localization to chromosome, centromeric region (GO:0071459)4.31604756
20inner cell mass cell proliferation (GO:0001833)4.30860677
21folic acid metabolic process (GO:0046655)4.22833216
22meiosis I (GO:0007127)4.13820604
23termination of RNA polymerase III transcription (GO:0006386)4.11715105
24transcription elongation from RNA polymerase III promoter (GO:0006385)4.11715105
25male meiosis I (GO:0007141)4.04593990
26cellular response to ATP (GO:0071318)4.04393944
27establishment of chromosome localization (GO:0051303)4.03454244
28mitotic chromosome condensation (GO:0007076)3.98617779
29regulation of hippo signaling (GO:0035330)3.96862346
30preassembly of GPI anchor in ER membrane (GO:0016254)3.93287487
31protein K6-linked ubiquitination (GO:0085020)3.93097767
32synaptonemal complex assembly (GO:0007130)3.93054544
33termination of RNA polymerase I transcription (GO:0006363)3.91660587
34transcription elongation from RNA polymerase I promoter (GO:0006362)3.89629482
35nuclear pore organization (GO:0006999)3.88474493
36spindle checkpoint (GO:0031577)3.87029441
37regulation of chromosome segregation (GO:0051983)3.86999983
38endocardial cushion development (GO:0003197)3.82382962
39regulation of exit from mitosis (GO:0007096)3.81251407
40detection of light stimulus involved in sensory perception (GO:0050962)3.81143142
41detection of light stimulus involved in visual perception (GO:0050908)3.81143142
42rRNA modification (GO:0000154)3.79015454
43sister chromatid cohesion (GO:0007062)3.78946317
44mitotic sister chromatid segregation (GO:0000070)3.74674032
45regulation of meiosis I (GO:0060631)3.74585205
46mitotic sister chromatid cohesion (GO:0007064)3.73052134
47ovulation from ovarian follicle (GO:0001542)3.71402386
48protein localization to chromosome (GO:0034502)3.71197915
49transcription from RNA polymerase I promoter (GO:0006360)3.70025623
50piRNA metabolic process (GO:0034587)3.67310192
51mitotic nuclear envelope disassembly (GO:0007077)3.66761127
52nuclear pore complex assembly (GO:0051292)3.66448919
53interkinetic nuclear migration (GO:0022027)3.65596891
547-methylguanosine mRNA capping (GO:0006370)3.63734218
55regulation of nuclear cell cycle DNA replication (GO:0033262)3.63481005
56maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.63320344
57regulation of double-strand break repair via homologous recombination (GO:0010569)3.61435931
58attachment of spindle microtubules to kinetochore (GO:0008608)3.61129160
59RNA capping (GO:0036260)3.60584103
607-methylguanosine RNA capping (GO:0009452)3.60584103
61atrioventricular valve morphogenesis (GO:0003181)3.59730426
62maturation of 5.8S rRNA (GO:0000460)3.58876168
63transcription initiation from RNA polymerase I promoter (GO:0006361)3.58270030
64nodal signaling pathway (GO:0038092)3.58230460
65kinetochore assembly (GO:0051382)3.56530704
66oocyte maturation (GO:0001556)3.55769831
67DNA-templated transcription, elongation (GO:0006354)3.55633765
68DNA methylation involved in gamete generation (GO:0043046)3.54643247
69blastocyst development (GO:0001824)3.53347457
70synaptonemal complex organization (GO:0070193)3.50401545
71mitotic spindle checkpoint (GO:0071174)3.50155984
72transcription elongation from RNA polymerase II promoter (GO:0006368)3.49227975
73histone H3-K9 methylation (GO:0051567)3.48717230
74lung-associated mesenchyme development (GO:0060484)3.48374571
75DNA replication-independent nucleosome organization (GO:0034724)3.45850351
76DNA replication-independent nucleosome assembly (GO:0006336)3.45850351
77synapsis (GO:0007129)3.43784514
78folic acid transport (GO:0015884)3.42987606
79histone exchange (GO:0043486)3.42450628
80nuclear envelope disassembly (GO:0051081)3.41909055
81membrane disassembly (GO:0030397)3.41909055
82negative regulation of fibroblast apoptotic process (GO:2000270)3.39757711
83snRNA transcription (GO:0009301)3.39228016
84establishment of protein localization to Golgi (GO:0072600)3.37818886
85peptidyl-lysine methylation (GO:0018022)3.36729501
86CENP-A containing nucleosome assembly (GO:0034080)3.36654228
87chromosome organization involved in meiosis (GO:0070192)3.36018507
88regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.34971658
89regulation of mitotic spindle checkpoint (GO:1903504)3.34971658
90DNA damage response, signal transduction resulting in transcription (GO:0042772)3.34675729
91regulation of nucleobase-containing compound transport (GO:0032239)3.34501602
92regulation of mitotic metaphase/anaphase transition (GO:0030071)3.34301864
93peptidyl-lysine trimethylation (GO:0018023)3.32728314
94negative regulation of chromosome segregation (GO:0051985)3.32719171
95somatic diversification of immune receptors via somatic mutation (GO:0002566)3.32424861
96somatic hypermutation of immunoglobulin genes (GO:0016446)3.32424861
97positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.30967940
98positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.30967940
99positive regulation of mitotic sister chromatid separation (GO:1901970)3.30967940
100embryonic body morphogenesis (GO:0010172)3.30555487
101negative regulation of DNA-dependent DNA replication (GO:2000104)3.30274482
102meiotic chromosome segregation (GO:0045132)3.29229487
103histone H2A monoubiquitination (GO:0035518)3.26646283
104regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.26321951
105mitotic spindle assembly checkpoint (GO:0007094)3.24302620
106negative regulation of mitotic sister chromatid separation (GO:2000816)3.24142971
107negative regulation of mitotic sister chromatid segregation (GO:0033048)3.24142971
108negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.24142971
109negative regulation of sister chromatid segregation (GO:0033046)3.24142971
110regulation of establishment of cell polarity (GO:2000114)3.23431988
111chromatin remodeling at centromere (GO:0031055)3.23220054
112spleen development (GO:0048536)3.22479795
113intestinal epithelial cell development (GO:0060576)3.22432003
114regulation of transcription from RNA polymerase I promoter (GO:0006356)3.22068493
115spindle assembly checkpoint (GO:0071173)3.20671982
116ribonucleoprotein complex biogenesis (GO:0022613)3.19492769
117rRNA methylation (GO:0031167)3.17641517
118chromosome segregation (GO:0007059)3.17090244
119kinetochore organization (GO:0051383)3.16316351
120regulation of skeletal muscle contraction (GO:0014819)3.14335112
121negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.14114817
122reciprocal meiotic recombination (GO:0007131)3.13796846
123reciprocal DNA recombination (GO:0035825)3.13796846
124negative regulation of DNA-templated transcription, elongation (GO:0032785)3.13308508
125negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.13308508
126DNA replication initiation (GO:0006270)3.12971204
127protein localization to Golgi apparatus (GO:0034067)3.12414111
128positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)3.11451492
129replicative senescence (GO:0090399)3.10448397
130regulation of mitotic sister chromatid segregation (GO:0033047)3.10020051
131regulation of translation, ncRNA-mediated (GO:0045974)3.08302182
132negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.08302182
133negative regulation of translation, ncRNA-mediated (GO:0040033)3.08302182
134negative regulation of gluconeogenesis (GO:0045721)3.07796778
135DNA synthesis involved in DNA repair (GO:0000731)3.03842806
136prenylation (GO:0097354)3.01300351
137protein prenylation (GO:0018342)3.01300351
138retinal cone cell development (GO:0046549)3.00785379
139protein K11-linked deubiquitination (GO:0035871)2.98252285
140DNA strand renaturation (GO:0000733)2.97246872
141protein K48-linked deubiquitination (GO:0071108)2.97049290
142histone lysine methylation (GO:0034968)2.95142262
143ventricular septum development (GO:0003281)2.94927083
144epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.86914475
145protein import into peroxisome matrix (GO:0016558)2.85465046
146cellular ketone body metabolic process (GO:0046950)2.85211484
147female gamete generation (GO:0007292)2.84398311
148cellular response to ethanol (GO:0071361)2.81414509
149embryonic axis specification (GO:0000578)2.81310124
150basement membrane organization (GO:0071711)2.79733897
151histone H3-K9 modification (GO:0061647)2.77288951
152flavonoid metabolic process (GO:0009812)2.75416069
153oxidative demethylation (GO:0070989)2.75267264
154positive regulation of developmental pigmentation (GO:0048087)2.73566788
155gene silencing by RNA (GO:0031047)2.71347138
156histone H3-K4 trimethylation (GO:0080182)2.70735374
157atrial septum morphogenesis (GO:0060413)2.70431202
158response to pheromone (GO:0019236)2.70050600
159negative regulation of Rho protein signal transduction (GO:0035024)2.67059808
160detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.66680273
161sphingoid metabolic process (GO:0046519)2.66545679
162mRNA cleavage (GO:0006379)2.64350708
163double-strand break repair via homologous recombination (GO:0000724)2.62578924
164recombinational repair (GO:0000725)2.61009936
165anterior/posterior axis specification, embryo (GO:0008595)2.60827901
166rRNA catabolic process (GO:0016075)2.60371170
167meiotic cell cycle process (GO:1903046)2.59017388
168positive regulation of protein kinase C signaling (GO:0090037)2.58897176
169homocysteine metabolic process (GO:0050667)2.56618399
170regulation of posttranscriptional gene silencing (GO:0060147)2.56464663
171regulation of gene silencing by miRNA (GO:0060964)2.56464663
172regulation of gene silencing by RNA (GO:0060966)2.56464663
173protein K63-linked deubiquitination (GO:0070536)2.56108817
174DNA alkylation (GO:0006305)2.54492659
175DNA methylation (GO:0006306)2.54492659
176oocyte development (GO:0048599)2.54386732
177cellular response to exogenous dsRNA (GO:0071360)2.50090264
178cardiac septum development (GO:0003279)2.49365281
179DNA methylation or demethylation (GO:0044728)2.49292292
180regulation of DNA endoreduplication (GO:0032875)2.48420453
181protein targeting to Golgi (GO:0000042)2.48220474
182meiotic nuclear division (GO:0007126)2.45977605
183behavioral response to nicotine (GO:0035095)2.45334046
184histone phosphorylation (GO:0016572)2.44929275
185positive regulation of cell cycle checkpoint (GO:1901978)2.44389082
186DNA modification (GO:0006304)2.44388316

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.30513131
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.45134297
3FOXM1_23109430_ChIP-Seq_U2OS_Human5.43762618
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.07593289
5ZNF274_21170338_ChIP-Seq_K562_Hela3.79140097
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.52312208
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.42718985
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.40335242
9MYC_18555785_ChIP-Seq_MESCs_Mouse3.24896966
10AR_21909140_ChIP-Seq_LNCAP_Human3.18600658
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.18128566
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.16933447
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.14793275
14CREB1_15753290_ChIP-ChIP_HEK293T_Human3.12209092
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.86490450
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.82440721
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.62917199
18KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.62734300
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.56218910
20EWS_26573619_Chip-Seq_HEK293_Human2.53439623
21EGR1_23403033_ChIP-Seq_LIVER_Mouse2.45774771
22MYC_19030024_ChIP-ChIP_MESCs_Mouse2.35979942
23EST1_17652178_ChIP-ChIP_JURKAT_Human2.32843865
24TP63_19390658_ChIP-ChIP_HaCaT_Human2.29172548
25MYC_18358816_ChIP-ChIP_MESCs_Mouse2.22030079
26STAT6_21828071_ChIP-Seq_BEAS2B_Human2.16719344
27VDR_23849224_ChIP-Seq_CD4+_Human2.13605208
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.13237700
29MYCN_18555785_ChIP-Seq_MESCs_Mouse2.12307487
30NELFA_20434984_ChIP-Seq_ESCs_Mouse2.10764827
31NANOG_18555785_ChIP-Seq_MESCs_Mouse2.04990361
32E2F1_21310950_ChIP-Seq_MCF-7_Human2.04342354
33KAP1_22055183_ChIP-Seq_ESCs_Mouse1.94634402
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.91380060
35CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.90551157
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.90306571
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.89171082
38XRN2_22483619_ChIP-Seq_HELA_Human1.88106735
39TP53_16413492_ChIP-PET_HCT116_Human1.83416917
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.83132945
41GABP_19822575_ChIP-Seq_HepG2_Human1.82761305
42BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.82632999
43KDM5A_27292631_Chip-Seq_BREAST_Human1.79876981
44IRF1_19129219_ChIP-ChIP_H3396_Human1.77993923
45AR_21572438_ChIP-Seq_LNCaP_Human1.77720203
46FUS_26573619_Chip-Seq_HEK293_Human1.76618859
47PKCTHETA_26484144_Chip-Seq_BREAST_Human1.74645733
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.69008339
49FOXP3_21729870_ChIP-Seq_TREG_Human1.66970077
50HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.64646212
51ZNF263_19887448_ChIP-Seq_K562_Human1.59255068
52ER_23166858_ChIP-Seq_MCF-7_Human1.56620373
53CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.55975510
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.55816286
55POU3F2_20337985_ChIP-ChIP_501MEL_Human1.55272152
56GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53750583
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52773244
58EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.52154506
59YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51561406
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49547521
61KLF4_18555785_ChIP-Seq_MESCs_Mouse1.49422282
62YY1_21170310_ChIP-Seq_MESCs_Mouse1.48322402
63VDR_22108803_ChIP-Seq_LS180_Human1.47546271
64RXR_22108803_ChIP-Seq_LS180_Human1.46128701
65CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.42897099
66CBP_20019798_ChIP-Seq_JUKART_Human1.42548173
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42548173
68AHR_22903824_ChIP-Seq_MCF-7_Human1.40842764
69FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.37645078
70E2F1_18555785_ChIP-Seq_MESCs_Mouse1.37332885
71CTBP2_25329375_ChIP-Seq_LNCAP_Human1.37176643
72ZFP57_27257070_Chip-Seq_ESCs_Mouse1.35524053
73TTF2_22483619_ChIP-Seq_HELA_Human1.35107985
74CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.33994176
75EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.32882850
76DCP1A_22483619_ChIP-Seq_HELA_Human1.32212423
77STAT3_23295773_ChIP-Seq_U87_Human1.30747757
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29674421
79HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.28669562
80PADI4_21655091_ChIP-ChIP_MCF-7_Human1.26438792
81VDR_21846776_ChIP-Seq_THP-1_Human1.24815253
82AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23431604
83STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.21761068
84ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.20899446
85THAP11_20581084_ChIP-Seq_MESCs_Mouse1.20169773
86NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.18937324
87ERA_21632823_ChIP-Seq_H3396_Human1.17480943
88GATA3_21878914_ChIP-Seq_MCF-7_Human1.16423774
89DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15623270
90FLI1_27457419_Chip-Seq_LIVER_Mouse1.15191608
91NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14483840
92TCF4_22108803_ChIP-Seq_LS180_Human1.13282336
93ZFX_18555785_ChIP-Seq_MESCs_Mouse1.12387497
94NANOG_21062744_ChIP-ChIP_HESCs_Human1.11958436
95TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11889916
96STAT3_1855785_ChIP-Seq_MESCs_Mouse1.11119056
97E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11004683
98CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.10471396
99CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.10439803
100NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.09141474
101TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07772460
102JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07675707
103BCAT_22108803_ChIP-Seq_LS180_Human1.07299954
104CIITA_25753668_ChIP-Seq_RAJI_Human1.06449987
105POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.04639939
106ELK1_19687146_ChIP-ChIP_HELA_Human1.03731787
107CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.03218868
108ARNT_22903824_ChIP-Seq_MCF-7_Human1.01667951
109FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.01273720
110EGR1_19374776_ChIP-ChIP_THP-1_Human1.00985907
111ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00674530
112KAP1_27257070_Chip-Seq_ESCs_Mouse1.00268570
113SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.99353648
114P300_19829295_ChIP-Seq_ESCs_Human0.98762405
115BRD4_25478319_ChIP-Seq_HGPS_Human0.97042638
116POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96934076
117TAF15_26573619_Chip-Seq_HEK293_Human0.96903350
118TP53_22573176_ChIP-Seq_HFKS_Human0.96606159
119MAF_26560356_Chip-Seq_TH2_Human0.94843235
120IRF8_22096565_ChIP-ChIP_GC-B_Human0.94360032
121CTBP1_25329375_ChIP-Seq_LNCAP_Human0.93415680
122HOXB7_26014856_ChIP-Seq_BT474_Human0.93077917
123SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92579901
124SCL_19346495_ChIP-Seq_HPC-7_Human0.92277774
125SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.89563810
126TCF4_23295773_ChIP-Seq_U87_Human0.89094955
127SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88712780
128ELK1_22589737_ChIP-Seq_MCF10A_Human0.87600387
129NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.87003217
130E2F1_17053090_ChIP-ChIP_MCF-7_Human0.86978275
131SMAD4_21799915_ChIP-Seq_A2780_Human0.86531716
132DROSHA_22980978_ChIP-Seq_HELA_Human0.86444492
133TP53_22127205_ChIP-Seq_IMR90_Human0.86162035
134TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.85642030
135ETV2_25802403_ChIP-Seq_MESCs_Mouse0.85267106
136FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.84424583
137PRDM14_20953172_ChIP-Seq_ESCs_Human0.83865947
138OCT4_20526341_ChIP-Seq_ESCs_Human0.83522974
139TP53_18474530_ChIP-ChIP_U2OS_Human0.83268283
140CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.83129683
141PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.82749713
142HOXB4_20404135_ChIP-ChIP_EML_Mouse0.82613777
143LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82542203
144SRF_21415370_ChIP-Seq_HL-1_Mouse0.82350871
145SOX2_18555785_ChIP-Seq_MESCs_Mouse0.82007202
146CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.81995463
147MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.81847452
148HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.81690820
149WDR5_24793694_ChIP-Seq_LNCAP_Human0.81498315
150BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.81259318
151ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.80940807
152NCOR_22424771_ChIP-Seq_293T_Human0.79937299
153ZNF217_24962896_ChIP-Seq_MCF-7_Human0.79932440
154POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.79709533
155IGF1R_20145208_ChIP-Seq_DFB_Human0.79072530
156AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.78918186
157TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.78725050
158PCGF2_27294783_Chip-Seq_ESCs_Mouse0.77923086
159SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.77900245
160MYC_18940864_ChIP-ChIP_HL60_Human0.77298227
161TCF3_18692474_ChIP-Seq_MESCs_Mouse0.77176320
162POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.76350807
163SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.74401282
164PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.72684217
165SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.72503670
166GATA1_26923725_Chip-Seq_HPCs_Mouse0.71898015
167KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.71772589
168SOX2_18692474_ChIP-Seq_MESCs_Mouse0.69095783
169RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.68197595
170NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.64774091
171EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.62214660
172MYC_22102868_ChIP-Seq_BL_Human0.61649168
173NANOG_18692474_ChIP-Seq_MESCs_Mouse0.61155395

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.23003419
2MP0003111_abnormal_nucleus_morphology4.93222999
3MP0010094_abnormal_chromosome_stability4.02441069
4MP0008057_abnormal_DNA_replication3.94453234
5MP0000569_abnormal_digit_pigmentation3.92506265
6MP0002254_reproductive_system_inflammat3.91552128
7MP0003077_abnormal_cell_cycle3.81559547
8MP0003718_maternal_effect3.81254879
9MP0005174_abnormal_tail_pigmentation3.63258851
10MP0004957_abnormal_blastocyst_morpholog3.62959362
11MP0003283_abnormal_digestive_organ3.50287691
12MP0008877_abnormal_DNA_methylation3.43055529
13MP0005171_absent_coat_pigmentation3.20957915
14MP0008058_abnormal_DNA_repair3.13492594
15MP0005451_abnormal_body_composition3.12732730
16MP0001348_abnormal_lacrimal_gland2.91454871
17MP0008260_abnormal_autophagy2.89031420
18MP0001986_abnormal_taste_sensitivity2.79013324
19MP0008007_abnormal_cellular_replicative2.72767980
20MP0003123_paternal_imprinting2.67532356
21MP0001730_embryonic_growth_arrest2.54983727
22MP0003786_premature_aging2.44437231
23MP0000015_abnormal_ear_pigmentation2.40828024
24MP0005503_abnormal_tendon_morphology2.33699453
25MP0000427_abnormal_hair_cycle2.25950467
26MP0010307_abnormal_tumor_latency2.21292106
27MP0000350_abnormal_cell_proliferation2.11282358
28MP0002876_abnormal_thyroid_physiology2.10242690
29MP0002638_abnormal_pupillary_reflex2.04947298
30MP0001672_abnormal_embryogenesis/_devel2.04822788
31MP0005380_embryogenesis_phenotype2.04822788
32MP0008932_abnormal_embryonic_tissue2.04390986
33MP0004133_heterotaxia2.03810619
34MP0002210_abnormal_sex_determination1.94260415
35MP0005423_abnormal_somatic_nervous1.93827066
36MP0004043_abnormal_pH_regulation1.89310536
37MP0002102_abnormal_ear_morphology1.86958284
38MP0008995_early_reproductive_senescence1.86364265
39MP0001661_extended_life_span1.76642067
40MP0003984_embryonic_growth_retardation1.74878216
41MP0006292_abnormal_olfactory_placode1.71797627
42MP0002088_abnormal_embryonic_growth/wei1.69687163
43MP0002396_abnormal_hematopoietic_system1.69427655
44MP0001929_abnormal_gametogenesis1.69194465
45MP0002163_abnormal_gland_morphology1.65370741
46MP0001697_abnormal_embryo_size1.61752605
47MP0001145_abnormal_male_reproductive1.60618782
48MP0005377_hearing/vestibular/ear_phenot1.52674056
49MP0003878_abnormal_ear_physiology1.52674056
50MP0000653_abnormal_sex_gland1.52426979
51MP0003221_abnormal_cardiomyocyte_apopto1.51846619
52MP0002085_abnormal_embryonic_tissue1.51558496
53MP0004381_abnormal_hair_follicle1.48718663
54MP0009840_abnormal_foam_cell1.47644341
55MP0003938_abnormal_ear_development1.44126868
56MP0005367_renal/urinary_system_phenotyp1.42914486
57MP0000516_abnormal_urinary_system1.42914486
58MP0002080_prenatal_lethality1.42139114
59MP0003195_calcinosis1.41771562
60MP0002084_abnormal_developmental_patter1.40601287
61MP0009333_abnormal_splenocyte_physiolog1.39116289
62MP0005551_abnormal_eye_electrophysiolog1.37642038
63MP0003315_abnormal_perineum_morphology1.37118225
64MP0003937_abnormal_limbs/digits/tail_de1.36205432
65MP0005257_abnormal_intraocular_pressure1.33747585
66MP0002837_dystrophic_cardiac_calcinosis1.33472535
67MP0009672_abnormal_birth_weight1.31309876
68MP0010030_abnormal_orbit_morphology1.31256497
69MP0002086_abnormal_extraembryonic_tissu1.28672716
70MP0005395_other_phenotype1.27964325
71MP0005253_abnormal_eye_physiology1.25139230
72MP0000470_abnormal_stomach_morphology1.19724548
73MP0003950_abnormal_plasma_membrane1.19264742
74MP0000383_abnormal_hair_follicle1.16779696
75MP0001119_abnormal_female_reproductive1.15022477
76MP0008961_abnormal_basal_metabolism1.14689082
77MP0003699_abnormal_female_reproductive1.13871292
78MP0004185_abnormal_adipocyte_glucose1.13862954
79MP0001545_abnormal_hematopoietic_system1.13469925
80MP0005397_hematopoietic_system_phenotyp1.13469925
81MP0001968_abnormal_touch/_nociception1.13284189
82MP0008872_abnormal_physiological_respon1.10204682
83MP0000013_abnormal_adipose_tissue1.08649260
84MP0005083_abnormal_biliary_tract1.07343360
85MP0003698_abnormal_male_reproductive1.07171121
86MP0001346_abnormal_lacrimal_gland1.06214068
87MP0003567_abnormal_fetal_cardiomyocyte1.05014187
88MP0001873_stomach_inflammation1.03135818
89MP0005646_abnormal_pituitary_gland1.02405741
90MP0000313_abnormal_cell_death1.01829681
91MP0009250_abnormal_appendicular_skeleto0.99442510
92MP0000750_abnormal_muscle_regeneration0.97457899
93MP0002161_abnormal_fertility/fecundity0.94512998
94MP0002653_abnormal_ependyma_morphology0.94235784
95MP0004130_abnormal_muscle_cell0.93679706
96MP0009046_muscle_twitch0.91955348
97MP0004808_abnormal_hematopoietic_stem0.89654393
98MP0003121_genomic_imprinting0.88542241
99MP0002108_abnormal_muscle_morphology0.88235922
100MP0003136_yellow_coat_color0.87889761
101MP0000428_abnormal_craniofacial_morphol0.87509911
102MP0009703_decreased_birth_body0.87029911
103MP0005621_abnormal_cell_physiology0.86683486
104MP0005408_hypopigmentation0.85627344
105MP0005275_abnormal_skin_tensile0.84952604
106MP0005310_abnormal_salivary_gland0.84280949
107MP0002009_preneoplasia0.83766250
108MP0000490_abnormal_crypts_of0.83343116
109MP0002019_abnormal_tumor_incidence0.82623749
110MP0001243_abnormal_dermal_layer0.82398413
111MP0000647_abnormal_sebaceous_gland0.82155676
112MP0004197_abnormal_fetal_growth/weight/0.81472412
113MP0000627_abnormal_mammary_gland0.80672881
114MP0001849_ear_inflammation0.80085379
115MP0002132_abnormal_respiratory_system0.79175417
116MP0004134_abnormal_chest_morphology0.77797815
117MP0002160_abnormal_reproductive_system0.76960705
118MP0005076_abnormal_cell_differentiation0.74207886
119MP0003828_pulmonary_edema0.72632530
120MP0005384_cellular_phenotype0.72394919
121MP0002928_abnormal_bile_duct0.72239139
122MP0008770_decreased_survivor_rate0.71883291
123MP0010678_abnormal_skin_adnexa0.71858549
124MP0002938_white_spotting0.71665873
125MP0004885_abnormal_endolymph0.71659291
126MP0005220_abnormal_exocrine_pancreas0.71505106
127MP0000566_synostosis0.71036265
128MP0001293_anophthalmia0.69726848
129MP0005379_endocrine/exocrine_gland_phen0.68171379
130MP0004264_abnormal_extraembryonic_tissu0.67503034
131MP0000462_abnormal_digestive_system0.66682733
132MP0002095_abnormal_skin_pigmentation0.66660982
133MP0000538_abnormal_urinary_bladder0.66252906
134MP0003936_abnormal_reproductive_system0.65479915
135MP0002909_abnormal_adrenal_gland0.65097052
136MP0003119_abnormal_digestive_system0.64984967
137MP0005266_abnormal_metabolism0.64676154
138MP0003935_abnormal_craniofacial_develop0.64334884
139MP0003943_abnormal_hepatobiliary_system0.64269891
140MP0004019_abnormal_vitamin_homeostasis0.64210671
141MP0005332_abnormal_amino_acid0.63741043
142MP0003755_abnormal_palate_morphology0.63140664
143MP0002114_abnormal_axial_skeleton0.63029763
144MP0005410_abnormal_fertilization0.62643734
145MP0002109_abnormal_limb_morphology0.62506640
146MP0001502_abnormal_circadian_rhythm0.62237715
147MP0005647_abnormal_sex_gland0.61631706
148MP0000371_diluted_coat_color0.61049056
149MP0002092_abnormal_eye_morphology0.60598947
150MP0000358_abnormal_cell_content/0.60567201
151MP0000432_abnormal_head_morphology0.60181421
152MP0003890_abnormal_embryonic-extraembry0.60068585
153MP0002075_abnormal_coat/hair_pigmentati0.58912695
154MP0005389_reproductive_system_phenotype0.58364637
155MP0001542_abnormal_bone_strength0.58171090
156MP0008775_abnormal_heart_ventricle0.58015990
157MP0001188_hyperpigmentation0.57070419
158MP0001191_abnormal_skin_condition0.56602971
159MP0002127_abnormal_cardiovascular_syste0.56152091
160MP0001727_abnormal_embryo_implantation0.55186943
161MP0003646_muscle_fatigue0.54012050

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.75502143
2Impulsivity (HP:0100710)5.33518239
3Breast hypoplasia (HP:0003187)5.11867285
4Hyperglycinemia (HP:0002154)4.67279097
5Aplasia of the musculature (HP:0100854)4.58293578
6Chromosomal breakage induced by crosslinking agents (HP:0003221)4.57316768
7Carpal bone hypoplasia (HP:0001498)4.33096103
8Chromsome breakage (HP:0040012)4.28804238
9Rib fusion (HP:0000902)4.22548502
10Patellar aplasia (HP:0006443)4.21372803
11Facial hemangioma (HP:0000329)4.16148319
12Aplasia/Hypoplasia of the patella (HP:0006498)4.09404049
13Ulnar bowing (HP:0003031)3.83998824
14Abnormality of the labia minora (HP:0012880)3.77509472
15Capillary hemangiomas (HP:0005306)3.62191185
16Hyperglycinuria (HP:0003108)3.58997238
17Entropion (HP:0000621)3.57281613
18Ureteral duplication (HP:0000073)3.42140315
19Cerebral hypomyelination (HP:0006808)3.39855438
20Long clavicles (HP:0000890)3.34812818
21Rough bone trabeculation (HP:0100670)3.34417008
22Abnormality of the preputium (HP:0100587)3.34212388
23Abnormal spermatogenesis (HP:0008669)3.32338089
24Molar tooth sign on MRI (HP:0002419)3.30792576
25Abnormality of midbrain morphology (HP:0002418)3.30792576
26Increased circulating renin level (HP:0000848)3.28542420
27Meckel diverticulum (HP:0002245)3.26687299
28Azoospermia (HP:0000027)3.23266554
29Abnormal drinking behavior (HP:0030082)3.21090456
30Polydipsia (HP:0001959)3.21090456
31Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.18769186
32Poikiloderma (HP:0001029)3.18452864
33Attenuation of retinal blood vessels (HP:0007843)3.18345417
34Oligodactyly (hands) (HP:0001180)3.15774187
35Congenital stationary night blindness (HP:0007642)3.14754269
36Atrioventricular block (HP:0001678)3.10313667
37Abnormality of DNA repair (HP:0003254)3.06341377
38Abnormality of chromosome stability (HP:0003220)3.04443339
39Prostate neoplasm (HP:0100787)3.01676731
40Abnormality of the ileum (HP:0001549)2.97935970
41Aplasia/Hypoplasia of the uvula (HP:0010293)2.97728117
42Chronic hepatic failure (HP:0100626)2.96193237
43Genetic anticipation (HP:0003743)2.92929440
44Oligodactyly (HP:0012165)2.92500817
45Gout (HP:0001997)2.92176714
46Absent radius (HP:0003974)2.88440106
47Abnormality of glycine metabolism (HP:0010895)2.79301488
48Abnormality of serine family amino acid metabolism (HP:0010894)2.79301488
49Aplasia involving forearm bones (HP:0009822)2.73744634
50Absent forearm bone (HP:0003953)2.73744634
51Duplicated collecting system (HP:0000081)2.73711701
52Sparse lateral eyebrow (HP:0005338)2.72790516
53Small hand (HP:0200055)2.71783680
54Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.70612450
55Neonatal respiratory distress (HP:0002643)2.70201267
56Tetraplegia (HP:0002445)2.68523084
57Breast aplasia (HP:0100783)2.65592095
58Lip pit (HP:0100267)2.65386328
59Hypoplasia of the capital femoral epiphysis (HP:0003090)2.63255435
60Prominent nose (HP:0000448)2.61451662
61Abnormal trabecular bone morphology (HP:0100671)2.60124131
62Abnormality of the renal collecting system (HP:0004742)2.59932702
63Male infertility (HP:0003251)2.57058977
64Bony spicule pigmentary retinopathy (HP:0007737)2.56334755
65Secondary amenorrhea (HP:0000869)2.56103053
66Hypoplastic nipples (HP:0002557)2.54031117
67Intestinal fistula (HP:0100819)2.53600391
68Mutism (HP:0002300)2.53344985
69Asplenia (HP:0001746)2.52759936
70CNS hypomyelination (HP:0003429)2.51812284
71Aplasia/Hypoplasia of the breasts (HP:0010311)2.50066556
72Increased number of teeth (HP:0011069)2.48855680
73Clumsiness (HP:0002312)2.45468045
74Ectopic kidney (HP:0000086)2.44898435
75Small epiphyses (HP:0010585)2.44544598
76Shawl scrotum (HP:0000049)2.42300673
77Pancreatic cysts (HP:0001737)2.40725181
78Multiple enchondromatosis (HP:0005701)2.39690853
79Aplasia/Hypoplasia of the spleen (HP:0010451)2.39150136
80Small intestinal stenosis (HP:0012848)2.38015633
81Duodenal stenosis (HP:0100867)2.38015633
82Flat capital femoral epiphysis (HP:0003370)2.37167212
83Hyperventilation (HP:0002883)2.36799808
84Aplasia/Hypoplasia involving the musculature (HP:0001460)2.33919764
85Areflexia of lower limbs (HP:0002522)2.33172437
86Abnormality of the frontal sinuses (HP:0002687)2.32522387
87Increased neuronal autofluorescent lipopigment (HP:0002074)2.32471937
88Protruding tongue (HP:0010808)2.32369750
89Short thumb (HP:0009778)2.31820982
90Adrenal hypoplasia (HP:0000835)2.31263356
91Abnormality of incisor morphology (HP:0011063)2.31189606
92Horseshoe kidney (HP:0000085)2.30804143
93Rectovaginal fistula (HP:0000143)2.28051761
94Rectal fistula (HP:0100590)2.28051761
95Progressive muscle weakness (HP:0003323)2.27797936
96Premature ovarian failure (HP:0008209)2.26880428
97Gaze-evoked nystagmus (HP:0000640)2.26858155
98Absent speech (HP:0001344)2.26552303
99Muscle fiber splitting (HP:0003555)2.26530734
100Abnormality of the nasal septum (HP:0000419)2.25622266
101Nephronophthisis (HP:0000090)2.24846221
102Bundle branch block (HP:0011710)2.24195827
103Oral leukoplakia (HP:0002745)2.22788057
104Hypokalemic alkalosis (HP:0001949)2.20657178
105Pelvic girdle muscle weakness (HP:0003749)2.18562525
106Bone marrow hypocellularity (HP:0005528)2.18531110
107Abnormality of the labia majora (HP:0012881)2.16391617
108Tented upper lip vermilion (HP:0010804)2.15034831
109Fair hair (HP:0002286)2.14905325
110Abnormality of serum amino acid levels (HP:0003112)2.13259559
111Abnormality of the proximal phalanges of the hand (HP:0009834)2.12189678
112Pancreatic fibrosis (HP:0100732)2.11404779
113Abnormality of the umbilical cord (HP:0010881)2.10071766
114Cerebellar dysplasia (HP:0007033)2.09563352
115Truncal obesity (HP:0001956)2.09039587
116Aplasia/Hypoplasia of the earlobes (HP:0009906)2.08657031
117Polyuria (HP:0000103)2.08622200
118Death in infancy (HP:0001522)2.06421788
119Tetany (HP:0001281)2.05862645
120Short chin (HP:0000331)2.05676970
121Widely spaced teeth (HP:0000687)2.05633028
122Hypoplasia of the pons (HP:0012110)2.04265640
123Pustule (HP:0200039)2.03454183
124Hypoplastic iliac wings (HP:0002866)2.02608902
125Abnormality of lateral ventricle (HP:0030047)2.02358035
126Irregular epiphyses (HP:0010582)2.02331509
127Abnormal biliary tract physiology (HP:0012439)2.02159406
128Bile duct proliferation (HP:0001408)2.02159406
129Papillary thyroid carcinoma (HP:0002895)2.00640342
130Myelodysplasia (HP:0002863)2.00585345
131Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.99027306
132Absent epiphyses (HP:0010577)1.99027306
133Ventricular fibrillation (HP:0001663)1.97657918
134Duplication of thumb phalanx (HP:0009942)1.97648631
135Abnormality of the pons (HP:0007361)1.97386836
136Abnormality of the carotid arteries (HP:0005344)1.95080690
137Narrow palate (HP:0000189)1.94413973
138Amelogenesis imperfecta (HP:0000705)1.93884637
139Shoulder girdle muscle weakness (HP:0003547)1.93759860
140Overlapping toe (HP:0001845)1.92880081
141Disproportionate short-trunk short stature (HP:0003521)1.92790412
142Segmental peripheral demyelination/remyelination (HP:0003481)1.92589263
143Hypoplasia of the radius (HP:0002984)1.90710668
144Global brain atrophy (HP:0002283)1.88205108
145Radial bowing (HP:0002986)1.88027848
146Tracheoesophageal fistula (HP:0002575)1.86326298
147Heart block (HP:0012722)1.85403374
148Squamous cell carcinoma (HP:0002860)1.84454343
149Abnormality of the duodenum (HP:0002246)1.84434704
150Stillbirth (HP:0003826)1.84075229
151Sloping forehead (HP:0000340)1.83876835
152Degeneration of anterior horn cells (HP:0002398)1.82319361
153Abnormality of the anterior horn cell (HP:0006802)1.82319361
154Tubular atrophy (HP:0000092)1.82147403
155Choanal atresia (HP:0000453)1.82082626
156Clubbing of toes (HP:0100760)1.81640265
157Abnormality of the renal medulla (HP:0100957)1.80752085
158Microtia (HP:0008551)1.80497318
159Broad-based gait (HP:0002136)1.80390171
160Abnormality of renin-angiotensin system (HP:0000847)1.80323116
161Aplasia/Hypoplasia of the tibia (HP:0005772)1.79582269
162Partial agenesis of the corpus callosum (HP:0001338)1.79378753
163Anal stenosis (HP:0002025)1.79117494
164Abnormality of dental color (HP:0011073)1.78635978
165Osteolytic defects of the hand bones (HP:0009699)1.78048609
166Osteolytic defects of the phalanges of the hand (HP:0009771)1.78048609
167Basal cell carcinoma (HP:0002671)1.77354396
168Short phalanx of the thumb (HP:0009660)1.77267386
169Bowed forearm bones (HP:0003956)1.76169659
170Bowing of the arm (HP:0006488)1.76169659
171Abnormality of the musculature of the pelvis (HP:0001469)1.75362714
172Abnormality of the hip-girdle musculature (HP:0001445)1.75362714
173Absent thumb (HP:0009777)1.75116811
174Anteriorly placed anus (HP:0001545)1.74967357
175Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.73340553

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK46.38146872
2STK395.52292314
3BUB14.92925712
4OXSR14.46363091
5FRK4.42205186
6WEE14.02713397
7NEK23.75779941
8LATS23.66516354
9LATS13.15844688
10STK38L3.06537375
11BRSK22.94414306
12PLK42.90360085
13CDC72.86228779
14ACVR1B2.56507031
15SRPK12.56108151
16AKT32.52930060
17MAP4K22.44600927
18MKNK22.42017195
19STK32.38920203
20EIF2AK12.17769447
21DYRK32.16069582
22PLK12.15608613
23TTK2.15508336
24BRSK11.92611431
25CHEK21.91518494
26MAP2K71.90016555
27PLK31.84046762
28CDK121.70773114
29BMPR1B1.67506738
30TNIK1.65644050
31AURKB1.56610453
32MAP3K41.56449297
33MKNK11.53294665
34EIF2AK31.52040943
35GRK11.50651265
36CDK71.37358570
37CDK41.32725459
38CCNB11.31026843
39CHEK11.28612192
40NME21.27909459
41CAMK1D1.27576699
42CAMK1G1.26349237
43STK161.24396691
44PTK2B1.18771781
45TSSK61.18214036
46EPHA21.17037032
47TAOK11.11950835
48PINK11.10843302
49NEK11.06107234
50MAPK151.05821748
51CDK31.05391582
52ZAK1.05312425
53STK381.05099535
54NLK1.04386169
55ADRBK21.00036964
56CDK80.99554782
57PDK40.97194407
58PDK30.97194407
59RPS6KA40.95997286
60AURKA0.94209144
61PAK60.92665292
62RAF10.88765332
63ALK0.87456193
64ATR0.86207017
65PIM20.85736683
66CDK20.85290993
67BRAF0.83412971
68MELK0.81882636
69MARK30.81853484
70PRKCI0.78216066
71MAP2K40.77176121
72VRK10.76951043
73ATM0.76538866
74CSNK1G10.76278695
75IRAK30.75422944
76PRKAA10.74798153
77DYRK20.74680290
78ADRBK10.74439978
79EIF2AK20.74283151
80TRPM70.70422882
81CDK10.69004794
82STK240.68171122
83WNK10.66017069
84PDK20.65164908
85NUAK10.63786463
86PAK10.61499005
87TAOK30.61380057
88ICK0.60554455
89ERBB40.59680841
90PRKD20.59308334
91ABL20.58191817
92MAP3K60.56464208
93MAP3K80.55998641
94CSNK1G30.55994650
95STK110.54009633
96STK40.51380207
97CSNK1E0.48911584
98FLT30.48582674
99TNK20.48172559
100MTOR0.47380249
101KSR20.47333250
102CSNK1G20.46472733
103MAPK100.45832407
104SIK20.45269689
105PIM10.44656495
106CAMKK20.43849645
107KSR10.43797163
108CSNK1A1L0.42968644
109PRKAA20.42564250
110MAP3K90.40985090
111YES10.40721773
112TESK20.40208230
113PAK30.40095936
114SGK10.39835519
115WNK30.38597545
116AKT10.36284154
117PNCK0.36167285
118SGK20.36159538
119TEC0.35941209
120PDGFRB0.35796939
121BLK0.35672961
122BRD40.35140751
123CSNK2A20.34925917
124MARK20.34873754
125MAP2K30.34412069
126CASK0.34102437
127CHUK0.34008036
128IKBKB0.33701492
129ARAF0.32822657
130MAPK10.32055902
131CAMK40.30535079
132MAPK80.30369345
133MET0.30287736
134FGFR10.29579903
135CSNK2A10.29460556
136PDPK10.29088993
137DYRK1A0.28890774
138GSK3B0.28176049
139CAMK10.28152238
140RPS6KB10.27193337
141MAP3K50.26835270
142RPS6KA50.26778995
143INSRR0.26048198
144PBK0.25791359
145MAPK140.25711559
146TLK10.24922114
147BMX0.24790248
148PRKCH0.24547457
149RPS6KA60.24084674
150NEK60.24071620
151RET0.23556892
152PRKCG0.23334189
153CDK90.22921906
154MAPK110.22911662
155AKT20.22654551
156CSNK1A10.21807071
157CDK60.19369858
158PAK20.19249801

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007506.91799840
2RNA polymerase_Homo sapiens_hsa030204.97827784
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.97598362
4Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006044.13639636
5RNA transport_Homo sapiens_hsa030133.52699909
6Basal transcription factors_Homo sapiens_hsa030223.31654293
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.27140156
8Cell cycle_Homo sapiens_hsa041103.21665054
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.77829208
10Homologous recombination_Homo sapiens_hsa034402.50520986
11Fanconi anemia pathway_Homo sapiens_hsa034602.40366372
12Spliceosome_Homo sapiens_hsa030402.37311083
13Pyrimidine metabolism_Homo sapiens_hsa002402.26942914
14p53 signaling pathway_Homo sapiens_hsa041152.11612761
15DNA replication_Homo sapiens_hsa030302.11348490
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.05789513
17Regulation of autophagy_Homo sapiens_hsa041402.02575784
18Taste transduction_Homo sapiens_hsa047422.00442145
19mRNA surveillance pathway_Homo sapiens_hsa030151.93752177
20Alcoholism_Homo sapiens_hsa050341.83638237
21Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.75227587
22Vitamin digestion and absorption_Homo sapiens_hsa049771.75086670
23Nucleotide excision repair_Homo sapiens_hsa034201.73571280
24Mismatch repair_Homo sapiens_hsa034301.71944235
25Phototransduction_Homo sapiens_hsa047441.71810590
26Pentose phosphate pathway_Homo sapiens_hsa000301.69400906
27Folate biosynthesis_Homo sapiens_hsa007901.65429776
28Purine metabolism_Homo sapiens_hsa002301.63313328
29Nitrogen metabolism_Homo sapiens_hsa009101.59966665
30Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.59838421
31Glycerophospholipid metabolism_Homo sapiens_hsa005641.59084168
32Oocyte meiosis_Homo sapiens_hsa041141.57747654
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.54868502
34Proteasome_Homo sapiens_hsa030501.51954757
35RNA degradation_Homo sapiens_hsa030181.51828122
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.49634664
37Base excision repair_Homo sapiens_hsa034101.48280639
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.44831656
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.38498096
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31487151
41Basal cell carcinoma_Homo sapiens_hsa052171.28121463
42Primary bile acid biosynthesis_Homo sapiens_hsa001201.24035574
43Collecting duct acid secretion_Homo sapiens_hsa049661.19023933
44RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.17764371
45Epstein-Barr virus infection_Homo sapiens_hsa051691.14369987
46Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.14229442
47Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.07119952
48Arginine biosynthesis_Homo sapiens_hsa002201.05682401
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.05407553
50Drug metabolism - other enzymes_Homo sapiens_hsa009831.02323587
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.98598675
52Transcriptional misregulation in cancer_Homo sapiens_hsa052020.97451107
53Circadian rhythm_Homo sapiens_hsa047100.96858173
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.94114228
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.93733334
56Non-homologous end-joining_Homo sapiens_hsa034500.90787841
57Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.85383498
58Nicotine addiction_Homo sapiens_hsa050330.85050251
59Olfactory transduction_Homo sapiens_hsa047400.81756501
60Biosynthesis of amino acids_Homo sapiens_hsa012300.81440753
61Sulfur relay system_Homo sapiens_hsa041220.80814244
62Herpes simplex infection_Homo sapiens_hsa051680.80688036
63Fructose and mannose metabolism_Homo sapiens_hsa000510.80506425
64Calcium signaling pathway_Homo sapiens_hsa040200.79924264
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.78210510
66Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.70607792
67Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.69926592
68ABC transporters_Homo sapiens_hsa020100.67147856
69One carbon pool by folate_Homo sapiens_hsa006700.67146391
70MicroRNAs in cancer_Homo sapiens_hsa052060.65425485
71Glycosaminoglycan degradation_Homo sapiens_hsa005310.64847351
72Insulin resistance_Homo sapiens_hsa049310.62160533
73FoxO signaling pathway_Homo sapiens_hsa040680.59438873
74Chemical carcinogenesis_Homo sapiens_hsa052040.59201619
75Linoleic acid metabolism_Homo sapiens_hsa005910.58898000
76mTOR signaling pathway_Homo sapiens_hsa041500.58801780
77Other glycan degradation_Homo sapiens_hsa005110.56853780
78Lysosome_Homo sapiens_hsa041420.55595336
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.54831592
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54486282
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54172174
82Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.52219745
83Viral carcinogenesis_Homo sapiens_hsa052030.51724335
84Sphingolipid metabolism_Homo sapiens_hsa006000.49819658
85Renal cell carcinoma_Homo sapiens_hsa052110.48701068
86Small cell lung cancer_Homo sapiens_hsa052220.44918720
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44897944
88Inositol phosphate metabolism_Homo sapiens_hsa005620.41686374
89Primary immunodeficiency_Homo sapiens_hsa053400.40567196
90Selenocompound metabolism_Homo sapiens_hsa004500.40227491
91Hippo signaling pathway_Homo sapiens_hsa043900.39548505
92Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.39004716
93Type II diabetes mellitus_Homo sapiens_hsa049300.38841103
94TGF-beta signaling pathway_Homo sapiens_hsa043500.38649582
95Glutamatergic synapse_Homo sapiens_hsa047240.38438224
96Hepatitis C_Homo sapiens_hsa051600.37135654
97Ribosome_Homo sapiens_hsa030100.36691811
98Dorso-ventral axis formation_Homo sapiens_hsa043200.35909932
99Arginine and proline metabolism_Homo sapiens_hsa003300.35692228
100Cyanoamino acid metabolism_Homo sapiens_hsa004600.34117204
101Ether lipid metabolism_Homo sapiens_hsa005650.33923746
102Prostate cancer_Homo sapiens_hsa052150.33320061
103Choline metabolism in cancer_Homo sapiens_hsa052310.33098374
104Thyroid cancer_Homo sapiens_hsa052160.32965042
105NOD-like receptor signaling pathway_Homo sapiens_hsa046210.32266180
106Glycerolipid metabolism_Homo sapiens_hsa005610.32262839
107MAPK signaling pathway_Homo sapiens_hsa040100.31144238
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30604055
109Morphine addiction_Homo sapiens_hsa050320.29620695
110HTLV-I infection_Homo sapiens_hsa051660.29466681
111Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.28921863
112Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.28807046
113cAMP signaling pathway_Homo sapiens_hsa040240.28771036
114TNF signaling pathway_Homo sapiens_hsa046680.26193787
115Intestinal immune network for IgA production_Homo sapiens_hsa046720.25377691
116Antigen processing and presentation_Homo sapiens_hsa046120.24388582
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.23987240
118Arachidonic acid metabolism_Homo sapiens_hsa005900.22193923
119Metabolic pathways_Homo sapiens_hsa011000.21935008
120Hedgehog signaling pathway_Homo sapiens_hsa043400.18617264
121Prolactin signaling pathway_Homo sapiens_hsa049170.16416989
122Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.16351838
123Hepatitis B_Homo sapiens_hsa051610.14893858
124Influenza A_Homo sapiens_hsa051640.14428753
125Pancreatic cancer_Homo sapiens_hsa052120.12919053
126AMPK signaling pathway_Homo sapiens_hsa041520.12400587
127Tight junction_Homo sapiens_hsa045300.12109362
128Glutathione metabolism_Homo sapiens_hsa004800.11525797
129Mineral absorption_Homo sapiens_hsa049780.11439412
130Lysine degradation_Homo sapiens_hsa003100.09201399
131Colorectal cancer_Homo sapiens_hsa052100.09114774
132Butanoate metabolism_Homo sapiens_hsa006500.08577220
133Endometrial cancer_Homo sapiens_hsa052130.08406227
134Systemic lupus erythematosus_Homo sapiens_hsa053220.08304399
135Non-small cell lung cancer_Homo sapiens_hsa052230.07789206
136Jak-STAT signaling pathway_Homo sapiens_hsa046300.05843829
137Pathways in cancer_Homo sapiens_hsa052000.05281304
138beta-Alanine metabolism_Homo sapiens_hsa004100.04982825
139NF-kappa B signaling pathway_Homo sapiens_hsa040640.04515359
140HIF-1 signaling pathway_Homo sapiens_hsa040660.04360193
141Apoptosis_Homo sapiens_hsa042100.04192513
142Maturity onset diabetes of the young_Homo sapiens_hsa049500.03524562
143Phosphatidylinositol signaling system_Homo sapiens_hsa040700.02925160
144Ovarian steroidogenesis_Homo sapiens_hsa049130.02477355
145Melanoma_Homo sapiens_hsa052180.01953934

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