BTBD19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)5.24872226
2acrosome reaction (GO:0007340)4.72387713
3tryptophan catabolic process (GO:0006569)4.53330133
4indole-containing compound catabolic process (GO:0042436)4.53330133
5indolalkylamine catabolic process (GO:0046218)4.53330133
6regulation of nuclear cell cycle DNA replication (GO:0033262)4.37601618
7kynurenine metabolic process (GO:0070189)4.28304935
8regulation of female gonad development (GO:2000194)4.27175805
9protein polyglutamylation (GO:0018095)4.24640469
10behavioral response to nicotine (GO:0035095)4.24066765
11fusion of sperm to egg plasma membrane (GO:0007342)4.21880445
12NAD biosynthetic process (GO:0009435)4.20538952
13DNA deamination (GO:0045006)4.18030329
14multicellular organism reproduction (GO:0032504)4.08913307
15negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.98524168
16negative regulation of translation, ncRNA-mediated (GO:0040033)3.98524168
17regulation of translation, ncRNA-mediated (GO:0045974)3.98524168
18cellular ketone body metabolic process (GO:0046950)3.96911909
19regulation of sarcomere organization (GO:0060297)3.94899103
20response to pheromone (GO:0019236)3.91273256
21establishment of protein localization to Golgi (GO:0072600)3.86325777
22indolalkylamine metabolic process (GO:0006586)3.76254970
23cilium or flagellum-dependent cell motility (GO:0001539)3.74585107
24regulation of cilium movement (GO:0003352)3.63047113
25telomere maintenance via semi-conservative replication (GO:0032201)3.61570016
26tryptophan metabolic process (GO:0006568)3.57239454
27ketone body metabolic process (GO:1902224)3.46344102
28calcium ion-dependent exocytosis (GO:0017156)3.45178076
29epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.43616831
30fucose catabolic process (GO:0019317)3.42618847
31L-fucose metabolic process (GO:0042354)3.42618847
32L-fucose catabolic process (GO:0042355)3.42618847
33cellular biogenic amine catabolic process (GO:0042402)3.41033280
34amine catabolic process (GO:0009310)3.41033280
35detection of light stimulus involved in sensory perception (GO:0050962)3.34857651
36detection of light stimulus involved in visual perception (GO:0050908)3.34857651
37tRNA methylation (GO:0030488)3.32509369
38telomere maintenance via recombination (GO:0000722)3.30729402
39G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.27261898
40plasma membrane fusion (GO:0045026)3.27195429
41epithelial cilium movement (GO:0003351)3.26827158
42interferon-gamma production (GO:0032609)3.24913790
43telomere maintenance via telomere lengthening (GO:0010833)3.23646524
44DNA strand elongation (GO:0022616)3.18661541
45kinetochore organization (GO:0051383)3.18582541
46negative regulation of systemic arterial blood pressure (GO:0003085)3.17647999
47kinetochore assembly (GO:0051382)3.16539829
48protein targeting to Golgi (GO:0000042)3.15897828
49DNA strand elongation involved in DNA replication (GO:0006271)3.15793790
50DNA replication initiation (GO:0006270)3.15029978
51ribosomal small subunit assembly (GO:0000028)3.12889206
52pyridine nucleotide biosynthetic process (GO:0019363)3.12136252
53nicotinamide nucleotide biosynthetic process (GO:0019359)3.12136252
54maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.05209764
55spermatid development (GO:0007286)3.04209667
56mitotic recombination (GO:0006312)3.03824150
57reproduction (GO:0000003)3.02282933
58protein K48-linked deubiquitination (GO:0071108)3.00283585
59membrane depolarization during action potential (GO:0086010)2.98926301
60pseudouridine synthesis (GO:0001522)2.97791041
61cilium movement (GO:0003341)2.97676043
62ribosome biogenesis (GO:0042254)2.96716728
63musculoskeletal movement (GO:0050881)2.95930067
64multicellular organismal movement (GO:0050879)2.95930067
65retrograde transport, vesicle recycling within Golgi (GO:0000301)2.94862673
66meiotic chromosome segregation (GO:0045132)2.93934246
67response to misfolded protein (GO:0051788)2.92750137
68positive regulation of DNA-dependent DNA replication (GO:2000105)2.92628038
69rRNA modification (GO:0000154)2.91642065
70reflex (GO:0060004)2.90692184
71cAMP catabolic process (GO:0006198)2.89627131
72axonemal dynein complex assembly (GO:0070286)2.88903386
73regulation of microtubule-based movement (GO:0060632)2.87148372
74RNA destabilization (GO:0050779)2.82911464
75regulation of hippo signaling (GO:0035330)2.82244210
76alanine transport (GO:0032328)2.79744287
77sperm capacitation (GO:0048240)2.79260525
78protein K6-linked ubiquitination (GO:0085020)2.79089429
79nephron epithelium morphogenesis (GO:0072088)2.77703984
80nephron tubule morphogenesis (GO:0072078)2.77703984
81indole-containing compound metabolic process (GO:0042430)2.77421208
82peristalsis (GO:0030432)2.76639220
83tRNA modification (GO:0006400)2.75830526
84DNA replication checkpoint (GO:0000076)2.74706146
85mitotic metaphase plate congression (GO:0007080)2.74565230
86positive regulation of CREB transcription factor activity (GO:0032793)2.73601850
87ribonucleoprotein complex biogenesis (GO:0022613)2.72715184
88regulation of Rab GTPase activity (GO:0032313)2.72056189
89positive regulation of Rab GTPase activity (GO:0032851)2.72056189
90replication fork processing (GO:0031297)2.72044061
91telomere maintenance (GO:0000723)2.70816744
92termination of RNA polymerase III transcription (GO:0006386)2.69712815
93transcription elongation from RNA polymerase III promoter (GO:0006385)2.69712815
94telomere organization (GO:0032200)2.69587239
95CENP-A containing nucleosome assembly (GO:0034080)2.69240921
96negative regulation of telomere maintenance (GO:0032205)2.69106812
97ribosomal large subunit biogenesis (GO:0042273)2.67115682
98rRNA methylation (GO:0031167)2.66914619
99protein localization to Golgi apparatus (GO:0034067)2.66885908
100gamma-aminobutyric acid transport (GO:0015812)2.66748662
101negative regulation of DNA-dependent DNA replication (GO:2000104)2.66582370
102axoneme assembly (GO:0035082)2.66134910
103peptidyl-threonine dephosphorylation (GO:0035970)2.65188271
104positive regulation of gamma-delta T cell activation (GO:0046645)2.63990115
105chromatin remodeling at centromere (GO:0031055)2.63777644
106termination of RNA polymerase I transcription (GO:0006363)2.62748794
107nucleotide-excision repair, DNA gap filling (GO:0006297)2.62255801
108regulation of double-strand break repair via homologous recombination (GO:0010569)2.61941281
109rRNA processing (GO:0006364)2.61837726
110maturation of SSU-rRNA (GO:0030490)2.61708109
111motile cilium assembly (GO:0044458)2.61693554
112metaphase plate congression (GO:0051310)2.61163569
113cyclic nucleotide catabolic process (GO:0009214)2.61047779
114primary amino compound metabolic process (GO:1901160)2.60152565
115phosphatidylethanolamine biosynthetic process (GO:0006646)2.57920968
116organic cation transport (GO:0015695)2.57601518
117membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.57489826
118positive regulation of heat generation (GO:0031652)2.56537653
119limb development (GO:0060173)2.55994139
120appendage development (GO:0048736)2.55994139
121leukocyte aggregation (GO:0070486)2.55947023
122negative regulation of Rho protein signal transduction (GO:0035024)2.55662415
123somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.55267771
124somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.55267771
125isotype switching (GO:0045190)2.55267771
126rRNA metabolic process (GO:0016072)2.54669597
127protein K63-linked deubiquitination (GO:0070536)2.53739136
128transcription elongation from RNA polymerase I promoter (GO:0006362)2.53523990
129IMP biosynthetic process (GO:0006188)2.53511354
130endothelial cell chemotaxis (GO:0035767)2.52895167
131maturation of 5.8S rRNA (GO:0000460)2.51480737
132nonmotile primary cilium assembly (GO:0035058)2.50973324
133sperm-egg recognition (GO:0035036)2.49132173
134nuclear pore organization (GO:0006999)2.48408783
135detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.48168061
136cell wall macromolecule metabolic process (GO:0044036)2.48076926
137RNA methylation (GO:0001510)2.47107862
138phosphatidylethanolamine metabolic process (GO:0046337)2.47086989
139nuclear pore complex assembly (GO:0051292)2.46876796
140spinal cord motor neuron differentiation (GO:0021522)2.46446171
141DNA integration (GO:0015074)2.45917326
142regulation of transcription involved in cell fate commitment (GO:0060850)2.45454620
143cellular response to interleukin-15 (GO:0071350)2.45358721
144cilium organization (GO:0044782)2.44756632
145telomere maintenance via telomerase (GO:0007004)2.44362578
146mismatch repair (GO:0006298)2.44263436
147DNA synthesis involved in DNA repair (GO:0000731)2.44219880
148RNA-dependent DNA replication (GO:0006278)2.43681345
149single strand break repair (GO:0000012)2.43439745
150regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.43154399
151dendritic spine morphogenesis (GO:0060997)2.42784857
152cilium assembly (GO:0042384)2.42595148
153transcription-coupled nucleotide-excision repair (GO:0006283)2.42159926
154transcription from RNA polymerase I promoter (GO:0006360)2.41119536
155cellular response to ATP (GO:0071318)2.41012688
156deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.40938974
157regulation of telomere maintenance via telomerase (GO:0032210)2.40372550
158DNA strand renaturation (GO:0000733)2.40235471
159arginine catabolic process (GO:0006527)2.39894457
160regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.39416840
161somatic recombination of immunoglobulin gene segments (GO:0016447)2.39255474
162positive regulation of organelle assembly (GO:1902117)2.38861409
163antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.37651138
164establishment of chromosome localization (GO:0051303)2.36971170
165somatic diversification of immune receptors via somatic mutation (GO:0002566)2.36840579
166somatic hypermutation of immunoglobulin genes (GO:0016446)2.36840579
167DNA replication-independent nucleosome assembly (GO:0006336)2.36749958
168DNA replication-independent nucleosome organization (GO:0034724)2.36749958
169negative regulation of mast cell activation (GO:0033004)2.35894699
170ribosomal small subunit biogenesis (GO:0042274)2.34761642
171signal peptide processing (GO:0006465)2.34751715
172neuronal action potential (GO:0019228)2.34682980
173histone H4-K12 acetylation (GO:0043983)2.34416592
174regulation of helicase activity (GO:0051095)2.34262166
175positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.34207685
176regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.34207685
177microtubule severing (GO:0051013)2.34083281
178regulation of DNA-dependent DNA replication (GO:0090329)2.33863639
179regulation of B cell receptor signaling pathway (GO:0050855)2.33459177
180centriole assembly (GO:0098534)2.31749122
181superoxide anion generation (GO:0042554)2.31499445
182DNA-dependent DNA replication (GO:0006261)2.30799141
183ncRNA processing (GO:0034470)2.30698983
184exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.30233189
185nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.25979060
186DNA replication (GO:0006260)2.25696820
187tRNA processing (GO:0008033)2.25523616
188mitochondrial DNA replication (GO:0006264)2.24796479
189positive regulation of DNA recombination (GO:0045911)2.23883427
190DNA recombination (GO:0006310)2.22345695
191pore complex assembly (GO:0046931)2.21815019
192positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.21052459
193DNA-templated transcription, termination (GO:0006353)2.20994811
194negative regulation of phagocytosis (GO:0050765)2.20169715
195protein localization to kinetochore (GO:0034501)2.20126676
196positive regulation of isotype switching (GO:0045830)2.19640084
197regulation of DNA recombination (GO:0000018)2.19448511
198somatic cell DNA recombination (GO:0016444)2.19371679
199somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.19371679
200viral mRNA export from host cell nucleus (GO:0046784)2.19339088

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.31254484
2EZH2_22144423_ChIP-Seq_EOC_Human4.99408641
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.40819090
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.35949931
5NOTCH1_21737748_ChIP-Seq_TLL_Human3.12414053
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.87923704
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.71003105
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.61169808
9ZNF274_21170338_ChIP-Seq_K562_Hela2.59648632
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.58103710
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.56052513
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.51669099
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.50614668
14VDR_22108803_ChIP-Seq_LS180_Human2.49753219
15DROSHA_22980978_ChIP-Seq_HELA_Human2.45736866
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.44964235
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.38858499
18GBX2_23144817_ChIP-Seq_PC3_Human2.38547737
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.32639007
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.31283842
21EST1_17652178_ChIP-ChIP_JURKAT_Human2.31237237
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.29321965
23MYC_18358816_ChIP-ChIP_MESCs_Mouse2.29321829
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.28536587
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.19886109
26FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.12890499
27MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.12301503
28IRF8_21731497_ChIP-ChIP_J774_Mouse2.10758399
29* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.07198403
30ETS1_20019798_ChIP-Seq_JURKAT_Human2.01760943
31VDR_23849224_ChIP-Seq_CD4+_Human2.01294875
32TP63_19390658_ChIP-ChIP_HaCaT_Human1.98134375
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.96411362
34IRF8_22096565_ChIP-ChIP_GC-B_Human1.93048331
35FOXP3_21729870_ChIP-Seq_TREG_Human1.92091789
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.90896357
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90118872
38TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89924950
39POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.89924950
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89839881
41* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.84425219
42KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.83961432
43KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.83961432
44KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.83961432
45EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.80179838
46CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.79638048
47ELK1_19687146_ChIP-ChIP_HELA_Human1.79409276
48ZFP57_27257070_Chip-Seq_ESCs_Mouse1.79052143
49BP1_19119308_ChIP-ChIP_Hs578T_Human1.75934550
50HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.74206842
51HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.74173601
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.70785179
53SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.67698959
54STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.65516021
55STAT4_19710469_ChIP-ChIP_TH1__Mouse1.63975817
56NANOG_18555785_ChIP-Seq_MESCs_Mouse1.62979190
57SPI1_23547873_ChIP-Seq_NB4_Human1.62818387
58FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.61957710
59NELFA_20434984_ChIP-Seq_ESCs_Mouse1.61729360
60AR_21572438_ChIP-Seq_LNCaP_Human1.60649132
61EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.60140294
62E2F1_21310950_ChIP-Seq_MCF-7_Human1.57946027
63EED_16625203_ChIP-ChIP_MESCs_Mouse1.57149174
64DCP1A_22483619_ChIP-Seq_HELA_Human1.54345912
65E2F1_18555785_ChIP-Seq_MESCs_Mouse1.54064959
66P300_19829295_ChIP-Seq_ESCs_Human1.51816880
67* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.51764709
68SRF_21415370_ChIP-Seq_HL-1_Mouse1.51473248
69CBX2_27304074_Chip-Seq_ESCs_Mouse1.50643818
70STAT3_23295773_ChIP-Seq_U87_Human1.50034800
71JARID2_20075857_ChIP-Seq_MESCs_Mouse1.49552669
72TTF2_22483619_ChIP-Seq_HELA_Human1.49101652
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.48612679
74* REST_21632747_ChIP-Seq_MESCs_Mouse1.48407428
75ER_23166858_ChIP-Seq_MCF-7_Human1.45965757
76EGR1_19374776_ChIP-ChIP_THP-1_Human1.45641532
77SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.45079620
78YY1_21170310_ChIP-Seq_MESCs_Mouse1.43273768
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43244195
80CBP_20019798_ChIP-Seq_JUKART_Human1.43244195
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42545916
82EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.42531389
83EZH2_27294783_Chip-Seq_ESCs_Mouse1.41177862
84PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39765035
85AR_25329375_ChIP-Seq_VCAP_Human1.39487144
86* SMAD4_21799915_ChIP-Seq_A2780_Human1.38862627
87ERG_20887958_ChIP-Seq_HPC-7_Mouse1.38328440
88STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.37969562
89SUZ12_27294783_Chip-Seq_ESCs_Mouse1.37660098
90NR3C1_21868756_ChIP-Seq_MCF10A_Human1.37415221
91TCF4_23295773_ChIP-Seq_U87_Human1.36859198
92XRN2_22483619_ChIP-Seq_HELA_Human1.36702315
93PIAS1_25552417_ChIP-Seq_VCAP_Human1.36257920
94BCAT_22108803_ChIP-Seq_LS180_Human1.35614575
95AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.34473715
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33300317
97IRF1_19129219_ChIP-ChIP_H3396_Human1.32993993
98* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.32088376
99YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31887723
100SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.31097964
101SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30536394
102CIITA_25753668_ChIP-Seq_RAJI_Human1.30270996
103MYCN_18555785_ChIP-Seq_MESCs_Mouse1.30093459
104THAP11_20581084_ChIP-Seq_MESCs_Mouse1.30090563
105POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29956470
106EZH2_27304074_Chip-Seq_ESCs_Mouse1.29894910
107SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.28475262
108SMAD4_21741376_ChIP-Seq_EPCs_Human1.27977627
109KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.27020570
110JARID2_20064375_ChIP-Seq_MESCs_Mouse1.26864569
111* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.26139068
112GABP_19822575_ChIP-Seq_HepG2_Human1.25998307
113BMI1_23680149_ChIP-Seq_NPCS_Mouse1.25899790
114PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25693360
115IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.24799219
116ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.24782815
117ARNT_22903824_ChIP-Seq_MCF-7_Human1.24039400
118SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.23815935
119PRDM14_20953172_ChIP-Seq_ESCs_Human1.23393548
120SCL_19346495_ChIP-Seq_HPC-7_Human1.23113842
121TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.22986386
122SMAD3_21741376_ChIP-Seq_EPCs_Human1.21836938
123ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.20976609
124FLI1_27457419_Chip-Seq_LIVER_Mouse1.20825679
125MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.20589111
126* MYB_26560356_Chip-Seq_TH2_Human1.20277557
127CREB1_15753290_ChIP-ChIP_HEK293T_Human1.19874151
128BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18580162
129* MYB_26560356_Chip-Seq_TH1_Human1.18496668
130TAF15_26573619_Chip-Seq_HEK293_Human1.17528322
131RUNX2_22187159_ChIP-Seq_PCA_Human1.16369204
132SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.16237250
133TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15667667
134IKZF1_21737484_ChIP-ChIP_HCT116_Human1.15257793
135MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.14957888
136* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.14876080
137TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14076295
138SMAD3_21741376_ChIP-Seq_ESCs_Human1.13552643
139NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.13536441
140PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13058920
141SMAD4_21741376_ChIP-Seq_HESCs_Human1.12711578
142RNF2_27304074_Chip-Seq_ESCs_Mouse1.12603996
143SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.12163670
144CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.11146803
145ETV2_25802403_ChIP-Seq_MESCs_Mouse1.11072934
146ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.09779979
147MYC_22102868_ChIP-Seq_BL_Human1.09652058
148ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09019250
149SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.08544083
150* GATA3_21878914_ChIP-Seq_MCF-7_Human1.08459950
151POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.08009675
152KDM2B_26808549_Chip-Seq_REH_Human1.07807714
153MYC_18940864_ChIP-ChIP_HL60_Human1.07775164
154RXR_22108803_ChIP-Seq_LS180_Human1.07745114
155TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06538437
156MTF2_20144788_ChIP-Seq_MESCs_Mouse1.05984943
157AHR_22903824_ChIP-Seq_MCF-7_Human1.05287669
158FUS_26573619_Chip-Seq_HEK293_Human1.05101587
159* RUNX1_22412390_ChIP-Seq_EML_Mouse1.04820105
160MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.04440069
161ERA_21632823_ChIP-Seq_H3396_Human1.03622419
162POU3F2_20337985_ChIP-ChIP_501MEL_Human1.03505186
163TCF4_22108803_ChIP-Seq_LS180_Human1.03359182
164EZH2_18974828_ChIP-Seq_MESCs_Mouse1.01875556
165RNF2_18974828_ChIP-Seq_MESCs_Mouse1.01875556
166NANOG_19829295_ChIP-Seq_ESCs_Human1.01819543
167SOX2_19829295_ChIP-Seq_ESCs_Human1.01819543
168NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.01328525
169MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00810042
170OCT4_20526341_ChIP-Seq_ESCs_Human0.99781174
171CJUN_26792858_Chip-Seq_BT549_Human0.99576370
172MYC_19829295_ChIP-Seq_ESCs_Human0.99404891
173LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.98160796
174TFEB_21752829_ChIP-Seq_HELA_Human0.98047012
175RNF2_27304074_Chip-Seq_NSC_Mouse0.97741153
176TP53_16413492_ChIP-PET_HCT116_Human0.97143788
177EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.96355689
178SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95505837
179SOX2_21211035_ChIP-Seq_LN229_Gbm0.95328984
180PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94129875
181NFE2_27457419_Chip-Seq_LIVER_Mouse0.93390674
182VDR_24787735_ChIP-Seq_THP-1_Human0.93182894
183TP53_18474530_ChIP-ChIP_U2OS_Human0.92189626
184CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.91951691
185VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.91703323
186JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91636563
187RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91586895
188* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.91319233
189SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.90771804
190RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.90570391
191SALL1_21062744_ChIP-ChIP_HESCs_Human0.90496544
192SUZ12_27294783_Chip-Seq_NPCs_Mouse0.87620278
193* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.87464303
194SOX2_18555785_ChIP-Seq_MESCs_Mouse0.85951180
195E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.85399383
196LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.84493756
197NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.82654884

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization4.38161917
2MP0008057_abnormal_DNA_replication3.07308358
3MP0001501_abnormal_sleep_pattern3.06405208
4MP0008058_abnormal_DNA_repair3.05259012
5MP0003693_abnormal_embryo_hatching3.04955620
6MP0003111_abnormal_nucleus_morphology3.03219879
7MP0003646_muscle_fatigue2.90185859
8MP0003195_calcinosis2.87967051
9MP0002396_abnormal_hematopoietic_system2.85614949
10MP0010094_abnormal_chromosome_stability2.84975040
11MP0005377_hearing/vestibular/ear_phenot2.78154619
12MP0003878_abnormal_ear_physiology2.78154619
13MP0000569_abnormal_digit_pigmentation2.66072129
14MP0003763_abnormal_thymus_physiology2.53974246
15MP0005671_abnormal_response_to2.50249012
16MP0005167_abnormal_blood-brain_barrier2.40723059
17MP0001835_abnormal_antigen_presentation2.30714990
18MP0003077_abnormal_cell_cycle2.29450577
19MP0002735_abnormal_chemical_nociception2.21597653
20MP0009745_abnormal_behavioral_response2.21285240
21MP0008007_abnormal_cellular_replicative2.19246543
22MP0005551_abnormal_eye_electrophysiolog2.11816512
23MP0006292_abnormal_olfactory_placode2.10038823
24MP0005075_abnormal_melanosome_morpholog2.08092479
25MP0004957_abnormal_blastocyst_morpholog2.07976317
26MP0001485_abnormal_pinna_reflex2.06024991
27MP0004142_abnormal_muscle_tone2.05675965
28MP0000490_abnormal_crypts_of2.01863356
29MP0009046_muscle_twitch1.99891840
30MP0001188_hyperpigmentation1.98530125
31MP0009785_altered_susceptibility_to1.97844577
32MP0002733_abnormal_thermal_nociception1.96699570
33MP0001968_abnormal_touch/_nociception1.91364679
34MP0009333_abnormal_splenocyte_physiolog1.90878976
35MP0003136_yellow_coat_color1.87980778
36MP0003941_abnormal_skin_development1.87829222
37MP0001348_abnormal_lacrimal_gland1.87453662
38MP0004043_abnormal_pH_regulation1.84305055
39MP0001440_abnormal_grooming_behavior1.84105559
40MP0005174_abnormal_tail_pigmentation1.83924020
41MP0003786_premature_aging1.82579951
42MP0001970_abnormal_pain_threshold1.80795989
43MP0001800_abnormal_humoral_immune1.80087434
44MP0000015_abnormal_ear_pigmentation1.79758270
45MP0001486_abnormal_startle_reflex1.75774791
46MP0002148_abnormal_hypersensitivity_rea1.70155761
47MP0002398_abnormal_bone_marrow1.70111484
48MP0003698_abnormal_male_reproductive1.69939362
49MP0002572_abnormal_emotion/affect_behav1.67150365
50MP0002452_abnormal_antigen_presenting1.66079833
51MP0001790_abnormal_immune_system1.64717535
52MP0005387_immune_system_phenotype1.64717535
53MP0004742_abnormal_vestibular_system1.63794933
54MP0002132_abnormal_respiratory_system1.63558253
55MP0002420_abnormal_adaptive_immunity1.63184561
56MP0005000_abnormal_immune_tolerance1.63015834
57MP0001819_abnormal_immune_cell1.62205951
58MP0002723_abnormal_immune_serum1.62012452
59MP0002405_respiratory_system_inflammati1.60873720
60MP0003879_abnormal_hair_cell1.58172387
61MP0006276_abnormal_autonomic_nervous1.55561967
62MP0004381_abnormal_hair_follicle1.54878805
63MP0005025_abnormal_response_to1.52965665
64MP0002557_abnormal_social/conspecific_i1.52894631
65MP0005423_abnormal_somatic_nervous1.51261827
66MP0003724_increased_susceptibility_to1.50599641
67MP0000689_abnormal_spleen_morphology1.49816020
68MP0002722_abnormal_immune_system1.49229395
69MP0001905_abnormal_dopamine_level1.48502652
70MP0000685_abnormal_immune_system1.48071276
71MP0000703_abnormal_thymus_morphology1.47594279
72MP0002277_abnormal_respiratory_mucosa1.45246901
73MP0002272_abnormal_nervous_system1.44565958
74MP0008932_abnormal_embryonic_tissue1.44443635
75MP0000716_abnormal_immune_system1.43908882
76MP0000858_altered_metastatic_potential1.39708257
77MP0003436_decreased_susceptibility_to1.38310192
78MP0002067_abnormal_sensory_capabilities1.37071574
79MP0008875_abnormal_xenobiotic_pharmacok1.35428795
80MP0004885_abnormal_endolymph1.35161725
81MP0002419_abnormal_innate_immunity1.34089618
82MP0002138_abnormal_hepatobiliary_system1.33898215
83MP0003787_abnormal_imprinting1.32882158
84MP0000026_abnormal_inner_ear1.32334659
85MP0000465_gastrointestinal_hemorrhage1.32062340
86MP0002928_abnormal_bile_duct1.31798513
87MP0010386_abnormal_urinary_bladder1.31307172
88MP0000230_abnormal_systemic_arterial1.31134177
89MP0002064_seizures1.30828924
90MP0001545_abnormal_hematopoietic_system1.30453266
91MP0005397_hematopoietic_system_phenotyp1.30453266
92MP0002095_abnormal_skin_pigmentation1.29130168
93MP0002933_joint_inflammation1.28630818
94MP0008872_abnormal_physiological_respon1.28216872
95MP0002429_abnormal_blood_cell1.27025497
96MP0004808_abnormal_hematopoietic_stem1.26982575
97MP0001929_abnormal_gametogenesis1.26737757
98MP0001963_abnormal_hearing_physiology1.25712386
99MP0002653_abnormal_ependyma_morphology1.25067070
100MP0005253_abnormal_eye_physiology1.22517706
101MP0001853_heart_inflammation1.20460039
102MP0010155_abnormal_intestine_physiology1.20068059
103MP0002019_abnormal_tumor_incidence1.18242504
104MP0002822_catalepsy1.17764958
105MP0003448_altered_tumor_morphology1.15322554
106MP0003635_abnormal_synaptic_transmissio1.14724047
107MP0008877_abnormal_DNA_methylation1.14648954
108MP0008961_abnormal_basal_metabolism1.14584586
109MP0002736_abnormal_nociception_after1.12811723
110MP0002638_abnormal_pupillary_reflex1.12516110
111MP0000350_abnormal_cell_proliferation1.11486338
112MP0002734_abnormal_mechanical_nocicepti1.10374201
113MP0002006_tumorigenesis1.10196180
114MP0006082_CNS_inflammation1.10166014
115MP0010352_gastrointestinal_tract_polyps1.08958491
116MP0002063_abnormal_learning/memory/cond1.08829494
117MP0005171_absent_coat_pigmentation1.07346900
118MP0004133_heterotaxia1.06570912
119MP0002876_abnormal_thyroid_physiology1.03376722
120MP0002234_abnormal_pharynx_morphology1.02801131
121MP0005448_abnormal_energy_balance1.02387077
122MP0005595_abnormal_vascular_smooth1.01126457
123MP0004145_abnormal_muscle_electrophysio0.99435676
124MP0003950_abnormal_plasma_membrane0.99382267
125MP0004085_abnormal_heartbeat0.98464754
126MP0002229_neurodegeneration0.98038507
127MP0000313_abnormal_cell_death0.97240618
128MP0005310_abnormal_salivary_gland0.96350990
129MP0002837_dystrophic_cardiac_calcinosis0.94615460
130MP0000372_irregular_coat_pigmentation0.94221011
131MP0001986_abnormal_taste_sensitivity0.94083919
132MP0001873_stomach_inflammation0.93082779
133MP0000538_abnormal_urinary_bladder0.92888875
134MP0009278_abnormal_bone_marrow0.92035649
135MP0001186_pigmentation_phenotype0.91749599
136MP0008004_abnormal_stomach_pH0.91605949
137MP0005409_darkened_coat_color0.91380227
138MP0003045_fibrosis0.90770945
139MP0002168_other_aberrant_phenotype0.90360269
140MP0003633_abnormal_nervous_system0.90130368
141MP0001765_abnormal_ion_homeostasis0.89878651
142MP0002075_abnormal_coat/hair_pigmentati0.89855843
143MP0000566_synostosis0.89585737
144MP0010307_abnormal_tumor_latency0.89381942
145MP0004130_abnormal_muscle_cell0.88783528
146MP0005645_abnormal_hypothalamus_physiol0.88016567
147MP0005195_abnormal_posterior_eye0.86926934
148MP0000955_abnormal_spinal_cord0.85574973
149MP0005670_abnormal_white_adipose0.85228104
150MP0001845_abnormal_inflammatory_respons0.82778308
151MP0005464_abnormal_platelet_physiology0.82632811
152MP0003718_maternal_effect0.82495416
153MP0002752_abnormal_somatic_nervous0.82493096
154MP0000631_abnormal_neuroendocrine_gland0.82216664
155MP0005503_abnormal_tendon_morphology0.81712482
156MP0009379_abnormal_foot_pigmentation0.81391596
157MP0005084_abnormal_gallbladder_morpholo0.80990658
158MP0000371_diluted_coat_color0.80709094
159MP0001119_abnormal_female_reproductive0.79688782
160MP0004924_abnormal_behavior0.78685881
161MP0005386_behavior/neurological_phenoty0.78685881
162MP0000383_abnormal_hair_follicle0.78491039
163MP0004510_myositis0.77864275
164MP0005646_abnormal_pituitary_gland0.77755611
165MP0002254_reproductive_system_inflammat0.77156048
166MP0002166_altered_tumor_susceptibility0.76289266
167MP0000049_abnormal_middle_ear0.75968339
168MP0002161_abnormal_fertility/fecundity0.75563818
169MP0009115_abnormal_fat_cell0.75259887
170MP0002184_abnormal_innervation0.74959425
171MP0003137_abnormal_impulse_conducting0.74571536
172MP0006072_abnormal_retinal_apoptosis0.73936024
173MP0002938_white_spotting0.73539019
174MP0001293_anophthalmia0.72703560
175MP0002210_abnormal_sex_determination0.72160879
176MP0002102_abnormal_ear_morphology0.72099696
177MP0005389_reproductive_system_phenotype0.70825704
178MP0005535_abnormal_body_temperature0.70117984
179MP0001919_abnormal_reproductive_system0.70000708
180MP0010368_abnormal_lymphatic_system0.69504923
181MP0001542_abnormal_bone_strength0.67299091
182MP0000613_abnormal_salivary_gland0.66034570
183MP0005390_skeleton_phenotype0.65090358
184MP0003890_abnormal_embryonic-extraembry0.64831611
185MP0009764_decreased_sensitivity_to0.63635021
186MP0008260_abnormal_autophagy0.63565784
187MP0002160_abnormal_reproductive_system0.63201263
188MP0004947_skin_inflammation0.63002891
189MP0001286_abnormal_eye_development0.61281941
190MP0000470_abnormal_stomach_morphology0.60238302

Predicted human phenotypes

RankGene SetZ-score
1Genetic anticipation (HP:0003743)5.81618835
2Chromosomal breakage induced by crosslinking agents (HP:0003221)5.74517951
3Chromsome breakage (HP:0040012)5.44295148
4Progressive cerebellar ataxia (HP:0002073)5.20836248
5Duplicated collecting system (HP:0000081)4.34312090
6Nephronophthisis (HP:0000090)4.04769041
7Chronic hepatic failure (HP:0100626)3.97854254
8Pancreatic cysts (HP:0001737)3.97107177
9Abnormality of the renal collecting system (HP:0004742)3.90340549
10Attenuation of retinal blood vessels (HP:0007843)3.80430483
11Hyperventilation (HP:0002883)3.66913551
12Severe visual impairment (HP:0001141)3.64517843
13Absent/shortened dynein arms (HP:0200106)3.62384892
14Dynein arm defect of respiratory motile cilia (HP:0012255)3.62384892
15Molar tooth sign on MRI (HP:0002419)3.62145198
16Abnormality of midbrain morphology (HP:0002418)3.62145198
17True hermaphroditism (HP:0010459)3.57828446
18Pancreatic fibrosis (HP:0100732)3.57740562
19Abnormality of the renal medulla (HP:0100957)3.57596669
20Reticulocytopenia (HP:0001896)3.56294428
21Congenital stationary night blindness (HP:0007642)3.48664491
22Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.43989434
23Abnormality of the preputium (HP:0100587)3.41636561
24Meckel diverticulum (HP:0002245)3.36312160
25Decreased circulating renin level (HP:0003351)3.35582103
26Gaze-evoked nystagmus (HP:0000640)3.34844955
27Abnormality of the ileum (HP:0001549)3.30403338
28Tubular atrophy (HP:0000092)3.28700432
29Aplasia/Hypoplasia of the uvula (HP:0010293)3.27770675
30Hypoplastic ischia (HP:0003175)3.19307600
31Abnormal drinking behavior (HP:0030082)3.15324274
32Polydipsia (HP:0001959)3.15324274
33Bony spicule pigmentary retinopathy (HP:0007737)3.08950526
34Abnormality of chromosome stability (HP:0003220)3.02475480
35Cystic liver disease (HP:0006706)2.91329519
36Decreased central vision (HP:0007663)2.90669199
37Clubbing of toes (HP:0100760)2.89126933
38Abnormality of the renal cortex (HP:0011035)2.86707045
39Abnormality of DNA repair (HP:0003254)2.82493822
40Abnormal rod and cone electroretinograms (HP:0008323)2.81120916
41Increased corneal curvature (HP:0100692)2.76401386
42Keratoconus (HP:0000563)2.76401386
43Abolished electroretinogram (ERG) (HP:0000550)2.76162981
44Diplopia (HP:0000651)2.73131289
45Abnormality of binocular vision (HP:0011514)2.73131289
46Abnormal respiratory motile cilium morphology (HP:0005938)2.70993832
47Abnormal respiratory epithelium morphology (HP:0012253)2.70993832
48Sclerocornea (HP:0000647)2.70208492
49Retinal dysplasia (HP:0007973)2.68194419
50Abnormality of the ischium (HP:0003174)2.67368947
51Optic neuritis (HP:0100653)2.66016475
52Retrobulbar optic neuritis (HP:0100654)2.66016475
53Abnormal ciliary motility (HP:0012262)2.62138985
54Type II lissencephaly (HP:0007260)2.61941495
55Congenital sensorineural hearing impairment (HP:0008527)2.61182658
56Chronic mucocutaneous candidiasis (HP:0002728)2.59001573
57Recurrent cutaneous fungal infections (HP:0011370)2.59001573
58Absent thumb (HP:0009777)2.58612766
59Polyuria (HP:0000103)2.56898085
60Hyperkalemia (HP:0002153)2.55837174
61Myelodysplasia (HP:0002863)2.55519074
62Birth length less than 3rd percentile (HP:0003561)2.55435857
63Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.53419749
64Bone marrow hypocellularity (HP:0005528)2.53399032
65Clumsiness (HP:0002312)2.52882603
66Type I transferrin isoform profile (HP:0003642)2.52194021
67Myositis (HP:0100614)2.51323968
68Abnormality of the pubic bones (HP:0003172)2.50164274
69Duodenal stenosis (HP:0100867)2.49755484
70Small intestinal stenosis (HP:0012848)2.49755484
71IgG deficiency (HP:0004315)2.48336528
72Ectopic kidney (HP:0000086)2.48138909
73Intestinal atresia (HP:0011100)2.46923808
74Absent radius (HP:0003974)2.46141086
75IgM deficiency (HP:0002850)2.42519851
76Inability to walk (HP:0002540)2.41691907
77Protruding tongue (HP:0010808)2.41403035
78Abnormality of macular pigmentation (HP:0008002)2.37059914
79Premature graying of hair (HP:0002216)2.36368350
80Abnormal delayed hypersensitivity skin test (HP:0002963)2.35501163
81Orchitis (HP:0100796)2.33809420
82Congenital hepatic fibrosis (HP:0002612)2.33633463
83Stomatitis (HP:0010280)2.33302606
84Abnormal urine output (HP:0012590)2.32483283
85Panhypogammaglobulinemia (HP:0003139)2.32344983
86Bulbous nose (HP:0000414)2.31948167
87Decreased electroretinogram (ERG) amplitude (HP:0000654)2.29379758
88Aplasia involving forearm bones (HP:0009822)2.28704640
89Absent forearm bone (HP:0003953)2.28704640
90Lymphoma (HP:0002665)2.28335280
91Elevated erythrocyte sedimentation rate (HP:0003565)2.26687754
92Recurrent fungal infections (HP:0002841)2.26436284
93Type 2 muscle fiber atrophy (HP:0003554)2.25358007
94Aplastic anemia (HP:0001915)2.23472534
95Microvesicular hepatic steatosis (HP:0001414)2.22578637
96Potter facies (HP:0002009)2.22107485
97Facial shape deformation (HP:0011334)2.22107485
98Triphalangeal thumb (HP:0001199)2.21871256
99Prostate neoplasm (HP:0100787)2.20480572
100Nephroblastoma (Wilms tumor) (HP:0002667)2.20208520
101Increased IgM level (HP:0003496)2.19068492
102Chorioretinal atrophy (HP:0000533)2.19025332
103Recurrent abscess formation (HP:0002722)2.17724535
104Duplication of thumb phalanx (HP:0009942)2.17578871
105Abnormality of the duodenum (HP:0002246)2.15453594
106Abnormal respiratory motile cilium physiology (HP:0012261)2.15008426
107Medial flaring of the eyebrow (HP:0010747)2.12880776
108Tubulointerstitial abnormality (HP:0001969)2.12446491
109Upper limb muscle weakness (HP:0003484)2.12007806
110Rough bone trabeculation (HP:0100670)2.11596031
111Abnormality of the prostate (HP:0008775)2.11308567
112Abnormality of T cell physiology (HP:0011840)2.11084084
113Severe combined immunodeficiency (HP:0004430)2.10338652
114Abnormality of T cells (HP:0002843)2.08779051
115Cheilitis (HP:0100825)2.08005260
116Pendular nystagmus (HP:0012043)2.05726021
117Large for gestational age (HP:0001520)2.05591732
118Muscle fiber atrophy (HP:0100295)2.05377683
119Embryonal renal neoplasm (HP:0011794)2.04617536
120Increased neuronal autofluorescent lipopigment (HP:0002074)2.04235816
12111 pairs of ribs (HP:0000878)2.03703587
122Abnormality of the carotid arteries (HP:0005344)2.02560483
123Anencephaly (HP:0002323)2.02456177
124Cerebellar dysplasia (HP:0007033)2.01256154
125Tubulointerstitial nephritis (HP:0001970)2.00612275
126Short thumb (HP:0009778)2.00512037
127Abnormality of renal excretion (HP:0011036)2.00465928
128Chronic obstructive pulmonary disease (HP:0006510)2.00210420
129Obstructive lung disease (HP:0006536)2.00210420
130Petechiae (HP:0000967)1.99625831
131Eczematoid dermatitis (HP:0000976)1.99577250
132Patellar aplasia (HP:0006443)1.96811519
133Supernumerary spleens (HP:0009799)1.96385495
134Tracheoesophageal fistula (HP:0002575)1.95647959
135Encephalitis (HP:0002383)1.95360037
136Autoimmune thrombocytopenia (HP:0001973)1.95112706
137Tubulointerstitial fibrosis (HP:0005576)1.93496662
138Absent speech (HP:0001344)1.93325504
139Agnosia (HP:0010524)1.93041880
140Febrile seizures (HP:0002373)1.92989127
141T lymphocytopenia (HP:0005403)1.92603542
142Meningitis (HP:0001287)1.90998248
143Pallor (HP:0000980)1.90452551
144Pulmonary fibrosis (HP:0002206)1.90071916
145Impaired smooth pursuit (HP:0007772)1.89667267
146Abnormality of potassium homeostasis (HP:0011042)1.89312491
147Hemiparesis (HP:0001269)1.89084001
148Oral leukoplakia (HP:0002745)1.89002586
149Abnormal number of erythroid precursors (HP:0012131)1.88816602
150Aplasia/Hypoplasia of the tongue (HP:0010295)1.88295139
151Abnormality of renin-angiotensin system (HP:0000847)1.88273626
152Chronic diarrhea (HP:0002028)1.87461776
153Squamous cell carcinoma (HP:0002860)1.87346171
154Abnormality of T cell number (HP:0011839)1.87244683
155Aplasia/Hypoplasia of the tibia (HP:0005772)1.86379237
156Mesangial abnormality (HP:0001966)1.85842883
157Combined immunodeficiency (HP:0005387)1.84784739
158Occipital encephalocele (HP:0002085)1.83961864
159Broad-based gait (HP:0002136)1.83467209
160Pancytopenia (HP:0001876)1.82814862
161Oligodactyly (hands) (HP:0001180)1.82547293
162Ureteral duplication (HP:0000073)1.82015540
163Lissencephaly (HP:0001339)1.81914055
164Macular degeneration (HP:0000608)1.81250882
165Stage 5 chronic kidney disease (HP:0003774)1.81219009
166Asplenia (HP:0001746)1.79554435
167Portal hypertension (HP:0001409)1.78376505
168Aplasia/Hypoplasia of the patella (HP:0006498)1.77620181
169Aplasia/Hypoplasia of the lens (HP:0008063)1.77473237
170Amelogenesis imperfecta (HP:0000705)1.77057614
171Reduced antithrombin III activity (HP:0001976)1.77027292
172Horseshoe kidney (HP:0000085)1.76070150
173Recurrent viral infections (HP:0004429)1.75715304
174Abnormality of cells of the erythroid lineage (HP:0012130)1.75237298
175Leukopenia (HP:0001882)1.75058926
176Prolonged bleeding time (HP:0003010)1.74875182
177Sloping forehead (HP:0000340)1.74718543
178Widely spaced teeth (HP:0000687)1.73321091
179Bell-shaped thorax (HP:0001591)1.73043947
180Rib fusion (HP:0000902)1.72903008
181Abnormal biliary tract physiology (HP:0012439)1.72864318
182Bile duct proliferation (HP:0001408)1.72864318
183Male pseudohermaphroditism (HP:0000037)1.72520793
184Progressive inability to walk (HP:0002505)1.71975843
185Abnormal trabecular bone morphology (HP:0100671)1.71012705
186Narrow nasal bridge (HP:0000446)1.70340946
187Cone-rod dystrophy (HP:0000548)1.70311302
188Abnormality of eosinophils (HP:0001879)1.69778972
189Mediastinal lymphadenopathy (HP:0100721)1.69396254
190Aplasia/Hypoplasia of the fovea (HP:0008060)1.69124529
191Hypoplasia of the fovea (HP:0007750)1.69124529
192Granulocytopenia (HP:0001913)1.69100981
193Aplasia/Hypoplasia of the sacrum (HP:0008517)1.68900837
194Gait imbalance (HP:0002141)1.68344833
195Glomerulopathy (HP:0100820)1.67000932
196Genital tract atresia (HP:0001827)1.66729540
197Supernumerary bones of the axial skeleton (HP:0009144)1.65192311
198Pachygyria (HP:0001302)1.64065019
199Leukocytosis (HP:0001974)1.63434603

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.97772586
2ZAK3.36572222
3TXK3.35284475
4INSRR3.29076048
5BMPR1B3.11841502
6STK162.86246212
7BUB12.73323998
8DDR22.64766207
9SIK22.52938939
10IRAK32.45737374
11IRAK42.38263776
12EPHA22.24475587
13MKNK22.17080178
14WNK42.11065143
15MKNK12.04556444
16MAP4K12.03151852
17MAP4K22.01854209
18MAP3K142.01566335
19SRPK11.99511642
20CDK121.94942060
21CAMK1G1.92283737
22EIF2AK21.90239212
23MAPK151.86171008
24PNCK1.78867685
25NME21.76763385
26DAPK21.76729253
27WEE11.74125867
28JAK31.73181215
29TLK11.70262028
30CDC71.65322788
31PIM21.63452804
32TTK1.62517988
33CAMK1D1.61005616
34CDK71.58081497
35VRK11.57915795
36TAOK31.53394090
37TEC1.48520100
38ADRBK21.46521650
39WNK31.45207064
40PLK41.43066878
41IKBKB1.43050833
42BRD41.40494491
43STK381.39207214
44PTK2B1.39192563
45ATR1.35593143
46ADRBK11.35366950
47BTK1.33462751
48MAPK131.29843956
49BLK1.29454033
50EIF2AK31.27748088
51PIM11.26763190
52PLK11.25467797
53CHEK21.22530422
54ZAP701.21886621
55YES11.20366036
56TSSK61.18557705
57TGFBR11.17401597
58NTRK31.14763568
59TIE11.13855353
60STK101.13578350
61PINK11.12348502
62FLT31.09345838
63AURKB1.08364286
64SIK31.07855730
65PASK1.06965738
66TGFBR21.06144251
67ACVR1B1.03822550
68NLK1.02943491
69KIT1.01076101
70IKBKE1.00735445
71PRKCG1.00109888
72WNK11.00069817
73PRKCE0.98907696
74CLK10.95761971
75MAP3K40.95643558
76LCK0.94868758
77TESK20.93247177
78CHUK0.91414248
79LYN0.91006240
80NEK60.90566240
81KDR0.87702980
82RPS6KA60.87030434
83GRK10.85632108
84PKN10.85329046
85BRSK20.85103002
86CASK0.83500287
87PRKD30.83264032
88RPS6KB20.82972955
89IRAK10.81566297
90PLK20.81214154
91TYRO30.80454492
92OXSR10.79269215
93CSF1R0.77060445
94EIF2AK10.76645633
95PRKAA20.76263865
96ITK0.76017515
97PAK30.75508854
98TNIK0.75406005
99GRK70.75290128
100CAMK10.74485279
101HCK0.73992613
102RPS6KA40.73620439
103CHEK10.73395183
104CSK0.73067531
105NEK20.71596655
106STK390.71264234
107MAPK70.71072513
108CCNB10.69135138
109PLK30.67209258
110TAOK20.67070047
111PRKCH0.66338461
112CAMKK10.66274380
113CDK30.66231179
114CDK40.65982592
115TRPM70.65029632
116NUAK10.64748568
117ATM0.64313770
118CDC42BPA0.63346028
119IRAK20.62486751
120MAP3K70.62297448
121STK40.62276712
122RPS6KA50.61852822
123CAMKK20.60084514
124RPS6KA20.59749939
125DYRK30.59683091
126AKT30.57800705
127AURKA0.56992433
128PRPF4B0.56508219
129PRKAA10.56177875
130SYK0.55450519
131TYK20.52229563
132SGK2230.51141829
133SGK4940.51141829
134NTRK20.49837728
135CAMK40.49613813
136MARK10.48477621
137MST40.47993972
138CSNK2A10.47924007
139SGK20.47363638
140PRKG10.46451689
141DYRK20.46054464
142PRKCZ0.45417083
143STK38L0.45232969
144CDK20.44420998
145ERBB20.44115489
146FER0.43328465
147HIPK20.41848854
148TNK20.41194834
149PRKCI0.40719591
150RPS6KL10.40163790
151RPS6KC10.40163790
152PIK3CG0.39956146
153PIK3CA0.39852917
154STK110.39785190
155MAP3K80.38700165
156CSNK2A20.38690847
157MAP2K60.37753028
158CAMK2A0.37259842
159MAPKAPK30.37006645
160MAPK10.36681484
161MARK30.36119880
162CDK60.36038539
163PRKCA0.35645209
164ROCK10.35180216
165MATK0.35031861
166CDK80.34966451
167PRKACA0.34374818
168SGK10.33391086
169PDK10.31019698
170PRKCQ0.29298924
171PRKD20.28756588
172MARK20.28679573
173MAPK80.27319770

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.34593398
2Mismatch repair_Homo sapiens_hsa034303.19084631
3Homologous recombination_Homo sapiens_hsa034402.79781715
4Fanconi anemia pathway_Homo sapiens_hsa034602.78418382
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.77678897
6RNA polymerase_Homo sapiens_hsa030202.67176754
7Base excision repair_Homo sapiens_hsa034102.45365465
8Nicotine addiction_Homo sapiens_hsa050332.37086285
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.36829378
10Morphine addiction_Homo sapiens_hsa050322.31244821
11Primary immunodeficiency_Homo sapiens_hsa053402.27350438
12Ribosome_Homo sapiens_hsa030102.22732581
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.19169708
14Phototransduction_Homo sapiens_hsa047442.18432710
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.17576516
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.15266591
17Nucleotide excision repair_Homo sapiens_hsa034202.12350128
18Spliceosome_Homo sapiens_hsa030402.10977618
19Linoleic acid metabolism_Homo sapiens_hsa005912.08838816
20Butanoate metabolism_Homo sapiens_hsa006501.96702734
21Pyrimidine metabolism_Homo sapiens_hsa002401.95047668
22Selenocompound metabolism_Homo sapiens_hsa004501.90096245
23Taste transduction_Homo sapiens_hsa047421.87567084
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.83228291
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.80350537
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.80240447
27Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.77498859
28Non-homologous end-joining_Homo sapiens_hsa034501.76373222
29Caffeine metabolism_Homo sapiens_hsa002321.74688181
30Basal transcription factors_Homo sapiens_hsa030221.74489250
31GABAergic synapse_Homo sapiens_hsa047271.69996415
32p53 signaling pathway_Homo sapiens_hsa041151.67729966
33ABC transporters_Homo sapiens_hsa020101.67700959
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.64618846
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.64463645
36RNA transport_Homo sapiens_hsa030131.64329994
37Tryptophan metabolism_Homo sapiens_hsa003801.63257768
38Fatty acid biosynthesis_Homo sapiens_hsa000611.62261007
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.62225789
40Olfactory transduction_Homo sapiens_hsa047401.61040589
41Cell cycle_Homo sapiens_hsa041101.60869270
42Allograft rejection_Homo sapiens_hsa053301.60449493
43One carbon pool by folate_Homo sapiens_hsa006701.58986186
44Circadian entrainment_Homo sapiens_hsa047131.56829844
45Intestinal immune network for IgA production_Homo sapiens_hsa046721.56711756
46Glutamatergic synapse_Homo sapiens_hsa047241.55949967
47Serotonergic synapse_Homo sapiens_hsa047261.55935516
48Nitrogen metabolism_Homo sapiens_hsa009101.55647963
49Graft-versus-host disease_Homo sapiens_hsa053321.52864826
50Proteasome_Homo sapiens_hsa030501.50001837
51Ether lipid metabolism_Homo sapiens_hsa005651.46850850
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.46041023
53RNA degradation_Homo sapiens_hsa030181.44377576
54Maturity onset diabetes of the young_Homo sapiens_hsa049501.41708578
55Measles_Homo sapiens_hsa051621.40908508
56Hematopoietic cell lineage_Homo sapiens_hsa046401.40658222
57Insulin secretion_Homo sapiens_hsa049111.40599430
58Herpes simplex infection_Homo sapiens_hsa051681.37540432
59Dorso-ventral axis formation_Homo sapiens_hsa043201.36445208
60Primary bile acid biosynthesis_Homo sapiens_hsa001201.32429166
61Autoimmune thyroid disease_Homo sapiens_hsa053201.29236948
62Calcium signaling pathway_Homo sapiens_hsa040201.24357522
63Vascular smooth muscle contraction_Homo sapiens_hsa042701.24211251
64RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.20023834
65Type II diabetes mellitus_Homo sapiens_hsa049301.14542438
66Purine metabolism_Homo sapiens_hsa002301.11553704
67Cholinergic synapse_Homo sapiens_hsa047251.10684150
68Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.09213334
69Leishmaniasis_Homo sapiens_hsa051401.07447563
70Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.05843895
71Other glycan degradation_Homo sapiens_hsa005111.05063026
72Epstein-Barr virus infection_Homo sapiens_hsa051691.04976295
73Antigen processing and presentation_Homo sapiens_hsa046121.04793538
74mRNA surveillance pathway_Homo sapiens_hsa030151.04527544
75Salivary secretion_Homo sapiens_hsa049701.03384825
76NOD-like receptor signaling pathway_Homo sapiens_hsa046211.01639791
77Asthma_Homo sapiens_hsa053101.00397672
78Protein export_Homo sapiens_hsa030600.97059930
79Ovarian steroidogenesis_Homo sapiens_hsa049130.95253739
80Oxytocin signaling pathway_Homo sapiens_hsa049210.94707561
81T cell receptor signaling pathway_Homo sapiens_hsa046600.94609620
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.94370498
83Cocaine addiction_Homo sapiens_hsa050300.93756357
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.93688495
85Aldosterone synthesis and secretion_Homo sapiens_hsa049250.92245810
86Gastric acid secretion_Homo sapiens_hsa049710.92076918
87Jak-STAT signaling pathway_Homo sapiens_hsa046300.90629775
88Glycerolipid metabolism_Homo sapiens_hsa005610.90511461
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.87277977
90cAMP signaling pathway_Homo sapiens_hsa040240.86650527
91Apoptosis_Homo sapiens_hsa042100.85622014
92Lysine degradation_Homo sapiens_hsa003100.85575242
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83829952
94Malaria_Homo sapiens_hsa051440.80873107
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.80865129
96HTLV-I infection_Homo sapiens_hsa051660.79688970
97Arachidonic acid metabolism_Homo sapiens_hsa005900.78865091
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75311793
99Toll-like receptor signaling pathway_Homo sapiens_hsa046200.74761691
100Dopaminergic synapse_Homo sapiens_hsa047280.74734449
101Chemical carcinogenesis_Homo sapiens_hsa052040.73818899
102Viral carcinogenesis_Homo sapiens_hsa052030.73744223
103Legionellosis_Homo sapiens_hsa051340.71101283
104Hepatitis B_Homo sapiens_hsa051610.70442079
105B cell receptor signaling pathway_Homo sapiens_hsa046620.69121654
106Retinol metabolism_Homo sapiens_hsa008300.68490876
107Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.64425499
108TNF signaling pathway_Homo sapiens_hsa046680.63590382
109Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63268904
110Influenza A_Homo sapiens_hsa051640.62825039
111Systemic lupus erythematosus_Homo sapiens_hsa053220.61030176
112Osteoclast differentiation_Homo sapiens_hsa043800.60553405
113Notch signaling pathway_Homo sapiens_hsa043300.60441733
114Folate biosynthesis_Homo sapiens_hsa007900.58643795
115Shigellosis_Homo sapiens_hsa051310.58609388
116Type I diabetes mellitus_Homo sapiens_hsa049400.58535498
117Acute myeloid leukemia_Homo sapiens_hsa052210.58404931
118MAPK signaling pathway_Homo sapiens_hsa040100.58005861
119Small cell lung cancer_Homo sapiens_hsa052220.57140404
120Glycosaminoglycan degradation_Homo sapiens_hsa005310.56960277
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56558561
122African trypanosomiasis_Homo sapiens_hsa051430.51831274
123Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.51712327
124MicroRNAs in cancer_Homo sapiens_hsa052060.50932215
125Mineral absorption_Homo sapiens_hsa049780.50243936
126Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49690016
127Sphingolipid metabolism_Homo sapiens_hsa006000.49367200
128Hedgehog signaling pathway_Homo sapiens_hsa043400.48984370
129Adipocytokine signaling pathway_Homo sapiens_hsa049200.48963906
130Rheumatoid arthritis_Homo sapiens_hsa053230.48319244
131PPAR signaling pathway_Homo sapiens_hsa033200.47157201
132Renin secretion_Homo sapiens_hsa049240.45618870
133Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44215209
134Long-term depression_Homo sapiens_hsa047300.44006715
135cGMP-PKG signaling pathway_Homo sapiens_hsa040220.43571202
136Viral myocarditis_Homo sapiens_hsa054160.43045167
137Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42412837
138Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.42354378
139Tuberculosis_Homo sapiens_hsa051520.42265478
140Regulation of autophagy_Homo sapiens_hsa041400.42111439
141Circadian rhythm_Homo sapiens_hsa047100.41573330
142Lysosome_Homo sapiens_hsa041420.41137076
143Pertussis_Homo sapiens_hsa051330.41134855
144TGF-beta signaling pathway_Homo sapiens_hsa043500.40369191
145Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.40005484
146Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39620393
147Toxoplasmosis_Homo sapiens_hsa051450.39597677
148Staphylococcus aureus infection_Homo sapiens_hsa051500.39359530
149Basal cell carcinoma_Homo sapiens_hsa052170.39061173
150Pathways in cancer_Homo sapiens_hsa052000.38460372
151Chemokine signaling pathway_Homo sapiens_hsa040620.36514836
152Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.35502223
153Vitamin B6 metabolism_Homo sapiens_hsa007500.35364212
154Protein digestion and absorption_Homo sapiens_hsa049740.34926274
155Phospholipase D signaling pathway_Homo sapiens_hsa040720.34915990
156Fat digestion and absorption_Homo sapiens_hsa049750.34745797
157Ras signaling pathway_Homo sapiens_hsa040140.34341376
158Estrogen signaling pathway_Homo sapiens_hsa049150.33507282
159Bile secretion_Homo sapiens_hsa049760.33431673
160Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32943858
161Complement and coagulation cascades_Homo sapiens_hsa046100.32074741
162Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.31757760
163Leukocyte transendothelial migration_Homo sapiens_hsa046700.31693631
164Peroxisome_Homo sapiens_hsa041460.31684802
165Platelet activation_Homo sapiens_hsa046110.31408397
166Wnt signaling pathway_Homo sapiens_hsa043100.30420545
167Insulin resistance_Homo sapiens_hsa049310.30293023
168Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.30237124
169Colorectal cancer_Homo sapiens_hsa052100.29348132
170Hepatitis C_Homo sapiens_hsa051600.29055913
171N-Glycan biosynthesis_Homo sapiens_hsa005100.28815105
172Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.28740053
173Sulfur relay system_Homo sapiens_hsa041220.28307363
174PI3K-Akt signaling pathway_Homo sapiens_hsa041510.27872712
175Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.27694746
176SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27634021

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