BTBD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The C-terminus of the protein encoded by this gene binds topoisomerase I. The N-terminus contains a proline-rich region and a BTB/POZ domain (broad-complex, Tramtrack and bric a brac/Pox virus and Zinc finger), both of which are typically involved in protein-protein interactions. Subcellularly, the protein localizes to cytoplasmic bodies. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nodal signaling pathway (GO:0038092)6.40908417
2pre-miRNA processing (GO:0031054)5.41352834
3negative regulation of erythrocyte differentiation (GO:0045647)4.28609996
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.10782073
5synaptic vesicle maturation (GO:0016188)4.09944169
6locomotory exploration behavior (GO:0035641)4.08322419
7cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.88639333
8layer formation in cerebral cortex (GO:0021819)3.83152736
9histone H2A monoubiquitination (GO:0035518)3.75886050
10establishment of apical/basal cell polarity (GO:0035089)3.74339706
11neuromuscular process controlling posture (GO:0050884)3.71302047
12regulation of gene silencing by RNA (GO:0060966)3.71087231
13regulation of posttranscriptional gene silencing (GO:0060147)3.71087231
14regulation of gene silencing by miRNA (GO:0060964)3.71087231
15polarized epithelial cell differentiation (GO:0030859)3.67240287
16establishment of monopolar cell polarity (GO:0061162)3.63568026
17establishment or maintenance of monopolar cell polarity (GO:0061339)3.63568026
18cell communication by electrical coupling (GO:0010644)3.61680972
19activation of protein kinase A activity (GO:0034199)3.60139844
20regulation of short-term neuronal synaptic plasticity (GO:0048172)3.55872355
21cell migration in hindbrain (GO:0021535)3.55174090
22regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.52661816
23glutamate secretion (GO:0014047)3.50501682
24positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.47156480
25artery development (GO:0060840)3.39941796
26regulation of synapse structural plasticity (GO:0051823)3.39921775
27regulation of early endosome to late endosome transport (GO:2000641)3.39389654
28synaptic vesicle docking involved in exocytosis (GO:0016081)3.35542765
29negative regulation of cell size (GO:0045792)3.34517330
30mannose metabolic process (GO:0006013)3.33644925
31paraxial mesoderm development (GO:0048339)3.30805069
32protein retention in ER lumen (GO:0006621)3.27166396
33cerebellar granule cell differentiation (GO:0021707)3.23793361
34cell communication involved in cardiac conduction (GO:0086065)3.23553172
35apoptotic process involved in morphogenesis (GO:0060561)3.20123809
36regulation of mammary gland epithelial cell proliferation (GO:0033599)3.19250917
37exploration behavior (GO:0035640)3.18758209
38establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)3.17301525
39respiratory system process (GO:0003016)3.16977620
40cell-cell junction maintenance (GO:0045217)3.16492532
41regulation of ARF GTPase activity (GO:0032312)3.16178367
42peptidyl-lysine dimethylation (GO:0018027)3.15865183
43activation of Rac GTPase activity (GO:0032863)3.13893337
44semaphorin-plexin signaling pathway (GO:0071526)3.12464629
45protein targeting to plasma membrane (GO:0072661)3.10909544
46signal complex assembly (GO:0007172)3.10069908
47peptidyl-tyrosine autophosphorylation (GO:0038083)3.09941515
48cerebellar Purkinje cell layer development (GO:0021680)3.09740064
49regulation of hippo signaling (GO:0035330)3.06882012
50sodium ion export (GO:0071436)3.03742976
51negative regulation of microtubule polymerization (GO:0031115)3.00818738
52prepulse inhibition (GO:0060134)3.00772467
53proline transport (GO:0015824)3.00523874
54cytoskeletal anchoring at plasma membrane (GO:0007016)2.99785946
55response to pheromone (GO:0019236)2.98157787
56vocalization behavior (GO:0071625)2.95787430
57positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.95074444
58synaptic vesicle exocytosis (GO:0016079)2.94408872
59plasma membrane repair (GO:0001778)2.94005235
60positive regulation of synaptic transmission, GABAergic (GO:0032230)2.92563131
61regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.91682000
62maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.86622788
63peptidyl-arginine omega-N-methylation (GO:0035247)2.86402736
64regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.85336498
65activin receptor signaling pathway (GO:0032924)2.83792786
66neuromuscular process controlling balance (GO:0050885)2.83166100
67positive regulation of synapse maturation (GO:0090129)2.81682050
68protein localization to endosome (GO:0036010)2.81618490
69negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.81150793
70metanephric mesenchyme development (GO:0072075)2.80086491
71activation of MAPKKK activity (GO:0000185)2.77737989
72histone arginine methylation (GO:0034969)2.77003509
73histone H2A ubiquitination (GO:0033522)2.76766816
74neurotransmitter secretion (GO:0007269)2.75276368
75positive regulation of protein dephosphorylation (GO:0035307)2.75109452
76negative regulation of potassium ion transmembrane transport (GO:1901380)2.74851926
77regulation of glucose import in response to insulin stimulus (GO:2001273)2.74674547
78regulation of glutamate receptor signaling pathway (GO:1900449)2.72836119
79cell-substrate junction assembly (GO:0007044)2.71196505
80positive regulation of histone deacetylation (GO:0031065)2.69826348
81barbed-end actin filament capping (GO:0051016)2.67052594
82stress fiber assembly (GO:0043149)2.66380296
83activation of JUN kinase activity (GO:0007257)2.66294021
84negative regulation of myotube differentiation (GO:0010832)2.66280534
85regulation of NFAT protein import into nucleus (GO:0051532)2.64496957
86modulation by virus of host process (GO:0019054)2.64024455
87regulation of extracellular matrix disassembly (GO:0010715)2.63641913
88intracellular estrogen receptor signaling pathway (GO:0030520)2.63155522
89regulation of synaptic vesicle exocytosis (GO:2000300)2.62852360
90establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.62368903
91mitochondrion transport along microtubule (GO:0047497)2.62368903
92cardiac myofibril assembly (GO:0055003)2.61815659
93negative regulation of glial cell proliferation (GO:0060253)2.61764076
94dendritic spine morphogenesis (GO:0060997)2.61724807
95regulation of synapse maturation (GO:0090128)2.61160424
96negative regulation of catenin import into nucleus (GO:0035414)2.60721925
97mitotic G1 DNA damage checkpoint (GO:0031571)2.58867171
98negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.56846863
99kidney mesenchyme development (GO:0072074)2.56522771
100amino acid import (GO:0043090)2.54119254
101positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.53694216
102peptidyl-arginine N-methylation (GO:0035246)2.52288995
103peptidyl-arginine methylation (GO:0018216)2.52288995
104retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.51928228
105convergent extension (GO:0060026)2.51713904
106regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.49635935
107basement membrane organization (GO:0071711)2.48749158
108positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.48394107
109cellular potassium ion homeostasis (GO:0030007)2.47804457
110maternal placenta development (GO:0001893)2.46875844
111modulation by symbiont of host cellular process (GO:0044068)2.46829501
112adherens junction assembly (GO:0034333)2.46115307
113L-amino acid import (GO:0043092)2.45011732
114planar cell polarity pathway involved in neural tube closure (GO:0090179)2.44228824
115negative regulation of sodium ion transport (GO:0010766)2.44016565
116dopamine receptor signaling pathway (GO:0007212)2.42107938
117regulation of neuronal synaptic plasticity (GO:0048168)2.41174422
118negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.40977648
119positive regulation of receptor recycling (GO:0001921)2.40566690
120G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.40519411
121regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.40404315
1223-UTR-mediated mRNA stabilization (GO:0070935)2.39370290
123proline biosynthetic process (GO:0006561)2.39056836
124heterochromatin organization (GO:0070828)2.38497842
125neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.38322147
126left/right pattern formation (GO:0060972)2.38012259
127regulation of synaptic vesicle transport (GO:1902803)2.35420632
128positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.35406392
129glycine transport (GO:0015816)2.34745977
130regulation of chromatin binding (GO:0035561)2.33084346
131negative regulation of fatty acid transport (GO:2000192)2.33056148
132modulation by virus of host morphology or physiology (GO:0019048)2.32481554
133body morphogenesis (GO:0010171)2.31994226
134positive thymic T cell selection (GO:0045059)2.31294231
135neural tube development (GO:0021915)2.30189799
136regulation of translational fidelity (GO:0006450)2.29319572
137response to parathyroid hormone (GO:0071107)2.28384323
138thymic T cell selection (GO:0045061)2.28276207
139cell volume homeostasis (GO:0006884)2.28261651
140positive regulation of vesicle fusion (GO:0031340)2.28029152
141positive regulation of neurotransmitter secretion (GO:0001956)2.27884345
142vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.27859226
143positive regulation of blood vessel endothelial cell migration (GO:0043536)2.27237582
144Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.27016830
145regulation of ARF protein signal transduction (GO:0032012)2.26922202
146adenosine receptor signaling pathway (GO:0001973)2.26820925
147positive regulation of neurotransmitter transport (GO:0051590)2.26562534
148positive regulation of Rap GTPase activity (GO:0032854)2.25974696
149focal adhesion assembly (GO:0048041)2.25440915
150cell-substrate adherens junction assembly (GO:0007045)2.25440915
151positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.25321125
152cell migration involved in gastrulation (GO:0042074)2.25188209
153anatomical structure maturation (GO:0071695)2.24635458
154embryonic foregut morphogenesis (GO:0048617)2.24048396
155membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.22955249
156cell junction maintenance (GO:0034331)2.22081807
157negative regulation of telomerase activity (GO:0051974)2.21028916
158anatomical structure regression (GO:0060033)2.20853070
159response to water (GO:0009415)2.20637818
160epithelial cell differentiation involved in prostate gland development (GO:0060742)2.20440308
161osteoblast development (GO:0002076)2.18731239
162cortical actin cytoskeleton organization (GO:0030866)2.18133768
163neuronal ion channel clustering (GO:0045161)2.17929937
164response to laminar fluid shear stress (GO:0034616)2.17822151
165apoptotic process involved in development (GO:1902742)2.17578640
166cellular response to catecholamine stimulus (GO:0071870)2.17400987
167cellular response to monoamine stimulus (GO:0071868)2.17400987
168histone H4 deacetylation (GO:0070933)2.17240090
169protein-DNA complex disassembly (GO:0032986)2.16853351

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.11688310
2ZFP281_18757296_ChIP-ChIP_E14_Mouse3.11069205
3EZH2_22144423_ChIP-Seq_EOC_Human3.05043475
4ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.82813418
5SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.38950602
6ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.37731255
7ERG_21242973_ChIP-ChIP_JURKAT_Human2.37568121
8LXR_22292898_ChIP-Seq_THP-1_Human2.37418902
9KDM2B_26808549_Chip-Seq_SUP-B15_Human2.30954726
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.29498878
11MYC_22102868_ChIP-Seq_BL_Human2.24947450
12ZFP281_27345836_Chip-Seq_ESCs_Mouse2.20225423
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.14318936
14STAT6_21828071_ChIP-Seq_BEAS2B_Human2.09127774
15KDM2B_26808549_Chip-Seq_K562_Human2.03386516
16* RARB_27405468_Chip-Seq_BRAIN_Mouse1.97038971
17KDM2B_26808549_Chip-Seq_DND41_Human1.95007553
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.94545455
19ZNF263_19887448_ChIP-Seq_K562_Human1.94312612
20POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.93348873
21DNAJC2_21179169_ChIP-ChIP_NT2_Human1.92785345
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.92578862
23PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.92027128
24* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.89716723
25ESR1_15608294_ChIP-ChIP_MCF-7_Human1.88658949
26SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.85695305
27WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.84085798
28NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.83925072
29NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.78576210
30RACK7_27058665_Chip-Seq_MCF-7_Human1.71808590
31ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.71510406
32ELK3_25401928_ChIP-Seq_HUVEC_Human1.66794754
33KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.65393879
34ESR2_21235772_ChIP-Seq_MCF-7_Human1.65032758
35DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.64440065
36NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.63982523
37CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.63968577
38THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.61788080
39CTCF_27219007_Chip-Seq_Bcells_Human1.61483284
40TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.60821036
41* P68_20966046_ChIP-Seq_HELA_Human1.59971407
42SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.59711820
43EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.59042336
44TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.56756131
45KDM2B_26808549_Chip-Seq_JURKAT_Human1.53038737
46KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.51212016
47UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.51080407
48CREB1_26743006_Chip-Seq_LNCaP_Human1.50822739
49REST_18959480_ChIP-ChIP_MESCs_Mouse1.50319927
50VDR_24763502_ChIP-Seq_THP-1_Human1.49301674
51DROSHA_22980978_ChIP-Seq_HELA_Human1.49024636
52* TCF7_22412390_ChIP-Seq_EML_Mouse1.44506710
53SA1_27219007_Chip-Seq_ERYTHROID_Human1.44172367
54IKZF1_21737484_ChIP-ChIP_HCT116_Human1.43550403
55TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42213112
56RNF2_18974828_ChIP-Seq_MESCs_Mouse1.41788618
57EZH2_18974828_ChIP-Seq_MESCs_Mouse1.41788618
58RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.40640833
59SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.39418407
60RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.39147490
61NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.38989025
62CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.37130403
63VDR_21846776_ChIP-Seq_THP-1_Human1.36797461
64RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.34699898
65* TET1_21451524_ChIP-Seq_MESCs_Mouse1.33437636
66KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.33166324
67NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.33011139
68* ELF1_20517297_ChIP-Seq_JURKAT_Human1.32780993
69CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.30369455
70GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28274039
71MAF_26560356_Chip-Seq_TH2_Human1.27549406
72E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.27409841
73* SMC4_20622854_ChIP-Seq_HELA_Human1.26513353
74MAF_26560356_Chip-Seq_TH1_Human1.25315949
75MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.24726285
76P300_27058665_Chip-Seq_ZR-75-30cells_Human1.23411936
77JARID2_20064375_ChIP-Seq_MESCs_Mouse1.22711211
78* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.22554458
79JARID2_20075857_ChIP-Seq_MESCs_Mouse1.22301617
80REST_21632747_ChIP-Seq_MESCs_Mouse1.22193800
81POU5F1_16518401_ChIP-PET_MESCs_Mouse1.20319032
82SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.19442400
83SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.19072531
84NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.18975571
85UTX_26944678_Chip-Seq_JUKART_Human1.18843224
86TP53_22127205_ChIP-Seq_IMR90_Human1.18664265
87KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.18277367
88DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17817130
89* OCT4_19829295_ChIP-Seq_ESCs_Human1.17338544
90RING1B_27294783_Chip-Seq_ESCs_Mouse1.15795943
91EZH2_27294783_Chip-Seq_ESCs_Mouse1.14117753
92NANOG_21062744_ChIP-ChIP_HESCs_Human1.14036105
93ATF3_27146783_Chip-Seq_COLON_Human1.12598201
94* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.11649039
95* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.11339053
96TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.10582888
97KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10493284
98ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.09972137
99CLOCK_20551151_ChIP-Seq_293T_Human1.09777751
100TP53_20018659_ChIP-ChIP_R1E_Mouse1.09584768
101MTF2_20144788_ChIP-Seq_MESCs_Mouse1.09388318
102BCL6_27268052_Chip-Seq_Bcells_Human1.09373609
103GATA1_19941827_ChIP-Seq_MEL_Mouse1.09176446
104TET1_21490601_ChIP-Seq_MESCs_Mouse1.09070372
105KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08966773
106SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.07858568
107SUZ12_27294783_Chip-Seq_ESCs_Mouse1.07798702
108SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.07081257
109EGR1_19374776_ChIP-ChIP_THP-1_Human1.05792076
110CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.05177928
111VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04996603
112NCOR1_26117541_ChIP-Seq_K562_Human1.04868290
113SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.03949744
114* RUNX1_22412390_ChIP-Seq_EML_Mouse1.03847691
115RNF2_27304074_Chip-Seq_ESCs_Mouse1.03600961
116* TP63_22573176_ChIP-Seq_HFKS_Human1.03458153
117STAT3_1855785_ChIP-Seq_MESCs_Mouse1.03238255
118TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03015331
119BCOR_27268052_Chip-Seq_Bcells_Human1.02751406
120SRY_22984422_ChIP-ChIP_TESTIS_Rat1.02515838
121SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02400781
122GATA1_26923725_Chip-Seq_HPCs_Mouse1.02197932
123TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02143127
124PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.01937684
125* RUNX1_27514584_Chip-Seq_MCF-7_Human1.01900436
126RARG_19884340_ChIP-ChIP_MEFs_Mouse1.01793414
127FOXM1_23109430_ChIP-Seq_U2OS_Human1.01277140
128FOXP1_21924763_ChIP-Seq_HESCs_Human1.01058223
129SA1_27219007_Chip-Seq_Bcells_Human0.98803102
130CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.98566737
131RARA_24833708_ChIP-Seq_LIVER_Mouse0.98469319
132SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.98423158
133STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.96597606

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003283_abnormal_digestive_organ7.02204586
2MP0004859_abnormal_synaptic_plasticity3.95605060
3MP0004133_heterotaxia3.39914574
4MP0003123_paternal_imprinting2.68293348
5MP0005409_darkened_coat_color2.63157528
6MP0003635_abnormal_synaptic_transmissio2.36791399
7MP0000751_myopathy2.29012947
8MP0004270_analgesia2.25973810
9MP0003705_abnormal_hypodermis_morpholog2.20289757
10MP0008438_abnormal_cutaneous_collagen2.20025512
11MP0004858_abnormal_nervous_system2.19269064
12MP0009278_abnormal_bone_marrow2.18382539
13MP0010030_abnormal_orbit_morphology2.16320343
14MP0003329_amyloid_beta_deposits2.14189030
15MP0002822_catalepsy2.11571113
16MP0002837_dystrophic_cardiac_calcinosis2.06793352
17MP0004510_myositis2.06050060
18MP0005058_abnormal_lysosome_morphology2.02456896
19MP0003122_maternal_imprinting2.02152398
20MP0002653_abnormal_ependyma_morphology1.99597491
21MP0001849_ear_inflammation1.97377920
22MP0003172_abnormal_lysosome_physiology1.92331024
23MP0003279_aneurysm1.87571417
24MP0001958_emphysema1.85027624
25MP0003941_abnormal_skin_development1.83174435
26MP0002733_abnormal_thermal_nociception1.78081415
27MP0002063_abnormal_learning/memory/cond1.77681745
28MP0005451_abnormal_body_composition1.76917550
29MP0008260_abnormal_autophagy1.73618776
30MP0003303_peritoneal_inflammation1.73203094
31MP0000534_abnormal_ureter_morphology1.69473267
32MP0000537_abnormal_urethra_morphology1.63941168
33MP0005666_abnormal_adipose_tissue1.58470498
34MP0002089_abnormal_postnatal_growth/wei1.57128441
35MP0003566_abnormal_cell_adhesion1.54872167
36MP0005423_abnormal_somatic_nervous1.52380743
37MP0002184_abnormal_innervation1.50624855
38MP0003787_abnormal_imprinting1.47580150
39MP0003119_abnormal_digestive_system1.47308066
40MP0005375_adipose_tissue_phenotype1.43721061
41MP0003091_abnormal_cell_migration1.42275288
42MP0002572_abnormal_emotion/affect_behav1.42254325
43MP0003385_abnormal_body_wall1.40864125
44MP0002909_abnormal_adrenal_gland1.40686925
45MP0001968_abnormal_touch/_nociception1.38600381
46MP0004185_abnormal_adipocyte_glucose1.38089243
47MP0010234_abnormal_vibrissa_follicle1.37148028
48MP0000566_synostosis1.34738258
49MP0009745_abnormal_behavioral_response1.33994276
50MP0002734_abnormal_mechanical_nocicepti1.33933676
51MP0000733_abnormal_muscle_development1.29314314
52MP0004233_abnormal_muscle_weight1.28739775
53MP0008961_abnormal_basal_metabolism1.28023965
54MP0003121_genomic_imprinting1.26896418
55MP0001970_abnormal_pain_threshold1.26443060
56MP0002249_abnormal_larynx_morphology1.24768509
57MP0009046_muscle_twitch1.21062654
58MP0002254_reproductive_system_inflammat1.20487834
59MP0005670_abnormal_white_adipose1.20372607
60MP0002557_abnormal_social/conspecific_i1.19366234
61MP0003453_abnormal_keratinocyte_physiol1.18946494
62MP0003634_abnormal_glial_cell1.18194369
63MP0008877_abnormal_DNA_methylation1.17708054
64MP0003646_muscle_fatigue1.16696447
65MP0001348_abnormal_lacrimal_gland1.16613558
66MP0004381_abnormal_hair_follicle1.16375912
67MP0004811_abnormal_neuron_physiology1.15956856
68MP0000955_abnormal_spinal_cord1.15914112
69MP0002064_seizures1.15179441
70MP0000681_abnormal_thyroid_gland1.14827378
71MP0003436_decreased_susceptibility_to1.14610702
72MP0002272_abnormal_nervous_system1.11504931
73MP0003690_abnormal_glial_cell1.11458718
74MP0002084_abnormal_developmental_patter1.10892555
75MP0004130_abnormal_muscle_cell1.10676782
76MP0005623_abnormal_meninges_morphology1.09767079
77MP0002269_muscular_atrophy1.09720212
78MP0005257_abnormal_intraocular_pressure1.08879054
79MP0003300_gastrointestinal_ulcer1.06413532
80MP0002233_abnormal_nose_morphology1.06320007
81MP0000747_muscle_weakness1.06250148
82MP0004084_abnormal_cardiac_muscle1.02767044
83MP0010630_abnormal_cardiac_muscle1.00811206
84MP0004087_abnormal_muscle_fiber1.00548166
85MP0009379_abnormal_foot_pigmentation0.99635436
86MP0003075_altered_response_to0.99402000
87MP0004145_abnormal_muscle_electrophysio0.98453367
88MP0001502_abnormal_circadian_rhythm0.98324531
89MP0004272_abnormal_basement_membrane0.97502840
90MP0001346_abnormal_lacrimal_gland0.94771758
91MP0000678_abnormal_parathyroid_gland0.94686617
92MP0005503_abnormal_tendon_morphology0.94512275
93MP0004947_skin_inflammation0.94429496
94MP0009840_abnormal_foam_cell0.94030957
95MP0003191_abnormal_cellular_cholesterol0.92404736
96MP0004885_abnormal_endolymph0.91203135
97MP0003879_abnormal_hair_cell0.91183278
98MP0000767_abnormal_smooth_muscle0.90866594
99MP0008872_abnormal_physiological_respon0.89950021
100MP0002152_abnormal_brain_morphology0.89202108
101MP0008874_decreased_physiological_sensi0.88921494
102MP0002736_abnormal_nociception_after0.88081521
103MP0000920_abnormal_myelination0.87927231
104MP0005330_cardiomyopathy0.87859064
105MP0009780_abnormal_chondrocyte_physiolo0.87531970
106MP0003115_abnormal_respiratory_system0.85960187
107MP0009384_cardiac_valve_regurgitation0.84938481
108MP0005377_hearing/vestibular/ear_phenot0.84853398
109MP0003878_abnormal_ear_physiology0.84853398
110MP0005508_abnormal_skeleton_morphology0.83524190
111MP0005076_abnormal_cell_differentiation0.82537026
112MP0002106_abnormal_muscle_physiology0.82533463
113MP0003861_abnormal_nervous_system0.81947615
114MP0003137_abnormal_impulse_conducting0.80945862
115MP0002066_abnormal_motor_capabilities/c0.80635891
116MP0003183_abnormal_peptide_metabolism0.80192474
117MP0002882_abnormal_neuron_morphology0.80170172
118MP0004197_abnormal_fetal_growth/weight/0.79860462
119MP0009053_abnormal_anal_canal0.79687907
120MP0005248_abnormal_Harderian_gland0.79290094
121MP0003942_abnormal_urinary_system0.79170569
122MP0003221_abnormal_cardiomyocyte_apopto0.79005699
123MP0000604_amyloidosis0.78709984
124MP0008569_lethality_at_weaning0.78600942
125MP0004085_abnormal_heartbeat0.77866541
126MP0000759_abnormal_skeletal_muscle0.76872293
127MP0002085_abnormal_embryonic_tissue0.75901440
128MP0002998_abnormal_bone_remodeling0.74929098
129MP0001486_abnormal_startle_reflex0.74268545
130MP0009672_abnormal_birth_weight0.74160364
131MP0003252_abnormal_bile_duct0.73955697
132MP0000858_altered_metastatic_potential0.73395903
133MP0002796_impaired_skin_barrier0.73241215
134MP0005499_abnormal_olfactory_system0.72947630
135MP0005394_taste/olfaction_phenotype0.72947630
136MP0004215_abnormal_myocardial_fiber0.72947586
137MP0000266_abnormal_heart_morphology0.71090739
138MP0002060_abnormal_skin_morphology0.70235473
139MP0000003_abnormal_adipose_tissue0.69360299
140MP0002396_abnormal_hematopoietic_system0.69131842
141MP0002116_abnormal_craniofacial_bone0.69038566
142MP0008770_decreased_survivor_rate0.68431395
143MP0006138_congestive_heart_failure0.68368212
144MP0002932_abnormal_joint_morphology0.68271145
145MP0005167_abnormal_blood-brain_barrier0.68267846
146MP0001730_embryonic_growth_arrest0.68016402
147MP0001340_abnormal_eyelid_morphology0.67859782
148MP0000778_abnormal_nervous_system0.67855360
149MP0005501_abnormal_skin_physiology0.67760673
150MP0003763_abnormal_thymus_physiology0.67607334
151MP0000750_abnormal_muscle_regeneration0.67192065
152MP0000462_abnormal_digestive_system0.66924898
153MP0002896_abnormal_bone_mineralization0.65819405
154MP0003880_abnormal_central_pattern0.65587338
155MP0005621_abnormal_cell_physiology0.65394274
156MP0002933_joint_inflammation0.65156921
157MP0000428_abnormal_craniofacial_morphol0.64512472
158MP0002114_abnormal_axial_skeleton0.64469649

Predicted human phenotypes

RankGene SetZ-score
1Annular pancreas (HP:0001734)4.39306566
2Myokymia (HP:0002411)3.77423677
3Protrusio acetabuli (HP:0003179)3.52744346
4Hyperacusis (HP:0010780)3.42137035
5Abdominal situs inversus (HP:0003363)3.34368207
6Abnormality of abdominal situs (HP:0011620)3.34368207
7Abnormality of the lower motor neuron (HP:0002366)3.32140964
8Renal duplication (HP:0000075)3.18353810
9Visual hallucinations (HP:0002367)3.15335349
10Striae distensae (HP:0001065)3.10811470
11Insomnia (HP:0100785)3.06698882
12Congenital malformation of the right heart (HP:0011723)3.01270302
13Double outlet right ventricle (HP:0001719)3.01270302
14Ventricular fibrillation (HP:0001663)2.86509273
15Ulnar bowing (HP:0003031)2.83749808
16Elfin facies (HP:0004428)2.79703153
17Hypercortisolism (HP:0001578)2.74248964
18Broad face (HP:0000283)2.72716780
19Ankyloglossia (HP:0010296)2.67778590
20Pointed chin (HP:0000307)2.64030002
21Supranuclear gaze palsy (HP:0000605)2.58585572
22Renovascular hypertension (HP:0100817)2.53333580
23Premature rupture of membranes (HP:0001788)2.52567777
24Sudden death (HP:0001699)2.52166950
25Increased connective tissue (HP:0009025)2.52001344
26Shawl scrotum (HP:0000049)2.51454062
27Enlarged penis (HP:0000040)2.50829601
28Late onset (HP:0003584)2.45871551
29Flat cornea (HP:0007720)2.44882780
30Disproportionate tall stature (HP:0001519)2.44026372
31Limb hypertonia (HP:0002509)2.39364999
32Turricephaly (HP:0000262)2.37816468
33Stridor (HP:0010307)2.36688508
34Distal lower limb amyotrophy (HP:0008944)2.35861140
35Truncus arteriosus (HP:0001660)2.34622931
36Abnormality of skeletal muscle fiber size (HP:0012084)2.32400855
37Adenoma sebaceum (HP:0009720)2.31582655
38Angiofibromas (HP:0010615)2.31582655
39Broad metatarsal (HP:0001783)2.30755302
40Fragile skin (HP:0001030)2.30423982
41Mitral regurgitation (HP:0001653)2.28966974
42Thin bony cortex (HP:0002753)2.26016153
43Testicular neoplasm (HP:0010788)2.25922363
44Lymphangioma (HP:0100764)2.23196842
45Centrally nucleated skeletal muscle fibers (HP:0003687)2.22647622
46Overriding aorta (HP:0002623)2.22580281
47Cervical subluxation (HP:0003308)2.20766926
48Biconcave vertebral bodies (HP:0004586)2.19330776
49Lower limb amyotrophy (HP:0007210)2.18493222
50Ependymoma (HP:0002888)2.18160482
51Myopathic facies (HP:0002058)2.17025263
52Vertebral compression fractures (HP:0002953)2.16941906
53Neurofibrillary tangles (HP:0002185)2.16419186
54Atrioventricular canal defect (HP:0006695)2.14722621
55Abnormality of the diencephalon (HP:0010662)2.13960710
56Cerebral inclusion bodies (HP:0100314)2.13895224
57Genu recurvatum (HP:0002816)2.12354126
58Asymmetric septal hypertrophy (HP:0001670)2.12309569
59Bowel diverticulosis (HP:0005222)2.09747469
60Myotonia (HP:0002486)2.07266391
61Long palpebral fissure (HP:0000637)2.07208964
62Thin ribs (HP:0000883)2.05754927
63Focal seizures (HP:0007359)2.04419121
64Polygenic inheritance (HP:0010982)2.04273148
65Bundle branch block (HP:0011710)2.03567256
66Achilles tendon contracture (HP:0001771)2.02793909
67Abnormality of the aortic arch (HP:0012303)2.01864096
68Poikiloderma (HP:0001029)2.01190054
69Spinal rigidity (HP:0003306)2.00518870
70Impaired vibration sensation in the lower limbs (HP:0002166)1.99908825
71Mildly elevated creatine phosphokinase (HP:0008180)1.99846570
72Abnormality of the fingertips (HP:0001211)1.99606037
73Distal lower limb muscle weakness (HP:0009053)1.97530160
74Broad palm (HP:0001169)1.96656579
75Abnormality of the Achilles tendon (HP:0005109)1.93720108
76Premature skin wrinkling (HP:0100678)1.93614573
77Action tremor (HP:0002345)1.93523664
78Spinal canal stenosis (HP:0003416)1.92938423
79Cerebral aneurysm (HP:0004944)1.91135370
80Cellulitis (HP:0100658)1.90054780
81Abnormality of the astrocytes (HP:0100707)1.89770770
82Astrocytoma (HP:0009592)1.89770770
83Hamartoma of the eye (HP:0010568)1.89553419
84Upper limb amyotrophy (HP:0009129)1.89195587
85Distal upper limb amyotrophy (HP:0007149)1.89195587
86Blue sclerae (HP:0000592)1.89034545
87Metaphyseal cupping (HP:0003021)1.88037786
88Intellectual disability, profound (HP:0002187)1.86655839
89Germ cell neoplasia (HP:0100728)1.85743180
90Abnormality of the thoracic spine (HP:0100711)1.85262334
91Fibroma (HP:0010614)1.85117414
92Abnormality of oral frenula (HP:0000190)1.84753116
93Transposition of the great arteries (HP:0001669)1.84246259
94Abnormal connection of the cardiac segments (HP:0011545)1.84246259
95Abnormal ventriculo-arterial connection (HP:0011563)1.84246259
96Neoplasm of the peripheral nervous system (HP:0100007)1.83996545
97Difficulty running (HP:0009046)1.83035717
98Shallow orbits (HP:0000586)1.82730010
99Neoplasm of the heart (HP:0100544)1.82171943
100Hemorrhage of the eye (HP:0011885)1.82076933
101Genetic anticipation (HP:0003743)1.81740553
102Aneurysm (HP:0002617)1.81307839
103Arnold-Chiari malformation (HP:0002308)1.80654074
104Right ventricular cardiomyopathy (HP:0011663)1.79902724
105Intestinal polyp (HP:0005266)1.79760241
106Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.79537857
107Type 1 muscle fiber predominance (HP:0003803)1.79327995
108Rectal prolapse (HP:0002035)1.78684000
109Depression (HP:0000716)1.78392433
110Broad distal phalanx of finger (HP:0009836)1.77296006
111Ventricular tachycardia (HP:0004756)1.77214379
112Flat acetabular roof (HP:0003180)1.76689877
113Megalocornea (HP:0000485)1.75798462
114Bicornuate uterus (HP:0000813)1.75642783
115Lower limb asymmetry (HP:0100559)1.75594392
116Hand muscle atrophy (HP:0009130)1.75356490
117Neuronal loss in central nervous system (HP:0002529)1.75351166
118Mask-like facies (HP:0000298)1.74371602
119Focal motor seizures (HP:0011153)1.74145879
120Bronchomalacia (HP:0002780)1.73979612
121Intestinal polyposis (HP:0200008)1.73250049
122Rapidly progressive (HP:0003678)1.73222179
123Asymmetry of the thorax (HP:0001555)1.73126679
124Diplopia (HP:0000651)1.72633397
125Abnormality of binocular vision (HP:0011514)1.72633397
126Abnormality of the distal phalanx of the thumb (HP:0009617)1.72013477
127Wormian bones (HP:0002645)1.70919433
128Ventricular arrhythmia (HP:0004308)1.70779349
129Atonic seizures (HP:0010819)1.70676299
130Hyperparathyroidism (HP:0000843)1.69776031
131Torticollis (HP:0000473)1.69770949
132Dilatation of the ascending aorta (HP:0005111)1.69770381
133Sacral dimple (HP:0000960)1.69552097
134Ankle clonus (HP:0011448)1.69205005
135Dysmetric saccades (HP:0000641)1.68726980
136Hypoventilation (HP:0002791)1.68663502
137Growth hormone excess (HP:0000845)1.68575499
138Precocious puberty (HP:0000826)1.68527610
139Emphysema (HP:0002097)1.68513238
140Short 4th metacarpal (HP:0010044)1.68351834
141Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.68351834
142Rib fusion (HP:0000902)1.67262660
143Atrophic scars (HP:0001075)1.66456243
144Fibrous tissue neoplasm (HP:0012316)1.66236517
145Aplasia involving bones of the extremities (HP:0009825)1.65894985
146Aplasia involving bones of the upper limbs (HP:0009823)1.65894985
147Aplasia of the phalanges of the hand (HP:0009802)1.65894985
148Bowel incontinence (HP:0002607)1.65868406
149Focal dystonia (HP:0004373)1.65521409
150EMG: neuropathic changes (HP:0003445)1.65211346
151Abnormality of the periventricular white matter (HP:0002518)1.64506931
152Easy fatigability (HP:0003388)1.64496762
153Difficulty climbing stairs (HP:0003551)1.63563110
154Hyperextensible skin (HP:0000974)1.63461641
155Mitral valve prolapse (HP:0001634)1.63391456
156Clonus (HP:0002169)1.63022405
157Obstructive sleep apnea (HP:0002870)1.61834890
158Supernumerary nipples (HP:0002558)1.61777431
159Round ear (HP:0100830)1.61274443
160Bladder diverticulum (HP:0000015)1.60503946
161Hypercalcemia (HP:0003072)1.60277639
162Atrioventricular block (HP:0001678)1.60066547
163Increased variability in muscle fiber diameter (HP:0003557)1.60015521
164Prolonged QT interval (HP:0001657)1.60003005
165Segmental peripheral demyelination/remyelination (HP:0003481)1.59988589
166Palpitations (HP:0001962)1.59801239
167Hemiplegia (HP:0002301)1.59036902
168Deep palmar crease (HP:0006191)1.58369460
169Exercise-induced myalgia (HP:0003738)1.57945623
170Sleep apnea (HP:0010535)1.56924303
171Spinal cord lesions (HP:0100561)1.56637877
172Syringomyelia (HP:0003396)1.56637877

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.33944199
2PKN23.53487442
3SMG13.38797453
4PRPF4B3.23809202
5KSR23.15286140
6MAP3K92.86353096
7MAP2K32.79423370
8SIK12.73180247
9LATS22.64333499
10ERN12.61194626
11EEF2K2.30404850
12PRKD22.08387205
13MAP3K32.05019579
14PRKD32.01048399
15MAP3K41.94186561
16TAOK21.93659144
17NTRK31.87490073
18TAOK11.80355796
19NEK11.78219433
20MAP3K21.76914296
21CDK121.68200827
22PAK61.63590320
23MINK11.54955135
24RIPK41.45218401
25FGFR41.44882221
26NTRK11.44035347
27RET1.42988748
28PRKCH1.38287941
29MAP2K41.34454448
30ICK1.34387153
31CAMKK11.32311975
32PDGFRA1.31856773
33TYRO31.30883441
34TNK21.29280539
35LMTK21.28569467
36MAP3K131.24109782
37ARAF1.23423201
38KIT1.22794262
39ILK1.22765360
40MARK11.22039106
41RIPK11.13842314
42GRK51.13822481
43MAP4K11.10452704
44DAPK21.09570643
45PHKG11.09365781
46PHKG21.09365781
47MAP3K101.08642179
48PDPK11.05797395
49ALK1.04667321
50IRAK31.04569125
51PINK11.02799861
52TIE11.02546660
53NTRK21.00840749
54MST1R0.97676309
55DMPK0.96499661
56SGK30.95081246
57DDR20.94309691
58CDK190.93676354
59STK380.92639000
60DAPK10.92148695
61MAPK120.89864110
62EPHA40.87879663
63MAP3K60.87581345
64SCYL20.86003542
65UHMK10.84574687
66BRAF0.83704703
67TTN0.83572660
68SGK20.82517906
69EPHB10.81875325
70RPS6KL10.78512403
71RPS6KC10.78512403
72TESK10.77965237
73IRAK20.75908680
74PTK20.72021148
75MAP2K60.71547034
76FES0.70097819
77MAP3K10.69931552
78MARK20.68240486
79LATS10.68011531
80EPHA20.64707609
81HIPK20.63618034
82MAP2K20.63526200
83CDK50.63056362
84GRK60.62953225
85SGK2230.62375833
86SGK4940.62375833
87MATK0.61451970
88PRKG20.60843167
89CDK150.60088951
90CAMK1D0.60026697
91CDK11A0.59572052
92DYRK1B0.58319184
93MTOR0.56964789
94RPS6KA60.56461691
95FLT30.55666175
96STK110.55653328
97CDC42BPA0.54374664
98PAK40.53931766
99KSR10.53844994
100CDC70.53789526
101CDK180.53682294
102RPS6KA20.53448303
103MAPK70.51927428
104CDK140.50927994
105MAP2K10.50466460
106ZAP700.49928535
107MAP2K70.49500238
108MAPK110.49409917
109MAP3K110.49252217
110PIK3CA0.49185120
111EPHB20.48591596
112NME20.48194232
113LRRK20.48190379
114SIK20.47828209
115PAK20.47006668
116RPS6KB20.46997829
117PTK60.46202523
118TESK20.46118884
119MAPK100.43112366
120BRSK10.42905460
121CAMK10.42547385
122DAPK30.41301889
123RPS6KA10.40152479
124BMX0.40021942
125TGFBR10.39744835
126MAPKAPK30.39627587
127MAPK40.38779231
128IRAK40.38564845
129PDK10.38392002
130MAP3K80.36390577
131MAP3K70.33817393
132CAMK40.33111318
133CSNK1E0.32138794
134CDK90.30466397
135RAF10.30437361
136MAP3K120.30339220

Predicted pathways (KEGG)

RankGene SetZ-score
1Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.35635638
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.23900675
3Synaptic vesicle cycle_Homo sapiens_hsa047212.09435824
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.05346704
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.04068605
6Notch signaling pathway_Homo sapiens_hsa043302.03881309
7Long-term potentiation_Homo sapiens_hsa047201.81193105
8Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.73401361
9Nitrogen metabolism_Homo sapiens_hsa009101.68832229
10GnRH signaling pathway_Homo sapiens_hsa049121.68678167
11Olfactory transduction_Homo sapiens_hsa047401.65339018
12Other glycan degradation_Homo sapiens_hsa005111.58789264
13Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.57713576
14Glioma_Homo sapiens_hsa052141.56923906
15Dopaminergic synapse_Homo sapiens_hsa047281.53131194
16Circadian entrainment_Homo sapiens_hsa047131.52316490
17mTOR signaling pathway_Homo sapiens_hsa041501.47509832
18Thyroid cancer_Homo sapiens_hsa052161.45410488
19Gap junction_Homo sapiens_hsa045401.44255191
20Oocyte meiosis_Homo sapiens_hsa041141.43214878
21Estrogen signaling pathway_Homo sapiens_hsa049151.42960419
22Non-small cell lung cancer_Homo sapiens_hsa052231.42697227
23Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.40947686
24Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.38023075
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.36926292
26Glutamatergic synapse_Homo sapiens_hsa047241.35960135
27Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.35353036
28GABAergic synapse_Homo sapiens_hsa047271.35101185
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.34223729
30Cyanoamino acid metabolism_Homo sapiens_hsa004601.33949995
31Gastric acid secretion_Homo sapiens_hsa049711.33220505
32Central carbon metabolism in cancer_Homo sapiens_hsa052301.32890798
33Amphetamine addiction_Homo sapiens_hsa050311.32570312
34Insulin secretion_Homo sapiens_hsa049111.32377570
35Endometrial cancer_Homo sapiens_hsa052131.31414918
36Cholinergic synapse_Homo sapiens_hsa047251.31230180
37Prion diseases_Homo sapiens_hsa050201.30968567
38Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.30094415
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.29399732
40Salivary secretion_Homo sapiens_hsa049701.29108416
41Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.26948115
42Oxytocin signaling pathway_Homo sapiens_hsa049211.26021643
43Neurotrophin signaling pathway_Homo sapiens_hsa047221.25441413
44B cell receptor signaling pathway_Homo sapiens_hsa046621.24966170
45Biosynthesis of amino acids_Homo sapiens_hsa012301.22110995
46Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.20649287
47VEGF signaling pathway_Homo sapiens_hsa043701.15555620
48Melanogenesis_Homo sapiens_hsa049161.15467302
49Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14193289
50Dorso-ventral axis formation_Homo sapiens_hsa043201.12831070
51Bile secretion_Homo sapiens_hsa049761.11425213
52Nicotine addiction_Homo sapiens_hsa050331.10330055
53Insulin signaling pathway_Homo sapiens_hsa049101.10135805
54Thyroid hormone signaling pathway_Homo sapiens_hsa049191.07730401
55Pancreatic cancer_Homo sapiens_hsa052121.06987006
56Morphine addiction_Homo sapiens_hsa050321.06192907
57Dilated cardiomyopathy_Homo sapiens_hsa054141.05632304
58Bladder cancer_Homo sapiens_hsa052191.04184132
59Focal adhesion_Homo sapiens_hsa045101.03557296
60Chronic myeloid leukemia_Homo sapiens_hsa052201.02789802
61Glucagon signaling pathway_Homo sapiens_hsa049221.01528933
62Arginine biosynthesis_Homo sapiens_hsa002201.01396724
63Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.00196758
64Type II diabetes mellitus_Homo sapiens_hsa049300.99887995
65Long-term depression_Homo sapiens_hsa047300.99273180
66Cocaine addiction_Homo sapiens_hsa050300.97847303
67AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.97170670
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.96940242
69Glycosaminoglycan degradation_Homo sapiens_hsa005310.96819988
70Cardiac muscle contraction_Homo sapiens_hsa042600.96638400
71Carbon metabolism_Homo sapiens_hsa012000.95318398
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.93292317
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.90500372
74Endocytosis_Homo sapiens_hsa041440.90093134
75Inositol phosphate metabolism_Homo sapiens_hsa005620.90090617
76Taste transduction_Homo sapiens_hsa047420.88872562
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88789490
78cAMP signaling pathway_Homo sapiens_hsa040240.88439546
79Pentose phosphate pathway_Homo sapiens_hsa000300.88194626
80Hippo signaling pathway_Homo sapiens_hsa043900.88111760
81Renin secretion_Homo sapiens_hsa049240.85581948
82Selenocompound metabolism_Homo sapiens_hsa004500.85134155
83Leukocyte transendothelial migration_Homo sapiens_hsa046700.84774671
84ErbB signaling pathway_Homo sapiens_hsa040120.84683652
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.83505399
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.82992827
87Colorectal cancer_Homo sapiens_hsa052100.81659581
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.81233976
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.80938748
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.79230595
91cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79175165
92Basal cell carcinoma_Homo sapiens_hsa052170.77416240
93Proteoglycans in cancer_Homo sapiens_hsa052050.76631158
94Calcium signaling pathway_Homo sapiens_hsa040200.75118007
95Amoebiasis_Homo sapiens_hsa051460.74719950
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.74092491
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.74004123
98Hedgehog signaling pathway_Homo sapiens_hsa043400.73630026
99Osteoclast differentiation_Homo sapiens_hsa043800.73576849
100Tight junction_Homo sapiens_hsa045300.73536631
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71877850
102Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.71621417
103Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71486145
104Vitamin B6 metabolism_Homo sapiens_hsa007500.71375987
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.70893673
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70478072
107Thyroid hormone synthesis_Homo sapiens_hsa049180.69976689
108Rap1 signaling pathway_Homo sapiens_hsa040150.68441288
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67700209
110Choline metabolism in cancer_Homo sapiens_hsa052310.67073514
111Prostate cancer_Homo sapiens_hsa052150.65163550
112Wnt signaling pathway_Homo sapiens_hsa043100.65063414
113ECM-receptor interaction_Homo sapiens_hsa045120.64601331
114Serotonergic synapse_Homo sapiens_hsa047260.62933654
115HIF-1 signaling pathway_Homo sapiens_hsa040660.62116302
116Hepatitis C_Homo sapiens_hsa051600.61736915
117Prolactin signaling pathway_Homo sapiens_hsa049170.61688838
118Fructose and mannose metabolism_Homo sapiens_hsa000510.60968688
119T cell receptor signaling pathway_Homo sapiens_hsa046600.60011499
120Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59885502
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59759667
122MAPK signaling pathway_Homo sapiens_hsa040100.59674525
123MicroRNAs in cancer_Homo sapiens_hsa052060.59538145
124Pyruvate metabolism_Homo sapiens_hsa006200.58971640
125Platelet activation_Homo sapiens_hsa046110.58532082
126Axon guidance_Homo sapiens_hsa043600.58345385
127AMPK signaling pathway_Homo sapiens_hsa041520.57848928
128Renal cell carcinoma_Homo sapiens_hsa052110.57620956
129Acute myeloid leukemia_Homo sapiens_hsa052210.57340788
130Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.56238105
131Adherens junction_Homo sapiens_hsa045200.55900067
132Insulin resistance_Homo sapiens_hsa049310.55857908
133Alcoholism_Homo sapiens_hsa050340.55680053
134Sulfur relay system_Homo sapiens_hsa041220.55565544
135Melanoma_Homo sapiens_hsa052180.55441607
136Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.55379125
137Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54876298
138Galactose metabolism_Homo sapiens_hsa000520.54862652

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