BTBD7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)4.40248446
2negative regulation of keratinocyte proliferation (GO:0010839)3.90454430
3nuclear pore organization (GO:0006999)3.77152425
4artery development (GO:0060840)3.71296136
5mitotic sister chromatid cohesion (GO:0007064)3.68523047
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.62823418
7cytoplasmic mRNA processing body assembly (GO:0033962)3.62564050
8hippo signaling (GO:0035329)3.62129406
9intestinal epithelial cell development (GO:0060576)3.61684339
10neural tube formation (GO:0001841)3.48692811
11pre-miRNA processing (GO:0031054)3.36123195
12lymphangiogenesis (GO:0001946)3.35497230
13interkinetic nuclear migration (GO:0022027)3.35481281
14pore complex assembly (GO:0046931)3.28233997
15negative regulation of systemic arterial blood pressure (GO:0003085)3.21674035
16NLS-bearing protein import into nucleus (GO:0006607)3.18105977
17pericardium development (GO:0060039)3.16753916
18histone H3-K9 demethylation (GO:0033169)3.15778883
19negative regulation of translation, ncRNA-mediated (GO:0040033)3.13106249
20regulation of translation, ncRNA-mediated (GO:0045974)3.13106249
21negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.13106249
22regulation of keratinocyte proliferation (GO:0010837)3.06397358
23positive regulation of SMAD protein import into nucleus (GO:0060391)3.03613636
24regulation of RNA export from nucleus (GO:0046831)3.01231140
25regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.97929822
26kidney morphogenesis (GO:0060993)2.97522039
27peptidyl-lysine dimethylation (GO:0018027)2.97145898
28insulin-like growth factor receptor signaling pathway (GO:0048009)2.96915851
29regulation of SMAD protein import into nucleus (GO:0060390)2.95989773
30negative regulation of DNA repair (GO:0045738)2.95403071
31regulation of protein polyubiquitination (GO:1902914)2.94575345
32endoderm formation (GO:0001706)2.92909834
33limb bud formation (GO:0060174)2.92455159
34positive regulation of gastrulation (GO:2000543)2.91412527
35genitalia morphogenesis (GO:0035112)2.87608965
36negative regulation of axon extension involved in axon guidance (GO:0048843)2.78597207
37keratinocyte development (GO:0003334)2.77174615
38regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.76783514
39protein K11-linked deubiquitination (GO:0035871)2.75228648
40planar cell polarity pathway involved in neural tube closure (GO:0090179)2.75032941
41cell migration involved in sprouting angiogenesis (GO:0002042)2.73984285
42regulation of establishment of cell polarity (GO:2000114)2.72261292
43* regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.71684834
44desmosome organization (GO:0002934)2.71089531
45regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.70772657
46cell adhesion mediated by integrin (GO:0033627)2.69230181
47smooth muscle tissue development (GO:0048745)2.68864074
48vascular endothelial growth factor signaling pathway (GO:0038084)2.68065459
49epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.66751741
50negative regulation of axon guidance (GO:1902668)2.66492807
51regulation of meiosis I (GO:0060631)2.64011188
52embryonic foregut morphogenesis (GO:0048617)2.63284954
53auditory receptor cell differentiation (GO:0042491)2.62492576
54heterochromatin organization (GO:0070828)2.62214747
55collagen fibril organization (GO:0030199)2.59172502
56regulation of posttranscriptional gene silencing (GO:0060147)2.59066079
57regulation of gene silencing by miRNA (GO:0060964)2.59066079
58regulation of gene silencing by RNA (GO:0060966)2.59066079
59gene silencing by RNA (GO:0031047)2.59064874
60retina layer formation (GO:0010842)2.58875911
61prenylation (GO:0097354)2.58833775
62protein prenylation (GO:0018342)2.58833775
63monoubiquitinated protein deubiquitination (GO:0035520)2.58259424
64somite rostral/caudal axis specification (GO:0032525)2.58192934
65negative regulation of fatty acid transport (GO:2000192)2.58180162
66paraxial mesoderm development (GO:0048339)2.57930323
67regulation of establishment or maintenance of cell polarity (GO:0032878)2.57163449
68fibroblast migration (GO:0010761)2.56878486
69germ cell migration (GO:0008354)2.56625998
70lipid translocation (GO:0034204)2.55148005
71phospholipid translocation (GO:0045332)2.55148005
72lateral sprouting from an epithelium (GO:0060601)2.53851590
73protein heterotrimerization (GO:0070208)2.53371576
74neural crest cell development (GO:0014032)2.53111743
75nephron epithelium morphogenesis (GO:0072088)2.53062982
76nephron tubule morphogenesis (GO:0072078)2.53062982
77histone H3-K36 demethylation (GO:0070544)2.52976273
78histone lysine demethylation (GO:0070076)2.51584027
79positive regulation of histone deacetylation (GO:0031065)2.51304827
80cardiac right ventricle morphogenesis (GO:0003215)2.51091280
81establishment of protein localization to Golgi (GO:0072600)2.50784563
82gastrulation with mouth forming second (GO:0001702)2.50650660
83renal tubule morphogenesis (GO:0061333)2.49996832
84embryonic epithelial tube formation (GO:0001838)2.49507415
85lung lobe morphogenesis (GO:0060463)2.48034244
86regulation of sister chromatid cohesion (GO:0007063)2.47720242
87axon extension involved in axon guidance (GO:0048846)2.47614875
88neuron projection extension involved in neuron projection guidance (GO:1902284)2.47614875
89regulation of mitotic spindle organization (GO:0060236)2.47290313
90regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.46864493
91dorsal/ventral axis specification (GO:0009950)2.46751841
92synaptonemal complex assembly (GO:0007130)2.46428574
93endodermal cell differentiation (GO:0035987)2.43874207
94positive regulation of p38MAPK cascade (GO:1900745)2.43839030
95ectoderm development (GO:0007398)2.43502420
96negative regulation of Rho protein signal transduction (GO:0035024)2.43330798
97positive regulation of epithelial to mesenchymal transition (GO:0010718)2.43188179
98regulation of transforming growth factor beta2 production (GO:0032909)2.42776301
99epithelial tube formation (GO:0072175)2.42588618
100protein localization to microtubule cytoskeleton (GO:0072698)2.41152601
101histone demethylation (GO:0016577)2.40542139
102regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.39558392
103regulation of mesoderm development (GO:2000380)2.39277369
104mRNA transcription (GO:0009299)2.39222740
105regulation of histone H3-K9 methylation (GO:0051570)2.38414210
106hindbrain development (GO:0030902)2.37967875
107regulation of axon extension involved in axon guidance (GO:0048841)2.37818743
108appendage development (GO:0048736)2.37467018
109limb development (GO:0060173)2.37467018
110regulation of axon guidance (GO:1902667)2.34783950
111prostate gland growth (GO:0060736)2.34756937
112regulation of nucleobase-containing compound transport (GO:0032239)2.34333351
113hemidesmosome assembly (GO:0031581)2.34099554
114glomerulus development (GO:0032835)2.33912404
115magnesium ion transport (GO:0015693)2.33668293
116negative chemotaxis (GO:0050919)2.33414229
117glucocorticoid receptor signaling pathway (GO:0042921)2.32857210
118antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.32746022
119mesenchymal cell differentiation (GO:0048762)2.31760824
120replication fork processing (GO:0031297)2.31363313
121endothelial tube morphogenesis (GO:0061154)2.31246763
122morphogenesis of an endothelium (GO:0003159)2.31246763
123mRNA stabilization (GO:0048255)2.30947039
124RNA stabilization (GO:0043489)2.30947039
125regulation of heart morphogenesis (GO:2000826)2.29723842
126heart morphogenesis (GO:0003007)2.29429174
127cellular response to interferon-alpha (GO:0035457)2.29248098
128regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.28903267
129positive regulation of fatty acid beta-oxidation (GO:0032000)2.28509693
130UDP-N-acetylglucosamine metabolic process (GO:0006047)2.28344067
131regulation of sarcomere organization (GO:0060297)2.27808956
132inner ear receptor cell development (GO:0060119)2.27644044
133ovulation from ovarian follicle (GO:0001542)2.27347868
134negative regulation of chondrocyte differentiation (GO:0032331)2.26990619
135mitotic chromosome condensation (GO:0007076)2.26848357
136chromatin assembly (GO:0031497)2.26554679
137renal system development (GO:0072001)2.26255663
138coronary vasculature morphogenesis (GO:0060977)2.25894029
139cell-substrate junction assembly (GO:0007044)2.25821057
140skin morphogenesis (GO:0043589)2.25796812
141histone H3-K9 methylation (GO:0051567)2.25772077
142chondrocyte development (GO:0002063)2.25363581
143regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.24313787
144positive regulation of mitotic sister chromatid separation (GO:1901970)2.23827933
145positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.23827933
146positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.23827933
147positive regulation of glycogen biosynthetic process (GO:0045725)2.23795594
148regulation of DNA endoreduplication (GO:0032875)2.23401399
149myoblast fusion (GO:0007520)2.23385804
150positive regulation of embryonic development (GO:0040019)2.22830334
151plasma membrane repair (GO:0001778)2.21851799
152negative regulation of histone methylation (GO:0031061)2.21639590
153fucose catabolic process (GO:0019317)2.21525072
154L-fucose metabolic process (GO:0042354)2.21525072
155L-fucose catabolic process (GO:0042355)2.21525072
156urogenital system development (GO:0001655)2.20271749
157chondrocyte proliferation (GO:0035988)2.19762747
158regulation of centriole replication (GO:0046599)2.19578367
159blood vessel endothelial cell migration (GO:0043534)2.19438676
160apoptotic cell clearance (GO:0043277)2.18826263
161corticosteroid receptor signaling pathway (GO:0031958)2.18192226
162notochord development (GO:0030903)2.18159710
163embryonic pattern specification (GO:0009880)2.18114769
164synaptonemal complex organization (GO:0070193)2.18061393
165mesodermal cell differentiation (GO:0048333)2.17717297
166negative regulation of organ growth (GO:0046621)2.17365573
167regulation of hippo signaling (GO:0035330)2.17053948
168adherens junction assembly (GO:0034333)2.16846379
169positive regulation of catenin import into nucleus (GO:0035413)2.16787751
170heparin biosynthetic process (GO:0030210)2.16389343
171heparin metabolic process (GO:0030202)2.16389343
172embryonic axis specification (GO:0000578)2.15901344
173morphogenesis of an epithelial sheet (GO:0002011)2.15392307
174tryptophan catabolic process (GO:0006569)2.15278722
175indolalkylamine catabolic process (GO:0046218)2.15278722
176cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.15249630
177regulation of spindle organization (GO:0090224)2.14742114
178positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.14722541
179histone H3-K9 modification (GO:0061647)2.14308016
180patterning of blood vessels (GO:0001569)2.14236526
181basement membrane organization (GO:0071711)2.13594983
182positive regulation of hormone biosynthetic process (GO:0046886)2.13489228
183embryonic retina morphogenesis in camera-type eye (GO:0060059)2.12739738
184embryonic camera-type eye morphogenesis (GO:0048596)2.12253509
185positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.11438427
186endocardial cushion development (GO:0003197)2.11305300
187renal filtration (GO:0097205)2.10089936

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human4.62176708
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.45526347
3E2F7_22180533_ChIP-Seq_HELA_Human3.96667251
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.81601138
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.35364226
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.98772312
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.97897255
8GBX2_23144817_ChIP-Seq_PC3_Human2.58855227
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.57023641
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.42425881
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.31231442
12AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.22763130
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.21630297
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.15251548
15CLOCK_20551151_ChIP-Seq_293T_Human2.14579253
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.11894184
17PIAS1_25552417_ChIP-Seq_VCAP_Human2.04851397
18TAF15_26573619_Chip-Seq_HEK293_Human2.04795574
19HIF1A_21447827_ChIP-Seq_MCF-7_Human2.04784759
20TRIM28_21343339_ChIP-Seq_HEK293_Human2.01396518
21STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.99848501
22KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.98916602
23FOXO3_23340844_ChIP-Seq_DLD1_Human1.98652454
24AHR_22903824_ChIP-Seq_MCF-7_Human1.97650919
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.96517690
26ZNF274_21170338_ChIP-Seq_K562_Hela1.95463061
27SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.94991003
28FUS_26573619_Chip-Seq_HEK293_Human1.91298710
29VDR_22108803_ChIP-Seq_LS180_Human1.88093459
30P300_19829295_ChIP-Seq_ESCs_Human1.87129126
31BRD4_25478319_ChIP-Seq_HGPS_Human1.85475933
32RBPJ_22232070_ChIP-Seq_NCS_Mouse1.85406578
33ARNT_22903824_ChIP-Seq_MCF-7_Human1.83853126
34SMAD_19615063_ChIP-ChIP_OVARY_Human1.82648810
35MYC_22102868_ChIP-Seq_BL_Human1.79945612
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.77591954
37* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.75697792
38STAT6_21828071_ChIP-Seq_BEAS2B_Human1.74796639
39TCF7_22412390_ChIP-Seq_EML_Mouse1.74629876
40RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.73898341
41SMAD4_21799915_ChIP-Seq_A2780_Human1.72213020
42CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.71610064
43FOXM1_26456572_ChIP-Seq_MCF-7_Human1.70566037
44AR_21909140_ChIP-Seq_LNCAP_Human1.69284614
45EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.68379357
46EWS_26573619_Chip-Seq_HEK293_Human1.68096808
47HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.67670457
48ER_23166858_ChIP-Seq_MCF-7_Human1.65755028
49STAT3_23295773_ChIP-Seq_U87_Human1.65058047
50ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.63111253
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.62979780
52TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.60330308
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.60199967
54MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.58626099
55NFIB_24661679_ChIP-Seq_LUNG_Mouse1.58624616
56CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.57590037
57RARG_19884340_ChIP-ChIP_MEFs_Mouse1.57580190
58MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.57434610
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.57377045
60PPAR_26484153_Chip-Seq_NCI-H1993_Human1.56581261
61STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.55933238
62* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.54725007
63* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.54725007
64DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.53901569
65BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.52549701
66TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.52529058
67KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.50290862
68NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.49071412
69NRF2_20460467_ChIP-Seq_MEFs_Mouse1.49071412
70FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.49023640
71WT1_19549856_ChIP-ChIP_CCG9911_Human1.47585509
72* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45745353
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.45708636
74ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.45561410
75KDM2B_26808549_Chip-Seq_DND41_Human1.45266397
76FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.45184568
77CDX2_19796622_ChIP-Seq_MESCs_Mouse1.44498686
78OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44059944
79PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43797991
80CJUN_26792858_Chip-Seq_BT549_Human1.43544009
81CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.41521017
82NR3C1_21868756_ChIP-Seq_MCF10A_Human1.40275990
83TCF4_23295773_ChIP-Seq_U87_Human1.40112565
84* UBF1/2_26484160_Chip-Seq_HMECs_Human1.39992665
85KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.38712619
86TP53_18474530_ChIP-ChIP_U2OS_Human1.38407589
87ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.38212395
88TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.38088264
89CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38075140
90TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.36905524
91SMAD3_21741376_ChIP-Seq_HESCs_Human1.36488039
92BCAT_22108803_ChIP-Seq_LS180_Human1.35696293
93TBX20_22328084_ChIP-Seq_HEART_Mouse1.35432665
94TBX20_22080862_ChIP-Seq_HEART_Mouse1.35432665
95AR_25329375_ChIP-Seq_VCAP_Human1.35248913
96* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.35158233
97UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31410241
98E2F4_17652178_ChIP-ChIP_JURKAT_Human1.31372663
99FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.30682490
100ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.30632513
101SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.30368312
102E2F1_21310950_ChIP-Seq_MCF-7_Human1.29961893
103STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.29748801
104EP300_21415370_ChIP-Seq_HL-1_Mouse1.29441430
105TP63_23658742_ChIP-Seq_EP156T_Human1.28998151
106SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.28980280
107P300_27058665_Chip-Seq_ZR-75-30cells_Human1.28952095
108ELK3_25401928_ChIP-Seq_HUVEC_Human1.28632290
109SOX9_24532713_ChIP-Seq_HFSC_Mouse1.28270350
110* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.28091809
111TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26695170
112POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26695170
113TP63_19390658_ChIP-ChIP_HaCaT_Human1.26459936
114ISL1_27105846_Chip-Seq_CPCs_Mouse1.26207460
115PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25402364
116ZNF217_24962896_ChIP-Seq_MCF-7_Human1.24391196
117HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.23750576
118FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.23175356
119TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22843464
120BMI1_23680149_ChIP-Seq_NPCS_Mouse1.21978701
121RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21959787
122FLI1_21867929_ChIP-Seq_TH2_Mouse1.20695708
123CDX2_22108803_ChIP-Seq_LS180_Human1.20266512
124SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.19730146
125SALL4_18804426_ChIP-ChIP_XEN_Mouse1.19652818
126ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18959281
127WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.17359759
128KDM2B_26808549_Chip-Seq_SUP-B15_Human1.17245563
129RXR_22108803_ChIP-Seq_LS180_Human1.17168469
130CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17103505
131IRF8_22096565_ChIP-ChIP_GC-B_Human1.15874817
132* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.15008466
133TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.14935173
134RUNX2_22187159_ChIP-Seq_PCA_Human1.14910038
135FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.13345022
136AR_21572438_ChIP-Seq_LNCaP_Human1.12570340
137NANOG_18555785_Chip-Seq_ESCs_Mouse1.12386782
138IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12341130
139CBP_20019798_ChIP-Seq_JUKART_Human1.12341130
140TCF4_18268006_ChIP-ChIP_LS174T_Human1.12203433
141EZH2_27294783_Chip-Seq_NPCs_Mouse1.12037482
142TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12003946
143RUNX1_27514584_Chip-Seq_MCF-7_Human1.11958412
144SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.11951940
145FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.11812161
146MAF_26560356_Chip-Seq_TH1_Human1.11399872
147GATA6_25053715_ChIP-Seq_YYC3_Human1.11049678
148CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.10734632
149TP53_16413492_ChIP-PET_HCT116_Human1.08487760
150SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08130479
151CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06849519
152ESR1_21235772_ChIP-Seq_MCF-7_Human1.06553569
153SMAD4_21741376_ChIP-Seq_EPCs_Human1.06520925
154IGF1R_20145208_ChIP-Seq_DFB_Human1.06495424
155KDM2B_26808549_Chip-Seq_JURKAT_Human1.06393284
156UTX_26944678_Chip-Seq_JUKART_Human1.05250465
157NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.05190078
158LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04830891
159NCOR1_26117541_ChIP-Seq_K562_Human1.04071781
160* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03821393
161CHD1_26751641_Chip-Seq_LNCaP_Human1.03223255
162EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01890153
163IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.01768592
164MYB_21317192_ChIP-Seq_ERMYB_Mouse1.01591628
165NOTCH1_21737748_ChIP-Seq_TLL_Human1.01427350
166KDM2B_26808549_Chip-Seq_REH_Human1.01409907
167MYB_26560356_Chip-Seq_TH1_Human1.01353051
168TCF4_22108803_ChIP-Seq_LS180_Human1.01234121
169ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.01064306
170POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00777488
171CBX2_27304074_Chip-Seq_ESCs_Mouse1.00768325
172GATA2_21666600_ChIP-Seq_HMVEC_Human1.00593484
173ATF3_27146783_Chip-Seq_COLON_Human0.99547438
174ESR1_20079471_ChIP-ChIP_T-47D_Human0.99018092
175RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98066032
176TBX3_20139965_ChIP-Seq_ESCs_Mouse0.95368838

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.57856112
2MP0000383_abnormal_hair_follicle3.54482278
3MP0008438_abnormal_cutaneous_collagen3.24905676
4MP0010678_abnormal_skin_adnexa2.96292428
5MP0010352_gastrointestinal_tract_polyps2.92077708
6MP0005076_abnormal_cell_differentiation2.84752932
7MP0000427_abnormal_hair_cycle2.28089710
8MP0005275_abnormal_skin_tensile2.20029324
9MP0004272_abnormal_basement_membrane2.09800589
10MP0002163_abnormal_gland_morphology2.06756616
11MP0005623_abnormal_meninges_morphology2.04439479
12MP0009780_abnormal_chondrocyte_physiolo2.01315140
13MP0003195_calcinosis2.00649640
14MP0000569_abnormal_digit_pigmentation1.98423356
15MP0003566_abnormal_cell_adhesion1.94812673
16MP0002138_abnormal_hepatobiliary_system1.94037231
17MP0005503_abnormal_tendon_morphology1.91040511
18MP0003300_gastrointestinal_ulcer1.87156754
19MP0000733_abnormal_muscle_development1.86038195
20MP0010307_abnormal_tumor_latency1.84222259
21MP0003279_aneurysm1.82168265
22MP0009053_abnormal_anal_canal1.76694104
23MP0005174_abnormal_tail_pigmentation1.74397054
24MP0000462_abnormal_digestive_system1.68665555
25MP0005023_abnormal_wound_healing1.65633236
26MP0000579_abnormal_nail_morphology1.61425994
27MP0010030_abnormal_orbit_morphology1.58240462
28MP0000537_abnormal_urethra_morphology1.56387181
29MP0006054_spinal_hemorrhage1.54569936
30MP0003091_abnormal_cell_migration1.52576456
31MP0009384_cardiac_valve_regurgitation1.50134103
32MP0002928_abnormal_bile_duct1.48477685
33MP0003943_abnormal_hepatobiliary_system1.45598740
34MP0002166_altered_tumor_susceptibility1.45383199
35MP0000371_diluted_coat_color1.45217933
36MP0002877_abnormal_melanocyte_morpholog1.45028946
37MP0002938_white_spotting1.43196464
38MP0000566_synostosis1.40749488
39MP0000762_abnormal_tongue_morphology1.40536373
40MP0010368_abnormal_lymphatic_system1.38163878
41MP0002254_reproductive_system_inflammat1.37455138
42MP0004197_abnormal_fetal_growth/weight/1.35928063
43MP0003941_abnormal_skin_development1.34706703
44MP0001286_abnormal_eye_development1.33145414
45MP0000647_abnormal_sebaceous_gland1.33014753
46MP0002160_abnormal_reproductive_system1.31366854
47MP0004808_abnormal_hematopoietic_stem1.30683359
48MP0002098_abnormal_vibrissa_morphology1.29908945
49MP0002233_abnormal_nose_morphology1.29302025
50MP0002088_abnormal_embryonic_growth/wei1.26393261
51MP0003984_embryonic_growth_retardation1.26058289
52MP0003045_fibrosis1.24989107
53MP0003283_abnormal_digestive_organ1.24068828
54MP0002086_abnormal_extraembryonic_tissu1.23327481
55MP0003935_abnormal_craniofacial_develop1.22993961
56MP0004084_abnormal_cardiac_muscle1.22918125
57MP0010234_abnormal_vibrissa_follicle1.22743877
58MP0010630_abnormal_cardiac_muscle1.22395260
59MP0002925_abnormal_cardiovascular_devel1.21423775
60MP0003115_abnormal_respiratory_system1.20832812
61MP0003136_yellow_coat_color1.20586246
62MP0000538_abnormal_urinary_bladder1.19790589
63MP0003385_abnormal_body_wall1.19740058
64MP0009278_abnormal_bone_marrow1.19640514
65MP0002060_abnormal_skin_morphology1.19536824
66MP0010386_abnormal_urinary_bladder1.19318426
67MP0003252_abnormal_bile_duct1.19253595
68MP0008007_abnormal_cellular_replicative1.19152434
69MP0000428_abnormal_craniofacial_morphol1.18850946
70MP0005380_embryogenesis_phenotype1.18708810
71MP0001672_abnormal_embryogenesis/_devel1.18708810
72MP0001915_intracranial_hemorrhage1.18278438
73MP0005248_abnormal_Harderian_gland1.18270315
74MP0000470_abnormal_stomach_morphology1.16767176
75MP0002168_other_aberrant_phenotype1.16612849
76MP0000767_abnormal_smooth_muscle1.15487097
77MP0003828_pulmonary_edema1.15043905
78MP0004185_abnormal_adipocyte_glucose1.15038065
79MP0000467_abnormal_esophagus_morphology1.14499492
80MP0002009_preneoplasia1.11521670
81MP0003567_abnormal_fetal_cardiomyocyte1.10621766
82MP0001958_emphysema1.10592926
83MP0000432_abnormal_head_morphology1.10207642
84MP0002177_abnormal_outer_ear1.09536436
85MP0002109_abnormal_limb_morphology1.09432673
86MP0005367_renal/urinary_system_phenotyp1.09414023
87MP0000516_abnormal_urinary_system1.09414023
88MP0005508_abnormal_skeleton_morphology1.09204570
89MP0002084_abnormal_developmental_patter1.08484553
90MP0002282_abnormal_trachea_morphology1.08472256
91MP0005666_abnormal_adipose_tissue1.06767560
92MP0002006_tumorigenesis1.06491909
93MP0003937_abnormal_limbs/digits/tail_de1.06381674
94MP0008877_abnormal_DNA_methylation1.04656018
95MP0001216_abnormal_epidermal_layer1.03779175
96MP0003936_abnormal_reproductive_system1.02837214
97MP0005409_darkened_coat_color1.02331246
98MP0001879_abnormal_lymphatic_vessel1.01653321
99MP0005389_reproductive_system_phenotype1.01498408
100MP0001730_embryonic_growth_arrest1.01409821
101MP0001849_ear_inflammation0.99529609
102MP0004233_abnormal_muscle_weight0.98843655
103MP0000534_abnormal_ureter_morphology0.98703916
104MP0005257_abnormal_intraocular_pressure0.98318730
105MP0002128_abnormal_blood_circulation0.97653707
106MP0003077_abnormal_cell_cycle0.96130600
107MP0008057_abnormal_DNA_replication0.95728553
108MP0002085_abnormal_embryonic_tissue0.95188020
109MP0005084_abnormal_gallbladder_morpholo0.94365274
110MP0002697_abnormal_eye_size0.94190794
111MP0002932_abnormal_joint_morphology0.93572589
112MP0009250_abnormal_appendicular_skeleto0.93440516
113MP0001299_abnormal_eye_distance/0.93349917
114MP0000350_abnormal_cell_proliferation0.92302539
115MP0002092_abnormal_eye_morphology0.92292249
116MP0001697_abnormal_embryo_size0.92208957
117MP0005187_abnormal_penis_morphology0.92169536
118MP0003942_abnormal_urinary_system0.91239884
119MP0002896_abnormal_bone_mineralization0.90988716
120MP0009703_decreased_birth_body0.90862224
121MP0000266_abnormal_heart_morphology0.90388377
122MP0002108_abnormal_muscle_morphology0.89772822
123MP0004134_abnormal_chest_morphology0.87573704
124MP0002116_abnormal_craniofacial_bone0.87359684
125MP0002095_abnormal_skin_pigmentation0.87286338
126MP0004043_abnormal_pH_regulation0.86451311
127MP0001293_anophthalmia0.86195153
128MP0000372_irregular_coat_pigmentation0.85988478
129MP0001614_abnormal_blood_vessel0.85799576
130MP0003890_abnormal_embryonic-extraembry0.84285918
131MP0002876_abnormal_thyroid_physiology0.83836936
132MP0002837_dystrophic_cardiac_calcinosis0.83313165
133MP0003755_abnormal_palate_morphology0.82444652
134MP0003950_abnormal_plasma_membrane0.82171849
135MP0002277_abnormal_respiratory_mucosa0.81956067
136MP0003111_abnormal_nucleus_morphology0.81296685
137MP0003453_abnormal_keratinocyte_physiol0.81126454
138MP0005375_adipose_tissue_phenotype0.79903760
139MP0005197_abnormal_uvea_morphology0.79618852
140MP0004087_abnormal_muscle_fiber0.79363392
141MP0001919_abnormal_reproductive_system0.78996410
142MP0003123_paternal_imprinting0.78992258
143MP0004264_abnormal_extraembryonic_tissu0.78790688
144MP0002111_abnormal_tail_morphology0.78562569
145MP0006138_congestive_heart_failure0.78380111
146MP0002115_abnormal_skeleton_extremities0.77046098
147MP0001784_abnormal_fluid_regulation0.76514974
148MP0001324_abnormal_eye_pigmentation0.76224910
149MP0003121_genomic_imprinting0.75102503
150MP0000049_abnormal_middle_ear0.74373729
151MP0000750_abnormal_muscle_regeneration0.74161749
152MP0008775_abnormal_heart_ventricle0.72865930
153MP0002089_abnormal_postnatal_growth/wei0.72841687
154MP0000613_abnormal_salivary_gland0.72646809
155MP0001191_abnormal_skin_condition0.70879379
156MP0001270_distended_abdomen0.70175302
157MP0005379_endocrine/exocrine_gland_phen0.69993178

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)3.83954196
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.83954196
3Protrusio acetabuli (HP:0003179)3.57963583
4Shallow orbits (HP:0000586)3.46343995
5Abnormal pancreas size (HP:0012094)3.27375553
6Cerebral aneurysm (HP:0004944)3.24086185
7Aortic aneurysm (HP:0004942)3.04281703
8Abnormality of the 4th metacarpal (HP:0010012)2.99641929
9Ankle contracture (HP:0006466)2.97659630
10Fair hair (HP:0002286)2.84666049
11Genetic anticipation (HP:0003743)2.82158367
12Premature rupture of membranes (HP:0001788)2.72504904
13Aortic dissection (HP:0002647)2.61652171
14Rectal prolapse (HP:0002035)2.59872084
15Broad metatarsal (HP:0001783)2.57870035
162-3 toe syndactyly (HP:0004691)2.56870786
17Mitral valve prolapse (HP:0001634)2.56785447
18Abnormality of the fingertips (HP:0001211)2.56022613
19Subacute progressive viral hepatitis (HP:0006572)2.45652273
20Hyperventilation (HP:0002883)2.44000731
21Abnormal hair whorl (HP:0010721)2.43361313
22Increased connective tissue (HP:0009025)2.42114234
23Hypoplastic ischia (HP:0003175)2.40430363
24Tubular atrophy (HP:0000092)2.38529315
25Abnormality of the ischium (HP:0003174)2.38310122
26Absent frontal sinuses (HP:0002688)2.36723296
27Dilatation of the ascending aorta (HP:0005111)2.34322870
28Syringomyelia (HP:0003396)2.33858351
29Spinal cord lesions (HP:0100561)2.33858351
30Macroorchidism (HP:0000053)2.33127410
31Increased density of long bones (HP:0006392)2.29924337
32Aplasia cutis congenita (HP:0001057)2.28869839
33Molar tooth sign on MRI (HP:0002419)2.26284181
34Abnormality of midbrain morphology (HP:0002418)2.26284181
35Hematochezia (HP:0002573)2.25094760
36Pancreatic cysts (HP:0001737)2.24481545
37Shawl scrotum (HP:0000049)2.24048476
38Preaxial foot polydactyly (HP:0001841)2.21622384
39Protruding tongue (HP:0010808)2.20041375
40Cutaneous finger syndactyly (HP:0010554)2.18452197
41Aneurysm (HP:0002617)2.14816211
42Urethral obstruction (HP:0000796)2.13072629
43Long nose (HP:0003189)2.11431476
44Abnormality of the renal cortex (HP:0011035)2.11352871
45Abnormality of the renal medulla (HP:0100957)2.10528438
46Atrophic scars (HP:0001075)2.10071478
47Osteolytic defects of the hand bones (HP:0009699)2.09271910
48Osteolytic defects of the phalanges of the hand (HP:0009771)2.09271910
49Narrow palate (HP:0000189)2.09121740
50Cervical subluxation (HP:0003308)2.09071509
51Broad thumb (HP:0011304)2.07611732
52Long eyelashes (HP:0000527)2.06623259
53Selective tooth agenesis (HP:0001592)2.05375103
54Hypoplastic nipples (HP:0002557)2.04528461
55Generalized hypopigmentation of hair (HP:0011358)2.03747302
56Papillary thyroid carcinoma (HP:0002895)2.03027789
57Pancreatic fibrosis (HP:0100732)2.01052799
58Ulnar bowing (HP:0003031)2.00244769
59Short hallux (HP:0010109)1.99988552
60Bladder diverticulum (HP:0000015)1.99845090
61Lymphangioma (HP:0100764)1.99046089
62Curly hair (HP:0002212)1.98576210
63Hypoplastic labia majora (HP:0000059)1.96877264
64Widely spaced teeth (HP:0000687)1.96790202
65Oligodontia (HP:0000677)1.96596563
66Trigonocephaly (HP:0000243)1.95930633
67Congenital sensorineural hearing impairment (HP:0008527)1.94884013
68Abnormality of the distal phalanx of the thumb (HP:0009617)1.94847068
69Spondylolisthesis (HP:0003302)1.94722025
70Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.93217643
71Broad phalanges of the hand (HP:0009768)1.92285751
72Broad long bones (HP:0005622)1.91030295
73Bicuspid aortic valve (HP:0001647)1.90952718
74Metaphyseal cupping (HP:0003021)1.90186018
75Heterotopia (HP:0002282)1.89317108
76Limited elbow extension (HP:0001377)1.89236732
77Tibial bowing (HP:0002982)1.89075273
78Volvulus (HP:0002580)1.87706451
79Milia (HP:0001056)1.87455690
80Abnormality of the astrocytes (HP:0100707)1.86929186
81Astrocytoma (HP:0009592)1.86929186
82Broad phalanx (HP:0006009)1.86188193
83Aplasia/Hypoplasia of the hallux (HP:0008362)1.85452392
84Disproportionate short-trunk short stature (HP:0003521)1.85101002
85Abnormality of the nasal septum (HP:0000419)1.84813719
86Wrist flexion contracture (HP:0001239)1.83302246
87Hyperkalemia (HP:0002153)1.81707708
88Cutaneous syndactyly (HP:0012725)1.80881135
89Lip pit (HP:0100267)1.80788277
90Genu recurvatum (HP:0002816)1.80694147
91Chronic hepatic failure (HP:0100626)1.80652683
92Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.80283024
93Short 1st metacarpal (HP:0010034)1.80283024
94Gastrointestinal carcinoma (HP:0002672)1.80054666
95Malignant gastrointestinal tract tumors (HP:0006749)1.80054666
96Soft skin (HP:0000977)1.79921882
97Deviation of the hallux (HP:0010051)1.79399858
98Deviation of the thumb (HP:0009603)1.78800684
99Bowel diverticulosis (HP:0005222)1.78480369
100Wide intermamillary distance (HP:0006610)1.78327374
101Abnormality of the phalanges of the 2nd finger (HP:0009541)1.77949486
102Progressive cerebellar ataxia (HP:0002073)1.77780996
103Broad finger (HP:0001500)1.77680568
104Nephronophthisis (HP:0000090)1.76077837
105Abnormal biliary tract morphology (HP:0012440)1.75654586
106Hallux valgus (HP:0001822)1.75571811
107Aplasia/Hypoplasia of the tibia (HP:0005772)1.74414853
108High pitched voice (HP:0001620)1.73704873
109Mesomelia (HP:0003027)1.73662356
110Abnormality of the labia majora (HP:0012881)1.73094668
111Dislocated radial head (HP:0003083)1.72016717
112Broad toe (HP:0001837)1.71503884
113Labial hypoplasia (HP:0000066)1.71491774
114Absent eyebrow (HP:0002223)1.70906594
115Midline defect of the nose (HP:0004122)1.70443058
116Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.70318388
117True hermaphroditism (HP:0010459)1.70122150
118Exostoses (HP:0100777)1.70011783
119Gastrointestinal atresia (HP:0002589)1.69635766
120Wormian bones (HP:0002645)1.69469895
121Blue sclerae (HP:0000592)1.69287544
122Renal duplication (HP:0000075)1.69152360
123Right ventricular cardiomyopathy (HP:0011663)1.68562923
124Broad ribs (HP:0000885)1.68481867
125Joint laxity (HP:0001388)1.68263726
126Ectopic kidney (HP:0000086)1.67857462
127Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.67578243
128Chorioretinal atrophy (HP:0000533)1.67418751
129Inability to walk (HP:0002540)1.67275791
130Fibular aplasia (HP:0002990)1.67147448
131Skull defect (HP:0001362)1.66999201
132Biliary tract neoplasm (HP:0100574)1.66609198
133Peritonitis (HP:0002586)1.66599732
134Camptodactyly of toe (HP:0001836)1.65493644
135Hyporeflexia of lower limbs (HP:0002600)1.65439015
136Conical tooth (HP:0000698)1.64186010
137Thin bony cortex (HP:0002753)1.63702211
138Fragile skin (HP:0001030)1.63555909
139Persistence of primary teeth (HP:0006335)1.63468763
140Hypoplasia of dental enamel (HP:0006297)1.62494509
141Arterial tortuosity (HP:0005116)1.62365172
142Keratoconus (HP:0000563)1.62115098
143Increased corneal curvature (HP:0100692)1.62115098
144Radial bowing (HP:0002986)1.62112517
145Cupped ear (HP:0000378)1.60858081
146Alopecia of scalp (HP:0002293)1.60549196
147Abnormality of the radial head (HP:0003995)1.60270016
148Type II lissencephaly (HP:0007260)1.60052451
149Disproportionate tall stature (HP:0001519)1.59900862
150Vascular tortuosity (HP:0004948)1.59601728
151Short phalanx of the thumb (HP:0009660)1.59568146
152Barrel-shaped chest (HP:0001552)1.59342476
153Broad hallux (HP:0010055)1.59178897
154Microtia (HP:0008551)1.59006052
155Abnormal vertebral ossification (HP:0100569)1.58212605
156Hip dysplasia (HP:0001385)1.58147741
157Vertebral arch anomaly (HP:0008438)1.57841455
158Colon cancer (HP:0003003)1.57813065
159Low anterior hairline (HP:0000294)1.56918628
160Gaze-evoked nystagmus (HP:0000640)1.56674334
161Flat face (HP:0012368)1.55958394
162Abnormality of the right ventricle (HP:0001707)1.55832880
163Hypoplastic iliac wings (HP:0002866)1.54924979
164Chromsome breakage (HP:0040012)1.53719852
165Aplasia/Hypoplasia of the uvula (HP:0010293)1.53276607
166Abnormality of chloride homeostasis (HP:0011422)1.53158801
167Progressive inability to walk (HP:0002505)1.51962616
168Intestinal atresia (HP:0011100)1.50695759
169Abnormality of incisor morphology (HP:0011063)1.50012331
170Esophageal atresia (HP:0002032)1.49726662
171Increased number of teeth (HP:0011069)1.49464795
172Abnormality of chromosome stability (HP:0003220)1.49323101
173Neonatal short-limb short stature (HP:0008921)1.49027468
174Cystic hygroma (HP:0000476)1.48123136
175Morphological abnormality of the middle ear (HP:0008609)1.48103373
176Tapered finger (HP:0001182)1.47598937
177Polydipsia (HP:0001959)1.46848323
178Abnormal drinking behavior (HP:0030082)1.46848323
179Abnormality of the pubic bones (HP:0003172)1.46114443
180Aplasia/Hypoplasia of metatarsal bones (HP:0001964)1.45464419
181Bilateral microphthalmos (HP:0007633)1.45170653
182Abnormality of the nasolacrimal system (HP:0000614)1.44990362
183Abnormality of the pons (HP:0007361)1.44311094
184Rectal fistula (HP:0100590)1.43388212

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK4.99137348
2CDK124.01292899
3TRIB33.51156793
4LATS13.13602064
5MAP3K102.92653757
6BMPR1B2.91962048
7TTN2.83961266
8ACVR1B2.68138407
9PDGFRA2.42540445
10AKT32.39144901
11PKN22.15268907
12CAMK1D2.11581841
13CASK2.10071106
14SIK12.07894906
15RIPK12.06318842
16DDR22.03964175
17STK31.99907389
18PTK61.90945327
19SGK21.85182480
20TNIK1.81961144
21MKNK21.76813529
22EEF2K1.69419958
23STK101.61079431
24STK391.58802582
25FRK1.52493045
26CAMK1G1.50088944
27DMPK1.49724196
28TGFBR21.47217992
29ICK1.46467324
30MTOR1.45561803
31PDGFRB1.43191448
32EPHB21.42765741
33FGFR31.34902260
34NEK21.34722120
35CDK61.33011092
36RPS6KA41.32462423
37ADRBK21.27729599
38CDC71.24819137
39FGFR21.21674760
40TGFBR11.21121757
41LMTK21.20522324
42NLK1.12130121
43GRK11.09952941
44CHUK1.09223136
45WNK41.05723335
46BRD41.04998037
47MELK1.04378813
48SCYL21.03179005
49CDK91.02827461
50WNK31.02635283
51PAK21.01344259
52TAF11.00867229
53SGK2230.99090144
54SGK4940.99090144
55FGFR40.98249110
56TIE10.98088778
57JAK10.96823676
58NUAK10.96683639
59OXSR10.96458878
60BRSK20.95689626
61FGFR10.95151609
62PIK3CG0.94489632
63TRPM70.91065714
64PAK40.90009270
65LRRK20.87533738
66DYRK1B0.87511202
67PRKCE0.86805538
68PDK30.85490923
69PDK40.85490923
70EPHA30.84714535
71FLT30.84666176
72STK40.84550758
73ZAK0.84500040
74RPS6KB20.82946751
75MARK30.81557723
76PTK20.81367392
77BMX0.80802489
78MST1R0.80499900
79TAOK30.78888721
80CDK40.78251065
81MAP3K90.78222284
82NEK90.78088520
83MET0.74824369
84TYK20.74309826
85PAK30.74290867
86TYRO30.73935229
87ERN10.73486048
88ADRBK10.73168809
89JAK30.71647573
90FER0.71403893
91MAP3K140.71132503
92MAP3K30.70709988
93MKNK10.70499103
94ERBB30.69924549
95ATM0.68470752
96BCR0.67993956
97MAP3K80.67565139
98INSRR0.67467864
99STK240.67029830
100ATR0.66145327
101MAP3K20.64692948
102CHEK10.64536424
103PRKD30.64131206
104PIM10.62888798
105CDK70.62433894
106RPS6KA60.61590619
107IKBKB0.61478799
108RPS6KA20.60512515
109MST40.58607097
110EPHA20.57842205
111SGK30.57709522
112PIK3CA0.57451357
113CDK30.57053691
114STK38L0.56926637
115PINK10.54837312
116ERBB40.54740476
117TTK0.54178964
118ERBB20.53755000
119MAP2K30.52764244
120RPS6KB10.52470767
121CSK0.50195328
122PASK0.49994910
123OBSCN0.49806951
124EIF2AK30.48935016
125AURKB0.48499659
126MAP3K70.47438027
127GSK3A0.47372067
128WNK10.47282967
129IRAK10.46821923
130MAPK10.45417905
131GRK70.45319475
132TESK10.44545348
133LATS20.44274659
134MAP2K10.44058502
135INSR0.42972101
136RPS6KC10.42914020
137RPS6KL10.42914020
138TLK10.42775277
139CDC42BPA0.41667036
140MAPK70.41463195
141AKT10.40929058
142PDK20.40665024
143ROCK10.39172033
144CDK20.38616653
145PRKAA20.38518213
146ABL10.38163893
147RET0.37442354
148SGK10.37406390
149ILK0.37229438
150TBK10.37072201
151EPHB10.36481666
152CSF1R0.36431592
153IGF1R0.35523018
154PRKD10.35126441
155EIF2AK20.34150912
156PLK40.33810257
157PRKCZ0.32952728
158CDK80.32914965
159STK380.32370433
160PRKAA10.31613907

Predicted pathways (KEGG)

RankGene SetZ-score
1Adherens junction_Homo sapiens_hsa045202.32305737
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.31780649
3ECM-receptor interaction_Homo sapiens_hsa045122.29573893
4Small cell lung cancer_Homo sapiens_hsa052222.08746203
5Focal adhesion_Homo sapiens_hsa045101.97395219
6Viral myocarditis_Homo sapiens_hsa054161.90008798
7Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.82209311
8MicroRNAs in cancer_Homo sapiens_hsa052061.77466497
9Chronic myeloid leukemia_Homo sapiens_hsa052201.76199613
10Proteoglycans in cancer_Homo sapiens_hsa052051.75673698
11Lysine degradation_Homo sapiens_hsa003101.72913974
12Maturity onset diabetes of the young_Homo sapiens_hsa049501.66649282
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.64280983
14Dorso-ventral axis formation_Homo sapiens_hsa043201.54808006
15Basal cell carcinoma_Homo sapiens_hsa052171.53771919
16TGF-beta signaling pathway_Homo sapiens_hsa043501.53650051
17AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.50964359
18Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.49245501
19Basal transcription factors_Homo sapiens_hsa030221.49132826
20Toxoplasmosis_Homo sapiens_hsa051451.47782827
21Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.42968227
22Hippo signaling pathway_Homo sapiens_hsa043901.42899096
23HTLV-I infection_Homo sapiens_hsa051661.36058923
24Amoebiasis_Homo sapiens_hsa051461.35462359
25Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.30999317
26Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.30327060
27Prostate cancer_Homo sapiens_hsa052151.27170824
28mTOR signaling pathway_Homo sapiens_hsa041501.23296763
29Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.23063497
30Notch signaling pathway_Homo sapiens_hsa043301.22815010
31Insulin resistance_Homo sapiens_hsa049311.22527116
32Circadian rhythm_Homo sapiens_hsa047101.22373375
33Pancreatic cancer_Homo sapiens_hsa052121.22157052
34Viral carcinogenesis_Homo sapiens_hsa052031.21553523
35Fanconi anemia pathway_Homo sapiens_hsa034601.18107427
36Thyroid hormone signaling pathway_Homo sapiens_hsa049191.17980622
37Endometrial cancer_Homo sapiens_hsa052131.17264913
38TNF signaling pathway_Homo sapiens_hsa046681.17228453
39ABC transporters_Homo sapiens_hsa020101.17133625
40NF-kappa B signaling pathway_Homo sapiens_hsa040641.16941317
41Leishmaniasis_Homo sapiens_hsa051401.16709492
42Transcriptional misregulation in cancer_Homo sapiens_hsa052021.16321275
43Dilated cardiomyopathy_Homo sapiens_hsa054141.15410348
44Cell cycle_Homo sapiens_hsa041101.14052307
45Colorectal cancer_Homo sapiens_hsa052101.13699596
46Leukocyte transendothelial migration_Homo sapiens_hsa046701.13592730
47Axon guidance_Homo sapiens_hsa043601.12934865
48Malaria_Homo sapiens_hsa051441.11142976
49Herpes simplex infection_Homo sapiens_hsa051681.09785999
50Osteoclast differentiation_Homo sapiens_hsa043801.08081541
51Hepatitis B_Homo sapiens_hsa051611.07921565
52Nitrogen metabolism_Homo sapiens_hsa009101.07771756
53p53 signaling pathway_Homo sapiens_hsa041151.07394290
54Pathways in cancer_Homo sapiens_hsa052001.06098759
55Non-homologous end-joining_Homo sapiens_hsa034501.03358740
56Caffeine metabolism_Homo sapiens_hsa002321.02627050
57Ether lipid metabolism_Homo sapiens_hsa005651.01809325
58Measles_Homo sapiens_hsa051621.01177421
59Systemic lupus erythematosus_Homo sapiens_hsa053220.99939939
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.99056658
61Protein digestion and absorption_Homo sapiens_hsa049740.98961599
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.98733255
63Selenocompound metabolism_Homo sapiens_hsa004500.98020076
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.96251996
65Central carbon metabolism in cancer_Homo sapiens_hsa052300.95955951
66Linoleic acid metabolism_Homo sapiens_hsa005910.95800698
67Hedgehog signaling pathway_Homo sapiens_hsa043400.94728843
68Sphingolipid metabolism_Homo sapiens_hsa006000.94639011
69Influenza A_Homo sapiens_hsa051640.94528048
70Antigen processing and presentation_Homo sapiens_hsa046120.92651640
71Regulation of actin cytoskeleton_Homo sapiens_hsa048100.91280464
72Apoptosis_Homo sapiens_hsa042100.91089734
73Platelet activation_Homo sapiens_hsa046110.90976373
74Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.90934421
75PI3K-Akt signaling pathway_Homo sapiens_hsa041510.90568524
76Acute myeloid leukemia_Homo sapiens_hsa052210.89650834
77Phototransduction_Homo sapiens_hsa047440.89464029
78Legionellosis_Homo sapiens_hsa051340.88690469
79FoxO signaling pathway_Homo sapiens_hsa040680.88067097
80Bladder cancer_Homo sapiens_hsa052190.88016671
81B cell receptor signaling pathway_Homo sapiens_hsa046620.87765672
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.86308608
83Protein export_Homo sapiens_hsa030600.85019806
84Jak-STAT signaling pathway_Homo sapiens_hsa046300.84982675
85Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.84951822
86Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.84047284
87Renal cell carcinoma_Homo sapiens_hsa052110.83700065
88Tryptophan metabolism_Homo sapiens_hsa003800.83621859
89Wnt signaling pathway_Homo sapiens_hsa043100.82862328
90ErbB signaling pathway_Homo sapiens_hsa040120.82654426
91Tight junction_Homo sapiens_hsa045300.82516332
92Ovarian steroidogenesis_Homo sapiens_hsa049130.79481243
93Non-small cell lung cancer_Homo sapiens_hsa052230.79416437
94Toll-like receptor signaling pathway_Homo sapiens_hsa046200.78971391
95mRNA surveillance pathway_Homo sapiens_hsa030150.78752566
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.78672806
97AMPK signaling pathway_Homo sapiens_hsa041520.78412657
98Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77034984
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76324040
100T cell receptor signaling pathway_Homo sapiens_hsa046600.76117318
101Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75803679
102Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.74157393
103Fatty acid biosynthesis_Homo sapiens_hsa000610.73553366
104Glioma_Homo sapiens_hsa052140.73354275
105Vitamin digestion and absorption_Homo sapiens_hsa049770.73184132
106Melanoma_Homo sapiens_hsa052180.72855045
107Prolactin signaling pathway_Homo sapiens_hsa049170.72206716
108Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.70394817
109Thyroid cancer_Homo sapiens_hsa052160.69954794
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.68771032
111NOD-like receptor signaling pathway_Homo sapiens_hsa046210.68429804
112Hepatitis C_Homo sapiens_hsa051600.67846183
113Vascular smooth muscle contraction_Homo sapiens_hsa042700.67520440
114Glucagon signaling pathway_Homo sapiens_hsa049220.67424079
115RNA transport_Homo sapiens_hsa030130.67249065
116Type II diabetes mellitus_Homo sapiens_hsa049300.65206964
117Rap1 signaling pathway_Homo sapiens_hsa040150.65044728
118One carbon pool by folate_Homo sapiens_hsa006700.64468090
119cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64082230
120HIF-1 signaling pathway_Homo sapiens_hsa040660.63994069
121Insulin signaling pathway_Homo sapiens_hsa049100.63614444
122Hematopoietic cell lineage_Homo sapiens_hsa046400.63503836
123Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63238282
124Sulfur metabolism_Homo sapiens_hsa009200.62981469
125Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62876167
126Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62814000
127MAPK signaling pathway_Homo sapiens_hsa040100.61266213
128Shigellosis_Homo sapiens_hsa051310.61025447
129Salmonella infection_Homo sapiens_hsa051320.60886524
130Steroid hormone biosynthesis_Homo sapiens_hsa001400.60702083
131Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59761812
132Estrogen signaling pathway_Homo sapiens_hsa049150.59088872
133Renin-angiotensin system_Homo sapiens_hsa046140.57294369
134Ras signaling pathway_Homo sapiens_hsa040140.55178216
135Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54571094
136African trypanosomiasis_Homo sapiens_hsa051430.54128636
137Mineral absorption_Homo sapiens_hsa049780.52888970
138VEGF signaling pathway_Homo sapiens_hsa043700.51963157
139Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51062378
140Homologous recombination_Homo sapiens_hsa034400.49266826
141Gap junction_Homo sapiens_hsa045400.47161799
142Serotonergic synapse_Homo sapiens_hsa047260.46340430
143Long-term depression_Homo sapiens_hsa047300.46094403
144Retinol metabolism_Homo sapiens_hsa008300.45090641
145Choline metabolism in cancer_Homo sapiens_hsa052310.44580617
146Calcium signaling pathway_Homo sapiens_hsa040200.43984617
147Butanoate metabolism_Homo sapiens_hsa006500.43438409
148Thyroid hormone synthesis_Homo sapiens_hsa049180.43434780

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