BTBD7P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)7.33003431
2membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.44113579
3membrane repolarization during cardiac muscle cell action potential (GO:0086013)4.37438642
4sulfation (GO:0051923)4.16349866
5indolalkylamine metabolic process (GO:0006586)4.11702027
6water-soluble vitamin biosynthetic process (GO:0042364)4.07904026
7membrane repolarization during action potential (GO:0086011)3.99796256
8kynurenine metabolic process (GO:0070189)3.80767525
9mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.75314226
10mitochondrial respiratory chain complex I assembly (GO:0032981)3.75314226
11NADH dehydrogenase complex assembly (GO:0010257)3.75314226
12indole-containing compound catabolic process (GO:0042436)3.75134859
13indolalkylamine catabolic process (GO:0046218)3.75134859
14tryptophan catabolic process (GO:0006569)3.75134859
15cell proliferation in forebrain (GO:0021846)3.74255997
16DNA deamination (GO:0045006)3.74168803
17regulation of mesoderm development (GO:2000380)3.69745639
18somite development (GO:0061053)3.69038214
19protein complex biogenesis (GO:0070271)3.67946590
20gamma-aminobutyric acid transport (GO:0015812)3.66005954
21negative regulation of transcription regulatory region DNA binding (GO:2000678)3.61303181
22L-fucose catabolic process (GO:0042355)3.58501489
23fucose catabolic process (GO:0019317)3.58501489
24L-fucose metabolic process (GO:0042354)3.58501489
25serotonin metabolic process (GO:0042428)3.55602600
26primary amino compound metabolic process (GO:1901160)3.46181422
27protein polyglutamylation (GO:0018095)3.41511389
28transmission of nerve impulse (GO:0019226)3.32740703
29indole-containing compound metabolic process (GO:0042430)3.30218250
30mitochondrial respiratory chain complex assembly (GO:0033108)3.28388998
31negative regulation of appetite (GO:0032099)3.27153676
32negative regulation of response to food (GO:0032096)3.27153676
33epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.21950311
34establishment of protein localization to mitochondrial membrane (GO:0090151)3.11595087
35membrane repolarization (GO:0086009)3.04809449
36epithelial cilium movement (GO:0003351)3.03867593
37energy coupled proton transport, down electrochemical gradient (GO:0015985)3.03763078
38ATP synthesis coupled proton transport (GO:0015986)3.03763078
39tryptophan metabolic process (GO:0006568)3.03408853
40negative regulation of synaptic transmission, GABAergic (GO:0032229)3.01739429
41parturition (GO:0007567)2.95455514
42mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.93656317
43mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.92953092
44cellular response to ATP (GO:0071318)2.90581244
45positive regulation of fatty acid beta-oxidation (GO:0032000)2.83226855
46negative regulation of mast cell activation (GO:0033004)2.82154282
47positive regulation of fatty acid oxidation (GO:0046321)2.80331069
48regulation of action potential (GO:0098900)2.79553649
49spinal cord motor neuron differentiation (GO:0021522)2.79172287
50kidney morphogenesis (GO:0060993)2.78315616
51regulation of membrane repolarization (GO:0060306)2.75919614
52positive regulation of potassium ion transmembrane transport (GO:1901381)2.74768473
53detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.73209603
54endoderm formation (GO:0001706)2.73039409
55regulation of rhodopsin mediated signaling pathway (GO:0022400)2.71932393
56regulation of glomerulus development (GO:0090192)2.70775199
57synaptic transmission, cholinergic (GO:0007271)2.70502905
58platelet dense granule organization (GO:0060155)2.68793635
59axoneme assembly (GO:0035082)2.65370405
60regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.62513612
61detection of light stimulus involved in sensory perception (GO:0050962)2.62030699
62detection of light stimulus involved in visual perception (GO:0050908)2.62030699
63negative regulation of systemic arterial blood pressure (GO:0003085)2.61726766
64membrane depolarization during action potential (GO:0086010)2.60295591
65rhodopsin mediated signaling pathway (GO:0016056)2.58176931
66neuronal action potential (GO:0019228)2.57766660
67ovulation cycle (GO:0042698)2.57260990
683-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.55644172
69purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.55644172
70nonmotile primary cilium assembly (GO:0035058)2.53473561
71magnesium ion transport (GO:0015693)2.51877245
72cilium movement (GO:0003341)2.51708464
73multicellular organismal signaling (GO:0035637)2.50975191
74regulation of posttranscriptional gene silencing (GO:0060147)2.50628930
75regulation of gene silencing by miRNA (GO:0060964)2.50628930
76regulation of gene silencing by RNA (GO:0060966)2.50628930
77positive regulation of fatty acid transport (GO:2000193)2.50398604
78adaptation of signaling pathway (GO:0023058)2.50132630
79negative regulation of astrocyte differentiation (GO:0048712)2.49815333
80negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.48286611
81cellular anion homeostasis (GO:0030002)2.47657007
82cellular response to exogenous dsRNA (GO:0071360)2.47599219
83otic vesicle formation (GO:0030916)2.46177343
84negative regulation by host of viral transcription (GO:0043922)2.45162997
85negative regulation of telomere maintenance (GO:0032205)2.45100669
86G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.44155561
87positive regulation of defense response to virus by host (GO:0002230)2.43712460
88protein neddylation (GO:0045116)2.40767992
89amine catabolic process (GO:0009310)2.40471249
90cellular biogenic amine catabolic process (GO:0042402)2.40471249
91regulation of sequestering of triglyceride (GO:0010889)2.40064448
92regulation of hippo signaling (GO:0035330)2.39855180
93positive regulation of oligodendrocyte differentiation (GO:0048714)2.38735108
94electron transport chain (GO:0022900)2.38477204
95DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.37566379
96cell differentiation in spinal cord (GO:0021515)2.36892371
97nephron tubule morphogenesis (GO:0072078)2.36337323
98nephron epithelium morphogenesis (GO:0072088)2.36337323
99retinal ganglion cell axon guidance (GO:0031290)2.35185669
100negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.34401504

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.01691938
2ZNF274_21170338_ChIP-Seq_K562_Hela3.08996415
3VDR_22108803_ChIP-Seq_LS180_Human3.08975623
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.70480479
5GBX2_23144817_ChIP-Seq_PC3_Human2.68034765
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.50043715
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.31311374
8BMI1_23680149_ChIP-Seq_NPCS_Mouse2.28527782
9EED_16625203_ChIP-ChIP_MESCs_Mouse2.22944579
10RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.21112892
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.13473581
12CBX2_27304074_Chip-Seq_ESCs_Mouse2.11376577
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.04562236
14JARID2_20064375_ChIP-Seq_MESCs_Mouse1.99979059
15IRF1_19129219_ChIP-ChIP_H3396_Human1.95799100
16CTBP1_25329375_ChIP-Seq_LNCAP_Human1.93489488
17CTBP2_25329375_ChIP-Seq_LNCAP_Human1.91685994
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.85237743
19EWS_26573619_Chip-Seq_HEK293_Human1.80555056
20SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.76351959
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.75413298
22JARID2_20075857_ChIP-Seq_MESCs_Mouse1.75303344
23REST_21632747_ChIP-Seq_MESCs_Mouse1.75114527
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73572109
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.68983777
26TAF15_26573619_Chip-Seq_HEK293_Human1.68316810
27FUS_26573619_Chip-Seq_HEK293_Human1.67653433
28RNF2_27304074_Chip-Seq_NSC_Mouse1.66610248
29SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.65691125
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.65373816
31IGF1R_20145208_ChIP-Seq_DFB_Human1.64961326
32P300_19829295_ChIP-Seq_ESCs_Human1.64605801
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.64082411
34EZH2_27294783_Chip-Seq_ESCs_Mouse1.63894080
35EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.62865331
36SUZ12_27294783_Chip-Seq_ESCs_Mouse1.60378350
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.54594090
38MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.49571305
39RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.44620118
40SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.44552937
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.42501037
42SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.42427884
43ER_23166858_ChIP-Seq_MCF-7_Human1.40623271
44UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40177934
45EZH2_18974828_ChIP-Seq_MESCs_Mouse1.38966989
46RNF2_18974828_ChIP-Seq_MESCs_Mouse1.38966989
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.38249089
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36654039
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36316965
50CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.35004812
51NR3C1_21868756_ChIP-Seq_MCF10A_Human1.31508167
52MYC_18940864_ChIP-ChIP_HL60_Human1.31208560
53TP53_22573176_ChIP-Seq_HFKS_Human1.29755951
54BCAT_22108803_ChIP-Seq_LS180_Human1.27646257
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.27099932
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26189994
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25862497
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25213194
59CBP_20019798_ChIP-Seq_JUKART_Human1.25213194
60GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23533414
61FOXA1_25329375_ChIP-Seq_VCAP_Human1.20795960
62FOXA1_27270436_Chip-Seq_PROSTATE_Human1.20795960
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20731886
64STAT3_23295773_ChIP-Seq_U87_Human1.19817146
65AR_25329375_ChIP-Seq_VCAP_Human1.19790574
66TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19405231
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19405231
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.19146793
69NCOR_22424771_ChIP-Seq_293T_Human1.18411863
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16853730
71SMAD4_21799915_ChIP-Seq_A2780_Human1.16721979
72SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.16166515
73GABP_17652178_ChIP-ChIP_JURKAT_Human1.15259484
74GATA3_21878914_ChIP-Seq_MCF-7_Human1.14616317
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.14526257
76AUTS2_25519132_ChIP-Seq_293T-REX_Human1.14401872
77NANOG_19829295_ChIP-Seq_ESCs_Human1.13785690
78SOX2_19829295_ChIP-Seq_ESCs_Human1.13785690
79TCF4_23295773_ChIP-Seq_U87_Human1.12981689
80REST_18959480_ChIP-ChIP_MESCs_Mouse1.12771827
81MTF2_20144788_ChIP-Seq_MESCs_Mouse1.12189844
82POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11594106
83ETV2_25802403_ChIP-Seq_MESCs_Mouse1.10747968
84MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09949393
85PRDM14_20953172_ChIP-Seq_ESCs_Human1.07624691
86SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.06330051
87PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04075571
88SMAD4_21741376_ChIP-Seq_EPCs_Human1.03094588
89TP53_20018659_ChIP-ChIP_R1E_Mouse1.03060758
90AR_20517297_ChIP-Seq_VCAP_Human1.01419303
91TDRD3_21172665_ChIP-Seq_MCF-7_Human1.01250080
92TAF2_19829295_ChIP-Seq_ESCs_Human1.01167780
93SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99578831
94PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98731764
95TCF4_22108803_ChIP-Seq_LS180_Human0.98105641
96NFE2_27457419_Chip-Seq_LIVER_Mouse0.97237895
97KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.97219281
98RUNX2_22187159_ChIP-Seq_PCA_Human0.96371356
99CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.96009117
100TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.94832165

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode2.94257801
2MP0003646_muscle_fatigue2.92836601
3MP0004885_abnormal_endolymph2.68961454
4MP0001485_abnormal_pinna_reflex2.56881242
5MP0002837_dystrophic_cardiac_calcinosis2.52511261
6MP0005646_abnormal_pituitary_gland2.42696341
7MP0001968_abnormal_touch/_nociception2.24133062
8MP0003136_yellow_coat_color2.15629371
9MP0003195_calcinosis2.10572716
10MP0002102_abnormal_ear_morphology2.08022768
11MP0004145_abnormal_muscle_electrophysio2.02085338
12MP0005551_abnormal_eye_electrophysiolog1.99991873
13MP0000569_abnormal_digit_pigmentation1.95727419
14MP0006072_abnormal_retinal_apoptosis1.92889878
15MP0009379_abnormal_foot_pigmentation1.91450802
16MP0002736_abnormal_nociception_after1.90975681
17MP0009745_abnormal_behavioral_response1.89597290
18MP0002876_abnormal_thyroid_physiology1.88689161
19MP0003011_delayed_dark_adaptation1.87871379
20MP0004142_abnormal_muscle_tone1.83159692
21MP0002272_abnormal_nervous_system1.81171576
22MP0000631_abnormal_neuroendocrine_gland1.80940839
23MP0005377_hearing/vestibular/ear_phenot1.78488657
24MP0003878_abnormal_ear_physiology1.78488657
25MP0002160_abnormal_reproductive_system1.78328471
26MP0008877_abnormal_DNA_methylation1.77473483
27MP0002653_abnormal_ependyma_morphology1.70896420
28MP0003283_abnormal_digestive_organ1.70678298
29MP0004742_abnormal_vestibular_system1.69915304
30MP0004130_abnormal_muscle_cell1.68089475
31MP0004133_heterotaxia1.65808459
32MP0008872_abnormal_physiological_respon1.59769230
33MP0003880_abnormal_central_pattern1.56706559
34MP0000049_abnormal_middle_ear1.56557765
35MP0002938_white_spotting1.55696323
36MP0009046_muscle_twitch1.52562967
37MP0005389_reproductive_system_phenotype1.52425517
38MP0002735_abnormal_chemical_nociception1.52403505
39MP0001486_abnormal_startle_reflex1.49092319
40MP0002638_abnormal_pupillary_reflex1.46267866
41MP0006276_abnormal_autonomic_nervous1.44861533
42MP0000026_abnormal_inner_ear1.44120653
43MP0002733_abnormal_thermal_nociception1.41467382
44MP0001440_abnormal_grooming_behavior1.40987408
45MP0002064_seizures1.38923164
46MP0005253_abnormal_eye_physiology1.35023583
47MP0005084_abnormal_gallbladder_morpholo1.33760696
48MP0003879_abnormal_hair_cell1.33590802
49MP0001970_abnormal_pain_threshold1.29793319
50MP0001986_abnormal_taste_sensitivity1.26766318
51MP0002572_abnormal_emotion/affect_behav1.26010642
52MP0002557_abnormal_social/conspecific_i1.24631601
53MP0008875_abnormal_xenobiotic_pharmacok1.24282746
54MP0001905_abnormal_dopamine_level1.23596517
55MP0001963_abnormal_hearing_physiology1.22096344
56MP0001919_abnormal_reproductive_system1.21744393
57MP0003119_abnormal_digestive_system1.21322616
58MP0002277_abnormal_respiratory_mucosa1.20885867
59MP0003938_abnormal_ear_development1.19378052
60MP0003787_abnormal_imprinting1.18568413
61MP0008775_abnormal_heart_ventricle1.16950302
62MP0009053_abnormal_anal_canal1.15269181
63MP0002928_abnormal_bile_duct1.13711301
64MP0003635_abnormal_synaptic_transmissio1.11054734
65MP0004215_abnormal_myocardial_fiber1.08555550
66MP0002734_abnormal_mechanical_nocicepti1.08555505
67MP0005174_abnormal_tail_pigmentation1.07354393
68MP0001501_abnormal_sleep_pattern1.06849859
69MP0008789_abnormal_olfactory_epithelium1.06441287
70MP0002063_abnormal_learning/memory/cond1.05594621
71MP0005195_abnormal_posterior_eye1.04676976
72MP0005423_abnormal_somatic_nervous1.04362579
73MP0002752_abnormal_somatic_nervous1.03614050
74MP0000230_abnormal_systemic_arterial1.03259529
75MP0002067_abnormal_sensory_capabilities1.02902668
76MP0002138_abnormal_hepatobiliary_system1.02821930
77MP0003137_abnormal_impulse_conducting1.02094606
78MP0010386_abnormal_urinary_bladder1.00779738
79MP0005645_abnormal_hypothalamus_physiol0.98784594
80MP0003638_abnormal_response/metabolism_0.97322318
81MP0003937_abnormal_limbs/digits/tail_de0.96726585
82MP0005386_behavior/neurological_phenoty0.95921146
83MP0004924_abnormal_behavior0.95921146
84MP0002184_abnormal_innervation0.95072335
85MP0000778_abnormal_nervous_system0.95056211
86MP0001293_anophthalmia0.90418351
87MP0001529_abnormal_vocalization0.89572132
88MP0009250_abnormal_appendicular_skeleto0.89283011
89MP0002234_abnormal_pharynx_morphology0.88983301
90MP0002163_abnormal_gland_morphology0.87579301
91MP0000383_abnormal_hair_follicle0.86718586
92MP0005671_abnormal_response_to0.86438300
93MP0002282_abnormal_trachea_morphology0.82614577
94MP0008995_early_reproductive_senescence0.82420510
95MP0000427_abnormal_hair_cycle0.81228825
96MP0000372_irregular_coat_pigmentation0.80109033
97MP0005410_abnormal_fertilization0.73341112
98MP0004085_abnormal_heartbeat0.73025122
99MP0001765_abnormal_ion_homeostasis0.72148111
100MP0002229_neurodegeneration0.71095655

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.14683870
2Pancreatic fibrosis (HP:0100732)3.83257716
3True hermaphroditism (HP:0010459)3.74915207
4Congenital, generalized hypertrichosis (HP:0004540)3.63413717
5Congenital stationary night blindness (HP:0007642)3.62919260
6Molar tooth sign on MRI (HP:0002419)3.50381716
7Abnormality of midbrain morphology (HP:0002418)3.50381716
8Nephronophthisis (HP:0000090)3.37895012
9Abolished electroretinogram (ERG) (HP:0000550)3.28558856
10Decreased circulating renin level (HP:0003351)2.99663005
11Abnormality of the renal cortex (HP:0011035)2.96013889
12Pendular nystagmus (HP:0012043)2.90784610
13Abnormality of the renal medulla (HP:0100957)2.87281201
14Aplasia/Hypoplasia of the tibia (HP:0005772)2.69106424
15Concave nail (HP:0001598)2.68595724
16Progressive cerebellar ataxia (HP:0002073)2.65118473
17Type II lissencephaly (HP:0007260)2.58984788
18Absent rod-and cone-mediated responses on ERG (HP:0007688)2.57975895
19Cystic liver disease (HP:0006706)2.56593898
20Decreased electroretinogram (ERG) amplitude (HP:0000654)2.55129655
21Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.52959074
22Abnormality of alanine metabolism (HP:0010916)2.52959074
23Hyperalaninemia (HP:0003348)2.52959074
24Attenuation of retinal blood vessels (HP:0007843)2.50924828
25Agitation (HP:0000713)2.48766227
26Increased corneal curvature (HP:0100692)2.47136455
27Keratoconus (HP:0000563)2.47136455
28Sclerocornea (HP:0000647)2.43930480
29Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.43440032
30Genetic anticipation (HP:0003743)2.42476259
31Short hallux (HP:0010109)2.41013901
32Short tibia (HP:0005736)2.40658734
33Dynein arm defect of respiratory motile cilia (HP:0012255)2.40447240
34Absent/shortened dynein arms (HP:0200106)2.40447240
35Aplasia/Hypoplasia of the spleen (HP:0010451)2.38017602
36Abnormal rod and cone electroretinograms (HP:0008323)2.37464487
37Decreased central vision (HP:0007663)2.35752232
38Asplenia (HP:0001746)2.35697206
39Renal cortical cysts (HP:0000803)2.35325269
40Clumsiness (HP:0002312)2.34748133
41Aplasia/Hypoplasia of the hallux (HP:0008362)2.33519311
42Medial flaring of the eyebrow (HP:0010747)2.33506745
43Furrowed tongue (HP:0000221)2.33175028
44Abnormality of the phalanges of the 2nd finger (HP:0009541)2.32528015
45Abnormal number of erythroid precursors (HP:0012131)2.32474196
46Aplasia/Hypoplasia of the patella (HP:0006498)2.30894020
47Abnormality of the proximal phalanges of the hand (HP:0009834)2.30438240
48Abnormality of the phalanges of the 5th finger (HP:0004213)2.30384333
49Methylmalonic acidemia (HP:0002912)2.29983160
50Symphalangism affecting the phalanges of the hand (HP:0009773)2.28365846
51Abnormality of the middle phalanges of the toes (HP:0010183)2.27638552
523-Methylglutaconic aciduria (HP:0003535)2.25123085
53Tubular atrophy (HP:0000092)2.23582336
54Abnormal respiratory epithelium morphology (HP:0012253)2.21921660
55Abnormal respiratory motile cilium morphology (HP:0005938)2.21921660
56Congenital sensorineural hearing impairment (HP:0008527)2.21824799
57Acute necrotizing encephalopathy (HP:0006965)2.19471248
58Patellar aplasia (HP:0006443)2.18579557
59Metabolic alkalosis (HP:0200114)2.17632835
60Abnormal ciliary motility (HP:0012262)2.15566992
61Abnormality of cells of the erythroid lineage (HP:0012130)2.13580590
62Mitochondrial inheritance (HP:0001427)2.11920966
63Septo-optic dysplasia (HP:0100842)2.11789666
64Bilateral microphthalmos (HP:0007633)2.08451111
65Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.07733334
66Chorioretinal atrophy (HP:0000533)2.07503441
67Aplasia/hypoplasia of the uterus (HP:0008684)2.07215990
68Anencephaly (HP:0002323)2.05710709
69Male pseudohermaphroditism (HP:0000037)2.04623151
70Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.03971263
71Short 4th metacarpal (HP:0010044)2.03971263
72Optic nerve hypoplasia (HP:0000609)2.02418387
73Hypoplasia of the uterus (HP:0000013)2.00170053
74Polydipsia (HP:0001959)1.99631818
75Abnormal drinking behavior (HP:0030082)1.99631818
76Chronic hepatic failure (HP:0100626)1.99304719
77Methylmalonic aciduria (HP:0012120)1.98993911
78Bony spicule pigmentary retinopathy (HP:0007737)1.98460359
79Short femoral neck (HP:0100864)1.97885549
80Optic disc pallor (HP:0000543)1.94475225
81Aplasia/Hypoplasia of the fibula (HP:0006492)1.94276704
82Morphological abnormality of the middle ear (HP:0008609)1.92937711
83Mesomelia (HP:0003027)1.91152461
84Congenital hepatic fibrosis (HP:0002612)1.91135394
85Hypoplasia of the ulna (HP:0003022)1.91008185
86Increased CSF lactate (HP:0002490)1.90388059
87Progressive macrocephaly (HP:0004481)1.90272027
88Abnormal respiratory motile cilium physiology (HP:0012261)1.89581275
89Hyperglycinemia (HP:0002154)1.88514047
90Abnormal mitochondria in muscle tissue (HP:0008316)1.88328711
91Large for gestational age (HP:0001520)1.86845649
92Inability to walk (HP:0002540)1.86127987
93Abnormality of the 4th metacarpal (HP:0010012)1.85878778
94Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.85784901
95Fibular aplasia (HP:0002990)1.85170709
96Acute encephalopathy (HP:0006846)1.84950701
97Abnormality of the renal collecting system (HP:0004742)1.84853497
98Thyroid-stimulating hormone excess (HP:0002925)1.83216656
99Aplasia/Hypoplasia of the tongue (HP:0010295)1.82399801
100Fibular hypoplasia (HP:0003038)1.79814661

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.09782748
2ADRBK23.59846570
3GRK13.25447581
4TLK13.02652369
5BMPR1B2.70865476
6TAOK32.60313799
7INSRR2.55759246
8PINK12.38001215
9ZAK2.34430366
10WNK42.26995580
11ACVR1B1.98222297
12MAP4K21.97072012
13TXK1.94642227
14WNK31.92261048
15NUAK11.81780343
16MAPK151.75023560
17MAPK131.66268303
18PNCK1.58983046
19CASK1.57805761
20ADRBK11.42113401
21STK391.35274091
22DYRK21.32727211
23OXSR11.31582292
24TIE11.30736795
25VRK11.28350203
26VRK21.27942260
27NTRK21.19144945
28PRKCG1.15515937
29BCKDK1.13897814
30DAPK21.11209870
31NTRK31.09826480
32GRK71.09285337
33MAP3K41.04665136
34PIK3CA1.03533410
35TGFBR11.02907602
36MARK11.00396391
37STK160.97188534
38MUSK0.97157988
39KIT0.97055496
40CAMKK20.92871574
41TNIK0.89191412
42TEC0.85313548
43MAP2K20.83645804
44IKBKB0.80468934
45PHKG20.79656815
46PHKG10.79656815
47MAPKAPK50.77496839
48NME10.76671574
49PAK30.76395728
50PRKCE0.76261121
51RPS6KA50.75602597
52EPHB20.75535157
53RPS6KA60.72884963
54CSNK1G20.72716767
55ERBB20.70667724
56PKN10.69182095
57ITK0.68442924
58MAPKAPK30.68179411
59WEE10.67598924
60FGFR20.67307285
61PLK20.67024544
62MAP2K70.66732293
63PRKCQ0.66654652
64PRKACA0.66528385
65SIK20.64458598
66GRK50.63580945
67MAP3K90.59313220
68CAMK2A0.58266134
69CSNK1G30.56341233
70TYRO30.55158978
71GRK60.54118236
72CSNK1G10.54117261
73STK110.54109670
74SGK4940.53808431
75SGK2230.53808431
76SGK20.52478365
77CAMK10.51378210
78CSNK1A10.51145793
79MKNK20.51039321
80PRKCA0.49965878
81OBSCN0.48447793
82SYK0.47705255
83MAP2K60.47651991
84KDR0.45604837
85PTK2B0.43865737
86CDK80.43274212
87PASK0.42969829
88TAF10.41924630
89CAMKK10.40286407
90CHUK0.39447147
91PRKCZ0.37848711
92IGF1R0.37772949
93RPS6KA20.37058869
94PRKCH0.36079522
95DYRK30.35834250
96PLK40.34763232
97PRKG10.33333580
98MAP2K10.33245346
99PRKD20.32765650
100EPHA40.32425604

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001902.97867622
2Phototransduction_Homo sapiens_hsa047442.72248881
3Nicotine addiction_Homo sapiens_hsa050332.51468307
4Ribosome_Homo sapiens_hsa030102.47382043
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.45728544
6Parkinsons disease_Homo sapiens_hsa050122.37730366
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.31964904
8Linoleic acid metabolism_Homo sapiens_hsa005912.18547984
9Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.12838938
10Nitrogen metabolism_Homo sapiens_hsa009102.11471891
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.02643235
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.01823641
13Cardiac muscle contraction_Homo sapiens_hsa042601.98636560
14Tryptophan metabolism_Homo sapiens_hsa003801.96572144
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.94985624
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.83305073
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.80311748
18Alzheimers disease_Homo sapiens_hsa050101.71632905
19Morphine addiction_Homo sapiens_hsa050321.69860027
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.66787793
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.55802930
22Huntingtons disease_Homo sapiens_hsa050161.54477429
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.52760456
24Caffeine metabolism_Homo sapiens_hsa002321.51539096
25Protein export_Homo sapiens_hsa030601.47963901
26Taste transduction_Homo sapiens_hsa047421.47312426
27RNA polymerase_Homo sapiens_hsa030201.41404744
28Butanoate metabolism_Homo sapiens_hsa006501.40582448
29Homologous recombination_Homo sapiens_hsa034401.39897989
30Olfactory transduction_Homo sapiens_hsa047401.39276583
31Chemical carcinogenesis_Homo sapiens_hsa052041.28903072
32Serotonergic synapse_Homo sapiens_hsa047261.28632028
33Asthma_Homo sapiens_hsa053101.28103742
34GABAergic synapse_Homo sapiens_hsa047271.26732698
35Selenocompound metabolism_Homo sapiens_hsa004501.23796496
36Retinol metabolism_Homo sapiens_hsa008301.23793934
37Sulfur metabolism_Homo sapiens_hsa009201.23373279
38Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.23357178
39Ether lipid metabolism_Homo sapiens_hsa005651.22980634
40Circadian entrainment_Homo sapiens_hsa047131.22342467
41Glutamatergic synapse_Homo sapiens_hsa047241.19358780
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.17454806
43Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.14242104
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.10929452
45Basal transcription factors_Homo sapiens_hsa030221.04898832
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.01797627
47RNA degradation_Homo sapiens_hsa030181.01067457
48Insulin secretion_Homo sapiens_hsa049111.00419482
49Primary immunodeficiency_Homo sapiens_hsa053400.97975365
50Glycerolipid metabolism_Homo sapiens_hsa005610.97596802
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.96417157
52Fanconi anemia pathway_Homo sapiens_hsa034600.94738617
53Arachidonic acid metabolism_Homo sapiens_hsa005900.91791211
54Peroxisome_Homo sapiens_hsa041460.91214918
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.89112328
56Vitamin digestion and absorption_Homo sapiens_hsa049770.87495045
57Primary bile acid biosynthesis_Homo sapiens_hsa001200.84956638
58Graft-versus-host disease_Homo sapiens_hsa053320.80898486
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.80441282
60ABC transporters_Homo sapiens_hsa020100.78498802
61Basal cell carcinoma_Homo sapiens_hsa052170.76403987
62Calcium signaling pathway_Homo sapiens_hsa040200.75424437
63Fat digestion and absorption_Homo sapiens_hsa049750.75396513
64Cholinergic synapse_Homo sapiens_hsa047250.73208980
65Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70932553
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70376445
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69498460
68Histidine metabolism_Homo sapiens_hsa003400.68835561
69Autoimmune thyroid disease_Homo sapiens_hsa053200.66579567
70Sulfur relay system_Homo sapiens_hsa041220.65740725
71Cocaine addiction_Homo sapiens_hsa050300.65735900
72Collecting duct acid secretion_Homo sapiens_hsa049660.65640030
73Ovarian steroidogenesis_Homo sapiens_hsa049130.65283062
74Salivary secretion_Homo sapiens_hsa049700.64009179
75Allograft rejection_Homo sapiens_hsa053300.63504872
76One carbon pool by folate_Homo sapiens_hsa006700.63015034
77Type I diabetes mellitus_Homo sapiens_hsa049400.62653564
78Dopaminergic synapse_Homo sapiens_hsa047280.60917634
79Hedgehog signaling pathway_Homo sapiens_hsa043400.57090755
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56743452
81Rheumatoid arthritis_Homo sapiens_hsa053230.54313405
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52993721
83Amphetamine addiction_Homo sapiens_hsa050310.52384009
84Purine metabolism_Homo sapiens_hsa002300.52307186
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.51633714
86Gastric acid secretion_Homo sapiens_hsa049710.49808689
87beta-Alanine metabolism_Homo sapiens_hsa004100.49101603
88cAMP signaling pathway_Homo sapiens_hsa040240.48863496
89Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.48519115
90Type II diabetes mellitus_Homo sapiens_hsa049300.45601484
91Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.44697826
92Renin secretion_Homo sapiens_hsa049240.44293472
93Metabolic pathways_Homo sapiens_hsa011000.44237297
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42352613
95Proteasome_Homo sapiens_hsa030500.40802722
96Oxytocin signaling pathway_Homo sapiens_hsa049210.40084651
97Regulation of autophagy_Homo sapiens_hsa041400.39481341
98Pyrimidine metabolism_Homo sapiens_hsa002400.36293758
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35514400
100Dorso-ventral axis formation_Homo sapiens_hsa043200.35197202

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