BTBD8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)7.60445937
2central nervous system myelination (GO:0022010)7.60445937
3fatty acid elongation (GO:0030497)5.98265037
4synaptic vesicle maturation (GO:0016188)5.81378524
5synaptic vesicle exocytosis (GO:0016079)5.59253129
6ionotropic glutamate receptor signaling pathway (GO:0035235)5.47356129
7glutamate secretion (GO:0014047)5.39126005
8membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.30645959
9regulation of short-term neuronal synaptic plasticity (GO:0048172)5.22403175
10cellular potassium ion homeostasis (GO:0030007)4.99224643
11cerebellar granule cell differentiation (GO:0021707)4.94897917
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.94647958
13neuronal action potential propagation (GO:0019227)4.93413534
14synaptic vesicle docking involved in exocytosis (GO:0016081)4.90459220
15gamma-aminobutyric acid signaling pathway (GO:0007214)4.87971032
16synaptic transmission, glutamatergic (GO:0035249)4.86518345
17neuron-neuron synaptic transmission (GO:0007270)4.78585925
18glutamate receptor signaling pathway (GO:0007215)4.75099562
19piRNA metabolic process (GO:0034587)4.58957848
20neuron cell-cell adhesion (GO:0007158)4.55355777
21deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.53900322
22regulation of synaptic vesicle exocytosis (GO:2000300)4.53668016
23cerebellar Purkinje cell differentiation (GO:0021702)4.48543586
24short-term memory (GO:0007614)4.46264112
25long-chain fatty acid biosynthetic process (GO:0042759)4.40633917
26positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.38378937
27neurotransmitter secretion (GO:0007269)4.35804157
28glutathione biosynthetic process (GO:0006750)4.34893661
29regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.33078770
30mast cell degranulation (GO:0043303)4.32792085
31mast cell activation involved in immune response (GO:0002279)4.32792085
32vocalization behavior (GO:0071625)4.32325070
33protein localization to synapse (GO:0035418)4.29164854
34sodium ion export (GO:0071436)4.27856443
35mannosylation (GO:0097502)4.20253309
36regulation of cell proliferation involved in kidney development (GO:1901722)4.19078196
37exploration behavior (GO:0035640)4.15803286
38presynaptic membrane assembly (GO:0097105)4.12918008
39regulation of synaptic vesicle transport (GO:1902803)4.07799123
40gamma-aminobutyric acid transport (GO:0015812)4.06177927
41presynaptic membrane organization (GO:0097090)4.04601551
42positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.03253575
43regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.98581638
44lymphoid progenitor cell differentiation (GO:0002320)3.96961739
45nonribosomal peptide biosynthetic process (GO:0019184)3.96046947
46positive regulation of dendritic spine morphogenesis (GO:0061003)3.89829822
47C4-dicarboxylate transport (GO:0015740)3.88679466
48DNA methylation involved in gamete generation (GO:0043046)3.87255877
49regulation of excitatory postsynaptic membrane potential (GO:0060079)3.83557849
50CENP-A containing nucleosome assembly (GO:0034080)3.77786654
51postsynaptic membrane organization (GO:0001941)3.77324486
52membrane depolarization during action potential (GO:0086010)3.75293942
53regulation of response to osmotic stress (GO:0047484)3.73200489
54negative regulation of protein localization to cell surface (GO:2000009)3.72102281
55regulation of postsynaptic membrane potential (GO:0060078)3.71973178
56negative regulation of synaptic transmission, GABAergic (GO:0032229)3.67960834
57chromatin remodeling at centromere (GO:0031055)3.66116867
58myelin maintenance (GO:0043217)3.63973526
59cellular sodium ion homeostasis (GO:0006883)3.63199622
60neurotransmitter-gated ion channel clustering (GO:0072578)3.63134636
61G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.61301926
62cell differentiation in hindbrain (GO:0021533)3.60394001
63detection of calcium ion (GO:0005513)3.58780255
64response to redox state (GO:0051775)3.56939189
65positive regulation of synapse maturation (GO:0090129)3.54937803
66regulation of neurotransmitter secretion (GO:0046928)3.50705395
67neurotransmitter transport (GO:0006836)3.50281701
68regulation of dendritic spine morphogenesis (GO:0061001)3.49877729
69cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.48307572
70positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.47930662
71long-term memory (GO:0007616)3.47580236
72locomotory exploration behavior (GO:0035641)3.45259357
73regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.44202264
74membrane depolarization (GO:0051899)3.43622109
75regulation of exit from mitosis (GO:0007096)3.43315657
76regulation of neuronal synaptic plasticity (GO:0048168)3.42416243
77regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.42382064
78transmission of nerve impulse (GO:0019226)3.42023882
79positive regulation of oligodendrocyte differentiation (GO:0048714)3.41436694
80response to histamine (GO:0034776)3.40131518
81long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.38943221
82prepulse inhibition (GO:0060134)3.38829586
83chemosensory behavior (GO:0007635)3.38439121
84axonal fasciculation (GO:0007413)3.37850049
85attachment of spindle microtubules to kinetochore (GO:0008608)3.36594842
86mast cell activation (GO:0045576)3.36479144
87potassium ion homeostasis (GO:0055075)3.35145588
88regulation of neurotransmitter levels (GO:0001505)3.34500557
89cerebellar Purkinje cell layer development (GO:0021680)3.34215813
90myelination (GO:0042552)3.33176577
91neurofilament cytoskeleton organization (GO:0060052)3.31837447
92oligodendrocyte differentiation (GO:0048709)3.31681859
93neuronal ion channel clustering (GO:0045161)3.31476238
94positive regulation of dendritic spine development (GO:0060999)3.31339198
95adult walking behavior (GO:0007628)3.30800930
96regulation of synaptic transmission, glutamatergic (GO:0051966)3.29923859
97regulation of glutamate receptor signaling pathway (GO:1900449)3.29922928
98negative regulation of dendrite morphogenesis (GO:0050774)3.29639031
99histone exchange (GO:0043486)3.27186280
100neuron recognition (GO:0008038)3.25897669
101peptide biosynthetic process (GO:0043043)3.25720550
102mitotic nuclear envelope reassembly (GO:0007084)3.25426951
103nuclear envelope reassembly (GO:0031468)3.25426951
104startle response (GO:0001964)3.21990546
105regulation of dendritic spine development (GO:0060998)3.21354970
106axon ensheathment (GO:0008366)3.20640979
107ensheathment of neurons (GO:0007272)3.20640979
108regulation of synapse structural plasticity (GO:0051823)3.20475435
109regulation of neurotransmitter transport (GO:0051588)3.20252999
110layer formation in cerebral cortex (GO:0021819)3.19947885
111regulated secretory pathway (GO:0045055)3.19635991
112regulation of transforming growth factor beta1 production (GO:0032908)3.17370452
113synaptic vesicle endocytosis (GO:0048488)3.17079932
114negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.16408329
115protein K11-linked deubiquitination (GO:0035871)3.14438200
116acidic amino acid transport (GO:0015800)3.13757963
117synaptic transmission (GO:0007268)3.13270267
118negative regulation of dendrite development (GO:2000171)3.12656231
119regulation of vesicle fusion (GO:0031338)3.12046498
120N-terminal protein amino acid acetylation (GO:0006474)3.09750493
121positive regulation of synaptic transmission, GABAergic (GO:0032230)3.09055838
122serotonin metabolic process (GO:0042428)3.08534355
123regulation of voltage-gated calcium channel activity (GO:1901385)3.08020725
124regulation of synaptic plasticity (GO:0048167)3.07499850
125positive regulation of potassium ion transmembrane transport (GO:1901381)3.06146810
126DNA ligation (GO:0006266)3.05996403
127response to lipoprotein particle (GO:0055094)3.05959000
128peptidyl-cysteine modification (GO:0018198)3.05688074
129regulation of long-term neuronal synaptic plasticity (GO:0048169)3.04007865
130retinal cone cell development (GO:0046549)3.03902240
131positive regulation of membrane potential (GO:0045838)3.02558601
132dendritic spine morphogenesis (GO:0060997)3.01935266
133megakaryocyte development (GO:0035855)3.00334704
134neuroblast proliferation (GO:0007405)3.00015492
135synapse assembly (GO:0007416)2.99603936
136long-term synaptic potentiation (GO:0060291)2.98404863
137long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.97877931
138cell communication by electrical coupling (GO:0010644)2.97350053
139photoreceptor cell differentiation (GO:0046530)2.91788729
140eye photoreceptor cell differentiation (GO:0001754)2.91788729
141adult behavior (GO:0030534)2.90882382
142regulation of synapse maturation (GO:0090128)2.90143526
143mismatch repair (GO:0006298)2.88234175
144righting reflex (GO:0060013)2.88039312
145neuromuscular synaptic transmission (GO:0007274)2.86125635
146membrane hyperpolarization (GO:0060081)2.84638194
147mitotic sister chromatid segregation (GO:0000070)2.84568035
148DNA replication-independent nucleosome organization (GO:0034724)2.83035070
149DNA replication-independent nucleosome assembly (GO:0006336)2.83035070
150cholesterol biosynthetic process (GO:0006695)2.82951514
151membrane tubulation (GO:0097320)2.81677877
152translesion synthesis (GO:0019985)2.81037181
153protein localization to chromosome, centromeric region (GO:0071459)2.79772928
154lysosome localization (GO:0032418)2.76750675
155leukocyte degranulation (GO:0043299)2.76201631
156protein localization to kinetochore (GO:0034501)2.75153759
157cellular extravasation (GO:0045123)2.75090840
158telomere maintenance via recombination (GO:0000722)2.74834106
159GMP metabolic process (GO:0046037)2.74736912
160establishment of mitochondrion localization (GO:0051654)2.74362039
161rRNA methylation (GO:0031167)2.74155958
162negative regulation of interleukin-8 production (GO:0032717)2.73431292
163positive regulation of glomerulus development (GO:0090193)2.73415368
164neuron fate determination (GO:0048664)2.73024226
165establishment of mitotic spindle localization (GO:0040001)2.72730178
166glycerophospholipid catabolic process (GO:0046475)2.70882538
167mitotic recombination (GO:0006312)2.70431949
168regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.70308315
169very long-chain fatty acid metabolic process (GO:0000038)2.69970124
170fatty-acyl-CoA metabolic process (GO:0035337)2.68918422
171nucleotide transmembrane transport (GO:1901679)2.68523043
172positive regulation of transforming growth factor beta production (GO:0071636)2.68227888
173male meiosis (GO:0007140)2.66028542
174negative regulation of acute inflammatory response (GO:0002674)2.65201658
175nucleotide-excision repair, DNA gap filling (GO:0006297)2.64860028
176sterol biosynthetic process (GO:0016126)2.62836597
177meiotic chromosome segregation (GO:0045132)2.61880367
178regulation of protein glycosylation (GO:0060049)2.60568824
179proteasome assembly (GO:0043248)2.59270921
180positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.58642910
181platelet dense granule organization (GO:0060155)2.58466427
182establishment of mitotic spindle orientation (GO:0000132)2.58139573
183DNA strand elongation involved in DNA replication (GO:0006271)2.57244158
184sister chromatid segregation (GO:0000819)2.56979903
185spindle checkpoint (GO:0031577)2.56527900
186L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.56368509
187base-excision repair, AP site formation (GO:0006285)2.55533370
188intracellular pH reduction (GO:0051452)2.55095725
189peripheral nervous system neuron development (GO:0048935)2.54001222
190microtubule polymerization or depolymerization (GO:0031109)2.53913983
191positive regulation of cell fate commitment (GO:0010455)2.53804137
192protein K63-linked deubiquitination (GO:0070536)2.52574971
193mitotic chromosome condensation (GO:0007076)2.51381364
194pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.50603262
195negative regulation of neurotransmitter transport (GO:0051589)2.50579929
196phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.50557598
197DNA strand elongation (GO:0022616)2.50537464
198magnesium ion transport (GO:0015693)2.49877080
199meiotic cell cycle (GO:0051321)2.49538504
200female gamete generation (GO:0007292)2.49101371

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.84750361
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.79031914
3ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.75438254
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.51612343
5MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.40511894
6AR_21909140_ChIP-Seq_LNCAP_Human3.33439744
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.09490315
8REST_21632747_ChIP-Seq_MESCs_Mouse2.76962984
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.71138057
10TAF15_26573619_Chip-Seq_HEK293_Human2.61719923
11EWS_26573619_Chip-Seq_HEK293_Human2.46817145
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.44725866
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.42540863
14JARID2_20064375_ChIP-Seq_MESCs_Mouse2.42010097
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.31380594
16CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.30392507
17STAT6_21828071_ChIP-Seq_BEAS2B_Human2.25701048
18REST_18959480_ChIP-ChIP_MESCs_Mouse2.20177791
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.14317061
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.10705462
21EZH2_22144423_ChIP-Seq_EOC_Human2.08756493
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.05437788
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.03894919
24SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.03668994
25DROSHA_22980978_ChIP-Seq_HELA_Human2.02598141
26EZH2_27304074_Chip-Seq_ESCs_Mouse2.02500508
27MTF2_20144788_ChIP-Seq_MESCs_Mouse2.01520210
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.01028435
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.95621728
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.95173171
31JARID2_20075857_ChIP-Seq_MESCs_Mouse1.93491210
32GBX2_23144817_ChIP-Seq_PC3_Human1.93325542
33SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.93296653
34SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.92853032
35EZH2_18974828_ChIP-Seq_MESCs_Mouse1.90562154
36RNF2_18974828_ChIP-Seq_MESCs_Mouse1.90562154
37KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.90275506
38OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.89629246
39AR_21572438_ChIP-Seq_LNCaP_Human1.89613557
40EED_16625203_ChIP-ChIP_MESCs_Mouse1.87810678
41FUS_26573619_Chip-Seq_HEK293_Human1.86803752
42TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.86302328
43IGF1R_20145208_ChIP-Seq_DFB_Human1.83835880
44RARB_27405468_Chip-Seq_BRAIN_Mouse1.82560697
45NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.80605079
46P300_19829295_ChIP-Seq_ESCs_Human1.79178781
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.74177021
48EZH2_27294783_Chip-Seq_ESCs_Mouse1.71165569
49SUZ12_27294783_Chip-Seq_ESCs_Mouse1.70648779
50RNF2_27304074_Chip-Seq_ESCs_Mouse1.69824648
51ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67931943
52E2F4_17652178_ChIP-ChIP_JURKAT_Human1.66851736
53ER_23166858_ChIP-Seq_MCF-7_Human1.59265177
54LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.53396687
55E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.53070634
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.52211396
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50653706
58VDR_22108803_ChIP-Seq_LS180_Human1.50160803
59CBX2_27304074_Chip-Seq_ESCs_Mouse1.49486849
60RNF2_27304074_Chip-Seq_NSC_Mouse1.48826954
61BMI1_23680149_ChIP-Seq_NPCS_Mouse1.48774930
62CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.48212821
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47317560
64EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.45594136
65NANOG_18555785_Chip-Seq_ESCs_Mouse1.44614106
66* PRDM14_20953172_ChIP-Seq_ESCs_Human1.43807030
67SMAD3_21741376_ChIP-Seq_EPCs_Human1.42858318
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.39273944
69MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.39033668
70TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39019186
71STAT3_23295773_ChIP-Seq_U87_Human1.37495201
72TAL1_26923725_Chip-Seq_HPCs_Mouse1.35825767
73PCGF2_27294783_Chip-Seq_ESCs_Mouse1.34107833
74NR3C1_23031785_ChIP-Seq_PC12_Mouse1.33257074
75SCL_19346495_ChIP-Seq_HPC-7_Human1.32318202
76SOX2_21211035_ChIP-Seq_LN229_Gbm1.32270403
77IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.31914472
78SUZ12_18555785_Chip-Seq_ESCs_Mouse1.30450415
79* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.30274834
80IRF1_19129219_ChIP-ChIP_H3396_Human1.28688389
81RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.27553987
82NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.26692923
83MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.26664587
84ZNF274_21170338_ChIP-Seq_K562_Hela1.25654577
85GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25189110
86IKZF1_21737484_ChIP-ChIP_HCT116_Human1.24528129
87HOXB4_20404135_ChIP-ChIP_EML_Mouse1.24293616
88FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.24123000
89CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.23681484
90P53_22127205_ChIP-Seq_FIBROBLAST_Human1.23119961
91CMYC_18555785_Chip-Seq_ESCs_Mouse1.22361824
92NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21931557
93CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21809220
94TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20359017
95AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19440511
96TCF4_23295773_ChIP-Seq_U87_Human1.17547060
97PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.16117855
98UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15560765
99P53_22387025_ChIP-Seq_ESCs_Mouse1.14288753
100BCAT_22108803_ChIP-Seq_LS180_Human1.14214826
101* AR_19668381_ChIP-Seq_PC3_Human1.13879058
102EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.12688153
103RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.12515485
104PU1_27457419_Chip-Seq_LIVER_Mouse1.09232543
105LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09139821
106LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09138317
107RUNX2_22187159_ChIP-Seq_PCA_Human1.08752479
108FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.05805422
109* SMAD4_21799915_ChIP-Seq_A2780_Human1.05595753
110RUNX_20019798_ChIP-Seq_JUKART_Human1.04703947
111ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.04675606
112SRF_21415370_ChIP-Seq_HL-1_Mouse1.04674921
113TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04128621
114RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04033192
115STAT3_18555785_Chip-Seq_ESCs_Mouse1.01970567
116FLI1_21867929_ChIP-Seq_TH2_Mouse1.01663698
117MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01468516
118CTBP1_25329375_ChIP-Seq_LNCAP_Human1.01205916
119RBPJ_22232070_ChIP-Seq_NCS_Mouse1.00603027
120FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00594631
121P300_18555785_Chip-Seq_ESCs_Mouse1.00387185
122CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.00350443
123POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00315946
124TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00315946
125FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99687009
126AR_25329375_ChIP-Seq_VCAP_Human0.99599438
127MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99392251
128CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.98667010
129E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98620132
130NFE2_27457419_Chip-Seq_LIVER_Mouse0.98403809
131WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98133613
132YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97982163
133PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.97827259
134PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.97262010
135GATA1_22025678_ChIP-Seq_K562_Human0.97178272
136HTT_18923047_ChIP-ChIP_STHdh_Human0.97106226
137KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.96848953
138HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.96704016
139KLF5_20875108_ChIP-Seq_MESCs_Mouse0.96278185
140CBP_20019798_ChIP-Seq_JUKART_Human0.96177839
141IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96177839
142SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.96101485
143SOX9_26525672_Chip-Seq_HEART_Mouse0.95786428
144E2F1_18555785_Chip-Seq_ESCs_Mouse0.94727433
145SMAD_19615063_ChIP-ChIP_OVARY_Human0.93194042
146CTBP2_25329375_ChIP-Seq_LNCAP_Human0.92420147
147SOX2_18555785_Chip-Seq_ESCs_Mouse0.91663443
148PIAS1_25552417_ChIP-Seq_VCAP_Human0.91214649
149KDM2B_26808549_Chip-Seq_REH_Human0.89950352
150SUZ12_27294783_Chip-Seq_NPCs_Mouse0.88932900
151* SOX2_19829295_ChIP-Seq_ESCs_Human0.88629422
152* NANOG_19829295_ChIP-Seq_ESCs_Human0.88629422
153RUNX1_27457419_Chip-Seq_LIVER_Mouse0.87503358
154OCT4_18555785_Chip-Seq_ESCs_Mouse0.87103649
155SALL1_21062744_ChIP-ChIP_HESCs_Human0.86389358
156TOP2B_26459242_ChIP-Seq_MCF-7_Human0.85421645
157CTNNB1_20460455_ChIP-Seq_HCT116_Human0.84424583
158EZH2_27294783_Chip-Seq_NPCs_Mouse0.83461418

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009046_muscle_twitch3.96747844
2MP0005451_abnormal_body_composition3.51396309
3MP0001986_abnormal_taste_sensitivity3.42863187
4MP0004147_increased_porphyrin_level3.35119633
5MP0001188_hyperpigmentation3.34742114
6MP0008877_abnormal_DNA_methylation3.27225018
7MP0002396_abnormal_hematopoietic_system3.03937960
8MP0002063_abnormal_learning/memory/cond2.86764639
9MP0002572_abnormal_emotion/affect_behav2.56122397
10MP0010094_abnormal_chromosome_stability2.53573471
11MP0000920_abnormal_myelination2.52619511
12MP0004742_abnormal_vestibular_system2.39610365
13MP0000569_abnormal_digit_pigmentation2.39049059
14MP0003183_abnormal_peptide_metabolism2.32630450
15MP0005409_darkened_coat_color2.30923539
16MP0001440_abnormal_grooming_behavior2.19920603
17MP0001501_abnormal_sleep_pattern2.18113446
18MP0002067_abnormal_sensory_capabilities2.17335658
19MP0001529_abnormal_vocalization2.13959390
20MP0003136_yellow_coat_color2.13163706
21MP0002736_abnormal_nociception_after2.10491127
22MP0009780_abnormal_chondrocyte_physiolo2.09523352
23MP0005379_endocrine/exocrine_gland_phen2.07578146
24MP0004270_analgesia2.04185186
25MP0005410_abnormal_fertilization2.01928390
26MP0001348_abnormal_lacrimal_gland1.95997820
27MP0004859_abnormal_synaptic_plasticity1.93321406
28MP0006054_spinal_hemorrhage1.91181536
29MP0003941_abnormal_skin_development1.87345942
30MP0003806_abnormal_nucleotide_metabolis1.83713867
31MP0003122_maternal_imprinting1.83177530
32MP0008057_abnormal_DNA_replication1.81923718
33MP0003950_abnormal_plasma_membrane1.81487878
34MP0003879_abnormal_hair_cell1.78220040
35MP0008260_abnormal_autophagy1.77454963
36MP0010678_abnormal_skin_adnexa1.73938937
37MP0006292_abnormal_olfactory_placode1.71084545
38MP0002557_abnormal_social/conspecific_i1.69927215
39MP0009379_abnormal_foot_pigmentation1.67781671
40MP0003329_amyloid_beta_deposits1.67693452
41MP0000383_abnormal_hair_follicle1.67606505
42MP0005075_abnormal_melanosome_morpholog1.67261900
43MP0002184_abnormal_innervation1.65529733
44MP0002272_abnormal_nervous_system1.65260729
45MP0001905_abnormal_dopamine_level1.65212730
46MP0003880_abnormal_central_pattern1.64383200
47MP0000778_abnormal_nervous_system1.62327547
48MP0004924_abnormal_behavior1.60747378
49MP0005386_behavior/neurological_phenoty1.60747378
50MP0004811_abnormal_neuron_physiology1.59883368
51MP0000685_abnormal_immune_system1.54983519
52MP0003718_maternal_effect1.48136366
53MP0010234_abnormal_vibrissa_follicle1.47549114
54MP0002882_abnormal_neuron_morphology1.44376573
55MP0008007_abnormal_cellular_replicative1.43750391
56MP0003632_abnormal_nervous_system1.41695780
57MP0003633_abnormal_nervous_system1.41325828
58MP0005551_abnormal_eye_electrophysiolog1.39877297
59MP0002066_abnormal_motor_capabilities/c1.39785492
60MP0002734_abnormal_mechanical_nocicepti1.38574058
61MP0000955_abnormal_spinal_cord1.38362153
62MP0000604_amyloidosis1.35439390
63MP0005646_abnormal_pituitary_gland1.32392150
64MP0002876_abnormal_thyroid_physiology1.31522780
65MP0008932_abnormal_embryonic_tissue1.28947317
66MP0001929_abnormal_gametogenesis1.27718493
67MP0005645_abnormal_hypothalamus_physiol1.26198022
68MP0003690_abnormal_glial_cell1.26152453
69MP0005174_abnormal_tail_pigmentation1.25747961
70MP0004782_abnormal_surfactant_physiolog1.20009694
71MP0004036_abnormal_muscle_relaxation1.18924607
72MP0008569_lethality_at_weaning1.18911882
73MP0006276_abnormal_autonomic_nervous1.18405484
74MP0002064_seizures1.17954431
75MP0009745_abnormal_behavioral_response1.15438024
76MP0002796_impaired_skin_barrier1.13082424
77MP0000427_abnormal_hair_cycle1.12840485
78MP0004885_abnormal_endolymph1.12134482
79MP0001835_abnormal_antigen_presentation1.11997928
80MP0003077_abnormal_cell_cycle1.11863253
81MP0002822_catalepsy1.09578842
82MP0002638_abnormal_pupillary_reflex1.09459987
83MP0000462_abnormal_digestive_system1.09138122
84MP0006035_abnormal_mitochondrial_morpho1.08790193
85MP0000465_gastrointestinal_hemorrhage1.06557401
86MP0002735_abnormal_chemical_nociception1.03563201
87MP0008872_abnormal_physiological_respon1.03158284
88MP0002102_abnormal_ear_morphology1.02810706
89MP0002152_abnormal_brain_morphology1.01093126
90MP0003787_abnormal_imprinting1.00860047
91MP0003121_genomic_imprinting0.99652447
92MP0002163_abnormal_gland_morphology0.99455265
93MP0003111_abnormal_nucleus_morphology0.99360893
94MP0000566_synostosis0.98770730
95MP0003123_paternal_imprinting0.97842868
96MP0003698_abnormal_male_reproductive0.97208245
97MP0005171_absent_coat_pigmentation0.96616155
98MP0002909_abnormal_adrenal_gland0.95516031
99MP0001177_atelectasis0.95373046
100MP0001299_abnormal_eye_distance/0.95150065
101MP0004381_abnormal_hair_follicle0.94209474
102MP0008874_decreased_physiological_sensi0.92833983
103MP0002877_abnormal_melanocyte_morpholog0.92665982
104MP0002229_neurodegeneration0.91621307
105MP0004043_abnormal_pH_regulation0.89068731
106MP0005187_abnormal_penis_morphology0.88520201
107MP0003634_abnormal_glial_cell0.88268575
108MP0003011_delayed_dark_adaptation0.88205062
109MP0009697_abnormal_copulation0.87743182
110MP0005423_abnormal_somatic_nervous0.87703714
111MP0001485_abnormal_pinna_reflex0.87691154
112MP0003137_abnormal_impulse_conducting0.87334595
113MP0004510_myositis0.87285779
114MP0008058_abnormal_DNA_repair0.87154457
115MP0001963_abnormal_hearing_physiology0.85815461
116MP0005671_abnormal_response_to0.84684271
117MP0002752_abnormal_somatic_nervous0.82791475
118MP0002398_abnormal_bone_marrow0.81994910
119MP0004142_abnormal_muscle_tone0.79215012
120MP0010386_abnormal_urinary_bladder0.79016228
121MP0001486_abnormal_startle_reflex0.78613594
122MP0000653_abnormal_sex_gland0.76924204
123MP0008875_abnormal_xenobiotic_pharmacok0.76866960
124MP0003631_nervous_system_phenotype0.76126390
125MP0004957_abnormal_blastocyst_morpholog0.76033370
126MP0001502_abnormal_circadian_rhythm0.75986551
127MP0001984_abnormal_olfaction0.75932661
128MP0006072_abnormal_retinal_apoptosis0.75634842
129MP0005253_abnormal_eye_physiology0.75442008
130MP0002090_abnormal_vision0.74559550
131MP0002210_abnormal_sex_determination0.72389412
132MP0000372_irregular_coat_pigmentation0.72227440
133MP0002069_abnormal_eating/drinking_beha0.72083161
134MP0003195_calcinosis0.71914913
135MP0004085_abnormal_heartbeat0.71748961
136MP0000647_abnormal_sebaceous_gland0.71627943
137MP0003635_abnormal_synaptic_transmissio0.70503626
138MP0001968_abnormal_touch/_nociception0.69121047
139MP0001970_abnormal_pain_threshold0.68514363
140MP0002733_abnormal_thermal_nociception0.67588059
141MP0002751_abnormal_autonomic_nervous0.66470815
142MP0004215_abnormal_myocardial_fiber0.65714491
143MP0005535_abnormal_body_temperature0.65362319
144MP0000631_abnormal_neuroendocrine_gland0.65278111
145MP0002161_abnormal_fertility/fecundity0.64750879
146MP0000013_abnormal_adipose_tissue0.62055613
147MP0005394_taste/olfaction_phenotype0.61322562
148MP0005499_abnormal_olfactory_system0.61322562
149MP0004484_altered_response_of0.61130794
150MP0002234_abnormal_pharynx_morphology0.58720397
151MP0000639_abnormal_adrenal_gland0.58324759
152MP0002160_abnormal_reproductive_system0.56528065
153MP0000026_abnormal_inner_ear0.54746203
154MP0003283_abnormal_digestive_organ0.54337725
155MP0010770_preweaning_lethality0.51834052

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.24417531
2Febrile seizures (HP:0002373)7.87659773
3Atonic seizures (HP:0010819)7.49246225
4Focal seizures (HP:0007359)6.26152221
5Congenital nonbullous ichthyosiform erythroderma (HP:0007479)6.13131040
6Action tremor (HP:0002345)5.98944396
7Epileptic encephalopathy (HP:0200134)5.88456120
8Absence seizures (HP:0002121)5.21115261
9Dialeptic seizures (HP:0011146)4.98147123
10Progressive cerebellar ataxia (HP:0002073)4.57760676
11Congenital ichthyosiform erythroderma (HP:0007431)4.32476764
12Type II lissencephaly (HP:0007260)4.26748250
13Gaze-evoked nystagmus (HP:0000640)4.11906886
14Parakeratosis (HP:0001036)4.11713352
15Generalized tonic-clonic seizures (HP:0002069)4.02187853
16Broad-based gait (HP:0002136)4.01000871
17Dysdiadochokinesis (HP:0002075)3.99810103
18Cerebellar dysplasia (HP:0007033)3.91499753
19Impaired vibration sensation in the lower limbs (HP:0002166)3.89565699
20Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.88930974
21Degeneration of the lateral corticospinal tracts (HP:0002314)3.74263619
22Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.74263619
23Truncal ataxia (HP:0002078)3.68903644
24Intention tremor (HP:0002080)3.67952949
25Progressive inability to walk (HP:0002505)3.38520878
26Dysmetric saccades (HP:0000641)3.37919366
27Sensory axonal neuropathy (HP:0003390)3.36201771
28Epileptiform EEG discharges (HP:0011182)3.32189342
29Dysmetria (HP:0001310)3.30915682
30Limb dystonia (HP:0002451)3.28364223
31EEG with generalized epileptiform discharges (HP:0011198)3.10220040
32Impaired smooth pursuit (HP:0007772)3.07191892
33Status epilepticus (HP:0002133)3.01806322
34Supranuclear gaze palsy (HP:0000605)3.01596367
35Patchy hypopigmentation of hair (HP:0011365)2.93612229
36Neurofibrillary tangles (HP:0002185)2.93246361
37Diplopia (HP:0000651)2.92373585
38Abnormality of binocular vision (HP:0011514)2.92373585
39White forelock (HP:0002211)2.90456250
40Ankle clonus (HP:0011448)2.90110384
41Abnormal eating behavior (HP:0100738)2.88156890
42Increased neuronal autofluorescent lipopigment (HP:0002074)2.84359244
43Amblyopia (HP:0000646)2.83736978
44Hypothermia (HP:0002045)2.83358948
45Erythroderma (HP:0001019)2.82985202
46Anterior segment dysgenesis (HP:0007700)2.82635191
47Retinal dysplasia (HP:0007973)2.80999338
48Hypsarrhythmia (HP:0002521)2.79617532
49Abnormal hair whorl (HP:0010721)2.79058381
50Clumsiness (HP:0002312)2.78862861
51Hemiparesis (HP:0001269)2.76985811
52Urinary urgency (HP:0000012)2.75700641
53Insidious onset (HP:0003587)2.72818605
54Termporal pattern (HP:0011008)2.72818605
55Polyphagia (HP:0002591)2.70883277
56Urinary bladder sphincter dysfunction (HP:0002839)2.67220563
57Abnormality of ocular smooth pursuit (HP:0000617)2.63168671
58Chin dimple (HP:0010751)2.63121283
59Postural instability (HP:0002172)2.57363160
60Mutism (HP:0002300)2.55498609
61Horizontal nystagmus (HP:0000666)2.53087723
62Impaired vibratory sensation (HP:0002495)2.52855375
63Absent speech (HP:0001344)2.48175445
64Severe visual impairment (HP:0001141)2.45712464
65Drooling (HP:0002307)2.45358006
66Poor eye contact (HP:0000817)2.41272733
67Postural tremor (HP:0002174)2.39068929
68Abnormality of the parathyroid morphology (HP:0011766)2.37777835
69Abnormality of the corticospinal tract (HP:0002492)2.37324064
70Ectropion (HP:0000656)2.36435104
71Lower limb muscle weakness (HP:0007340)2.33372988
72Abnormal auditory evoked potentials (HP:0006958)2.32861666
73Spastic tetraplegia (HP:0002510)2.31559852
74Depression (HP:0000716)2.30894846
75Hemiplegia (HP:0002301)2.28637322
76Gait imbalance (HP:0002141)2.27842046
77Focal dystonia (HP:0004373)2.25441984
78Excessive salivation (HP:0003781)2.24963000
79Cerebral hypomyelination (HP:0006808)2.22863598
80Morphological abnormality of the pyramidal tract (HP:0002062)2.22545102
81Amyotrophic lateral sclerosis (HP:0007354)2.21706382
82Chronic otitis media (HP:0000389)2.21129893
83Clitoromegaly (HP:0000057)2.19839231
84Hypoplasia of the brainstem (HP:0002365)2.17333217
85Aplasia/Hypoplasia of the brainstem (HP:0007362)2.17333217
86Spastic gait (HP:0002064)2.16478586
87Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.14800891
88Abnormality of the prostate (HP:0008775)2.14296350
89Visual hallucinations (HP:0002367)2.12666951
90Increased cerebral lipofuscin (HP:0011813)2.12369884
91Abnormality of saccadic eye movements (HP:0000570)2.12255089
92Buphthalmos (HP:0000557)2.12207214
93Anxiety (HP:0000739)2.12190225
94Esotropia (HP:0000565)2.09412467
95Delusions (HP:0000746)2.09349837
96Torticollis (HP:0000473)2.09292265
97Gait ataxia (HP:0002066)2.09045676
98Rhinitis (HP:0012384)2.08688864
99Weak cry (HP:0001612)2.07565963
100Short tibia (HP:0005736)2.07221353
101Abnormality of the clitoris (HP:0000056)2.06966340
102Abnormal social behavior (HP:0012433)2.06844942
103Impaired social interactions (HP:0000735)2.06844942
104CNS hypomyelination (HP:0003429)2.06247183
105Akinesia (HP:0002304)2.04900938
106Myokymia (HP:0002411)2.04032230
107Cerebral inclusion bodies (HP:0100314)2.03570877
108Aplasia/Hypoplasia of the sacrum (HP:0008517)2.03068555
109Gastrointestinal stroma tumor (HP:0100723)2.02402721
110Agnosia (HP:0010524)2.00015634
111Overriding aorta (HP:0002623)1.98285485
112Nephronophthisis (HP:0000090)1.97512788
113Autoamputation (HP:0001218)1.97036441
114Papilledema (HP:0001085)1.95256161
115Limb ataxia (HP:0002070)1.92365569
116Inability to walk (HP:0002540)1.91224905
117Increased circulating renin level (HP:0000848)1.89053008
118Hyperventilation (HP:0002883)1.89017928
119Bradykinesia (HP:0002067)1.88320586
120Increased IgE level (HP:0003212)1.87831314
121Muscle fiber atrophy (HP:0100295)1.87282393
122Flat occiput (HP:0005469)1.87215607
123Chronic bronchitis (HP:0004469)1.86753374
124Thyroid-stimulating hormone excess (HP:0002925)1.86392248
125Gangrene (HP:0100758)1.85047811
126Abnormality of chromosome stability (HP:0003220)1.84778018
127Hypoplastic female external genitalia (HP:0012815)1.83330804
128Incomplete penetrance (HP:0003829)1.83071955
129Methylmalonic acidemia (HP:0002912)1.82536247
130Breast hypoplasia (HP:0003187)1.81601255
131Sleep apnea (HP:0010535)1.80578569
132Peripheral hypomyelination (HP:0007182)1.80266012
133B lymphocytopenia (HP:0010976)1.79882183
134Abnormality of B cell number (HP:0010975)1.79882183
135Prostate neoplasm (HP:0100787)1.79147561
136Premature skin wrinkling (HP:0100678)1.79007723
137Cupped ear (HP:0000378)1.78958717
138Medial flaring of the eyebrow (HP:0010747)1.78357987
139Congenital primary aphakia (HP:0007707)1.77344957
140Abnormality of midbrain morphology (HP:0002418)1.77238802
141Molar tooth sign on MRI (HP:0002419)1.77238802
142Esophageal atresia (HP:0002032)1.76726233
143Aplasia/Hypoplasia of the tibia (HP:0005772)1.76419098
144Abnormality of the ischium (HP:0003174)1.74368808
145Acute myeloid leukemia (HP:0004808)1.74283440
146Abnormality of renal resorption (HP:0011038)1.72751525
147Cholecystitis (HP:0001082)1.72551603
148Abnormal gallbladder physiology (HP:0012438)1.72551603
149Muscular hypotonia of the trunk (HP:0008936)1.70765667
150Meningocele (HP:0002435)1.69110322
151Scanning speech (HP:0002168)1.68566909
152Paraplegia (HP:0010550)1.67247967
153Bone marrow hypocellularity (HP:0005528)1.67165387
154Nephrogenic diabetes insipidus (HP:0009806)1.66779995
155Abnormality of homocysteine metabolism (HP:0010919)1.66640383
156Homocystinuria (HP:0002156)1.66640383
157Barrel-shaped chest (HP:0001552)1.66376666
158Hypoglycemic seizures (HP:0002173)1.66324639
159Poor suck (HP:0002033)1.65941772
160Abnormality of incisor morphology (HP:0011063)1.65502663
161Specific learning disability (HP:0001328)1.65436534
162Abnormal respiratory motile cilium physiology (HP:0012261)1.65107690
163Genital tract atresia (HP:0001827)1.64437821
164Abnormal respiratory epithelium morphology (HP:0012253)1.64354395
165Abnormal respiratory motile cilium morphology (HP:0005938)1.64354395
166IgM deficiency (HP:0002850)1.64147165
167Abnormality of the salivary glands (HP:0010286)1.64133933
168Generalized myoclonic seizures (HP:0002123)1.63686414
169Prolonged QT interval (HP:0001657)1.63681189
170Neuronal loss in central nervous system (HP:0002529)1.63255526
171Slow saccadic eye movements (HP:0000514)1.62454105
172Lissencephaly (HP:0001339)1.62411684
173Hypoplasia of the corpus callosum (HP:0002079)1.61922234
174Fair hair (HP:0002286)1.61777810
175Abnormality of the lower motor neuron (HP:0002366)1.61598682
176Abnormal pupillary function (HP:0007686)1.61406936
177Chronic hepatic failure (HP:0100626)1.61224936
178Progressive neurologic deterioration (HP:0002344)1.60675803
179Hepatosplenomegaly (HP:0001433)1.60072197
180Clonus (HP:0002169)1.59827295
181Cerebellar hypoplasia (HP:0001321)1.59240959

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PIK3CG4.66407025
2MARK14.28981760
3EPHA44.09036515
4NTRK34.06431809
5LIMK13.48398260
6BUB13.29923301
7KIT2.96928519
8NME12.78408054
9MAP3K42.66903875
10PINK12.55729572
11DAPK22.52163171
12STK392.44651031
13MAP2K72.22841798
14MAP3K122.22059615
15VRK12.21608065
16PAK62.19493129
17GRK52.13853339
18CCNB12.07226915
19MINK12.06005809
20TNIK2.05902729
21MKNK21.99974039
22CASK1.99914978
23MAP3K91.98347115
24FLT31.94040955
25BMPR21.84480332
26BRSK11.84323474
27LMTK21.78651732
28PRKCG1.75118734
29MAPKAPK51.74461146
30CLK11.70391691
31BCR1.66960074
32TTK1.66280143
33CSNK1G21.62979660
34CDK191.62663172
35MAP3K131.62157312
36MAP4K21.60900423
37BRSK21.60650611
38MAP3K141.59682286
39OXSR11.59348955
40FRK1.58656447
41BCKDK1.57423213
42PNCK1.46466733
43CSF1R1.46052254
44PLK21.42537445
45CDC71.42419833
46CDK51.41718360
47MATK1.38236339
48MAP2K41.36741060
49TEC1.35376920
50STK161.35214697
51PKN11.33840877
52PAK31.30149697
53CAMK2A1.29442222
54WEE11.25010202
55MUSK1.24708727
56PHKG21.24593456
57PHKG11.24593456
58BMPR1B1.22855601
59CAMKK11.22746055
60ERBB41.18853396
61SIK21.16031498
62ERBB31.14839311
63ADRBK21.14775472
64TRIM281.14052994
65WNK31.11630436
66MELK1.08926430
67DYRK1A1.08606092
68DAPK11.07129440
69TAOK11.06534957
70PBK1.06137239
71MAP3K101.05621342
72STK101.04769112
73CDK81.04408490
74CSNK1G11.04107521
75SGK2231.03016045
76SGK4941.03016045
77ROCK20.97549300
78INSRR0.95130569
79EPHB10.94813015
80MAP3K110.94449987
81NTRK20.94358889
82CAMK1D0.92713010
83PRKD20.92109774
84CDC42BPA0.90205544
85TAOK30.88678604
86UHMK10.87958315
87MAP3K80.87950009
88CAMK10.87870275
89PRKD30.87638305
90STK40.86126733
91KSR10.86075231
92MAPK150.81777793
93MAP4K10.77953182
94MAP3K70.76265870
95PRKCQ0.76247928
96MARK20.76048484
97CHEK20.75607869
98MAPK70.74616014
99FGFR20.73998021
100AKT30.73178546
101NTRK10.70825990
102STK380.70282570
103SGK10.68959495
104NEK20.68312114
105SYK0.68173534
106CAMK2G0.68016066
107STK110.67216225
108DYRK20.65849539
109PLK10.64531428
110BRAF0.62849504
111CDK30.62277164
112CDK11A0.62244140
113PDK30.61803762
114PDK40.61803762
115CAMK40.61481656
116CSNK1G30.60041527
117MAPK130.59094776
118MOS0.57823389
119CAMK2D0.57516704
120PRKCH0.57094029
121ARAF0.55661323
122TESK20.55096587
123HIPK20.55092221
124CSNK1A1L0.54172766
125CHEK10.53912788
126PRKCZ0.53428516
127PRKG10.53281540
128RPS6KA30.52885288
129WNK10.52051700
130CSNK1A10.51810003
131CAMK2B0.51649192
132MAP3K20.51101879
133SGK30.49376691
134PRKACA0.49315337
135PRKCA0.47284817
136MAPKAPK20.47197958
137PRKCE0.46575306
138FGR0.45582218
139SGK20.45071178
140KSR20.44153318
141STK38L0.42083011
142LATS20.40387224
143ATR0.40174591
144MAP3K50.40022837
145FYN0.39966476
146MAP3K60.39475986
147PLK30.39222580
148CSNK1E0.38298078
149CDK70.38009843
150PDK10.37485754
151PRKCB0.36297467
152TESK10.36005362
153DYRK1B0.35391709
154ATM0.35380288
155MAPK40.35339896
156CDK140.35286198
157CAMKK20.34594086
158CSNK1D0.34294782
159MKNK10.33586606
160CDK180.33383803
161PASK0.33103709
162MAPK100.32989440
163MAPK120.32498325
164BTK0.32240043
165YES10.31307525
166EPHA30.30230388
167CDK150.30228477
168RPS6KA50.29883091
169MAP3K10.25674191
170PRKDC0.25276518

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.98117573
2Non-homologous end-joining_Homo sapiens_hsa034503.80613006
3Fatty acid elongation_Homo sapiens_hsa000623.22434607
4Mismatch repair_Homo sapiens_hsa034303.07918115
5DNA replication_Homo sapiens_hsa030302.69906882
6Homologous recombination_Homo sapiens_hsa034402.67744111
7Fanconi anemia pathway_Homo sapiens_hsa034602.66262837
8Base excision repair_Homo sapiens_hsa034102.62345250
9Amphetamine addiction_Homo sapiens_hsa050312.46125280
10Cell cycle_Homo sapiens_hsa041102.46088050
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.32016623
12Insulin secretion_Homo sapiens_hsa049112.31982273
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.16202799
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.02153830
15Salivary secretion_Homo sapiens_hsa049701.93746099
16Ether lipid metabolism_Homo sapiens_hsa005651.92345803
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.91708904
18Cyanoamino acid metabolism_Homo sapiens_hsa004601.85625677
19Steroid biosynthesis_Homo sapiens_hsa001001.84183853
20Gastric acid secretion_Homo sapiens_hsa049711.81976782
21Sphingolipid metabolism_Homo sapiens_hsa006001.69467194
22Renin secretion_Homo sapiens_hsa049241.69079481
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.68636839
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.59496798
25Protein export_Homo sapiens_hsa030601.58089951
26Nitrogen metabolism_Homo sapiens_hsa009101.52425688
27Basal transcription factors_Homo sapiens_hsa030221.45240598
28Serotonergic synapse_Homo sapiens_hsa047261.43021882
29Calcium signaling pathway_Homo sapiens_hsa040201.42221383
30Circadian rhythm_Homo sapiens_hsa047101.40409959
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.38692135
32SNARE interactions in vesicular transport_Homo sapiens_hsa041301.38560712
33Linoleic acid metabolism_Homo sapiens_hsa005911.32768814
34ABC transporters_Homo sapiens_hsa020101.29528139
35Olfactory transduction_Homo sapiens_hsa047401.28807848
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.28737868
37Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.28731224
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.27066464
39Oxytocin signaling pathway_Homo sapiens_hsa049211.24275413
40Gap junction_Homo sapiens_hsa045401.23047334
41Cardiac muscle contraction_Homo sapiens_hsa042601.21816338
42Long-term depression_Homo sapiens_hsa047301.21265313
43Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.18544353
44Nucleotide excision repair_Homo sapiens_hsa034201.18398912
45Oocyte meiosis_Homo sapiens_hsa041141.17727422
46Vibrio cholerae infection_Homo sapiens_hsa051101.11308543
47Pancreatic secretion_Homo sapiens_hsa049721.09469644
48Arachidonic acid metabolism_Homo sapiens_hsa005901.08239043
49cAMP signaling pathway_Homo sapiens_hsa040241.05576058
50Alcoholism_Homo sapiens_hsa050341.02571925
51B cell receptor signaling pathway_Homo sapiens_hsa046621.02471366
52Systemic lupus erythematosus_Homo sapiens_hsa053221.02350874
53Sulfur metabolism_Homo sapiens_hsa009201.00597511
54Glutamatergic synapse_Homo sapiens_hsa047240.99755388
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.96885916
56RNA polymerase_Homo sapiens_hsa030200.95322981
57RNA degradation_Homo sapiens_hsa030180.94780499
58Thyroid hormone synthesis_Homo sapiens_hsa049180.94764120
59Primary immunodeficiency_Homo sapiens_hsa053400.93774704
60Estrogen signaling pathway_Homo sapiens_hsa049150.92940771
61Type II diabetes mellitus_Homo sapiens_hsa049300.89772922
62Circadian entrainment_Homo sapiens_hsa047130.89631379
63Caffeine metabolism_Homo sapiens_hsa002320.88869264
64Glutathione metabolism_Homo sapiens_hsa004800.88453645
65cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87646568
66Nicotine addiction_Homo sapiens_hsa050330.87484954
67Histidine metabolism_Homo sapiens_hsa003400.84978700
68GnRH signaling pathway_Homo sapiens_hsa049120.84728708
69Alzheimers disease_Homo sapiens_hsa050100.81893125
70Butanoate metabolism_Homo sapiens_hsa006500.81784324
71Collecting duct acid secretion_Homo sapiens_hsa049660.79405753
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77781094
73Oxidative phosphorylation_Homo sapiens_hsa001900.77240002
74Regulation of autophagy_Homo sapiens_hsa041400.75598397
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.72778818
76Fatty acid biosynthesis_Homo sapiens_hsa000610.72504346
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.72014993
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71092998
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.70784651
80Renal cell carcinoma_Homo sapiens_hsa052110.70575974
81Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.68229087
82GABAergic synapse_Homo sapiens_hsa047270.67730724
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66987708
84Pyrimidine metabolism_Homo sapiens_hsa002400.66866862
85Phototransduction_Homo sapiens_hsa047440.65903408
86Axon guidance_Homo sapiens_hsa043600.64540182
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63426539
88Ovarian steroidogenesis_Homo sapiens_hsa049130.62702322
89Cholinergic synapse_Homo sapiens_hsa047250.60936713
90Parkinsons disease_Homo sapiens_hsa050120.60636031
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60072517
92Taste transduction_Homo sapiens_hsa047420.59874590
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57483922
94Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.57366215
95Dopaminergic synapse_Homo sapiens_hsa047280.56977084
96Inositol phosphate metabolism_Homo sapiens_hsa005620.54653020
97Rheumatoid arthritis_Homo sapiens_hsa053230.54524731
98Viral carcinogenesis_Homo sapiens_hsa052030.54278249
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53562422
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52586169
101Synaptic vesicle cycle_Homo sapiens_hsa047210.51946708
102Cysteine and methionine metabolism_Homo sapiens_hsa002700.51668324
103Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51199096
104Bile secretion_Homo sapiens_hsa049760.50642732
105Cocaine addiction_Homo sapiens_hsa050300.49830332
106Platelet activation_Homo sapiens_hsa046110.49828792
107Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49747992
108Maturity onset diabetes of the young_Homo sapiens_hsa049500.49099945
109Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.48805273
110Vitamin digestion and absorption_Homo sapiens_hsa049770.48521401
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48381171
112Glucagon signaling pathway_Homo sapiens_hsa049220.48240752
113Phospholipase D signaling pathway_Homo sapiens_hsa040720.47834184
114Purine metabolism_Homo sapiens_hsa002300.46794827
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46003343
116Long-term potentiation_Homo sapiens_hsa047200.45367739
117Ras signaling pathway_Homo sapiens_hsa040140.45324032
118Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.45156728
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.44680901
120Pancreatic cancer_Homo sapiens_hsa052120.44539367
121ErbB signaling pathway_Homo sapiens_hsa040120.44296127
122MAPK signaling pathway_Homo sapiens_hsa040100.42755952
123Morphine addiction_Homo sapiens_hsa050320.42615797
124Vitamin B6 metabolism_Homo sapiens_hsa007500.42318859
125Glioma_Homo sapiens_hsa052140.42307520
126Hematopoietic cell lineage_Homo sapiens_hsa046400.42259695
127Glycerolipid metabolism_Homo sapiens_hsa005610.40553114
128Dorso-ventral axis formation_Homo sapiens_hsa043200.39988233
129Drug metabolism - other enzymes_Homo sapiens_hsa009830.39984918
130Mineral absorption_Homo sapiens_hsa049780.39593510
131N-Glycan biosynthesis_Homo sapiens_hsa005100.36446179
132Melanogenesis_Homo sapiens_hsa049160.35325797
133Rap1 signaling pathway_Homo sapiens_hsa040150.35186901
134Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.34529697
135Huntingtons disease_Homo sapiens_hsa050160.33996691
136Choline metabolism in cancer_Homo sapiens_hsa052310.33093482
137Aldosterone synthesis and secretion_Homo sapiens_hsa049250.32586505
138Folate biosynthesis_Homo sapiens_hsa007900.32555338
139Carbohydrate digestion and absorption_Homo sapiens_hsa049730.32478799
140beta-Alanine metabolism_Homo sapiens_hsa004100.31950081
141Peroxisome_Homo sapiens_hsa041460.31142926
142Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.30472262
143Dilated cardiomyopathy_Homo sapiens_hsa054140.29922432
144Phagosome_Homo sapiens_hsa041450.28767610
145Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.28665413
146Fatty acid metabolism_Homo sapiens_hsa012120.28426141
147Pentose phosphate pathway_Homo sapiens_hsa000300.28327938
148mTOR signaling pathway_Homo sapiens_hsa041500.26333401
149Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.16438051
150Thyroid hormone signaling pathway_Homo sapiens_hsa049190.15482103
151Wnt signaling pathway_Homo sapiens_hsa043100.13225776

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