BTC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the epidermal growth factor (EGF) family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the secreted growth factor. A secreted form and a membrane-anchored form of this protein bind to multiple different EGF receptors. This protein promotes pancreatic cell proliferation and insulin secretion, as well as retinal vascular permeability. Mutations in this gene may be associated with type 2 diabetes in human patients. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)9.99874949
2cilium movement (GO:0003341)8.39374133
3epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.33027656
4establishment of skin barrier (GO:0061436)7.63071807
5motile cilium assembly (GO:0044458)6.98768879
6epithelial cilium movement (GO:0003351)6.72790249
7regulation of water loss via skin (GO:0033561)6.50681723
8detection of bacterium (GO:0016045)6.25086836
9detection of other organism (GO:0098543)6.05107475
10axoneme assembly (GO:0035082)5.97739230
11G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)5.58312269
12regulation of interleukin-8 secretion (GO:2000482)4.95822828
13positive regulation of interleukin-8 secretion (GO:2000484)4.76301981
14regulation of cilium movement (GO:0003352)4.71999000
15regulation of type B pancreatic cell apoptotic process (GO:2000674)4.50315556
16left/right pattern formation (GO:0060972)4.36615849
17multicellular organismal water homeostasis (GO:0050891)4.32819169
18gap junction assembly (GO:0016264)4.24491851
19daunorubicin metabolic process (GO:0044597)4.17207706
20polyketide metabolic process (GO:0030638)4.17207706
21doxorubicin metabolic process (GO:0044598)4.17207706
22intestinal epithelial cell development (GO:0060576)4.06853561
23superoxide anion generation (GO:0042554)3.96708089
24desmosome organization (GO:0002934)3.95551857
25pyrimidine-containing compound transmembrane transport (GO:0072531)3.93658282
26primary alcohol catabolic process (GO:0034310)3.87875504
27definitive hemopoiesis (GO:0060216)3.85608185
28retinol metabolic process (GO:0042572)3.82117151
29regulation of cell proliferation involved in kidney development (GO:1901722)3.81830245
30left/right axis specification (GO:0070986)3.80993991
31regulation of natural killer cell differentiation (GO:0032823)3.77773570
32detection of external biotic stimulus (GO:0098581)3.74887211
33regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.71851417
34lipoxygenase pathway (GO:0019372)3.70457163
35purinergic nucleotide receptor signaling pathway (GO:0035590)3.64688666
36keratinocyte development (GO:0003334)3.63946199
37dendritic cell migration (GO:0036336)3.63277289
38water homeostasis (GO:0030104)3.60864275
39terpenoid biosynthetic process (GO:0016114)3.60037082
40one-carbon compound transport (GO:0019755)3.57353399
41auditory receptor cell differentiation (GO:0042491)3.47653947
42regulation of chemokine secretion (GO:0090196)3.43805066
43ventricular system development (GO:0021591)3.41637722
44antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.37476495
45cyclooxygenase pathway (GO:0019371)3.35694222
46establishment of planar polarity (GO:0001736)3.34496672
47establishment of tissue polarity (GO:0007164)3.34496672
48retinal rod cell development (GO:0046548)3.32718181
49sphingoid metabolic process (GO:0046519)3.31979644
50neutrophil activation involved in immune response (GO:0002283)3.27549633
51dendritic cell chemotaxis (GO:0002407)3.26673181
52positive regulation of T cell mediated cytotoxicity (GO:0001916)3.23485816
53cilium organization (GO:0044782)3.21332908
54ethanol metabolic process (GO:0006067)3.19193186
55microtubule bundle formation (GO:0001578)3.18948823
56keratinization (GO:0031424)3.11708222
57phospholipid scrambling (GO:0017121)3.11041265
58regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.08877120
59detection of biotic stimulus (GO:0009595)3.08140453
60positive regulation of vasodilation (GO:0045909)3.08063580
61O-glycan processing (GO:0016266)3.08039877
62calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.07337971
63primary alcohol metabolic process (GO:0034308)3.06881020
64vitamin transmembrane transport (GO:0035461)3.06361488
65positive regulation of T-helper 1 type immune response (GO:0002827)3.04223001
66cilium assembly (GO:0042384)3.04011390
67keratinocyte differentiation (GO:0030216)3.02370209
68dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.00492344
69platelet dense granule organization (GO:0060155)3.00055031
70positive regulation of chemokine secretion (GO:0090197)2.93808834
71T-helper 1 type immune response (GO:0042088)2.93287130
72glomerular epithelial cell development (GO:0072310)2.92833884
73Leydig cell differentiation (GO:0033327)2.92327253
74negative regulation of humoral immune response (GO:0002921)2.89831324
75G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.89169043
76glutathione derivative metabolic process (GO:1901685)2.87750728
77glutathione derivative biosynthetic process (GO:1901687)2.87750728
78regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)2.82625064
79bundle of His cell to Purkinje myocyte communication (GO:0086069)2.81648256
80negative regulation of gluconeogenesis (GO:0045721)2.81241352
81regulation of RIG-I signaling pathway (GO:0039535)2.80623469
82positive regulation of glomerulus development (GO:0090193)2.80036652
83keratinocyte proliferation (GO:0043616)2.79872906
84hepatocyte apoptotic process (GO:0097284)2.79285009
85magnesium ion transport (GO:0015693)2.77865845
86protein localization to cilium (GO:0061512)2.77119728
87signal peptide processing (GO:0006465)2.75032171
88sphingomyelin metabolic process (GO:0006684)2.74719148
89neutrophil activation (GO:0042119)2.74587985
90aminoglycoside antibiotic metabolic process (GO:0030647)2.74478058
91regulation of T cell mediated cytotoxicity (GO:0001914)2.73690115
92positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.73503772
93regulation of natural killer cell activation (GO:0032814)2.72950280
94interleukin-6-mediated signaling pathway (GO:0070102)2.71641134
95retinoic acid metabolic process (GO:0042573)2.68450942
96lung epithelium development (GO:0060428)2.67550251
97long-chain fatty acid biosynthetic process (GO:0042759)2.67254844
98CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.67196914
99T-helper cell differentiation (GO:0042093)2.67196914
100response to interferon-beta (GO:0035456)2.66775477
101positive regulation of alpha-beta T cell proliferation (GO:0046641)2.65909584
102adenosine metabolic process (GO:0046085)2.65788902
103hepatocyte differentiation (GO:0070365)2.65254241
104smooth muscle tissue development (GO:0048745)2.62659337
105regulation of T-helper 1 type immune response (GO:0002825)2.62313577
106positive regulation of transforming growth factor beta production (GO:0071636)2.62004061
107production of molecular mediator involved in inflammatory response (GO:0002532)2.60568004
108cellular response to interferon-beta (GO:0035458)2.59898780
109positive regulation of p38MAPK cascade (GO:1900745)2.59838539
110intraciliary transport (GO:0042073)2.59838368
111positive regulation of cellular amide metabolic process (GO:0034250)2.58126595
112cellular component assembly involved in morphogenesis (GO:0010927)2.56480571
113regulation of activation of Janus kinase activity (GO:0010533)2.56346195
114positive regulation of antigen processing and presentation (GO:0002579)2.52941731
115glandular epithelial cell differentiation (GO:0002067)2.50481774
116regulation of glomerulus development (GO:0090192)2.50295261
117regulation of transforming growth factor beta1 production (GO:0032908)2.46425284
118negative regulation of keratinocyte proliferation (GO:0010839)2.45834319
119epithelial cell maturation (GO:0002070)2.45792998
120surfactant homeostasis (GO:0043129)2.44536575
121tight junction assembly (GO:0070830)2.43974278
122polyol transport (GO:0015791)2.43331388
123regulation of phospholipase A2 activity (GO:0032429)2.43113480
124cilium morphogenesis (GO:0060271)2.42747922
125positive regulation of T cell migration (GO:2000406)2.42237090
126sphingosine metabolic process (GO:0006670)2.41964325
127regulation of vasodilation (GO:0042312)2.40980393
128transcytosis (GO:0045056)2.40959165
129negative regulation of viral genome replication (GO:0045071)2.40879551
130histamine secretion (GO:0001821)2.40534266
131positive regulation of respiratory burst (GO:0060267)2.40324530
132regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.39814198
133granulocyte activation (GO:0036230)2.39721921
134regulation of transforming growth factor beta production (GO:0071634)2.39580276
135nephron tubule formation (GO:0072079)2.39537652
136positive regulation of protein autophosphorylation (GO:0031954)2.38628478
137regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)2.38485585
138cellular response to exogenous dsRNA (GO:0071360)2.38406443
139cell projection assembly (GO:0030031)2.38234174
140hair cell differentiation (GO:0035315)2.38034664
141response to peptidoglycan (GO:0032494)2.36383435
142inner ear receptor cell differentiation (GO:0060113)2.36072922
143UDP-N-acetylglucosamine metabolic process (GO:0006047)2.35224045
144ribosomal small subunit assembly (GO:0000028)2.34672766
145ethanol oxidation (GO:0006069)2.34326974
146regulation of glomerular filtration (GO:0003093)2.34237254
147positive regulation of keratinocyte differentiation (GO:0045618)2.34026058
148purinergic receptor signaling pathway (GO:0035587)2.33988359
149regulation of interleukin-5 production (GO:0032674)2.33734036
150positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.33199073
151retinal metabolic process (GO:0042574)2.32476118
152energy homeostasis (GO:0097009)2.32081242
153early endosome to late endosome transport (GO:0045022)2.32069582
154regulation of microtubule-based movement (GO:0060632)2.32013775
155negative regulation of complement activation (GO:0045916)2.31979966
156diterpenoid biosynthetic process (GO:0016102)2.31178622
157positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.30924577
158cell-cell junction assembly (GO:0007043)2.30633539
159positive regulation of actin filament depolymerization (GO:0030836)2.30418140
160megakaryocyte development (GO:0035855)2.29501509
161regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.29400976
162regulation of metalloenzyme activity (GO:0048552)2.29347653
163positive regulation of defense response to virus by host (GO:0002230)2.29175782
164organ formation (GO:0048645)2.28581969
165ER overload response (GO:0006983)2.27975753
166regulation of mesenchymal cell apoptotic process (GO:2001053)2.27882916
167positive regulation of interleukin-1 beta secretion (GO:0050718)2.27322052
168regulation of transmission of nerve impulse (GO:0051969)2.26975686
169chemical homeostasis within a tissue (GO:0048875)2.26337527
170cellular response to type I interferon (GO:0071357)2.26288318
171type I interferon signaling pathway (GO:0060337)2.26288318
172phospholipid efflux (GO:0033700)2.26249999
173response to type I interferon (GO:0034340)2.25809615
174regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.25732031
175alpha-beta T cell differentiation involved in immune response (GO:0002293)2.25443038
176alpha-beta T cell activation involved in immune response (GO:0002287)2.25443038
177T cell differentiation involved in immune response (GO:0002292)2.25443038
178detection of molecule of bacterial origin (GO:0032490)2.24643105
179positive regulation of adaptive immune response (GO:0002821)2.24212377
180regulation of T cell mediated immunity (GO:0002709)2.23498291
181endocrine pancreas development (GO:0031018)2.23341731
182leukocyte aggregation (GO:0070486)2.23186947
183regulation of T cell chemotaxis (GO:0010819)2.22965862
184positive regulation of glycoprotein metabolic process (GO:1903020)2.22577171
185axonemal dynein complex assembly (GO:0070286)10.7713782

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.90379154
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.88532494
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.32767736
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.56697760
5TRIM28_21343339_ChIP-Seq_HEK293_Human3.43668734
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.35684157
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.13076826
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.91746135
9* IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.82031302
10* IRF8_21731497_ChIP-ChIP_J774_Mouse2.68195151
11ESR1_20079471_ChIP-ChIP_T-47D_Human2.65681739
12SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.55256423
13STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.29311960
14EGR1_23403033_ChIP-Seq_LIVER_Mouse2.27624811
15PCGF2_27294783_Chip-Seq_ESCs_Mouse2.21810492
16AHR_22903824_ChIP-Seq_MCF-7_Human2.11785089
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.07368124
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.05062270
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.03705548
20* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.01057764
21CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.99035874
22PCGF2_27294783_Chip-Seq_NPCs_Mouse1.97437623
23SUZ12_27294783_Chip-Seq_NPCs_Mouse1.96808267
24FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.94594456
25GATA2_21666600_ChIP-Seq_HMVEC_Human1.94481800
26SMAD_19615063_ChIP-ChIP_OVARY_Human1.94194979
27NFE2_27457419_Chip-Seq_LIVER_Mouse1.93037573
28* TP63_23658742_ChIP-Seq_EP156T_Human1.92208775
29PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.91655446
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.90306840
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.90217315
32FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.85981788
33FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.85583429
34ESR1_21235772_ChIP-Seq_MCF-7_Human1.83716572
35ARNT_22903824_ChIP-Seq_MCF-7_Human1.81465175
36HIF1A_21447827_ChIP-Seq_MCF-7_Human1.77998860
37* FOXO3_23340844_ChIP-Seq_DLD1_Human1.76739802
38ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.73994325
39PPAR_26484153_Chip-Seq_NCI-H1993_Human1.72294684
40SOX2_27498859_Chip-Seq_STOMACH_Mouse1.72096636
41ESR2_21235772_ChIP-Seq_MCF-7_Human1.70480665
42SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.69624052
43SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.69624052
44SCL_19346495_ChIP-Seq_HPC-7_Human1.67676648
45EZH2_27294783_Chip-Seq_NPCs_Mouse1.66074444
46* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.59623117
47CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.58916703
48* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.57863966
49* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.56672174
50P63_26484246_Chip-Seq_KERATINOCYTES_Human1.56522949
51GATA3_24758297_ChIP-Seq_MCF-7_Human1.56510480
52RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.53220162
53GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52790330
54TP53_18474530_ChIP-ChIP_U2OS_Human1.51725955
55* FOXA1_25552417_ChIP-Seq_VCAP_Human1.51723116
56SUZ12_18555785_Chip-Seq_ESCs_Mouse1.47299354
57* SOX2_20726797_ChIP-Seq_SW620_Human1.46056254
58STAT3_18555785_Chip-Seq_ESCs_Mouse1.43949087
59CDX2_22108803_ChIP-Seq_LS180_Human1.41827776
60P53_22387025_ChIP-Seq_ESCs_Mouse1.40759529
61* IRF8_27001747_Chip-Seq_BMDM_Mouse1.39082203
62NOTCH1_21737748_ChIP-Seq_TLL_Human1.38701951
63SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.38322350
64EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.37592548
65STAT4_19710469_ChIP-ChIP_TH1__Mouse1.36141446
66ELF1_17652178_ChIP-ChIP_JURKAT_Human1.35559252
67NMYC_18555785_Chip-Seq_ESCs_Mouse1.35492581
68SOX9_24532713_ChIP-Seq_HFSC_Mouse1.33877451
69E2F1_18555785_Chip-Seq_ESCs_Mouse1.29556510
70TP53_16413492_ChIP-PET_HCT116_Human1.28511768
71MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.28100432
72PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28020925
73RUNX1_27457419_Chip-Seq_LIVER_Mouse1.26440288
74SMAD4_21799915_ChIP-Seq_A2780_Human1.26316349
75PU1_27457419_Chip-Seq_LIVER_Mouse1.26082701
76TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25684303
77POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25140042
78EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.24525563
79LXR_22158963_ChIP-Seq_LIVER_Mouse1.24475459
80GBX2_23144817_ChIP-Seq_PC3_Human1.24428841
81EP300_21415370_ChIP-Seq_HL-1_Mouse1.23978946
82RUNX_20019798_ChIP-Seq_JUKART_Human1.23565289
83* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.21491008
84NANOG_18555785_Chip-Seq_ESCs_Mouse1.21194603
85OCT4_18555785_Chip-Seq_ESCs_Mouse1.21092005
86RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.21005213
87EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.19615889
88ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.19293870
89TAL1_26923725_Chip-Seq_HPCs_Mouse1.19162307
90LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.19023187
91ZFX_18555785_Chip-Seq_ESCs_Mouse1.18289832
92P300_18555785_Chip-Seq_ESCs_Mouse1.17913032
93CMYC_18555785_Chip-Seq_ESCs_Mouse1.17283889
94KAP1_22055183_ChIP-Seq_ESCs_Mouse1.16545836
95GATA4_25053715_ChIP-Seq_YYC3_Human1.16515461
96* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15853050
97NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15827919
98FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.15797177
99SMAD1_18555785_Chip-Seq_ESCs_Mouse1.15479525
100FUS_26573619_Chip-Seq_HEK293_Human1.14800778
101* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.14330277
102* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14226665
103RXR_22108803_ChIP-Seq_LS180_Human1.14121705
104BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13958047
105CTCF_18555785_Chip-Seq_ESCs_Mouse1.13184976
106CRX_20693478_ChIP-Seq_RETINA_Mouse1.12423270
107SOX2_18555785_Chip-Seq_ESCs_Mouse1.12175516
108CJUN_26792858_Chip-Seq_BT549_Human1.11538386
109CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.11143088
110* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10832700
111KLF5_25053715_ChIP-Seq_YYC3_Human1.10262417
112VDR_22108803_ChIP-Seq_LS180_Human1.10152889
113ESRRB_18555785_Chip-Seq_ESCs_Mouse1.09925120
114KLF4_18555785_Chip-Seq_ESCs_Mouse1.09756418
115CDX2_20551321_ChIP-Seq_CACO-2_Human1.08560098
116PIAS1_25552417_ChIP-Seq_VCAP_Human1.08431973
117RXR_22158963_ChIP-Seq_LIVER_Mouse1.07802477
118IRF1_19129219_ChIP-ChIP_H3396_Human1.07187266
119SMAD3_21741376_ChIP-Seq_HESCs_Human1.05518147
120CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05027790
121SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.04842642
122CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.04819344
123GATA6_25053715_ChIP-Seq_YYC3_Human1.04594978
124FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04243433
125TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03579298
126SMAD3_21741376_ChIP-Seq_EPCs_Human1.03540084
127BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.02780013
128CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02671298
129MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02430324
130NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.02322202
131KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.01367246
132ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01146995
133CTNNB1_20460455_ChIP-Seq_HCT116_Human1.01088632
134IGF1R_20145208_ChIP-Seq_DFB_Human0.99938300
135RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.99788632
136* TCF4_22108803_ChIP-Seq_LS180_Human0.99243520
137GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.99035198
138ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98915067
139OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98658442
140AR_25329375_ChIP-Seq_VCAP_Human0.97755650
141FOXM1_26456572_ChIP-Seq_MCF-7_Human0.97108151
142CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.96946998
143* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.96246714
144* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.96246714
145OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96070763
146ER_23166858_ChIP-Seq_MCF-7_Human0.91630399
147KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.89035105
148BRD4_25478319_ChIP-Seq_HGPS_Human0.88017036
149SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.87775729
150NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.87368801
151FOXA2_19822575_ChIP-Seq_HepG2_Human0.86766474
152STAT3_23295773_ChIP-Seq_U87_Human0.86300234
153* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.86294021
154PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.86263251
155PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.85407406
156P300_19829295_ChIP-Seq_ESCs_Human0.84873401
157CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.83708211
158SOX2_19829295_ChIP-Seq_ESCs_Human0.82351181
159NANOG_19829295_ChIP-Seq_ESCs_Human0.82351181
160BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.81926379
161ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.81908807
162SMAD4_21741376_ChIP-Seq_EPCs_Human0.81775031
163PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.80551458
164SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.80387511

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009780_abnormal_chondrocyte_physiolo4.99446134
2MP0003941_abnormal_skin_development4.74429945
3MP0002796_impaired_skin_barrier4.03404037
4MP0010234_abnormal_vibrissa_follicle3.51474475
5MP0005451_abnormal_body_composition3.17471542
6MP0008875_abnormal_xenobiotic_pharmacok3.16689519
7MP0004381_abnormal_hair_follicle3.06039999
8MP0003724_increased_susceptibility_to2.68526315
9MP0009785_altered_susceptibility_to2.62481944
10MP0004782_abnormal_surfactant_physiolog2.61273103
11MP0002132_abnormal_respiratory_system2.59815144
12MP0005501_abnormal_skin_physiology2.58008108
13MP0005275_abnormal_skin_tensile2.51604714
14MP0002009_preneoplasia2.51513286
15MP0001835_abnormal_antigen_presentation2.51028001
16MP0002148_abnormal_hypersensitivity_rea2.41739858
17MP0002060_abnormal_skin_morphology2.34993313
18MP0002139_abnormal_hepatobiliary_system2.30335290
19MP0008004_abnormal_stomach_pH2.26483247
20MP0001188_hyperpigmentation2.18922902
21MP0004947_skin_inflammation2.15077674
22MP0000013_abnormal_adipose_tissue2.14777806
23MP0003191_abnormal_cellular_cholesterol2.08843275
24MP0005671_abnormal_response_to1.95944113
25MP0003011_delayed_dark_adaptation1.93229447
26MP0002254_reproductive_system_inflammat1.92877117
27MP0002876_abnormal_thyroid_physiology1.91566812
28MP0002909_abnormal_adrenal_gland1.89261584
29MP0000566_synostosis1.83570817
30MP0005248_abnormal_Harderian_gland1.80711557
31MP0010678_abnormal_skin_adnexa1.80279531
32MP0001216_abnormal_epidermal_layer1.72289310
33MP0005025_abnormal_response_to1.72034544
34MP0000383_abnormal_hair_follicle1.69270083
35MP0004043_abnormal_pH_regulation1.68298724
36MP0003283_abnormal_digestive_organ1.64741878
37MP0010771_integument_phenotype1.64695051
38MP0003436_decreased_susceptibility_to1.61830697
39MP0002098_abnormal_vibrissa_morphology1.61441562
40MP0002277_abnormal_respiratory_mucosa1.59995292
41MP0009697_abnormal_copulation1.59184250
42MP0002160_abnormal_reproductive_system1.53881021
43MP0002653_abnormal_ependyma_morphology1.53775790
44MP0009764_decreased_sensitivity_to1.48745189
45MP0005646_abnormal_pituitary_gland1.47000474
46MP0000462_abnormal_digestive_system1.46806475
47MP0005000_abnormal_immune_tolerance1.45221351
48MP0002419_abnormal_innate_immunity1.44470418
49MP0001944_abnormal_pancreas_morphology1.43200273
50MP0005220_abnormal_exocrine_pancreas1.39668809
51MP0005075_abnormal_melanosome_morpholog1.39150806
52MP0003763_abnormal_thymus_physiology1.38681655
53MP0004272_abnormal_basement_membrane1.36438543
54MP0002006_tumorigenesis1.36244493
55MP0003453_abnormal_keratinocyte_physiol1.33034215
56MP0001756_abnormal_urination1.32838368
57MP0009379_abnormal_foot_pigmentation1.32657945
58MP0006054_spinal_hemorrhage1.32177839
59MP0001191_abnormal_skin_condition1.30513389
60MP0003943_abnormal_hepatobiliary_system1.30513016
61MP0005084_abnormal_gallbladder_morpholo1.26399840
62MP0003186_abnormal_redox_activity1.26088423
63MP0006292_abnormal_olfactory_placode1.25250155
64MP0010155_abnormal_intestine_physiology1.24987253
65MP0003950_abnormal_plasma_membrane1.24076685
66MP0002138_abnormal_hepatobiliary_system1.24068430
67MP0002166_altered_tumor_susceptibility1.23023335
68MP0005647_abnormal_sex_gland1.22985023
69MP0001346_abnormal_lacrimal_gland1.21766477
70MP0006082_CNS_inflammation1.21765997
71MP0002452_abnormal_antigen_presenting1.18576162
72MP0005464_abnormal_platelet_physiology1.18268155
73MP0001986_abnormal_taste_sensitivity1.17750540
74MP0003195_calcinosis1.17164581
75MP0010352_gastrointestinal_tract_polyps1.16017758
76MP0002877_abnormal_melanocyte_morpholog1.14817393
77MP0009643_abnormal_urine_homeostasis1.14460491
78MP0002723_abnormal_immune_serum1.14435641
79MP0005164_abnormal_response_to1.14297597
80MP0003878_abnormal_ear_physiology1.11881154
81MP0005377_hearing/vestibular/ear_phenot1.11881154
82MP0001819_abnormal_immune_cell1.11764656
83MP0002638_abnormal_pupillary_reflex1.11494878
84MP0002420_abnormal_adaptive_immunity1.11161193
85MP0000003_abnormal_adipose_tissue1.09686994
86MP0001790_abnormal_immune_system1.09405731
87MP0005387_immune_system_phenotype1.09405731
88MP0003136_yellow_coat_color1.09144052
89MP0000762_abnormal_tongue_morphology1.08638379
90MP0001800_abnormal_humoral_immune1.08293034
91MP0000465_gastrointestinal_hemorrhage1.07930277
92MP0009333_abnormal_splenocyte_physiolog1.05824140
93MP0004019_abnormal_vitamin_homeostasis1.05805735
94MP0004133_heterotaxia1.04885919
95MP0005166_decreased_susceptibility_to1.04148759
96MP0005408_hypopigmentation1.03474618
97MP0000685_abnormal_immune_system1.02631836
98MP0000681_abnormal_thyroid_gland1.02549064
99MP0000858_altered_metastatic_potential1.02262467
100MP0000627_abnormal_mammary_gland1.01890577
101MP0002837_dystrophic_cardiac_calcinosis0.99910538
102MP0009931_abnormal_skin_appearance0.99825501
103MP0001765_abnormal_ion_homeostasis0.99508706
104MP0000647_abnormal_sebaceous_gland0.99354851
105MP0002693_abnormal_pancreas_physiology0.97832268
106MP0001881_abnormal_mammary_gland0.97804948
107MP0000427_abnormal_hair_cycle0.96989831
108MP0005023_abnormal_wound_healing0.96135358
109MP0002095_abnormal_skin_pigmentation0.95932996
110MP0005165_increased_susceptibility_to0.91879767
111MP0005174_abnormal_tail_pigmentation0.90670162
112MP0002168_other_aberrant_phenotype0.89837868
113MP0001845_abnormal_inflammatory_respons0.89324254
114MP0002136_abnormal_kidney_physiology0.88515153
115MP0004147_increased_porphyrin_level0.87888582
116MP0002163_abnormal_gland_morphology0.87491560
117MP0005332_abnormal_amino_acid0.86512306
118MP0000490_abnormal_crypts_of0.85781993
119MP0001853_heart_inflammation0.84494638
120MP0001873_stomach_inflammation0.84230598
121MP0000377_abnormal_hair_follicle0.82536665
122MP0002896_abnormal_bone_mineralization0.82488401
123MP0001501_abnormal_sleep_pattern0.82104337
124MP0010329_abnormal_lipoprotein_level0.81015669
125MP0001533_abnormal_skeleton_physiology0.79849601
126MP0005197_abnormal_uvea_morphology0.79110429
127MP0001177_atelectasis0.79010208
128MP0001764_abnormal_homeostasis0.78495658
129MP0005253_abnormal_eye_physiology0.77299272
130MP0003252_abnormal_bile_duct0.76994680
131MP0001984_abnormal_olfaction0.76854006
132MP0000372_irregular_coat_pigmentation0.75752912
133MP0005395_other_phenotype0.75586284
134MP0004484_altered_response_of0.75248938
135MP0001879_abnormal_lymphatic_vessel0.75132264
136MP0008469_abnormal_protein_level0.75128235
137MP0002405_respiratory_system_inflammati0.74969610
138MP0003936_abnormal_reproductive_system0.73832632
139MP0009384_cardiac_valve_regurgitation0.73611002
140MP0000716_abnormal_immune_system0.71632622
141MP0003045_fibrosis0.70954680
142MP0000579_abnormal_nail_morphology0.69806302
143MP0000538_abnormal_urinary_bladder0.69784349
144MP0009765_abnormal_xenobiotic_induced0.69361273
145MP0002998_abnormal_bone_remodeling0.69334712
146MP0003656_abnormal_erythrocyte_physiolo0.68621406
147MP0000367_abnormal_coat/_hair0.68559246
148MP0002332_abnormal_exercise_endurance0.68416247
149MP0010386_abnormal_urinary_bladder0.67559404
150MP0005375_adipose_tissue_phenotype0.67068932
151MP0000428_abnormal_craniofacial_morphol0.66291151
152MP0005636_abnormal_mineral_homeostasis0.66220079
153MP0002282_abnormal_trachea_morphology0.65783955
154MP0004264_abnormal_extraembryonic_tissu0.65553259
155MP0001270_distended_abdomen0.65344458
156MP0003690_abnormal_glial_cell0.65180090
157MP0001664_abnormal_digestion0.64527255
158MP0001666_abnormal_nutrient_absorption0.64287888
159MP0001324_abnormal_eye_pigmentation0.62704083
160MP0002398_abnormal_bone_marrow0.62503297
161MP0005257_abnormal_intraocular_pressure0.61899300
162MP0001243_abnormal_dermal_layer0.61843445

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.16706771
2Dynein arm defect of respiratory motile cilia (HP:0012255)8.44440041
3Absent/shortened dynein arms (HP:0200106)8.44440041
4Abnormal respiratory motile cilium physiology (HP:0012261)7.93091742
5Abnormal ciliary motility (HP:0012262)7.92741617
6Abnormal respiratory epithelium morphology (HP:0012253)7.92540501
7Abnormal respiratory motile cilium morphology (HP:0005938)7.92540501
8Rhinitis (HP:0012384)7.23151550
9Chronic bronchitis (HP:0004469)5.98529895
10Bronchiectasis (HP:0002110)5.32938538
11Nasal polyposis (HP:0100582)4.54500150
12Congenital ichthyosiform erythroderma (HP:0007431)4.40262328
13Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.38653564
14Lip pit (HP:0100267)3.89844214
15Eczematoid dermatitis (HP:0000976)3.68876679
16Abnormality of the nasal mucosa (HP:0000433)3.60414525
17Hyperactive renin-angiotensin system (HP:0000841)3.59541584
18Gangrene (HP:0100758)3.37056364
19Onycholysis (HP:0001806)3.28906365
20Renal cortical cysts (HP:0000803)3.28166001
21Ectropion (HP:0000656)3.27377483
22Distal lower limb muscle weakness (HP:0009053)3.25480947
23Bronchitis (HP:0012387)3.17712808
24Increased IgE level (HP:0003212)3.09888132
25Alveolar cell carcinoma (HP:0006519)3.04199088
26Tubulointerstitial nephritis (HP:0001970)3.02925463
27Erythema (HP:0010783)2.95225843
28Prostate neoplasm (HP:0100787)2.86720029
29Myositis (HP:0100614)2.81856470
30Pruritus (HP:0000989)2.76138559
31Chromosomal breakage induced by crosslinking agents (HP:0003221)2.72629365
32Recurrent abscess formation (HP:0002722)2.72475503
33Glucose intolerance (HP:0000833)2.71517508
34Infertility (HP:0000789)2.62624169
35Hyperkalemia (HP:0002153)2.61361013
36Erythroderma (HP:0001019)2.61235453
37Retrobulbar optic neuritis (HP:0100654)2.59684558
38Optic neuritis (HP:0100653)2.59684558
39Orchitis (HP:0100796)2.56657220
40Occipital encephalocele (HP:0002085)2.53924404
41Parakeratosis (HP:0001036)2.53199364
42Renal salt wasting (HP:0000127)2.53145533
43Reduced antithrombin III activity (HP:0001976)2.52226909
44Corneal erosion (HP:0200020)2.51503895
45Recurrent sinusitis (HP:0011108)2.50058062
46Type I transferrin isoform profile (HP:0003642)2.47869356
47Chronic sinusitis (HP:0011109)2.44431628
48Abnormality of the renal cortex (HP:0011035)2.42856460
49Type 2 muscle fiber atrophy (HP:0003554)2.42625945
50Pancreatic fibrosis (HP:0100732)2.41223754
51Plantar hyperkeratosis (HP:0007556)2.40801404
52Neoplasm of the tracheobronchial system (HP:0100552)2.40372238
53Abnormality of permanent molar morphology (HP:0011071)2.39149270
54Abnormality of the dental root (HP:0006486)2.39149270
55Taurodontia (HP:0000679)2.39149270
56Chromsome breakage (HP:0040012)2.38339933
57Recurrent otitis media (HP:0000403)2.37158745
58Male infertility (HP:0003251)2.33360386
59Stomach cancer (HP:0012126)2.31078766
60Decreased circulating renin level (HP:0003351)2.28915634
61Patchy hypopigmentation of hair (HP:0011365)2.28149129
62Recurrent bacterial skin infections (HP:0005406)2.26733745
63Abnormality of the renal collecting system (HP:0004742)2.20927015
64True hermaphroditism (HP:0010459)2.19449874
65Median cleft lip (HP:0000161)2.17337611
66Periodontitis (HP:0000704)2.16853096
67Abnormality of molar morphology (HP:0011070)2.16565346
68Abnormality of molar (HP:0011077)2.16565346
69Petechiae (HP:0000967)2.16038211
70Abnormality of the dental pulp (HP:0006479)2.15477289
71White forelock (HP:0002211)2.15409535
72Conical tooth (HP:0000698)2.12138802
73Abnormal sex determination (HP:0012244)2.11894054
74Sex reversal (HP:0012245)2.11894054
75Palmar hyperkeratosis (HP:0010765)2.11789982
76Palmoplantar hyperkeratosis (HP:0000972)2.11744999
77Muscle fiber atrophy (HP:0100295)2.10048872
78Dry hair (HP:0011359)2.09947877
79Abnormal hair laboratory examination (HP:0003328)2.09265578
80Hyponatremia (HP:0002902)2.08869144
81Duplicated collecting system (HP:0000081)2.08397950
82Abnormality of sodium homeostasis (HP:0010931)2.07612922
83Elevated erythrocyte sedimentation rate (HP:0003565)2.07156037
84Sensory axonal neuropathy (HP:0003390)2.05940574
85Pili torti (HP:0003777)2.04827100
86Curly hair (HP:0002212)2.03210834
87Right ventricular cardiomyopathy (HP:0011663)2.00253845
88Hypotrichosis (HP:0001006)1.99819307
89Conjunctival hamartoma (HP:0100780)1.99755563
90Pigmentary retinal degeneration (HP:0001146)1.99683372
91Furrowed tongue (HP:0000221)1.98802712
92Pustule (HP:0200039)1.98363504
93Hypothermia (HP:0002045)1.97777881
94Alopecia of scalp (HP:0002293)1.96525677
95Abnormality of the axillary hair (HP:0100134)1.96522053
96Abnormality of secondary sexual hair (HP:0009888)1.96522053
97Congenital, generalized hypertrichosis (HP:0004540)1.96460889
98Cone-rod dystrophy (HP:0000548)1.96416278
99Abnormality of the nasal septum (HP:0000419)1.95473098
100Abnormality of the prostate (HP:0008775)1.94882961
101Dehydration (HP:0001944)1.94634340
102Thrombocytosis (HP:0001894)1.93886973
103Hypohidrosis (HP:0000966)1.93854482
104Popliteal pterygium (HP:0009756)1.92099242
105Hypergammaglobulinemia (HP:0010702)1.91935424
106Keratoconjunctivitis sicca (HP:0001097)1.91215839
107Recurrent cutaneous fungal infections (HP:0011370)1.91012836
108Chronic mucocutaneous candidiasis (HP:0002728)1.91012836
109Vascular calcification (HP:0004934)1.90874129
110Fair hair (HP:0002286)1.90670626
111Menstrual irregularities (HP:0000858)1.89662857
112Metaphyseal dysplasia (HP:0100255)1.89340556
113Insulin-resistant diabetes mellitus (HP:0000831)1.88887127
114Generalized aminoaciduria (HP:0002909)1.88003967
115Aplasia cutis congenita (HP:0001057)1.87426467
116Short nail (HP:0001799)1.83822959
117Woolly hair (HP:0002224)1.82731314
118Reticulocytopenia (HP:0001896)1.82329186
119Vacuolated lymphocytes (HP:0001922)1.82002376
120Cystic liver disease (HP:0006706)1.81528791
121Sepsis (HP:0100806)1.80624239
122Sparse eyelashes (HP:0000653)1.80395583
123Chronic hepatic failure (HP:0100626)1.80078627
124Molar tooth sign on MRI (HP:0002419)1.79676734
125Abnormality of midbrain morphology (HP:0002418)1.79676734
126Increased IgM level (HP:0003496)1.79423237
127Prolonged bleeding time (HP:0003010)1.79359471
128Abnormality of aromatic amino acid family metabolism (HP:0004338)1.79349113
129Malignant hyperthermia (HP:0002047)1.79341769
130Xerostomia (HP:0000217)1.77184935
131Tetraparesis (HP:0002273)1.77154467
132Pancreatic cysts (HP:0001737)1.76593192
133Malnutrition (HP:0004395)1.76117867
134Keratoconjunctivitis (HP:0001096)1.76113713
135Medial flaring of the eyebrow (HP:0010747)1.75944517
136Hypoplasia of dental enamel (HP:0006297)1.75783183
137Abnormality of the preputium (HP:0100587)1.75560033
138Abnormal glucose tolerance (HP:0001952)1.74698777
139Abnormality of renin-angiotensin system (HP:0000847)1.74635383
140Weak cry (HP:0001612)1.73938415
141Absent rod-and cone-mediated responses on ERG (HP:0007688)1.73529021
142Fragile nails (HP:0001808)1.72529549
143Male pseudohermaphroditism (HP:0000037)1.71816616
144Cheilitis (HP:0100825)1.71180660
145Purpura (HP:0000979)1.70040692
146Recurrent gram-negative bacterial infections (HP:0005420)1.69514482
147Hyperaldosteronism (HP:0000859)1.69313478
14811 pairs of ribs (HP:0000878)1.69112221
149Premature loss of primary teeth (HP:0006323)1.68941422
150Clubbing of toes (HP:0100760)1.68504246
151Conjugated hyperbilirubinemia (HP:0002908)1.68143422
152Adrenal hypoplasia (HP:0000835)1.67966511
153Anhidrosis (HP:0000970)1.66909193
154Duplication of thumb phalanx (HP:0009942)1.66655319
155Acanthosis nigricans (HP:0000956)1.66576096
156Aplasia involving bones of the extremities (HP:0009825)1.65369849
157Aplasia involving bones of the upper limbs (HP:0009823)1.65369849
158Aplasia of the phalanges of the hand (HP:0009802)1.65369849
159Focal segmental glomerulosclerosis (HP:0000097)1.63751820
160IgG deficiency (HP:0004315)1.63360931
161Optic nerve coloboma (HP:0000588)1.62998170
162Skin rash (HP:0000988)1.62865939
163Recurrent skin infections (HP:0001581)1.62661900
164Prolonged neonatal jaundice (HP:0006579)1.62259312
165Abnormality of chloride homeostasis (HP:0011422)1.61278850
166Abnormal rod and cone electroretinograms (HP:0008323)1.60925097
167Congenital sensorineural hearing impairment (HP:0008527)1.60508459
168Hamartoma of the eye (HP:0010568)1.60468911
169Growth hormone excess (HP:0000845)1.59910095
170Gingivitis (HP:0000230)1.59087726
171Cardiovascular calcification (HP:0011915)1.58350443
172Osteolytic defects of the hand bones (HP:0009699)1.58090075
173Osteolytic defects of the phalanges of the hand (HP:0009771)1.58090075
174Abnormality of the distal phalanges of the toes (HP:0010182)1.55862090
175Tubular atrophy (HP:0000092)1.55748912
176Mucopolysacchariduria (HP:0008155)1.55375746
177Urinary glycosaminoglycan excretion (HP:0003541)1.55375746
178Nephronophthisis (HP:0000090)1.53131146
179Papillary thyroid carcinoma (HP:0002895)1.53116672
180Hyporeflexia of lower limbs (HP:0002600)1.52479662
181Congenital primary aphakia (HP:0007707)1.50495791
182Abnormality of the renal medulla (HP:0100957)1.49761230

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K143.53134136
2IRAK32.93611014
3MET2.71245408
4TXK2.57557918
5PRPF4B2.57485668
6NEK92.52270174
7TESK12.51741788
8IRAK42.39847484
9ZAK2.27151112
10MST42.08412205
11CASK1.98258220
12BMPR21.97991194
13STK241.92152695
14TRPM71.88283648
15NEK61.84824315
16EPHA21.78323721
17IKBKE1.75805415
18ERBB31.75597313
19STK38L1.72288813
20STK161.67710096
21MKNK11.66151559
22MAP3K21.65353783
23TEC1.63789714
24EIF2AK21.60411797
25IKBKB1.56846787
26PIM21.54790999
27NUAK11.53704833
28STK391.53569126
29GRK11.49617671
30MAP3K121.45822031
31MST1R1.45678016
32CHUK1.42275877
33PIK3CG1.41220681
34MAP3K91.40364900
35MKNK21.39292248
36PHKG21.34815046
37PHKG11.34815046
38PBK1.31614003
39TIE11.31482318
40LIMK11.30476354
41YES11.29508445
42TBK11.28948273
43LMTK21.25692999
44ADRBK21.25165729
45MAP2K61.23649852
46IRAK21.23091489
47BMPR1B1.22779918
48SGK21.19929444
49LATS11.18849746
50SIK31.15659021
51JAK31.15601765
52PAK41.15585961
53NME21.15027673
54EIF2AK11.09171490
55MAP3K41.07837057
56KIT1.07809154
57SRPK11.05834007
58PDK21.04407729
59FRK1.02059673
60MAPK71.01772476
61MAPKAPK51.01465072
62TGFBR11.01208189
63FGFR21.01107901
64BLK1.01051253
65MAP3K31.00871454
66STK30.97723939
67BCR0.95109419
68OXSR10.93764917
69LRRK20.93193330
70MUSK0.92010735
71TNK20.91644542
72STK100.89507391
73NME10.89075446
74DMPK0.88402803
75PRKCI0.85916357
76CLK10.83199943
77RPS6KB20.82395344
78STK380.81743467
79BTK0.80850617
80INSRR0.78241516
81MAP2K30.77052589
82PTK20.74497392
83PINK10.73430036
84MAP2K70.73376926
85TAOK10.73010245
86BRSK20.71930024
87LATS20.71243659
88ABL20.69798389
89TYK20.69302819
90PIK3CA0.69231849
91MAPK150.68306634
92CDK30.67429730
93CDK80.66896835
94CSNK1A1L0.65915552
95EIF2AK30.65745249
96MATK0.65623432
97ZAP700.64487575
98TAOK20.63465555
99TNIK0.62843791
100NLK0.61591413
101PLK40.61323612
102STK40.60676184
103SYK0.59759422
104CCNB10.59540933
105DAPK10.58618496
106AKT30.58395025
107JAK10.57899753
108DAPK20.57634066
109WNK40.55928620
110ERBB40.55807402
111LYN0.55252555
112MAPKAPK30.54947665
113CDK60.54943187
114FLT30.54682491
115EPHB20.51275401
116TAOK30.50934912
117PRKCE0.50806007
118MYLK0.50415706
119PIM10.50354265
120ACVR1B0.48764725
121CAMK2G0.48639455
122VRK10.48231837
123ILK0.48126056
124TRIM280.47836287
125MAPKAPK20.47559735
126PRKCD0.47364613
127ITK0.47258494
128SGK30.47236670
129HIPK20.47084635
130SIK10.45910402
131FGFR30.45565460
132SGK2230.45493026
133SGK4940.45493026
134PTK60.44696956
135MAP4K10.44575601
136IRAK10.44301741
137PRKG20.43746063
138FER0.43278364
139TGFBR20.42382711
140ADRBK10.42005457
141ROCK10.41962110
142LCK0.41469781
143GSK3A0.40901703
144PRKD20.40182156
145RPS6KC10.40072586
146ARAF0.38081813
147ROCK20.35600176
148PRKAA20.35220005
149FGFR10.33703037
150CSNK1G10.32366640
151CSNK1G30.32063647
152BMX0.31681008
153ABL10.30041996
154EPHB10.26642536
155EGFR0.25392639
156IGF1R0.25305763
157PTK2B0.24344602
158CAMK2D0.23821650
159CSNK1G20.22793738

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.45164596
2Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.05619698
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.65972471
4Arachidonic acid metabolism_Homo sapiens_hsa005902.29028336
5Allograft rejection_Homo sapiens_hsa053302.28940947
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.24296591
7Graft-versus-host disease_Homo sapiens_hsa053322.21121405
8Fatty acid elongation_Homo sapiens_hsa000622.17679102
9Sphingolipid metabolism_Homo sapiens_hsa006002.16831728
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.11430638
11Circadian rhythm_Homo sapiens_hsa047102.06867767
12Retinol metabolism_Homo sapiens_hsa008302.03302334
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.98006270
14Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.89744295
15Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.89248858
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.89172705
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.86282161
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.83633484
19Measles_Homo sapiens_hsa051621.68531005
20NOD-like receptor signaling pathway_Homo sapiens_hsa046211.68475156
21Autoimmune thyroid disease_Homo sapiens_hsa053201.66454746
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.64647314
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.64188369
24Caffeine metabolism_Homo sapiens_hsa002321.62413881
25Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.62360629
26Phototransduction_Homo sapiens_hsa047441.61636823
27SNARE interactions in vesicular transport_Homo sapiens_hsa041301.59440918
28Hematopoietic cell lineage_Homo sapiens_hsa046401.57992151
29Primary immunodeficiency_Homo sapiens_hsa053401.55410183
30Leishmaniasis_Homo sapiens_hsa051401.52926691
31Toll-like receptor signaling pathway_Homo sapiens_hsa046201.51413227
32Chemical carcinogenesis_Homo sapiens_hsa052041.48980768
33Histidine metabolism_Homo sapiens_hsa003401.47682237
34Staphylococcus aureus infection_Homo sapiens_hsa051501.47383146
35Sulfur metabolism_Homo sapiens_hsa009201.45312902
36Pentose and glucuronate interconversions_Homo sapiens_hsa000401.42754599
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.36777436
38Tight junction_Homo sapiens_hsa045301.33885572
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.29830566
40Glutathione metabolism_Homo sapiens_hsa004801.29727013
41ABC transporters_Homo sapiens_hsa020101.29091940
42Rheumatoid arthritis_Homo sapiens_hsa053231.27217693
43Legionellosis_Homo sapiens_hsa051341.26570162
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.26166907
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.24542412
46Peroxisome_Homo sapiens_hsa041461.23794457
47Malaria_Homo sapiens_hsa051441.23446717
48Jak-STAT signaling pathway_Homo sapiens_hsa046301.20556184
49Pertussis_Homo sapiens_hsa051331.20298543
50Herpes simplex infection_Homo sapiens_hsa051681.20208520
51Steroid hormone biosynthesis_Homo sapiens_hsa001401.16115829
52Other glycan degradation_Homo sapiens_hsa005111.15343759
53Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.14114690
54Linoleic acid metabolism_Homo sapiens_hsa005911.10680389
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.10437948
56Base excision repair_Homo sapiens_hsa034101.07547811
57beta-Alanine metabolism_Homo sapiens_hsa004101.07212519
58Collecting duct acid secretion_Homo sapiens_hsa049661.06801392
59Primary bile acid biosynthesis_Homo sapiens_hsa001201.05059614
60Ether lipid metabolism_Homo sapiens_hsa005651.04625411
61Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.03479666
62Asthma_Homo sapiens_hsa053101.03108064
63Huntingtons disease_Homo sapiens_hsa050161.02740904
64Hepatitis C_Homo sapiens_hsa051601.01421365
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.01245809
66Ribosome_Homo sapiens_hsa030101.00480419
67Influenza A_Homo sapiens_hsa051641.00091798
68Vitamin digestion and absorption_Homo sapiens_hsa049771.00055680
69Homologous recombination_Homo sapiens_hsa034400.99738736
70Mineral absorption_Homo sapiens_hsa049780.99304697
71One carbon pool by folate_Homo sapiens_hsa006700.98905896
72Nitrogen metabolism_Homo sapiens_hsa009100.97057603
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96543006
74Cyanoamino acid metabolism_Homo sapiens_hsa004600.95040556
75TNF signaling pathway_Homo sapiens_hsa046680.93195952
76Adherens junction_Homo sapiens_hsa045200.87082654
77Steroid biosynthesis_Homo sapiens_hsa001000.82856179
78Renin-angiotensin system_Homo sapiens_hsa046140.81208313
79Type I diabetes mellitus_Homo sapiens_hsa049400.81080316
80p53 signaling pathway_Homo sapiens_hsa041150.80586549
81Regulation of autophagy_Homo sapiens_hsa041400.80252789
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78350716
83African trypanosomiasis_Homo sapiens_hsa051430.77969548
84Vibrio cholerae infection_Homo sapiens_hsa051100.74376873
85Basal transcription factors_Homo sapiens_hsa030220.74268589
86Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.74140088
87Protein export_Homo sapiens_hsa030600.73964938
88Folate biosynthesis_Homo sapiens_hsa007900.73651348
89Tryptophan metabolism_Homo sapiens_hsa003800.73469667
90Pyrimidine metabolism_Homo sapiens_hsa002400.73305716
91Phenylalanine metabolism_Homo sapiens_hsa003600.72522246
92Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72471224
93Salivary secretion_Homo sapiens_hsa049700.70351443
94Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70005181
95Fatty acid degradation_Homo sapiens_hsa000710.69826473
96Pancreatic secretion_Homo sapiens_hsa049720.69274948
97Fanconi anemia pathway_Homo sapiens_hsa034600.68330096
98Toxoplasmosis_Homo sapiens_hsa051450.67589102
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66190874
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64185277
101Thyroid cancer_Homo sapiens_hsa052160.62826587
102Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.62767205
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.61398483
104Nucleotide excision repair_Homo sapiens_hsa034200.61208109
105Leukocyte transendothelial migration_Homo sapiens_hsa046700.60163512
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59909720
107Amoebiasis_Homo sapiens_hsa051460.59349653
108Tuberculosis_Homo sapiens_hsa051520.59298973
109Renin secretion_Homo sapiens_hsa049240.58617983
110Metabolic pathways_Homo sapiens_hsa011000.57223744
111Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.57213435
112Apoptosis_Homo sapiens_hsa042100.55572568
113Osteoclast differentiation_Homo sapiens_hsa043800.52743283
114Complement and coagulation cascades_Homo sapiens_hsa046100.52550383
115Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52301211
116Glycerolipid metabolism_Homo sapiens_hsa005610.51889793
117Fructose and mannose metabolism_Homo sapiens_hsa000510.51668942
118DNA replication_Homo sapiens_hsa030300.51380942
119Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51157677
120Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49652357
121Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49114579
122Tyrosine metabolism_Homo sapiens_hsa003500.48798178
123Insulin secretion_Homo sapiens_hsa049110.48759568
124RNA degradation_Homo sapiens_hsa030180.48409702
125Insulin resistance_Homo sapiens_hsa049310.47735315
126Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.47659863
127ECM-receptor interaction_Homo sapiens_hsa045120.47167510
128Ovarian steroidogenesis_Homo sapiens_hsa049130.47163098
129Hippo signaling pathway_Homo sapiens_hsa043900.44957468
130Mismatch repair_Homo sapiens_hsa034300.44467038
131Salmonella infection_Homo sapiens_hsa051320.44333025
132PPAR signaling pathway_Homo sapiens_hsa033200.44266967
133Pentose phosphate pathway_Homo sapiens_hsa000300.44257790
134Non-homologous end-joining_Homo sapiens_hsa034500.44070453
135Starch and sucrose metabolism_Homo sapiens_hsa005000.43183900
136Phagosome_Homo sapiens_hsa041450.43044710
137RNA polymerase_Homo sapiens_hsa030200.42531877
138Drug metabolism - other enzymes_Homo sapiens_hsa009830.41470992
139Arginine and proline metabolism_Homo sapiens_hsa003300.38163142
140Dorso-ventral axis formation_Homo sapiens_hsa043200.37762422
141Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.36208599
142Proteoglycans in cancer_Homo sapiens_hsa052050.35090008
143Galactose metabolism_Homo sapiens_hsa000520.34498850
144Lysosome_Homo sapiens_hsa041420.34241823
145TGF-beta signaling pathway_Homo sapiens_hsa043500.33081175
146Bile secretion_Homo sapiens_hsa049760.31454186
147Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.30796637
148Arginine biosynthesis_Homo sapiens_hsa002200.28236811
149Oxidative phosphorylation_Homo sapiens_hsa001900.27416112
150Hedgehog signaling pathway_Homo sapiens_hsa043400.27202226

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