

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | proteasome assembly (GO:0043248) | 5.46203185 |
| 2 | respiratory chain complex IV assembly (GO:0008535) | 4.33992988 |
| 3 | establishment of integrated proviral latency (GO:0075713) | 4.25558559 |
| 4 | cullin deneddylation (GO:0010388) | 4.04898320 |
| 5 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.01217131 |
| 6 | protein deneddylation (GO:0000338) | 4.00494969 |
| 7 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.87658905 |
| 8 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.86779529 |
| 9 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.74299160 |
| 10 | establishment of viral latency (GO:0019043) | 3.66390548 |
| 11 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.65232067 |
| 12 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.63194533 |
| 13 | negative regulation of ligase activity (GO:0051352) | 3.63194533 |
| 14 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.62560457 |
| 15 | DNA double-strand break processing (GO:0000729) | 3.60899165 |
| 16 | cytochrome complex assembly (GO:0017004) | 3.55485426 |
| 17 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.52641522 |
| 18 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.52641522 |
| 19 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.50466275 |
| 20 | purine nucleobase biosynthetic process (GO:0009113) | 3.50178619 |
| 21 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.47001314 |
| 22 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.47001314 |
| 23 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.47001314 |
| 24 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.44765869 |
| 25 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.44765869 |
| 26 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.43433062 |
| 27 | ribosome assembly (GO:0042255) | 3.42470339 |
| 28 | DNA damage response, detection of DNA damage (GO:0042769) | 3.36912929 |
| 29 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.35557269 |
| 30 | protein complex biogenesis (GO:0070271) | 3.33541253 |
| 31 | positive regulation of ligase activity (GO:0051351) | 3.32450153 |
| 32 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.32296740 |
| 33 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.32296740 |
| 34 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.31897517 |
| 35 | regulation of glucokinase activity (GO:0033131) | 3.27939125 |
| 36 | regulation of hexokinase activity (GO:1903299) | 3.27939125 |
| 37 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.26695676 |
| 38 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 3.25907774 |
| 39 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 3.25907774 |
| 40 | CENP-A containing nucleosome assembly (GO:0034080) | 3.21909384 |
| 41 | pseudouridine synthesis (GO:0001522) | 3.21313662 |
| 42 | termination of RNA polymerase III transcription (GO:0006386) | 3.17338456 |
| 43 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.17338456 |
| 44 | tRNA aminoacylation for protein translation (GO:0006418) | 3.16828034 |
| 45 | amino acid activation (GO:0043038) | 3.16568965 |
| 46 | tRNA aminoacylation (GO:0043039) | 3.16568965 |
| 47 | regulation of mitochondrial translation (GO:0070129) | 3.15870864 |
| 48 | peptidyl-histidine modification (GO:0018202) | 3.15512193 |
| 49 | maturation of 5.8S rRNA (GO:0000460) | 3.15418635 |
| 50 | lactate metabolic process (GO:0006089) | 3.13095800 |
| 51 | branched-chain amino acid catabolic process (GO:0009083) | 3.13073673 |
| 52 | oxidative phosphorylation (GO:0006119) | 3.12141778 |
| 53 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.11083653 |
| 54 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.11083653 |
| 55 | NADH dehydrogenase complex assembly (GO:0010257) | 3.11083653 |
| 56 | protein targeting to mitochondrion (GO:0006626) | 3.10893539 |
| 57 | chromatin remodeling at centromere (GO:0031055) | 3.08648246 |
| 58 | DNA deamination (GO:0045006) | 3.06662112 |
| 59 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.05751447 |
| 60 | ribonucleoprotein complex disassembly (GO:0032988) | 3.05694095 |
| 61 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.04910057 |
| 62 | protein-cofactor linkage (GO:0018065) | 3.04481791 |
| 63 | regulation of meiosis I (GO:0060631) | 2.99480436 |
| 64 | protein K6-linked ubiquitination (GO:0085020) | 2.97558704 |
| 65 | regulation of ligase activity (GO:0051340) | 2.97369592 |
| 66 | regulation of helicase activity (GO:0051095) | 2.96119516 |
| 67 | organelle disassembly (GO:1903008) | 2.95561115 |
| 68 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 2.95019101 |
| 69 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 2.93539662 |
| 70 | double-strand break repair via nonhomologous end joining (GO:0006303) | 2.92792246 |
| 71 | non-recombinational repair (GO:0000726) | 2.92792246 |
| 72 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 2.92451738 |
| 73 | nucleobase biosynthetic process (GO:0046112) | 2.91815537 |
| 74 | GMP metabolic process (GO:0046037) | 2.91423300 |
| 75 | ubiquinone biosynthetic process (GO:0006744) | 2.90697732 |
| 76 | de novo protein folding (GO:0006458) | 2.90692718 |
| 77 | mitochondrial RNA metabolic process (GO:0000959) | 2.90574087 |
| 78 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 2.89845749 |
| 79 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 2.89845749 |
| 80 | isotype switching (GO:0045190) | 2.89845749 |
| 81 | protein localization to mitochondrion (GO:0070585) | 2.87609081 |
| 82 | establishment of protein localization to mitochondrion (GO:0072655) | 2.87047710 |
| 83 | pteridine-containing compound biosynthetic process (GO:0042559) | 2.85803026 |
| 84 | tRNA metabolic process (GO:0006399) | 2.82899022 |
| 85 | DNA ligation (GO:0006266) | 2.80058563 |
| 86 | de novo posttranslational protein folding (GO:0051084) | 2.79201437 |
| 87 | iron-sulfur cluster assembly (GO:0016226) | 2.78811479 |
| 88 | metallo-sulfur cluster assembly (GO:0031163) | 2.78811479 |
| 89 | chaperone-mediated protein transport (GO:0072321) | 2.78008964 |
| 90 | ubiquinone metabolic process (GO:0006743) | 2.76850468 |
| 91 | histone H2A acetylation (GO:0043968) | 2.76575831 |
| 92 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 2.75280010 |
| 93 | negative regulation of protein ubiquitination (GO:0031397) | 2.74746085 |
| 94 | ATP synthesis coupled proton transport (GO:0015986) | 2.73195953 |
| 95 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 2.73195953 |
| 96 | 7-methylguanosine mRNA capping (GO:0006370) | 2.71972456 |
| 97 | regulation of mitotic spindle checkpoint (GO:1903504) | 2.71688442 |
| 98 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 2.71688442 |
| 99 | inner mitochondrial membrane organization (GO:0007007) | 2.70849319 |
| 100 | folic acid-containing compound biosynthetic process (GO:0009396) | 2.70579798 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.36175659 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.20929904 |
| 3 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 4.17265457 |
| 4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.78163817 |
| 5 | E2F7_22180533_ChIP-Seq_HELA_Human | 3.57744233 |
| 6 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.42975792 |
| 7 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 3.07909719 |
| 8 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.05588275 |
| 9 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.05130302 |
| 10 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.88423458 |
| 11 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.76662139 |
| 12 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.75733882 |
| 13 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.74513386 |
| 14 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.70593185 |
| 15 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.68859724 |
| 16 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.68675101 |
| 17 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.63363042 |
| 18 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.40245159 |
| 19 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.34580521 |
| 20 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.31165438 |
| 21 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 2.25075886 |
| 22 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.23383500 |
| 23 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.20511645 |
| 24 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.17519084 |
| 25 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 2.12191675 |
| 26 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.09671394 |
| 27 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.09656564 |
| 28 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.09488101 |
| 29 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.05607310 |
| 30 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.00804160 |
| 31 | GABP_19822575_ChIP-Seq_HepG2_Human | 2.00018151 |
| 32 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.98521670 |
| 33 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.96301463 |
| 34 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.95195331 |
| 35 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.94284666 |
| 36 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.92540566 |
| 37 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.69913688 |
| 38 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.68422336 |
| 39 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.67953508 |
| 40 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.67459967 |
| 41 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.61577444 |
| 42 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.58202062 |
| 43 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.47664611 |
| 44 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.46577665 |
| 45 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.44040529 |
| 46 | EWS_26573619_Chip-Seq_HEK293_Human | 1.42307822 |
| 47 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.39988709 |
| 48 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.39406220 |
| 49 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.36884622 |
| 50 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.35957952 |
| 51 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.34735631 |
| 52 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.34568988 |
| 53 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.34544580 |
| 54 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.30242661 |
| 55 | FUS_26573619_Chip-Seq_HEK293_Human | 1.29918257 |
| 56 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.29560795 |
| 57 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.29214645 |
| 58 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.28955569 |
| 59 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.22640641 |
| 60 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.22305029 |
| 61 | VDR_22108803_ChIP-Seq_LS180_Human | 1.21776723 |
| 62 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.19886891 |
| 63 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.17897787 |
| 64 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.13507435 |
| 65 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.13422787 |
| 66 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.13394215 |
| 67 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.12019946 |
| 68 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.11564740 |
| 69 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.11315291 |
| 70 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.10436537 |
| 71 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.09845709 |
| 72 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.07009123 |
| 73 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.06611843 |
| 74 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.06515161 |
| 75 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.06002673 |
| 76 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.00799923 |
| 77 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.00172218 |
| 78 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.99855380 |
| 79 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.95075083 |
| 80 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.95010030 |
| 81 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.94487521 |
| 82 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 0.92681357 |
| 83 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.88836335 |
| 84 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 0.88527565 |
| 85 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.88113741 |
| 86 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.87864032 |
| 87 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.83661761 |
| 88 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.83170762 |
| 89 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.81284274 |
| 90 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.79803135 |
| 91 | P300_19829295_ChIP-Seq_ESCs_Human | 0.78850907 |
| 92 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.77592765 |
| 93 | AR_20517297_ChIP-Seq_VCAP_Human | 0.77475134 |
| 94 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.76416034 |
| 95 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.76211067 |
| 96 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.75557062 |
| 97 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.74946541 |
| 98 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.74448773 |
| 99 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.73601549 |
| 100 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.73587844 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008058_abnormal_DNA_repair | 3.81561930 |
| 2 | MP0003693_abnormal_embryo_hatching | 3.44670338 |
| 3 | MP0004147_increased_porphyrin_level | 3.38092375 |
| 4 | MP0003806_abnormal_nucleotide_metabolis | 3.25663313 |
| 5 | MP0009697_abnormal_copulation | 3.25262461 |
| 6 | MP0010094_abnormal_chromosome_stability | 3.22354090 |
| 7 | MP0008877_abnormal_DNA_methylation | 3.17194510 |
| 8 | MP0001529_abnormal_vocalization | 3.12556883 |
| 9 | MP0006036_abnormal_mitochondrial_physio | 2.78260259 |
| 10 | MP0003718_maternal_effect | 2.74486534 |
| 11 | MP0006072_abnormal_retinal_apoptosis | 2.74204841 |
| 12 | MP0006035_abnormal_mitochondrial_morpho | 2.62657265 |
| 13 | MP0004957_abnormal_blastocyst_morpholog | 2.60957438 |
| 14 | MP0003111_abnormal_nucleus_morphology | 2.37402740 |
| 15 | MP0003786_premature_aging | 2.36241764 |
| 16 | MP0003186_abnormal_redox_activity | 2.33396674 |
| 17 | MP0002102_abnormal_ear_morphology | 2.24578787 |
| 18 | MP0002254_reproductive_system_inflammat | 2.21862873 |
| 19 | MP0008932_abnormal_embryonic_tissue | 2.06744260 |
| 20 | MP0002837_dystrophic_cardiac_calcinosis | 1.96037938 |
| 21 | MP0001764_abnormal_homeostasis | 1.90397373 |
| 22 | MP0008007_abnormal_cellular_replicative | 1.90171010 |
| 23 | MP0000516_abnormal_urinary_system | 1.89665417 |
| 24 | MP0005367_renal/urinary_system_phenotyp | 1.89665417 |
| 25 | MP0003077_abnormal_cell_cycle | 1.86718549 |
| 26 | MP0005379_endocrine/exocrine_gland_phen | 1.81353011 |
| 27 | MP0008789_abnormal_olfactory_epithelium | 1.76396488 |
| 28 | MP0005645_abnormal_hypothalamus_physiol | 1.67140174 |
| 29 | MP0000358_abnormal_cell_content/ | 1.63010381 |
| 30 | MP0003121_genomic_imprinting | 1.54860286 |
| 31 | MP0000647_abnormal_sebaceous_gland | 1.52937430 |
| 32 | MP0005084_abnormal_gallbladder_morpholo | 1.52852017 |
| 33 | MP0005253_abnormal_eye_physiology | 1.51451341 |
| 34 | MP0008995_early_reproductive_senescence | 1.50706166 |
| 35 | MP0002163_abnormal_gland_morphology | 1.49668595 |
| 36 | MP0003011_delayed_dark_adaptation | 1.48495422 |
| 37 | MP0002751_abnormal_autonomic_nervous | 1.48284318 |
| 38 | MP0002822_catalepsy | 1.44453475 |
| 39 | MP0001661_extended_life_span | 1.44009655 |
| 40 | MP0002090_abnormal_vision | 1.43556093 |
| 41 | MP0003787_abnormal_imprinting | 1.40782345 |
| 42 | MP0005075_abnormal_melanosome_morpholog | 1.33161175 |
| 43 | MP0001727_abnormal_embryo_implantation | 1.26351772 |
| 44 | MP0003195_calcinosis | 1.25956246 |
| 45 | MP0003122_maternal_imprinting | 1.22691633 |
| 46 | MP0008057_abnormal_DNA_replication | 1.18578098 |
| 47 | MP0001929_abnormal_gametogenesis | 1.18002449 |
| 48 | MP0006054_spinal_hemorrhage | 1.14771913 |
| 49 | MP0000372_irregular_coat_pigmentation | 1.11973228 |
| 50 | MP0001730_embryonic_growth_arrest | 1.11716788 |
| 51 | MP0005499_abnormal_olfactory_system | 1.11313924 |
| 52 | MP0005394_taste/olfaction_phenotype | 1.11313924 |
| 53 | MP0002210_abnormal_sex_determination | 1.10445213 |
| 54 | MP0002234_abnormal_pharynx_morphology | 1.09735384 |
| 55 | MP0005551_abnormal_eye_electrophysiolog | 1.08443657 |
| 56 | MP0000653_abnormal_sex_gland | 1.01079222 |
| 57 | MP0005332_abnormal_amino_acid | 0.98819311 |
| 58 | MP0000383_abnormal_hair_follicle | 0.97651852 |
| 59 | MP0002736_abnormal_nociception_after | 0.95898195 |
| 60 | MP0001145_abnormal_male_reproductive | 0.93386597 |
| 61 | MP0005636_abnormal_mineral_homeostasis | 0.91395474 |
| 62 | MP0006292_abnormal_olfactory_placode | 0.90227373 |
| 63 | MP0000427_abnormal_hair_cycle | 0.90037249 |
| 64 | MP0001697_abnormal_embryo_size | 0.88138268 |
| 65 | MP0010678_abnormal_skin_adnexa | 0.88017739 |
| 66 | MP0010352_gastrointestinal_tract_polyps | 0.86679021 |
| 67 | MP0005395_other_phenotype | 0.86486912 |
| 68 | MP0008875_abnormal_xenobiotic_pharmacok | 0.86485490 |
| 69 | MP0005220_abnormal_exocrine_pancreas | 0.86483736 |
| 70 | MP0001119_abnormal_female_reproductive | 0.86232445 |
| 71 | MP0000313_abnormal_cell_death | 0.84488159 |
| 72 | MP0005410_abnormal_fertilization | 0.84017974 |
| 73 | MP0002139_abnormal_hepatobiliary_system | 0.79406333 |
| 74 | MP0004233_abnormal_muscle_weight | 0.77364173 |
| 75 | MP0003890_abnormal_embryonic-extraembry | 0.76980958 |
| 76 | MP0003567_abnormal_fetal_cardiomyocyte | 0.76776881 |
| 77 | MP0003656_abnormal_erythrocyte_physiolo | 0.76564761 |
| 78 | MP0002080_prenatal_lethality | 0.75119760 |
| 79 | MP0005266_abnormal_metabolism | 0.74942099 |
| 80 | MP0002084_abnormal_developmental_patter | 0.74235138 |
| 81 | MP0003880_abnormal_central_pattern | 0.72303397 |
| 82 | MP0002233_abnormal_nose_morphology | 0.69495833 |
| 83 | MP0004215_abnormal_myocardial_fiber | 0.69203067 |
| 84 | MP0002693_abnormal_pancreas_physiology | 0.69000583 |
| 85 | MP0001919_abnormal_reproductive_system | 0.68950877 |
| 86 | MP0001984_abnormal_olfaction | 0.68664750 |
| 87 | MP0005389_reproductive_system_phenotype | 0.67785414 |
| 88 | MP0003698_abnormal_male_reproductive | 0.67148503 |
| 89 | MP0002006_tumorigenesis | 0.66973686 |
| 90 | MP0005380_embryogenesis_phenotype | 0.66953422 |
| 91 | MP0001672_abnormal_embryogenesis/_devel | 0.66953422 |
| 92 | MP0004133_heterotaxia | 0.66787650 |
| 93 | MP0010386_abnormal_urinary_bladder | 0.66186041 |
| 94 | MP0005647_abnormal_sex_gland | 0.65598658 |
| 95 | MP0000350_abnormal_cell_proliferation | 0.65042547 |
| 96 | MP0009046_muscle_twitch | 0.63793295 |
| 97 | MP0005319_abnormal_enzyme/_coenzyme | 0.62654719 |
| 98 | MP0006276_abnormal_autonomic_nervous | 0.61504183 |
| 99 | MP0008872_abnormal_physiological_respon | 0.60914332 |
| 100 | MP0005187_abnormal_penis_morphology | 0.58600917 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 4.69955765 |
| 2 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.35740702 |
| 3 | Acute encephalopathy (HP:0006846) | 4.17235581 |
| 4 | Progressive macrocephaly (HP:0004481) | 4.12385095 |
| 5 | Increased CSF lactate (HP:0002490) | 4.07231201 |
| 6 | Hepatocellular necrosis (HP:0001404) | 4.06630108 |
| 7 | Mitochondrial inheritance (HP:0001427) | 4.02793953 |
| 8 | Hepatic necrosis (HP:0002605) | 3.83701280 |
| 9 | Cerebral edema (HP:0002181) | 3.47076438 |
| 10 | 3-Methylglutaconic aciduria (HP:0003535) | 3.34714341 |
| 11 | Increased hepatocellular lipid droplets (HP:0006565) | 3.31354861 |
| 12 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.29547024 |
| 13 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.29547024 |
| 14 | Lipid accumulation in hepatocytes (HP:0006561) | 3.24938191 |
| 15 | Increased serum lactate (HP:0002151) | 3.20660743 |
| 16 | Type I transferrin isoform profile (HP:0003642) | 3.08356163 |
| 17 | Lactic acidosis (HP:0003128) | 3.00469542 |
| 18 | Intestinal atresia (HP:0011100) | 2.91467916 |
| 19 | Pancreatic islet-cell hyperplasia (HP:0004510) | 2.90919792 |
| 20 | Microvesicular hepatic steatosis (HP:0001414) | 2.89375944 |
| 21 | Respiratory failure (HP:0002878) | 2.86435566 |
| 22 | Increased serum pyruvate (HP:0003542) | 2.71541282 |
| 23 | Abnormality of the pancreatic islet cells (HP:0006476) | 2.69334091 |
| 24 | Abnormality of endocrine pancreas physiology (HP:0012093) | 2.69334091 |
| 25 | Reduced antithrombin III activity (HP:0001976) | 2.68744053 |
| 26 | Abnormal protein glycosylation (HP:0012346) | 2.59696100 |
| 27 | Abnormal glycosylation (HP:0012345) | 2.59696100 |
| 28 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.59696100 |
| 29 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.59696100 |
| 30 | Abnormality of the labia minora (HP:0012880) | 2.54974829 |
| 31 | Renal Fanconi syndrome (HP:0001994) | 2.54613102 |
| 32 | Hyperinsulinemic hypoglycemia (HP:0000825) | 2.52247978 |
| 33 | Colon cancer (HP:0003003) | 2.52201629 |
| 34 | Abnormality of glycolysis (HP:0004366) | 2.51441331 |
| 35 | Methylmalonic acidemia (HP:0002912) | 2.46839095 |
| 36 | Abnormality of the anterior horn cell (HP:0006802) | 2.46777622 |
| 37 | Degeneration of anterior horn cells (HP:0002398) | 2.46777622 |
| 38 | Exercise intolerance (HP:0003546) | 2.40978614 |
| 39 | CNS demyelination (HP:0007305) | 2.38642645 |
| 40 | Aplastic anemia (HP:0001915) | 2.37844694 |
| 41 | Abnormality of methionine metabolism (HP:0010901) | 2.35768468 |
| 42 | Ketoacidosis (HP:0001993) | 2.33791571 |
| 43 | Medial flaring of the eyebrow (HP:0010747) | 2.29600593 |
| 44 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.25388976 |
| 45 | Lethargy (HP:0001254) | 2.25290076 |
| 46 | Hypoglycemic coma (HP:0001325) | 2.24417365 |
| 47 | Neoplasm of the adrenal gland (HP:0100631) | 2.23140826 |
| 48 | Hypothermia (HP:0002045) | 2.22490929 |
| 49 | Increased intramyocellular lipid droplets (HP:0012240) | 2.20502455 |
| 50 | Methylmalonic aciduria (HP:0012120) | 2.13949097 |
| 51 | Ependymoma (HP:0002888) | 2.12803167 |
| 52 | Hypoglycemic seizures (HP:0002173) | 2.12730457 |
| 53 | Hyperglycinemia (HP:0002154) | 2.12661541 |
| 54 | Agnosia (HP:0010524) | 2.10822173 |
| 55 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.07671933 |
| 56 | Leukodystrophy (HP:0002415) | 2.07632509 |
| 57 | Optic disc pallor (HP:0000543) | 2.06513488 |
| 58 | Symptomatic seizures (HP:0011145) | 2.05326908 |
| 59 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.04996428 |
| 60 | Medulloblastoma (HP:0002885) | 2.04202596 |
| 61 | Hyperglycemia (HP:0003074) | 1.98288204 |
| 62 | Abnormality of serum amino acid levels (HP:0003112) | 1.96643469 |
| 63 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 1.96472718 |
| 64 | Short tibia (HP:0005736) | 1.92691655 |
| 65 | Congenital primary aphakia (HP:0007707) | 1.91466292 |
| 66 | Abnormality of alanine metabolism (HP:0010916) | 1.91289133 |
| 67 | Hyperalaninemia (HP:0003348) | 1.91289133 |
| 68 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.91289133 |
| 69 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.90860242 |
| 70 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.89892016 |
| 71 | Abnormality of glycine metabolism (HP:0010895) | 1.89892016 |
| 72 | Volvulus (HP:0002580) | 1.88805512 |
| 73 | Prominent metopic ridge (HP:0005487) | 1.88376540 |
| 74 | Emotional lability (HP:0000712) | 1.88349807 |
| 75 | Abnormality of the ileum (HP:0001549) | 1.87319200 |
| 76 | Increased muscle lipid content (HP:0009058) | 1.86431384 |
| 77 | Generalized aminoaciduria (HP:0002909) | 1.84120731 |
| 78 | Nephrogenic diabetes insipidus (HP:0009806) | 1.82855265 |
| 79 | Hyperglycinuria (HP:0003108) | 1.81966838 |
| 80 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 1.80278548 |
| 81 | Exertional dyspnea (HP:0002875) | 1.79086774 |
| 82 | Abnormality of the metopic suture (HP:0005556) | 1.75184914 |
| 83 | Multiple enchondromatosis (HP:0005701) | 1.74972102 |
| 84 | Meckel diverticulum (HP:0002245) | 1.73322354 |
| 85 | Hypoproteinemia (HP:0003075) | 1.71938789 |
| 86 | Abnormality of the preputium (HP:0100587) | 1.71446304 |
| 87 | Abnormality of urine glucose concentration (HP:0011016) | 1.71176840 |
| 88 | Glycosuria (HP:0003076) | 1.71176840 |
| 89 | Shoulder girdle muscle weakness (HP:0003547) | 1.70855522 |
| 90 | Gait imbalance (HP:0002141) | 1.68070242 |
| 91 | Tongue fasciculations (HP:0001308) | 1.67995230 |
| 92 | Abnormal lung lobation (HP:0002101) | 1.66901439 |
| 93 | Median cleft lip (HP:0000161) | 1.66517649 |
| 94 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 1.65576314 |
| 95 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.65337802 |
| 96 | Dicarboxylic aciduria (HP:0003215) | 1.65337802 |
| 97 | Abnormality of the fetal cardiovascular system (HP:0010948) | 1.64948752 |
| 98 | Abnormal umbilical cord blood vessels (HP:0011403) | 1.64948752 |
| 99 | Single umbilical artery (HP:0001195) | 1.64948752 |
| 100 | Posterior subcapsular cataract (HP:0007787) | 1.64895352 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MAP4K2 | 3.36290797 |
| 2 | MST4 | 3.36000827 |
| 3 | EIF2AK3 | 3.09212610 |
| 4 | MAP3K12 | 3.01646043 |
| 5 | BUB1 | 2.99412736 |
| 6 | VRK2 | 2.97382023 |
| 7 | PBK | 2.87086657 |
| 8 | SRPK1 | 2.85747464 |
| 9 | BCKDK | 2.59360406 |
| 10 | NEK1 | 2.52450003 |
| 11 | EIF2AK1 | 2.37940411 |
| 12 | ZAK | 2.34864494 |
| 13 | TRIM28 | 2.22960039 |
| 14 | NME2 | 2.06845714 |
| 15 | CSNK1G3 | 1.96176520 |
| 16 | STK16 | 1.93100825 |
| 17 | WEE1 | 1.85790410 |
| 18 | PLK3 | 1.83952100 |
| 19 | TSSK6 | 1.83917114 |
| 20 | TTK | 1.83182057 |
| 21 | CSNK1G1 | 1.79754757 |
| 22 | ERBB3 | 1.79010982 |
| 23 | VRK1 | 1.76158601 |
| 24 | BCR | 1.71254236 |
| 25 | FRK | 1.63234094 |
| 26 | CSNK1A1L | 1.60945159 |
| 27 | CSNK1G2 | 1.60229126 |
| 28 | WNK3 | 1.56473116 |
| 29 | CCNB1 | 1.43604726 |
| 30 | BRSK2 | 1.30320360 |
| 31 | MKNK1 | 1.28199836 |
| 32 | SCYL2 | 1.27213516 |
| 33 | PLK4 | 1.24643792 |
| 34 | LIMK1 | 1.22442997 |
| 35 | NUAK1 | 1.21175659 |
| 36 | CDC7 | 1.20082533 |
| 37 | PLK1 | 1.15758582 |
| 38 | TESK2 | 1.14603717 |
| 39 | TESK1 | 1.07074038 |
| 40 | PDK2 | 0.98174945 |
| 41 | PAK4 | 0.97866676 |
| 42 | DAPK1 | 0.97465714 |
| 43 | PASK | 0.93766952 |
| 44 | PINK1 | 0.93459369 |
| 45 | MKNK2 | 0.92826184 |
| 46 | MAP3K4 | 0.92333678 |
| 47 | STK38L | 0.90094964 |
| 48 | KDR | 0.89680724 |
| 49 | PLK2 | 0.84549591 |
| 50 | RPS6KA4 | 0.82175359 |
| 51 | BMPR1B | 0.80547195 |
| 52 | MYLK | 0.79515365 |
| 53 | ADRBK2 | 0.78766356 |
| 54 | EIF2AK2 | 0.76660800 |
| 55 | ATR | 0.76004124 |
| 56 | AURKB | 0.75800775 |
| 57 | GRK1 | 0.74819028 |
| 58 | ACVR1B | 0.72875764 |
| 59 | MAP2K7 | 0.68015924 |
| 60 | TAF1 | 0.67796084 |
| 61 | BRSK1 | 0.67113719 |
| 62 | TLK1 | 0.59653188 |
| 63 | MAPK13 | 0.59642684 |
| 64 | DYRK2 | 0.58989309 |
| 65 | FER | 0.58916393 |
| 66 | ATM | 0.58803521 |
| 67 | PHKG1 | 0.58778063 |
| 68 | PHKG2 | 0.58778063 |
| 69 | AURKA | 0.56924660 |
| 70 | CSNK2A1 | 0.56845769 |
| 71 | CLK1 | 0.56670579 |
| 72 | ILK | 0.56466164 |
| 73 | ERBB4 | 0.55876292 |
| 74 | PRKCE | 0.47244187 |
| 75 | CSNK2A2 | 0.45248694 |
| 76 | RPS6KA5 | 0.40859215 |
| 77 | FLT3 | 0.39786203 |
| 78 | CSNK1A1 | 0.39619357 |
| 79 | CHEK2 | 0.38412552 |
| 80 | CHEK1 | 0.37406508 |
| 81 | PRKCI | 0.36647723 |
| 82 | EPHA4 | 0.36068009 |
| 83 | STK3 | 0.35898358 |
| 84 | MATK | 0.34837869 |
| 85 | MAPKAPK5 | 0.31829938 |
| 86 | DAPK3 | 0.31271878 |
| 87 | PRKD3 | 0.30973332 |
| 88 | STK24 | 0.29258960 |
| 89 | PIM2 | 0.29158114 |
| 90 | CDK7 | 0.28700075 |
| 91 | OXSR1 | 0.28579497 |
| 92 | DYRK3 | 0.28177308 |
| 93 | CSNK1D | 0.27890800 |
| 94 | INSRR | 0.27765682 |
| 95 | TIE1 | 0.27466406 |
| 96 | ABL2 | 0.27117371 |
| 97 | TAOK3 | 0.26799498 |
| 98 | MAP3K5 | 0.26449606 |
| 99 | CDK14 | 0.26158769 |
| 100 | TEC | 0.22144589 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.29297497 |
| 2 | Protein export_Homo sapiens_hsa03060 | 3.41022028 |
| 3 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.82392523 |
| 4 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.72821020 |
| 5 | RNA polymerase_Homo sapiens_hsa03020 | 2.66191291 |
| 6 | Mismatch repair_Homo sapiens_hsa03430 | 2.54429393 |
| 7 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.46926570 |
| 8 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.36494529 |
| 9 | DNA replication_Homo sapiens_hsa03030 | 2.30499307 |
| 10 | Parkinsons disease_Homo sapiens_hsa05012 | 2.22299127 |
| 11 | Propanoate metabolism_Homo sapiens_hsa00640 | 2.07286481 |
| 12 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 2.05154388 |
| 13 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 2.05038082 |
| 14 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.95551953 |
| 15 | Basal transcription factors_Homo sapiens_hsa03022 | 1.93729636 |
| 16 | Base excision repair_Homo sapiens_hsa03410 | 1.87977074 |
| 17 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.86104954 |
| 18 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.85610845 |
| 19 | Homologous recombination_Homo sapiens_hsa03440 | 1.83616238 |
| 20 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.83323886 |
| 21 | RNA transport_Homo sapiens_hsa03013 | 1.80512511 |
| 22 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.79416139 |
| 23 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.73938965 |
| 24 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.71081561 |
| 25 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.70874803 |
| 26 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.70345648 |
| 27 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.69654089 |
| 28 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.62544463 |
| 29 | Spliceosome_Homo sapiens_hsa03040 | 1.61500011 |
| 30 | Huntingtons disease_Homo sapiens_hsa05016 | 1.55482318 |
| 31 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.52750904 |
| 32 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.50837605 |
| 33 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.48128891 |
| 34 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.44632444 |
| 35 | RNA degradation_Homo sapiens_hsa03018 | 1.43442283 |
| 36 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.37322813 |
| 37 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.31784112 |
| 38 | Purine metabolism_Homo sapiens_hsa00230 | 1.28296915 |
| 39 | Alzheimers disease_Homo sapiens_hsa05010 | 1.24068108 |
| 40 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.23500274 |
| 41 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.21301758 |
| 42 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.20404206 |
| 43 | Carbon metabolism_Homo sapiens_hsa01200 | 1.19605902 |
| 44 | Cell cycle_Homo sapiens_hsa04110 | 1.09760735 |
| 45 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.03279616 |
| 46 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.01806096 |
| 47 | Peroxisome_Homo sapiens_hsa04146 | 1.00656027 |
| 48 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.00351743 |
| 49 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.99285074 |
| 50 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.98575769 |
| 51 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.97456290 |
| 52 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.91806444 |
| 53 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.91451561 |
| 54 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.91384256 |
| 55 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.88162524 |
| 56 | Metabolic pathways_Homo sapiens_hsa01100 | 0.84608628 |
| 57 | Ribosome_Homo sapiens_hsa03010 | 0.84404681 |
| 58 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.83031768 |
| 59 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.82922337 |
| 60 | Phototransduction_Homo sapiens_hsa04744 | 0.82586719 |
| 61 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.82237201 |
| 62 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.75705998 |
| 63 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.71068281 |
| 64 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.70206571 |
| 65 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.67589339 |
| 66 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.67235895 |
| 67 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.64981845 |
| 68 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.63943277 |
| 69 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.62709146 |
| 70 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.62084021 |
| 71 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.58693816 |
| 72 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.56983370 |
| 73 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.56332277 |
| 74 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.55824863 |
| 75 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.49710202 |
| 76 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.49425362 |
| 77 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.48022754 |
| 78 | Legionellosis_Homo sapiens_hsa05134 | 0.45917411 |
| 79 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.45314739 |
| 80 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.43490387 |
| 81 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.43140789 |
| 82 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.39905735 |
| 83 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.39421494 |
| 84 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.37414771 |
| 85 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.36843612 |
| 86 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.35739852 |
| 87 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.33204420 |
| 88 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.30362830 |
| 89 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.30021856 |
| 90 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.28446000 |
| 91 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.27681381 |
| 92 | Shigellosis_Homo sapiens_hsa05131 | 0.26801154 |
| 93 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.23433047 |
| 94 | Galactose metabolism_Homo sapiens_hsa00052 | 0.23317117 |
| 95 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.20581943 |
| 96 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.20467640 |
| 97 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.20437702 |
| 98 | Lysosome_Homo sapiens_hsa04142 | 0.18668105 |
| 99 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.17216793 |
| 100 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.15712828 |

