BTF3L4P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.46203185
2respiratory chain complex IV assembly (GO:0008535)4.33992988
3establishment of integrated proviral latency (GO:0075713)4.25558559
4cullin deneddylation (GO:0010388)4.04898320
5negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.01217131
6protein deneddylation (GO:0000338)4.00494969
7regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.87658905
8positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.86779529
9regulation of cellular amino acid metabolic process (GO:0006521)3.74299160
10establishment of viral latency (GO:0019043)3.66390548
11anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.65232067
12negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.63194533
13negative regulation of ligase activity (GO:0051352)3.63194533
14establishment of protein localization to mitochondrial membrane (GO:0090151)3.62560457
15DNA double-strand break processing (GO:0000729)3.60899165
16cytochrome complex assembly (GO:0017004)3.55485426
17tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.52641522
18RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.52641522
19DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.50466275
20purine nucleobase biosynthetic process (GO:0009113)3.50178619
21signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.47001314
22signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.47001314
23signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.47001314
24intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.44765869
25signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.44765869
26positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.43433062
27ribosome assembly (GO:0042255)3.42470339
28DNA damage response, detection of DNA damage (GO:0042769)3.36912929
29signal transduction involved in cell cycle checkpoint (GO:0072395)3.35557269
30protein complex biogenesis (GO:0070271)3.33541253
31positive regulation of ligase activity (GO:0051351)3.32450153
32signal transduction involved in DNA integrity checkpoint (GO:0072401)3.32296740
33signal transduction involved in DNA damage checkpoint (GO:0072422)3.32296740
34mitochondrial respiratory chain complex assembly (GO:0033108)3.31897517
35regulation of glucokinase activity (GO:0033131)3.27939125
36regulation of hexokinase activity (GO:1903299)3.27939125
37mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.26695676
38somatic diversification of immune receptors via somatic mutation (GO:0002566)3.25907774
39somatic hypermutation of immunoglobulin genes (GO:0016446)3.25907774
40CENP-A containing nucleosome assembly (GO:0034080)3.21909384
41pseudouridine synthesis (GO:0001522)3.21313662
42termination of RNA polymerase III transcription (GO:0006386)3.17338456
43transcription elongation from RNA polymerase III promoter (GO:0006385)3.17338456
44tRNA aminoacylation for protein translation (GO:0006418)3.16828034
45amino acid activation (GO:0043038)3.16568965
46tRNA aminoacylation (GO:0043039)3.16568965
47regulation of mitochondrial translation (GO:0070129)3.15870864
48peptidyl-histidine modification (GO:0018202)3.15512193
49maturation of 5.8S rRNA (GO:0000460)3.15418635
50lactate metabolic process (GO:0006089)3.13095800
51branched-chain amino acid catabolic process (GO:0009083)3.13073673
52oxidative phosphorylation (GO:0006119)3.12141778
53mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.11083653
54mitochondrial respiratory chain complex I assembly (GO:0032981)3.11083653
55NADH dehydrogenase complex assembly (GO:0010257)3.11083653
56protein targeting to mitochondrion (GO:0006626)3.10893539
57chromatin remodeling at centromere (GO:0031055)3.08648246
58DNA deamination (GO:0045006)3.06662112
59nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.05751447
60ribonucleoprotein complex disassembly (GO:0032988)3.05694095
61regulation of ubiquitin-protein transferase activity (GO:0051438)3.04910057
62protein-cofactor linkage (GO:0018065)3.04481791
63regulation of meiosis I (GO:0060631)2.99480436
64protein K6-linked ubiquitination (GO:0085020)2.97558704
65regulation of ligase activity (GO:0051340)2.97369592
66regulation of helicase activity (GO:0051095)2.96119516
67organelle disassembly (GO:1903008)2.95561115
68mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.95019101
69L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.93539662
70double-strand break repair via nonhomologous end joining (GO:0006303)2.92792246
71non-recombinational repair (GO:0000726)2.92792246
72exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.92451738
73nucleobase biosynthetic process (GO:0046112)2.91815537
74GMP metabolic process (GO:0046037)2.91423300
75ubiquinone biosynthetic process (GO:0006744)2.90697732
76de novo protein folding (GO:0006458)2.90692718
77mitochondrial RNA metabolic process (GO:0000959)2.90574087
78somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.89845749
79somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.89845749
80isotype switching (GO:0045190)2.89845749
81protein localization to mitochondrion (GO:0070585)2.87609081
82establishment of protein localization to mitochondrion (GO:0072655)2.87047710
83pteridine-containing compound biosynthetic process (GO:0042559)2.85803026
84tRNA metabolic process (GO:0006399)2.82899022
85DNA ligation (GO:0006266)2.80058563
86de novo posttranslational protein folding (GO:0051084)2.79201437
87iron-sulfur cluster assembly (GO:0016226)2.78811479
88metallo-sulfur cluster assembly (GO:0031163)2.78811479
89chaperone-mediated protein transport (GO:0072321)2.78008964
90ubiquinone metabolic process (GO:0006743)2.76850468
91histone H2A acetylation (GO:0043968)2.76575831
92deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.75280010
93negative regulation of protein ubiquitination (GO:0031397)2.74746085
94ATP synthesis coupled proton transport (GO:0015986)2.73195953
95energy coupled proton transport, down electrochemical gradient (GO:0015985)2.73195953
967-methylguanosine mRNA capping (GO:0006370)2.71972456
97regulation of mitotic spindle checkpoint (GO:1903504)2.71688442
98regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.71688442
99inner mitochondrial membrane organization (GO:0007007)2.70849319
100folic acid-containing compound biosynthetic process (GO:0009396)2.70579798

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.36175659
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.20929904
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.17265457
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.78163817
5E2F7_22180533_ChIP-Seq_HELA_Human3.57744233
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.42975792
7CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.07909719
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.05588275
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.05130302
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.88423458
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.76662139
12ELK1_19687146_ChIP-ChIP_HELA_Human2.75733882
13VDR_23849224_ChIP-Seq_CD4+_Human2.74513386
14PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.70593185
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.68859724
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.68675101
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.63363042
18DCP1A_22483619_ChIP-Seq_HELA_Human2.40245159
19FOXP3_21729870_ChIP-Seq_TREG_Human2.34580521
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.31165438
21FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.25075886
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.23383500
23MYC_18358816_ChIP-ChIP_MESCs_Mouse2.20511645
24MYC_19030024_ChIP-ChIP_MESCs_Mouse2.17519084
25PADI4_21655091_ChIP-ChIP_MCF-7_Human2.12191675
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.09671394
27ZNF274_21170338_ChIP-Seq_K562_Hela2.09656564
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.09488101
29PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.05607310
30E2F1_18555785_ChIP-Seq_MESCs_Mouse2.00804160
31GABP_19822575_ChIP-Seq_HepG2_Human2.00018151
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.98521670
33HOXB4_20404135_ChIP-ChIP_EML_Mouse1.96301463
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.95195331
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.94284666
36FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.92540566
37ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.69913688
38YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68422336
39TTF2_22483619_ChIP-Seq_HELA_Human1.67953508
40MYCN_18555785_ChIP-Seq_MESCs_Mouse1.67459967
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.61577444
42IGF1R_20145208_ChIP-Seq_DFB_Human1.58202062
43MYC_19079543_ChIP-ChIP_MESCs_Mouse1.47664611
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.46577665
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.44040529
46EWS_26573619_Chip-Seq_HEK293_Human1.42307822
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.39988709
48KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.39406220
49XRN2_22483619_ChIP-Seq_HELA_Human1.36884622
50MYC_18940864_ChIP-ChIP_HL60_Human1.35957952
51PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.34735631
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.34568988
53CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.34544580
54POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.30242661
55FUS_26573619_Chip-Seq_HEK293_Human1.29918257
56ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29560795
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.29214645
58POU3F2_20337985_ChIP-ChIP_501MEL_Human1.28955569
59AR_21909140_ChIP-Seq_LNCAP_Human1.22640641
60HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.22305029
61VDR_22108803_ChIP-Seq_LS180_Human1.21776723
62FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.19886891
63SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.17897787
64ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13507435
65IRF1_19129219_ChIP-ChIP_H3396_Human1.13422787
66TFEB_21752829_ChIP-Seq_HELA_Human1.13394215
67KDM5A_27292631_Chip-Seq_BREAST_Human1.12019946
68PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11564740
69MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.11315291
70ELK1_22589737_ChIP-Seq_MCF10A_Human1.10436537
71E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09845709
72FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.07009123
73E2F1_21310950_ChIP-Seq_MCF-7_Human1.06611843
74ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06515161
75CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.06002673
76CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.00799923
77TP53_22573176_ChIP-Seq_HFKS_Human1.00172218
78BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99855380
79NANOG_16153702_ChIP-ChIP_HESCs_Human0.95075083
80RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.95010030
81ZFP57_27257070_Chip-Seq_ESCs_Mouse0.94487521
82CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.92681357
83CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.88836335
84NANOG_18555785_ChIP-Seq_MESCs_Mouse0.88527565
85SOX2_16153702_ChIP-ChIP_HESCs_Human0.88113741
86HTT_18923047_ChIP-ChIP_STHdh_Human0.87864032
87SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.83661761
88SOX17_20123909_ChIP-Seq_XEN_Mouse0.83170762
89TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81284274
90DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.79803135
91P300_19829295_ChIP-Seq_ESCs_Human0.78850907
92ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.77592765
93AR_20517297_ChIP-Seq_VCAP_Human0.77475134
94TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.76416034
95EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.76211067
96EZH2_27294783_Chip-Seq_NPCs_Mouse0.75557062
97PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.74946541
98CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.74448773
99ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.73601549
100NANOG_19829295_ChIP-Seq_ESCs_Human0.73587844

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair3.81561930
2MP0003693_abnormal_embryo_hatching3.44670338
3MP0004147_increased_porphyrin_level3.38092375
4MP0003806_abnormal_nucleotide_metabolis3.25663313
5MP0009697_abnormal_copulation3.25262461
6MP0010094_abnormal_chromosome_stability3.22354090
7MP0008877_abnormal_DNA_methylation3.17194510
8MP0001529_abnormal_vocalization3.12556883
9MP0006036_abnormal_mitochondrial_physio2.78260259
10MP0003718_maternal_effect2.74486534
11MP0006072_abnormal_retinal_apoptosis2.74204841
12MP0006035_abnormal_mitochondrial_morpho2.62657265
13MP0004957_abnormal_blastocyst_morpholog2.60957438
14MP0003111_abnormal_nucleus_morphology2.37402740
15MP0003786_premature_aging2.36241764
16MP0003186_abnormal_redox_activity2.33396674
17MP0002102_abnormal_ear_morphology2.24578787
18MP0002254_reproductive_system_inflammat2.21862873
19MP0008932_abnormal_embryonic_tissue2.06744260
20MP0002837_dystrophic_cardiac_calcinosis1.96037938
21MP0001764_abnormal_homeostasis1.90397373
22MP0008007_abnormal_cellular_replicative1.90171010
23MP0000516_abnormal_urinary_system1.89665417
24MP0005367_renal/urinary_system_phenotyp1.89665417
25MP0003077_abnormal_cell_cycle1.86718549
26MP0005379_endocrine/exocrine_gland_phen1.81353011
27MP0008789_abnormal_olfactory_epithelium1.76396488
28MP0005645_abnormal_hypothalamus_physiol1.67140174
29MP0000358_abnormal_cell_content/1.63010381
30MP0003121_genomic_imprinting1.54860286
31MP0000647_abnormal_sebaceous_gland1.52937430
32MP0005084_abnormal_gallbladder_morpholo1.52852017
33MP0005253_abnormal_eye_physiology1.51451341
34MP0008995_early_reproductive_senescence1.50706166
35MP0002163_abnormal_gland_morphology1.49668595
36MP0003011_delayed_dark_adaptation1.48495422
37MP0002751_abnormal_autonomic_nervous1.48284318
38MP0002822_catalepsy1.44453475
39MP0001661_extended_life_span1.44009655
40MP0002090_abnormal_vision1.43556093
41MP0003787_abnormal_imprinting1.40782345
42MP0005075_abnormal_melanosome_morpholog1.33161175
43MP0001727_abnormal_embryo_implantation1.26351772
44MP0003195_calcinosis1.25956246
45MP0003122_maternal_imprinting1.22691633
46MP0008057_abnormal_DNA_replication1.18578098
47MP0001929_abnormal_gametogenesis1.18002449
48MP0006054_spinal_hemorrhage1.14771913
49MP0000372_irregular_coat_pigmentation1.11973228
50MP0001730_embryonic_growth_arrest1.11716788
51MP0005499_abnormal_olfactory_system1.11313924
52MP0005394_taste/olfaction_phenotype1.11313924
53MP0002210_abnormal_sex_determination1.10445213
54MP0002234_abnormal_pharynx_morphology1.09735384
55MP0005551_abnormal_eye_electrophysiolog1.08443657
56MP0000653_abnormal_sex_gland1.01079222
57MP0005332_abnormal_amino_acid0.98819311
58MP0000383_abnormal_hair_follicle0.97651852
59MP0002736_abnormal_nociception_after0.95898195
60MP0001145_abnormal_male_reproductive0.93386597
61MP0005636_abnormal_mineral_homeostasis0.91395474
62MP0006292_abnormal_olfactory_placode0.90227373
63MP0000427_abnormal_hair_cycle0.90037249
64MP0001697_abnormal_embryo_size0.88138268
65MP0010678_abnormal_skin_adnexa0.88017739
66MP0010352_gastrointestinal_tract_polyps0.86679021
67MP0005395_other_phenotype0.86486912
68MP0008875_abnormal_xenobiotic_pharmacok0.86485490
69MP0005220_abnormal_exocrine_pancreas0.86483736
70MP0001119_abnormal_female_reproductive0.86232445
71MP0000313_abnormal_cell_death0.84488159
72MP0005410_abnormal_fertilization0.84017974
73MP0002139_abnormal_hepatobiliary_system0.79406333
74MP0004233_abnormal_muscle_weight0.77364173
75MP0003890_abnormal_embryonic-extraembry0.76980958
76MP0003567_abnormal_fetal_cardiomyocyte0.76776881
77MP0003656_abnormal_erythrocyte_physiolo0.76564761
78MP0002080_prenatal_lethality0.75119760
79MP0005266_abnormal_metabolism0.74942099
80MP0002084_abnormal_developmental_patter0.74235138
81MP0003880_abnormal_central_pattern0.72303397
82MP0002233_abnormal_nose_morphology0.69495833
83MP0004215_abnormal_myocardial_fiber0.69203067
84MP0002693_abnormal_pancreas_physiology0.69000583
85MP0001919_abnormal_reproductive_system0.68950877
86MP0001984_abnormal_olfaction0.68664750
87MP0005389_reproductive_system_phenotype0.67785414
88MP0003698_abnormal_male_reproductive0.67148503
89MP0002006_tumorigenesis0.66973686
90MP0005380_embryogenesis_phenotype0.66953422
91MP0001672_abnormal_embryogenesis/_devel0.66953422
92MP0004133_heterotaxia0.66787650
93MP0010386_abnormal_urinary_bladder0.66186041
94MP0005647_abnormal_sex_gland0.65598658
95MP0000350_abnormal_cell_proliferation0.65042547
96MP0009046_muscle_twitch0.63793295
97MP0005319_abnormal_enzyme/_coenzyme0.62654719
98MP0006276_abnormal_autonomic_nervous0.61504183
99MP0008872_abnormal_physiological_respon0.60914332
100MP0005187_abnormal_penis_morphology0.58600917

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.69955765
2Abnormal mitochondria in muscle tissue (HP:0008316)4.35740702
3Acute encephalopathy (HP:0006846)4.17235581
4Progressive macrocephaly (HP:0004481)4.12385095
5Increased CSF lactate (HP:0002490)4.07231201
6Hepatocellular necrosis (HP:0001404)4.06630108
7Mitochondrial inheritance (HP:0001427)4.02793953
8Hepatic necrosis (HP:0002605)3.83701280
9Cerebral edema (HP:0002181)3.47076438
103-Methylglutaconic aciduria (HP:0003535)3.34714341
11Increased hepatocellular lipid droplets (HP:0006565)3.31354861
12Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.29547024
13Decreased activity of mitochondrial respiratory chain (HP:0008972)3.29547024
14Lipid accumulation in hepatocytes (HP:0006561)3.24938191
15Increased serum lactate (HP:0002151)3.20660743
16Type I transferrin isoform profile (HP:0003642)3.08356163
17Lactic acidosis (HP:0003128)3.00469542
18Intestinal atresia (HP:0011100)2.91467916
19Pancreatic islet-cell hyperplasia (HP:0004510)2.90919792
20Microvesicular hepatic steatosis (HP:0001414)2.89375944
21Respiratory failure (HP:0002878)2.86435566
22Increased serum pyruvate (HP:0003542)2.71541282
23Abnormality of the pancreatic islet cells (HP:0006476)2.69334091
24Abnormality of endocrine pancreas physiology (HP:0012093)2.69334091
25Reduced antithrombin III activity (HP:0001976)2.68744053
26Abnormal protein glycosylation (HP:0012346)2.59696100
27Abnormal glycosylation (HP:0012345)2.59696100
28Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.59696100
29Abnormal protein N-linked glycosylation (HP:0012347)2.59696100
30Abnormality of the labia minora (HP:0012880)2.54974829
31Renal Fanconi syndrome (HP:0001994)2.54613102
32Hyperinsulinemic hypoglycemia (HP:0000825)2.52247978
33Colon cancer (HP:0003003)2.52201629
34Abnormality of glycolysis (HP:0004366)2.51441331
35Methylmalonic acidemia (HP:0002912)2.46839095
36Abnormality of the anterior horn cell (HP:0006802)2.46777622
37Degeneration of anterior horn cells (HP:0002398)2.46777622
38Exercise intolerance (HP:0003546)2.40978614
39CNS demyelination (HP:0007305)2.38642645
40Aplastic anemia (HP:0001915)2.37844694
41Abnormality of methionine metabolism (HP:0010901)2.35768468
42Ketoacidosis (HP:0001993)2.33791571
43Medial flaring of the eyebrow (HP:0010747)2.29600593
44Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.25388976
45Lethargy (HP:0001254)2.25290076
46Hypoglycemic coma (HP:0001325)2.24417365
47Neoplasm of the adrenal gland (HP:0100631)2.23140826
48Hypothermia (HP:0002045)2.22490929
49Increased intramyocellular lipid droplets (HP:0012240)2.20502455
50Methylmalonic aciduria (HP:0012120)2.13949097
51Ependymoma (HP:0002888)2.12803167
52Hypoglycemic seizures (HP:0002173)2.12730457
53Hyperglycinemia (HP:0002154)2.12661541
54Agnosia (HP:0010524)2.10822173
55Abnormality of aspartate family amino acid metabolism (HP:0010899)2.07671933
56Leukodystrophy (HP:0002415)2.07632509
57Optic disc pallor (HP:0000543)2.06513488
58Symptomatic seizures (HP:0011145)2.05326908
59Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.04996428
60Medulloblastoma (HP:0002885)2.04202596
61Hyperglycemia (HP:0003074)1.98288204
62Abnormality of serum amino acid levels (HP:0003112)1.96643469
63Atrophy/Degeneration involving motor neurons (HP:0007373)1.96472718
64Short tibia (HP:0005736)1.92691655
65Congenital primary aphakia (HP:0007707)1.91466292
66Abnormality of alanine metabolism (HP:0010916)1.91289133
67Hyperalaninemia (HP:0003348)1.91289133
68Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.91289133
69Aplasia/hypoplasia of the uterus (HP:0008684)1.90860242
70Abnormality of serine family amino acid metabolism (HP:0010894)1.89892016
71Abnormality of glycine metabolism (HP:0010895)1.89892016
72Volvulus (HP:0002580)1.88805512
73Prominent metopic ridge (HP:0005487)1.88376540
74Emotional lability (HP:0000712)1.88349807
75Abnormality of the ileum (HP:0001549)1.87319200
76Increased muscle lipid content (HP:0009058)1.86431384
77Generalized aminoaciduria (HP:0002909)1.84120731
78Nephrogenic diabetes insipidus (HP:0009806)1.82855265
79Hyperglycinuria (HP:0003108)1.81966838
80Abnormality of aromatic amino acid family metabolism (HP:0004338)1.80278548
81Exertional dyspnea (HP:0002875)1.79086774
82Abnormality of the metopic suture (HP:0005556)1.75184914
83Multiple enchondromatosis (HP:0005701)1.74972102
84Meckel diverticulum (HP:0002245)1.73322354
85Hypoproteinemia (HP:0003075)1.71938789
86Abnormality of the preputium (HP:0100587)1.71446304
87Abnormality of urine glucose concentration (HP:0011016)1.71176840
88Glycosuria (HP:0003076)1.71176840
89Shoulder girdle muscle weakness (HP:0003547)1.70855522
90Gait imbalance (HP:0002141)1.68070242
91Tongue fasciculations (HP:0001308)1.67995230
92Abnormal lung lobation (HP:0002101)1.66901439
93Median cleft lip (HP:0000161)1.66517649
94Abnormality of the heme biosynthetic pathway (HP:0010472)1.65576314
95Abnormality of dicarboxylic acid metabolism (HP:0010995)1.65337802
96Dicarboxylic aciduria (HP:0003215)1.65337802
97Abnormality of the fetal cardiovascular system (HP:0010948)1.64948752
98Abnormal umbilical cord blood vessels (HP:0011403)1.64948752
99Single umbilical artery (HP:0001195)1.64948752
100Posterior subcapsular cataract (HP:0007787)1.64895352

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K23.36290797
2MST43.36000827
3EIF2AK33.09212610
4MAP3K123.01646043
5BUB12.99412736
6VRK22.97382023
7PBK2.87086657
8SRPK12.85747464
9BCKDK2.59360406
10NEK12.52450003
11EIF2AK12.37940411
12ZAK2.34864494
13TRIM282.22960039
14NME22.06845714
15CSNK1G31.96176520
16STK161.93100825
17WEE11.85790410
18PLK31.83952100
19TSSK61.83917114
20TTK1.83182057
21CSNK1G11.79754757
22ERBB31.79010982
23VRK11.76158601
24BCR1.71254236
25FRK1.63234094
26CSNK1A1L1.60945159
27CSNK1G21.60229126
28WNK31.56473116
29CCNB11.43604726
30BRSK21.30320360
31MKNK11.28199836
32SCYL21.27213516
33PLK41.24643792
34LIMK11.22442997
35NUAK11.21175659
36CDC71.20082533
37PLK11.15758582
38TESK21.14603717
39TESK11.07074038
40PDK20.98174945
41PAK40.97866676
42DAPK10.97465714
43PASK0.93766952
44PINK10.93459369
45MKNK20.92826184
46MAP3K40.92333678
47STK38L0.90094964
48KDR0.89680724
49PLK20.84549591
50RPS6KA40.82175359
51BMPR1B0.80547195
52MYLK0.79515365
53ADRBK20.78766356
54EIF2AK20.76660800
55ATR0.76004124
56AURKB0.75800775
57GRK10.74819028
58ACVR1B0.72875764
59MAP2K70.68015924
60TAF10.67796084
61BRSK10.67113719
62TLK10.59653188
63MAPK130.59642684
64DYRK20.58989309
65FER0.58916393
66ATM0.58803521
67PHKG10.58778063
68PHKG20.58778063
69AURKA0.56924660
70CSNK2A10.56845769
71CLK10.56670579
72ILK0.56466164
73ERBB40.55876292
74PRKCE0.47244187
75CSNK2A20.45248694
76RPS6KA50.40859215
77FLT30.39786203
78CSNK1A10.39619357
79CHEK20.38412552
80CHEK10.37406508
81PRKCI0.36647723
82EPHA40.36068009
83STK30.35898358
84MATK0.34837869
85MAPKAPK50.31829938
86DAPK30.31271878
87PRKD30.30973332
88STK240.29258960
89PIM20.29158114
90CDK70.28700075
91OXSR10.28579497
92DYRK30.28177308
93CSNK1D0.27890800
94INSRR0.27765682
95TIE10.27466406
96ABL20.27117371
97TAOK30.26799498
98MAP3K50.26449606
99CDK140.26158769
100TEC0.22144589

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.29297497
2Protein export_Homo sapiens_hsa030603.41022028
3Oxidative phosphorylation_Homo sapiens_hsa001902.82392523
4Non-homologous end-joining_Homo sapiens_hsa034502.72821020
5RNA polymerase_Homo sapiens_hsa030202.66191291
6Mismatch repair_Homo sapiens_hsa034302.54429393
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.46926570
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.36494529
9DNA replication_Homo sapiens_hsa030302.30499307
10Parkinsons disease_Homo sapiens_hsa050122.22299127
11Propanoate metabolism_Homo sapiens_hsa006402.07286481
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.05154388
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.05038082
14Fatty acid elongation_Homo sapiens_hsa000621.95551953
15Basal transcription factors_Homo sapiens_hsa030221.93729636
16Base excision repair_Homo sapiens_hsa034101.87977074
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.86104954
18Sulfur metabolism_Homo sapiens_hsa009201.85610845
19Homologous recombination_Homo sapiens_hsa034401.83616238
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.83323886
21RNA transport_Homo sapiens_hsa030131.80512511
22Nucleotide excision repair_Homo sapiens_hsa034201.79416139
23Fanconi anemia pathway_Homo sapiens_hsa034601.73938965
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.71081561
25Pyrimidine metabolism_Homo sapiens_hsa002401.70874803
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.70345648
27One carbon pool by folate_Homo sapiens_hsa006701.69654089
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.62544463
29Spliceosome_Homo sapiens_hsa030401.61500011
30Huntingtons disease_Homo sapiens_hsa050161.55482318
31Steroid biosynthesis_Homo sapiens_hsa001001.52750904
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.50837605
33Collecting duct acid secretion_Homo sapiens_hsa049661.48128891
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44632444
35RNA degradation_Homo sapiens_hsa030181.43442283
36Folate biosynthesis_Homo sapiens_hsa007901.37322813
37Maturity onset diabetes of the young_Homo sapiens_hsa049501.31784112
38Purine metabolism_Homo sapiens_hsa002301.28296915
39Alzheimers disease_Homo sapiens_hsa050101.24068108
40Glutathione metabolism_Homo sapiens_hsa004801.23500274
41Selenocompound metabolism_Homo sapiens_hsa004501.21301758
42Pyruvate metabolism_Homo sapiens_hsa006201.20404206
43Carbon metabolism_Homo sapiens_hsa012001.19605902
44Cell cycle_Homo sapiens_hsa041101.09760735
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.03279616
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.01806096
47Peroxisome_Homo sapiens_hsa041461.00656027
48Butanoate metabolism_Homo sapiens_hsa006501.00351743
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.99285074
50Vitamin B6 metabolism_Homo sapiens_hsa007500.98575769
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97456290
52Biosynthesis of amino acids_Homo sapiens_hsa012300.91806444
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.91451561
54Fatty acid metabolism_Homo sapiens_hsa012120.91384256
55Vibrio cholerae infection_Homo sapiens_hsa051100.88162524
56Metabolic pathways_Homo sapiens_hsa011000.84608628
57Ribosome_Homo sapiens_hsa030100.84404681
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83031768
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.82922337
60Phototransduction_Homo sapiens_hsa047440.82586719
61Regulation of autophagy_Homo sapiens_hsa041400.82237201
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75705998
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.71068281
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.70206571
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67589339
66N-Glycan biosynthesis_Homo sapiens_hsa005100.67235895
67Oocyte meiosis_Homo sapiens_hsa041140.64981845
68Pentose phosphate pathway_Homo sapiens_hsa000300.63943277
69Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62709146
70mRNA surveillance pathway_Homo sapiens_hsa030150.62084021
71Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58693816
72beta-Alanine metabolism_Homo sapiens_hsa004100.56983370
73p53 signaling pathway_Homo sapiens_hsa041150.56332277
74Rheumatoid arthritis_Homo sapiens_hsa053230.55824863
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.49710202
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49425362
77Fatty acid degradation_Homo sapiens_hsa000710.48022754
78Legionellosis_Homo sapiens_hsa051340.45917411
79Primary bile acid biosynthesis_Homo sapiens_hsa001200.45314739
80Tryptophan metabolism_Homo sapiens_hsa003800.43490387
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43140789
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39905735
83Cardiac muscle contraction_Homo sapiens_hsa042600.39421494
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37414771
85Caffeine metabolism_Homo sapiens_hsa002320.36843612
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35739852
87Epstein-Barr virus infection_Homo sapiens_hsa051690.33204420
88Synaptic vesicle cycle_Homo sapiens_hsa047210.30362830
89Type I diabetes mellitus_Homo sapiens_hsa049400.30021856
90Sphingolipid metabolism_Homo sapiens_hsa006000.28446000
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27681381
92Shigellosis_Homo sapiens_hsa051310.26801154
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.23433047
94Galactose metabolism_Homo sapiens_hsa000520.23317117
95Glycosaminoglycan degradation_Homo sapiens_hsa005310.20581943
96Fructose and mannose metabolism_Homo sapiens_hsa000510.20467640
97Arginine and proline metabolism_Homo sapiens_hsa003300.20437702
98Lysosome_Homo sapiens_hsa041420.18668105
99Tyrosine metabolism_Homo sapiens_hsa003500.17216793
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.15712828

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