ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	9.24935117
2	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	8.31526705
3	positive regulation of interleukin-17 production (GO:0032740)	6.84094753
4	regulation of regulatory T cell differentiation (GO:0045589)	6.23236202
5	negative regulation of B cell apoptotic process (GO:0002903)	5.85783409
6	purine deoxyribonucleotide catabolic process (GO:0009155)	5.72212760
7	base-excision repair, AP site formation (GO:0006285)	5.01685237
8	regulation of isotype switching to IgG isotypes (GO:0048302)	4.87680228
9	respiratory chain complex IV assembly (GO:0008535)	4.42456751
10	proteasome assembly (GO:0043248)	4.31267942
11	protein deneddylation (GO:0000338)	4.28413578
12	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.27796280
13	regulation of interleukin-17 production (GO:0032660)	4.15167252
14	cullin deneddylation (GO:0010388)	4.02164713
15	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.99041023
16	ATP synthesis coupled proton transport (GO:0015986)	3.99041023
17	positive regulation of isotype switching (GO:0045830)	3.89320418
18	one-carbon compound transport (GO:0019755)	3.88294647
19	response to pheromone (GO:0019236)	3.87010307
20	positive regulation of DNA recombination (GO:0045911)	3.85142269
21	protein complex biogenesis (GO:0070271)	3.84472665
22	cytochrome complex assembly (GO:0017004)	3.78340562
23	regulation of immunoglobulin secretion (GO:0051023)	3.74955447
24	regulation of B cell apoptotic process (GO:0002902)	3.73523331
25	postreplication repair (GO:0006301)	3.62926969
26	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.62267902
27	mitochondrial respiratory chain complex assembly (GO:0033108)	3.61921460
28	neutrophil mediated immunity (GO:0002446)	3.55127988
29	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.48304183
30	keratinocyte development (GO:0003334)	3.41818011
31	deoxyribonucleotide catabolic process (GO:0009264)	3.36263676
32	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.31339435
33	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.31339435
34	NADH dehydrogenase complex assembly (GO:0010257)	3.31339435
35	phosphorylated carbohydrate dephosphorylation (GO:0046838)	3.29402057
36	inositol phosphate dephosphorylation (GO:0046855)	3.29402057
37	positive regulation of activated T cell proliferation (GO:0042104)	3.26840354
38	negative regulation of heart contraction (GO:0045822)	3.26267332
39	oxidative phosphorylation (GO:0006119)	3.25083420
40	spliceosomal complex assembly (GO:0000245)	3.24997132
41	negative regulation of growth of symbiont in host (GO:0044130)	3.23267899
42	negative regulation of growth of symbiont involved in interaction with host (GO:0044146)	3.23267899
43	modulation of growth of symbiont involved in interaction with host (GO:0044144)	3.23267899
44	regulation of growth of symbiont in host (GO:0044126)	3.23267899
45	purine deoxyribonucleotide metabolic process (GO:0009151)	3.20400978
46	deoxyribose phosphate catabolic process (GO:0046386)	3.18899019
47	respiratory electron transport chain (GO:0022904)	3.18373627
48	disruption of cells of other organism involved in symbiotic interaction (GO:0051818)	3.15192360
49	killing of cells in other organism involved in symbiotic interaction (GO:0051883)	3.15192360
50	electron transport chain (GO:0022900)	3.14816440
51	positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)	3.10734179
52	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.07912409
53	chaperone-mediated protein transport (GO:0072321)	3.03262637
54	inositol phosphate catabolic process (GO:0071545)	3.03062841
55	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.02079183
56	protein neddylation (GO:0045116)	3.01913374
57	B cell mediated immunity (GO:0019724)	3.01593867
58	molting cycle (GO:0042303)	2.96006634
59	hair cycle (GO:0042633)	2.96006634
60	flavonoid metabolic process (GO:0009812)	2.94970079
61	GTP biosynthetic process (GO:0006183)	2.92825226
62	regulation of skeletal muscle contraction (GO:0014819)	2.91014906
63	protein heterotetramerization (GO:0051290)	2.90869005
64	regulation of helicase activity (GO:0051095)	2.90868506
65	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.90840198
66	ribonucleoprotein complex disassembly (GO:0032988)	2.90063611
67	negative regulation of lymphocyte apoptotic process (GO:0070229)	2.88678829
68	signal peptide processing (GO:0006465)	2.86623160
69	regulation of tyrosine phosphorylation of STAT protein (GO:0042509)	2.86573581
70	regulation of germinal center formation (GO:0002634)	2.85219571
71	hydrogen ion transmembrane transport (GO:1902600)	2.84766601
72	mitochondrial fragmentation involved in apoptotic process (GO:0043653)	2.82921402
73	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.79530515
74	formation of translation preinitiation complex (GO:0001731)	2.79513881
75	response to xenobiotic stimulus (GO:0009410)	2.79357176
76	adenosine metabolic process (GO:0046085)	2.78458376
77	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.78064765
78	response to gravity (GO:0009629)	2.77102093
79	protein localization to endoplasmic reticulum (GO:0070972)	2.75398108
80	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.73949303
81	translation (GO:0006412)	2.73549490
82	negative regulation of membrane potential (GO:0045837)	2.71894022
83	cotranslational protein targeting to membrane (GO:0006613)	2.71883759
84	prenylation (GO:0097354)	2.70598969
85	protein prenylation (GO:0018342)	2.70598969
86	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.70380331
87	polyol catabolic process (GO:0046174)	2.69395643
88	tRNA processing (GO:0008033)	2.68785560
89	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.68768688
90	viral protein processing (GO:0019082)	2.66556523
91	protein targeting to ER (GO:0045047)	2.66485574
92	organelle disassembly (GO:1903008)	2.64654309
93	translesion synthesis (GO:0019985)	2.63690726
94	proton transport (GO:0015992)	2.62459905
95	hydrogen transport (GO:0006818)	2.61840740
96	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.60574096
97	myeloid leukocyte mediated immunity (GO:0002444)	2.60426346
98	natural killer cell activation (GO:0030101)	2.59099952
99	positive regulation of JAK-STAT cascade (GO:0046427)	2.57876686
100	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.57186327

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.06868716
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.71025339
3	TAF15_26573619_Chip-Seq_HEK293_Human	3.65780752
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.56632292
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.38894902
6	FLI1_27457419_Chip-Seq_LIVER_Mouse	3.37824831
7	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.05877864
8	VDR_22108803_ChIP-Seq_LS180_Human	2.87682305
9	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.75909459
10	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.70697595
11	ELK1_19687146_ChIP-ChIP_HELA_Human	2.61262307
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.49293807
13	VDR_23849224_ChIP-Seq_CD4+_Human	2.46509670
14	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.41378291
15	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.37852869
16	FUS_26573619_Chip-Seq_HEK293_Human	2.37851338
17	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.32729812
18	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.24122268
19	EWS_26573619_Chip-Seq_HEK293_Human	2.21165469
20	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.20994677
21	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.20518672
22	ZNF274_21170338_ChIP-Seq_K562_Hela	2.16092879
23	FOXP3_21729870_ChIP-Seq_TREG_Human	2.03146098
24	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.00730102
25	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.00458247
26	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.94674593
27	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.85758440
28	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.82850936
29	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.81941421
30	IGF1R_20145208_ChIP-Seq_DFB_Human	1.78016768
31	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.76559812
32	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.67738646
33	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.61565146
34	EZH2_22144423_ChIP-Seq_EOC_Human	1.61177219
35	MYC_18940864_ChIP-ChIP_HL60_Human	1.60900618
36	P300_19829295_ChIP-Seq_ESCs_Human	1.60521972
37	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.57648330
38	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.55058494
39	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.50722864
40	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.41851155
41	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.37594020
42	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.35759018
43	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.34741522
44	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.32454702
45	ER_23166858_ChIP-Seq_MCF-7_Human	1.32119936
46	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.31621005
47	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.30734714
48	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.28278560
49	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.26580928
50	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.26332068
51	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.25103915
52	DCP1A_22483619_ChIP-Seq_HELA_Human	1.23610850
53	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.22899142
54	TTF2_22483619_ChIP-Seq_HELA_Human	1.20521273
55	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.18409919
56	TP53_22573176_ChIP-Seq_HFKS_Human	1.17466803
57	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.17433047
58	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.17433047
59	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.15922626
60	GBX2_23144817_ChIP-Seq_PC3_Human	1.10381898
61	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.09976703
62	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.08353612
63	AR_20517297_ChIP-Seq_VCAP_Human	1.08064992
64	SOX2_19829295_ChIP-Seq_ESCs_Human	1.07933065
65	NANOG_19829295_ChIP-Seq_ESCs_Human	1.07933065
66	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.07266988
67	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.06754203
68	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.06218854
69	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.04816383
70	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.04688578
71	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.03686654
72	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.02826380
73	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.01961525
74	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.01762465
75	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.01112716
76	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	0.98477958
77	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.96860524
78	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.96618254
79	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.96274204
80	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.96116727
81	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.95533613
82	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.95153227
83	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.94906155
84	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.94814682
85	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.94800716
86	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.94188078
87	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.93817892
88	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.93731386
89	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.93269085
90	SOX2_18555785_Chip-Seq_ESCs_Mouse	0.92101990
91	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.91779583
92	GATA3_26560356_Chip-Seq_TH2_Human	0.91660735
93	P300_18555785_Chip-Seq_ESCs_Mouse	0.91029498
94	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.90952248
95	P53_22387025_ChIP-Seq_ESCs_Mouse	0.90524230
96	BCAT_22108803_ChIP-Seq_LS180_Human	0.90034890
97	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.89428538
98	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.88922730
99	CBP_20019798_ChIP-Seq_JUKART_Human	0.88922730
100	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.88876764

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001835_abnormal_antigen_presentation	3.50793957
2	MP0005671_abnormal_response_to	3.46554168
3	MP0001853_heart_inflammation	3.40531526
4	MP0001529_abnormal_vocalization	3.27829144
5	MP0000465_gastrointestinal_hemorrhage	3.02977185
6	MP0004145_abnormal_muscle_electrophysio	3.01253146
7	MP0002102_abnormal_ear_morphology	2.96711265
8	MP0008789_abnormal_olfactory_epithelium	2.47689606
9	MP0003646_muscle_fatigue	2.38793624
10	MP0001919_abnormal_reproductive_system	2.35721355
11	MP0004142_abnormal_muscle_tone	2.30308324
12	MP0005367_renal/urinary_system_phenotyp	2.25207357
13	MP0000516_abnormal_urinary_system	2.25207357
14	MP0005646_abnormal_pituitary_gland	2.17685764
15	MP0008872_abnormal_physiological_respon	2.16877552
16	MP0002234_abnormal_pharynx_morphology	2.05173226
17	MP0002822_catalepsy	2.05032506
18	MP0005499_abnormal_olfactory_system	2.04048563
19	MP0005394_taste/olfaction_phenotype	2.04048563
20	MP0008058_abnormal_DNA_repair	1.98950003
21	MP0005075_abnormal_melanosome_morpholog	1.94136934
22	MP0003786_premature_aging	1.93829938
23	MP0006035_abnormal_mitochondrial_morpho	1.88442782
24	MP0006072_abnormal_retinal_apoptosis	1.84724135
25	MP0003195_calcinosis	1.79343192
26	MP0006292_abnormal_olfactory_placode	1.77493446
27	MP0004043_abnormal_pH_regulation	1.76366116
28	MP0005645_abnormal_hypothalamus_physiol	1.68516249
29	MP0002166_altered_tumor_susceptibility	1.60632842
30	MP0003724_increased_susceptibility_to	1.59517760
31	MP0003300_gastrointestinal_ulcer	1.56453107
32	MP0003718_maternal_effect	1.54770098
33	MP0002837_dystrophic_cardiac_calcinosis	1.53488363
34	MP0003890_abnormal_embryonic-extraembry	1.42812839
35	MP0002148_abnormal_hypersensitivity_rea	1.40942867
36	MP0002163_abnormal_gland_morphology	1.40862311
37	MP0003806_abnormal_nucleotide_metabolis	1.35066919
38	MP0003186_abnormal_redox_activity	1.34243137
39	MP0005389_reproductive_system_phenotype	1.33995198
40	MP0000631_abnormal_neuroendocrine_gland	1.33543063
41	MP0009697_abnormal_copulation	1.33458505
42	MP0005636_abnormal_mineral_homeostasis	1.32547454
43	MP0006036_abnormal_mitochondrial_physio	1.30303452
44	MP0004957_abnormal_blastocyst_morpholog	1.30221061
45	MP0004036_abnormal_muscle_relaxation	1.29157971
46	MP0004885_abnormal_endolymph	1.28572382
47	MP0005551_abnormal_eye_electrophysiolog	1.26527990
48	MP0002006_tumorigenesis	1.24799156
49	MP0002090_abnormal_vision	1.18093069
50	MP0001440_abnormal_grooming_behavior	1.17188547
51	MP0010386_abnormal_urinary_bladder	1.16430039
52	MP0001756_abnormal_urination	1.14369094
53	MP0002095_abnormal_skin_pigmentation	1.13859336
54	MP0001905_abnormal_dopamine_level	1.13120062
55	MP0003866_abnormal_defecation	1.12983946
56	MP0004134_abnormal_chest_morphology	1.12517664
57	MP0009379_abnormal_foot_pigmentation	1.12384404
58	MP0004147_increased_porphyrin_level	1.08862685
59	MP0001765_abnormal_ion_homeostasis	1.07726095
60	MP0003283_abnormal_digestive_organ	1.04988277
61	MP0001485_abnormal_pinna_reflex	1.03764470
62	MP0000604_amyloidosis	1.02775027
63	MP0001968_abnormal_touch/_nociception	1.02069173
64	MP0005000_abnormal_immune_tolerance	1.01010922
65	MP0002736_abnormal_nociception_after	0.97081153
66	MP0000049_abnormal_middle_ear	0.96552753
67	MP0009785_altered_susceptibility_to	0.92834925
68	MP0000372_irregular_coat_pigmentation	0.91310846
69	MP0004924_abnormal_behavior	0.90702929
70	MP0005386_behavior/neurological_phenoty	0.90702929
71	MP0009764_decreased_sensitivity_to	0.90020407
72	MP0002277_abnormal_respiratory_mucosa	0.89763864
73	MP0002735_abnormal_chemical_nociception	0.87533565
74	MP0002272_abnormal_nervous_system	0.87103474
75	MP0004084_abnormal_cardiac_muscle	0.86673060
76	MP0003221_abnormal_cardiomyocyte_apopto	0.83748033
77	MP0001970_abnormal_pain_threshold	0.83624329
78	MP0002332_abnormal_exercise_endurance	0.83085293
79	MP0002282_abnormal_trachea_morphology	0.82687991
80	MP0004782_abnormal_surfactant_physiolog	0.79053437
81	MP0001984_abnormal_olfaction	0.77595746
82	MP0000685_abnormal_immune_system	0.77119810
83	MP0010094_abnormal_chromosome_stability	0.73842543
84	MP0008995_early_reproductive_senescence	0.73156325
85	MP0003878_abnormal_ear_physiology	0.72050091
86	MP0005377_hearing/vestibular/ear_phenot	0.72050091
87	MP0001661_extended_life_span	0.71906223
88	MP0005025_abnormal_response_to	0.71070184
89	MP0005332_abnormal_amino_acid	0.67916818
90	MP0001800_abnormal_humoral_immune	0.67848332
91	MP0002693_abnormal_pancreas_physiology	0.65974409
92	MP0003880_abnormal_central_pattern	0.65022461
93	MP0008873_increased_physiological_sensi	0.64870578
94	MP0002177_abnormal_outer_ear	0.64264897
95	MP0002420_abnormal_adaptive_immunity	0.62940485
96	MP0009250_abnormal_appendicular_skeleto	0.62588972
97	MP0000534_abnormal_ureter_morphology	0.62451372
98	MP0003011_delayed_dark_adaptation	0.61997479
99	MP0002405_respiratory_system_inflammati	0.61664341
100	MP0001486_abnormal_startle_reflex	0.61566902

Predicted human phenotypes

Rank	Gene Set	Z-score
1	3-Methylglutaconic aciduria (HP:0003535)	5.43828112
2	Congenital, generalized hypertrichosis (HP:0004540)	4.36048528
3	Hepatocellular necrosis (HP:0001404)	3.70651228
4	Abolished electroretinogram (ERG) (HP:0000550)	3.54605400
5	Mitochondrial inheritance (HP:0001427)	3.39661821
6	Volvulus (HP:0002580)	3.26075866
7	Hepatic necrosis (HP:0002605)	3.23234992
8	Increased CSF lactate (HP:0002490)	3.22447865
9	Acute necrotizing encephalopathy (HP:0006965)	3.20069485
10	Microvesicular hepatic steatosis (HP:0001414)	3.15214077
11	Pancreatic islet-cell hyperplasia (HP:0004510)	3.07516692
12	Increased hepatocellular lipid droplets (HP:0006565)	2.99222708
13	Abnormality of the ileum (HP:0001549)	2.92789414
14	Hypomagnesemia (HP:0002917)	2.87399445
15	Abnormal mitochondria in muscle tissue (HP:0008316)	2.87082010
16	Abnormality of alanine metabolism (HP:0010916)	2.85852907
17	Hyperalaninemia (HP:0003348)	2.85852907
18	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.85852907
19	Tetany (HP:0001281)	2.84452157
20	Aqueductal stenosis (HP:0002410)	2.82591723
21	Exertional dyspnea (HP:0002875)	2.68683669
22	Abnormality of the fetal cardiovascular system (HP:0010948)	2.64900404
23	Abnormal umbilical cord blood vessels (HP:0011403)	2.64900404
24	Single umbilical artery (HP:0001195)	2.64900404
25	Progressive macrocephaly (HP:0004481)	2.62586590
26	Acute encephalopathy (HP:0006846)	2.61251698
27	Aplastic anemia (HP:0001915)	2.59883306
28	Meckel diverticulum (HP:0002245)	2.54014392
29	Abnormality of the anterior horn cell (HP:0006802)	2.50485449
30	Degeneration of anterior horn cells (HP:0002398)	2.50485449
31	Increased circulating renin level (HP:0000848)	2.38390731
32	Lipid accumulation in hepatocytes (HP:0006561)	2.33775010
33	Hyperactive renin-angiotensin system (HP:0000841)	2.31905820
34	Renal Fanconi syndrome (HP:0001994)	2.27998018
35	Abnormality of magnesium homeostasis (HP:0004921)	2.23988158
36	Oral leukoplakia (HP:0002745)	2.23983415
37	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.17336653
38	Agnosia (HP:0010524)	2.17229772
39	Pancreatic cysts (HP:0001737)	2.11774084
40	Increased serum lactate (HP:0002151)	2.11637223
41	Molar tooth sign on MRI (HP:0002419)	2.11595791
42	Abnormality of midbrain morphology (HP:0002418)	2.11595791
43	Intestinal atresia (HP:0011100)	2.10100434
44	Aplasia/hypoplasia of the uterus (HP:0008684)	2.07605044
45	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.06393982
46	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.04796802
47	Absent thumb (HP:0009777)	2.01504272
48	Meningioma (HP:0002858)	1.99876327
49	Broad alveolar ridges (HP:0000187)	1.98492389
50	Hypoproteinemia (HP:0003075)	1.97123657
51	Leukodystrophy (HP:0002415)	1.95271523
52	Aplasia cutis congenita (HP:0001057)	1.94397683
53	Abnormality of the prostate (HP:0008775)	1.94289449
54	Atrophy/Degeneration involving motor neurons (HP:0007373)	1.93615859
55	Porencephaly (HP:0002132)	1.93073446
56	Delayed CNS myelination (HP:0002188)	1.92842613
57	Amaurosis fugax (HP:0100576)	1.92326768
58	Abnormality of the preputium (HP:0100587)	1.92257577
59	Lactic acidosis (HP:0003128)	1.91830508
60	Bifid tongue (HP:0010297)	1.90326641
61	Spontaneous abortion (HP:0005268)	1.88580086
62	Respiratory failure (HP:0002878)	1.88447477
63	Asplenia (HP:0001746)	1.87333460
64	Microretrognathia (HP:0000308)	1.87022226
65	Woolly hair (HP:0002224)	1.85678365
66	Increased intramyocellular lipid droplets (HP:0012240)	1.84159810
67	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.83400179
68	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.82278293
69	Polydipsia (HP:0001959)	1.81228176
70	Abnormal drinking behavior (HP:0030082)	1.81228176
71	Poor speech (HP:0002465)	1.80778462
72	Respiratory difficulties (HP:0002880)	1.80645602
73	Neoplasm of the peripheral nervous system (HP:0100007)	1.80252289
74	Hypokalemic alkalosis (HP:0001949)	1.80177429
75	Colon cancer (HP:0003003)	1.79859939
76	Premature graying of hair (HP:0002216)	1.79442339
77	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.79137201
78	Pulmonary fibrosis (HP:0002206)	1.77189389
79	Fibular aplasia (HP:0002990)	1.76913396
80	Cerebral edema (HP:0002181)	1.75659375
81	Gastrointestinal infarctions (HP:0005244)	1.74519620
82	Severe combined immunodeficiency (HP:0004430)	1.74049057
83	Nephronophthisis (HP:0000090)	1.72632623
84	Abnormality of chromosome stability (HP:0003220)	1.72179556
85	Exercise intolerance (HP:0003546)	1.72168469
86	Large eyes (HP:0001090)	1.71898538
87	B lymphocytopenia (HP:0010976)	1.70398224
88	Retinal dysplasia (HP:0007973)	1.69999154
89	Pendular nystagmus (HP:0012043)	1.69812295
90	Conjunctival hamartoma (HP:0100780)	1.69225280
91	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.68720745
92	Abnormality of the pancreatic islet cells (HP:0006476)	1.68436051
93	Abnormality of endocrine pancreas physiology (HP:0012093)	1.68436051
94	Medial flaring of the eyebrow (HP:0010747)	1.68082846
95	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.66335255
96	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.66206449
97	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.66206449
98	Autoamputation (HP:0001218)	1.64953293
99	Clubbing of toes (HP:0100760)	1.64908299
100	Brittle hair (HP:0002299)	1.64238296

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K12	6.84222954
2	WNK3	3.31364410
3	MYLK	2.66575492
4	PIK3CG	2.56164981
5	NME2	2.24051158
6	EIF2AK3	2.21689048
7	PASK	2.18140383
8	TXK	2.10549282
9	MST4	2.08198969
10	EIF2AK1	2.07031064
11	TEC	2.06755551
12	STK16	1.95514560
13	SRPK1	1.95378416
14	INSRR	1.94207846
15	CDK19	1.93645401
16	PAK4	1.87425587
17	RPS6KA4	1.84594108
18	TAOK3	1.82017082
19	BCKDK	1.79951393
20	BMPR1B	1.59905009
21	NUAK1	1.54106723
22	MUSK	1.44772276
23	ILK	1.43824983
24	MAP2K7	1.41383770
25	MAP3K4	1.36424981
26	CDK3	1.35570633
27	GRK1	1.33615040
28	FRK	1.33592744
29	DAPK1	1.29117917
30	ZAK	1.26767610
31	MKNK2	1.18095494
32	PHKG1	1.15784573
33	PHKG2	1.15784573
34	ERBB3	1.12710504
35	BCR	1.11708801
36	TNIK	1.11110740
37	DAPK3	1.10694319
38	CCNB1	1.08429189
39	MAPK13	1.06969123
40	KDR	1.06887122
41	ITK	1.06549734
42	ADRBK2	0.99697526
43	PKN1	0.98200898
44	BUB1	0.94608864
45	VRK2	0.89648206
46	OBSCN	0.89082080
47	BTK	0.88414322
48	TSSK6	0.86907829
49	TNK2	0.84524232
50	RPS6KA5	0.83708544
51	ATR	0.82839867
52	DYRK2	0.81641746
53	JAK3	0.77238989
54	WNK1	0.76718974
55	CSK	0.73334432
56	VRK1	0.69123389
57	LYN	0.66016085
58	MAP2K4	0.65951421
59	TIE1	0.65199615
60	CLK1	0.64200574
61	GRK6	0.63292544
62	STK38L	0.61372037
63	SGK2	0.59458194
64	ROCK2	0.58267295
65	EIF2AK2	0.55400268
66	NME1	0.54127051
67	TRPM7	0.54116127
68	MKNK1	0.53248006
69	CAMK1	0.53167704
70	TRIM28	0.53004759
71	CAMK2G	0.51464132
72	ACVR1B	0.50395574
73	PDK2	0.47753997
74	EGFR	0.45830581
75	PLK3	0.45757552
76	BMPR2	0.45273774
77	SYK	0.45246791
78	ERBB4	0.45017779
79	CSNK2A1	0.42085217
80	CSNK2A2	0.40998714
81	UHMK1	0.38051043
82	SGK223	0.37829050
83	SGK494	0.37829050
84	LCK	0.37522280
85	TAOK2	0.36032562
86	PRKCD	0.35589338
87	IKBKB	0.35282439
88	MAP3K5	0.35029922
89	IGF1R	0.34541388
90	PRKCE	0.33783933
91	HCK	0.32673574
92	PRKACA	0.32377746
93	IRAK1	0.31718806
94	ADRBK1	0.30964418
95	CHEK2	0.30484750
96	FES	0.28248421
97	WNK4	0.27746635
98	AURKB	0.27429901
99	JAK1	0.27320819
100	CSNK1A1	0.26953475

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	4.21137147
2	Asthma_Homo sapiens_hsa05310	4.01814922
3	Proteasome_Homo sapiens_hsa03050	3.57781936
4	Oxidative phosphorylation_Homo sapiens_hsa00190	3.49852483
5	Allograft rejection_Homo sapiens_hsa05330	3.09141605
6	Type I diabetes mellitus_Homo sapiens_hsa04940	3.08292178
7	Graft-versus-host disease_Homo sapiens_hsa05332	2.95149601
8	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.93363818
9	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.81302023
10	Ribosome_Homo sapiens_hsa03010	2.67551772
11	Parkinsons disease_Homo sapiens_hsa05012	2.63321408
12	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.43701111
13	Basal transcription factors_Homo sapiens_hsa03022	2.23042650
14	RNA polymerase_Homo sapiens_hsa03020	1.96729415
15	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.94294292
16	Alzheimers disease_Homo sapiens_hsa05010	1.83647028
17	Huntingtons disease_Homo sapiens_hsa05016	1.72602089
18	Mismatch repair_Homo sapiens_hsa03430	1.65441025
19	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.64607879
20	Fanconi anemia pathway_Homo sapiens_hsa03460	1.60895584
21	Homologous recombination_Homo sapiens_hsa03440	1.57770866
22	RNA degradation_Homo sapiens_hsa03018	1.54181227
23	Rheumatoid arthritis_Homo sapiens_hsa05323	1.50641151
24	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.50119967
25	Spliceosome_Homo sapiens_hsa03040	1.43893782
26	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.40824589
27	Phototransduction_Homo sapiens_hsa04744	1.39452778
28	Cardiac muscle contraction_Homo sapiens_hsa04260	1.33479113
29	RNA transport_Homo sapiens_hsa03013	1.25685912
30	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.17640621
31	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.15172037
32	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.14199035
33	Regulation of autophagy_Homo sapiens_hsa04140	1.13754745
34	Collecting duct acid secretion_Homo sapiens_hsa04966	1.09516183
35	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.08377009
36	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.06091883
37	Antigen processing and presentation_Homo sapiens_hsa04612	0.99599726
38	Nucleotide excision repair_Homo sapiens_hsa03420	0.98239344
39	Legionellosis_Homo sapiens_hsa05134	0.93081721
40	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.91823933
41	Base excision repair_Homo sapiens_hsa03410	0.88417720
42	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.85736617
43	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.85505446
44	Pyrimidine metabolism_Homo sapiens_hsa00240	0.85110478
45	Primary immunodeficiency_Homo sapiens_hsa05340	0.81541161
46	Circadian rhythm_Homo sapiens_hsa04710	0.80576524
47	Viral myocarditis_Homo sapiens_hsa05416	0.79583767
48	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.77983081
49	Retinol metabolism_Homo sapiens_hsa00830	0.77014060
50	Renin-angiotensin system_Homo sapiens_hsa04614	0.76892722
51	Chemical carcinogenesis_Homo sapiens_hsa05204	0.76210558
52	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.73817637
53	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.73035898
54	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.69511235
55	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.69147494
56	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.67439299
57	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.64935600
58	DNA replication_Homo sapiens_hsa03030	0.63781893
59	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.63616368
60	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.62221155
61	Peroxisome_Homo sapiens_hsa04146	0.60815800
62	Olfactory transduction_Homo sapiens_hsa04740	0.55029429
63	Purine metabolism_Homo sapiens_hsa00230	0.53137901
64	Measles_Homo sapiens_hsa05162	0.51803280
65	Glutathione metabolism_Homo sapiens_hsa00480	0.51756354
66	Fat digestion and absorption_Homo sapiens_hsa04975	0.49884984
67	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.45428472
68	Caffeine metabolism_Homo sapiens_hsa00232	0.44738467
69	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.43345346
70	Mineral absorption_Homo sapiens_hsa04978	0.40066696
71	Sulfur metabolism_Homo sapiens_hsa00920	0.40008168
72	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.36994878
73	Herpes simplex infection_Homo sapiens_hsa05168	0.36825293
74	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.36661698
75	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.36522753
76	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.35417413
77	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.34058730
78	Propanoate metabolism_Homo sapiens_hsa00640	0.32778452
79	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.32051670
80	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.31152375
81	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.29421047
82	Leishmaniasis_Homo sapiens_hsa05140	0.28696457
83	Salmonella infection_Homo sapiens_hsa05132	0.28146980
84	Metabolic pathways_Homo sapiens_hsa01100	0.26564986
85	Pancreatic secretion_Homo sapiens_hsa04972	0.26130305
86	Folate biosynthesis_Homo sapiens_hsa00790	0.25624730
87	Phagosome_Homo sapiens_hsa04145	0.24242621
88	One carbon pool by folate_Homo sapiens_hsa00670	0.21948111
89	Linoleic acid metabolism_Homo sapiens_hsa00591	0.20070788
90	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.19475175
91	Vibrio cholerae infection_Homo sapiens_hsa05110	0.18301073
92	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.17958218
93	Nicotine addiction_Homo sapiens_hsa05033	0.17397441
94	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.16430054
95	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.16059399
96	Toxoplasmosis_Homo sapiens_hsa05145	0.15867417
97	GABAergic synapse_Homo sapiens_hsa04727	0.15823837
98	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.15529572
99	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.14183492
100	Oocyte meiosis_Homo sapiens_hsa04114	0.14092975

BTF3L4P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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