BTF3P10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.08151828
2cytidine metabolic process (GO:0046087)5.93460434
3cytidine catabolic process (GO:0006216)5.93460434
4cytidine deamination (GO:0009972)5.93460434
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.50682327
6ribosomal small subunit assembly (GO:0000028)5.35370173
7ribosomal large subunit biogenesis (GO:0042273)5.20775212
8tolerance induction (GO:0002507)5.02593127
9pyrimidine ribonucleoside catabolic process (GO:0046133)4.98414575
10viral transcription (GO:0019083)4.92624271
11positive regulation of gamma-delta T cell activation (GO:0046645)4.84960067
12translational termination (GO:0006415)4.65980456
13ribosomal small subunit biogenesis (GO:0042274)4.53094127
14regulation of interleukin-12 biosynthetic process (GO:0045075)4.22370328
15SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.22227495
16positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.15746472
17cotranslational protein targeting to membrane (GO:0006613)4.12949359
18protein targeting to ER (GO:0045047)4.12004084
19translational elongation (GO:0006414)4.09203469
20regulation of chronic inflammatory response (GO:0002676)4.08799322
21regulation of gamma-delta T cell differentiation (GO:0045586)4.06753168
22sequestering of actin monomers (GO:0042989)4.05973491
23positive regulation of natural killer cell mediated immunity (GO:0002717)4.04045760
24establishment of protein localization to endoplasmic reticulum (GO:0072599)3.89976829
25protein localization to endoplasmic reticulum (GO:0070972)3.87996288
26cytolysis (GO:0019835)3.66603350
27viral life cycle (GO:0019058)3.60219256
28ribonucleoprotein complex biogenesis (GO:0022613)3.60192804
29regulation of cellular respiration (GO:0043457)3.58359724
30positive regulation of uterine smooth muscle contraction (GO:0070474)3.48559776
31energy coupled proton transport, down electrochemical gradient (GO:0015985)3.48343398
32ATP synthesis coupled proton transport (GO:0015986)3.48343398
33cellular protein complex disassembly (GO:0043624)3.45729982
34nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.44546751
35regulation of gamma-delta T cell activation (GO:0046643)3.43303891
36production of molecular mediator involved in inflammatory response (GO:0002532)3.42427255
37regulation of B cell receptor signaling pathway (GO:0050855)3.40169575
38mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.37305220
39positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.36639486
40establishment of protein localization to mitochondrial membrane (GO:0090151)3.36321440
41transcription elongation from RNA polymerase III promoter (GO:0006385)3.34565650
42termination of RNA polymerase III transcription (GO:0006386)3.34565650
43positive regulation of defense response to virus by host (GO:0002230)3.31997022
44protein neddylation (GO:0045116)3.29478776
45negative regulation of cardiac muscle hypertrophy (GO:0010614)3.28278930
46negative T cell selection (GO:0043383)3.27129829
47regulation of natural killer cell mediated immunity (GO:0002715)3.26428538
48regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.26428538
49negative regulation of T cell apoptotic process (GO:0070233)3.25820516
50positive regulation of T cell apoptotic process (GO:0070234)3.21642594
51regulation of regulatory T cell differentiation (GO:0045589)3.20767651
52T cell receptor signaling pathway (GO:0050852)3.13527593
53mast cell activation (GO:0045576)3.13364079
54negative regulation of glycogen biosynthetic process (GO:0045719)3.12182474
55positive regulation of interleukin-8 secretion (GO:2000484)3.11024163
56positive regulation of cell killing (GO:0031343)3.09185503
57positive thymic T cell selection (GO:0045059)3.03781725
58translational initiation (GO:0006413)3.03628341
59positive T cell selection (GO:0043368)3.03017409
60tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.00481879
61RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.00481879
62positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.00021447
63positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.98704181
64purine nucleotide salvage (GO:0032261)2.98165216
65negative regulation of muscle hypertrophy (GO:0014741)2.96922192
66purine-containing compound salvage (GO:0043101)2.94329077
67regulation of leukocyte mediated cytotoxicity (GO:0001910)2.94268683
68antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.93910451
69piRNA metabolic process (GO:0034587)2.93816777
70negative regulation of viral genome replication (GO:0045071)2.91493238
71regulation of activation of Janus kinase activity (GO:0010533)2.90822974
72cellular response to interleukin-6 (GO:0071354)2.90658216
73translation (GO:0006412)2.88915984
74negative regulation by host of viral transcription (GO:0043922)2.87152536
75cellular component biogenesis (GO:0044085)2.83957283
76regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.82510282
77protein complex disassembly (GO:0043241)2.81896562
78activated T cell proliferation (GO:0050798)2.80730345
79positive regulation of humoral immune response (GO:0002922)2.80511286
80galactose catabolic process (GO:0019388)2.78426717
81tachykinin receptor signaling pathway (GO:0007217)2.77848354
82regulation of oxidative stress-induced neuron death (GO:1903203)2.76274962
83negative thymic T cell selection (GO:0045060)2.75570709
84eosinophil chemotaxis (GO:0048245)2.75480779
85protein targeting to membrane (GO:0006612)2.74545846
86positive regulation of B cell differentiation (GO:0045579)2.74164291
87forebrain morphogenesis (GO:0048853)2.74084743
88lymphocyte costimulation (GO:0031294)2.73589687
89regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.72085240
90ribosome biogenesis (GO:0042254)2.72045441
91positive regulation of T cell mediated cytotoxicity (GO:0001916)2.71587411
92positive regulation of alpha-beta T cell proliferation (GO:0046641)2.70568885
93T cell costimulation (GO:0031295)2.68287175
94positive regulation of translational initiation (GO:0045948)2.67949268
95regulation of cell killing (GO:0031341)2.67638579
96macromolecular complex disassembly (GO:0032984)2.66698192
97positive regulation of protein homodimerization activity (GO:0090073)2.66225908
98response to nitrosative stress (GO:0051409)2.65844650
99regulation of T cell apoptotic process (GO:0070232)2.64111676
100positive regulation of interleukin-12 production (GO:0032735)2.64038836

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat7.89834263
2ELF1_17652178_ChIP-ChIP_JURKAT_Human4.48107903
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.83936240
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.47066071
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.35702534
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.24716165
7VDR_22108803_ChIP-Seq_LS180_Human3.05066973
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.90287757
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.71089490
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.70711541
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.48655328
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.47242895
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.10719864
14RUNX_20019798_ChIP-Seq_JUKART_Human2.05567771
15MYB_26560356_Chip-Seq_TH2_Human2.05221715
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.87053290
17VDR_23849224_ChIP-Seq_CD4+_Human1.83150936
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.75683735
19GATA3_26560356_Chip-Seq_TH2_Human1.70301538
20GATA3_27048872_Chip-Seq_THYMUS_Human1.67328033
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.64965094
22STAT4_19710469_ChIP-ChIP_TH1__Mouse1.63430590
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58457039
24KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.53633207
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.53616866
26FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.52128951
27ZNF274_21170338_ChIP-Seq_K562_Hela1.50764801
28TP53_22573176_ChIP-Seq_HFKS_Human1.48627687
29ETS1_20019798_ChIP-Seq_JURKAT_Human1.47414878
30JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.47380597
31HTT_18923047_ChIP-ChIP_STHdh_Human1.45488201
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.43627879
33MYC_18940864_ChIP-ChIP_HL60_Human1.41955053
34TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.40219045
35LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.39835361
36EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.39479931
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.38964171
38RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.38742679
39SCL_19346495_ChIP-Seq_HPC-7_Human1.29767042
40GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.28557357
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.27740929
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.27390036
43MYC_18555785_ChIP-Seq_MESCs_Mouse1.26189661
44EST1_17652178_ChIP-ChIP_JURKAT_Human1.26014958
45PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.25773393
46ERG_20517297_ChIP-Seq_VCAP_Human1.25164595
47IGF1R_20145208_ChIP-Seq_DFB_Human1.23308847
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23119611
49STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.22359461
50CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.20171298
51PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.19618459
52NANOG_20526341_ChIP-Seq_ESCs_Human1.19044016
53ER_23166858_ChIP-Seq_MCF-7_Human1.16407015
54TAF2_19829295_ChIP-Seq_ESCs_Human1.15860953
55AR_20517297_ChIP-Seq_VCAP_Human1.14833591
56FOXP3_21729870_ChIP-Seq_TREG_Human1.14209892
57ELK1_19687146_ChIP-ChIP_HELA_Human1.13444472
58FOXH1_21741376_ChIP-Seq_EPCs_Human1.12685369
59UTX_26944678_Chip-Seq_JUKART_Human1.12284148
60PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.10505222
61MYB_26560356_Chip-Seq_TH1_Human1.09625217
62FOXA1_25329375_ChIP-Seq_VCAP_Human1.07570243
63FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07570243
64P300_27268052_Chip-Seq_Bcells_Human1.07258881
65SPI1_23547873_ChIP-Seq_NB4_Human1.04417373
66NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.04156661
67EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.03300747
68GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.02169475
69BCL6_27268052_Chip-Seq_Bcells_Human1.01952552
70RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.01789867
71ELK1_22589737_ChIP-Seq_MCF10A_Human1.01501696
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01300293
73CBP_20019798_ChIP-Seq_JUKART_Human1.01300293
74ELF1_20517297_ChIP-Seq_JURKAT_Human0.99848749
75EWS_26573619_Chip-Seq_HEK293_Human0.97744024
76ZFP57_27257070_Chip-Seq_ESCs_Mouse0.97663599
77NFE2_27457419_Chip-Seq_LIVER_Mouse0.96705155
78LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.96583309
79VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.96046261
80FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95431609
81BMI1_23680149_ChIP-Seq_NPCS_Mouse0.94707352
82GATA3_26560356_Chip-Seq_TH1_Human0.94601832
83EGR1_23403033_ChIP-Seq_LIVER_Mouse0.94249539
84YY1_22570637_ChIP-Seq_MALME-3M_Human0.93924534
85HOXB4_20404135_ChIP-ChIP_EML_Mouse0.93791000
86PCGF2_27294783_Chip-Seq_ESCs_Mouse0.92518913
87SOX2_19829295_ChIP-Seq_ESCs_Human0.91903555
88NANOG_19829295_ChIP-Seq_ESCs_Human0.91903555
89TTF2_22483619_ChIP-Seq_HELA_Human0.91214226
90FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91172573
91PCGF2_27294783_Chip-Seq_NPCs_Mouse0.90664888
92NCOR_22424771_ChIP-Seq_293T_Human0.90299694
93GATA3_21878914_ChIP-Seq_MCF-7_Human0.89722467
94AUTS2_25519132_ChIP-Seq_293T-REX_Human0.89715721
95HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.87655578
96CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87517544
97SRF_21415370_ChIP-Seq_HL-1_Mouse0.87277785
98FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.86900155
99PHF8_20622853_ChIP-Seq_HELA_Human0.86808979
100GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.86605373

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.16499331
2MP0003763_abnormal_thymus_physiology3.08419226
3MP0001835_abnormal_antigen_presentation3.08194589
4MP0009379_abnormal_foot_pigmentation2.93359473
5MP0009785_altered_susceptibility_to2.76779802
6MP0003806_abnormal_nucleotide_metabolis2.63570143
7MP0004084_abnormal_cardiac_muscle2.52651837
8MP0002837_dystrophic_cardiac_calcinosis2.48623263
9MP0006054_spinal_hemorrhage2.47990820
10MP0001800_abnormal_humoral_immune2.44318248
11MP0002102_abnormal_ear_morphology2.38285523
12MP0004145_abnormal_muscle_electrophysio2.33967547
13MP0009333_abnormal_splenocyte_physiolog2.28028882
14MP0003011_delayed_dark_adaptation2.21972279
15MP0005000_abnormal_immune_tolerance2.20358662
16MP0003866_abnormal_defecation2.17029316
17MP0002148_abnormal_hypersensitivity_rea2.12071633
18MP0010155_abnormal_intestine_physiology2.07851672
19MP0001790_abnormal_immune_system2.07356079
20MP0005387_immune_system_phenotype2.07356079
21MP0002723_abnormal_immune_serum2.07117829
22MP0005645_abnormal_hypothalamus_physiol2.01314007
23MP0002420_abnormal_adaptive_immunity1.87121959
24MP0001819_abnormal_immune_cell1.87118103
25MP0002653_abnormal_ependyma_morphology1.83971724
26MP0006292_abnormal_olfactory_placode1.80452823
27MP0005025_abnormal_response_to1.79282266
28MP0003195_calcinosis1.78477051
29MP0002452_abnormal_antigen_presenting1.76697631
30MP0005377_hearing/vestibular/ear_phenot1.72629786
31MP0003878_abnormal_ear_physiology1.72629786
32MP0002736_abnormal_nociception_after1.59820866
33MP0003724_increased_susceptibility_to1.56571123
34MP0002277_abnormal_respiratory_mucosa1.56091050
35MP0001968_abnormal_touch/_nociception1.54514199
36MP0008872_abnormal_physiological_respon1.50099689
37MP0001873_stomach_inflammation1.46965858
38MP0006082_CNS_inflammation1.44416694
39MP0001348_abnormal_lacrimal_gland1.43666352
40MP0005646_abnormal_pituitary_gland1.42842640
41MP0000716_abnormal_immune_system1.42311298
42MP0003880_abnormal_central_pattern1.40669408
43MP0005623_abnormal_meninges_morphology1.40286321
44MP0000685_abnormal_immune_system1.40027958
45MP0002398_abnormal_bone_marrow1.38902686
46MP0006072_abnormal_retinal_apoptosis1.38700603
47MP0009697_abnormal_copulation1.34256206
48MP0004036_abnormal_muscle_relaxation1.32753870
49MP0001986_abnormal_taste_sensitivity1.32318400
50MP0001845_abnormal_inflammatory_respons1.26594943
51MP0002876_abnormal_thyroid_physiology1.24792847
52MP0002419_abnormal_innate_immunity1.24538054
53MP0002722_abnormal_immune_system1.24155066
54MP0000703_abnormal_thymus_morphology1.21666886
55MP0002138_abnormal_hepatobiliary_system1.20632553
56MP0001905_abnormal_dopamine_level1.18875322
57MP0008875_abnormal_xenobiotic_pharmacok1.15346452
58MP0009765_abnormal_xenobiotic_induced1.13225087
59MP0000689_abnormal_spleen_morphology1.12361743
60MP0002405_respiratory_system_inflammati1.09974386
61MP0004215_abnormal_myocardial_fiber1.08909289
62MP0002429_abnormal_blood_cell1.08847325
63MP0002166_altered_tumor_susceptibility1.07961702
64MP0005410_abnormal_fertilization1.04955849
65MP0005551_abnormal_eye_electrophysiolog1.04850337
66MP0005253_abnormal_eye_physiology1.01243841
67MP0003279_aneurysm1.00473704
68MP0005084_abnormal_gallbladder_morpholo1.00380881
69MP0003436_decreased_susceptibility_to0.99385186
70MP0001919_abnormal_reproductive_system0.98057238
71MP0000372_irregular_coat_pigmentation0.97591971
72MP0005075_abnormal_melanosome_morpholog0.97448584
73MP0003693_abnormal_embryo_hatching0.94145887
74MP0005647_abnormal_sex_gland0.94017300
75MP0004130_abnormal_muscle_cell0.90593002
76MP0003567_abnormal_fetal_cardiomyocyte0.90068960
77MP0002693_abnormal_pancreas_physiology0.89836387
78MP0001502_abnormal_circadian_rhythm0.89473187
79MP0006276_abnormal_autonomic_nervous0.88556461
80MP0001501_abnormal_sleep_pattern0.86810319
81MP0008469_abnormal_protein_level0.85622233
82MP0009764_decreased_sensitivity_to0.84241186
83MP0003786_premature_aging0.82513366
84MP0004484_altered_response_of0.77149559
85MP0005389_reproductive_system_phenotype0.75678492
86MP0002006_tumorigenesis0.73646725
87MP0002733_abnormal_thermal_nociception0.69845259
88MP0002234_abnormal_pharynx_morphology0.68281959
89MP0002095_abnormal_skin_pigmentation0.67882986
90MP0005310_abnormal_salivary_gland0.66651923
91MP0001486_abnormal_startle_reflex0.64286830
92MP0001765_abnormal_ion_homeostasis0.64050720
93MP0009763_increased_sensitivity_to0.62203951
94MP0002933_joint_inflammation0.62050963
95MP0001764_abnormal_homeostasis0.61226284
96MP0003186_abnormal_redox_activity0.60059592
97MP0005165_increased_susceptibility_to0.59990231
98MP0000604_amyloidosis0.58914533
99MP0003633_abnormal_nervous_system0.58621317
100MP0005636_abnormal_mineral_homeostasis0.58526683

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)4.81032387
2IgG deficiency (HP:0004315)4.59621303
3Chronic hepatic failure (HP:0100626)4.38493212
4Autoimmune hemolytic anemia (HP:0001890)4.21618183
5Autoimmune thrombocytopenia (HP:0001973)4.06059643
6Acute necrotizing encephalopathy (HP:0006965)4.05927960
7Testicular atrophy (HP:0000029)3.90190677
8Abnormal mitochondria in muscle tissue (HP:0008316)3.67131116
9Mitochondrial inheritance (HP:0001427)3.50913938
10Stomatitis (HP:0010280)3.50367446
113-Methylglutaconic aciduria (HP:0003535)3.49765080
12Progressive macrocephaly (HP:0004481)3.43538694
13Abnormal number of erythroid precursors (HP:0012131)3.40874353
14Increased hepatocellular lipid droplets (HP:0006565)3.36886787
15Abnormality of B cell number (HP:0010975)3.31500650
16Abnormality of T cells (HP:0002843)3.28802205
17Acute encephalopathy (HP:0006846)3.21545552
18B lymphocytopenia (HP:0010976)3.21005915
19Abnormality of the prostate (HP:0008775)3.15850079
20Abnormality of cells of the erythroid lineage (HP:0012130)3.15034704
21Increased intramyocellular lipid droplets (HP:0012240)3.14422506
22Absent rod-and cone-mediated responses on ERG (HP:0007688)3.11469006
23Prostate neoplasm (HP:0100787)3.11231516
24Lipid accumulation in hepatocytes (HP:0006561)3.04951144
25Aplastic anemia (HP:0001915)3.02650146
26Increased IgM level (HP:0003496)2.95494479
27Dyschromatopsia (HP:0007641)2.95134763
28T lymphocytopenia (HP:0005403)2.92864115
29Abnormality of T cell physiology (HP:0011840)2.92653231
30Increased CSF lactate (HP:0002490)2.91816269
31Increased neuronal autofluorescent lipopigment (HP:0002074)2.86832423
32Abnormality of T cell number (HP:0011839)2.75702712
33Hypoproteinemia (HP:0003075)2.74108124
34Congenital stationary night blindness (HP:0007642)2.67682215
35Severe combined immunodeficiency (HP:0004430)2.64672446
36Increased muscle lipid content (HP:0009058)2.64414255
37Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.64368807
38Decreased central vision (HP:0007663)2.61858867
39Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.60772635
40Optic disc pallor (HP:0000543)2.57474107
41Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.53993578
42Decreased activity of mitochondrial respiratory chain (HP:0008972)2.53993578
43Macrocytic anemia (HP:0001972)2.51877080
44Abnormal rod and cone electroretinograms (HP:0008323)2.50338615
45Pancreatic cysts (HP:0001737)2.46535937
46True hermaphroditism (HP:0010459)2.46171712
47Panhypogammaglobulinemia (HP:0003139)2.44470955
48Myositis (HP:0100614)2.43326438
49Cerebral edema (HP:0002181)2.41979683
50Molar tooth sign on MRI (HP:0002419)2.40254095
51Abnormality of midbrain morphology (HP:0002418)2.40254095
52Renal Fanconi syndrome (HP:0001994)2.38604992
53Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.36211180
54Exertional dyspnea (HP:0002875)2.33628029
55Visual hallucinations (HP:0002367)2.33529221
56Lymphopenia (HP:0001888)2.32446017
57Thyroiditis (HP:0100646)2.29615476
58Hepatocellular necrosis (HP:0001404)2.28857372
59Central scotoma (HP:0000603)2.28507968
60Pancreatic fibrosis (HP:0100732)2.25800408
61Increased cerebral lipofuscin (HP:0011813)2.24583400
62Chronic otitis media (HP:0000389)2.24033223
63Encephalitis (HP:0002383)2.20469850
64IgM deficiency (HP:0002850)2.19878441
65Chronic diarrhea (HP:0002028)2.17699725
66Renal cortical cysts (HP:0000803)2.14731903
67Lymphoma (HP:0002665)2.13828577
68Increased serum lactate (HP:0002151)2.13174138
69Attenuation of retinal blood vessels (HP:0007843)2.11049163
70Cerebral palsy (HP:0100021)2.07011709
71Abnormality of cells of the lymphoid lineage (HP:0012140)2.05367819
72Leukodystrophy (HP:0002415)2.04727590
73Abnormal hemoglobin (HP:0011902)2.04409068
74Pallor (HP:0000980)2.04317616
75Agammaglobulinemia (HP:0004432)2.03659947
76Combined immunodeficiency (HP:0005387)1.99834633
77Progressive inability to walk (HP:0002505)1.99641642
78Multiple enchondromatosis (HP:0005701)1.98326138
79Pustule (HP:0200039)1.96505527
80Poikiloderma (HP:0001029)1.95783852
81Constricted visual fields (HP:0001133)1.94147312
82Vasculitis (HP:0002633)1.93131869
83Abolished electroretinogram (ERG) (HP:0000550)1.92272271
84Abnormality of eosinophils (HP:0001879)1.91023777
85Parakeratosis (HP:0001036)1.90476960
86Recurrent viral infections (HP:0004429)1.85149914
87Long nose (HP:0003189)1.84456991
88Hepatic necrosis (HP:0002605)1.80424217
89Pancytopenia (HP:0001876)1.79329410
90Exercise intolerance (HP:0003546)1.79191173
91Hypergonadotropic hypogonadism (HP:0000815)1.79119083
92Premature ovarian failure (HP:0008209)1.77561231
93Abnormality of male internal genitalia (HP:0000022)1.76581442
94Recurrent cutaneous fungal infections (HP:0011370)1.75120738
95Chronic mucocutaneous candidiasis (HP:0002728)1.75120738
96Eosinophilia (HP:0001880)1.74912991
97Bile duct proliferation (HP:0001408)1.73775585
98Abnormal biliary tract physiology (HP:0012439)1.73775585
99Abnormality of the fovea (HP:0000493)1.73287647
100Cleft eyelid (HP:0000625)1.71664498

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PASK5.87038255
2TXK5.56589895
3TESK24.28770194
4KDR3.53461075
5MAP4K13.02678184
6ZAK2.94204445
7CAMKK12.75170468
8ADRBK22.26866787
9MAP4K22.13448620
10MUSK2.05655768
11ITK1.97980330
12SCYL21.79580083
13WNK41.75274032
14TEC1.73284576
15MAP3K131.67192546
16TLK11.63404620
17FES1.61277166
18CAMKK21.54261644
19SYK1.50998038
20VRK21.44550159
21BRSK21.43098513
22TRIM281.39071765
23MAP3K121.38146209
24EIF2AK31.34989900
25IKBKB1.34003224
26ZAP701.29157411
27DAPK21.28640259
28NEK11.25921741
29PIK3CG1.25781442
30BTK1.25624841
31PINK11.22539470
32NUAK11.22336049
33GRK11.21950798
34JAK31.21851274
35LCK1.19519759
36LRRK21.19156529
37TYRO31.13881963
38VRK11.13713647
39DYRK21.11167052
40MYLK1.05613020
41BUB11.04788910
42TESK10.99043043
43DAPK10.95226242
44PRKCQ0.93130972
45LYN0.93038340
46TBK10.89960300
47NME20.86503148
48LIMK10.86113288
49PRKG20.84956790
50MAP3K140.83194628
51BCKDK0.80121034
52MAP2K60.75636773
53TIE10.72377441
54IKBKE0.69678062
55CSK0.67910620
56RPS6KA50.67641015
57RIPK40.63737111
58GRK60.63439990
59PLK40.62731149
60FRK0.62230700
61MAP3K110.59736555
62ADRBK10.57202357
63RPS6KB20.54740909
64CSF1R0.54180000
65DAPK30.53852992
66INSRR0.53668915
67NEK20.52012063
68KIT0.51477994
69GRK70.50635256
70BMPR1B0.50078200
71IGF1R0.48871750
72BRSK10.45548952
73NME10.41961350
74TAOK30.40906747
75ILK0.39606407
76HCK0.39437501
77OBSCN0.38922144
78CLK10.38509669
79PIM10.37235456
80WNK30.36605395
81PRKCD0.35654049
82FYN0.31839034
83PRKCA0.30312639
84FLT30.29024384
85MAPK130.28754748
86SIK20.28138810
87CHEK20.27984223
88ABL10.25477840
89MATK0.24361627
90CSNK2A10.24038529
91ACVR1B0.23805614
92STK160.23306934
93GRK50.23149341
94PRKACA0.22959512
95PBK0.22321870
96CSNK2A20.21420575
97PAK60.20837354
98CHUK0.19629519
99MAPKAPK50.19458944
100PHKG20.18346131

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.50317727
2Primary immunodeficiency_Homo sapiens_hsa053404.15827372
3Proteasome_Homo sapiens_hsa030503.40305807
4Allograft rejection_Homo sapiens_hsa053303.34412368
5Autoimmune thyroid disease_Homo sapiens_hsa053203.04359432
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.93257507
7Graft-versus-host disease_Homo sapiens_hsa053322.72258855
8Asthma_Homo sapiens_hsa053102.66700948
9Oxidative phosphorylation_Homo sapiens_hsa001902.63255177
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.61787473
11Type I diabetes mellitus_Homo sapiens_hsa049402.41469100
12Antigen processing and presentation_Homo sapiens_hsa046122.30045563
13Parkinsons disease_Homo sapiens_hsa050122.30044349
14RNA polymerase_Homo sapiens_hsa030202.15129170
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.85869294
16Protein export_Homo sapiens_hsa030601.78101603
17Rheumatoid arthritis_Homo sapiens_hsa053231.76585279
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.75218810
19T cell receptor signaling pathway_Homo sapiens_hsa046601.69882965
20Hematopoietic cell lineage_Homo sapiens_hsa046401.61079759
21Linoleic acid metabolism_Homo sapiens_hsa005911.52451016
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.44313566
23SNARE interactions in vesicular transport_Homo sapiens_hsa041301.40876977
24Alzheimers disease_Homo sapiens_hsa050101.35689104
25Huntingtons disease_Homo sapiens_hsa050161.29745527
26Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.28300889
27Phototransduction_Homo sapiens_hsa047441.26824153
28Cardiac muscle contraction_Homo sapiens_hsa042601.26677785
29Systemic lupus erythematosus_Homo sapiens_hsa053221.24806495
30Measles_Homo sapiens_hsa051621.24238312
31Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.22012594
32Viral myocarditis_Homo sapiens_hsa054161.20622372
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.18650866
34NF-kappa B signaling pathway_Homo sapiens_hsa040641.14624249
35Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.10190620
36Regulation of autophagy_Homo sapiens_hsa041401.08871099
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.05171062
38RNA degradation_Homo sapiens_hsa030181.04515567
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.02060209
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.96972367
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.95991516
42Pyrimidine metabolism_Homo sapiens_hsa002400.90965560
43Ether lipid metabolism_Homo sapiens_hsa005650.86926470
44Staphylococcus aureus infection_Homo sapiens_hsa051500.86674964
45Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.80206594
46Homologous recombination_Homo sapiens_hsa034400.79196587
47Purine metabolism_Homo sapiens_hsa002300.78183668
48Olfactory transduction_Homo sapiens_hsa047400.75662113
49Fanconi anemia pathway_Homo sapiens_hsa034600.73860380
50Caffeine metabolism_Homo sapiens_hsa002320.72286533
51NOD-like receptor signaling pathway_Homo sapiens_hsa046210.66263771
52Salivary secretion_Homo sapiens_hsa049700.64368621
53Taste transduction_Homo sapiens_hsa047420.63692179
54Nitrogen metabolism_Homo sapiens_hsa009100.58177926
55Retinol metabolism_Homo sapiens_hsa008300.57913168
56Malaria_Homo sapiens_hsa051440.57776371
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57756484
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55724513
59Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.54508398
60Shigellosis_Homo sapiens_hsa051310.52926276
61Drug metabolism - other enzymes_Homo sapiens_hsa009830.52646456
62Arachidonic acid metabolism_Homo sapiens_hsa005900.52605143
63Peroxisome_Homo sapiens_hsa041460.48969086
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47172544
65ABC transporters_Homo sapiens_hsa020100.46975554
66Tryptophan metabolism_Homo sapiens_hsa003800.46554918
67Toll-like receptor signaling pathway_Homo sapiens_hsa046200.43287701
68Salmonella infection_Homo sapiens_hsa051320.41173020
69Chemokine signaling pathway_Homo sapiens_hsa040620.40045470
70Spliceosome_Homo sapiens_hsa030400.39747908
71Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39002768
72Herpes simplex infection_Homo sapiens_hsa051680.38882392
73Chemical carcinogenesis_Homo sapiens_hsa052040.38881449
74Leishmaniasis_Homo sapiens_hsa051400.38638064
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.36021422
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34645430
77African trypanosomiasis_Homo sapiens_hsa051430.34102978
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33096674
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32780441
80Propanoate metabolism_Homo sapiens_hsa006400.32266213
81Epstein-Barr virus infection_Homo sapiens_hsa051690.31872447
82Mismatch repair_Homo sapiens_hsa034300.31522220
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.31247703
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.31162911
85One carbon pool by folate_Homo sapiens_hsa006700.30580949
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30335292
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29525900
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.28761615
89Nucleotide excision repair_Homo sapiens_hsa034200.28319771
90Serotonergic synapse_Homo sapiens_hsa047260.27941656
91Metabolic pathways_Homo sapiens_hsa011000.27797806
92Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.27098290
93Butanoate metabolism_Homo sapiens_hsa006500.26646042
94Legionellosis_Homo sapiens_hsa051340.23673461
95p53 signaling pathway_Homo sapiens_hsa041150.23272530
96Morphine addiction_Homo sapiens_hsa050320.22623555
97RNA transport_Homo sapiens_hsa030130.22364671
98Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.21881235
99TNF signaling pathway_Homo sapiens_hsa046680.21853173
100Collecting duct acid secretion_Homo sapiens_hsa049660.20952326

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