ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.67840815
2	xenobiotic catabolic process (GO:0042178)	4.60078460
3	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.49774959
4	response to pheromone (GO:0019236)	4.41237066
5	chaperone mediated protein folding requiring cofactor (GO:0051085)	4.38020531
6	proteasome assembly (GO:0043248)	4.26629274
7	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.15280875
8	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.15280875
9	NADH dehydrogenase complex assembly (GO:0010257)	4.15280875
10	ATP synthesis coupled proton transport (GO:0015986)	4.10292641
11	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.10292641
12	GTP biosynthetic process (GO:0006183)	4.07887227
13	positive regulation of prostaglandin secretion (GO:0032308)	3.99427208
14	protein complex biogenesis (GO:0070271)	3.93385713
15	phenylpropanoid metabolic process (GO:0009698)	3.87269134
16	regulation of immunoglobulin secretion (GO:0051023)	3.85066614
17	water-soluble vitamin biosynthetic process (GO:0042364)	3.79522937
18	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.77209280
19	termination of RNA polymerase III transcription (GO:0006386)	3.77209280
20	chaperone-mediated protein transport (GO:0072321)	3.68434818
21	mitochondrial respiratory chain complex assembly (GO:0033108)	3.64465890
22	UTP biosynthetic process (GO:0006228)	3.58990295
23	UTP metabolic process (GO:0046051)	3.58309825
24	protein localization to cilium (GO:0061512)	3.46664236
25	ribosomal large subunit biogenesis (GO:0042273)	3.44480884
26	DNA deamination (GO:0045006)	3.37619052
27	cell wall macromolecule catabolic process (GO:0016998)	3.34706228
28	preassembly of GPI anchor in ER membrane (GO:0016254)	3.34380888
29	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	3.31267095
30	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	3.29348346
31	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	3.29348346
32	isotype switching (GO:0045190)	3.29348346
33	piRNA metabolic process (GO:0034587)	3.25223453
34	protein refolding (GO:0042026)	3.23799793
35	prenylation (GO:0097354)	3.19737272
36	protein prenylation (GO:0018342)	3.19737272
37	regulation of prostaglandin secretion (GO:0032306)	3.16287627
38	DNA damage response, detection of DNA damage (GO:0042769)	3.15776357
39	termination of RNA polymerase I transcription (GO:0006363)	3.14636714
40	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.13600904
41	transcription elongation from RNA polymerase I promoter (GO:0006362)	3.06603812
42	CTP metabolic process (GO:0046036)	3.03834376
43	CTP biosynthetic process (GO:0006241)	3.03834376
44	regulation of meiosis I (GO:0060631)	3.02944925
45	2-deoxyribonucleotide biosynthetic process (GO:0009265)	3.01238873
46	deoxyribose phosphate biosynthetic process (GO:0046385)	3.01238873
47	magnesium ion transport (GO:0015693)	3.00974974
48	autophagic vacuole fusion (GO:0000046)	2.93231747
49	tryptophan metabolic process (GO:0006568)	2.91077361
50	protein deneddylation (GO:0000338)	2.88649302
51	cell wall macromolecule metabolic process (GO:0044036)	2.85522209
52	benzene-containing compound metabolic process (GO:0042537)	2.83636252
53	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.81647376
54	type B pancreatic cell development (GO:0003323)	2.80879336
55	mitochondrial calcium ion transport (GO:0006851)	2.79238095
56	pseudouridine synthesis (GO:0001522)	2.78386127
57	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	2.78256590
58	synapsis (GO:0007129)	2.76780287
59	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.76479642
60	negative regulation of acute inflammatory response (GO:0002674)	2.76374464
61	mannosylation (GO:0097502)	2.74700431
62	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.74300639
63	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.73578812
64	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.71401672
65	guanosine-containing compound biosynthetic process (GO:1901070)	2.70646263
66	plasma membrane fusion (GO:0045026)	2.68692801
67	aggressive behavior (GO:0002118)	2.68221113
68	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.66585460
69	regulation of mitotic spindle checkpoint (GO:1903504)	2.66585460
70	pyrimidine ribonucleoside biosynthetic process (GO:0046132)	2.65399298
71	somite development (GO:0061053)	2.65317630
72	protein-cofactor linkage (GO:0018065)	2.63112736
73	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.62450023
74	GPI anchor metabolic process (GO:0006505)	2.62069222
75	regulation of female receptivity (GO:0045924)	2.61445681
76	DNA methylation involved in gamete generation (GO:0043046)	2.60584824
77	electron transport chain (GO:0022900)	2.58053938
78	toxin metabolic process (GO:0009404)	2.56960215
79	respiratory electron transport chain (GO:0022904)	2.56709400
80	regulation of mitochondrial translation (GO:0070129)	2.56221961
81	pyrimidine nucleotide biosynthetic process (GO:0006221)	2.55897218
82	female mating behavior (GO:0060180)	2.55560761
83	intraciliary transport (GO:0042073)	2.55404175
84	maturation of 5.8S rRNA (GO:0000460)	2.55222005
85	transcription initiation from RNA polymerase I promoter (GO:0006361)	2.54311401
86	cullin deneddylation (GO:0010388)	2.54136158
87	transcription from RNA polymerase I promoter (GO:0006360)	2.52131899
88	positive regulation of mast cell degranulation (GO:0043306)	2.51994283
89	positive regulation of mast cell activation involved in immune response (GO:0033008)	2.51994283
90	parental behavior (GO:0060746)	2.51964922
91	spermatid nucleus differentiation (GO:0007289)	2.49102944
92	regulation of penile erection (GO:0060405)	2.48461868
93	pyrimidine ribonucleotide biosynthetic process (GO:0009220)	2.47426909
94	nucleoside diphosphate phosphorylation (GO:0006165)	2.47305256
95	oxidative phosphorylation (GO:0006119)	2.46400510
96	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.46111667
97	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.46111667
98	positive regulation of icosanoid secretion (GO:0032305)	2.45861918
99	protein neddylation (GO:0045116)	2.45528075
100	nucleotide transmembrane transport (GO:1901679)	2.44449953

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.38169975
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.76523471
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.65489565
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.22689202
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.02151016
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.76692642
7	VDR_22108803_ChIP-Seq_LS180_Human	2.68304735
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.60707894
9	EWS_26573619_Chip-Seq_HEK293_Human	2.50556932
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.47929630
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.39933344
12	ELK1_19687146_ChIP-ChIP_HELA_Human	2.37636473
13	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.34026414
14	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.18240541
15	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.16959678
16	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.14697546
17	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.10323502
18	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.04831542
19	IGF1R_20145208_ChIP-Seq_DFB_Human	2.04441339
20	VDR_23849224_ChIP-Seq_CD4+_Human	1.99706149
21	GBX2_23144817_ChIP-Seq_PC3_Human	1.87559973
22	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.85964390
23	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.85687846
24	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.84214935
25	MYC_18940864_ChIP-ChIP_HL60_Human	1.78822765
26	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.76164731
27	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.75122299
28	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.71963655
29	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.70221290
30	TP53_22573176_ChIP-Seq_HFKS_Human	1.68444644
31	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.67474431
32	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.66192165
33	P300_19829295_ChIP-Seq_ESCs_Human	1.63338762
34	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.60188310
35	FOXP3_21729870_ChIP-Seq_TREG_Human	1.60076796
36	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.59367484
37	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.56513566
38	IRF1_19129219_ChIP-ChIP_H3396_Human	1.52620200
39	ER_23166858_ChIP-Seq_MCF-7_Human	1.49452433
40	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.49344050
41	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.40968593
42	SOX2_19829295_ChIP-Seq_ESCs_Human	1.40322656
43	NANOG_19829295_ChIP-Seq_ESCs_Human	1.40322656
44	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.40295894
45	HTT_18923047_ChIP-ChIP_STHdh_Human	1.38859895
46	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.37026800
47	AR_20517297_ChIP-Seq_VCAP_Human	1.35853032
48	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.33952665
49	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.33220574
50	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.30689622
51	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.28971469
52	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.26398809
53	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.22666475
54	FUS_26573619_Chip-Seq_HEK293_Human	1.22414559
55	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.22253657
56	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.22180969
57	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.21919385
58	ERG_20517297_ChIP-Seq_VCAP_Human	1.20989844
59	CDX2_22108803_ChIP-Seq_LS180_Human	1.20974125
60	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.20873497
61	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.20712744
62	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.20561986
63	CBP_20019798_ChIP-Seq_JUKART_Human	1.20561986
64	AR_25329375_ChIP-Seq_VCAP_Human	1.17849879
65	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.16753582
66	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.16726193
67	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.16598712
68	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.13926244
69	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.12648570
70	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.11886757
71	RNF2_27304074_Chip-Seq_NSC_Mouse	1.11403974
72	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.11384329
73	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.11384329
74	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.10637686
75	EZH2_22144423_ChIP-Seq_EOC_Human	1.08657412
76	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.08094668
77	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.06348015
78	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.05267649
79	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.03558932
80	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.02473450
81	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.01958034
82	TCF4_23295773_ChIP-Seq_U87_Human	1.01320784
83	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.00376657
84	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.99585140
85	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.99281625
86	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.98770341
87	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.98657554
88	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.97616304
89	RBPJ_21746931_ChIP-Seq_IB4_Human	0.97299277
90	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.97206040
91	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.96669791
92	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.96669791
93	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.96519590
94	TCF4_22108803_ChIP-Seq_LS180_Human	0.96169219
95	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.95690838
96	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.95007254
97	BCAT_22108803_ChIP-Seq_LS180_Human	0.94341798
98	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.94303897
99	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.94126389
100	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.93627685

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008875_abnormal_xenobiotic_pharmacok	4.68431745
2	MP0003787_abnormal_imprinting	3.58558841
3	MP0001835_abnormal_antigen_presentation	3.44694661
4	MP0008877_abnormal_DNA_methylation	3.21297979
5	MP0003718_maternal_effect	3.10639951
6	MP0006072_abnormal_retinal_apoptosis	3.01172372
7	MP0002277_abnormal_respiratory_mucosa	2.60125194
8	MP0002102_abnormal_ear_morphology	2.55871692
9	MP0001984_abnormal_olfaction	2.41096670
10	MP0005646_abnormal_pituitary_gland	2.35795597
11	MP0008872_abnormal_physiological_respon	2.30299653
12	MP0006292_abnormal_olfactory_placode	2.26349522
13	MP0002160_abnormal_reproductive_system	2.15326526
14	MP0003806_abnormal_nucleotide_metabolis	2.06875369
15	MP0004885_abnormal_endolymph	1.98594742
16	MP0000631_abnormal_neuroendocrine_gland	1.96711906
17	MP0004133_heterotaxia	1.93194795
18	MP0002272_abnormal_nervous_system	1.68366345
19	MP0005551_abnormal_eye_electrophysiolog	1.63118675
20	MP0005084_abnormal_gallbladder_morpholo	1.62480516
21	MP0005389_reproductive_system_phenotype	1.61969500
22	MP0000372_irregular_coat_pigmentation	1.61474684
23	MP0005671_abnormal_response_to	1.60888002
24	MP0005075_abnormal_melanosome_morpholog	1.55151631
25	MP0005410_abnormal_fertilization	1.50086655
26	MP0001986_abnormal_taste_sensitivity	1.49046069
27	MP0001764_abnormal_homeostasis	1.47068991
28	MP0003121_genomic_imprinting	1.40333046
29	MP0002653_abnormal_ependyma_morphology	1.38142896
30	MP0008789_abnormal_olfactory_epithelium	1.37801799
31	MP0002138_abnormal_hepatobiliary_system	1.35066713
32	MP0008775_abnormal_heart_ventricle	1.31187058
33	MP0002938_white_spotting	1.28259744
34	MP0006036_abnormal_mitochondrial_physio	1.26839216
35	MP0002234_abnormal_pharynx_morphology	1.23790071
36	MP0005187_abnormal_penis_morphology	1.22945403
37	MP0000647_abnormal_sebaceous_gland	1.21820294
38	MP0001968_abnormal_touch/_nociception	1.20523394
39	MP0001529_abnormal_vocalization	1.17442750
40	MP0001756_abnormal_urination	1.16614284
41	MP0001873_stomach_inflammation	1.16184525
42	MP0005253_abnormal_eye_physiology	1.10641437
43	MP0001929_abnormal_gametogenesis	1.09950638
44	MP0003195_calcinosis	1.08893706
45	MP0009697_abnormal_copulation	1.08609569
46	MP0005085_abnormal_gallbladder_physiolo	1.08515728
47	MP0003011_delayed_dark_adaptation	1.07734021
48	MP0004142_abnormal_muscle_tone	1.04951916
49	MP0003122_maternal_imprinting	1.04738653
50	MP0002693_abnormal_pancreas_physiology	1.01909013
51	MP0009745_abnormal_behavioral_response	1.00422077
52	MP0005167_abnormal_blood-brain_barrier	0.98980267
53	MP0002736_abnormal_nociception_after	0.98774378
54	MP0002233_abnormal_nose_morphology	0.98685780
55	MP0005171_absent_coat_pigmentation	0.98472913
56	MP0002876_abnormal_thyroid_physiology	0.96984467
57	MP0002751_abnormal_autonomic_nervous	0.96631400
58	MP0006082_CNS_inflammation	0.95991102
59	MP0005503_abnormal_tendon_morphology	0.95882923
60	MP0003186_abnormal_redox_activity	0.95660542
61	MP0004019_abnormal_vitamin_homeostasis	0.94886357
62	MP0000013_abnormal_adipose_tissue	0.92301617
63	MP0000427_abnormal_hair_cycle	0.91156006
64	MP0001963_abnormal_hearing_physiology	0.90578166
65	MP0004145_abnormal_muscle_electrophysio	0.90051960
66	MP0000026_abnormal_inner_ear	0.89978234
67	MP0005360_urolithiasis	0.89853997
68	MP0005377_hearing/vestibular/ear_phenot	0.89696347
69	MP0003878_abnormal_ear_physiology	0.89696347
70	MP0001299_abnormal_eye_distance/	0.89428917
71	MP0002163_abnormal_gland_morphology	0.88610927
72	MP0001944_abnormal_pancreas_morphology	0.86215028
73	MP0004134_abnormal_chest_morphology	0.82994181
74	MP0003868_abnormal_feces_composition	0.82257403
75	MP0002210_abnormal_sex_determination	0.81618137
76	MP0003638_abnormal_response/metabolism_	0.81610460
77	MP0004147_increased_porphyrin_level	0.81552387
78	MP0002734_abnormal_mechanical_nocicepti	0.81496634
79	MP0003698_abnormal_male_reproductive	0.81379938
80	MP0002837_dystrophic_cardiac_calcinosis	0.80698268
81	MP0008007_abnormal_cellular_replicative	0.78601948
82	MP0000653_abnormal_sex_gland	0.78284416
83	MP0000639_abnormal_adrenal_gland	0.78209358
84	MP0006276_abnormal_autonomic_nervous	0.78009528
85	MP0001293_anophthalmia	0.77183682
86	MP0002735_abnormal_chemical_nociception	0.72853435
87	MP0006035_abnormal_mitochondrial_morpho	0.72507428
88	MP0002229_neurodegeneration	0.72372133
89	MP0003938_abnormal_ear_development	0.71815114
90	MP0009046_muscle_twitch	0.70954940
91	MP0001145_abnormal_male_reproductive	0.69445233
92	MP0000470_abnormal_stomach_morphology	0.69108751
93	MP0004924_abnormal_behavior	0.68430018
94	MP0005386_behavior/neurological_phenoty	0.68430018
95	MP0005220_abnormal_exocrine_pancreas	0.68298160
96	MP0003786_premature_aging	0.64952962
97	MP0002572_abnormal_emotion/affect_behav	0.63592498
98	MP0000383_abnormal_hair_follicle	0.63433350
99	MP0000049_abnormal_middle_ear	0.63246388
100	MP0002184_abnormal_innervation	0.62488925

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Degeneration of the lateral corticospinal tracts (HP:0002314)	4.21506603
2	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	4.21506603
3	Cerebral palsy (HP:0100021)	4.17099132
4	Stomatitis (HP:0010280)	3.95375352
5	Acute necrotizing encephalopathy (HP:0006965)	3.76619733
6	Abnormality of the prostate (HP:0008775)	3.58057909
7	Absent/shortened dynein arms (HP:0200106)	3.53062437
8	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.53062437
9	Acute encephalopathy (HP:0006846)	3.30046668
10	Progressive macrocephaly (HP:0004481)	3.26812527
11	Hemoptysis (HP:0002105)	3.18240517
12	Abnormal mitochondria in muscle tissue (HP:0008316)	3.03861776
13	Median cleft lip (HP:0000161)	3.00946159
14	Abnormality of the nasal septum (HP:0000419)	2.99449295
15	Hypothermia (HP:0002045)	2.98092758
16	Obstructive lung disease (HP:0006536)	2.94491530
17	Chronic obstructive pulmonary disease (HP:0006510)	2.94491530
18	Medial flaring of the eyebrow (HP:0010747)	2.89224747
19	3-Methylglutaconic aciduria (HP:0003535)	2.82407100
20	Mesomelia (HP:0003027)	2.80682689
21	Abnormality of the corticospinal tract (HP:0002492)	2.80647969
22	Ureteral obstruction (HP:0006000)	2.63939043
23	Cerebral edema (HP:0002181)	2.59109667
24	Hypoproteinemia (HP:0003075)	2.58341800
25	Adrenal hypoplasia (HP:0000835)	2.55670774
26	Increased IgM level (HP:0003496)	2.51369176
27	Constricted visual fields (HP:0001133)	2.47643337
28	Colon cancer (HP:0003003)	2.43415549
29	Abnormality of the pleura (HP:0002103)	2.40323678
30	Mitochondrial inheritance (HP:0001427)	2.39549069
31	Congenital stationary night blindness (HP:0007642)	2.38008968
32	Increased CSF lactate (HP:0002490)	2.36801926
33	Pancreatic cysts (HP:0001737)	2.35424350
34	Ureteral stenosis (HP:0000071)	2.35121648
35	Central scotoma (HP:0000603)	2.34683465
36	Chin dimple (HP:0010751)	2.32432345
37	Dyschromatopsia (HP:0007641)	2.31023177
38	Abnormal rod and cone electroretinograms (HP:0008323)	2.29394586
39	Large for gestational age (HP:0001520)	2.28829185
40	Congenital, generalized hypertrichosis (HP:0004540)	2.27111486
41	Septo-optic dysplasia (HP:0100842)	2.26496215
42	Congenital primary aphakia (HP:0007707)	2.25771452
43	Growth hormone deficiency (HP:0000824)	2.24954748
44	Multiple enchondromatosis (HP:0005701)	2.22706189
45	Neoplasm of the colon (HP:0100273)	2.21852798
46	Insulin-resistant diabetes mellitus (HP:0000831)	2.21297459
47	Abnormal ciliary motility (HP:0012262)	2.18911299
48	Gait imbalance (HP:0002141)	2.15632308
49	Nephrogenic diabetes insipidus (HP:0009806)	2.12461924
50	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.10412137
51	Hypoplasia of the fovea (HP:0007750)	2.10412137
52	Type II lissencephaly (HP:0007260)	2.09424598
53	Supernumerary spleens (HP:0009799)	2.07174279
54	Hypoplasia of the pons (HP:0012110)	2.06833188
55	Abnormality of male internal genitalia (HP:0000022)	2.05533782
56	Aplasia/hypoplasia of the uterus (HP:0008684)	2.04632856
57	Short phalanx of the thumb (HP:0009660)	2.02911522
58	Aplastic anemia (HP:0001915)	2.01898652
59	Hyperinsulinemic hypoglycemia (HP:0000825)	2.01372604
60	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.98536301
61	Abnormality of alanine metabolism (HP:0010916)	1.98536301
62	Hyperalaninemia (HP:0003348)	1.98536301
63	Abnormal respiratory motile cilium physiology (HP:0012261)	1.97595479
64	Severe muscular hypotonia (HP:0006829)	1.97129821
65	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.96084394
66	Hyperglycemia (HP:0003074)	1.96060425
67	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.95375393
68	Neoplasm of the adrenal cortex (HP:0100641)	1.94939704
69	Abnormality of the pericardium (HP:0001697)	1.93416080
70	Abnormal biliary tract physiology (HP:0012439)	1.93311121
71	Bile duct proliferation (HP:0001408)	1.93311121
72	Nephronophthisis (HP:0000090)	1.91938780
73	Decreased central vision (HP:0007663)	1.90806334
74	Termporal pattern (HP:0011008)	1.89931033
75	Insidious onset (HP:0003587)	1.89931033
76	Abnormality of the vasculature of the conjunctiva (HP:0008054)	1.89666464
77	Abnormal number of erythroid precursors (HP:0012131)	1.89388198
78	Type 2 muscle fiber atrophy (HP:0003554)	1.89150849
79	Scotoma (HP:0000575)	1.88057395
80	Gastrointestinal infarctions (HP:0005244)	1.87267206
81	Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)	1.86027415
82	Depressed nasal tip (HP:0000437)	1.85954861
83	Optic disc pallor (HP:0000543)	1.85083393
84	Abnormality of the pons (HP:0007361)	1.83958989
85	True hermaphroditism (HP:0010459)	1.82438799
86	Hypomagnesemia (HP:0002917)	1.81620550
87	Abnormal sex determination (HP:0012244)	1.79157728
88	Sex reversal (HP:0012245)	1.79157728
89	Abnormality of the fovea (HP:0000493)	1.77426396
90	Abnormality of macular pigmentation (HP:0008002)	1.76990242
91	Bilateral microphthalmos (HP:0007633)	1.76731876
92	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.76574345
93	Impaired vibration sensation in the lower limbs (HP:0002166)	1.74624279
94	Abnormality of the middle phalanges of the toes (HP:0010183)	1.73660194
95	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	1.73372557
96	Short 1st metacarpal (HP:0010034)	1.73372557
97	IgA deficiency (HP:0002720)	1.73328621
98	Cerebellar dysplasia (HP:0007033)	1.72501823
99	Facial cleft (HP:0002006)	1.72208439
100	Arthropathy (HP:0003040)	1.70871365

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.50712400
2	NUAK1	3.35621679
3	TIE1	3.35085716
4	MAPKAPK5	3.04726689
5	VRK2	2.84783054
6	ADRBK2	2.83019184
7	FES	2.67505029
8	EIF2AK3	2.57503472
9	INSRR	2.54628320
10	BCKDK	2.38979859
11	NME1	2.27561985
12	STK16	2.15140395
13	MKNK2	2.11993927
14	TAF1	2.11458772
15	TAOK1	2.09936870
16	TAOK3	2.09629688
17	MAP4K2	2.04436918
18	BMPR1B	1.93638902
19	GRK1	1.86247259
20	PBK	1.81311766
21	MST4	1.73618865
22	WNK3	1.73502858
23	FER	1.63911961
24	CSNK1G3	1.59265420
25	TLK1	1.57543920
26	TNIK	1.55880605
27	PINK1	1.55050493
28	VRK1	1.49980060
29	CSNK1A1L	1.44010111
30	MKNK1	1.43661851
31	EPHA3	1.42885905
32	CSNK1G1	1.41828763
33	CSNK1G2	1.29470441
34	TSSK6	1.28228081
35	NLK	1.25879822
36	MYLK	1.13919020
37	PLK3	1.11637965
38	CDK19	1.07952529
39	DAPK3	1.04448982
40	STK39	1.00821579
41	DYRK2	0.95404665
42	ACVR1B	0.92644960
43	OXSR1	0.91840235
44	WNK4	0.90216036
45	IKBKB	0.88289891
46	MAP3K12	0.86270710
47	GRK5	0.85164904
48	PHKG1	0.84133605
49	PHKG2	0.84133605
50	PLK2	0.84098311
51	ZAK	0.81484015
52	CDK3	0.77674995
53	EIF2AK1	0.77409206
54	PRKCE	0.75593553
55	RPS6KA5	0.74273830
56	IRAK1	0.71165758
57	TEC	0.69929239
58	CSNK1A1	0.68780865
59	CDC7	0.68738911
60	DAPK1	0.65498043
61	TNK2	0.64599393
62	BMPR2	0.63314555
63	KIT	0.62691672
64	PRKG1	0.61732873
65	PLK4	0.60950975
66	PASK	0.54281913
67	STK11	0.51564971
68	KDR	0.50871481
69	ILK	0.50863458
70	MAP3K4	0.50140075
71	PIM1	0.48664174
72	CAMK1	0.48377271
73	ITK	0.48329863
74	DAPK2	0.48286919
75	PRKCG	0.47343382
76	TGFBR2	0.46662415
77	CDK8	0.45069545
78	TGFBR1	0.44254534
79	CAMK2A	0.42905620
80	IRAK3	0.41060602
81	ADRBK1	0.40545632
82	HIPK2	0.40095354
83	LATS1	0.39543205
84	CDK9	0.39271230
85	PRKCA	0.37956630
86	CSNK2A2	0.37598745
87	EIF2AK2	0.36652350
88	PRKACA	0.34664555
89	AURKA	0.34326949
90	CSNK1E	0.33759578
91	PLK1	0.33635607
92	TRIM28	0.33327534
93	MAP3K9	0.32511058
94	EPHA4	0.30752496
95	CSNK2A1	0.30434976
96	OBSCN	0.30137865
97	FGFR2	0.30030830
98	RPS6KB2	0.24937640
99	PRKCD	0.24100397
100	MAP2K6	0.20922373

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	5.40982183
2	Allograft rejection_Homo sapiens_hsa05330	4.29759863
3	Autoimmune thyroid disease_Homo sapiens_hsa05320	4.05208573
4	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.94257727
5	Protein export_Homo sapiens_hsa03060	3.07091854
6	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.92653668
7	Graft-versus-host disease_Homo sapiens_hsa05332	2.78709588
8	Type I diabetes mellitus_Homo sapiens_hsa04940	2.72812349
9	Oxidative phosphorylation_Homo sapiens_hsa00190	2.52877042
10	Proteasome_Homo sapiens_hsa03050	2.44223042
11	RNA polymerase_Homo sapiens_hsa03020	2.12950051
12	Rheumatoid arthritis_Homo sapiens_hsa05323	2.12471548
13	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.11804704
14	Antigen processing and presentation_Homo sapiens_hsa04612	1.95661462
15	Basal transcription factors_Homo sapiens_hsa03022	1.93402810
16	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.91632319
17	Parkinsons disease_Homo sapiens_hsa05012	1.81720069
18	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.79811510
19	Ribosome_Homo sapiens_hsa03010	1.79567703
20	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.57712053
21	Phototransduction_Homo sapiens_hsa04744	1.56165321
22	Collecting duct acid secretion_Homo sapiens_hsa04966	1.53738328
23	Homologous recombination_Homo sapiens_hsa03440	1.42331561
24	Viral myocarditis_Homo sapiens_hsa05416	1.31910167
25	Mismatch repair_Homo sapiens_hsa03430	1.31315624
26	Caffeine metabolism_Homo sapiens_hsa00232	1.16243327
27	Huntingtons disease_Homo sapiens_hsa05016	1.09982720
28	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.06741934
29	Alzheimers disease_Homo sapiens_hsa05010	1.05500476
30	Cardiac muscle contraction_Homo sapiens_hsa04260	1.04609585
31	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.03776680
32	RNA degradation_Homo sapiens_hsa03018	1.03432746
33	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.98014138
34	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.97917102
35	Sulfur metabolism_Homo sapiens_hsa00920	0.96344594
36	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.96082998
37	Linoleic acid metabolism_Homo sapiens_hsa00591	0.93042921
38	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.90837192
39	RNA transport_Homo sapiens_hsa03013	0.89160376
40	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.88103999
41	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.86657028
42	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.82838441
43	Leishmaniasis_Homo sapiens_hsa05140	0.80766918
44	Pyrimidine metabolism_Homo sapiens_hsa00240	0.80511828
45	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.79572509
46	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.79404223
47	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.77241407
48	Tryptophan metabolism_Homo sapiens_hsa00380	0.75592470
49	Spliceosome_Homo sapiens_hsa03040	0.75472163
50	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.73163076
51	Nicotine addiction_Homo sapiens_hsa05033	0.72969230
52	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.68569626
53	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.66458076
54	Chemical carcinogenesis_Homo sapiens_hsa05204	0.66439962
55	Primary immunodeficiency_Homo sapiens_hsa05340	0.62648567
56	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.62643368
57	Retinol metabolism_Homo sapiens_hsa00830	0.59391169
58	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.59185508
59	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.59033298
60	Non-homologous end-joining_Homo sapiens_hsa03450	0.57693554
61	Olfactory transduction_Homo sapiens_hsa04740	0.55680213
62	Phagosome_Homo sapiens_hsa04145	0.53553653
63	DNA replication_Homo sapiens_hsa03030	0.52592117
64	Peroxisome_Homo sapiens_hsa04146	0.51700028
65	Regulation of autophagy_Homo sapiens_hsa04140	0.51446719
66	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.50442320
67	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.49534344
68	Nucleotide excision repair_Homo sapiens_hsa03420	0.47924530
69	GABAergic synapse_Homo sapiens_hsa04727	0.47469988
70	Purine metabolism_Homo sapiens_hsa00230	0.46682802
71	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.45554578
72	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.45409482
73	Propanoate metabolism_Homo sapiens_hsa00640	0.42938501
74	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.41259644
75	Ether lipid metabolism_Homo sapiens_hsa00565	0.40841388
76	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.40594583
77	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.39808995
78	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.35761780
79	Fanconi anemia pathway_Homo sapiens_hsa03460	0.35681608
80	Taste transduction_Homo sapiens_hsa04742	0.35338157
81	Metabolic pathways_Homo sapiens_hsa01100	0.35152793
82	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.33920589
83	Pyruvate metabolism_Homo sapiens_hsa00620	0.33619381
84	Toxoplasmosis_Homo sapiens_hsa05145	0.31087658
85	Nitrogen metabolism_Homo sapiens_hsa00910	0.29810895
86	Mineral absorption_Homo sapiens_hsa04978	0.28389174
87	Herpes simplex infection_Homo sapiens_hsa05168	0.27519495
88	Base excision repair_Homo sapiens_hsa03410	0.26037338
89	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.25696366
90	Oocyte meiosis_Homo sapiens_hsa04114	0.25573262
91	Selenocompound metabolism_Homo sapiens_hsa00450	0.24794747
92	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.24658135
93	Glutathione metabolism_Homo sapiens_hsa00480	0.23964662
94	Serotonergic synapse_Homo sapiens_hsa04726	0.23589560
95	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.21843417
96	One carbon pool by folate_Homo sapiens_hsa00670	0.21544624
97	Histidine metabolism_Homo sapiens_hsa00340	0.21443583
98	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.20746208
99	Influenza A_Homo sapiens_hsa05164	0.17182794
100	Renin-angiotensin system_Homo sapiens_hsa04614	0.16899071

BTF3P13

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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