ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	9.41017693
2	cytidine metabolic process (GO:0046087)	8.66339015
3	cytidine catabolic process (GO:0006216)	8.66339015
4	cytidine deamination (GO:0009972)	8.66339015
5	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	8.54312811
6	pyrimidine ribonucleoside catabolic process (GO:0046133)	7.43325893
7	ribosomal small subunit assembly (GO:0000028)	4.97371139
8	regulation of immunoglobulin secretion (GO:0051023)	4.18483766
9	positive T cell selection (GO:0043368)	3.88087225
10	positive regulation of B cell differentiation (GO:0045579)	3.79008296
11	positive thymic T cell selection (GO:0045059)	3.77679267
12	regulation of chronic inflammatory response (GO:0002676)	3.72715284
13	regulation of regulatory T cell differentiation (GO:0045589)	3.72665469
14	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	3.72331078
15	pyrimidine nucleoside catabolic process (GO:0046135)	3.64546883
16	proteasome assembly (GO:0043248)	3.64147677
17	negative regulation by host of viral transcription (GO:0043922)	3.57549327
18	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.54049031
19	ATP synthesis coupled proton transport (GO:0015986)	3.54049031
20	positive regulation of lymphocyte migration (GO:2000403)	3.46207586
21	negative regulation of T cell apoptotic process (GO:0070233)	3.45244895
22	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	3.41107078
23	regulation of B cell differentiation (GO:0045577)	3.37007174
24	eosinophil chemotaxis (GO:0048245)	3.36004308
25	regulation of activation of Janus kinase activity (GO:0010533)	3.22072144
26	negative regulation of viral genome replication (GO:0045071)	3.21031748
27	positive regulation of calcium-mediated signaling (GO:0050850)	3.18250393
28	activated T cell proliferation (GO:0050798)	3.17072130
29	T cell migration (GO:0072678)	3.15529706
30	negative regulation of T-helper cell differentiation (GO:0045623)	3.14980775
31	negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)	3.14980775
32	water-soluble vitamin biosynthetic process (GO:0042364)	3.10524281
33	positive regulation of tolerance induction (GO:0002645)	3.08590316
34	eosinophil migration (GO:0072677)	3.07499092
35	positive regulation of T cell migration (GO:2000406)	3.07349488
36	regulation of lymphocyte chemotaxis (GO:1901623)	3.06676171
37	ribosomal large subunit biogenesis (GO:0042273)	2.99353501
38	cellular response to interleukin-15 (GO:0071350)	2.96547404
39	regulation of B cell receptor signaling pathway (GO:0050855)	2.92728591
40	negative regulation of lymphocyte apoptotic process (GO:0070229)	2.91134415
41	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.90740868
42	regulation of T cell tolerance induction (GO:0002664)	2.89475012
43	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.89057468
44	negative regulation of mast cell activation (GO:0033004)	2.86662878
45	T cell receptor signaling pathway (GO:0050852)	2.86191358
46	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.84628702
47	positive regulation of granulocyte differentiation (GO:0030854)	2.82981880
48	negative regulation of T cell differentiation (GO:0045581)	2.80313081
49	regulation of T cell chemotaxis (GO:0010819)	2.79953117
50	positive regulation of T cell chemotaxis (GO:0010820)	2.79953117
51	macrophage chemotaxis (GO:0048246)	2.77581446
52	viral transcription (GO:0019083)	2.76917528
53	regulation of T cell migration (GO:2000404)	2.74865296
54	negative T cell selection (GO:0043383)	2.74330508
55	mast cell degranulation (GO:0043303)	2.74091834
56	mast cell activation involved in immune response (GO:0002279)	2.74091834
57	regulation of triglyceride catabolic process (GO:0010896)	2.73718397
58	mast cell activation (GO:0045576)	2.72920951
59	negative regulation of alpha-beta T cell differentiation (GO:0046639)	2.72408099
60	immunoglobulin mediated immune response (GO:0016064)	2.71764941
61	positive regulation of T cell cytokine production (GO:0002726)	2.71236358
62	translational elongation (GO:0006414)	2.70195435
63	positive regulation of interleukin-4 production (GO:0032753)	2.69897709
64	Peyers patch development (GO:0048541)	2.68601407
65	mucosal-associated lymphoid tissue development (GO:0048537)	2.68601407
66	regulation of T cell receptor signaling pathway (GO:0050856)	2.67451248
67	T cell selection (GO:0045058)	2.64908988
68	thymic T cell selection (GO:0045061)	2.64859178
69	chaperone-mediated protein transport (GO:0072321)	2.63666790
70	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.63511952
71	positive regulation of monocyte chemotaxis (GO:0090026)	2.62988637
72	cytolysis (GO:0019835)	2.62605410
73	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	2.61337719
74	negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)	2.61315601
75	negative regulation of lymphocyte differentiation (GO:0045620)	2.59963568
76	negative regulation of calcium ion transport into cytosol (GO:0010523)	2.57529645
77	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.56340414
78	lymphocyte costimulation (GO:0031294)	2.56189284
79	antigen receptor-mediated signaling pathway (GO:0050851)	2.55906050
80	negative regulation of T cell differentiation in thymus (GO:0033085)	2.55574864
81	translational termination (GO:0006415)	2.51751761
82	B cell mediated immunity (GO:0019724)	2.51667650
83	regulation of lymphocyte migration (GO:2000401)	2.51112134
84	organic cation transport (GO:0015695)	2.50963016
85	regulation of calcium-mediated signaling (GO:0050848)	2.50623332
86	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.49626731
87	S-adenosylmethionine metabolic process (GO:0046500)	2.49393061
88	purine nucleotide salvage (GO:0032261)	2.47481847
89	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.45762709
90	positive regulation of DNA recombination (GO:0045911)	2.45590327
91	negative thymic T cell selection (GO:0045060)	2.45282267
92	T cell costimulation (GO:0031295)	2.45088811
93	regulation of alpha-beta T cell proliferation (GO:0046640)	2.44503081
94	sulfation (GO:0051923)	2.44486808
95	maturation of SSU-rRNA (GO:0030490)	2.44308192
96	positive regulation of immunoglobulin production (GO:0002639)	2.42791603
97	cotranslational protein targeting to membrane (GO:0006613)	2.40636472
98	pyrimidine ribonucleoside metabolic process (GO:0046131)	2.40517749
99	purine-containing compound salvage (GO:0043101)	2.39464570
100	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.36772249

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	6.96317814
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	5.50594407
3	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	3.78788948
4	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.71034836
5	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.92033623
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.51822373
7	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.49191459
8	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.48667064
9	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.31343853
10	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.28423001
11	MYB_26560356_Chip-Seq_TH2_Human	2.20570790
12	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.20286848
13	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.15904929
14	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.13854347
15	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.99131732
16	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.98356412
17	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.94741828
18	VDR_22108803_ChIP-Seq_LS180_Human	1.89799262
19	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.87099252
20	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.85762411
21	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.85082532
22	VDR_23849224_ChIP-Seq_CD4+_Human	1.82174126
23	RUNX_20019798_ChIP-Seq_JUKART_Human	1.74170563
24	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.68166727
25	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.56786915
26	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.47782985
27	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.47396780
28	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.47342137
29	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.46255087
30	TP53_22573176_ChIP-Seq_HFKS_Human	1.45101681
31	EZH2_22144423_ChIP-Seq_EOC_Human	1.42273472
32	ELK1_19687146_ChIP-ChIP_HELA_Human	1.39826049
33	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	1.39609233
34	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.38300792
35	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.38300792
36	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.35730283
37	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.35242376
38	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.33036948
39	GATA3_27048872_Chip-Seq_THYMUS_Human	1.31653879
40	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.31543018
41	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.31506413
42	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.29772387
43	EWS_26573619_Chip-Seq_HEK293_Human	1.29489384
44	MYB_26560356_Chip-Seq_TH1_Human	1.29235332
45	GATA3_26560356_Chip-Seq_TH2_Human	1.28795214
46	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.28234661
47	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.26677349
48	IGF1R_20145208_ChIP-Seq_DFB_Human	1.26524112
49	ZNF274_21170338_ChIP-Seq_K562_Hela	1.25657562
50	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.20212247
51	FOXP3_21729870_ChIP-Seq_TREG_Human	1.20204015
52	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.18474627
53	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.18040955
54	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.17688132
55	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.15790301
56	SCL_19346495_ChIP-Seq_HPC-7_Human	1.14906358
57	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.14830997
58	IRF1_19129219_ChIP-ChIP_H3396_Human	1.14302342
59	TAF2_19829295_ChIP-Seq_ESCs_Human	1.14145635
60	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.13836490
61	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.13443815
62	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.12730091
63	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.11664692
64	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.11105954
65	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.09675849
66	CBP_20019798_ChIP-Seq_JUKART_Human	1.09675849
67	SOX2_19829295_ChIP-Seq_ESCs_Human	1.09144613
68	NANOG_19829295_ChIP-Seq_ESCs_Human	1.09144613
69	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.07636359
70	HTT_18923047_ChIP-ChIP_STHdh_Human	1.05658913
71	AR_20517297_ChIP-Seq_VCAP_Human	1.05580357
72	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.03479602
73	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.01868159
74	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.01802585
75	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.99929940
76	BCL6_27268052_Chip-Seq_Bcells_Human	0.99835227
77	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.99472439
78	NCOR_22424771_ChIP-Seq_293T_Human	0.98694971
79	SPI1_23547873_ChIP-Seq_NB4_Human	0.97621580
80	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.97464861
81	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.97261459
82	CTCF_20526341_ChIP-Seq_ESCs_Human	0.96758031
83	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.96155268
84	RBPJ_21746931_ChIP-Seq_IB4_Human	0.94728400
85	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	0.93889636
86	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.93789621
87	ER_23166858_ChIP-Seq_MCF-7_Human	0.92630449
88	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.91066677
89	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.90992157
90	UTX_26944678_Chip-Seq_JUKART_Human	0.88450454
91	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.88290008
92	NANOG_20526341_ChIP-Seq_ESCs_Human	0.87285035
93	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.87249315
94	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.87232443
95	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.86232783
96	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.85743133
97	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	0.84614407
98	ERG_20517297_ChIP-Seq_VCAP_Human	0.83626583
99	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	0.83098251
100	FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse	0.82528119

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.01711807
2	MP0005671_abnormal_response_to	4.29695331
3	MP0001873_stomach_inflammation	3.79118607
4	MP0001835_abnormal_antigen_presentation	2.97622401
5	MP0006082_CNS_inflammation	2.95293595
6	MP0003724_increased_susceptibility_to	2.72634436
7	MP0002148_abnormal_hypersensitivity_rea	2.66338227
8	MP0002102_abnormal_ear_morphology	2.56220405
9	MP0005000_abnormal_immune_tolerance	2.49074130
10	MP0000372_irregular_coat_pigmentation	2.46723678
11	MP0003763_abnormal_thymus_physiology	2.35713479
12	MP0001188_hyperpigmentation	2.35638154
13	MP0009785_altered_susceptibility_to	2.33259119
14	MP0001800_abnormal_humoral_immune	2.32516226
15	MP0009333_abnormal_splenocyte_physiolog	2.16167523
16	MP0008872_abnormal_physiological_respon	2.10153776
17	MP0002420_abnormal_adaptive_immunity	1.97174090
18	MP0008875_abnormal_xenobiotic_pharmacok	1.96757224
19	MP0002723_abnormal_immune_serum	1.95580791
20	MP0001819_abnormal_immune_cell	1.89568819
21	MP0005387_immune_system_phenotype	1.79570855
22	MP0001790_abnormal_immune_system	1.79570855
23	MP0005025_abnormal_response_to	1.65708564
24	MP0002398_abnormal_bone_marrow	1.64697909
25	MP0002452_abnormal_antigen_presenting	1.63113062
26	MP0003646_muscle_fatigue	1.62797903
27	MP0001348_abnormal_lacrimal_gland	1.60422559
28	MP0000716_abnormal_immune_system	1.58266360
29	MP0005464_abnormal_platelet_physiology	1.55720287
30	MP0008877_abnormal_DNA_methylation	1.52520883
31	MP0002163_abnormal_gland_morphology	1.48015474
32	MP0000685_abnormal_immune_system	1.47942427
33	MP0005075_abnormal_melanosome_morpholog	1.46716703
34	MP0008995_early_reproductive_senescence	1.46017683
35	MP0010155_abnormal_intestine_physiology	1.43609174
36	MP0002405_respiratory_system_inflammati	1.42868537
37	MP0002722_abnormal_immune_system	1.42762852
38	MP0001919_abnormal_reproductive_system	1.41224015
39	MP0002837_dystrophic_cardiac_calcinosis	1.39138748
40	MP0005389_reproductive_system_phenotype	1.38484953
41	MP0003866_abnormal_defecation	1.37084557
42	MP0004885_abnormal_endolymph	1.36545752
43	MP0003283_abnormal_digestive_organ	1.35683791
44	MP0000703_abnormal_thymus_morphology	1.33384777
45	MP0002160_abnormal_reproductive_system	1.32423157
46	MP0005310_abnormal_salivary_gland	1.26570869
47	MP0003786_premature_aging	1.26346234
48	MP0006054_spinal_hemorrhage	1.24127908
49	MP0002429_abnormal_blood_cell	1.21487338
50	MP0006276_abnormal_autonomic_nervous	1.19213042
51	MP0000689_abnormal_spleen_morphology	1.19075740
52	MP0001845_abnormal_inflammatory_respons	1.19027388
53	MP0000613_abnormal_salivary_gland	1.17558584
54	MP0003137_abnormal_impulse_conducting	1.12920700
55	MP0003436_decreased_susceptibility_to	1.11031863
56	MP0002876_abnormal_thyroid_physiology	1.10753090
57	MP0002234_abnormal_pharynx_morphology	1.10498306
58	MP0009384_cardiac_valve_regurgitation	1.08909030
59	MP0006072_abnormal_retinal_apoptosis	1.08826218
60	MP0003195_calcinosis	1.07215981
61	MP0002419_abnormal_innate_immunity	1.04645570
62	MP0002933_joint_inflammation	1.04496260
63	MP0002277_abnormal_respiratory_mucosa	1.01041046
64	MP0002166_altered_tumor_susceptibility	0.99069565
65	MP0003880_abnormal_central_pattern	0.97575556
66	MP0005645_abnormal_hypothalamus_physiol	0.97271585
67	MP0003011_delayed_dark_adaptation	0.94519283
68	MP0000013_abnormal_adipose_tissue	0.92378288
69	MP0003183_abnormal_peptide_metabolism	0.91437131
70	MP0002006_tumorigenesis	0.90483133
71	MP0004742_abnormal_vestibular_system	0.89762287
72	MP0004381_abnormal_hair_follicle	0.89601912
73	MP0001663_abnormal_digestive_system	0.89262167
74	MP0001984_abnormal_olfaction	0.88802062
75	MP0000678_abnormal_parathyroid_gland	0.88091721
76	MP0005410_abnormal_fertilization	0.86450458
77	MP0001905_abnormal_dopamine_level	0.86247030
78	MP0001485_abnormal_pinna_reflex	0.85134654
79	MP0008469_abnormal_protein_level	0.84688437
80	MP0006292_abnormal_olfactory_placode	0.83835120
81	MP0005551_abnormal_eye_electrophysiolog	0.78800276
82	MP0010386_abnormal_urinary_bladder	0.78123800
83	MP0002693_abnormal_pancreas_physiology	0.78045835
84	MP0005084_abnormal_gallbladder_morpholo	0.77644580
85	MP0002736_abnormal_nociception_after	0.76869057
86	MP0001853_heart_inflammation	0.74353734
87	MP0005646_abnormal_pituitary_gland	0.73480397
88	MP0002138_abnormal_hepatobiliary_system	0.72446587
89	MP0001968_abnormal_touch/_nociception	0.71778879
90	MP0005623_abnormal_meninges_morphology	0.70780594
91	MP0000049_abnormal_middle_ear	0.68948331
92	MP0001502_abnormal_circadian_rhythm	0.68368326
93	MP0008789_abnormal_olfactory_epithelium	0.64270542
94	MP0005085_abnormal_gallbladder_physiolo	0.64023187
95	MP0004147_increased_porphyrin_level	0.64005373
96	MP0001963_abnormal_hearing_physiology	0.62743612
97	MP0005636_abnormal_mineral_homeostasis	0.61688660
98	MP0009643_abnormal_urine_homeostasis	0.61431011
99	MP0005379_endocrine/exocrine_gland_phen	0.61323355
100	MP0009745_abnormal_behavioral_response	0.61161541

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Aplastic anemia (HP:0001915)	4.64824948
2	Autoimmune hemolytic anemia (HP:0001890)	4.41831312
3	Congenital stationary night blindness (HP:0007642)	4.39506873
4	Autoimmune thrombocytopenia (HP:0001973)	4.02617941
5	Decreased electroretinogram (ERG) amplitude (HP:0000654)	4.01546425
6	Elevated erythrocyte sedimentation rate (HP:0003565)	3.85083547
7	IgG deficiency (HP:0004315)	3.79970940
8	Hypoproteinemia (HP:0003075)	3.78908652
9	Stomatitis (HP:0010280)	3.77441106
10	Increased IgM level (HP:0003496)	3.46800441
11	Abnormality of B cell number (HP:0010975)	3.45257581
12	Abnormality of T cell number (HP:0011839)	3.30860104
13	Methylmalonic acidemia (HP:0002912)	3.20604906
14	Abnormality of the prostate (HP:0008775)	3.19491000
15	Hypoplasia of the fovea (HP:0007750)	2.96612248
16	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.96612248
17	Decreased central vision (HP:0007663)	2.92424978
18	Fused cervical vertebrae (HP:0002949)	2.91695846
19	Abnormality of T cells (HP:0002843)	2.91059655
20	Dyschromatopsia (HP:0007641)	2.88261660
21	T lymphocytopenia (HP:0005403)	2.82863214
22	Methylmalonic aciduria (HP:0012120)	2.82468501
23	Eosinophilia (HP:0001880)	2.70454573
24	Abnormality of eosinophils (HP:0001879)	2.62784674
25	Abnormality of T cell physiology (HP:0011840)	2.60843138
26	Severe combined immunodeficiency (HP:0004430)	2.52580792
27	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.48859641
28	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.48859641
29	Mitochondrial inheritance (HP:0001427)	2.48436404
30	Stomach cancer (HP:0012126)	2.47988871
31	3-Methylglutaconic aciduria (HP:0003535)	2.47545049
32	Acute necrotizing encephalopathy (HP:0006965)	2.44502729
33	Abnormal number of erythroid precursors (HP:0012131)	2.41065638
34	Posterior subcapsular cataract (HP:0007787)	2.37763955
35	Abnormality of the fovea (HP:0000493)	2.35801733
36	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.35343086
37	Attenuation of retinal blood vessels (HP:0007843)	2.33771017
38	Metabolic alkalosis (HP:0200114)	2.32852402
39	B lymphocytopenia (HP:0010976)	2.32620891
40	Reduced antithrombin III activity (HP:0001976)	2.32309951
41	Carpal bone hypoplasia (HP:0001498)	2.30297534
42	Metaphyseal dysplasia (HP:0100255)	2.28345378
43	Alveolar cell carcinoma (HP:0006519)	2.26223176
44	Visual hallucinations (HP:0002367)	2.24524376
45	Leukocytosis (HP:0001974)	2.24027222
46	Hyperglycinemia (HP:0002154)	2.21722814
47	Unilateral renal agenesis (HP:0000122)	2.21087749
48	Abnormality of cells of the erythroid lineage (HP:0012130)	2.20527905
49	Cone-rod dystrophy (HP:0000548)	2.20338609
50	Abnormal mitochondria in muscle tissue (HP:0008316)	2.19697750
51	Abnormal albumin level (HP:0012116)	2.18724550
52	Hypoalbuminemia (HP:0003073)	2.18724550
53	Vasculitis (HP:0002633)	2.18677625
54	Ketosis (HP:0001946)	2.18064466
55	Testicular atrophy (HP:0000029)	2.17934807
56	Oral leukoplakia (HP:0002745)	2.15589916
57	Abnormality of cells of the lymphoid lineage (HP:0012140)	2.15247782
58	Chronic diarrhea (HP:0002028)	2.14334827
59	Aplasia/Hypoplasia of the macula (HP:0008059)	2.13638933
60	Thyroiditis (HP:0100646)	2.12639242
61	Lymphopenia (HP:0001888)	2.11129522
62	Granulocytopenia (HP:0001913)	2.10984122
63	Progressive macrocephaly (HP:0004481)	2.09570245
64	Abnormality of the renal cortex (HP:0011035)	2.09446830
65	Increased CSF lactate (HP:0002490)	2.05282032
66	Hepatocellular necrosis (HP:0001404)	2.03898746
67	Keratoconjunctivitis (HP:0001096)	2.03737000
68	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.03176256
69	Aplasia/hypoplasia of the uterus (HP:0008684)	2.02020251
70	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.01520563
71	Aplasia/Hypoplasia affecting the retina (HP:0008061)	2.01164551
72	Hypokalemic alkalosis (HP:0001949)	1.99142851
73	Retrobulbar optic neuritis (HP:0100654)	1.98179352
74	Optic neuritis (HP:0100653)	1.98179352
75	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	1.95435516
76	Abnormality of male internal genitalia (HP:0000022)	1.93299122
77	Pendular nystagmus (HP:0012043)	1.92685430
78	Neoplasm of the tracheobronchial system (HP:0100552)	1.90949530
79	Hepatic necrosis (HP:0002605)	1.90046662
80	Pancytopenia (HP:0001876)	1.90042512
81	Renal cortical cysts (HP:0000803)	1.88202127
82	Abolished electroretinogram (ERG) (HP:0000550)	1.87928267
83	Encephalitis (HP:0002383)	1.86921274
84	Abnormality of vitamin B metabolism (HP:0004340)	1.86426953
85	Optic disc pallor (HP:0000543)	1.85634891
86	Cutaneous melanoma (HP:0012056)	1.85116137
87	Chorioretinal atrophy (HP:0000533)	1.85013599
88	Colon cancer (HP:0003003)	1.84802165
89	IgM deficiency (HP:0002850)	1.84782281
90	Recurrent abscess formation (HP:0002722)	1.84641311
91	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.83164922
92	Meningitis (HP:0001287)	1.81895474
93	Anomalous pulmonary venous return (HP:0010772)	1.81551946
94	Ureteral stenosis (HP:0000071)	1.79987528
95	Ketoacidosis (HP:0001993)	1.78357312
96	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.77955828
97	Combined immunodeficiency (HP:0005387)	1.76904569
98	Acute encephalopathy (HP:0006846)	1.76664226
99	Abnormality of macular pigmentation (HP:0008002)	1.76458147
100	Rectal fistula (HP:0100590)	1.75550681

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	4.91465604
2	TAOK3	3.87869178
3	KDR	3.43328544
4	GRK6	3.09917608
5	ADRBK2	2.89548146
6	MAP4K1	2.87179467
7	BMPR2	2.79947081
8	CDK19	2.57035803
9	BCKDK	2.20740104
10	VRK2	2.17598605
11	SYK	2.14064906
12	ITK	2.12111922
13	FES	2.11492833
14	PASK	2.09635417
15	PINK1	2.08700035
16	GRK1	1.72844790
17	RIPK4	1.67136561
18	BTK	1.66521531
19	TEC	1.59952867
20	MST4	1.53144035
21	IKBKB	1.51187046
22	NUAK1	1.50084435
23	FRK	1.40584618
24	MAP3K11	1.35582163
25	LCK	1.25445754
26	PIK3CG	1.24376579
27	BLK	1.23658169
28	INSRR	1.22979503
29	BUB1	1.20867235
30	IRAK4	1.19569738
31	FLT3	1.15835235
32	OXSR1	1.13759005
33	GRK7	1.12364110
34	CSF1R	1.12312917
35	LYN	1.12259052
36	STK39	1.07782392
37	TESK2	1.07417870
38	ZAP70	1.06190917
39	MAP4K2	1.04648056
40	VRK1	1.03315540
41	IKBKE	1.02938112
42	MAP2K6	1.02604303
43	BMPR1B	0.99949276
44	CSK	0.98913828
45	PRKCQ	0.98863057
46	JAK3	0.90058868
47	TLK1	0.89796889
48	MYLK	0.86295733
49	MATK	0.74870910
50	TIE1	0.74410735
51	WNK4	0.74225398
52	STK4	0.72871166
53	DAPK2	0.71851155
54	CAMKK1	0.70731915
55	KIT	0.69261000
56	GRK5	0.67296492
57	OBSCN	0.66137412
58	DYRK2	0.64523517
59	ADRBK1	0.62896166
60	MAP3K14	0.59550307
61	TNK2	0.59146255
62	NME2	0.56279885
63	PLK2	0.55264188
64	CAMKK2	0.54573241
65	RPS6KB1	0.54010918
66	MAP3K12	0.53363910
67	WNK3	0.51863653
68	SRPK1	0.51331746
69	EPHA4	0.51226904
70	NEK1	0.50627622
71	PRKCA	0.50275211
72	PIK3CA	0.49749364
73	SCYL2	0.49737547
74	PIM1	0.48903575
75	PBK	0.46953322
76	IGF1R	0.43240794
77	PRKACA	0.43132242
78	TGFBR2	0.41829405
79	PLK4	0.39693008
80	RPS6KA5	0.39653176
81	HCK	0.39618528
82	FYN	0.39154374
83	ABL2	0.37513408
84	JAK2	0.35887518
85	CSNK2A1	0.35568478
86	CSNK2A2	0.35161712
87	MAP3K3	0.34885889
88	PRKACG	0.33903108
89	CSNK1G3	0.33895683
90	MUSK	0.33796194
91	TAOK2	0.33433986
92	PRKCD	0.33301208
93	PRKCB	0.31891244
94	NTRK3	0.31561593
95	ERBB3	0.31137118
96	MARK3	0.31092466
97	TSSK6	0.29412505
98	NTRK1	0.27967655
99	PRKCE	0.27596291
100	PIM2	0.27570079

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Autoimmune thyroid disease_Homo sapiens_hsa05320	4.02615296
2	Allograft rejection_Homo sapiens_hsa05330	4.00222686
3	Asthma_Homo sapiens_hsa05310	3.71213036
4	Primary immunodeficiency_Homo sapiens_hsa05340	3.70322250
5	Graft-versus-host disease_Homo sapiens_hsa05332	3.17251053
6	Ribosome_Homo sapiens_hsa03010	2.99885777
7	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.64794383
8	Type I diabetes mellitus_Homo sapiens_hsa04940	2.55693066
9	Proteasome_Homo sapiens_hsa03050	2.41441542
10	Hematopoietic cell lineage_Homo sapiens_hsa04640	2.36201040
11	RNA polymerase_Homo sapiens_hsa03020	2.30073105
12	Antigen processing and presentation_Homo sapiens_hsa04612	2.28274446
13	Oxidative phosphorylation_Homo sapiens_hsa00190	2.21341096
14	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.16472286
15	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.08169088
16	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.05778081
17	Rheumatoid arthritis_Homo sapiens_hsa05323	1.90879315
18	Nitrogen metabolism_Homo sapiens_hsa00910	1.82504260
19	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.78003044
20	Caffeine metabolism_Homo sapiens_hsa00232	1.67968978
21	Parkinsons disease_Homo sapiens_hsa05012	1.64331453
22	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.52356072
23	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.50426684
24	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.46031981
25	Phototransduction_Homo sapiens_hsa04744	1.44733663
26	Protein export_Homo sapiens_hsa03060	1.44565187
27	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.43662169
28	Viral myocarditis_Homo sapiens_hsa05416	1.41512722
29	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.40594060
30	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.36028864
31	Leishmaniasis_Homo sapiens_hsa05140	1.35401769
32	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.33578800
33	Alzheimers disease_Homo sapiens_hsa05010	1.18405686
34	One carbon pool by folate_Homo sapiens_hsa00670	1.17338701
35	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.15265295
36	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.13062744
37	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.10341218
38	Linoleic acid metabolism_Homo sapiens_hsa00591	1.09638675
39	Fanconi anemia pathway_Homo sapiens_hsa03460	1.01496255
40	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.95975660
41	Pyrimidine metabolism_Homo sapiens_hsa00240	0.92254071
42	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.90206777
43	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.83706986
44	Huntingtons disease_Homo sapiens_hsa05016	0.83169047
45	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.81240257
46	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.79087526
47	Cardiac muscle contraction_Homo sapiens_hsa04260	0.78346547
48	Butanoate metabolism_Homo sapiens_hsa00650	0.78215320
49	Chemical carcinogenesis_Homo sapiens_hsa05204	0.77813231
50	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.76411485
51	RNA degradation_Homo sapiens_hsa03018	0.75620486
52	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.73995667
53	Olfactory transduction_Homo sapiens_hsa04740	0.72137481
54	Purine metabolism_Homo sapiens_hsa00230	0.71865576
55	Measles_Homo sapiens_hsa05162	0.70609966
56	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.70131293
57	Malaria_Homo sapiens_hsa05144	0.69411871
58	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.68350465
59	Spliceosome_Homo sapiens_hsa03040	0.61074139
60	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.56776655
61	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.55964399
62	Retinol metabolism_Homo sapiens_hsa00830	0.54964926
63	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.52852359
64	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.52568499
65	Herpes simplex infection_Homo sapiens_hsa05168	0.51913475
66	Homologous recombination_Homo sapiens_hsa03440	0.51467927
67	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.49527788
68	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.49297999
69	RNA transport_Homo sapiens_hsa03013	0.46481703
70	Basal transcription factors_Homo sapiens_hsa03022	0.46279238
71	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.43541673
72	Propanoate metabolism_Homo sapiens_hsa00640	0.43401104
73	Tryptophan metabolism_Homo sapiens_hsa00380	0.41967524
74	Ether lipid metabolism_Homo sapiens_hsa00565	0.41273285
75	Fat digestion and absorption_Homo sapiens_hsa04975	0.40772731
76	Nucleotide excision repair_Homo sapiens_hsa03420	0.40723866
77	African trypanosomiasis_Homo sapiens_hsa05143	0.40480903
78	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.40287883
79	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.40086183
80	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.39216904
81	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.37161464
82	Salivary secretion_Homo sapiens_hsa04970	0.36515362
83	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.34090566
84	Collecting duct acid secretion_Homo sapiens_hsa04966	0.33425848
85	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.33309282
86	Metabolic pathways_Homo sapiens_hsa01100	0.30324390
87	Chemokine signaling pathway_Homo sapiens_hsa04062	0.30097402
88	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.25103643
89	Base excision repair_Homo sapiens_hsa03410	0.24080557
90	Pyruvate metabolism_Homo sapiens_hsa00620	0.23694618
91	Toxoplasmosis_Homo sapiens_hsa05145	0.22222761
92	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.21071621
93	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.17939621
94	Influenza A_Homo sapiens_hsa05164	0.17771243
95	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.17485012
96	Platelet activation_Homo sapiens_hsa04611	0.15323978
97	Taste transduction_Homo sapiens_hsa04742	0.15003024
98	Peroxisome_Homo sapiens_hsa04146	0.14439520
99	p53 signaling pathway_Homo sapiens_hsa04115	0.13482031
100	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.13181754

BTF3P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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