BTF3P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.26941731
2energy coupled proton transport, down electrochemical gradient (GO:0015985)6.94371851
3ATP synthesis coupled proton transport (GO:0015986)6.94371851
4ribosomal large subunit biogenesis (GO:0042273)5.49866965
5protein neddylation (GO:0045116)4.61802100
6viral transcription (GO:0019083)4.56972112
7ribosomal small subunit assembly (GO:0000028)4.56361497
8negative regulation of heart rate (GO:0010459)4.51689808
9respiratory electron transport chain (GO:0022904)4.42969455
10electron transport chain (GO:0022900)4.41224703
11establishment of protein localization to mitochondrial membrane (GO:0090151)4.39043881
12translational termination (GO:0006415)4.37749160
13mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.33428117
14positive regulation of inflammatory response to antigenic stimulus (GO:0002863)4.32772508
15SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.24340690
16cotranslational protein targeting to membrane (GO:0006613)4.16442533
17protein targeting to ER (GO:0045047)4.12495588
18negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)4.09532875
19ATP biosynthetic process (GO:0006754)4.05859660
20establishment of protein localization to endoplasmic reticulum (GO:0072599)3.95375666
21protein localization to endoplasmic reticulum (GO:0070972)3.93840111
22translational elongation (GO:0006414)3.82835507
23nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.75149048
24kynurenine metabolic process (GO:0070189)3.66704289
25exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.63321245
26tryptophan catabolic process (GO:0006569)3.62244403
27indole-containing compound catabolic process (GO:0042436)3.62244403
28indolalkylamine catabolic process (GO:0046218)3.62244403
29positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.61957877
30purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.58119144
31regulation of hypersensitivity (GO:0002883)3.56586090
32purine nucleoside triphosphate biosynthetic process (GO:0009145)3.52678592
33protein complex biogenesis (GO:0070271)3.49419666
34hydrogen ion transmembrane transport (GO:1902600)3.46336789
35positive regulation of protein homodimerization activity (GO:0090073)3.43911927
36positive regulation of mast cell activation involved in immune response (GO:0033008)3.41718028
37positive regulation of mast cell degranulation (GO:0043306)3.41718028
38respiratory chain complex IV assembly (GO:0008535)3.41339940
39sequestering of actin monomers (GO:0042989)3.39369279
40maturation of SSU-rRNA (GO:0030490)3.36866617
41regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.34499128
42proteasome assembly (GO:0043248)3.30219789
43cellular protein complex disassembly (GO:0043624)3.27565104
44mitochondrial respiratory chain complex I assembly (GO:0032981)3.27422308
45NADH dehydrogenase complex assembly (GO:0010257)3.27422308
46mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.27422308
47regulation of cellular amino acid metabolic process (GO:0006521)3.26392960
48negative regulation of mast cell activation (GO:0033004)3.21372725
49chaperone-mediated protein transport (GO:0072321)3.21027362
50proton transport (GO:0015992)3.19240653
51cytochrome complex assembly (GO:0017004)3.18352371
52tryptophan metabolic process (GO:0006568)3.15775424
53hydrogen transport (GO:0006818)3.13472981
54viral life cycle (GO:0019058)3.13095398
55translation (GO:0006412)3.12037744
56nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.11271152
57translational initiation (GO:0006413)3.08790449
58antigen processing and presentation via MHC class Ib (GO:0002475)3.07750901
59positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.06367489
60DNA deamination (GO:0045006)3.05284344
61ribosomal small subunit biogenesis (GO:0042274)3.03145460
62ribonucleoside triphosphate biosynthetic process (GO:0009201)3.01063878
63purine nucleotide salvage (GO:0032261)3.00684573
64mitochondrial respiratory chain complex assembly (GO:0033108)2.99640522
65regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.89868603
66negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.88236009
67positive regulation of mast cell activation (GO:0033005)2.85158995
68xenobiotic catabolic process (GO:0042178)2.83953464
69protein targeting to membrane (GO:0006612)2.83035869
70oxidative phosphorylation (GO:0006119)2.81934616
71termination of RNA polymerase III transcription (GO:0006386)2.80238468
72transcription elongation from RNA polymerase III promoter (GO:0006385)2.80238468
73DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.80011204
74peptidyl-histidine modification (GO:0018202)2.79038589
75otic vesicle formation (GO:0030916)2.76156629
76RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.71588612
77regulation of immunoglobulin secretion (GO:0051023)2.71221018
78signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.70054739
79signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.70054739
80signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.70054739
81maturation of 5.8S rRNA (GO:0000460)2.69814728
82intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.68897542
83signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.68897542
84positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.68756238
85antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.68223288
86purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.67554205
87purine nucleoside monophosphate biosynthetic process (GO:0009127)2.67554205
88pseudouridine synthesis (GO:0001522)2.67374010
89GPI anchor metabolic process (GO:0006505)2.66537207
90negative regulation of T cell differentiation in thymus (GO:0033085)2.64392450
91purine-containing compound salvage (GO:0043101)2.63639640
92protein refolding (GO:0042026)2.62631330
93prenylation (GO:0097354)2.62493226
94protein prenylation (GO:0018342)2.62493226
95regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.62138832
96regulation of chronic inflammatory response (GO:0002676)2.61726866
97antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.61501147
98regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.61056410
99positive regulation of B cell mediated immunity (GO:0002714)2.59570533
100positive regulation of immunoglobulin mediated immune response (GO:0002891)2.59570533

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat6.80024467
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.13728591
3VDR_22108803_ChIP-Seq_LS180_Human3.10480112
4EST1_17652178_ChIP-ChIP_JURKAT_Human2.94157287
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.81899903
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.69952521
7EZH2_22144423_ChIP-Seq_EOC_Human2.67900721
8ZNF274_21170338_ChIP-Seq_K562_Hela2.51231424
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.45601062
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.30655037
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.28549566
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.28455955
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.25910292
14IGF1R_20145208_ChIP-Seq_DFB_Human2.24336741
15TAF15_26573619_Chip-Seq_HEK293_Human2.22417859
16VDR_23849224_ChIP-Seq_CD4+_Human2.16289974
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.01603254
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.00338863
19ZFP57_27257070_Chip-Seq_ESCs_Mouse1.99212994
20ELK1_19687146_ChIP-ChIP_HELA_Human1.92912369
21GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.85911712
22EWS_26573619_Chip-Seq_HEK293_Human1.85810365
23POU3F2_20337985_ChIP-ChIP_501MEL_Human1.81633644
24ETS1_20019798_ChIP-Seq_JURKAT_Human1.74264023
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.72532611
26P300_19829295_ChIP-Seq_ESCs_Human1.67794675
27MYC_18555785_ChIP-Seq_MESCs_Mouse1.65886170
28AR_21572438_ChIP-Seq_LNCaP_Human1.65349380
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.63306144
30SOX2_19829295_ChIP-Seq_ESCs_Human1.62184400
31NANOG_19829295_ChIP-Seq_ESCs_Human1.62184400
32NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.61564552
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58143331
34POU5F1_16153702_ChIP-ChIP_HESCs_Human1.57378325
35JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.56459339
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.56097818
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52694083
38ER_23166858_ChIP-Seq_MCF-7_Human1.48000136
39GBX2_23144817_ChIP-Seq_PC3_Human1.44050593
40ERG_20517297_ChIP-Seq_VCAP_Human1.43859869
41TP53_22573176_ChIP-Seq_HFKS_Human1.39650392
42EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.37103603
43FOXP3_21729870_ChIP-Seq_TREG_Human1.36379141
44FOXA1_27270436_Chip-Seq_PROSTATE_Human1.35815465
45FOXA1_25329375_ChIP-Seq_VCAP_Human1.35815465
46FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.32826462
47FOXA1_21572438_ChIP-Seq_LNCaP_Human1.27630895
48MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24314408
49CBX2_27304074_Chip-Seq_ESCs_Mouse1.24303731
50PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23454548
51CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.23177339
52FOXH1_21741376_ChIP-Seq_EPCs_Human1.21942022
53PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21007390
54UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20900127
55PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.20713125
56MYC_18940864_ChIP-ChIP_HL60_Human1.20416544
57FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.19526590
58AUTS2_25519132_ChIP-Seq_293T-REX_Human1.19090857
59FUS_26573619_Chip-Seq_HEK293_Human1.18726586
60AR_20517297_ChIP-Seq_VCAP_Human1.18549414
61ELK1_22589737_ChIP-Seq_MCF10A_Human1.15928569
62GATA3_26560356_Chip-Seq_TH2_Human1.14592272
63IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.14379510
64GATA3_21878914_ChIP-Seq_MCF-7_Human1.12340505
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11285601
66POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11285601
67BP1_19119308_ChIP-ChIP_Hs578T_Human1.10788934
68CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.10211763
69AR_25329375_ChIP-Seq_VCAP_Human1.10182077
70TAF2_19829295_ChIP-Seq_ESCs_Human1.09074651
71IRF8_22096565_ChIP-ChIP_GC-B_Human1.08999944
72GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.07870681
73IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07822328
74CBP_20019798_ChIP-Seq_JUKART_Human1.07822328
75PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.07509479
76SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06305144
77CREB1_15753290_ChIP-ChIP_HEK293T_Human1.05026691
78EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04886375
79HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.04504104
80NFE2_27457419_Chip-Seq_LIVER_Mouse1.02825208
81TTF2_22483619_ChIP-Seq_HELA_Human1.01953500
82HTT_18923047_ChIP-ChIP_STHdh_Human1.01540842
83POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.99931079
84RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99451506
85KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99246992
86PHF8_20622853_ChIP-Seq_HELA_Human0.98679794
87PRDM14_20953172_ChIP-Seq_ESCs_Human0.98637659
88GATA6_21074721_ChIP-Seq_CACO-2_Human0.98470656
89ETV2_25802403_ChIP-Seq_MESCs_Mouse0.95347382
90SRF_21415370_ChIP-Seq_HL-1_Mouse0.95049314
91EGR1_23403033_ChIP-Seq_LIVER_Mouse0.94745874
92DCP1A_22483619_ChIP-Seq_HELA_Human0.94131225
93TCF4_22108803_ChIP-Seq_LS180_Human0.93725642
94TDRD3_21172665_ChIP-Seq_MCF-7_Human0.93676110
95RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91116035
96BCAT_22108803_ChIP-Seq_LS180_Human0.90293018
97E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.90079098
98GATA3_26560356_Chip-Seq_TH1_Human0.90040504
99NANOG_16153702_ChIP-ChIP_HESCs_Human0.88900360
100CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.88209263

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.84828648
2MP0008875_abnormal_xenobiotic_pharmacok3.54380682
3MP0005671_abnormal_response_to3.53118092
4MP0005451_abnormal_body_composition3.39237053
5MP0009379_abnormal_foot_pigmentation3.14254835
6MP0009785_altered_susceptibility_to2.48570507
7MP0000566_synostosis2.48494955
8MP0005645_abnormal_hypothalamus_physiol2.37841972
9MP0002166_altered_tumor_susceptibility2.37701552
10MP0002102_abnormal_ear_morphology2.35196283
11MP0003806_abnormal_nucleotide_metabolis2.34032194
12MP0006072_abnormal_retinal_apoptosis2.19996676
13MP0002006_tumorigenesis2.06302157
14MP0003880_abnormal_central_pattern1.92812261
15MP0005670_abnormal_white_adipose1.82512076
16MP0001873_stomach_inflammation1.78127948
17MP0005171_absent_coat_pigmentation1.73841919
18MP0001800_abnormal_humoral_immune1.71718219
19MP0003195_calcinosis1.62994547
20MP0002736_abnormal_nociception_after1.62509457
21MP0002148_abnormal_hypersensitivity_rea1.62162923
22MP0003787_abnormal_imprinting1.56396907
23MP0001968_abnormal_touch/_nociception1.56160276
24MP0003724_increased_susceptibility_to1.47744613
25MP0009764_decreased_sensitivity_to1.44105333
26MP0006292_abnormal_olfactory_placode1.42878023
27MP0008872_abnormal_physiological_respon1.41691425
28MP0004145_abnormal_muscle_electrophysio1.39817175
29MP0000631_abnormal_neuroendocrine_gland1.38335336
30MP0000372_irregular_coat_pigmentation1.37978969
31MP0002938_white_spotting1.35915512
32MP0005387_immune_system_phenotype1.35116144
33MP0001790_abnormal_immune_system1.35116144
34MP0005084_abnormal_gallbladder_morpholo1.34914928
35MP0003011_delayed_dark_adaptation1.30183981
36MP0003136_yellow_coat_color1.27871497
37MP0008877_abnormal_DNA_methylation1.27124192
38MP0005551_abnormal_eye_electrophysiolog1.25611666
39MP0003866_abnormal_defecation1.25524247
40MP0001905_abnormal_dopamine_level1.24027989
41MP0008058_abnormal_DNA_repair1.23481218
42MP0002452_abnormal_antigen_presenting1.22439346
43MP0004885_abnormal_endolymph1.21435208
44MP0000685_abnormal_immune_system1.18785655
45MP0005000_abnormal_immune_tolerance1.18586670
46MP0001485_abnormal_pinna_reflex1.18337960
47MP0010155_abnormal_intestine_physiology1.18194881
48MP0008995_early_reproductive_senescence1.18112902
49MP0004742_abnormal_vestibular_system1.17785472
50MP0002723_abnormal_immune_serum1.16084424
51MP0004142_abnormal_muscle_tone1.15580352
52MP0003646_muscle_fatigue1.13167601
53MP0005085_abnormal_gallbladder_physiolo1.11666153
54MP0005408_hypopigmentation1.10663043
55MP0002277_abnormal_respiratory_mucosa1.09195607
56MP0002234_abnormal_pharynx_morphology1.05040875
57MP0002282_abnormal_trachea_morphology1.05029943
58MP0005253_abnormal_eye_physiology1.04904327
59MP0003183_abnormal_peptide_metabolism1.03714377
60MP0006036_abnormal_mitochondrial_physio0.98565990
61MP0001819_abnormal_immune_cell0.97751910
62MP0002138_abnormal_hepatobiliary_system0.97299601
63MP0000049_abnormal_middle_ear0.97044616
64MP0009333_abnormal_splenocyte_physiolog0.96409793
65MP0002420_abnormal_adaptive_immunity0.96019577
66MP0000383_abnormal_hair_follicle0.94465127
67MP0005646_abnormal_pituitary_gland0.93861964
68MP0006082_CNS_inflammation0.93753280
69MP0001970_abnormal_pain_threshold0.93494235
70MP0001963_abnormal_hearing_physiology0.93450776
71MP0001529_abnormal_vocalization0.93444255
72MP0003283_abnormal_digestive_organ0.92902778
73MP0005075_abnormal_melanosome_morpholog0.91963118
74MP0002733_abnormal_thermal_nociception0.91841961
75MP0006276_abnormal_autonomic_nervous0.91222545
76MP0005377_hearing/vestibular/ear_phenot0.89434495
77MP0003878_abnormal_ear_physiology0.89434495
78MP0005503_abnormal_tendon_morphology0.86695329
79MP0003436_decreased_susceptibility_to0.86519280
80MP0001533_abnormal_skeleton_physiology0.85461715
81MP0001293_anophthalmia0.84913148
82MP0005025_abnormal_response_to0.84394151
83MP0001346_abnormal_lacrimal_gland0.82477850
84MP0001919_abnormal_reproductive_system0.79291747
85MP0009745_abnormal_behavioral_response0.76041368
86MP0000026_abnormal_inner_ear0.75840606
87MP0002272_abnormal_nervous_system0.75564402
88MP0001853_heart_inflammation0.75436304
89MP0003252_abnormal_bile_duct0.75302053
90MP0003938_abnormal_ear_development0.73684345
91MP0005367_renal/urinary_system_phenotyp0.72706255
92MP0000516_abnormal_urinary_system0.72706255
93MP0010030_abnormal_orbit_morphology0.72678071
94MP0002095_abnormal_skin_pigmentation0.71756123
95MP0002419_abnormal_innate_immunity0.71152646
96MP0005423_abnormal_somatic_nervous0.70580382
97MP0003186_abnormal_redox_activity0.70340080
98MP0009697_abnormal_copulation0.70011736
99MP0005636_abnormal_mineral_homeostasis0.69130807
100MP0001845_abnormal_inflammatory_respons0.69054977

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.18045341
2Aplastic anemia (HP:0001915)4.06622018
3Congenital, generalized hypertrichosis (HP:0004540)4.04038345
4Increased hepatocellular lipid droplets (HP:0006565)4.01193726
5Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.97747277
6Abnormality of alanine metabolism (HP:0010916)3.97747277
7Hyperalaninemia (HP:0003348)3.97747277
8Mitochondrial inheritance (HP:0001427)3.86422362
9Progressive macrocephaly (HP:0004481)3.71540864
10Stenosis of the external auditory canal (HP:0000402)3.62314886
11Lipid accumulation in hepatocytes (HP:0006561)3.54854220
12Increased CSF lactate (HP:0002490)3.54755746
13Abnormal mitochondria in muscle tissue (HP:0008316)3.48760119
14Stomatitis (HP:0010280)3.42574901
15Abnormality of the phalanges of the 2nd finger (HP:0009541)3.40978588
163-Methylglutaconic aciduria (HP:0003535)3.31565929
17Methylmalonic acidemia (HP:0002912)3.26517405
18Type 2 muscle fiber atrophy (HP:0003554)3.18675238
19Elevated erythrocyte sedimentation rate (HP:0003565)3.17166195
20IgG deficiency (HP:0004315)3.13517558
21Acute encephalopathy (HP:0006846)3.11897796
22Exertional dyspnea (HP:0002875)3.06606062
23Renal Fanconi syndrome (HP:0001994)2.90386637
24Split foot (HP:0001839)2.83676399
25Hepatocellular necrosis (HP:0001404)2.81930366
26Macrocytic anemia (HP:0001972)2.81732432
27Degeneration of the lateral corticospinal tracts (HP:0002314)2.78778637
28Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.78778637
29Abnormality of the parietal bone (HP:0002696)2.78272354
30Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.75947599
31Cerebral edema (HP:0002181)2.60732752
32Testicular atrophy (HP:0000029)2.59487387
33Hepatic necrosis (HP:0002605)2.55150350
34Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.51341226
35Muscle fiber atrophy (HP:0100295)2.50307090
36Abnormality of the middle phalanges of the toes (HP:0010183)2.50259639
37Hypoplasia of the ulna (HP:0003022)2.49753281
38Partial duplication of thumb phalanx (HP:0009944)2.49390075
39Abnormality of the prostate (HP:0008775)2.41747903
40Abnormality of the labia minora (HP:0012880)2.36800677
41Increased intramyocellular lipid droplets (HP:0012240)2.34975191
42Aplasia/Hypoplasia of the ulna (HP:0006495)2.32777841
43B lymphocytopenia (HP:0010976)2.32724818
44Reticulocytopenia (HP:0001896)2.31346701
45Decreased central vision (HP:0007663)2.28247537
46Abnormality of midbrain morphology (HP:0002418)2.26908044
47Molar tooth sign on MRI (HP:0002419)2.26908044
48Partial duplication of the phalanx of hand (HP:0009999)2.26405705
49Optic disc pallor (HP:0000543)2.25230900
50Megalencephaly (HP:0001355)2.24432708
51Hypoproteinemia (HP:0003075)2.21104730
52Nephronophthisis (HP:0000090)2.20566162
53Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.17934275
54True hermaphroditism (HP:0010459)2.17747990
55Increased serum lactate (HP:0002151)2.17453418
56Absent rod-and cone-mediated responses on ERG (HP:0007688)2.11315533
57Pallor (HP:0000980)2.10340262
58Abnormality of urine glucose concentration (HP:0011016)2.08699811
59Glycosuria (HP:0003076)2.08699811
60Triphalangeal thumb (HP:0001199)2.08362986
61Lactic acidosis (HP:0003128)2.04784468
62Leukodystrophy (HP:0002415)2.04578291
63Abnormality of the vitamin B12 metabolism (HP:0004341)2.03400759
64Methylmalonic aciduria (HP:0012120)2.02929919
65Decreased activity of mitochondrial respiratory chain (HP:0008972)2.02741829
66Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.02741829
67Hyperphosphaturia (HP:0003109)2.01078082
68Abnormality of cells of the erythroid lineage (HP:0012130)2.00524073
69Dyschromatopsia (HP:0007641)1.98915655
70Abnormality of B cell number (HP:0010975)1.98033989
71Homocystinuria (HP:0002156)1.97426187
72Abnormality of homocysteine metabolism (HP:0010919)1.97426187
73Abnormal rod and cone electroretinograms (HP:0008323)1.96101223
74Abnormality of the 2nd finger (HP:0004100)1.95904927
75Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.94621044
76Supernumerary bones of the axial skeleton (HP:0009144)1.94152691
77Abolished electroretinogram (ERG) (HP:0000550)1.94098784
78Pancreatic cysts (HP:0001737)1.93793588
79Aplasia involving bones of the extremities (HP:0009825)1.92438493
80Aplasia involving bones of the upper limbs (HP:0009823)1.92438493
81Aplasia of the phalanges of the hand (HP:0009802)1.92438493
82Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.90355944
83Generalized aminoaciduria (HP:0002909)1.90012096
84Short phalanx of the thumb (HP:0009660)1.89802122
85Abnormality of vitamin B metabolism (HP:0004340)1.88596433
86Medulloblastoma (HP:0002885)1.86691507
87Forearm undergrowth (HP:0009821)1.85196730
88Increased muscle lipid content (HP:0009058)1.83364695
89Symphalangism affecting the phalanges of the hand (HP:0009773)1.83043155
90Bilateral microphthalmos (HP:0007633)1.81220037
91Abnormality of renal resorption (HP:0011038)1.80319465
92Focal motor seizures (HP:0011153)1.79641192
93Abnormality of aspartate family amino acid metabolism (HP:0010899)1.79182603
94Radial bowing (HP:0002986)1.78989571
95Respiratory failure (HP:0002878)1.78963485
96Chronic mucocutaneous candidiasis (HP:0002728)1.77864180
97Recurrent cutaneous fungal infections (HP:0011370)1.77864180
98Abnormality of methionine metabolism (HP:0010901)1.74171074
99Recurrent corneal erosions (HP:0000495)1.74023060
100Congenital stationary night blindness (HP:0007642)1.73872804

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK194.65040958
2BMPR23.95901452
3NUAK13.34293546
4MAP3K122.98126054
5ADRBK22.72793075
6MAP4K22.38572147
7TLK12.35124691
8PASK2.16161789
9ERBB32.09424999
10GRK12.00526068
11MYLK1.98536280
12ZAK1.94899108
13BCKDK1.93354112
14PINK11.89159531
15KDR1.77108507
16TXK1.71442920
17MST41.59972950
18SCYL21.56558410
19NME11.43408397
20WNK31.40034654
21FRK1.38465951
22NEK11.37689979
23FGFR21.34691297
24PIK3CG1.32655683
25KIT1.32087040
26TEC1.27434772
27EIF2AK31.26688932
28TAOK31.24701569
29INSRR1.23873444
30LATS11.21459412
31DYRK21.16856297
32EIF2AK11.14627234
33FLT31.13853711
34OXSR11.13349089
35VRK11.11553314
36VRK21.09412376
37OBSCN1.07711214
38CAMKK21.06924887
39ILK1.04222632
40NME21.03987482
41CSF1R1.03438379
42TRPM70.97561925
43PDK20.97332879
44FGFR10.97200642
45ITK0.95121927
46MKNK10.87946817
47SYK0.86865344
48IKBKB0.86255130
49MAP3K60.83932518
50CDK80.82570224
51RIPK40.78687377
52BTK0.75645594
53BUB10.75312207
54TIE10.72937727
55CSNK1G20.71336687
56ADRBK10.71328389
57TRIM280.71277473
58WNK40.69096473
59MKNK20.67166577
60CAMKK10.64505547
61PLK30.61419859
62CSNK1G30.61232216
63RPS6KA50.61135842
64GRK70.59466318
65AURKB0.57528059
66RPS6KA40.57381380
67ROCK10.57026549
68LYN0.56436811
69PAK40.56169517
70TSSK60.55243990
71DAPK30.54656069
72MAP4K10.54368468
73TESK20.54144807
74CSNK1A1L0.53924087
75LIMK10.53670665
76IGF1R0.53518130
77PAK10.50818083
78ZAP700.50640969
79LCK0.50555669
80PRKACA0.48208023
81CSNK2A10.44497381
82CSNK1G10.43385163
83CSNK2A20.43340118
84PRKG10.40590490
85MAP3K40.40475320
86PRKCA0.39596475
87GRK60.39345412
88MUSK0.38851615
89MINK10.38028333
90ALK0.37771992
91WNK10.37407995
92EGFR0.37012043
93CASK0.36808573
94PRKCG0.36565670
95PLK10.36168226
96PRKCE0.36130705
97ABL10.34523685
98CAMK2A0.34285865
99BRSK20.33446194
100TAOK20.33307677

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053105.20600770
2Ribosome_Homo sapiens_hsa030103.76290057
3Oxidative phosphorylation_Homo sapiens_hsa001903.74775373
4Allograft rejection_Homo sapiens_hsa053303.61459677
5Autoimmune thyroid disease_Homo sapiens_hsa053203.44308490
6Proteasome_Homo sapiens_hsa030503.43541520
7Intestinal immune network for IgA production_Homo sapiens_hsa046723.17869523
8Caffeine metabolism_Homo sapiens_hsa002323.08291761
9Graft-versus-host disease_Homo sapiens_hsa053322.94691112
10Parkinsons disease_Homo sapiens_hsa050122.90917633
11Type I diabetes mellitus_Homo sapiens_hsa049402.72842643
12Protein export_Homo sapiens_hsa030602.59797228
13Cardiac muscle contraction_Homo sapiens_hsa042602.12767981
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.08019086
15Antigen processing and presentation_Homo sapiens_hsa046122.01743608
16Alzheimers disease_Homo sapiens_hsa050101.96531608
17Huntingtons disease_Homo sapiens_hsa050161.83977197
18Primary immunodeficiency_Homo sapiens_hsa053401.72816587
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.68726204
20Rheumatoid arthritis_Homo sapiens_hsa053231.65434437
21RNA polymerase_Homo sapiens_hsa030201.58830482
22Viral myocarditis_Homo sapiens_hsa054161.55036877
23Staphylococcus aureus infection_Homo sapiens_hsa051501.37669795
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.30570280
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.29498967
26RNA degradation_Homo sapiens_hsa030181.26123205
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.25324914
28One carbon pool by folate_Homo sapiens_hsa006701.23300720
29Systemic lupus erythematosus_Homo sapiens_hsa053221.22691745
30Hematopoietic cell lineage_Homo sapiens_hsa046401.22335134
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.08779863
32Leishmaniasis_Homo sapiens_hsa051401.07400491
33Primary bile acid biosynthesis_Homo sapiens_hsa001200.85659481
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.85105054
35Collecting duct acid secretion_Homo sapiens_hsa049660.82762527
36Basal transcription factors_Homo sapiens_hsa030220.80289700
37Phototransduction_Homo sapiens_hsa047440.80070770
38Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77059290
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75225515
40Spliceosome_Homo sapiens_hsa030400.74149691
41Nucleotide excision repair_Homo sapiens_hsa034200.73344737
42Chemical carcinogenesis_Homo sapiens_hsa052040.73219990
43Homologous recombination_Homo sapiens_hsa034400.71925944
44Drug metabolism - other enzymes_Homo sapiens_hsa009830.70604035
45Pyrimidine metabolism_Homo sapiens_hsa002400.69030266
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.64658626
47Purine metabolism_Homo sapiens_hsa002300.62809537
48Nitrogen metabolism_Homo sapiens_hsa009100.62008062
49Olfactory transduction_Homo sapiens_hsa047400.61880655
50Fanconi anemia pathway_Homo sapiens_hsa034600.61763057
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60335473
52Propanoate metabolism_Homo sapiens_hsa006400.58951277
53Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56950292
54Tryptophan metabolism_Homo sapiens_hsa003800.56739676
55Taste transduction_Homo sapiens_hsa047420.55160786
56Mismatch repair_Homo sapiens_hsa034300.54072768
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54068376
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.52979973
59Regulation of autophagy_Homo sapiens_hsa041400.52842723
60Linoleic acid metabolism_Homo sapiens_hsa005910.51056263
61Peroxisome_Homo sapiens_hsa041460.50971988
62Folate biosynthesis_Homo sapiens_hsa007900.50084284
63RNA transport_Homo sapiens_hsa030130.49942477
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49588216
65Starch and sucrose metabolism_Homo sapiens_hsa005000.46479609
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41308998
67Steroid hormone biosynthesis_Homo sapiens_hsa001400.40560425
68Salivary secretion_Homo sapiens_hsa049700.40042193
69Phagosome_Homo sapiens_hsa041450.39148822
70Metabolic pathways_Homo sapiens_hsa011000.38806680
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.38203604
72Ether lipid metabolism_Homo sapiens_hsa005650.37283263
73Serotonergic synapse_Homo sapiens_hsa047260.33922658
74NOD-like receptor signaling pathway_Homo sapiens_hsa046210.33753564
75T cell receptor signaling pathway_Homo sapiens_hsa046600.33479679
76Tuberculosis_Homo sapiens_hsa051520.32913425
77Retinol metabolism_Homo sapiens_hsa008300.30902704
78Steroid biosynthesis_Homo sapiens_hsa001000.29729900
79Toxoplasmosis_Homo sapiens_hsa051450.29376296
80Herpes simplex infection_Homo sapiens_hsa051680.27915457
81Sulfur metabolism_Homo sapiens_hsa009200.27639640
82Pyruvate metabolism_Homo sapiens_hsa006200.26882715
83DNA replication_Homo sapiens_hsa030300.26665323
84Fatty acid biosynthesis_Homo sapiens_hsa000610.25377767
85Butanoate metabolism_Homo sapiens_hsa006500.25364014
86Histidine metabolism_Homo sapiens_hsa003400.25224167
87Epstein-Barr virus infection_Homo sapiens_hsa051690.24577430
88Glutathione metabolism_Homo sapiens_hsa004800.20973894
89GABAergic synapse_Homo sapiens_hsa047270.20532064
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.19642696
91African trypanosomiasis_Homo sapiens_hsa051430.19507052
92Arachidonic acid metabolism_Homo sapiens_hsa005900.19043366
93Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.18462104
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.17733886
95Nicotine addiction_Homo sapiens_hsa050330.17615715
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.15259428
97Morphine addiction_Homo sapiens_hsa050320.15028921
98Base excision repair_Homo sapiens_hsa034100.13186556
99Pertussis_Homo sapiens_hsa051330.11901631
100Circadian entrainment_Homo sapiens_hsa047130.11462789

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »