BTF3P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)8.04826076
2viral transcription (GO:0019083)6.66529924
3translational termination (GO:0006415)6.28926950
4ribosomal small subunit biogenesis (GO:0042274)5.87817963
5energy coupled proton transport, down electrochemical gradient (GO:0015985)5.71817547
6ATP synthesis coupled proton transport (GO:0015986)5.71817547
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.50865289
8translational elongation (GO:0006414)5.42513665
9cotranslational protein targeting to membrane (GO:0006613)5.36206321
10protein targeting to ER (GO:0045047)5.28185714
11establishment of protein localization to endoplasmic reticulum (GO:0072599)4.98184036
12protein localization to endoplasmic reticulum (GO:0070972)4.94524369
13translational initiation (GO:0006413)4.86675171
14phenylpropanoid metabolic process (GO:0009698)4.76605741
15maturation of SSU-rRNA (GO:0030490)4.74650194
16cellular protein complex disassembly (GO:0043624)4.66281406
17nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.66000248
18xenobiotic catabolic process (GO:0042178)4.64163111
19pseudouridine synthesis (GO:0001522)4.61408610
20viral life cycle (GO:0019058)4.55776302
21exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.34932032
22nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.33701752
23GTP biosynthetic process (GO:0006183)4.32826960
24ribosomal large subunit biogenesis (GO:0042273)4.31290773
25chaperone-mediated protein transport (GO:0072321)4.26512566
26mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.21648343
27NADH dehydrogenase complex assembly (GO:0010257)4.20096555
28mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.20096555
29mitochondrial respiratory chain complex I assembly (GO:0032981)4.20096555
30translation (GO:0006412)4.09623005
31labyrinthine layer development (GO:0060711)3.94402991
32protein complex biogenesis (GO:0070271)3.89631280
33protein complex disassembly (GO:0043241)3.84991098
34UTP biosynthetic process (GO:0006228)3.82114991
35purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.75112672
36oxygen transport (GO:0015671)3.72343632
37myoblast migration (GO:0051451)3.71416790
38regulation of immunoglobulin secretion (GO:0051023)3.70007956
39mitochondrial respiratory chain complex assembly (GO:0033108)3.69815530
40nuclear-transcribed mRNA catabolic process (GO:0000956)3.68110385
41macromolecular complex disassembly (GO:0032984)3.65641584
42platelet dense granule organization (GO:0060155)3.65444508
43purine nucleoside triphosphate biosynthetic process (GO:0009145)3.63545077
44ribonucleoprotein complex biogenesis (GO:0022613)3.58488396
45guanosine-containing compound biosynthetic process (GO:1901070)3.57730803
46mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.57037860
47ATP biosynthetic process (GO:0006754)3.56887107
48cellular component biogenesis (GO:0044085)3.55339482
49DNA deamination (GO:0045006)3.55113698
50nucleoside diphosphate phosphorylation (GO:0006165)3.52504489
51mRNA catabolic process (GO:0006402)3.51240537
52protein targeting to membrane (GO:0006612)3.51097289
53peptidyl-histidine modification (GO:0018202)3.49018728
54UTP metabolic process (GO:0046051)3.47463823
55positive regulation by symbiont of host defense response (GO:0052509)3.39524961
56modulation by symbiont of host defense response (GO:0052031)3.39524961
57modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.39524961
58modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.39524961
59positive regulation by organism of defense response of other organism involved in symbiotic interact3.39524961
60modulation by symbiont of host immune response (GO:0052553)3.39524961
61respiratory electron transport chain (GO:0022904)3.33586323
62electron transport chain (GO:0022900)3.28253032
63RNA catabolic process (GO:0006401)3.22369764
64serine family amino acid catabolic process (GO:0009071)3.21353650
65ribonucleoside triphosphate biosynthetic process (GO:0009201)3.19019255
66autophagic vacuole fusion (GO:0000046)3.15565608
67pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.12019064
68hydrogen ion transmembrane transport (GO:1902600)3.04316701
69RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.03502138
70drug transmembrane transport (GO:0006855)3.01587628
71rRNA processing (GO:0006364)3.00931473
72N-acetylglucosamine metabolic process (GO:0006044)3.00320216
73establishment of protein localization to mitochondrial membrane (GO:0090151)2.99891470
74deoxyribonucleotide catabolic process (GO:0009264)2.98572095
75rRNA metabolic process (GO:0016072)2.97991702
76protein targeting to mitochondrion (GO:0006626)2.96228900
77deoxyribose phosphate catabolic process (GO:0046386)2.94913699
78nucleoside triphosphate biosynthetic process (GO:0009142)2.94347850
79purine deoxyribonucleotide catabolic process (GO:0009155)2.92077641
80protein-cofactor linkage (GO:0018065)2.90092410
81regulation of mitochondrial translation (GO:0070129)2.88792113
82gas transport (GO:0015669)2.86536248
83benzene-containing compound metabolic process (GO:0042537)2.86477770
84response to nitric oxide (GO:0071731)2.86414401
85rRNA modification (GO:0000154)2.85678450
86positive regulation of digestive system process (GO:0060456)2.83216284
87somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.82959220
88isotype switching (GO:0045190)2.82959220
89somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.82959220
90establishment of protein localization to mitochondrion (GO:0072655)2.79743347
91detection of molecule of bacterial origin (GO:0032490)2.78932348
92regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.78703631
93regulation of mitotic spindle checkpoint (GO:1903504)2.78703631
94positive regulation of prostaglandin secretion (GO:0032308)2.76132072
95proton transport (GO:0015992)2.75682919
96positive regulation of fatty acid transport (GO:2000193)2.70709930
97glycine metabolic process (GO:0006544)2.69701559
98positive regulation of icosanoid secretion (GO:0032305)2.69107868
99hydrogen transport (GO:0006818)2.67284386
100CTP metabolic process (GO:0046036)2.66458637

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.65896705
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.23084887
3ELF1_17652178_ChIP-ChIP_JURKAT_Human3.61916417
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.48443706
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.38032596
6IGF1R_20145208_ChIP-Seq_DFB_Human3.30599998
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.20454586
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.19547462
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.16981916
10VDR_22108803_ChIP-Seq_LS180_Human3.07554055
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.93534888
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.80352115
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.79981207
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.75362721
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.65747218
16ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.48625572
17CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.46403075
18NOTCH1_21737748_ChIP-Seq_TLL_Human2.41874545
19ZNF274_21170338_ChIP-Seq_K562_Hela2.40429405
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.37173195
21VDR_23849224_ChIP-Seq_CD4+_Human2.36653079
22EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.05415831
23FOXP3_21729870_ChIP-Seq_TREG_Human1.89058207
24TTF2_22483619_ChIP-Seq_HELA_Human1.83456339
25SRF_21415370_ChIP-Seq_HL-1_Mouse1.81166654
26EWS_26573619_Chip-Seq_HEK293_Human1.77555439
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77316845
28MYC_18358816_ChIP-ChIP_MESCs_Mouse1.70685907
29EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.69889183
30XRN2_22483619_ChIP-Seq_HELA_Human1.65195482
31IRF1_19129219_ChIP-ChIP_H3396_Human1.60745172
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.52690825
33CREB1_15753290_ChIP-ChIP_HEK293T_Human1.50848666
34GATA3_21878914_ChIP-Seq_MCF-7_Human1.50785824
35HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.50628050
36GABP_19822575_ChIP-Seq_HepG2_Human1.49593960
37DCP1A_22483619_ChIP-Seq_HELA_Human1.44099729
38POU5F1_16153702_ChIP-ChIP_HESCs_Human1.39308330
39PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.37826049
40CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.37322808
41FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.34759703
42GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.32122447
43TP53_22573176_ChIP-Seq_HFKS_Human1.31763884
44AR_20517297_ChIP-Seq_VCAP_Human1.30357811
45EGR1_23403033_ChIP-Seq_LIVER_Mouse1.30085854
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.29647124
47MYC_18940864_ChIP-ChIP_HL60_Human1.29421662
48MYC_19030024_ChIP-ChIP_MESCs_Mouse1.28198109
49CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.26401970
50HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.25815213
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.25656208
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23384449
53THAP11_20581084_ChIP-Seq_MESCs_Mouse1.21524692
54P300_19829295_ChIP-Seq_ESCs_Human1.20990409
55ER_23166858_ChIP-Seq_MCF-7_Human1.20486350
56MYC_19079543_ChIP-ChIP_MESCs_Mouse1.20344151
57NANOG_19829295_ChIP-Seq_ESCs_Human1.18902843
58SOX2_19829295_ChIP-Seq_ESCs_Human1.18902843
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.17330385
60CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16343586
61EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.16064337
62ELK1_19687146_ChIP-ChIP_HELA_Human1.13550329
63ERG_20517297_ChIP-Seq_VCAP_Human1.13262850
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12330024
65CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.12236612
66PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.12085973
67TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.08690428
68FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.08687669
69FOXA1_25329375_ChIP-Seq_VCAP_Human1.08480843
70FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08480843
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08266203
72EED_16625203_ChIP-ChIP_MESCs_Mouse1.07390674
73E2F1_18555785_ChIP-Seq_MESCs_Mouse1.05307938
74GATA1_22025678_ChIP-Seq_K562_Human1.04689443
75PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.03430635
76IRF8_21731497_ChIP-ChIP_J774_Mouse1.03414332
77EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.02892151
78FUS_26573619_Chip-Seq_HEK293_Human1.02766997
79GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.02580032
80FLI1_27457419_Chip-Seq_LIVER_Mouse1.00725229
81HTT_18923047_ChIP-ChIP_STHdh_Human1.00596727
82GATA3_26560356_Chip-Seq_TH2_Human0.99227931
83FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98331370
84HOXB4_20404135_ChIP-ChIP_EML_Mouse0.96653685
85SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96381085
86PCGF2_27294783_Chip-Seq_ESCs_Mouse0.95971889
87E2F4_17652178_ChIP-ChIP_JURKAT_Human0.94455630
88STAT1_20625510_ChIP-Seq_HELA_Human0.93758103
89AUTS2_25519132_ChIP-Seq_293T-REX_Human0.93435653
90FOXA1_21572438_ChIP-Seq_LNCaP_Human0.92458665
91CBX2_27304074_Chip-Seq_ESCs_Mouse0.92071733
92NANOG_20526341_ChIP-Seq_ESCs_Human0.91323173
93KLF5_20875108_ChIP-Seq_MESCs_Mouse0.91046625
94P53_21459846_ChIP-Seq_SAOS-2_Human0.90339669
95CTBP1_25329375_ChIP-Seq_LNCAP_Human0.90089455
96POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.89076806
97RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.88595820
98ELF5_23300383_ChIP-Seq_T47D_Human0.87598463
99TCF4_22108803_ChIP-Seq_LS180_Human0.86611253
100ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.85858321

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.01255512
2MP0002277_abnormal_respiratory_mucosa4.37674807
3MP0000372_irregular_coat_pigmentation3.25242961
4MP0002138_abnormal_hepatobiliary_system3.18020823
5MP0002876_abnormal_thyroid_physiology3.14653926
6MP0003136_yellow_coat_color3.05763133
7MP0002163_abnormal_gland_morphology3.05399186
8MP0006292_abnormal_olfactory_placode2.80627471
9MP0005360_urolithiasis2.77768545
10MP0008875_abnormal_xenobiotic_pharmacok2.62934977
11MP0003567_abnormal_fetal_cardiomyocyte2.51483872
12MP0003183_abnormal_peptide_metabolism2.50956379
13MP0001188_hyperpigmentation2.43184155
14MP0003806_abnormal_nucleotide_metabolis2.40647494
15MP0001835_abnormal_antigen_presentation1.97187677
16MP0003786_premature_aging1.95365704
17MP0002132_abnormal_respiratory_system1.89992101
18MP0008872_abnormal_physiological_respon1.89816804
19MP0003186_abnormal_redox_activity1.85465794
20MP0005645_abnormal_hypothalamus_physiol1.77192913
21MP0000049_abnormal_middle_ear1.67632355
22MP0003693_abnormal_embryo_hatching1.65150070
23MP0001873_stomach_inflammation1.57542470
24MP0002095_abnormal_skin_pigmentation1.57125023
25MP0005085_abnormal_gallbladder_physiolo1.54002733
26MP0004142_abnormal_muscle_tone1.53022480
27MP0008058_abnormal_DNA_repair1.48409655
28MP0008995_early_reproductive_senescence1.47410555
29MP0003195_calcinosis1.46874910
30MP0005379_endocrine/exocrine_gland_phen1.46402848
31MP0003646_muscle_fatigue1.42196909
32MP0000631_abnormal_neuroendocrine_gland1.42003182
33MP0001293_anophthalmia1.39977764
34MP0005174_abnormal_tail_pigmentation1.38581109
35MP0004885_abnormal_endolymph1.38231505
36MP0005646_abnormal_pituitary_gland1.35528378
37MP0006072_abnormal_retinal_apoptosis1.33973012
38MP0002139_abnormal_hepatobiliary_system1.31198394
39MP0004381_abnormal_hair_follicle1.30955069
40MP0005187_abnormal_penis_morphology1.30617415
41MP0001485_abnormal_pinna_reflex1.30454434
42MP0005332_abnormal_amino_acid1.29182461
43MP0005377_hearing/vestibular/ear_phenot1.28221452
44MP0003878_abnormal_ear_physiology1.28221452
45MP0004742_abnormal_vestibular_system1.26561797
46MP0000685_abnormal_immune_system1.22742016
47MP0005671_abnormal_response_to1.22270768
48MP0004484_altered_response_of1.22247532
49MP0005075_abnormal_melanosome_morpholog1.16947718
50MP0005083_abnormal_biliary_tract1.16639621
51MP0009785_altered_susceptibility_to1.16495653
52MP0003718_maternal_effect1.15429663
53MP0003724_increased_susceptibility_to1.14456986
54MP0000678_abnormal_parathyroid_gland1.04183703
55MP0008789_abnormal_olfactory_epithelium1.03005960
56MP0005084_abnormal_gallbladder_morpholo1.02254300
57MP0006082_CNS_inflammation1.00122716
58MP0002938_white_spotting0.99971283
59MP0004957_abnormal_blastocyst_morpholog0.99144829
60MP0005636_abnormal_mineral_homeostasis0.96253730
61MP0000490_abnormal_crypts_of0.94275545
62MP0001529_abnormal_vocalization0.94256541
63MP0001800_abnormal_humoral_immune0.91916402
64MP0001968_abnormal_touch/_nociception0.91483715
65MP0005387_immune_system_phenotype0.88415744
66MP0001790_abnormal_immune_system0.88415744
67MP0002653_abnormal_ependyma_morphology0.86554859
68MP0004145_abnormal_muscle_electrophysio0.85081831
69MP0008877_abnormal_DNA_methylation0.85074848
70MP0002148_abnormal_hypersensitivity_rea0.84165414
71MP0001764_abnormal_homeostasis0.82271871
72MP0002254_reproductive_system_inflammat0.80389589
73MP0000566_synostosis0.79574689
74MP0004147_increased_porphyrin_level0.77679478
75MP0009764_decreased_sensitivity_to0.76417608
76MP0009697_abnormal_copulation0.75780066
77MP0005503_abnormal_tendon_morphology0.75119497
78MP0000383_abnormal_hair_follicle0.74807070
79MP0003656_abnormal_erythrocyte_physiolo0.74260911
80MP0003938_abnormal_ear_development0.67418483
81MP0001440_abnormal_grooming_behavior0.67294425
82MP0002234_abnormal_pharynx_morphology0.66925532
83MP0009765_abnormal_xenobiotic_induced0.66350430
84MP0003011_delayed_dark_adaptation0.66289589
85MP0008775_abnormal_heart_ventricle0.65139205
86MP0003077_abnormal_cell_cycle0.65040226
87MP0002723_abnormal_immune_serum0.64682844
88MP0010155_abnormal_intestine_physiology0.63713282
89MP0003123_paternal_imprinting0.60379936
90MP0002272_abnormal_nervous_system0.59924777
91MP0000613_abnormal_salivary_gland0.58554780
92MP0001663_abnormal_digestive_system0.58118699
93MP0005386_behavior/neurological_phenoty0.57100785
94MP0004924_abnormal_behavior0.57100785
95MP0003866_abnormal_defecation0.55751610
96MP0001186_pigmentation_phenotype0.54366929
97MP0005410_abnormal_fertilization0.53710754
98MP0002160_abnormal_reproductive_system0.53015380
99MP0005389_reproductive_system_phenotype0.52880527
100MP0005000_abnormal_immune_tolerance0.52123281

Predicted human phenotypes

RankGene SetZ-score
1Lipid accumulation in hepatocytes (HP:0006561)4.34807460
2Increased hepatocellular lipid droplets (HP:0006565)4.23811726
3Respiratory difficulties (HP:0002880)4.00339299
4Stomatitis (HP:0010280)3.98240120
5Abnormality of alanine metabolism (HP:0010916)3.90439868
6Hyperalaninemia (HP:0003348)3.90439868
7Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.90439868
8Abnormal hemoglobin (HP:0011902)3.76454366
9Increased intramyocellular lipid droplets (HP:0012240)3.61282259
10Abnormality of cells of the erythroid lineage (HP:0012130)3.50483814
11Acute necrotizing encephalopathy (HP:0006965)3.48978329
12Increased muscle lipid content (HP:0009058)3.41975583
13Mitochondrial inheritance (HP:0001427)3.40199830
14Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.38640806
15Degeneration of the lateral corticospinal tracts (HP:0002314)3.38640806
16Hypoplasia of the uterus (HP:0000013)3.36714589
17Renal Fanconi syndrome (HP:0001994)3.36490295
18Acute encephalopathy (HP:0006846)3.31820042
19Glycosuria (HP:0003076)3.24172898
20Abnormality of urine glucose concentration (HP:0011016)3.24172898
21Increased CSF lactate (HP:0002490)3.17389642
22Abnormal mitochondria in muscle tissue (HP:0008316)3.15869041
23Carpal bone hypoplasia (HP:0001498)3.01886664
24Reticulocytopenia (HP:0001896)2.92065966
25Pallor (HP:0000980)2.89287808
26Aplasia/hypoplasia of the uterus (HP:0008684)2.88830955
27Macrocytic anemia (HP:0001972)2.86894135
28Microretrognathia (HP:0000308)2.80056638
29Exertional dyspnea (HP:0002875)2.79105888
30Progressive macrocephaly (HP:0004481)2.78012833
31Hyperglycinemia (HP:0002154)2.76674325
32Septo-optic dysplasia (HP:0100842)2.74473914
33Partial duplication of thumb phalanx (HP:0009944)2.71114443
34Absent rod-and cone-mediated responses on ERG (HP:0007688)2.70101331
35Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.66797123
363-Methylglutaconic aciduria (HP:0003535)2.63639686
37Abnormal number of erythroid precursors (HP:0012131)2.62759618
38Confusion (HP:0001289)2.58728088
39Cerebral edema (HP:0002181)2.54986360
40Abnormal pupillary function (HP:0007686)2.52158515
41Abnormality of glycolysis (HP:0004366)2.48197316
42Increased serum lactate (HP:0002151)2.46827095
43Abnormality of the heme biosynthetic pathway (HP:0010472)2.44376728
44Lethargy (HP:0001254)2.42056941
45Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.40803430
46Reduced antithrombin III activity (HP:0001976)2.39099212
47Hyperphosphaturia (HP:0003109)2.38559150
48Increased IgM level (HP:0003496)2.32650098
49Abnormality of serum amino acid levels (HP:0003112)2.31809984
50Abnormality of the corticospinal tract (HP:0002492)2.29784999
51Hepatocellular necrosis (HP:0001404)2.22312313
52Hepatic necrosis (HP:0002605)2.20782838
53Partial duplication of the phalanx of hand (HP:0009999)2.18474480
54Decreased activity of mitochondrial respiratory chain (HP:0008972)2.15663143
55Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.15663143
56Lactic acidosis (HP:0003128)2.14663256
57Flat capital femoral epiphysis (HP:0003370)2.13790171
58Glioma (HP:0009733)2.13016867
59Methylmalonic acidemia (HP:0002912)2.06074506
60Abnormality of the diencephalon (HP:0010662)2.05830771
61Fibular aplasia (HP:0002990)2.05672719
62Polycythemia (HP:0001901)2.05509508
63Abnormal rod and cone electroretinograms (HP:0008323)2.01984334
64Stenosis of the external auditory canal (HP:0000402)2.01187595
65Decreased central vision (HP:0007663)2.00710042
66Optic disc pallor (HP:0000543)1.97833046
67Elevated erythrocyte sedimentation rate (HP:0003565)1.97039937
68Abnormality of the nasal septum (HP:0000419)1.95884109
69Renal tubular dysfunction (HP:0000124)1.92837766
70Impulsivity (HP:0100710)1.90968841
71Humeroradial synostosis (HP:0003041)1.89267325
72Synostosis involving the elbow (HP:0003938)1.89267325
73Maternal diabetes (HP:0009800)1.88934007
74Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.86657391
75Down-sloping shoulders (HP:0200021)1.85749497
76Abnormality of renal resorption (HP:0011038)1.85113429
77Supernumerary bones of the axial skeleton (HP:0009144)1.83778444
78Focal motor seizures (HP:0011153)1.83297350
79Concave nail (HP:0001598)1.81051692
80Cholecystitis (HP:0001082)1.79771629
81Abnormal gallbladder physiology (HP:0012438)1.79771629
82Delayed CNS myelination (HP:0002188)1.79595668
83Pendular nystagmus (HP:0012043)1.79372448
84Neurodegeneration (HP:0002180)1.78594911
85Patent foramen ovale (HP:0001655)1.77830848
86Onycholysis (HP:0001806)1.77830530
87True hermaphroditism (HP:0010459)1.77277851
88Thickened helices (HP:0000391)1.73379089
89Symphalangism affecting the phalanges of the hand (HP:0009773)1.73333537
90Leukodystrophy (HP:0002415)1.69390469
91Absent septum pellucidum (HP:0001331)1.69048158
92Abnormal protein glycosylation (HP:0012346)1.68571953
93Abnormal glycosylation (HP:0012345)1.68571953
94Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.68571953
95Abnormal protein N-linked glycosylation (HP:0012347)1.68571953
96Recurrent bacterial skin infections (HP:0005406)1.67040008
97Abnormal urine phosphate concentration (HP:0012599)1.66564433
98Microcytic anemia (HP:0001935)1.64480115
99Hyperammonemia (HP:0001987)1.62655574
100Hypochromic anemia (HP:0001931)1.62643364

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR4.82784554
2PBK4.48421761
3MAP4K24.31409699
4AKT33.60916695
5TAOK33.52788133
6BCKDK3.08857134
7PLK42.71728511
8NME22.69679537
9TXK2.44920245
10ZAK2.44789888
11PDK22.29718621
12BRAF1.83215835
13RPS6KA41.68777601
14STK38L1.61218916
15DYRK21.46914685
16CASK1.46025525
17ADRBK21.45299361
18GRK11.44552587
19FLT31.36068038
20IRAK41.34037526
21TIE11.24678874
22WNK41.23785541
23MST41.22041948
24NEK11.12920893
25MKNK11.12346242
26DYRK31.11712948
27NUAK11.09510227
28STK241.09495105
29LRRK21.06601315
30MATK0.98214237
31EPHA30.95877930
32TNK20.95292214
33ADRBK10.92052921
34RPS6KA50.92044123
35LATS10.87840459
36PIK3CA0.87077321
37CDK30.87062235
38TSSK60.86651035
39IKBKB0.85539517
40ARAF0.85485685
41GRK70.84730541
42PKN20.80581980
43FRK0.78804737
44IKBKE0.76479423
45SRPK10.75648198
46MKNK20.73063356
47STK40.72544818
48GRK50.71985568
49SGK20.70740278
50DAPK20.68639004
51MOS0.66557720
52STK390.63527166
53EPHA40.62145535
54PRKCQ0.61983558
55RPS6KA60.61178586
56MAP2K20.60263437
57SGK4940.60237458
58SGK2230.60237458
59STK30.60169165
60PRKD30.60085029
61MAP2K60.59304323
62AURKB0.56468989
63IRAK10.54264012
64MAP4K10.53863103
65PASK0.52854759
66SGK30.51648395
67BMPR1B0.51483795
68MAP2K30.51275459
69OXSR10.50991331
70RPS6KA10.49532610
71TNIK0.49265442
72PINK10.49090387
73RPS6KC10.48024671
74RPS6KL10.48024671
75PIM10.47926660
76CSNK2A20.46479013
77TGFBR10.46183506
78VRK10.44023248
79NEK60.43545782
80PLK30.43329501
81PLK20.42887604
82PRKG10.42606166
83ZAP700.42598785
84TGFBR20.42227455
85TEC0.40906214
86LYN0.39277482
87PHKG10.38548270
88PHKG20.38548270
89CDK190.37806210
90WNK30.35804004
91PAK30.34859113
92CSNK2A10.34272488
93MAP3K80.34103145
94MAPK70.33811647
95CAMK10.33717077
96PIK3CG0.33349887
97GRK60.32856548
98BMPR20.31871061
99NME10.31564627
100AURKA0.31547177

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.37640043
2Oxidative phosphorylation_Homo sapiens_hsa001903.93060718
3Parkinsons disease_Homo sapiens_hsa050123.38784825
4Proteasome_Homo sapiens_hsa030502.18392301
5RNA polymerase_Homo sapiens_hsa030202.18222564
6RNA degradation_Homo sapiens_hsa030182.18108980
7Huntingtons disease_Homo sapiens_hsa050162.11009645
8Basal transcription factors_Homo sapiens_hsa030222.03248363
9Alzheimers disease_Homo sapiens_hsa050102.02217988
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.02117468
11Asthma_Homo sapiens_hsa053101.98843087
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.93643860
13Retinol metabolism_Homo sapiens_hsa008301.87040267
14Linoleic acid metabolism_Homo sapiens_hsa005911.79706847
15Protein export_Homo sapiens_hsa030601.78767309
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.69976639
17Cyanoamino acid metabolism_Homo sapiens_hsa004601.66849361
18Propanoate metabolism_Homo sapiens_hsa006401.65814426
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.64452142
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.64447867
21Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.62380707
22Peroxisome_Homo sapiens_hsa041461.60158714
23Sulfur metabolism_Homo sapiens_hsa009201.58480993
24Sulfur relay system_Homo sapiens_hsa041221.57684756
25Homologous recombination_Homo sapiens_hsa034401.55050143
26Cardiac muscle contraction_Homo sapiens_hsa042601.54830983
27One carbon pool by folate_Homo sapiens_hsa006701.43240678
28Pyruvate metabolism_Homo sapiens_hsa006201.36199905
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.32055871
30Pyrimidine metabolism_Homo sapiens_hsa002401.30530913
31Allograft rejection_Homo sapiens_hsa053301.30289657
32Butanoate metabolism_Homo sapiens_hsa006501.28753618
33Fat digestion and absorption_Homo sapiens_hsa049751.24067981
34Autoimmune thyroid disease_Homo sapiens_hsa053201.21665269
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.19281541
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.18337057
37Spliceosome_Homo sapiens_hsa030401.17475198
38Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.16615630
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.15676207
40DNA replication_Homo sapiens_hsa030301.15266027
41Chemical carcinogenesis_Homo sapiens_hsa052041.14653740
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.12678778
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.11472271
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.05630546
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.05317307
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05096665
47Arachidonic acid metabolism_Homo sapiens_hsa005901.05018406
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.98895059
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.98635315
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.98338398
51Primary immunodeficiency_Homo sapiens_hsa053400.94708113
52Primary bile acid biosynthesis_Homo sapiens_hsa001200.93126165
53Ether lipid metabolism_Homo sapiens_hsa005650.90256701
54Metabolic pathways_Homo sapiens_hsa011000.85575441
55Pentose and glucuronate interconversions_Homo sapiens_hsa000400.84690187
56RNA transport_Homo sapiens_hsa030130.82570353
57Folate biosynthesis_Homo sapiens_hsa007900.81016900
58Nucleotide excision repair_Homo sapiens_hsa034200.80855853
59Vitamin digestion and absorption_Homo sapiens_hsa049770.80219475
60beta-Alanine metabolism_Homo sapiens_hsa004100.79301103
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79232218
62Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.78875720
63Purine metabolism_Homo sapiens_hsa002300.75327236
64Fatty acid elongation_Homo sapiens_hsa000620.75193599
65Nitrogen metabolism_Homo sapiens_hsa009100.74901764
66Tryptophan metabolism_Homo sapiens_hsa003800.70534425
67Malaria_Homo sapiens_hsa051440.67277645
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.66022526
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65979700
70Rheumatoid arthritis_Homo sapiens_hsa053230.62154915
71Renin-angiotensin system_Homo sapiens_hsa046140.62060762
72Mismatch repair_Homo sapiens_hsa034300.61274444
73Arginine biosynthesis_Homo sapiens_hsa002200.59181292
74Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58596009
75Fanconi anemia pathway_Homo sapiens_hsa034600.57720014
76Arginine and proline metabolism_Homo sapiens_hsa003300.57015461
77Caffeine metabolism_Homo sapiens_hsa002320.55974449
78Phenylalanine metabolism_Homo sapiens_hsa003600.55638838
79Starch and sucrose metabolism_Homo sapiens_hsa005000.47462114
80Collecting duct acid secretion_Homo sapiens_hsa049660.46840948
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44144958
82Maturity onset diabetes of the young_Homo sapiens_hsa049500.42703825
83Fatty acid degradation_Homo sapiens_hsa000710.42388358
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.37580619
85Basal cell carcinoma_Homo sapiens_hsa052170.35210662
86Antigen processing and presentation_Homo sapiens_hsa046120.31780097
87NOD-like receptor signaling pathway_Homo sapiens_hsa046210.29883345
88T cell receptor signaling pathway_Homo sapiens_hsa046600.29205718
89Histidine metabolism_Homo sapiens_hsa003400.29092869
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.25650989
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25181560
92Glutathione metabolism_Homo sapiens_hsa004800.24981472
93Systemic lupus erythematosus_Homo sapiens_hsa053220.22953717
94Phototransduction_Homo sapiens_hsa047440.22573697
95Hematopoietic cell lineage_Homo sapiens_hsa046400.22330898
96Graft-versus-host disease_Homo sapiens_hsa053320.20905399
97Base excision repair_Homo sapiens_hsa034100.18408008
98Bile secretion_Homo sapiens_hsa049760.17187693
99Mineral absorption_Homo sapiens_hsa049780.16591423
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.12815993

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