ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	proteasome assembly (GO:0043248)	5.95384203
2	response to pheromone (GO:0019236)	5.87428435
3	cell wall macromolecule catabolic process (GO:0016998)	5.20428636
4	respiratory chain complex IV assembly (GO:0008535)	4.75244261
5	cytochrome complex assembly (GO:0017004)	4.61855842
6	retinal rod cell development (GO:0046548)	4.51395124
7	cell wall macromolecule metabolic process (GO:0044036)	4.50293241
8	regulation of DNA endoreduplication (GO:0032875)	4.17597066
9	water-soluble vitamin biosynthetic process (GO:0042364)	4.07128681
10	protein prenylation (GO:0018342)	3.97092207
11	prenylation (GO:0097354)	3.97092207
12	replication fork processing (GO:0031297)	3.96984303
13	base-excision repair, AP site formation (GO:0006285)	3.90545709
14	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.80092979
15	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	3.78824080
16	mitotic sister chromatid cohesion (GO:0007064)	3.74404708
17	xenobiotic catabolic process (GO:0042178)	3.73031674
18	inner ear receptor stereocilium organization (GO:0060122)	3.72255118
19	termination of RNA polymerase III transcription (GO:0006386)	3.66418237
20	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.66418237
21	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.66028165
22	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.60036616
23	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	3.54209563
24	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	3.54209563
25	isotype switching (GO:0045190)	3.54209563
26	pseudouridine synthesis (GO:0001522)	3.54084017
27	maturation of 5.8S rRNA (GO:0000460)	3.50858613
28	DNA replication checkpoint (GO:0000076)	3.49431632
29	rRNA modification (GO:0000154)	3.48407799
30	cullin deneddylation (GO:0010388)	3.47889360
31	somatic diversification of immunoglobulins (GO:0016445)	3.41402101
32	platelet dense granule organization (GO:0060155)	3.41278877
33	protein K11-linked deubiquitination (GO:0035871)	3.38569605
34	histone H2A acetylation (GO:0043968)	3.37658981
35	protein deneddylation (GO:0000338)	3.36825502
36	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.27390433
37	otic vesicle formation (GO:0030916)	3.25013192
38	negative regulation of keratinocyte proliferation (GO:0010839)	3.20663299
39	ncRNA catabolic process (GO:0034661)	3.13054258
40	synapsis (GO:0007129)	3.12659736
41	motile cilium assembly (GO:0044458)	3.10966685
42	transcription elongation from RNA polymerase I promoter (GO:0006362)	3.06153481
43	centriole replication (GO:0007099)	3.05333636
44	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.03711426
45	regulation of glucokinase activity (GO:0033131)	3.00192941
46	regulation of hexokinase activity (GO:1903299)	3.00192941
47	regulation of immunoglobulin secretion (GO:0051023)	2.98492769
48	DNA replication-dependent nucleosome assembly (GO:0006335)	2.97846341
49	DNA replication-dependent nucleosome organization (GO:0034723)	2.97846341
50	regulation of cellular amino acid metabolic process (GO:0006521)	2.93791359
51	regulation of mitotic spindle checkpoint (GO:1903504)	2.91126361
52	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.91126361
53	protein complex biogenesis (GO:0070271)	2.88131883
54	histone H2A ubiquitination (GO:0033522)	2.87518934
55	UTP biosynthetic process (GO:0006228)	2.85686769
56	DNA deamination (GO:0045006)	2.84072732
57	meiotic chromosome segregation (GO:0045132)	2.79975043
58	regulation of mitochondrial translation (GO:0070129)	2.79210468
59	GTP biosynthetic process (GO:0006183)	2.78955653
60	blastocyst development (GO:0001824)	2.74419306
61	histone exchange (GO:0043486)	2.73819888
62	nonmotile primary cilium assembly (GO:0035058)	2.73717553
63	viral mRNA export from host cell nucleus (GO:0046784)	2.73411735
64	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.72080638
65	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.72080638
66	NADH dehydrogenase complex assembly (GO:0010257)	2.72080638
67	rRNA catabolic process (GO:0016075)	2.70250061
68	ribosome biogenesis (GO:0042254)	2.69731033
69	somatic diversification of immune receptors (GO:0002200)	2.69147309
70	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.68426611
71	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.67591782
72	termination of RNA polymerase I transcription (GO:0006363)	2.66228217
73	somatic recombination of immunoglobulin gene segments (GO:0016447)	2.64947244
74	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.64890905
75	cellular ketone body metabolic process (GO:0046950)	2.64588762
76	transcription initiation from RNA polymerase I promoter (GO:0006361)	2.63599287
77	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.62941077
78	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.62548184
79	UTP metabolic process (GO:0046051)	2.62111131
80	kinetochore organization (GO:0051383)	2.60539188
81	phenylpropanoid metabolic process (GO:0009698)	2.60109160
82	double-strand break repair via homologous recombination (GO:0000724)	2.59237364
83	double-strand break repair via nonhomologous end joining (GO:0006303)	2.59033485
84	non-recombinational repair (GO:0000726)	2.59033485
85	transcription from RNA polymerase III promoter (GO:0006383)	2.58848018
86	keratan sulfate catabolic process (GO:0042340)	2.58844291
87	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.58805618
88	telomere maintenance via telomerase (GO:0007004)	2.58408600
89	mitochondrial respiratory chain complex assembly (GO:0033108)	2.58388677
90	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.56427928
91	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.56427928
92	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.56427928
93	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.55984067
94	sister chromatid cohesion (GO:0007062)	2.55933410
95	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.55730289
96	DNA double-strand break processing (GO:0000729)	2.55269925
97	male meiosis I (GO:0007141)	2.55130459
98	forebrain neuron differentiation (GO:0021879)	2.54360787
99	negative regulation of mast cell activation (GO:0033004)	2.53815898
100	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.52982447

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.35587832
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.98397430
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.51249368
4	VDR_22108803_ChIP-Seq_LS180_Human	3.36935785
5	ELK1_19687146_ChIP-ChIP_HELA_Human	3.21620910
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.12615028
7	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.77770372
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.76005538
9	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.73452699
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.69122075
11	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.64896715
12	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.35307029
13	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.09902943
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.03920596
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.00483456
16	E2F7_22180533_ChIP-Seq_HELA_Human	1.97278553
17	EWS_26573619_Chip-Seq_HEK293_Human	1.94723393
18	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.90795505
19	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.88227921
20	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.87439061
21	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.85740988
22	FUS_26573619_Chip-Seq_HEK293_Human	1.84274187
23	P300_19829295_ChIP-Seq_ESCs_Human	1.73839654
24	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.72299615
25	BCAT_22108803_ChIP-Seq_LS180_Human	1.71804172
26	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.71118400
27	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.66588120
28	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.64219705
29	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.62700123
30	ER_23166858_ChIP-Seq_MCF-7_Human	1.59475120
31	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.56495748
32	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.56495748
33	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.51708911
34	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.48937151
35	HTT_18923047_ChIP-ChIP_STHdh_Human	1.45198645
36	CBP_20019798_ChIP-Seq_JUKART_Human	1.42547527
37	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.42547527
38	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.41284129
39	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.40933866
40	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.39448960
41	FOXP3_21729870_ChIP-Seq_TREG_Human	1.39270867
42	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.36317259
43	MYC_18940864_ChIP-ChIP_HL60_Human	1.35818635
44	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.34019822
45	IGF1R_20145208_ChIP-Seq_DFB_Human	1.34010431
46	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.33393742
47	TCF4_22108803_ChIP-Seq_LS180_Human	1.32684851
48	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.29619528
49	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.26137750
50	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.25274259
51	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.23681648
52	TAF15_26573619_Chip-Seq_HEK293_Human	1.23318551
53	GABP_19822575_ChIP-Seq_HepG2_Human	1.22397921
54	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.22103682
55	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.19283202
56	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.19129952
57	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.17711803
58	TP53_22573176_ChIP-Seq_HFKS_Human	1.17210255
59	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.17157550
60	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.15464627
61	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.15012593
62	DCP1A_22483619_ChIP-Seq_HELA_Human	1.14720825
63	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.14222360
64	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.14199061
65	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.13344710
66	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.13223915
67	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.13124203
68	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.12699186
69	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.12484269
70	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.12223962
71	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.11683722
72	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.11683722
73	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.08471186
74	TTF2_22483619_ChIP-Seq_HELA_Human	1.07958054
75	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	1.07543775
76	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.06227595
77	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.05481991
78	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.05012407
79	GBX2_23144817_ChIP-Seq_PC3_Human	1.04753571
80	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.03970878
81	STAT3_23295773_ChIP-Seq_U87_Human	1.03951937
82	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.01755857
83	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.00724775
84	SMAD4_21799915_ChIP-Seq_A2780_Human	1.00699720
85	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.00637460
86	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.00094236
87	PHF8_20622853_ChIP-Seq_HELA_Human	0.99753245
88	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	0.98547636
89	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.98089141
90	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.97858131
91	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.96953056
92	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.96553881
93	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.96021825
94	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.95911491
95	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.95731455
96	CDX2_22108803_ChIP-Seq_LS180_Human	0.94982809
97	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.94750503
98	TCF4_23295773_ChIP-Seq_U87_Human	0.94685811
99	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.94681251
100	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.94471076

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004147_increased_porphyrin_level	3.51929780
2	MP0002089_abnormal_postnatal_growth/wei	3.35261237
3	MP0008877_abnormal_DNA_methylation	3.00384825
4	MP0006292_abnormal_olfactory_placode	2.95229773
5	MP0003693_abnormal_embryo_hatching	2.84157430
6	MP0003136_yellow_coat_color	2.81884159
7	MP0002102_abnormal_ear_morphology	2.69977573
8	MP0003195_calcinosis	2.55768397
9	MP0010094_abnormal_chromosome_stability	2.50001748
10	MP0008789_abnormal_olfactory_epithelium	2.39175674
11	MP0008872_abnormal_physiological_respon	2.35357281
12	MP0003787_abnormal_imprinting	2.28391990
13	MP0002132_abnormal_respiratory_system	2.26716362
14	MP0001986_abnormal_taste_sensitivity	2.17828615
15	MP0005171_absent_coat_pigmentation	2.12445841
16	MP0000372_irregular_coat_pigmentation	2.07312387
17	MP0008058_abnormal_DNA_repair	2.04720009
18	MP0009697_abnormal_copulation	2.04209938
19	MP0003718_maternal_effect	1.99031996
20	MP0001661_extended_life_span	1.97797266
21	MP0005670_abnormal_white_adipose	1.85526775
22	MP0003646_muscle_fatigue	1.81995896
23	MP0002277_abnormal_respiratory_mucosa	1.67541879
24	MP0003950_abnormal_plasma_membrane	1.67181652
25	MP0002736_abnormal_nociception_after	1.62534922
26	MP0001485_abnormal_pinna_reflex	1.59943158
27	MP0003111_abnormal_nucleus_morphology	1.58746944
28	MP0004957_abnormal_blastocyst_morpholog	1.54328864
29	MP0001968_abnormal_touch/_nociception	1.52442445
30	MP0005551_abnormal_eye_electrophysiolog	1.50384012
31	MP0000427_abnormal_hair_cycle	1.49580910
32	MP0005410_abnormal_fertilization	1.45840216
33	MP0004885_abnormal_endolymph	1.44893308
34	MP0001764_abnormal_homeostasis	1.44719949
35	MP0003183_abnormal_peptide_metabolism	1.41912145
36	MP0001529_abnormal_vocalization	1.41513058
37	MP0000631_abnormal_neuroendocrine_gland	1.35152536
38	MP0008875_abnormal_xenobiotic_pharmacok	1.28785988
39	MP0005084_abnormal_gallbladder_morpholo	1.26403667
40	MP0005395_other_phenotype	1.25258818
41	MP0002653_abnormal_ependyma_morphology	1.24340124
42	MP0001293_anophthalmia	1.23572888
43	MP0003938_abnormal_ear_development	1.21843338
44	MP0002876_abnormal_thyroid_physiology	1.18802397
45	MP0005394_taste/olfaction_phenotype	1.16994976
46	MP0005499_abnormal_olfactory_system	1.16994976
47	MP0004133_heterotaxia	1.12787124
48	MP0002938_white_spotting	1.11346872
49	MP0003786_premature_aging	1.10396695
50	MP0001697_abnormal_embryo_size	1.09289621
51	MP0000647_abnormal_sebaceous_gland	1.06494019
52	MP0001929_abnormal_gametogenesis	1.06394481
53	MP0005360_urolithiasis	1.05819179
54	MP0002254_reproductive_system_inflammat	1.02942275
55	MP0002638_abnormal_pupillary_reflex	1.00855460
56	MP0001984_abnormal_olfaction	1.00822391
57	MP0002233_abnormal_nose_morphology	1.00290797
58	MP0005365_abnormal_bile_salt	0.99410531
59	MP0004742_abnormal_vestibular_system	0.98805789
60	MP0005174_abnormal_tail_pigmentation	0.96531337
61	MP0004215_abnormal_myocardial_fiber	0.95798212
62	MP0003011_delayed_dark_adaptation	0.95369521
63	MP0001286_abnormal_eye_development	0.93285523
64	MP0002090_abnormal_vision	0.93105793
65	MP0005636_abnormal_mineral_homeostasis	0.92729820
66	MP0006036_abnormal_mitochondrial_physio	0.91423857
67	MP0005253_abnormal_eye_physiology	0.91219582
68	MP0009046_muscle_twitch	0.90811675
69	MP0002168_other_aberrant_phenotype	0.88288356
70	MP0003119_abnormal_digestive_system	0.87488154
71	MP0002234_abnormal_pharynx_morphology	0.86793201
72	MP0000026_abnormal_inner_ear	0.86661773
73	MP0003880_abnormal_central_pattern	0.84867277
74	MP0003121_genomic_imprinting	0.84354062
75	MP0001119_abnormal_female_reproductive	0.83985142
76	MP0000049_abnormal_middle_ear	0.83391682
77	MP0008932_abnormal_embryonic_tissue	0.83245131
78	MP0001501_abnormal_sleep_pattern	0.82431243
79	MP0009780_abnormal_chondrocyte_physiolo	0.82171109
80	MP0003698_abnormal_male_reproductive	0.81822838
81	MP0002282_abnormal_trachea_morphology	0.81009372
82	MP0003755_abnormal_palate_morphology	0.78540474
83	MP0001727_abnormal_embryo_implantation	0.77522189
84	MP0003077_abnormal_cell_cycle	0.77338311
85	MP0002734_abnormal_mechanical_nocicepti	0.76916633
86	MP0006072_abnormal_retinal_apoptosis	0.75586763
87	MP0002210_abnormal_sex_determination	0.74703128
88	MP0001963_abnormal_hearing_physiology	0.74251086
89	MP0003936_abnormal_reproductive_system	0.73621399
90	MP0004142_abnormal_muscle_tone	0.72725179
91	MP0003937_abnormal_limbs/digits/tail_de	0.72645965
92	MP0005195_abnormal_posterior_eye	0.72533168
93	MP0004134_abnormal_chest_morphology	0.71918324
94	MP0002095_abnormal_skin_pigmentation	0.71314798
95	MP0004484_altered_response_of	0.70733370
96	MP0002139_abnormal_hepatobiliary_system	0.70298193
97	MP0005085_abnormal_gallbladder_physiolo	0.69743808
98	MP0000778_abnormal_nervous_system	0.69209509
99	MP0002928_abnormal_bile_duct	0.68793035
100	MP0001324_abnormal_eye_pigmentation	0.68423833

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	4.22182066
2	Increased hepatocellular lipid droplets (HP:0006565)	3.75168124
3	Volvulus (HP:0002580)	3.50940126
4	Increased CSF lactate (HP:0002490)	3.50209669
5	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.37080835
6	Abnormality of alanine metabolism (HP:0010916)	3.37080835
7	Hyperalaninemia (HP:0003348)	3.37080835
8	Acanthocytosis (HP:0001927)	3.31929618
9	Lipid accumulation in hepatocytes (HP:0006561)	3.31676972
10	Hepatocellular necrosis (HP:0001404)	3.22887805
11	Mitochondrial inheritance (HP:0001427)	3.14442184
12	Pancreatic cysts (HP:0001737)	3.09787965
13	Acute necrotizing encephalopathy (HP:0006965)	3.06840236
14	True hermaphroditism (HP:0010459)	2.99054447
15	Absent/shortened dynein arms (HP:0200106)	2.97209575
16	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.97209575
17	Acute encephalopathy (HP:0006846)	2.93942033
18	Hyperglycinemia (HP:0002154)	2.81279320
19	Renal Fanconi syndrome (HP:0001994)	2.77623242
20	Progressive macrocephaly (HP:0004481)	2.70080037
21	Respiratory difficulties (HP:0002880)	2.67840622
22	Type I transferrin isoform profile (HP:0003642)	2.58974411
23	Abnormality of midbrain morphology (HP:0002418)	2.58411862
24	Molar tooth sign on MRI (HP:0002419)	2.58411862
25	Hepatic necrosis (HP:0002605)	2.57790101
26	Hypothermia (HP:0002045)	2.50563102
27	Abnormal number of erythroid precursors (HP:0012131)	2.49932233
28	Poikilocytosis (HP:0004447)	2.48633195
29	Abnormal mitochondria in muscle tissue (HP:0008316)	2.46782173
30	Increased IgM level (HP:0003496)	2.45903725
31	Brushfield spots (HP:0001088)	2.45887172
32	Abnormal respiratory motile cilium physiology (HP:0012261)	2.44050566
33	Hypomagnesemia (HP:0002917)	2.41076340
34	Medial flaring of the eyebrow (HP:0010747)	2.37980382
35	Reduced antithrombin III activity (HP:0001976)	2.36743219
36	Chronic bronchitis (HP:0004469)	2.34131509
37	Increased serum lactate (HP:0002151)	2.33800858
38	Exertional dyspnea (HP:0002875)	2.33615446
39	Pancreatic fibrosis (HP:0100732)	2.32526427
40	Septo-optic dysplasia (HP:0100842)	2.27838828
41	Sclerocornea (HP:0000647)	2.26309632
42	Renal cortical cysts (HP:0000803)	2.23067994
43	Abnormality of serum amino acid levels (HP:0003112)	2.22406037
44	Congenital primary aphakia (HP:0007707)	2.21409695
45	Abnormality of urine glucose concentration (HP:0011016)	2.20603331
46	Glycosuria (HP:0003076)	2.20603331
47	Stomatitis (HP:0010280)	2.19592520
48	Abnormal ciliary motility (HP:0012262)	2.19465335
49	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.16828347
50	Short middle phalanx of the 5th finger (HP:0004220)	2.15777240
51	CNS demyelination (HP:0007305)	2.12903562
52	Abnormality of the renal cortex (HP:0011035)	2.11246788
53	Methylmalonic acidemia (HP:0002912)	2.10341961
54	Gait imbalance (HP:0002141)	2.09901480
55	Cerebral edema (HP:0002181)	2.06338566
56	Supernumerary spleens (HP:0009799)	2.05134422
57	Thyroiditis (HP:0100646)	2.00197668
58	Rhinitis (HP:0012384)	1.99470764
59	Abnormal drinking behavior (HP:0030082)	1.99305376
60	Polydipsia (HP:0001959)	1.99305376
61	Nephronophthisis (HP:0000090)	1.99196058
62	Intestinal atresia (HP:0011100)	1.97758121
63	Increased serum pyruvate (HP:0003542)	1.96585161
64	Abnormality of the metopic suture (HP:0005556)	1.95082137
65	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.92097318
66	Anal atresia (HP:0002023)	1.91177377
67	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.89886717
68	X-linked dominant inheritance (HP:0001423)	1.88496623
69	Abnormality of renal resorption (HP:0011038)	1.87549187
70	Shawl scrotum (HP:0000049)	1.86212667
71	Prominent metopic ridge (HP:0005487)	1.85662984
72	Abnormality of cells of the erythroid lineage (HP:0012130)	1.83011196
73	Male pseudohermaphroditism (HP:0000037)	1.81692701
74	Disproportionate short-trunk short stature (HP:0003521)	1.80895068
75	Nephrogenic diabetes insipidus (HP:0009806)	1.80246261
76	Birth length less than 3rd percentile (HP:0003561)	1.80171681
77	Hypoproteinemia (HP:0003075)	1.80045305
78	Methylmalonic aciduria (HP:0012120)	1.79006624
79	Congenital stationary night blindness (HP:0007642)	1.78780156
80	Abnormality of the ileum (HP:0001549)	1.78656178
81	Abnormality of serine family amino acid metabolism (HP:0010894)	1.78609659
82	Abnormality of glycine metabolism (HP:0010895)	1.78609659
83	Respiratory failure (HP:0002878)	1.77698536
84	Abnormality of the heme biosynthetic pathway (HP:0010472)	1.77695327
85	Hypoplasia of the thymus (HP:0000778)	1.74352020
86	Lactic acidosis (HP:0003128)	1.73288389
87	Astigmatism (HP:0000483)	1.72514621
88	Abnormal rod and cone electroretinograms (HP:0008323)	1.72095135
89	Abnormality of magnesium homeostasis (HP:0004921)	1.71529380
90	Absent septum pellucidum (HP:0001331)	1.71501196
91	Preaxial hand polydactyly (HP:0001177)	1.69875931
92	Vaginal atresia (HP:0000148)	1.69585422
93	Median cleft lip (HP:0000161)	1.69515591
94	Cystic liver disease (HP:0006706)	1.69075198
95	Abnormal protein glycosylation (HP:0012346)	1.67969530
96	Abnormal glycosylation (HP:0012345)	1.67969530
97	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.67969530
98	Abnormal protein N-linked glycosylation (HP:0012347)	1.67969530
99	Hypoplasia of the uterus (HP:0000013)	1.67548271
100	Anencephaly (HP:0002323)	1.67093524

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PDK2	3.70003106
2	MAP3K12	3.56333415
3	IRAK1	3.36947287
4	ZAK	3.14255642
5	MAP3K10	3.08647715
6	MST4	2.97187091
7	FRK	2.83369031
8	BUB1	2.41172093
9	MAP4K2	2.37359559
10	PNCK	2.25215936
11	EPHA3	2.24049788
12	WNK3	2.22366457
13	MKNK2	2.20317325
14	TSSK6	2.13943637
15	IRAK2	2.09385383
16	EIF2AK3	2.00376736
17	PBK	1.94313052
18	TLK1	1.78611227
19	TXK	1.70581633
20	BRSK2	1.67985583
21	TGFBR2	1.62459126
22	VRK1	1.52702841
23	PLK3	1.52165793
24	ADRBK2	1.42960411
25	VRK2	1.40511746
26	NUAK1	1.37880387
27	STK39	1.34179026
28	CDC7	1.33952743
29	PRKD3	1.33003123
30	WEE1	1.29496697
31	EPHA4	1.26557382
32	MAPK13	1.25004543
33	WNK4	1.24328990
34	BRD4	1.17820932
35	PASK	1.17499336
36	TNIK	1.17107339
37	OXSR1	1.17014050
38	MKNK1	1.16357355
39	EIF2AK1	1.13240998
40	PKN1	1.09993154
41	ACVR1B	1.09619066
42	NTRK3	1.06539797
43	TRIM28	1.02152729
44	GRK1	0.98023291
45	TAOK3	0.96067232
46	PAK3	0.93382949
47	STK16	0.93153404
48	NEK9	0.90667449
49	NEK1	0.85760259
50	MARK3	0.85577296
51	NTRK2	0.79348868
52	PRKCI	0.77261793
53	PLK2	0.76501230
54	PLK4	0.75851181
55	BMPR1B	0.74969841
56	CASK	0.72415342
57	ALK	0.69815303
58	ATR	0.69467127
59	PLK1	0.66470048
60	CDK8	0.66295926
61	PRKCE	0.65116405
62	AKT3	0.62745331
63	FGFR1	0.62555781
64	CHEK2	0.62217104
65	MINK1	0.62018935
66	RAF1	0.60541581
67	MAP3K2	0.59357657
68	ERBB3	0.59214807
69	FGFR2	0.58649089
70	ATM	0.57903005
71	AURKB	0.55300437
72	RPS6KA5	0.53785130
73	DYRK2	0.52970247
74	ROCK1	0.51196464
75	BCR	0.51033512
76	AURKA	0.49772284
77	NME1	0.48880568
78	CDK3	0.47737199
79	CHEK1	0.47300478
80	NLK	0.44053532
81	MAP3K9	0.42354578
82	SRPK1	0.42101448
83	FGR	0.40716911
84	ARAF	0.40426805
85	PRKCG	0.38867706
86	KSR1	0.38497814
87	IKBKB	0.36809177
88	TAF1	0.36475195
89	PRKACB	0.34993583
90	NEK6	0.34220133
91	LATS1	0.32192971
92	PTK2B	0.32109844
93	STK4	0.31892213
94	CSNK2A1	0.31701708
95	INSRR	0.30942316
96	PRKDC	0.28887390
97	PRKCQ	0.28139892
98	CSNK1E	0.26525844
99	CDK1	0.25663567
100	MYLK	0.23501963

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.12280118
2	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.69427227
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.29364660
4	Non-homologous end-joining_Homo sapiens_hsa03450	3.26396066
5	RNA polymerase_Homo sapiens_hsa03020	3.17449158
6	Protein export_Homo sapiens_hsa03060	3.10366532
7	Basal transcription factors_Homo sapiens_hsa03022	2.41813717
8	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.39825079
9	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.30434836
10	Steroid biosynthesis_Homo sapiens_hsa00100	2.30020712
11	Propanoate metabolism_Homo sapiens_hsa00640	2.19003505
12	Nitrogen metabolism_Homo sapiens_hsa00910	2.18753935
13	Selenocompound metabolism_Homo sapiens_hsa00450	2.18024557
14	RNA transport_Homo sapiens_hsa03013	2.08882710
15	Base excision repair_Homo sapiens_hsa03410	1.83400796
16	Oxidative phosphorylation_Homo sapiens_hsa00190	1.79565768
17	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.74621218
18	Butanoate metabolism_Homo sapiens_hsa00650	1.71463575
19	Nucleotide excision repair_Homo sapiens_hsa03420	1.68779314
20	DNA replication_Homo sapiens_hsa03030	1.68213087
21	Spliceosome_Homo sapiens_hsa03040	1.64444204
22	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.61131613
23	RNA degradation_Homo sapiens_hsa03018	1.53711530
24	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.39087198
25	Homologous recombination_Homo sapiens_hsa03440	1.30912120
26	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.29947826
27	Parkinsons disease_Homo sapiens_hsa05012	1.28592458
28	Pyrimidine metabolism_Homo sapiens_hsa00240	1.27861691
29	Ether lipid metabolism_Homo sapiens_hsa00565	1.24963475
30	Linoleic acid metabolism_Homo sapiens_hsa00591	1.24285012
31	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.21270680
32	One carbon pool by folate_Homo sapiens_hsa00670	1.20826493
33	Caffeine metabolism_Homo sapiens_hsa00232	1.16027927
34	Phototransduction_Homo sapiens_hsa04744	1.15975030
35	Fat digestion and absorption_Homo sapiens_hsa04975	1.15822054
36	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.12502914
37	Fanconi anemia pathway_Homo sapiens_hsa03460	1.08800432
38	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.07875206
39	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.06982645
40	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.05512757
41	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.01589455
42	Primary immunodeficiency_Homo sapiens_hsa05340	0.98090136
43	Peroxisome_Homo sapiens_hsa04146	0.95716327
44	Huntingtons disease_Homo sapiens_hsa05016	0.95119934
45	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.94837172
46	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.93866761
47	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.92985081
48	Sulfur metabolism_Homo sapiens_hsa00920	0.91872765
49	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.91349896
50	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.88789438
51	Collecting duct acid secretion_Homo sapiens_hsa04966	0.87726786
52	Chemical carcinogenesis_Homo sapiens_hsa05204	0.83833529
53	Tryptophan metabolism_Homo sapiens_hsa00380	0.81393000
54	Pyruvate metabolism_Homo sapiens_hsa00620	0.81256164
55	Taste transduction_Homo sapiens_hsa04742	0.81202471
56	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.79869752
57	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.79275551
58	Pentose phosphate pathway_Homo sapiens_hsa00030	0.78653389
59	Retinol metabolism_Homo sapiens_hsa00830	0.76251518
60	Purine metabolism_Homo sapiens_hsa00230	0.75785424
61	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.75437182
62	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.74490054
63	Fatty acid degradation_Homo sapiens_hsa00071	0.71832859
64	beta-Alanine metabolism_Homo sapiens_hsa00410	0.67983333
65	Fatty acid elongation_Homo sapiens_hsa00062	0.67824493
66	Mismatch repair_Homo sapiens_hsa03430	0.63651309
67	Cell cycle_Homo sapiens_hsa04110	0.62945582
68	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.62351102
69	Carbon metabolism_Homo sapiens_hsa01200	0.61138624
70	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.60970864
71	Lysine degradation_Homo sapiens_hsa00310	0.60023080
72	mRNA surveillance pathway_Homo sapiens_hsa03015	0.59453329
73	Metabolic pathways_Homo sapiens_hsa01100	0.57509643
74	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.55025444
75	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.54763807
76	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.54407099
77	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.54038781
78	Sulfur relay system_Homo sapiens_hsa04122	0.53660374
79	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.51305368
80	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.48716910
81	Oocyte meiosis_Homo sapiens_hsa04114	0.45254238
82	Glutathione metabolism_Homo sapiens_hsa00480	0.43836444
83	Alzheimers disease_Homo sapiens_hsa05010	0.41613246
84	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.38491629
85	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.37866802
86	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.35539225
87	Arginine and proline metabolism_Homo sapiens_hsa00330	0.34224734
88	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.32666996
89	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.31053336
90	Glycerolipid metabolism_Homo sapiens_hsa00561	0.30854216
91	Fatty acid metabolism_Homo sapiens_hsa01212	0.29002027
92	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.28690405
93	Nicotine addiction_Homo sapiens_hsa05033	0.27560638
94	Legionellosis_Homo sapiens_hsa05134	0.25706305
95	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.25171905
96	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.24935838
97	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.24691136
98	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.24516711
99	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.24462394
100	Rheumatoid arthritis_Homo sapiens_hsa05323	0.23719651

BTF3P6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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