BTF3P7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell wall macromolecule catabolic process (GO:0016998)7.52794871
2cell wall macromolecule metabolic process (GO:0044036)7.35951382
3maturation of SSU-rRNA (GO:0030490)5.25944991
4labyrinthine layer development (GO:0060711)4.96050611
5ribosomal small subunit assembly (GO:0000028)4.92125388
6exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.88118357
7nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.55241244
8ATP synthesis coupled proton transport (GO:0015986)4.08582703
9energy coupled proton transport, down electrochemical gradient (GO:0015985)4.08582703
10positive regulation of digestive system process (GO:0060456)4.06299032
11L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.96919255
12piRNA metabolic process (GO:0034587)3.95490606
13DNA deamination (GO:0045006)3.94211316
14purine nucleotide salvage (GO:0032261)3.85661119
15cullin deneddylation (GO:0010388)3.76323262
16interferon-gamma production (GO:0032609)3.73798512
17regulation of skeletal muscle contraction (GO:0014819)3.71463434
18regulation of interleukin-8 biosynthetic process (GO:0045414)3.71247999
19mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.68927032
20response to nitric oxide (GO:0071731)3.58673187
21mitochondrial respiratory chain complex I assembly (GO:0032981)3.56841814
22NADH dehydrogenase complex assembly (GO:0010257)3.56841814
23mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.56841814
24inner mitochondrial membrane organization (GO:0007007)3.54446276
25viral transcription (GO:0019083)3.48465702
26multicellular organismal aging (GO:0010259)3.47331358
27purine deoxyribonucleotide catabolic process (GO:0009155)3.44628589
28chaperone-mediated protein transport (GO:0072321)3.41615866
29nucleotide transmembrane transport (GO:1901679)3.36747645
30organic cation transport (GO:0015695)3.33856866
31ribosomal small subunit biogenesis (GO:0042274)3.30913838
32L-methionine salvage (GO:0071267)3.30198082
33L-methionine biosynthetic process (GO:0071265)3.30198082
34amino acid salvage (GO:0043102)3.30198082
35pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.24907961
36rRNA modification (GO:0000154)3.23309235
37toxin transport (GO:1901998)3.21977774
38negative regulation of interleukin-1 beta production (GO:0032691)3.17885835
39purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.17161002
40translational termination (GO:0006415)3.17121831
41deoxyribonucleotide catabolic process (GO:0009264)3.15688587
42protein complex biogenesis (GO:0070271)3.14013928
43AMP metabolic process (GO:0046033)3.11563152
44pseudouridine synthesis (GO:0001522)3.11438151
45ribosomal large subunit biogenesis (GO:0042273)3.10044374
46protein deneddylation (GO:0000338)3.09680068
47SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.07875049
48translation (GO:0006412)3.05258358
49positive regulation of prostaglandin secretion (GO:0032308)3.05178360
50RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.04500000
51deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.03314012
52autophagic vacuole fusion (GO:0000046)3.03273352
53GTP biosynthetic process (GO:0006183)3.01130347
54mitochondrial respiratory chain complex assembly (GO:0033108)2.99608181
55deoxyribose phosphate catabolic process (GO:0046386)2.98675014
564-hydroxyproline metabolic process (GO:0019471)2.98168862
57cotranslational protein targeting to membrane (GO:0006613)2.97110610
58rRNA metabolic process (GO:0016072)2.96952039
59translational elongation (GO:0006414)2.96819226
60rRNA processing (GO:0006364)2.96493571
61protein targeting to ER (GO:0045047)2.94630716
62nucleotide salvage (GO:0043173)2.92387126
63DNA methylation involved in gamete generation (GO:0043046)2.92084104
64protein neddylation (GO:0045116)2.89371551
65spliceosomal snRNP assembly (GO:0000387)2.89294098
66negative regulation of interleukin-1 production (GO:0032692)2.83602716
67positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.82084815
68negative regulation of interleukin-8 production (GO:0032717)2.81985325
69UTP biosynthetic process (GO:0006228)2.81596829
70nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:0000288)2.80739894
71carnitine transmembrane transport (GO:1902603)2.78797919
72negative regulation of muscle hypertrophy (GO:0014741)2.77841240
73grooming behavior (GO:0007625)2.74479633
74protein localization to endoplasmic reticulum (GO:0070972)2.74103055
75establishment of protein localization to endoplasmic reticulum (GO:0072599)2.73703028
76G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.72873214
77preassembly of GPI anchor in ER membrane (GO:0016254)2.67883762
78water-soluble vitamin biosynthetic process (GO:0042364)2.67548012
79translational initiation (GO:0006413)2.66851779
80positive regulation of T cell chemotaxis (GO:0010820)2.66693356
81regulation of T cell chemotaxis (GO:0010819)2.66693356
82positive regulation of monocyte chemotaxis (GO:0090026)2.66120383
83somite development (GO:0061053)2.65228284
84nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.64227614
85protoporphyrinogen IX metabolic process (GO:0046501)2.64204185
86mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.62147274
87regulation of prostaglandin secretion (GO:0032306)2.61790792
88pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.60680365
89adaptation of signaling pathway (GO:0023058)2.60196100
90cellular component biogenesis (GO:0044085)2.58096286
91positive regulation of icosanoid secretion (GO:0032305)2.57222820
92protein-cofactor linkage (GO:0018065)2.55544693
93rRNA methylation (GO:0031167)2.55442731
94behavioral response to nicotine (GO:0035095)2.54269105
95ribonucleoprotein complex biogenesis (GO:0022613)2.52233836
96heart trabecula formation (GO:0060347)2.51998598
97cellular response to exogenous dsRNA (GO:0071360)2.51691817
98transcription elongation from RNA polymerase III promoter (GO:0006385)2.50132595
99termination of RNA polymerase III transcription (GO:0006386)2.50132595
1002-deoxyribonucleotide metabolic process (GO:0009394)2.50031720

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ELF1_17652178_ChIP-ChIP_JURKAT_Human5.86000414
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.18443389
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.83012836
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.72800964
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.67586979
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.65592218
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.56966587
8IGF1R_20145208_ChIP-Seq_DFB_Human2.97152648
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.96550461
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.76584826
11CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.74395166
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.67008939
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.47655971
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.41642210
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.37530559
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.33968913
17FOXP3_21729870_ChIP-Seq_TREG_Human2.32270223
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.28470396
19VDR_23849224_ChIP-Seq_CD4+_Human2.27117160
20VDR_22108803_ChIP-Seq_LS180_Human2.25296475
21PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse2.23872090
22SRF_21415370_ChIP-Seq_HL-1_Mouse2.21992543
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.15277642
24EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.11097201
25THAP11_20581084_ChIP-Seq_MESCs_Mouse1.90081094
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.86948614
27FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.79034100
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.74198714
29LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.73379085
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.71608861
31CREB1_15753290_ChIP-ChIP_HEK293T_Human1.67213511
32TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.67054435
33TTF2_22483619_ChIP-Seq_HELA_Human1.65586573
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.64541564
35ZNF274_21170338_ChIP-Seq_K562_Hela1.58525710
36MYC_18358816_ChIP-ChIP_MESCs_Mouse1.57839274
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.52524429
38DCP1A_22483619_ChIP-Seq_HELA_Human1.50103794
39RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.45899180
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.43397289
41IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.43315505
42CIITA_25753668_ChIP-Seq_RAJI_Human1.42301726
43ELK1_19687146_ChIP-ChIP_HELA_Human1.42242229
44CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.42165640
45SPI1_23547873_ChIP-Seq_NB4_Human1.40898325
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.37576575
47NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.35826984
48ELF5_23300383_ChIP-Seq_T47D_Human1.34377143
49MYC_19030024_ChIP-ChIP_MESCs_Mouse1.33173539
50IRF8_27001747_Chip-Seq_BMDM_Mouse1.32217957
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31875975
52EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.31802452
53GATA3_26560356_Chip-Seq_TH2_Human1.30984177
54GABP_19822575_ChIP-Seq_HepG2_Human1.27614776
55NOTCH1_21737748_ChIP-Seq_TLL_Human1.23495508
56POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.23079768
57FLI1_27457419_Chip-Seq_LIVER_Mouse1.22511467
58PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.21005081
59LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.19712962
60SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.18620802
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.17709623
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16851953
63AR_20517297_ChIP-Seq_VCAP_Human1.16582015
64RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.14919836
65IRF1_19129219_ChIP-ChIP_H3396_Human1.13992491
66PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13638864
67EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.10046633
68FOXA1_27270436_Chip-Seq_PROSTATE_Human1.09132063
69FOXA1_25329375_ChIP-Seq_VCAP_Human1.09132063
70MYC_19079543_ChIP-ChIP_MESCs_Mouse1.05585096
71HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.04049685
72PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03705825
73E2F1_18555785_ChIP-Seq_MESCs_Mouse1.02558060
74HTT_18923047_ChIP-ChIP_STHdh_Human1.01990582
75ELK1_22589737_ChIP-Seq_MCF10A_Human1.01988620
76CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01584410
77CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.01423852
78VDR_24787735_ChIP-Seq_THP-1_Human1.00494068
79MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.99666281
80MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.98115219
81RUNX_20019798_ChIP-Seq_JUKART_Human0.97792506
82TP53_22573176_ChIP-Seq_HFKS_Human0.97174322
83MYB_26560356_Chip-Seq_TH2_Human0.96922848
84CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94615653
85PCGF2_27294783_Chip-Seq_ESCs_Mouse0.94056771
86HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.94032159
87YY1_22570637_ChIP-Seq_MALME-3M_Human0.93916641
88XRN2_22483619_ChIP-Seq_HELA_Human0.93383491
89FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92774281
90PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92595011
91ERG_20887958_ChIP-Seq_HPC-7_Mouse0.92039358
92LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91627661
93CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91596530
94POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.90410703
95MYB_26560356_Chip-Seq_TH1_Human0.90317655
96FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.89511654
97SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88563424
98STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.88223251
99STAT1_20625510_ChIP-Seq_HELA_Human0.87580139
100GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.87486626

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.39451040
2MP0005083_abnormal_biliary_tract3.61829756
3MP0005671_abnormal_response_to3.46722747
4MP0005167_abnormal_blood-brain_barrier3.04231343
5MP0003786_premature_aging2.95423386
6MP0002132_abnormal_respiratory_system2.88069867
7MP0001835_abnormal_antigen_presentation2.79394524
8MP0002138_abnormal_hepatobiliary_system2.64498820
9MP0002148_abnormal_hypersensitivity_rea2.63852886
10MP0005058_abnormal_lysosome_morphology2.31165417
11MP0000685_abnormal_immune_system2.22721283
12MP0004147_increased_porphyrin_level2.22160344
13MP0003646_muscle_fatigue2.19369616
14MP0003866_abnormal_defecation2.06981127
15MP0001853_heart_inflammation2.01799410
16MP0000383_abnormal_hair_follicle1.98288222
17MP0002419_abnormal_innate_immunity1.92906457
18MP0002277_abnormal_respiratory_mucosa1.85398201
19MP0005084_abnormal_gallbladder_morpholo1.83395692
20MP0004484_altered_response_of1.78206414
21MP0006082_CNS_inflammation1.77132240
22MP0004145_abnormal_muscle_electrophysio1.75357006
23MP0005025_abnormal_response_to1.75198776
24MP0009785_altered_susceptibility_to1.57070934
25MP0002420_abnormal_adaptive_immunity1.56283208
26MP0005646_abnormal_pituitary_gland1.55389784
27MP0002452_abnormal_antigen_presenting1.55331569
28MP0000604_amyloidosis1.54800519
29MP0005000_abnormal_immune_tolerance1.54254555
30MP0001819_abnormal_immune_cell1.53420573
31MP0005410_abnormal_fertilization1.51185220
32MP0000343_altered_response_to1.50778949
33MP0002723_abnormal_immune_serum1.50772191
34MP0004134_abnormal_chest_morphology1.49424859
35MP0000749_muscle_degeneration1.46029876
36MP0004510_myositis1.45966437
37MP0008875_abnormal_xenobiotic_pharmacok1.44943058
38MP0001800_abnormal_humoral_immune1.43849386
39MP0003724_increased_susceptibility_to1.39571680
40MP0003567_abnormal_fetal_cardiomyocyte1.38441718
41MP0008877_abnormal_DNA_methylation1.27494443
42MP0008995_early_reproductive_senescence1.25779378
43MP0005387_immune_system_phenotype1.25696187
44MP0001790_abnormal_immune_system1.25696187
45MP0000716_abnormal_immune_system1.23683838
46MP0004742_abnormal_vestibular_system1.23573161
47MP0003303_peritoneal_inflammation1.21614238
48MP0009333_abnormal_splenocyte_physiolog1.19454152
49MP0002160_abnormal_reproductive_system1.18431169
50MP0003195_calcinosis1.18020336
51MP0010678_abnormal_skin_adnexa1.17370175
52MP0000920_abnormal_myelination1.16360202
53MP0002405_respiratory_system_inflammati1.16082808
54MP0001845_abnormal_inflammatory_respons1.11598853
55MP0005075_abnormal_melanosome_morpholog1.11083913
56MP0001542_abnormal_bone_strength1.10760139
57MP0005332_abnormal_amino_acid1.10630988
58MP0001440_abnormal_grooming_behavior1.09861166
59MP0004947_skin_inflammation1.09399285
60MP0005365_abnormal_bile_salt1.06065632
61MP0005389_reproductive_system_phenotype1.05655649
62MP0004142_abnormal_muscle_tone1.04834260
63MP0005379_endocrine/exocrine_gland_phen1.04459354
64MP0000689_abnormal_spleen_morphology1.03840016
65MP0002429_abnormal_blood_cell1.03710451
66MP0002876_abnormal_thyroid_physiology1.02853799
67MP0002102_abnormal_ear_morphology1.02059505
68MP0003436_decreased_susceptibility_to1.01162923
69MP0001545_abnormal_hematopoietic_system0.98751529
70MP0005397_hematopoietic_system_phenotyp0.98751529
71MP0008469_abnormal_protein_level0.98403239
72MP0002398_abnormal_bone_marrow0.97910650
73MP0000858_altered_metastatic_potential0.95627891
74MP0002837_dystrophic_cardiac_calcinosis0.95488966
75MP0006035_abnormal_mitochondrial_morpho0.95395003
76MP0003763_abnormal_thymus_physiology0.95300181
77MP0003329_amyloid_beta_deposits0.93925399
78MP0005464_abnormal_platelet_physiology0.93399327
79MP0002722_abnormal_immune_system0.91977152
80MP0003315_abnormal_perineum_morphology0.91593435
81MP0009765_abnormal_xenobiotic_induced0.90631164
82MP0005266_abnormal_metabolism0.89306451
83MP0005330_cardiomyopathy0.87730806
84MP0003959_abnormal_lean_body0.87069343
85MP0006036_abnormal_mitochondrial_physio0.85661653
86MP0000490_abnormal_crypts_of0.84462029
87MP0002229_neurodegeneration0.82301846
88MP0002163_abnormal_gland_morphology0.81889669
89MP0005310_abnormal_salivary_gland0.81385329
90MP0000613_abnormal_salivary_gland0.80813317
91MP0004381_abnormal_hair_follicle0.80432172
92MP0003638_abnormal_response/metabolism_0.80407318
93MP0000647_abnormal_sebaceous_gland0.79942641
94MP0002332_abnormal_exercise_endurance0.79126745
95MP0009764_decreased_sensitivity_to0.78319970
96MP0006292_abnormal_olfactory_placode0.77668947
97MP0003186_abnormal_redox_activity0.75602329
98MP0002090_abnormal_vision0.75180039
99MP0005551_abnormal_eye_electrophysiolog0.74450353
100MP0009278_abnormal_bone_marrow0.74361475

Predicted human phenotypes

RankGene SetZ-score
1Increased hepatocellular lipid droplets (HP:0006565)3.92084076
2Lipid accumulation in hepatocytes (HP:0006561)3.89224031
3Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.79983735
4Acute necrotizing encephalopathy (HP:0006965)3.57734989
5Abnormality of the renal collecting system (HP:0004742)3.57587258
6Renal Fanconi syndrome (HP:0001994)3.55962428
7Duplicated collecting system (HP:0000081)3.45174238
8Onycholysis (HP:0001806)3.41196838
9Loss of speech (HP:0002371)3.39384865
10Adactyly (HP:0009776)3.38321032
11Vacuolated lymphocytes (HP:0001922)3.37600803
12Abnormal mitochondria in muscle tissue (HP:0008316)3.37235311
13Elevated erythrocyte sedimentation rate (HP:0003565)3.27923023
14Mitochondrial inheritance (HP:0001427)3.25539643
15Reticulocytopenia (HP:0001896)3.20199773
16Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.15972155
17Decreased electroretinogram (ERG) amplitude (HP:0000654)3.14673834
18Hypoplasia of the uterus (HP:0000013)3.09958318
19Increased CSF lactate (HP:0002490)3.09064041
20Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.06535678
21Abnormality of alanine metabolism (HP:0010916)3.06535678
22Hyperalaninemia (HP:0003348)3.06535678
23Increased cerebral lipofuscin (HP:0011813)3.05577720
24Confusion (HP:0001289)3.01389238
25Increased neuronal autofluorescent lipopigment (HP:0002074)3.00833396
26Stomatitis (HP:0010280)2.99356132
27Progressive macrocephaly (HP:0004481)2.94754475
28Paralysis (HP:0003470)2.91341031
29Absent rod-and cone-mediated responses on ERG (HP:0007688)2.90668860
30Absent phalangeal crease (HP:0006109)2.86907021
31Acute encephalopathy (HP:0006846)2.83288809
32Increased intramyocellular lipid droplets (HP:0012240)2.81041990
33Abnormality of glycolipid metabolism (HP:0010969)2.80721043
34Abnormality of liposaccharide metabolism (HP:0010968)2.80721043
35Abnormality of glycosphingolipid metabolism (HP:0004343)2.80721043
36Aplasia/hypoplasia of the uterus (HP:0008684)2.75116672
37Increased serum lactate (HP:0002151)2.66678298
38Abnormal finger flexion creases (HP:0006143)2.65656013
39Porencephaly (HP:0002132)2.59491653
40Abolished electroretinogram (ERG) (HP:0000550)2.58233232
41Exertional dyspnea (HP:0002875)2.57552999
423-Methylglutaconic aciduria (HP:0003535)2.56483914
43Polycythemia (HP:0001901)2.52128913
44Increased muscle lipid content (HP:0009058)2.50767736
45Petechiae (HP:0000967)2.44479581
46Microretrognathia (HP:0000308)2.43770556
47Glycosuria (HP:0003076)2.40239054
48Abnormality of urine glucose concentration (HP:0011016)2.40239054
49Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.38790689
50Cerebral edema (HP:0002181)2.38735897
51Reduced antithrombin III activity (HP:0001976)2.38391599
52Abnormal number of erythroid precursors (HP:0012131)2.38369650
53Lactic acidosis (HP:0003128)2.30115189
54Ureteral stenosis (HP:0000071)2.30031982
55Respiratory difficulties (HP:0002880)2.28107096
56Thrombocytosis (HP:0001894)2.23668087
57Pendular nystagmus (HP:0012043)2.23635375
58Autoimmune thrombocytopenia (HP:0001973)2.23262032
59Macrocytic anemia (HP:0001972)2.21395495
60Optic disc pallor (HP:0000543)2.20874573
61Tongue fasciculations (HP:0001308)2.20076195
62Abnormality of cells of the erythroid lineage (HP:0012130)2.16439036
63Abnormal rod and cone electroretinograms (HP:0008323)2.13157006
64Abnormality of the phalanges of the 5th finger (HP:0004213)2.11149052
65IgG deficiency (HP:0004315)2.10985367
66Pancreatic cysts (HP:0001737)2.10712796
67Abnormality of renal resorption (HP:0011038)2.09632301
68Broad-based gait (HP:0002136)2.09519148
69Ureteral obstruction (HP:0006000)2.07181029
70Hypergonadotropic hypogonadism (HP:0000815)2.06653707
71Testicular atrophy (HP:0000029)2.06487245
72Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.05510937
73Lethargy (HP:0001254)2.04502443
74Respiratory failure (HP:0002878)2.03819420
75Ureteral duplication (HP:0000073)2.02944823
76Palpitations (HP:0001962)2.02499216
77Urinary bladder sphincter dysfunction (HP:0002839)2.01305782
78Constricted visual fields (HP:0001133)2.00791708
79Type I transferrin isoform profile (HP:0003642)1.98937111
80Anhidrosis (HP:0000970)1.98415131
81Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.96359561
82Disinhibition (HP:0000734)1.94729841
83Myositis (HP:0100614)1.93140107
84Methylmalonic aciduria (HP:0012120)1.92007584
85Abnormality of midbrain morphology (HP:0002418)1.88700243
86Molar tooth sign on MRI (HP:0002419)1.88700243
87Small hand (HP:0200055)1.88458901
88Muscle fibrillation (HP:0010546)1.85795656
89Conjunctival hamartoma (HP:0100780)1.84993068
90Exercise intolerance (HP:0003546)1.83510488
91Increased corneal curvature (HP:0100692)1.83160671
92Keratoconus (HP:0000563)1.83160671
93Congenital stationary night blindness (HP:0007642)1.82396285
94Recurrent abscess formation (HP:0002722)1.80761626
95Posterior subcapsular cataract (HP:0007787)1.80640196
96Abnormality of the middle phalanges of the toes (HP:0010183)1.79006278
97Agitation (HP:0000713)1.77674841
98Mediastinal lymphadenopathy (HP:0100721)1.77168223
99Palpebral edema (HP:0100540)1.76726426
100Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.76035674

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.73758338
2TAOK34.45742686
3NME24.22058531
4PBK4.00724696
5BCKDK3.28256336
6STK163.27490159
7GRK73.04561552
8SCYL22.98846631
9TGFBR22.41773271
10TIE12.38503261
11MOS2.34761434
12EIF2AK12.04853010
13MST41.87458643
14NUAK11.77172189
15ACVR1B1.72710124
16MAP3K61.56041073
17MAP2K31.54473383
18ZAK1.53357514
19LMTK21.50057298
20PLK41.47171317
21MAP2K61.42744329
22FES1.29484461
23GRK51.27977687
24MAP4K11.24583541
25TESK21.21912006
26GRK11.21655219
27MAPK131.07800663
28TYK21.01218935
29WNK40.98341970
30TBK10.95463944
31ADRBK20.94868623
32PHKG20.93549603
33PHKG10.93549603
34CDK190.93300822
35DAPK10.92087156
36VRK20.91492397
37STK100.90669501
38MAPK70.86314143
39LIMK10.81174248
40SRPK10.78948838
41TGFBR10.76492779
42CSF1R0.75790314
43PINK10.74224225
44DAPK20.73683086
45KIT0.73601886
46OXSR10.72859328
47ITK0.71235748
48EIF2AK20.69854821
49NEK90.65874767
50ZAP700.64707619
51EPHB20.64155860
52IKBKE0.62745951
53KSR10.62440660
54ABL20.61400674
55IKBKB0.60869369
56JAK30.59740878
57ADRBK10.59644303
58PDK20.57519849
59BMPR1B0.55679442
60TEC0.55499661
61MAP4K20.54147566
62TSSK60.52142361
63IGF1R0.51552246
64MAP2K40.51527150
65BLK0.51047077
66CDK80.49017113
67LYN0.48530129
68FRK0.46991015
69PIK3CA0.46825967
70ILK0.45836193
71STK390.45753820
72MAP3K50.45447310
73PRKCQ0.44842146
74PRKG20.43188577
75SYK0.42291969
76CAMKK20.39145104
77EIF2AK30.36510410
78TAF10.33355418
79MINK10.33303592
80MARK30.33096408
81PLK30.32072199
82LCK0.31982902
83AURKA0.31904496
84PIK3CG0.30797369
85FYN0.30427378
86CAMK1D0.29976748
87VRK10.29847328
88OBSCN0.28748234
89CSNK1G30.28214433
90STK240.27907930
91MAPKAPK30.27820602
92TLK10.27524539
93CSNK1G20.27181963
94RIPK40.26452003
95PDK10.25754556
96RPS6KB10.23991802
97INSRR0.22923979
98PRKCD0.20124155
99BUB10.19900197
100EGFR0.18919292

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.84107858
2Oxidative phosphorylation_Homo sapiens_hsa001903.28687219
3Proteasome_Homo sapiens_hsa030503.10136341
4Asthma_Homo sapiens_hsa053102.87663220
5Sulfur metabolism_Homo sapiens_hsa009202.74857569
6RNA degradation_Homo sapiens_hsa030182.53730864
7Parkinsons disease_Homo sapiens_hsa050122.44638881
8Sulfur relay system_Homo sapiens_hsa041222.43983548
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.16619549
10Antigen processing and presentation_Homo sapiens_hsa046122.12489884
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.01201695
12Pyrimidine metabolism_Homo sapiens_hsa002401.96042314
13Protein export_Homo sapiens_hsa030601.95694789
14RNA polymerase_Homo sapiens_hsa030201.91985510
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.90136614
16Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.89480371
17Spliceosome_Homo sapiens_hsa030401.81390079
18Linoleic acid metabolism_Homo sapiens_hsa005911.76659556
19Rheumatoid arthritis_Homo sapiens_hsa053231.75903720
20Cyanoamino acid metabolism_Homo sapiens_hsa004601.70033042
21Collecting duct acid secretion_Homo sapiens_hsa049661.69171247
22Alzheimers disease_Homo sapiens_hsa050101.67211001
23Huntingtons disease_Homo sapiens_hsa050161.64040883
24Allograft rejection_Homo sapiens_hsa053301.63580544
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.62838166
26Lysosome_Homo sapiens_hsa041421.53788350
27DNA replication_Homo sapiens_hsa030301.50068207
28Ether lipid metabolism_Homo sapiens_hsa005651.49972522
29Phototransduction_Homo sapiens_hsa047441.48226981
30Autoimmune thyroid disease_Homo sapiens_hsa053201.46206433
31Peroxisome_Homo sapiens_hsa041461.35254923
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.33322132
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.31604817
34Graft-versus-host disease_Homo sapiens_hsa053321.27749618
35Fanconi anemia pathway_Homo sapiens_hsa034601.26519140
36Caffeine metabolism_Homo sapiens_hsa002321.25784219
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.24395346
38Purine metabolism_Homo sapiens_hsa002301.22072001
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.15492696
40Fatty acid elongation_Homo sapiens_hsa000621.06425724
41Basal transcription factors_Homo sapiens_hsa030221.04847511
42Hematopoietic cell lineage_Homo sapiens_hsa046401.03806028
43Glutathione metabolism_Homo sapiens_hsa004801.01828719
44RNA transport_Homo sapiens_hsa030131.00289087
45Arachidonic acid metabolism_Homo sapiens_hsa005900.99784136
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.97298479
47Type I diabetes mellitus_Homo sapiens_hsa049400.97132811
48Staphylococcus aureus infection_Homo sapiens_hsa051500.93153750
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.91479491
50Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.90474738
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.90259128
52NOD-like receptor signaling pathway_Homo sapiens_hsa046210.85747654
53Cardiac muscle contraction_Homo sapiens_hsa042600.84436524
54Chemical carcinogenesis_Homo sapiens_hsa052040.83688197
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78827942
56Drug metabolism - other enzymes_Homo sapiens_hsa009830.75339650
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74291563
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70410126
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.67603461
60Viral myocarditis_Homo sapiens_hsa054160.67039676
61Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.65163183
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64792009
63Retinol metabolism_Homo sapiens_hsa008300.63719925
64Metabolic pathways_Homo sapiens_hsa011000.57076447
65Leishmaniasis_Homo sapiens_hsa051400.53891212
66Propanoate metabolism_Homo sapiens_hsa006400.52431477
67Phagosome_Homo sapiens_hsa041450.51829202
68RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.51703479
69Tryptophan metabolism_Homo sapiens_hsa003800.51185599
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50975977
71Mineral absorption_Homo sapiens_hsa049780.50921406
72Tuberculosis_Homo sapiens_hsa051520.49864330
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45965467
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45624530
75Folate biosynthesis_Homo sapiens_hsa007900.44848207
76Vibrio cholerae infection_Homo sapiens_hsa051100.44767592
77Salivary secretion_Homo sapiens_hsa049700.44554538
78Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.42047236
79Osteoclast differentiation_Homo sapiens_hsa043800.40459332
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39660991
81Butanoate metabolism_Homo sapiens_hsa006500.37945514
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37580604
83p53 signaling pathway_Homo sapiens_hsa041150.37335456
84Base excision repair_Homo sapiens_hsa034100.37157164
85Legionellosis_Homo sapiens_hsa051340.36971763
86Epstein-Barr virus infection_Homo sapiens_hsa051690.35581235
87Jak-STAT signaling pathway_Homo sapiens_hsa046300.34629648
88Nicotine addiction_Homo sapiens_hsa050330.34189840
89Nitrogen metabolism_Homo sapiens_hsa009100.33847674
90Glycosaminoglycan degradation_Homo sapiens_hsa005310.33071499
91Fatty acid biosynthesis_Homo sapiens_hsa000610.32494096
92Ovarian steroidogenesis_Homo sapiens_hsa049130.30110698
93Regulation of autophagy_Homo sapiens_hsa041400.30108338
94Primary immunodeficiency_Homo sapiens_hsa053400.29756407
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.28818787
96Nucleotide excision repair_Homo sapiens_hsa034200.27917816
97Measles_Homo sapiens_hsa051620.25438321
98NF-kappa B signaling pathway_Homo sapiens_hsa040640.23898248
99Systemic lupus erythematosus_Homo sapiens_hsa053220.23160388
100Homologous recombination_Homo sapiens_hsa034400.22190159

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