BTF3P9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.30027674
2cytidine deamination (GO:0009972)7.02240790
3cytidine metabolic process (GO:0046087)7.02240790
4cytidine catabolic process (GO:0006216)7.02240790
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.95246316
6pyrimidine ribonucleoside catabolic process (GO:0046133)5.94473323
7Arp2/3 complex-mediated actin nucleation (GO:0034314)5.25267473
8negative regulation of T cell apoptotic process (GO:0070233)5.02112125
9sequestering of actin monomers (GO:0042989)4.91221391
10positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.76614285
11actin nucleation (GO:0045010)4.75795811
12positive thymic T cell selection (GO:0045059)4.74150842
13positive regulation of natural killer cell mediated immunity (GO:0002717)4.66049934
14positive T cell selection (GO:0043368)4.62626104
15negative regulation by host of viral transcription (GO:0043922)4.57395066
16regulation of activation of Janus kinase activity (GO:0010533)4.49592346
17cytolysis (GO:0019835)4.40108462
18ribosomal small subunit assembly (GO:0000028)4.20780758
19positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.15207987
20T cell migration (GO:0072678)4.06808250
21antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.05607347
22regulation of natural killer cell mediated immunity (GO:0002715)4.04212131
23regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.04212131
24regulation of B cell receptor signaling pathway (GO:0050855)3.95399805
25positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.93584244
26positive regulation of interleukin-8 secretion (GO:2000484)3.84884148
27positive regulation of translational initiation (GO:0045948)3.76135993
28positive regulation of T cell mediated cytotoxicity (GO:0001916)3.64559071
29positive regulation of calcium-mediated signaling (GO:0050850)3.57615369
30positive regulation of B cell differentiation (GO:0045579)3.54290893
31regulation of regulatory T cell differentiation (GO:0045589)3.53790025
32regulation of leukocyte mediated cytotoxicity (GO:0001910)3.50497533
33metallo-sulfur cluster assembly (GO:0031163)3.47267073
34iron-sulfur cluster assembly (GO:0016226)3.47267073
35eosinophil chemotaxis (GO:0048245)3.47107076
36negative regulation of lymphocyte apoptotic process (GO:0070229)3.46341131
37regulation of T cell apoptotic process (GO:0070232)3.45181332
38negative regulation of mast cell activation (GO:0033004)3.41940838
39negative T cell selection (GO:0043383)3.39856112
40positive regulation of tolerance induction (GO:0002645)3.39746207
41pyrimidine nucleoside catabolic process (GO:0046135)3.37599509
42positive regulation of gamma-delta T cell activation (GO:0046645)3.36888730
43platelet dense granule organization (GO:0060155)3.34942072
44negative regulation of viral genome replication (GO:0045071)3.34794043
45positive regulation of cell killing (GO:0031343)3.33561170
46T cell receptor signaling pathway (GO:0050852)3.27382107
47regulation of T cell receptor signaling pathway (GO:0050856)3.24338359
48thymic T cell selection (GO:0045061)3.22066864
49response to interferon-beta (GO:0035456)3.22012121
50regulation of T cell mediated cytotoxicity (GO:0001914)3.21296038
51negative regulation of oxidoreductase activity (GO:0051354)3.18893795
52positive regulation of T cell apoptotic process (GO:0070234)3.16632217
53eosinophil migration (GO:0072677)3.16466881
54negative regulation of stress fiber assembly (GO:0051497)3.12302131
55regulation of cellular amino acid metabolic process (GO:0006521)3.10766695
56mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.05909758
57antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.02626601
58regulation of B cell differentiation (GO:0045577)3.00903611
59regulation of cell killing (GO:0031341)3.00646329
60DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.98875062
61negative regulation of actin filament bundle assembly (GO:0032232)2.97729025
62regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.97215160
63regulation of interleukin-8 secretion (GO:2000482)2.96308789
64T cell costimulation (GO:0031295)2.96186283
65positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.94338481
66cellular response to interleukin-15 (GO:0071350)2.94094053
67lymphocyte costimulation (GO:0031294)2.92907868
68regulation of chronic inflammatory response (GO:0002676)2.92590797
69antigen receptor-mediated signaling pathway (GO:0050851)2.91156682
70positive regulation of T cell chemotaxis (GO:0010820)2.90184348
71regulation of T cell chemotaxis (GO:0010819)2.90184348
72regulation of gamma-delta T cell differentiation (GO:0045586)2.88080589
73regulation of T cell tolerance induction (GO:0002664)2.86575996
74signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.86340458
75intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.86340458
76positive regulation of monocyte chemotaxis (GO:0090026)2.85268922
77T cell selection (GO:0045058)2.85020772
78deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.84506595
79signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.84474925
80signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.84474925
81signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.84474925
82macrophage chemotaxis (GO:0048246)2.81023983
83antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.79916989
84natural killer cell activation (GO:0030101)2.78444350
85negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.77152540
86respiratory electron transport chain (GO:0022904)2.75328673
87mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.75168967
88negative regulation of calcium ion transport into cytosol (GO:0010523)2.75131160
89immunoglobulin mediated immune response (GO:0016064)2.72164008
90regulation of lymphocyte chemotaxis (GO:1901623)2.71856546
91protein neddylation (GO:0045116)2.71151881
92electron transport chain (GO:0022900)2.70802754
93ATP synthesis coupled proton transport (GO:0015986)2.67760657
94energy coupled proton transport, down electrochemical gradient (GO:0015985)2.67760657
95purine nucleotide salvage (GO:0032261)2.66713069
96respiratory burst (GO:0045730)2.66678237
97negative regulation of nitric-oxide synthase activity (GO:0051001)2.66460171
98positive regulation of lymphocyte migration (GO:2000403)2.66313197
99negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.66125769
100signal transduction involved in DNA integrity checkpoint (GO:0072401)2.64154821

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.39630672
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.24101066
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.95866906
4ELF1_17652178_ChIP-ChIP_JURKAT_Human3.93076552
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.59666439
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.25468789
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.14688402
8IRF8_22096565_ChIP-ChIP_GC-B_Human3.12175046
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.84771122
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.81549032
11MYB_26560356_Chip-Seq_TH2_Human2.50629208
12VDR_22108803_ChIP-Seq_LS180_Human2.46111647
13RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.27704052
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.24161500
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.22114681
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.21925847
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.11707474
18NOTCH1_21737748_ChIP-Seq_TLL_Human2.10069650
19EZH2_22144423_ChIP-Seq_EOC_Human2.05323941
20ZNF274_21170338_ChIP-Seq_K562_Hela2.01388118
21LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.93552022
22EST1_17652178_ChIP-ChIP_JURKAT_Human1.93465745
23STAT4_19710469_ChIP-ChIP_TH1__Mouse1.82912425
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.79819974
25VDR_23849224_ChIP-Seq_CD4+_Human1.79540027
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.77861523
27KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.77217332
28GATA3_27048872_Chip-Seq_THYMUS_Human1.74426860
29RUNX_20019798_ChIP-Seq_JUKART_Human1.67071147
30FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.59568351
31SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.59350682
32MYB_26560356_Chip-Seq_TH1_Human1.51947483
33IGF1R_20145208_ChIP-Seq_DFB_Human1.51248343
34RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.47631766
35GATA3_26560356_Chip-Seq_TH2_Human1.43289890
36STAT6_21828071_ChIP-Seq_BEAS2B_Human1.41724585
37UTX_26944678_Chip-Seq_JUKART_Human1.39612285
38FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.38919815
39FLI1_27457419_Chip-Seq_LIVER_Mouse1.37024756
40PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.32932034
41ETS1_20019798_ChIP-Seq_JURKAT_Human1.31850398
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.31260852
43FOXP3_21729870_ChIP-Seq_TREG_Human1.30275763
44SRF_21415370_ChIP-Seq_HL-1_Mouse1.28918024
45NANOG_20526341_ChIP-Seq_ESCs_Human1.25256312
46TP53_22573176_ChIP-Seq_HFKS_Human1.24445685
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23739401
48PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.19680445
49EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.18904722
50HTT_18923047_ChIP-ChIP_STHdh_Human1.18039396
51CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.17154331
52AR_20517297_ChIP-Seq_VCAP_Human1.17116449
53TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.15976080
54MAF_26560356_Chip-Seq_TH2_Human1.14170345
55BCL6_27268052_Chip-Seq_Bcells_Human1.12252834
56SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.12251391
57ELK1_19687146_ChIP-ChIP_HELA_Human1.11171456
58MAF_26560356_Chip-Seq_TH1_Human1.11137166
59FOXA1_25329375_ChIP-Seq_VCAP_Human1.10819536
60FOXA1_27270436_Chip-Seq_PROSTATE_Human1.10819536
61STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.10603104
62YY1_22570637_ChIP-Seq_MALME-3M_Human1.09262794
63TAF2_19829295_ChIP-Seq_ESCs_Human1.08223938
64POU5F1_16153702_ChIP-ChIP_HESCs_Human1.08108743
65ELF1_20517297_ChIP-Seq_JURKAT_Human1.07503356
66ERG_20517297_ChIP-Seq_VCAP_Human1.06470384
67FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.05962921
68ER_23166858_ChIP-Seq_MCF-7_Human1.05463308
69FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04523084
70EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.04375377
71LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.03253618
72MYC_18940864_ChIP-ChIP_HL60_Human1.03156668
73NANOG_19829295_ChIP-Seq_ESCs_Human1.02586621
74SOX2_19829295_ChIP-Seq_ESCs_Human1.02586621
75SCL_19346495_ChIP-Seq_HPC-7_Human1.02556472
76CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.01024361
77YY1_21170310_ChIP-Seq_MESCs_Mouse1.00458424
78BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99557861
79NCOR_22424771_ChIP-Seq_293T_Human0.99415836
80GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.98824151
81SPI1_23547873_ChIP-Seq_NB4_Human0.97439380
82EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97343624
83RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.96345523
84GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95470009
85FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94984608
86CTBP2_25329375_ChIP-Seq_LNCAP_Human0.94952197
87MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.93649564
88EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.93105597
89MYC_19829295_ChIP-Seq_ESCs_Human0.92948425
90AUTS2_25519132_ChIP-Seq_293T-REX_Human0.89997415
91CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.89755560
92NFE2_27457419_Chip-Seq_LIVER_Mouse0.89482641
93ETV2_25802403_ChIP-Seq_MESCs_Mouse0.89377585
94EWS_26573619_Chip-Seq_HEK293_Human0.88071239
95POU3F2_20337985_ChIP-ChIP_501MEL_Human0.87555210
96VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.87367630
97GATA3_21878914_ChIP-Seq_MCF-7_Human0.85908346
98FOXH1_21741376_ChIP-Seq_EPCs_Human0.85711477
99TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.85060278
100PCGF2_27294783_Chip-Seq_NPCs_Mouse0.85042582

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.98384307
2MP0009785_altered_susceptibility_to3.69085436
3MP0003763_abnormal_thymus_physiology3.47096736
4MP0002166_altered_tumor_susceptibility3.06212029
5MP0002102_abnormal_ear_morphology3.01263915
6MP0001835_abnormal_antigen_presentation2.92033085
7MP0009333_abnormal_splenocyte_physiolog2.45852712
8MP0002006_tumorigenesis2.44239151
9MP0005000_abnormal_immune_tolerance2.41666427
10MP0005645_abnormal_hypothalamus_physiol2.23748216
11MP0005025_abnormal_response_to2.16608254
12MP0001800_abnormal_humoral_immune2.16533628
13MP0003866_abnormal_defecation2.04496477
14MP0002420_abnormal_adaptive_immunity1.98074522
15MP0002148_abnormal_hypersensitivity_rea1.94913755
16MP0002723_abnormal_immune_serum1.93394974
17MP0009379_abnormal_foot_pigmentation1.92521753
18MP0001819_abnormal_immune_cell1.89281797
19MP0000685_abnormal_immune_system1.88615142
20MP0004147_increased_porphyrin_level1.85747944
21MP0006082_CNS_inflammation1.84622897
22MP0001790_abnormal_immune_system1.84308173
23MP0005387_immune_system_phenotype1.84308173
24MP0005377_hearing/vestibular/ear_phenot1.83535654
25MP0003878_abnormal_ear_physiology1.83535654
26MP0005464_abnormal_platelet_physiology1.69846192
27MP0008872_abnormal_physiological_respon1.68381973
28MP0001873_stomach_inflammation1.68230095
29MP0002405_respiratory_system_inflammati1.65962208
30MP0002398_abnormal_bone_marrow1.63620462
31MP0010155_abnormal_intestine_physiology1.60857152
32MP0003646_muscle_fatigue1.60167453
33MP0000716_abnormal_immune_system1.57449970
34MP0002452_abnormal_antigen_presenting1.56405276
35MP0001905_abnormal_dopamine_level1.49792219
36MP0002837_dystrophic_cardiac_calcinosis1.46256821
37MP0005075_abnormal_melanosome_morpholog1.40674741
38MP0004885_abnormal_endolymph1.37802461
39MP0000703_abnormal_thymus_morphology1.36960129
40MP0002722_abnormal_immune_system1.36839876
41MP0001485_abnormal_pinna_reflex1.35820147
42MP0002933_joint_inflammation1.35663426
43MP0004145_abnormal_muscle_electrophysio1.34153122
44MP0001188_hyperpigmentation1.30395215
45MP0000689_abnormal_spleen_morphology1.28705389
46MP0005551_abnormal_eye_electrophysiolog1.24447635
47MP0008875_abnormal_xenobiotic_pharmacok1.23771401
48MP0003045_fibrosis1.22944278
49MP0001764_abnormal_homeostasis1.22219323
50MP0002876_abnormal_thyroid_physiology1.20800456
51MP0001845_abnormal_inflammatory_respons1.20254705
52MP0001661_extended_life_span1.20051468
53MP0003880_abnormal_central_pattern1.18675547
54MP0002095_abnormal_skin_pigmentation1.18432100
55MP0002429_abnormal_blood_cell1.17234004
56MP0002419_abnormal_innate_immunity1.13082257
57MP0005646_abnormal_pituitary_gland1.11895454
58MP0002277_abnormal_respiratory_mucosa1.11837403
59MP0000681_abnormal_thyroid_gland1.07091942
60MP0006072_abnormal_retinal_apoptosis1.04664273
61MP0003448_altered_tumor_morphology1.02900202
62MP0005389_reproductive_system_phenotype1.00954444
63MP0003436_decreased_susceptibility_to1.00081882
64MP0002160_abnormal_reproductive_system0.99802274
65MP0001529_abnormal_vocalization0.99644468
66MP0008995_early_reproductive_senescence0.99561117
67MP0005174_abnormal_tail_pigmentation0.99470687
68MP0003786_premature_aging0.97909783
69MP0002132_abnormal_respiratory_system0.97909386
70MP0008469_abnormal_protein_level0.96454002
71MP0002653_abnormal_ependyma_morphology0.90344530
72MP0005166_decreased_susceptibility_to0.87653674
73MP0006036_abnormal_mitochondrial_physio0.85695941
74MP0002736_abnormal_nociception_after0.85154677
75MP0010386_abnormal_urinary_bladder0.85153326
76MP0000678_abnormal_parathyroid_gland0.84861650
77MP0001919_abnormal_reproductive_system0.82435238
78MP0001968_abnormal_touch/_nociception0.81536903
79MP0003724_increased_susceptibility_to0.76858460
80MP0000465_gastrointestinal_hemorrhage0.76566782
81MP0008789_abnormal_olfactory_epithelium0.75602525
82MP0001533_abnormal_skeleton_physiology0.74054790
83MP0009763_increased_sensitivity_to0.72874001
84MP0004036_abnormal_muscle_relaxation0.72701720
85MP0002138_abnormal_hepatobiliary_system0.72504999
86MP0002234_abnormal_pharynx_morphology0.71616396
87MP0006276_abnormal_autonomic_nervous0.71366778
88MP0009764_decreased_sensitivity_to0.71007415
89MP0002019_abnormal_tumor_incidence0.70897885
90MP0001664_abnormal_digestion0.69835091
91MP0002638_abnormal_pupillary_reflex0.69665833
92MP0004043_abnormal_pH_regulation0.69150827
93MP0001501_abnormal_sleep_pattern0.68938491
94MP0003137_abnormal_impulse_conducting0.68803548
95MP0000372_irregular_coat_pigmentation0.68474025
96MP0004947_skin_inflammation0.67313487
97MP0002693_abnormal_pancreas_physiology0.66033328
98MP0003075_altered_response_to0.65793850
99MP0003252_abnormal_bile_duct0.64895820
100MP0005636_abnormal_mineral_homeostasis0.64263116

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)5.84159845
2Severe combined immunodeficiency (HP:0004430)5.37386856
3Abnormality of B cell number (HP:0010975)5.32165045
4Hypoproteinemia (HP:0003075)5.14189439
5T lymphocytopenia (HP:0005403)5.13609140
6Abnormality of T cell number (HP:0011839)4.95369092
7B lymphocytopenia (HP:0010976)4.84166441
8Thyroiditis (HP:0100646)4.66470636
9Absent rod-and cone-mediated responses on ERG (HP:0007688)4.55699700
10Autoimmune hemolytic anemia (HP:0001890)4.21830458
11Combined immunodeficiency (HP:0005387)4.20360885
12Elevated erythrocyte sedimentation rate (HP:0003565)3.77961204
13IgG deficiency (HP:0004315)3.77813535
14Abnormal rod and cone electroretinograms (HP:0008323)3.74855945
15Increased IgM level (HP:0003496)3.46091827
16Congenital stationary night blindness (HP:0007642)3.45030101
17Abnormality of eosinophils (HP:0001879)3.44296809
18Mitochondrial inheritance (HP:0001427)3.35178667
19Abnormality of T cells (HP:0002843)3.25086578
20Hepatocellular necrosis (HP:0001404)3.17531407
21Attenuation of retinal blood vessels (HP:0007843)2.98843960
22Reduced antithrombin III activity (HP:0001976)2.97348447
23Hypoplasia of the thymus (HP:0000778)2.94954179
24Abnormality of the prostate (HP:0008775)2.88039242
25Eosinophilia (HP:0001880)2.87749454
26Hepatic necrosis (HP:0002605)2.84179775
27Increased intramyocellular lipid droplets (HP:0012240)2.82107198
28Acute necrotizing encephalopathy (HP:0006965)2.79059321
29Abnormality of macular pigmentation (HP:0008002)2.74561813
30Autoimmune thrombocytopenia (HP:0001973)2.71779373
31Severe visual impairment (HP:0001141)2.69557014
323-Methylglutaconic aciduria (HP:0003535)2.67646898
33Abolished electroretinogram (ERG) (HP:0000550)2.66448612
34Leukocytosis (HP:0001974)2.64102784
35Abnormal mitochondria in muscle tissue (HP:0008316)2.63757322
36Constricted visual fields (HP:0001133)2.63678161
37Increased CSF lactate (HP:0002490)2.54118043
38Decreased central vision (HP:0007663)2.48975505
39Amyotrophic lateral sclerosis (HP:0007354)2.46788815
40Generalized aminoaciduria (HP:0002909)2.45036044
41Pustule (HP:0200039)2.42694471
42Increased hepatocellular lipid droplets (HP:0006565)2.37919400
43Central scotoma (HP:0000603)2.35084044
44Renal Fanconi syndrome (HP:0001994)2.31665200
45Optic disc pallor (HP:0000543)2.28487216
46Panhypogammaglobulinemia (HP:0003139)2.27540051
47Lymphopenia (HP:0001888)2.26867777
48Chronic diarrhea (HP:0002028)2.23501102
49Encephalitis (HP:0002383)2.22929558
50Decreased activity of mitochondrial respiratory chain (HP:0008972)2.22271742
51Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.22271742
52Progressive macrocephaly (HP:0004481)2.21835723
53Abnormal albumin level (HP:0012116)2.21198380
54Hypoalbuminemia (HP:0003073)2.21198380
55Increased muscle lipid content (HP:0009058)2.19878824
56Granulocytopenia (HP:0001913)2.19460845
57Meningitis (HP:0001287)2.18881877
58Dyschromatopsia (HP:0007641)2.17759179
59Abnormality of cells of the lymphoid lineage (HP:0012140)2.15902293
60Acute encephalopathy (HP:0006846)2.12029872
61Pancreatic cysts (HP:0001737)2.11822602
62Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.05598492
63Abnormal protein N-linked glycosylation (HP:0012347)2.05598492
64Abnormal protein glycosylation (HP:0012346)2.05598492
65Abnormal glycosylation (HP:0012345)2.05598492
66Abnormal delayed hypersensitivity skin test (HP:0002963)2.04352719
67Abnormality of midbrain morphology (HP:0002418)2.01598150
68Molar tooth sign on MRI (HP:0002419)2.01598150
69Decreased electroretinogram (ERG) amplitude (HP:0000654)1.99930142
70Exertional dyspnea (HP:0002875)1.99628605
71True hermaphroditism (HP:0010459)1.99378446
72Lymphoma (HP:0002665)1.97385367
73Pancytopenia (HP:0001876)1.96932931
74Methylmalonic acidemia (HP:0002912)1.94906934
75Lipid accumulation in hepatocytes (HP:0006561)1.94439653
76Obstructive lung disease (HP:0006536)1.93614643
77Chronic obstructive pulmonary disease (HP:0006510)1.93614643
78Ketosis (HP:0001946)1.92972681
79Abnormality of macrophages (HP:0004311)1.90427752
80Recurrent fungal infections (HP:0002841)1.89390446
81Cerebral palsy (HP:0100021)1.88908961
82Cerebral edema (HP:0002181)1.88812693
83Type I transferrin isoform profile (HP:0003642)1.87968769
84Increased serum lactate (HP:0002151)1.87175724
85Abnormal number of erythroid precursors (HP:0012131)1.86939014
86Gastrointestinal infarctions (HP:0005244)1.86250877
87Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.86211953
88Abnormal drinking behavior (HP:0030082)1.83905534
89Polydipsia (HP:0001959)1.83905534
90Recurrent viral infections (HP:0004429)1.81603328
91Renal cortical cysts (HP:0000803)1.81433788
92IgM deficiency (HP:0002850)1.81255376
93Hypergammaglobulinemia (HP:0010702)1.79718471
94Chest pain (HP:0100749)1.77024022
95Pancreatic fibrosis (HP:0100732)1.75197787
96Type 2 muscle fiber atrophy (HP:0003554)1.74827655
97Methylmalonic aciduria (HP:0012120)1.74136831
98Oral leukoplakia (HP:0002745)1.73668279
99Abnormality of cells of the erythroid lineage (HP:0012130)1.73421331
100Lactic acidosis (HP:0003128)1.72998977

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR6.23437462
2TXK4.79577659
3TESK24.35616157
4BCKDK4.06096156
5MAP4K13.12901078
6VRK23.07588944
7ITK2.13929224
8TAOK32.13338113
9MAP3K122.03144837
10CDK191.97668799
11TESK11.89379754
12MAP3K111.82541965
13LIMK11.82541885
14GRK61.78053846
15ZAK1.76402376
16SCYL21.70759459
17ADRBK21.70449776
18VRK11.70238957
19SYK1.65912862
20KIT1.55504085
21MUSK1.44885807
22PASK1.42107986
23MAP4K21.41351125
24GRK11.39592902
25DAPK11.38613423
26TEC1.36677171
27TRPM71.33690801
28PINK11.25584093
29TLK11.23595748
30FES1.17474855
31CSF1R1.04710998
32BUB11.03954285
33BTK1.03694253
34LCK1.03421960
35TIE11.00673776
36EIF2AK30.99822609
37DAPK20.94528663
38ZAP700.93916998
39PRKCQ0.93840372
40NME10.93814342
41GRK70.88225102
42CAMKK10.87155752
43RPS6KA40.86628299
44CSK0.82651822
45CAMKK20.82115530
46LYN0.80697778
47FRK0.80464559
48PIK3CG0.79247276
49INSRR0.79191939
50NUAK10.79156328
51MYLK0.77402580
52MAP3K50.76090712
53JAK30.74327041
54RPS6KA50.68517102
55MAP2K70.67417816
56OBSCN0.64934398
57CSNK1G30.62614532
58BCR0.61764037
59MAPKAPK30.61747983
60IGF1R0.60125139
61FYN0.58552809
62DAPK30.57608219
63TRIM280.56928026
64ADRBK10.55054856
65TBK10.54307437
66OXSR10.52145974
67TNK20.51292491
68DYRK20.50879829
69HCK0.49380221
70MATK0.46887283
71PIK3CA0.46258855
72WNK40.44217365
73MAPK130.43072882
74FLT30.42282765
75ROCK10.41621401
76ERBB30.41345483
77CDK30.40838790
78WNK30.39947206
79PRKCA0.39442312
80CSNK1A1L0.39014418
81PRKCH0.38851290
82CSNK1G20.38799757
83CSNK1G10.37862957
84ABL10.34518809
85MAP3K40.34064485
86ILK0.33461203
87BMPR1B0.33048292
88IKBKE0.33031514
89PIM10.31845259
90PRKACA0.31748848
91AURKA0.31384200
92STK160.31095560
93CSNK2A10.30863866
94GRK50.30803167
95MAP2K60.30562238
96MAPKAPK50.29229363
97MST40.28584615
98INSR0.26493519
99CSNK1A10.25088948
100IKBKB0.24956862

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.54002464
2Proteasome_Homo sapiens_hsa030504.34923588
3Antigen processing and presentation_Homo sapiens_hsa046123.00536455
4Graft-versus-host disease_Homo sapiens_hsa053322.99347385
5Oxidative phosphorylation_Homo sapiens_hsa001902.93969754
6Allograft rejection_Homo sapiens_hsa053302.87261499
7Hematopoietic cell lineage_Homo sapiens_hsa046402.73646009
8Autoimmune thyroid disease_Homo sapiens_hsa053202.60631063
9Parkinsons disease_Homo sapiens_hsa050122.55016018
10Type I diabetes mellitus_Homo sapiens_hsa049402.52381707
11Ribosome_Homo sapiens_hsa030102.40025654
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.15931490
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.13434634
14Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.04963096
15Caffeine metabolism_Homo sapiens_hsa002322.04865581
16T cell receptor signaling pathway_Homo sapiens_hsa046601.96589016
17RNA polymerase_Homo sapiens_hsa030201.78200768
18Alzheimers disease_Homo sapiens_hsa050101.70748613
19Phototransduction_Homo sapiens_hsa047441.61327194
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.59197885
21Rheumatoid arthritis_Homo sapiens_hsa053231.57468389
22Huntingtons disease_Homo sapiens_hsa050161.54396683
23Protein export_Homo sapiens_hsa030601.50798418
24Cardiac muscle contraction_Homo sapiens_hsa042601.50567953
25Malaria_Homo sapiens_hsa051441.41273478
26Asthma_Homo sapiens_hsa053101.23858921
27Measles_Homo sapiens_hsa051621.20685023
28Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.19588074
29Viral myocarditis_Homo sapiens_hsa054161.19214501
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.18981012
31Nitrogen metabolism_Homo sapiens_hsa009101.16848245
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.09656946
33Salmonella infection_Homo sapiens_hsa051321.09224852
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.07585944
35Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.05507702
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.01550254
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01246992
38Shigellosis_Homo sapiens_hsa051310.97684029
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.96737589
40Primary bile acid biosynthesis_Homo sapiens_hsa001200.88586992
41SNARE interactions in vesicular transport_Homo sapiens_hsa041300.87938200
42NF-kappa B signaling pathway_Homo sapiens_hsa040640.86126368
43Butanoate metabolism_Homo sapiens_hsa006500.85338189
44Olfactory transduction_Homo sapiens_hsa047400.84346663
45Systemic lupus erythematosus_Homo sapiens_hsa053220.83153651
46Pyrimidine metabolism_Homo sapiens_hsa002400.82747021
47NOD-like receptor signaling pathway_Homo sapiens_hsa046210.80977735
48Purine metabolism_Homo sapiens_hsa002300.80626064
49Retinol metabolism_Homo sapiens_hsa008300.78156725
50RNA degradation_Homo sapiens_hsa030180.77104363
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76021751
52Peroxisome_Homo sapiens_hsa041460.74123206
53African trypanosomiasis_Homo sapiens_hsa051430.73758055
54Linoleic acid metabolism_Homo sapiens_hsa005910.71506358
55Chemical carcinogenesis_Homo sapiens_hsa052040.68684742
56Drug metabolism - other enzymes_Homo sapiens_hsa009830.68254813
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67687956
58Regulation of autophagy_Homo sapiens_hsa041400.66782746
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66390810
60RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.63145057
61Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.60688438
62Herpes simplex infection_Homo sapiens_hsa051680.60601888
63Legionellosis_Homo sapiens_hsa051340.57773606
64Selenocompound metabolism_Homo sapiens_hsa004500.57316464
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56101612
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53203116
67N-Glycan biosynthesis_Homo sapiens_hsa005100.52888200
68Staphylococcus aureus infection_Homo sapiens_hsa051500.52603689
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51288322
70Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.51150918
71Nicotine addiction_Homo sapiens_hsa050330.48245909
72Toll-like receptor signaling pathway_Homo sapiens_hsa046200.47324540
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47284392
74Taste transduction_Homo sapiens_hsa047420.45588326
75Salivary secretion_Homo sapiens_hsa049700.44250824
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42080178
77Leishmaniasis_Homo sapiens_hsa051400.40624235
78Propanoate metabolism_Homo sapiens_hsa006400.36756354
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.36606506
80Metabolic pathways_Homo sapiens_hsa011000.35764020
81Pertussis_Homo sapiens_hsa051330.34714386
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34582481
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.33796238
84Nucleotide excision repair_Homo sapiens_hsa034200.33597810
85Fanconi anemia pathway_Homo sapiens_hsa034600.33469299
86Spliceosome_Homo sapiens_hsa030400.33079554
87Jak-STAT signaling pathway_Homo sapiens_hsa046300.31349516
88Tryptophan metabolism_Homo sapiens_hsa003800.31086227
89Arachidonic acid metabolism_Homo sapiens_hsa005900.29884494
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27588743
91Maturity onset diabetes of the young_Homo sapiens_hsa049500.26878450
92ABC transporters_Homo sapiens_hsa020100.25197969
93Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.23741446
94Epstein-Barr virus infection_Homo sapiens_hsa051690.23607983
95Collecting duct acid secretion_Homo sapiens_hsa049660.23442277
96Mineral absorption_Homo sapiens_hsa049780.19459574
97Homologous recombination_Homo sapiens_hsa034400.18452283
98Chemokine signaling pathway_Homo sapiens_hsa040620.18369721
99Ether lipid metabolism_Homo sapiens_hsa005650.17988909
100Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.17907583

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