BTG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of an anti-proliferative gene family that regulates cell growth and differentiation. Expression of this gene is highest in the G0/G1 phases of the cell cycle and downregulated when cells progressed through G1. The encoded protein interacts with several nuclear receptors, and functions as a coactivator of cell differentiation. This locus has been shown to be involved in a t(8;12)(q24;q22) chromosomal translocation in a case of B-cell chronic lymphocytic leukemia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.67074117
2neutrophil activation involved in immune response (GO:0002283)5.38949958
3positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.04329142
4regulation of B cell receptor signaling pathway (GO:0050855)4.96603037
5tolerance induction (GO:0002507)4.91246809
6regulation of gamma-delta T cell activation (GO:0046643)4.65107022
7neutrophil activation (GO:0042119)4.46977135
8positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.41802386
9regulation of gamma-delta T cell differentiation (GO:0045586)4.41244403
10granulocyte activation (GO:0036230)4.30046066
11myeloid dendritic cell differentiation (GO:0043011)4.14490913
12response to peptidoglycan (GO:0032494)4.09027732
13regulation of T-helper 1 cell differentiation (GO:0045625)4.03622808
14positive regulation of alpha-beta T cell proliferation (GO:0046641)4.02970404
15regulation of activation of Janus kinase activity (GO:0010533)4.02698965
16T cell migration (GO:0072678)4.00655617
17positive thymic T cell selection (GO:0045059)3.98998859
18response to muramyl dipeptide (GO:0032495)3.98723789
19response to interleukin-15 (GO:0070672)3.96944084
20myeloid dendritic cell activation (GO:0001773)3.96802595
21negative regulation of T cell mediated immunity (GO:0002710)3.95826428
22cellular response to interleukin-15 (GO:0071350)3.95315460
23positive regulation of interleukin-12 production (GO:0032735)3.93269953
24regulation of dendritic cell antigen processing and presentation (GO:0002604)3.86194867
25regulation of interleukin-12 biosynthetic process (GO:0045075)3.81824961
26negative regulation of lymphocyte mediated immunity (GO:0002707)3.80664723
27positive regulation of type 2 immune response (GO:0002830)3.77501961
28positive T cell selection (GO:0043368)3.76901789
29regulation of alpha-beta T cell proliferation (GO:0046640)3.74095440
30thymic T cell selection (GO:0045061)3.72481862
31positive regulation of gamma-delta T cell activation (GO:0046645)3.72252680
32T cell selection (GO:0045058)3.70159809
33positive regulation of monocyte chemotaxis (GO:0090026)3.68014821
34regulation of regulatory T cell differentiation (GO:0045589)3.60867490
35detection of other organism (GO:0098543)3.60708181
36T-helper 1 type immune response (GO:0042088)3.59528541
37positive regulation of interleukin-2 production (GO:0032743)3.59025336
38positive regulation of interferon-alpha production (GO:0032727)3.58345501
39detection of bacterium (GO:0016045)3.57082551
40regulation of tolerance induction (GO:0002643)3.56925583
41negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.54939499
42negative regulation of cell killing (GO:0031342)3.54939499
43positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.52503344
44negative regulation of interleukin-12 production (GO:0032695)3.51639337
45NIK/NF-kappaB signaling (GO:0038061)3.51403906
46positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.51280439
47negative thymic T cell selection (GO:0045060)3.51176201
48B cell receptor signaling pathway (GO:0050853)3.50267632
49immunoglobulin mediated immune response (GO:0016064)3.47467880
50activated T cell proliferation (GO:0050798)3.46600694
51negative T cell selection (GO:0043383)3.46058051
52antigen processing and presentation of endogenous antigen (GO:0019883)3.43413908
53positive regulation of antigen processing and presentation (GO:0002579)3.43303012
54regulation of T cell mediated cytotoxicity (GO:0001914)3.42218389
55positive regulation of isotype switching (GO:0045830)3.41502169
56regulation of RIG-I signaling pathway (GO:0039535)3.41283516
57interferon-gamma-mediated signaling pathway (GO:0060333)3.40929217
58lipopolysaccharide-mediated signaling pathway (GO:0031663)3.40815433
59regulation of interferon-alpha production (GO:0032647)3.40535993
60regulation of immunoglobulin secretion (GO:0051023)3.39962691
61positive regulation of T-helper cell differentiation (GO:0045624)3.39458227
62cellular response to zinc ion (GO:0071294)3.38772247
63regulation of T-helper 2 cell differentiation (GO:0045628)3.38384915
64monocyte chemotaxis (GO:0002548)3.38192533
65type I interferon signaling pathway (GO:0060337)3.36624526
66cellular response to type I interferon (GO:0071357)3.36624526
67negative regulation of leukocyte mediated immunity (GO:0002704)3.36171481
68regulation of natural killer cell mediated immunity (GO:0002715)3.36087201
69regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.36087201
70superoxide anion generation (GO:0042554)3.34815630
71positive regulation of mast cell activation (GO:0033005)3.34002783
72response to type I interferon (GO:0034340)3.33906236
73positive regulation of cellular amide metabolic process (GO:0034250)3.32581598
74hydrogen peroxide biosynthetic process (GO:0050665)3.31389182
75positive regulation of immunoglobulin mediated immune response (GO:0002891)3.29727892
76positive regulation of B cell mediated immunity (GO:0002714)3.29727892
77interferon-gamma production (GO:0032609)3.28756424
78regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.25703823
79defense response to protozoan (GO:0042832)3.25633724
80respiratory burst (GO:0045730)3.25485599
81regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.24369775
82regulation of B cell differentiation (GO:0045577)3.24055747
83positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.23971499
84eosinophil chemotaxis (GO:0048245)3.23566868
85dendritic cell chemotaxis (GO:0002407)3.23395319
86regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.21966557
87regulation of hypersensitivity (GO:0002883)3.20874627
88positive regulation of T cell mediated cytotoxicity (GO:0001916)3.20284456
89positive regulation of natural killer cell differentiation (GO:0032825)3.20246911
90cellular extravasation (GO:0045123)3.19762608
91positive regulation of DNA recombination (GO:0045911)3.18493032
92positive regulation of tolerance induction (GO:0002645)3.17051642
93negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.14354710
94regulation of interleukin-2 biosynthetic process (GO:0045076)3.13788051
95natural killer cell mediated immunity (GO:0002228)3.13605130
96natural killer cell mediated cytotoxicity (GO:0042267)3.13605130
97positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.13421442
98dendritic cell differentiation (GO:0097028)3.11402378
99regulation of interleukin-12 production (GO:0032655)3.10833063
100regulation of leukocyte mediated cytotoxicity (GO:0001910)3.08985443
101antigen receptor-mediated signaling pathway (GO:0050851)3.07816387
102modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.07292287
103modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.07292287
104positive regulation by organism of defense response of other organism involved in symbiotic interact3.07292287
105modulation by symbiont of host immune response (GO:0052553)3.07292287
106positive regulation by symbiont of host defense response (GO:0052509)3.07292287
107modulation by symbiont of host defense response (GO:0052031)3.07292287
108CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.06154289
109T-helper cell differentiation (GO:0042093)3.06154289
110leukocyte aggregation (GO:0070486)3.05066211
111regulation of interferon-beta biosynthetic process (GO:0045357)3.02007490
112positive regulation of B cell differentiation (GO:0045579)3.01298123
113positive regulation of response to biotic stimulus (GO:0002833)2.99584899
114T cell receptor signaling pathway (GO:0050852)2.99513701
115regulation of isotype switching to IgG isotypes (GO:0048302)2.99364651
116mast cell activation (GO:0045576)2.98779705
117positive regulation of mast cell degranulation (GO:0043306)2.98595554
118positive regulation of mast cell activation involved in immune response (GO:0033008)2.98595554
119regulation of T-helper cell differentiation (GO:0045622)2.98450141
120positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.98239950
121regulation of chronic inflammatory response (GO:0002676)2.97830261
122negative regulation of innate immune response (GO:0045824)2.97513405
123positive regulation of humoral immune response (GO:0002922)2.97278036
124negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.97244981
125B cell homeostasis (GO:0001782)2.96710964
126regulation of cell killing (GO:0031341)2.96150235
127regulation of antigen processing and presentation (GO:0002577)2.93857846
128regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.93680448
129negative regulation of interleukin-17 production (GO:0032700)2.92860690
130dendritic cell migration (GO:0036336)2.91254585
131cellular response to interferon-beta (GO:0035458)2.90755625
132response to protozoan (GO:0001562)2.90398116
133regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.89876483
134germinal center formation (GO:0002467)2.89551224
135regulation of alpha-beta T cell activation (GO:0046634)2.88676295
136macrophage activation involved in immune response (GO:0002281)2.88172986
137antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.87524671
138antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.87524671
139natural killer cell activation (GO:0030101)2.87404707
140reactive oxygen species biosynthetic process (GO:1903409)2.87075823
141T cell activation involved in immune response (GO:0002286)2.86920629
142myeloid leukocyte activation (GO:0002274)2.85629208
143regulation of T cell tolerance induction (GO:0002664)2.85612063
144T cell costimulation (GO:0031295)2.85406328
145positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.85274864
146regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.85162004
147regulation of T-helper 1 type immune response (GO:0002825)2.84074739
148detection of external biotic stimulus (GO:0098581)2.83798130
149negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.83778616
150negative regulation of T-helper cell differentiation (GO:0045623)2.83758580
151negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.83758580
152eosinophil migration (GO:0072677)2.82925485
153regulation of mononuclear cell migration (GO:0071675)2.82824751
154regulation of germinal center formation (GO:0002634)2.82363427

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.82945836
2BP1_19119308_ChIP-ChIP_Hs578T_Human6.29475054
3IRF8_21731497_ChIP-ChIP_J774_Mouse5.94773371
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.87744505
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.54731100
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.25397971
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.90952036
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.76399939
9* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.54540676
10* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.49883551
11RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.34401286
12* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.14922938
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.10772215
14STAT4_19710469_ChIP-ChIP_TH1__Mouse2.88541670
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.78234984
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.68523648
17TP63_17297297_ChIP-ChIP_HaCaT_Human2.52657018
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.48069799
19* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.38865861
20* RUNX_20019798_ChIP-Seq_JUKART_Human2.36849508
21SMAD_19615063_ChIP-ChIP_OVARY_Human2.33813918
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.17384239
23* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.05463158
24* MYB_26560356_Chip-Seq_TH2_Human1.99536985
25MYC_22102868_ChIP-Seq_BL_Human1.98057889
26STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.93612730
27VDR_21846776_ChIP-Seq_THP-1_Human1.91787922
28* VDR_24787735_ChIP-Seq_THP-1_Human1.87750858
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.81660291
30* SPI1_23547873_ChIP-Seq_NB4_Human1.74807333
31* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.67545773
32TCF7_22412390_ChIP-Seq_EML_Mouse1.65722301
33PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.61152465
34KDM2B_26808549_Chip-Seq_SUP-B15_Human1.58723495
35PU_27001747_Chip-Seq_BMDM_Mouse1.54864851
36BRD4_27068464_Chip-Seq_AML-cells_Mouse1.54196447
37* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.53998916
38NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.53196955
39* MYB_26560356_Chip-Seq_TH1_Human1.51347639
40VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.47538813
41MAF_26560356_Chip-Seq_TH1_Human1.46205724
42BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.46120917
43KDM2B_26808549_Chip-Seq_DND41_Human1.42960905
44CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.42214395
45* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.38799376
46VDR_24763502_ChIP-Seq_THP-1_Human1.32812601
47RUNX1_22412390_ChIP-Seq_EML_Mouse1.32535254
48* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.31005107
49SCL_19346495_ChIP-Seq_HPC-7_Human1.29745725
50* GATA3_27048872_Chip-Seq_THYMUS_Human1.27585863
51* GATA3_26560356_Chip-Seq_TH2_Human1.24813785
52* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21257233
53* GATA2_21666600_ChIP-Seq_HMVEC_Human1.20035038
54* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.19741275
55NOTCH1_21737748_ChIP-Seq_TLL_Human1.19473934
56* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.16098271
57CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13145011
58PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13144450
59* KDM2B_26808549_Chip-Seq_JURKAT_Human1.11168619
60THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.10764482
61TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08455204
62* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.05034020
63CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.04778579
64ELF1_17652178_ChIP-ChIP_JURKAT_Human1.04575453
65* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.04376260
66RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.04146997
67* SPI1_23127762_ChIP-Seq_K562_Human1.03847215
68* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.03310985
69* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.03310985
70* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.02481253
71* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.02481253
72TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.00298423
73GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99633992
74LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.98131003
75* GATA1_19941827_ChIP-Seq_MEL_Mouse0.95994155
76SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95909765
77CJUN_26792858_Chip-Seq_BT549_Human0.95768775
78CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.95760962
79CDX2_19796622_ChIP-Seq_MESCs_Mouse0.95024086
80TRIM28_21343339_ChIP-Seq_HEK293_Human0.94695322
81GATA1_19941826_ChIP-Seq_K562_Human0.93708170
82SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.93590235
83FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.92271293
84VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.91333962
85CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.91269797
86NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.88743617
87* SOX2_20726797_ChIP-Seq_SW620_Human0.87340053
88STAT6_21828071_ChIP-Seq_BEAS2B_Human0.86482264
89SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86094595
90CIITA_25753668_ChIP-Seq_RAJI_Human0.85327723
91* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.84574849
92FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.84455616
93SMRT_27268052_Chip-Seq_Bcells_Human0.84340173
94* ELK3_25401928_ChIP-Seq_HUVEC_Human0.84221557
95FLI1_27457419_Chip-Seq_LIVER_Mouse0.83863945
96EGR1_19032775_ChIP-ChIP_M12_Human0.83862916
97GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83766904
98GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.83376305
99* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82904147
100IKZF1_21737484_ChIP-ChIP_HCT116_Human0.82348707
101RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.82025065
102LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.80813035
103* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78274166
104* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.77990633
105PU.1_20513432_ChIP-Seq_Bcells_Mouse0.77074680
106CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.76463428
107* CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.76384405
108BCL6_27268052_Chip-Seq_Bcells_Human0.74792614
109GATA2_19941826_ChIP-Seq_K562_Human0.73767616
110E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.72852771
111UTX_26944678_Chip-Seq_JUKART_Human0.72213515
112CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.71312183
113PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.71299590
114FOXO3_23340844_ChIP-Seq_DLD1_Human0.71175543
115PCGF2_27294783_Chip-Seq_ESCs_Mouse0.71018143
116GATA1_22383799_ChIP-Seq_G1ME_Mouse0.70886367
117TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.70565823
118* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.70414802
119* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.70186048
120* TP53_18474530_ChIP-ChIP_U2OS_Human0.69815888
121* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.68145716
122MAF_26560356_Chip-Seq_TH2_Human0.65107534
123BCOR_27268052_Chip-Seq_Bcells_Human0.64060306
124PU1_27457419_Chip-Seq_LIVER_Mouse0.60038841
125NMYC_18555785_Chip-Seq_ESCs_Mouse0.59698000
126GATA1_22025678_ChIP-Seq_K562_Human0.59441076
127* EZH2_27294783_Chip-Seq_NPCs_Mouse0.58932551
128GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.58222064
129PPAR_26484153_Chip-Seq_NCI-H1993_Human0.58142285
130RXR_22108803_ChIP-Seq_LS180_Human0.57684668
131KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.57601146

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.19465093
2MP0002148_abnormal_hypersensitivity_rea4.25855537
3MP0009785_altered_susceptibility_to3.92644484
4MP0003436_decreased_susceptibility_to3.78091602
5MP0005671_abnormal_response_to3.64078117
6MP0005000_abnormal_immune_tolerance3.33645458
7MP0000685_abnormal_immune_system3.28552161
8MP0001790_abnormal_immune_system3.26149704
9MP0005387_immune_system_phenotype3.26149704
10MP0006082_CNS_inflammation2.92246683
11MP0002419_abnormal_innate_immunity2.86821250
12MP0005025_abnormal_response_to2.85363818
13MP0003724_increased_susceptibility_to2.74677804
14MP0002452_abnormal_antigen_presenting2.74219764
15MP0001800_abnormal_humoral_immune2.66983392
16MP0002723_abnormal_immune_serum2.63223209
17MP0001819_abnormal_immune_cell2.43477382
18MP0002420_abnormal_adaptive_immunity2.39781270
19MP0004510_myositis2.35826916
20MP0002006_tumorigenesis2.32055469
21MP0001853_heart_inflammation2.17604401
22MP0002405_respiratory_system_inflammati2.15608839
23MP0002163_abnormal_gland_morphology2.03649852
24MP0003763_abnormal_thymus_physiology1.99531534
25MP0002138_abnormal_hepatobiliary_system1.96694492
26MP0005310_abnormal_salivary_gland1.95557802
27MP0003303_peritoneal_inflammation1.95453230
28MP0002166_altered_tumor_susceptibility1.92633272
29MP0000465_gastrointestinal_hemorrhage1.85715606
30MP0009764_decreased_sensitivity_to1.84977189
31MP0010155_abnormal_intestine_physiology1.84142118
32MP0001533_abnormal_skeleton_physiology1.82552675
33MP0001845_abnormal_inflammatory_respons1.81666598
34MP0003448_altered_tumor_morphology1.81538871
35MP0000716_abnormal_immune_system1.75225896
36MP0002254_reproductive_system_inflammat1.73217245
37MP0009333_abnormal_splenocyte_physiolog1.71345541
38MP0002277_abnormal_respiratory_mucosa1.70695983
39MP0004947_skin_inflammation1.68644809
40MP0002398_abnormal_bone_marrow1.66335663
41MP0000858_altered_metastatic_potential1.60686999
42MP0004782_abnormal_surfactant_physiolog1.59804480
43MP0001346_abnormal_lacrimal_gland1.56240228
44MP0005464_abnormal_platelet_physiology1.52753461
45MP0002998_abnormal_bone_remodeling1.45943693
46MP0002009_preneoplasia1.41561477
47MP0004381_abnormal_hair_follicle1.39915552
48MP0008469_abnormal_protein_level1.35585934
49MP0002429_abnormal_blood_cell1.31698189
50MP0002877_abnormal_melanocyte_morpholog1.28708349
51MP0000689_abnormal_spleen_morphology1.24577997
52MP0002722_abnormal_immune_system1.21503938
53MP0003191_abnormal_cellular_cholesterol1.15863205
54MP0002933_joint_inflammation1.15621900
55MP0001348_abnormal_lacrimal_gland1.15595248
56MP0000343_altered_response_to1.14408155
57MP0003172_abnormal_lysosome_physiology1.05832976
58MP0003075_altered_response_to1.04469795
59MP0003186_abnormal_redox_activity1.03427787
60MP0005390_skeleton_phenotype1.02410590
61MP0005076_abnormal_cell_differentiation1.01241869
62MP0005166_decreased_susceptibility_to1.00893929
63MP0003828_pulmonary_edema0.99987235
64MP0005397_hematopoietic_system_phenotyp0.99855893
65MP0001545_abnormal_hematopoietic_system0.99855893
66MP0005075_abnormal_melanosome_morpholog0.99401065
67MP0005379_endocrine/exocrine_gland_phen0.99252954
68MP0003183_abnormal_peptide_metabolism0.99229018
69MP0005167_abnormal_blood-brain_barrier0.93319191
70MP0009763_increased_sensitivity_to0.86169267
71MP0003453_abnormal_keratinocyte_physiol0.86168440
72MP0003045_fibrosis0.85698267
73MP0000703_abnormal_thymus_morphology0.85576374
74MP0009840_abnormal_foam_cell0.85218172
75MP0000604_amyloidosis0.83793696
76MP0008961_abnormal_basal_metabolism0.83323955
77MP0001663_abnormal_digestive_system0.82849475
78MP0005164_abnormal_response_to0.82031661
79MP0009278_abnormal_bone_marrow0.79969278
80MP0001851_eye_inflammation0.77412057
81MP0001873_stomach_inflammation0.76661054
82MP0002132_abnormal_respiratory_system0.75831998
83MP0000249_abnormal_blood_vessel0.75546848
84MP0003866_abnormal_defecation0.74896725
85MP0001879_abnormal_lymphatic_vessel0.74384322
86MP0005058_abnormal_lysosome_morphology0.73759677
87MP0008004_abnormal_stomach_pH0.73217926
88MP0003690_abnormal_glial_cell0.70847634
89MP0003091_abnormal_cell_migration0.69273339
90MP0000767_abnormal_smooth_muscle0.69148213
91MP0003656_abnormal_erythrocyte_physiolo0.68948323
92MP0003795_abnormal_bone_structure0.68375130
93MP0005451_abnormal_body_composition0.67574096
94MP0000627_abnormal_mammary_gland0.64790271
95MP0003941_abnormal_skin_development0.64665894
96MP0010386_abnormal_urinary_bladder0.63885269
97MP0004808_abnormal_hematopoietic_stem0.63060596
98MP0004130_abnormal_muscle_cell0.62904978
99MP0002136_abnormal_kidney_physiology0.62681286
100MP0008057_abnormal_DNA_replication0.62638134
101MP0002693_abnormal_pancreas_physiology0.62495553
102MP0000371_diluted_coat_color0.62091272
103MP0001986_abnormal_taste_sensitivity0.60930198
104MP0001881_abnormal_mammary_gland0.60826817
105MP0001919_abnormal_reproductive_system0.60744959
106MP0002876_abnormal_thyroid_physiology0.59748038
107MP0001501_abnormal_sleep_pattern0.59240758
108MP0003300_gastrointestinal_ulcer0.58278397
109MP0004883_abnormal_blood_vessel0.57950877
110MP0000490_abnormal_crypts_of0.56959121
111MP0003566_abnormal_cell_adhesion0.56755746
112MP0000372_irregular_coat_pigmentation0.55760346
113MP0002928_abnormal_bile_duct0.54748911
114MP0002396_abnormal_hematopoietic_system0.53371761
115MP0000569_abnormal_digit_pigmentation0.53368815
116MP0010307_abnormal_tumor_latency0.53304040
117MP0003252_abnormal_bile_duct0.53048878
118MP0001191_abnormal_skin_condition0.52989967
119MP0008874_decreased_physiological_sensi0.51648716
120MP0005535_abnormal_body_temperature0.50942697
121MP0009765_abnormal_xenobiotic_induced0.48874289
122MP0001216_abnormal_epidermal_layer0.47738395
123MP0008260_abnormal_autophagy0.47400765

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.47909598
2Recurrent abscess formation (HP:0002722)6.11907078
3Recurrent bacterial skin infections (HP:0005406)5.58748831
4Increased IgM level (HP:0003496)5.22880703
5Mediastinal lymphadenopathy (HP:0100721)5.15861422
6Retrobulbar optic neuritis (HP:0100654)4.96908490
7Optic neuritis (HP:0100653)4.96908490
8Recurrent gram-negative bacterial infections (HP:0005420)4.86996589
9Autoimmune thrombocytopenia (HP:0001973)4.68865184
10Orchitis (HP:0100796)4.59997352
11Myositis (HP:0100614)4.56536562
12Elevated erythrocyte sedimentation rate (HP:0003565)4.39041385
13Abnormality of macrophages (HP:0004311)4.17001822
14Abnormality of T cell number (HP:0011839)3.97283971
15Recurrent fungal infections (HP:0002841)3.96256918
16Vasculitis (HP:0002633)3.86082087
17Gastrointestinal infarctions (HP:0005244)3.58149053
18Recurrent skin infections (HP:0001581)3.57426759
19Chronic obstructive pulmonary disease (HP:0006510)3.50570401
20Obstructive lung disease (HP:0006536)3.50570401
21Gastrointestinal stroma tumor (HP:0100723)3.49966922
22Gingivitis (HP:0000230)3.47987844
23Stomatitis (HP:0010280)3.46502663
24T lymphocytopenia (HP:0005403)3.42128811
25Pulmonary infiltrates (HP:0002113)3.41744657
26Panhypogammaglobulinemia (HP:0003139)3.40632767
27Increased IgE level (HP:0003212)3.30997751
28Recurrent viral infections (HP:0004429)3.23267128
29Prostate neoplasm (HP:0100787)3.19662909
30Basal ganglia calcification (HP:0002135)3.11520200
31Keratoconjunctivitis sicca (HP:0001097)3.11058147
32Arterial thrombosis (HP:0004420)3.02055718
33Chronic mucocutaneous candidiasis (HP:0002728)3.01958445
34Recurrent cutaneous fungal infections (HP:0011370)3.01958445
35Meningitis (HP:0001287)2.99866480
36Hypergammaglobulinemia (HP:0010702)2.88092189
37Keratoconjunctivitis (HP:0001096)2.87293705
38Verrucae (HP:0200043)2.86037200
39Papilloma (HP:0012740)2.86037200
40Leukocytosis (HP:0001974)2.85760586
41Inflammation of the large intestine (HP:0002037)2.85333205
42Hemoptysis (HP:0002105)2.84945190
43Recurrent pneumonia (HP:0006532)2.84874862
44Recurrent sinusitis (HP:0011108)2.83699695
45Abnormality of B cell number (HP:0010975)2.80037044
46IgM deficiency (HP:0002850)2.78272999
47Thyroiditis (HP:0100646)2.73842275
48Periodontitis (HP:0000704)2.70934129
49Pustule (HP:0200039)2.68596051
50Thick nail (HP:0001805)2.67145273
51Cellulitis (HP:0100658)2.67035949
52Gastrointestinal inflammation (HP:0004386)2.66805807
53Autoimmune hemolytic anemia (HP:0001890)2.64315251
54Chest pain (HP:0100749)2.63868276
55Abnormality of eosinophils (HP:0001879)2.58868703
56B lymphocytopenia (HP:0010976)2.58175366
57Eosinophilia (HP:0001880)2.57931352
58Abnormality of T cells (HP:0002843)2.57196590
59Vacuolated lymphocytes (HP:0001922)2.56994731
60Systemic lupus erythematosus (HP:0002725)2.54869317
61Severe combined immunodeficiency (HP:0004430)2.54735021
62Joint swelling (HP:0001386)2.51169043
63Abnormal delayed hypersensitivity skin test (HP:0002963)2.46565989
64Pulmonary embolism (HP:0002204)2.44878518
65Combined immunodeficiency (HP:0005387)2.43901304
66Restrictive lung disease (HP:0002091)2.43312642
67IgG deficiency (HP:0004315)2.42575244
68Interstitial pulmonary disease (HP:0006530)2.39531496
69Abnormality of the prostate (HP:0008775)2.39022157
70Recurrent lower respiratory tract infections (HP:0002783)2.36929396
71IgA deficiency (HP:0002720)2.34461579
72Hematochezia (HP:0002573)2.33519649
73Emphysema (HP:0002097)2.32464506
74Osteomyelitis (HP:0002754)2.27523105
75Myocardial infarction (HP:0001658)2.26721962
76Bronchitis (HP:0012387)2.26505023
77Abnormality of the pericardium (HP:0001697)2.23633654
78Chronic otitis media (HP:0000389)2.20985617
79Arthralgia (HP:0002829)2.20741791
80Gangrene (HP:0100758)2.20643661
81Neoplasm of the tracheobronchial system (HP:0100552)2.19828160
82Encephalitis (HP:0002383)2.19535473
83Chronic diarrhea (HP:0002028)2.19417662
84Agammaglobulinemia (HP:0004432)2.18602823
85Axonal loss (HP:0003447)2.18529424
86Recurrent bronchitis (HP:0002837)2.17887583
87Prolonged bleeding time (HP:0003010)2.17590995
88Urticaria (HP:0001025)2.17425785
89Spinal cord lesions (HP:0100561)2.13380017
90Syringomyelia (HP:0003396)2.13380017
91Anorexia (HP:0002039)2.13077838
92Granulocytopenia (HP:0001913)2.11238301
93Gingival bleeding (HP:0000225)2.10260549
94Chronic sinusitis (HP:0011109)2.10117555
95Anhidrosis (HP:0000970)2.08428405
96Epistaxis (HP:0000421)2.08367547
97Episodic fever (HP:0001954)2.07767356
98Sepsis (HP:0100806)2.07670488
99Abnormality of cells of the lymphoid lineage (HP:0012140)2.05962403
100Premature loss of primary teeth (HP:0006323)2.05933281
101Papilledema (HP:0001085)2.04770554
102Abnormality of the pleura (HP:0002103)2.02040229
103Petechiae (HP:0000967)2.01818992
104Tetraparesis (HP:0002273)2.00492545
105Nasal polyposis (HP:0100582)1.99984915
106Hypochromic anemia (HP:0001931)1.99141825
107Vertebral compression fractures (HP:0002953)1.98690690
108Skin rash (HP:0000988)1.98144648
109Lymphoma (HP:0002665)1.97938881
110Glomerulopathy (HP:0100820)1.96874527
111Osteolytic defects of the hand bones (HP:0009699)1.96785523
112Osteolytic defects of the phalanges of the hand (HP:0009771)1.96785523
113Keratitis (HP:0000491)1.96449596
114Polyneuropathy (HP:0001271)1.95240162
115Abnormality of glycolipid metabolism (HP:0010969)1.94453377
116Abnormality of liposaccharide metabolism (HP:0010968)1.94453377
117Abnormality of glycosphingolipid metabolism (HP:0004343)1.94453377
118Spontaneous hematomas (HP:0007420)1.93136148
119Abnormality of T cell physiology (HP:0011840)1.92653590
120Lymphopenia (HP:0001888)1.90952796
121Stomach cancer (HP:0012126)1.90287137
122Poor head control (HP:0002421)1.87665705
123Alveolar cell carcinoma (HP:0006519)1.86747430
124Porencephaly (HP:0002132)1.85964817
125Segmental peripheral demyelination/remyelination (HP:0003481)1.85697692
126Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.82485686
127Skin ulcer (HP:0200042)1.82278113
128Colitis (HP:0002583)1.82222237
129Abnormality of the nasal septum (HP:0000419)1.80974376

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K146.16157806
2TXK3.44456876
3TBK13.23997463
4IRAK43.09001010
5RIPK43.07083618
6IKBKB2.97972460
7JAK32.87276227
8IRAK32.77064810
9IKBKE2.76331676
10MAP4K12.49722276
11CHUK2.45527497
12PBK2.43313193
13TYK22.39167436
14MST42.33965678
15PIM22.33931485
16FES2.11428988
17BLK2.04091109
18JAK12.02504250
19BMPR21.96951784
20PIM11.55837792
21ERBB31.55387358
22NLK1.51310257
23NEK91.49928034
24SIK31.48731207
25SIK21.45481626
26MAP3K131.36999038
27TEC1.32839754
28ITK1.31422871
29CSK1.29691425
30ZAP701.26705935
31SYK1.22282270
32BTK1.19068819
33NUAK11.18563723
34TNK21.13788830
35FGFR31.12498535
36TRPM71.08217414
37ZAK1.07472708
38RPS6KA41.05877693
39EIF2AK21.04770846
40MAP2K21.03703143
41EPHA31.01668369
42PASK1.01636258
43LCK1.01537930
44IRAK11.01005407
45BCR0.99185987
46EPHB10.98981785
47STK40.98840398
48HCK0.96761963
49STK240.92665556
50IRAK20.91463922
51BMX0.91259869
52YES10.90844795
53TAOK10.90632066
54CAMKK20.89644742
55MARK30.87858099
56LYN0.87795495
57TESK20.87486441
58CLK10.85025016
59HIPK20.84695550
60MAP3K30.84569492
61NME20.84488868
62FGR0.84254150
63JAK20.80996296
64MOS0.80137035
65TGFBR20.78757343
66BMPR1B0.78545407
67KIT0.77894301
68FGFR40.76794458
69PRKCQ0.75907487
70ABL20.75340314
71CAMKK10.73879997
72PDK10.72013814
73MAPK120.70665242
74PRKCD0.67069606
75TAOK30.66300459
76STK100.65489192
77MAPK150.64443636
78MARK20.62233587
79DYRK1B0.58754289
80PRKD20.58366396
81ABL10.56485704
82NEK60.55845930
83MAPKAPK20.55510107
84MAPK110.55393963
85STK30.55143532
86ADRBK20.54741675
87MAP3K70.54032894
88GRK70.53282132
89KSR20.51034632
90MAP3K110.48763776
91FYN0.48421539
92FRK0.48057260
93MAP3K100.47440524
94SIK10.47421593
95CDC42BPA0.47043779
96DMPK0.46582580
97ARAF0.46450026
98SGK20.45215713
99TLK10.41994777
100INSRR0.41369152
101MST1R0.40021177
102MAP2K30.39812576
103MAP3K50.39646628
104PRPF4B0.39398721
105MAP3K120.39274375
106TESK10.38888789
107MAPK40.38039182
108CDK40.37715718
109PIK3CG0.37554178
110RPS6KC10.37311351
111RPS6KL10.37311351
112MAP4K20.36578189
113SGK30.36279605
114CSF1R0.35413468
115PDPK10.34397734
116RPS6KA60.33945015
117RPS6KA50.32121235
118TYRO30.31355040
119PTK60.29800711
120PKN10.29630515
121IGF1R0.29246765
122PRKCH0.28982905
123RPS6KA10.28027613
124BRD40.27511426
125MATK0.26663227
126CDK60.26563179
127GRK60.26007733
128RIPK10.25694236
129TAOK20.25522414
130EGFR0.24289331
131PDGFRB0.23272613
132MAPK70.22713598
133MAP3K10.22350264
134INSR0.22329190
135GSK3A0.18676426
136ERN10.18003075
137PRKCE0.17761613
138MAPK30.17385352

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053324.40573032
2Allograft rejection_Homo sapiens_hsa053303.95434650
3Leishmaniasis_Homo sapiens_hsa051402.87962066
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.83021975
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.77155095
6Autoimmune thyroid disease_Homo sapiens_hsa053202.58687271
7Type I diabetes mellitus_Homo sapiens_hsa049402.55878558
8Toll-like receptor signaling pathway_Homo sapiens_hsa046202.47331811
9NOD-like receptor signaling pathway_Homo sapiens_hsa046212.46483506
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.43540969
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.39050199
12Legionellosis_Homo sapiens_hsa051342.32707140
13Measles_Homo sapiens_hsa051622.26515779
14Rheumatoid arthritis_Homo sapiens_hsa053232.12546036
15Osteoclast differentiation_Homo sapiens_hsa043802.08432553
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.02526800
17Asthma_Homo sapiens_hsa053101.94842099
18Primary immunodeficiency_Homo sapiens_hsa053401.94512270
19Malaria_Homo sapiens_hsa051441.93538934
20TNF signaling pathway_Homo sapiens_hsa046681.91148656
21Staphylococcus aureus infection_Homo sapiens_hsa051501.80344081
22Pertussis_Homo sapiens_hsa051331.77275370
23Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.73399022
24Influenza A_Homo sapiens_hsa051641.72804096
25Tuberculosis_Homo sapiens_hsa051521.70214686
26Viral myocarditis_Homo sapiens_hsa054161.62375320
27Toxoplasmosis_Homo sapiens_hsa051451.58880051
28African trypanosomiasis_Homo sapiens_hsa051431.56412287
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.55601361
30Hematopoietic cell lineage_Homo sapiens_hsa046401.54282149
31Herpes simplex infection_Homo sapiens_hsa051681.51072313
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.50801662
33Antigen processing and presentation_Homo sapiens_hsa046121.45399959
34Salmonella infection_Homo sapiens_hsa051321.45138584
35B cell receptor signaling pathway_Homo sapiens_hsa046621.42622376
36Chemokine signaling pathway_Homo sapiens_hsa040621.40656870
37Apoptosis_Homo sapiens_hsa042101.33830114
38T cell receptor signaling pathway_Homo sapiens_hsa046601.30818265
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.29246660
40Shigellosis_Homo sapiens_hsa051311.19308310
41Phagosome_Homo sapiens_hsa041451.11409268
42Hepatitis B_Homo sapiens_hsa051611.04114521
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.02880929
44Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.93683436
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89967695
46Lysosome_Homo sapiens_hsa041420.87779681
47Hepatitis C_Homo sapiens_hsa051600.87050290
48Leukocyte transendothelial migration_Homo sapiens_hsa046700.86745997
49Non-small cell lung cancer_Homo sapiens_hsa052230.79495000
50Acute myeloid leukemia_Homo sapiens_hsa052210.77544975
51VEGF signaling pathway_Homo sapiens_hsa043700.75519805
52Prolactin signaling pathway_Homo sapiens_hsa049170.74117927
53Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72111429
54Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.67922706
55Epstein-Barr virus infection_Homo sapiens_hsa051690.65183003
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64071434
57Amoebiasis_Homo sapiens_hsa051460.63501895
58SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63114794
59Renal cell carcinoma_Homo sapiens_hsa052110.61396795
60Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60662541
61Other glycan degradation_Homo sapiens_hsa005110.60097839
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57843068
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56390685
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55642156
65Chronic myeloid leukemia_Homo sapiens_hsa052200.54267939
66Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53282613
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51378757
68Prion diseases_Homo sapiens_hsa050200.50557755
69HTLV-I infection_Homo sapiens_hsa051660.49462405
70Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48535475
71Pancreatic cancer_Homo sapiens_hsa052120.48508736
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46767570
73Platelet activation_Homo sapiens_hsa046110.46369027
74Choline metabolism in cancer_Homo sapiens_hsa052310.45489306
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.44362623
76Regulation of autophagy_Homo sapiens_hsa041400.43391605
77Endocytosis_Homo sapiens_hsa041440.43356094
78Small cell lung cancer_Homo sapiens_hsa052220.42294166
79GnRH signaling pathway_Homo sapiens_hsa049120.41430185
80FoxO signaling pathway_Homo sapiens_hsa040680.41370901
81Phospholipase D signaling pathway_Homo sapiens_hsa040720.41023213
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39895216
83Adherens junction_Homo sapiens_hsa045200.38745487
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38150346
85Prostate cancer_Homo sapiens_hsa052150.36561981
86Endometrial cancer_Homo sapiens_hsa052130.36277029
87Viral carcinogenesis_Homo sapiens_hsa052030.35618814
88Inositol phosphate metabolism_Homo sapiens_hsa005620.34597508
89p53 signaling pathway_Homo sapiens_hsa041150.33754005
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.32802573
91mTOR signaling pathway_Homo sapiens_hsa041500.32058689
92Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.31799372
93Circadian rhythm_Homo sapiens_hsa047100.29395903
94Ras signaling pathway_Homo sapiens_hsa040140.29356238
95alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28367653
96ErbB signaling pathway_Homo sapiens_hsa040120.28342549
97Proteoglycans in cancer_Homo sapiens_hsa052050.27693316
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.26929629
99HIF-1 signaling pathway_Homo sapiens_hsa040660.26410341
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.25644552
101Glycosaminoglycan degradation_Homo sapiens_hsa005310.25389978
102Collecting duct acid secretion_Homo sapiens_hsa049660.25229568
103Notch signaling pathway_Homo sapiens_hsa043300.23420395
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.23180775
105MAPK signaling pathway_Homo sapiens_hsa040100.21801764
106Systemic lupus erythematosus_Homo sapiens_hsa053220.21068095
107MicroRNAs in cancer_Homo sapiens_hsa052060.20723810
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.20413910
109Mineral absorption_Homo sapiens_hsa049780.19640650
110Dorso-ventral axis formation_Homo sapiens_hsa043200.17427485
111Arachidonic acid metabolism_Homo sapiens_hsa005900.15939715
112Type II diabetes mellitus_Homo sapiens_hsa049300.13621166
113Pathways in cancer_Homo sapiens_hsa052000.12596714
114Complement and coagulation cascades_Homo sapiens_hsa046100.11681694
115TGF-beta signaling pathway_Homo sapiens_hsa043500.11584283
116Sphingolipid metabolism_Homo sapiens_hsa006000.10748164
117Insulin resistance_Homo sapiens_hsa049310.10694548
118Protein export_Homo sapiens_hsa030600.08812740
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.08804230
120Focal adhesion_Homo sapiens_hsa045100.08521418
121Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.06456897
122Colorectal cancer_Homo sapiens_hsa052100.06256456

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