BTG1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)8.35077096
2negative regulation of cell killing (GO:0031342)8.08681896
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)8.08681896
4negative T cell selection (GO:0043383)7.20670852
5positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.86139671
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.84029834
7negative thymic T cell selection (GO:0045060)6.70275290
8regulation of B cell receptor signaling pathway (GO:0050855)6.36269746
9regulation of gamma-delta T cell activation (GO:0046643)6.10730836
10positive T cell selection (GO:0043368)6.02601579
11regulation of gamma-delta T cell differentiation (GO:0045586)6.00628964
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.77857532
13activated T cell proliferation (GO:0050798)5.52888857
14positive thymic T cell selection (GO:0045059)5.44975852
15antigen processing and presentation of endogenous antigen (GO:0019883)5.28069655
16antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.24241801
17T cell selection (GO:0045058)5.21785918
18thymic T cell selection (GO:0045061)5.17847514
19tolerance induction (GO:0002507)5.16515893
20cellular response to interleukin-15 (GO:0071350)5.13847191
21leukocyte aggregation (GO:0070486)5.13620307
22response to interleukin-15 (GO:0070672)5.06794739
23negative regulation of T cell mediated immunity (GO:0002710)4.99418498
24negative regulation of lymphocyte mediated immunity (GO:0002707)4.60749617
25regulation of T cell tolerance induction (GO:0002664)4.57476504
26regulation of natural killer cell mediated immunity (GO:0002715)4.50965001
27regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.50965001
28interferon-gamma production (GO:0032609)4.44658965
29regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.44386131
30T cell migration (GO:0072678)4.41869506
31regulation of alpha-beta T cell proliferation (GO:0046640)4.40506018
32positive regulation of tolerance induction (GO:0002645)4.25020452
33positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.21935172
34positive regulation of granulocyte differentiation (GO:0030854)4.20568197
35modulation by symbiont of host immune response (GO:0052553)4.16998445
36positive regulation by symbiont of host defense response (GO:0052509)4.16998445
37modulation by symbiont of host defense response (GO:0052031)4.16998445
38modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.16998445
39modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.16998445
40positive regulation by organism of defense response of other organism involved in symbiotic interact4.16998445
41T cell receptor signaling pathway (GO:0050852)4.11565607
42regulation of tolerance induction (GO:0002643)4.08898487
43regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.03356891
44positive regulation of natural killer cell mediated immunity (GO:0002717)4.02060235
45signal complex assembly (GO:0007172)3.94630891
46positive regulation of alpha-beta T cell proliferation (GO:0046641)3.90195284
47detection of other organism (GO:0098543)3.89820387
48antigen processing and presentation via MHC class Ib (GO:0002475)3.88979028
49B cell receptor signaling pathway (GO:0050853)3.88104639
50detection of bacterium (GO:0016045)3.84572886
51negative regulation of leukocyte mediated immunity (GO:0002704)3.83649722
52antigen receptor-mediated signaling pathway (GO:0050851)3.79021279
53regulation of leukocyte mediated cytotoxicity (GO:0001910)3.73135399
54regulation of B cell differentiation (GO:0045577)3.72500057
55positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.64675282
56positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.63334419
57regulation of T cell mediated cytotoxicity (GO:0001914)3.61350390
58regulation of T cell receptor signaling pathway (GO:0050856)3.58499351
59positive regulation of humoral immune response (GO:0002922)3.55591081
60negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.55270531
61positive regulation of T cell mediated cytotoxicity (GO:0001916)3.38023183
62regulation of regulatory T cell differentiation (GO:0045589)3.37166414
63regulation of cell killing (GO:0031341)3.33629549
64positive regulation of cell killing (GO:0031343)3.28081950
65positive regulation of B cell differentiation (GO:0045579)3.25083411
66cellular extravasation (GO:0045123)3.23101704
67negative regulation of interleukin-12 production (GO:0032695)3.22658207
68histone H3-K36 demethylation (GO:0070544)3.22573508
69positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.22097032
70regulation of isotype switching to IgG isotypes (GO:0048302)3.21214985
71alpha-beta T cell activation (GO:0046631)3.18812928
72alpha-beta T cell differentiation (GO:0046632)3.18640244
73microglial cell activation (GO:0001774)3.18553287
74mast cell activation (GO:0045576)3.17123237
75negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.15933074
76T cell differentiation (GO:0030217)3.14067157
77macrophage activation involved in immune response (GO:0002281)3.10830558
78regulation of granulocyte differentiation (GO:0030852)3.07666665
79positive regulation of natural killer cell differentiation (GO:0032825)3.06310063
80detection of external biotic stimulus (GO:0098581)3.03824214
81respiratory burst (GO:0045730)3.02750299
82negative regulation of T cell receptor signaling pathway (GO:0050860)3.00591002
83detection of molecule of bacterial origin (GO:0032490)2.93460680
84T cell proliferation (GO:0042098)2.88851407
85positive regulation of immunoglobulin mediated immune response (GO:0002891)2.88268438
86positive regulation of B cell mediated immunity (GO:0002714)2.88268438
87positive regulation of isotype switching (GO:0045830)2.86538671
88T cell activation (GO:0042110)2.85489198
89regulation of T cell mediated immunity (GO:0002709)2.85227274
90lymphocyte migration (GO:0072676)2.85100924
91negative regulation of glycoprotein biosynthetic process (GO:0010561)2.84619866
92regulation of interleukin-2 biosynthetic process (GO:0045076)2.84516047
93T cell costimulation (GO:0031295)2.83829804
94negative regulation of phagocytosis (GO:0050765)2.83825217
95T cell homeostasis (GO:0043029)2.83602341
96dendritic cell chemotaxis (GO:0002407)2.83479053
97response to type I interferon (GO:0034340)2.83015823
98negative regulation of adaptive immune response (GO:0002820)2.82690990
99cellular response to type I interferon (GO:0071357)2.82385648
100type I interferon signaling pathway (GO:0060337)2.82385648

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.00413184
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.92844380
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.03443791
4RUNX_20019798_ChIP-Seq_JUKART_Human4.44771478
5MYB_26560356_Chip-Seq_TH2_Human3.74422349
6STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.66165540
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.58299772
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.44234628
9FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.41149487
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.07864257
11BP1_19119308_ChIP-ChIP_Hs578T_Human3.04225464
12MYB_26560356_Chip-Seq_TH1_Human2.97967014
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.93301403
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.72745331
15GATA3_27048872_Chip-Seq_THYMUS_Human2.71533343
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.65985310
17UTX_26944678_Chip-Seq_JUKART_Human2.65019384
18MAF_26560356_Chip-Seq_TH1_Human2.59694794
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.53561246
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.50503877
21IRF8_27001747_Chip-Seq_BMDM_Mouse2.42799357
22SPI1_23547873_ChIP-Seq_NB4_Human2.31571003
23SCL_19346495_ChIP-Seq_HPC-7_Human2.30950384
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.20407277
25MAF_26560356_Chip-Seq_TH2_Human2.15472617
26E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.09810266
27MYB_21317192_ChIP-Seq_ERMYB_Mouse2.09609371
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.04558925
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.02389917
30GATA3_26560356_Chip-Seq_TH2_Human2.00267881
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.99244842
32MYC_22102868_ChIP-Seq_BL_Human1.91373365
33VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.91106237
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.86867773
35RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.82323414
36SPI1_23127762_ChIP-Seq_K562_Human1.79156994
37BRD4_27068464_Chip-Seq_AML-cells_Mouse1.75313719
38KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.72365086
39NOTCH1_21737748_ChIP-Seq_TLL_Human1.68934296
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.67767124
41VDR_24763502_ChIP-Seq_THP-1_Human1.66634464
42VDR_21846776_ChIP-Seq_THP-1_Human1.58730370
43STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.58090429
44MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.55554789
45KDM2B_26808549_Chip-Seq_DND41_Human1.46086417
46TCF7_22412390_ChIP-Seq_EML_Mouse1.45312490
47CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.44392020
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.38700503
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.35577717
50KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.28073852
51NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.25169636
52VDR_24787735_ChIP-Seq_THP-1_Human1.25108976
53VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.23491165
54KDM2B_26808549_Chip-Seq_SUP-B15_Human1.20563703
55EGR1_19374776_ChIP-ChIP_THP-1_Human1.19348296
56CIITA_25753668_ChIP-Seq_RAJI_Human1.17687294
57KDM2B_26808549_Chip-Seq_JURKAT_Human1.17373913
58LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.17274472
59FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.16942322
60PU_27001747_Chip-Seq_BMDM_Mouse1.14130625
61TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.14021484
62CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12368085
63PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11329760
64GATA2_22383799_ChIP-Seq_G1ME_Mouse1.07033215
65LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04870406
66PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02115134
67Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.01714031
68PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01418735
69GATA3_26560356_Chip-Seq_TH1_Human0.99233413
70GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99138313
71BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.97840675
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.97036361
73RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.96717718
74GATA1_19941827_ChIP-Seq_MEL_Mouse0.96195831
75CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.94164185
76CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93856782
77TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90821327
78CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89901246
79GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88048610
80SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84958304
81RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.84856911
82SMRT_27268052_Chip-Seq_Bcells_Human0.81855800
83RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81624330
84FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81553722
85PU.1_20513432_ChIP-Seq_Bcells_Mouse0.80772110
86FOXP3_21729870_ChIP-Seq_TREG_Human0.80338200
87PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80274605
88SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.76328676
89VDR_23849224_ChIP-Seq_CD4+_Human0.74888528
90CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.72114531
91TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.71140655
92GATA2_19941826_ChIP-Seq_K562_Human0.69310202
93GATA1_19941826_ChIP-Seq_K562_Human0.67748179
94TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.67681364
95GATA1_19941827_ChIP-Seq_MEL86_Mouse0.66904808
96BCL6_27268052_Chip-Seq_Bcells_Human0.66538870
97GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.64879193
98GATA1_22383799_ChIP-Seq_G1ME_Mouse0.64465261
99PRDM14_20953172_ChIP-Seq_ESCs_Human0.61367352
100GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.61351637

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology5.14903763
2MP0005671_abnormal_response_to4.06324685
3MP0003724_increased_susceptibility_to3.55036090
4MP0001800_abnormal_humoral_immune3.49874272
5MP0001835_abnormal_antigen_presentation3.49446066
6MP0003436_decreased_susceptibility_to3.44121305
7MP0005000_abnormal_immune_tolerance2.97146230
8MP0002420_abnormal_adaptive_immunity2.92437229
9MP0000685_abnormal_immune_system2.90351955
10MP0001819_abnormal_immune_cell2.89751270
11MP0002723_abnormal_immune_serum2.83059415
12MP0005075_abnormal_melanosome_morpholog2.77857750
13MP0000703_abnormal_thymus_morphology2.74781893
14MP0001790_abnormal_immune_system2.68737909
15MP0005387_immune_system_phenotype2.68737909
16MP0005025_abnormal_response_to2.65254898
17MP0002398_abnormal_bone_marrow2.62726824
18MP0002452_abnormal_antigen_presenting2.59811704
19MP0008260_abnormal_autophagy2.53889404
20MP0002419_abnormal_innate_immunity2.52829893
21MP0009785_altered_susceptibility_to2.42236003
22MP0004381_abnormal_hair_follicle2.40816820
23MP0000716_abnormal_immune_system2.33034881
24MP0002405_respiratory_system_inflammati2.30436878
25MP0002722_abnormal_immune_system2.22782145
26MP0003300_gastrointestinal_ulcer2.22687310
27MP0000689_abnormal_spleen_morphology2.21455587
28MP0006082_CNS_inflammation2.17850858
29MP0009333_abnormal_splenocyte_physiolog2.17120690
30MP0005451_abnormal_body_composition1.94235582
31MP0003866_abnormal_defecation1.93486557
32MP0004947_skin_inflammation1.89983926
33MP0002132_abnormal_respiratory_system1.86064791
34MP0010155_abnormal_intestine_physiology1.84753942
35MP0005464_abnormal_platelet_physiology1.81506647
36MP0002429_abnormal_blood_cell1.79216609
37MP0003303_peritoneal_inflammation1.78694472
38MP0001851_eye_inflammation1.74981402
39MP0001845_abnormal_inflammatory_respons1.67382977
40MP0008961_abnormal_basal_metabolism1.55939487
41MP0002148_abnormal_hypersensitivity_rea1.53546727
42MP0000569_abnormal_digit_pigmentation1.48805869
43MP0002009_preneoplasia1.41882826
44MP0000465_gastrointestinal_hemorrhage1.41296832
45MP0002396_abnormal_hematopoietic_system1.40892535
46MP0004883_abnormal_blood_vessel1.38099209
47MP0002166_altered_tumor_susceptibility1.37335200
48MP0001533_abnormal_skeleton_physiology1.35612248
49MP0002933_joint_inflammation1.29208983
50MP0008469_abnormal_protein_level1.22513728
51MP0009764_decreased_sensitivity_to1.15874012
52MP0001873_stomach_inflammation1.15731226
53MP0000858_altered_metastatic_potential1.11668721
54MP0002822_catalepsy1.09350301
55MP0005310_abnormal_salivary_gland1.06057047
56MP0003172_abnormal_lysosome_physiology1.04366347
57MP0004130_abnormal_muscle_cell0.99063399
58MP0009765_abnormal_xenobiotic_induced0.98131704
59MP0009763_increased_sensitivity_to0.96881761
60MP0008877_abnormal_DNA_methylation0.95558639
61MP0002277_abnormal_respiratory_mucosa0.95308619
62MP0008995_early_reproductive_senescence0.91355527
63MP0003690_abnormal_glial_cell0.90605657
64MP0003828_pulmonary_edema0.83555052
65MP0003656_abnormal_erythrocyte_physiolo0.83423612
66MP0002998_abnormal_bone_remodeling0.82569953
67MP0002019_abnormal_tumor_incidence0.82480351
68MP0002006_tumorigenesis0.74735614
69MP0001853_heart_inflammation0.74733585
70MP0001986_abnormal_taste_sensitivity0.71467978
71MP0001663_abnormal_digestive_system0.69330991
72MP0005164_abnormal_response_to0.67490946
73MP0005408_hypopigmentation0.64868342
74MP0003787_abnormal_imprinting0.64631990
75MP0005174_abnormal_tail_pigmentation0.63497295
76MP0000372_irregular_coat_pigmentation0.62656580
77MP0000015_abnormal_ear_pigmentation0.61797486
78MP0009278_abnormal_bone_marrow0.61630975
79MP0000490_abnormal_crypts_of0.59027842
80MP0004484_altered_response_of0.58100338
81MP0001919_abnormal_reproductive_system0.57426275
82MP0003448_altered_tumor_morphology0.56103950
83MP0005388_respiratory_system_phenotype0.54475196
84MP0002133_abnormal_respiratory_system0.54475196
85MP0005397_hematopoietic_system_phenotyp0.54305644
86MP0001545_abnormal_hematopoietic_system0.54305644
87MP0003252_abnormal_bile_duct0.53773850
88MP0000249_abnormal_blood_vessel0.52047095
89MP0002693_abnormal_pancreas_physiology0.51926133
90MP0003191_abnormal_cellular_cholesterol0.50555700
91MP0003638_abnormal_response/metabolism_0.49341960
92MP0003878_abnormal_ear_physiology0.47606752
93MP0005377_hearing/vestibular/ear_phenot0.47606752
94MP0008873_increased_physiological_sensi0.46979583
95MP0005166_decreased_susceptibility_to0.46484143
96MP0004808_abnormal_hematopoietic_stem0.46473046
97MP0008057_abnormal_DNA_replication0.45609251
98MP0000371_diluted_coat_color0.43029714
99MP0010329_abnormal_lipoprotein_level0.42955267
100MP0003795_abnormal_bone_structure0.39854928

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)6.02221371
2Abnormality of T cell number (HP:0011839)5.44395491
3Eczematoid dermatitis (HP:0000976)5.42500097
4Increased IgM level (HP:0003496)5.17006111
5IgG deficiency (HP:0004315)5.15021037
6IgM deficiency (HP:0002850)4.90337437
7Myositis (HP:0100614)4.89717304
8Retrobulbar optic neuritis (HP:0100654)4.79724893
9Optic neuritis (HP:0100653)4.79724893
10Encephalitis (HP:0002383)4.72373981
11Pustule (HP:0200039)4.64810460
12Recurrent abscess formation (HP:0002722)4.50032631
13Abnormality of T cells (HP:0002843)4.48465601
14Severe combined immunodeficiency (HP:0004430)4.47685649
15Orchitis (HP:0100796)4.45519442
16Recurrent bacterial skin infections (HP:0005406)4.38589931
17Gastrointestinal infarctions (HP:0005244)4.20510937
18Abnormality of macrophages (HP:0004311)3.99667859
19Stomatitis (HP:0010280)3.97338046
20Granulocytopenia (HP:0001913)3.94415446
21Eosinophilia (HP:0001880)3.84513506
22Elevated erythrocyte sedimentation rate (HP:0003565)3.81590136
23Abnormality of eosinophils (HP:0001879)3.77066462
24Recurrent fungal infections (HP:0002841)3.72812660
25Meningitis (HP:0001287)3.70841497
26Combined immunodeficiency (HP:0005387)3.67919330
27Mediastinal lymphadenopathy (HP:0100721)3.62887582
28Recurrent bronchitis (HP:0002837)3.61914433
29Leukocytosis (HP:0001974)3.60276752
30Keratoconjunctivitis sicca (HP:0001097)3.54412550
31Recurrent gram-negative bacterial infections (HP:0005420)3.53314499
32Abnormal delayed hypersensitivity skin test (HP:0002963)3.53283944
33Keratoconjunctivitis (HP:0001096)3.37421822
34Acute hepatic failure (HP:0006554)3.33219314
35Abnormality of T cell physiology (HP:0011840)3.32334467
36Lymphopenia (HP:0001888)3.30136815
37Panhypogammaglobulinemia (HP:0003139)3.22076950
38Vasculitis (HP:0002633)3.21859074
39Autoimmune hemolytic anemia (HP:0001890)3.21302081
40Spontaneous hematomas (HP:0007420)3.18213627
41IgA deficiency (HP:0002720)3.11420238
42Gingivitis (HP:0000230)3.08279186
43Inflammation of the large intestine (HP:0002037)2.99769148
44Prolonged bleeding time (HP:0003010)2.99102587
45Recurrent cutaneous fungal infections (HP:0011370)2.98059750
46Chronic mucocutaneous candidiasis (HP:0002728)2.98059750
47Abnormality of cells of the lymphoid lineage (HP:0012140)2.96185786
48Papilloma (HP:0012740)2.95959122
49Verrucae (HP:0200043)2.95959122
50Abnormality of B cell number (HP:0010975)2.95858778
51Recurrent skin infections (HP:0001581)2.94078535
52Gastrointestinal inflammation (HP:0004386)2.90035600
53B lymphocytopenia (HP:0010976)2.82403147
54Chronic obstructive pulmonary disease (HP:0006510)2.70483453
55Obstructive lung disease (HP:0006536)2.70483453
56Anorexia (HP:0002039)2.68199776
57Hemoptysis (HP:0002105)2.67497735
58Pulmonary infiltrates (HP:0002113)2.67017072
59Chest pain (HP:0100749)2.66732231
60Thyroiditis (HP:0100646)2.65864874
61Abnormality of the fingertips (HP:0001211)2.64604249
62Recurrent viral infections (HP:0004429)2.58482699
63Pulmonary embolism (HP:0002204)2.58370756
64Increased IgE level (HP:0003212)2.58207900
65Hypergammaglobulinemia (HP:0010702)2.56790422
66Gangrene (HP:0100758)2.56612507
67Hyperlipoproteinemia (HP:0010980)2.53696469
68Oligodactyly (hands) (HP:0001180)2.51289320
69Colitis (HP:0002583)2.50162397
70Joint swelling (HP:0001386)2.50060627
71Hypoplasia of the thymus (HP:0000778)2.46654206
72Arterial thrombosis (HP:0004420)2.43644923
73Epistaxis (HP:0000421)2.36165906
74Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.35458214
75Gingival bleeding (HP:0000225)2.35309626
76Lymphoma (HP:0002665)2.33713366
77Hematochezia (HP:0002573)2.28284613
78Keratitis (HP:0000491)2.23829518
79Hypochromic microcytic anemia (HP:0004840)2.22390854
80Chronic diarrhea (HP:0002028)2.21376503
81Loss of speech (HP:0002371)2.17315583
82Agammaglobulinemia (HP:0004432)2.15574807
83Bronchitis (HP:0012387)2.06751520
84Hypochromic anemia (HP:0001931)1.99565694
85Hemiplegia (HP:0002301)1.97620522
86Cellular immunodeficiency (HP:0005374)1.94720484
87Papilledema (HP:0001085)1.94458317
88Recurrent sinusitis (HP:0011108)1.94078654
89Supernumerary ribs (HP:0005815)1.91047173
90Abnormality of the pleura (HP:0002103)1.90115961
91Thick nail (HP:0001805)1.86633174
92Vertigo (HP:0002321)1.82518991
93Teleangiectasia of the skin (HP:0100585)1.80053643
94Hypoplastic nipples (HP:0002557)1.78828360
95Abnormality of pyrimidine metabolism (HP:0004353)1.77584263
96Sepsis (HP:0100806)1.76541962
97Glomerulopathy (HP:0100820)1.75783146
98Supernumerary bones of the axial skeleton (HP:0009144)1.73854446
99Cellulitis (HP:0100658)1.72580029
100Urticaria (HP:0001025)1.72117100

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.73388179
2TXK4.27947128
3GRK63.46998504
4RIPK42.79474857
5CSK2.73649542
6MAP3K132.65233025
7FES2.39063554
8TYK22.27207256
9ITK2.23365333
10MARK32.09278971
11BTK2.09166554
12PRPF4B2.07838020
13TAOK32.05931972
14EPHB12.04065453
15SYK1.99578984
16NLK1.96585684
17ZAP701.94596709
18CAMKK21.87530746
19NEK61.78717942
20BLK1.78138443
21IKBKE1.76783852
22PASK1.69307324
23JAK11.67093687
24TEC1.63104872
25JAK31.63032552
26HCK1.62974247
27SIK31.61250267
28LCK1.55007882
29MAP3K141.44843943
30TNK21.44534169
31CAMKK11.40915615
32TAOK11.35818735
33MAP2K31.33130418
34LYN1.29143720
35FGFR41.23503565
36CDK41.22904120
37IRAK41.22699590
38FGR1.18808124
39CDK61.17789900
40FGFR31.17630857
41MELK1.10041186
42MAP3K71.09641811
43PRKCQ1.03041417
44PIM11.03036305
45STK101.02677515
46MAP3K101.02138102
47PTK2B0.96720302
48JAK20.90622878
49SIK20.90369125
50CLK10.82043786
51KDR0.81620756
52KSR20.81324754
53TBK10.78810269
54TYRO30.78247738
55IKBKB0.75381389
56BMPR20.75118433
57MARK20.74852156
58PDK10.73704385
59MAP3K30.72513186
60SGK20.72387982
61MAP3K10.72378813
62YES10.71492669
63FGFR20.70743710
64FYN0.68976880
65RAF10.67810300
66STK110.67572559
67ERN10.67146325
68PIK3CG0.67065598
69UHMK10.65716592
70SGK30.62166956
71MAPK110.62146935
72STK380.58706730
73ACVR1B0.56937821
74CSF1R0.56883063
75MAP3K20.56383229
76MAPK130.54491335
77MAPK120.54192732
78STK40.52124924
79KIT0.51825699
80TESK20.49783714
81MAPKAPK30.49587509
82TLK10.48427818
83TRPM70.47805332
84CAMK40.46966369
85TGFBR20.44296769
86MAP3K110.43370524
87MAPK70.43255662
88HIPK20.42511501
89PTK60.39470996
90RET0.39054758
91LRRK20.36573423
92PRKCH0.35717416
93IRAK10.34991000
94EGFR0.32610970
95GRK70.32563163
96NUAK10.31757032
97CDC42BPA0.28760484
98DYRK1B0.26861894
99PDPK10.26568132
100SGK2230.26177260

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.19139194
2T cell receptor signaling pathway_Homo sapiens_hsa046603.58984555
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.22412092
4B cell receptor signaling pathway_Homo sapiens_hsa046622.45000892
5Graft-versus-host disease_Homo sapiens_hsa053322.44824859
6Osteoclast differentiation_Homo sapiens_hsa043802.38897963
7Measles_Homo sapiens_hsa051622.35510125
8Allograft rejection_Homo sapiens_hsa053302.09308578
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.08483304
10Autoimmune thyroid disease_Homo sapiens_hsa053202.05306086
11Hematopoietic cell lineage_Homo sapiens_hsa046401.93811423
12Leishmaniasis_Homo sapiens_hsa051401.92693494
13Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.89748637
14Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.87770435
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.84724763
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.83884005
17Acute myeloid leukemia_Homo sapiens_hsa052211.83434422
18Antigen processing and presentation_Homo sapiens_hsa046121.78047067
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.77500358
20Staphylococcus aureus infection_Homo sapiens_hsa051501.75768503
21Chemokine signaling pathway_Homo sapiens_hsa040621.74243480
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.60651312
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.54040033
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.50186372
25Type I diabetes mellitus_Homo sapiens_hsa049401.43538908
26Tuberculosis_Homo sapiens_hsa051521.42126976
27Platelet activation_Homo sapiens_hsa046111.35160822
28Leukocyte transendothelial migration_Homo sapiens_hsa046701.34332666
29Malaria_Homo sapiens_hsa051441.33600035
30Viral myocarditis_Homo sapiens_hsa054161.33239446
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.29790233
32Non-small cell lung cancer_Homo sapiens_hsa052231.28908252
33Herpes simplex infection_Homo sapiens_hsa051681.28206772
34Toxoplasmosis_Homo sapiens_hsa051451.27384550
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.22918460
36Hepatitis B_Homo sapiens_hsa051611.20154287
37FoxO signaling pathway_Homo sapiens_hsa040681.14582834
38VEGF signaling pathway_Homo sapiens_hsa043701.12839208
39Pancreatic cancer_Homo sapiens_hsa052121.10926573
40TNF signaling pathway_Homo sapiens_hsa046681.09588773
41Shigellosis_Homo sapiens_hsa051311.09116900
42Phosphatidylinositol signaling system_Homo sapiens_hsa040700.98942647
43Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.95449716
44HTLV-I infection_Homo sapiens_hsa051660.94522258
45Influenza A_Homo sapiens_hsa051640.91019148
46Colorectal cancer_Homo sapiens_hsa052100.90861430
47Chronic myeloid leukemia_Homo sapiens_hsa052200.90195409
48Apoptosis_Homo sapiens_hsa042100.87575454
49Epstein-Barr virus infection_Homo sapiens_hsa051690.87003702
50Hepatitis C_Homo sapiens_hsa051600.84078968
51Choline metabolism in cancer_Homo sapiens_hsa052310.80288636
52Viral carcinogenesis_Homo sapiens_hsa052030.78630836
53Legionellosis_Homo sapiens_hsa051340.78144339
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71766911
55Linoleic acid metabolism_Homo sapiens_hsa005910.71666877
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67127540
57Endometrial cancer_Homo sapiens_hsa052130.66218286
58Endocytosis_Homo sapiens_hsa041440.65792908
59Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63987645
60Renal cell carcinoma_Homo sapiens_hsa052110.63096512
61Prolactin signaling pathway_Homo sapiens_hsa049170.61990555
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61983497
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.61831179
64Inositol phosphate metabolism_Homo sapiens_hsa005620.61147217
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.60951878
66MAPK signaling pathway_Homo sapiens_hsa040100.58676416
67Pertussis_Homo sapiens_hsa051330.56797575
68Ras signaling pathway_Homo sapiens_hsa040140.56776850
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56000063
70mTOR signaling pathway_Homo sapiens_hsa041500.53780940
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52981010
72Glycerophospholipid metabolism_Homo sapiens_hsa005640.51762448
73Prostate cancer_Homo sapiens_hsa052150.51590714
74Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51294466
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.49784035
76Insulin resistance_Homo sapiens_hsa049310.49546352
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49350172
78GnRH signaling pathway_Homo sapiens_hsa049120.48988566
79Regulation of autophagy_Homo sapiens_hsa041400.48434160
80Other glycan degradation_Homo sapiens_hsa005110.46881304
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44530250
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.44497657
83Phagosome_Homo sapiens_hsa041450.41892186
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41214341
85Dorso-ventral axis formation_Homo sapiens_hsa043200.40736554
86Long-term potentiation_Homo sapiens_hsa047200.39637240
87Asthma_Homo sapiens_hsa053100.39334326
88Rap1 signaling pathway_Homo sapiens_hsa040150.38171770
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37839736
90Circadian rhythm_Homo sapiens_hsa047100.36953160
91Rheumatoid arthritis_Homo sapiens_hsa053230.34183767
92African trypanosomiasis_Homo sapiens_hsa051430.31560803
93Thyroid cancer_Homo sapiens_hsa052160.31071251
94ErbB signaling pathway_Homo sapiens_hsa040120.30950348
95Type II diabetes mellitus_Homo sapiens_hsa049300.30147856
96Oxytocin signaling pathway_Homo sapiens_hsa049210.29505272
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.28313377
98Arachidonic acid metabolism_Homo sapiens_hsa005900.27716319
99HIF-1 signaling pathway_Homo sapiens_hsa040660.27102022
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.26659989

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