BTG2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein is involved in the regulation of the G1/S transition of the cell cycle. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.08047992
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.77877355
3negative regulation of cell killing (GO:0031342)4.77877355
4pharyngeal system development (GO:0060037)4.77576414
5negative regulation of fatty acid transport (GO:2000192)4.74422803
6regulation of cell proliferation involved in kidney development (GO:1901722)4.71166073
7G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.60913596
8interleukin-1-mediated signaling pathway (GO:0070498)4.51858457
9regulation of gamma-delta T cell activation (GO:0046643)4.47567029
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.46966541
11tolerance induction (GO:0002507)4.42034427
12cellular response to follicle-stimulating hormone stimulus (GO:0071372)4.37715044
13modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.14106236
14modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.14106236
15positive regulation by organism of defense response of other organism involved in symbiotic interact4.14106236
16modulation by symbiont of host immune response (GO:0052553)4.14106236
17positive regulation by symbiont of host defense response (GO:0052509)4.14106236
18modulation by symbiont of host defense response (GO:0052031)4.14106236
19regulation of B cell receptor signaling pathway (GO:0050855)4.11072657
20regulation of gamma-delta T cell differentiation (GO:0045586)4.09547694
21regulation of cardioblast proliferation (GO:0003264)4.04124132
22regulation of secondary heart field cardioblast proliferation (GO:0003266)4.04124132
23one-carbon compound transport (GO:0019755)4.03889631
24positive regulation of glomerulus development (GO:0090193)3.98785952
25glucuronate metabolic process (GO:0019585)3.98043017
26uronic acid metabolic process (GO:0006063)3.98043017
27response to nitrosative stress (GO:0051409)3.85158445
28germinal center formation (GO:0002467)3.83167628
29regulation of chemokine secretion (GO:0090196)3.82939137
30macrophage activation involved in immune response (GO:0002281)3.82191779
31cellular extravasation (GO:0045123)3.79512701
32detection of other organism (GO:0098543)3.74588639
33cellular glucuronidation (GO:0052695)3.74318022
34positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.72685684
35cellular response to antibiotic (GO:0071236)3.72422310
36thrombin receptor signaling pathway (GO:0070493)3.71909046
37response to peptidoglycan (GO:0032494)3.70661063
38regulation of interferon-beta biosynthetic process (GO:0045357)3.69011327
39renal absorption (GO:0070293)3.67836852
40cell proliferation involved in kidney development (GO:0072111)3.56982328
41detection of bacterium (GO:0016045)3.55154939
42negative regulation of interleukin-12 production (GO:0032695)3.48296032
43negative regulation of erythrocyte differentiation (GO:0045647)3.46732629
44positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.44256525
45hormone catabolic process (GO:0042447)3.44126862
46xenobiotic catabolic process (GO:0042178)3.44040688
47ear development (GO:0043583)3.43312357
48negative thymic T cell selection (GO:0045060)3.41076046
49positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.40746202
50energy homeostasis (GO:0097009)3.40697656
51desmosome organization (GO:0002934)3.36614751
52positive thymic T cell selection (GO:0045059)3.35847374
53leukocyte aggregation (GO:0070486)3.34674190
54response to progesterone (GO:0032570)3.30914761
55atrioventricular valve morphogenesis (GO:0003181)3.29267266
56NIK/NF-kappaB signaling (GO:0038061)3.24771901
57negative T cell selection (GO:0043383)3.24735109
58cellular response to gonadotropin stimulus (GO:0071371)3.24399004
59regulation of glomerulus development (GO:0090192)3.24040522
60myoblast migration (GO:0051451)3.23470338
61negative regulation of glycogen biosynthetic process (GO:0045719)3.22413684
62endoderm formation (GO:0001706)3.21679260
63B cell receptor signaling pathway (GO:0050853)3.21005415
64interferon-gamma secretion (GO:0072643)3.20802355
65regulation of phospholipase A2 activity (GO:0032429)3.20720662
66metanephric mesenchyme development (GO:0072075)3.20468669
67* skeletal muscle cell differentiation (GO:0035914)3.20044155
68neutrophil activation involved in immune response (GO:0002283)3.17727229
69detection of external biotic stimulus (GO:0098581)3.15538178
70negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.15353617
71cellular response to type I interferon (GO:0071357)3.15317718
72type I interferon signaling pathway (GO:0060337)3.15317718
73response to type I interferon (GO:0034340)3.15002071
74endocardial cushion morphogenesis (GO:0003203)3.14294538
75response to follicle-stimulating hormone (GO:0032354)3.14226736
76immunoglobulin mediated immune response (GO:0016064)3.14048997
77detection of molecule of bacterial origin (GO:0032490)3.14048073
78negative regulation of lymphocyte mediated immunity (GO:0002707)3.13292135
79endothelial cell chemotaxis (GO:0035767)3.12535791
80gland morphogenesis (GO:0022612)3.10517303
81defense response to protozoan (GO:0042832)3.09242103
82T cell migration (GO:0072678)3.08442123
83interferon-gamma-mediated signaling pathway (GO:0060333)3.04610382
84peptide catabolic process (GO:0043171)3.04159412
85response to interleukin-15 (GO:0070672)3.02614103
86negative regulation of T cell mediated immunity (GO:0002710)3.02078206
87cell differentiation involved in metanephros development (GO:0072202)3.00063223
88regulation of interleukin-12 biosynthetic process (GO:0045075)2.96757293
89thymic T cell selection (GO:0045061)2.96299216
90response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.96064511
91response to host immune response (GO:0052572)2.96064511
92response to protozoan (GO:0001562)2.95780752
93regulation of dendritic cell antigen processing and presentation (GO:0002604)2.95234084
94T cell selection (GO:0045058)2.95036238
95regulation of regulatory T cell differentiation (GO:0045589)2.93574175
96positive T cell selection (GO:0043368)2.93199013
97toxin transport (GO:1901998)2.93070121
98glomerulus development (GO:0032835)2.93014622
99nucleotide transmembrane transport (GO:1901679)2.92311624
100purinergic nucleotide receptor signaling pathway (GO:0035590)2.91775903
101detection of biotic stimulus (GO:0009595)2.89900110
102neutrophil activation (GO:0042119)2.89857254
103regulation of protein sumoylation (GO:0033233)2.89109315
104CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.87320784
105antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.85333124
106antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.85333124
107branching involved in labyrinthine layer morphogenesis (GO:0060670)2.83545835
108cellular response to interleukin-15 (GO:0071350)2.83360304
109lipopolysaccharide-mediated signaling pathway (GO:0031663)2.82898338
110radial glial cell differentiation (GO:0060019)2.82507270
111microglial cell activation (GO:0001774)2.81718842
112negative regulation of interleukin-6 production (GO:0032715)2.80961745
113B cell homeostasis (GO:0001782)2.80203026
114neutrophil mediated immunity (GO:0002446)2.79794888
115positive regulation of positive chemotaxis (GO:0050927)2.79594369
116regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.79258804
117regulation of T cell tolerance induction (GO:0002664)2.78323265
118interferon-gamma production (GO:0032609)2.77689261
119response to host (GO:0075136)2.77500872
120response to host defenses (GO:0052200)2.77500872
121response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.77500872
122T-helper 1 type immune response (GO:0042088)2.77489769
123granulocyte activation (GO:0036230)2.75814478
124kidney mesenchyme development (GO:0072074)2.75272336
125positive regulation of B cell differentiation (GO:0045579)2.74148650
126production of molecular mediator involved in inflammatory response (GO:0002532)2.74140714
127negative regulation of leukocyte mediated immunity (GO:0002704)2.74043794
128regulation of alpha-beta T cell proliferation (GO:0046640)2.73209137
129lipoxygenase pathway (GO:0019372)2.72777432
130regulation of tolerance induction (GO:0002643)2.71217784
131mesenchyme morphogenesis (GO:0072132)2.70554975
132regulation of interleukin-2 biosynthetic process (GO:0045076)2.70341035
133regulation of positive chemotaxis (GO:0050926)2.69937279
134positive regulation of receptor recycling (GO:0001921)2.69112048
135regulation of germinal center formation (GO:0002634)2.68079749
136regulation of T-helper 2 cell differentiation (GO:0045628)2.67971418
137positive regulation of cholesterol efflux (GO:0010875)2.67878693
138negative regulation of keratinocyte proliferation (GO:0010839)2.67507783
139regulation of B cell differentiation (GO:0045577)2.66531024
140cellular response to toxic substance (GO:0097237)2.66241314
1413-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.66155119
142purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.66155119
143negative regulation of protein autophosphorylation (GO:0031953)2.66058184
144response to gonadotropin (GO:0034698)2.65816029
145regulation of antigen processing and presentation (GO:0002577)2.65272213
146negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.65075166
147regulation of interleukin-8 secretion (GO:2000482)2.64864697
148positive regulation of interleukin-2 production (GO:0032743)2.64597154
149myeloid dendritic cell differentiation (GO:0043011)2.62869972
150negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.62160923
151regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.61775787
152negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.61315641
153negative regulation of T-helper cell differentiation (GO:0045623)2.61315641
154negative regulation of glycogen metabolic process (GO:0070874)2.60904112
155JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.59504461
156myeloid cell activation involved in immune response (GO:0002275)2.59413970
157positive regulation of cellular amide metabolic process (GO:0034250)2.59140574
158negative regulation of toll-like receptor signaling pathway (GO:0034122)2.58771742
159facial nerve structural organization (GO:0021612)2.56566174
160induction of positive chemotaxis (GO:0050930)2.56269213
161G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.55334773
162negative regulation of innate immune response (GO:0045824)2.55324316
163positive regulation of interferon-alpha production (GO:0032727)2.55144818
164response to increased oxygen levels (GO:0036296)2.53820972
165response to hyperoxia (GO:0055093)2.53820972
166positive regulation of T cell chemotaxis (GO:0010820)2.52441824
167regulation of T cell chemotaxis (GO:0010819)2.52441824
168phenylpropanoid metabolic process (GO:0009698)2.52289446
169antigen processing and presentation of endogenous antigen (GO:0019883)2.51911997
170androgen biosynthetic process (GO:0006702)2.50237013
171viral protein processing (GO:0019082)2.49586830
172T-helper cell differentiation (GO:0042093)2.49438364
173negative regulation of systemic arterial blood pressure (GO:0003085)2.46094296
174regulation of skeletal muscle contraction (GO:0014819)2.45506007
175L-ascorbic acid metabolic process (GO:0019852)2.44705658
176positive regulation of chemokine secretion (GO:0090197)2.44669730
177response to gravity (GO:0009629)2.44583082
178face development (GO:0060324)2.43704772
179response to muramyl dipeptide (GO:0032495)2.43367193
180lung lobe morphogenesis (GO:0060463)2.43052191
181relaxation of cardiac muscle (GO:0055119)2.42355002
182mitotic cell cycle arrest (GO:0071850)2.42146782
183positive regulation of interleukin-8 secretion (GO:2000484)2.41869107
184generation of neurons (GO:0048699)2.41658701
185regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.41615129
186negative regulation of JUN kinase activity (GO:0043508)2.40954365
187negative regulation of osteoblast proliferation (GO:0033689)2.40905144
188ER overload response (GO:0006983)2.39168119
189macrophage activation (GO:0042116)2.38224319
190positive regulation of actin filament depolymerization (GO:0030836)2.37289929
191negative regulation of cAMP-mediated signaling (GO:0043951)2.36607355
192cyclooxygenase pathway (GO:0019371)2.36262695
193positive regulation of kidney development (GO:0090184)2.35830125

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.38779330
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.74190305
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.30411890
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.95197828
5TRIM28_21343339_ChIP-Seq_HEK293_Human3.65057278
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.39024594
7ESR1_21235772_ChIP-Seq_MCF-7_Human3.28541522
8FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.93199127
9KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.84952554
10KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.84952554
11KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.84952554
12* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.82456229
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.80305595
14* SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.76957370
15IRF8_21731497_ChIP-ChIP_J774_Mouse2.71886405
16CLOCK_20551151_ChIP-Seq_293T_Human2.68201563
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.60404408
18IRF8_22096565_ChIP-ChIP_GC-B_Human2.40777712
19ZNF217_24962896_ChIP-Seq_MCF-7_Human2.27647068
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.26661070
21WT1_19549856_ChIP-ChIP_CCG9911_Human2.23583942
22MYC_22102868_ChIP-Seq_BL_Human2.22252069
23* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.20156974
24VDR_24763502_ChIP-Seq_THP-1_Human2.19430435
25VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.19305713
26* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.17919503
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.17048585
28* MAF_26560356_Chip-Seq_TH1_Human2.12995129
29ESR2_21235772_ChIP-Seq_MCF-7_Human2.10837104
30* TCF7_22412390_ChIP-Seq_EML_Mouse2.07768870
31VDR_21846776_ChIP-Seq_THP-1_Human2.05950695
32* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.02869701
33RARG_19884340_ChIP-ChIP_MEFs_Mouse1.98201272
34RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.97837641
35* RUNX_20019798_ChIP-Seq_JUKART_Human1.95016045
36SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.93112437
37* MYB_26560356_Chip-Seq_TH1_Human1.88062810
38UTX_26944678_Chip-Seq_JUKART_Human1.82387335
39SPI1_23127762_ChIP-Seq_K562_Human1.73599271
40* RUNX1_22412390_ChIP-Seq_EML_Mouse1.69837317
41* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.69658756
42* KDM2B_26808549_Chip-Seq_DND41_Human1.66098134
43BRD4_27068464_Chip-Seq_AML-cells_Mouse1.64209159
44STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.63350578
45* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.62219060
46* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.62219060
47* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.61568964
48SPI1_23547873_ChIP-Seq_NB4_Human1.60532716
49RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.60486020
50SCL_19346495_ChIP-Seq_HPC-7_Human1.59118544
51HIF1A_21447827_ChIP-Seq_MCF-7_Human1.58807155
52AHR_22903824_ChIP-Seq_MCF-7_Human1.58708820
53TP53_16413492_ChIP-PET_HCT116_Human1.58590194
54* GATA3_27048872_Chip-Seq_THYMUS_Human1.58449204
55* GATA2_21666600_ChIP-Seq_HMVEC_Human1.57500752
56KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.57304167
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.55194515
58NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.54066977
59STAT6_21828071_ChIP-Seq_BEAS2B_Human1.52515912
60* TP53_18474530_ChIP-ChIP_U2OS_Human1.46102834
61MAF_26560356_Chip-Seq_TH2_Human1.45131816
62SOX9_24532713_ChIP-Seq_HFSC_Mouse1.44684994
63CJUN_26792858_Chip-Seq_BT549_Human1.42603486
64CDX2_20551321_ChIP-Seq_CACO-2_Human1.41754270
65ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.39688956
66MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.38913733
67AR_21572438_ChIP-Seq_LNCaP_Human1.38737685
68* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.36318895
69Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.35133424
70ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.34400491
71FOXO3_23340844_ChIP-Seq_DLD1_Human1.31451955
72NRF2_20460467_ChIP-Seq_MEFs_Mouse1.28816890
73NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.28816890
74IRF1_19129219_ChIP-ChIP_H3396_Human1.28014035
75PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.27115568
76* PU_27001747_Chip-Seq_BMDM_Mouse1.23932342
77KDM2B_26808549_Chip-Seq_JURKAT_Human1.23770193
78CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.23574166
79THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.22193970
80* SOX2_20726797_ChIP-Seq_SW620_Human1.22076745
81ELK3_25401928_ChIP-Seq_HUVEC_Human1.19721529
82NFIB_24661679_ChIP-Seq_LUNG_Mouse1.18959482
83* GATA1_19941827_ChIP-Seq_MEL_Mouse1.18811316
84* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.17843056
85* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.17835419
86* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.16638440
87PPAR_26484153_Chip-Seq_NCI-H1993_Human1.16530568
88* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.14583527
89STAT4_19710469_ChIP-ChIP_TH1__Mouse1.14276473
90* GATA3_26560356_Chip-Seq_TH2_Human1.14250181
91RXR_22108803_ChIP-Seq_LS180_Human1.13436050
92GATA1_22025678_ChIP-Seq_K562_Human1.12259879
93PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11379612
94VDR_24787735_ChIP-Seq_THP-1_Human1.11060564
95ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10966361
96ARNT_22903824_ChIP-Seq_MCF-7_Human1.10215842
97* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.10114838
98GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09372029
99SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07013989
100CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06410895
101TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05565504
102* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.04707694
103* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.04386817
104* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04351863
105FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.02177817
106NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.00738105
107STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.99905057
108ESR1_20079471_ChIP-ChIP_T-47D_Human0.99312060
109PIAS1_25552417_ChIP-Seq_VCAP_Human0.97767655
110NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97195182
111* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96090567
112ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.95994445
113JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91804604
114PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91801657
115SMRT_27268052_Chip-Seq_Bcells_Human0.91586603
116CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91071715
117LXR_22292898_ChIP-Seq_THP-1_Human0.89193483
118* IRF8_27001747_Chip-Seq_BMDM_Mouse0.89141936
119* TP63_23658742_ChIP-Seq_EP156T_Human0.88427836
120IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.88258268
121* RUNX1_27514584_Chip-Seq_MCF-7_Human0.88059832
122* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.87613677
123BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87580075
124PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87056139
125PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86979629
126TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.86510327
127CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84092443
128IKZF1_21737484_ChIP-ChIP_HCT116_Human0.83616939
129RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.83415117
130LXR_22158963_ChIP-Seq_LIVER_Mouse0.82951267
131FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.82735740
132TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82727188
133JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82656577
134GF1B_26923725_Chip-Seq_HPCs_Mouse0.81600694
135SMAD_19615063_ChIP-ChIP_OVARY_Human0.81286108
136CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.80726134
137* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.80715630
138PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.80220330
139MYB_26560356_Chip-Seq_TH2_Human0.79839460
140* ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.79701782
141BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.79646169
142* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.79500841
143GATA1_22383799_ChIP-Seq_G1ME_Mouse0.78907112
144TCF4_18268006_ChIP-ChIP_LS174T_Human0.78856499
145AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.77211292
146SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.77149155
147* UBF1/2_26484160_Chip-Seq_HMECs_Human0.76774666
148CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.76577243
149PU.1_20513432_ChIP-Seq_Bcells_Mouse0.76417067
150RING1B_27294783_Chip-Seq_NPCs_Mouse0.75628939
151EED_16625203_ChIP-ChIP_MESCs_Mouse0.75551154
152* GATA1_19941826_ChIP-Seq_K562_Human0.74733837
153KLF5_25053715_ChIP-Seq_YYC3_Human0.74527460
154RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.73583712
155FOXM1_26456572_ChIP-Seq_MCF-7_Human0.73360004
156* GATA2_19941826_ChIP-Seq_K562_Human0.73096743
157SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.72047354
158FOXA1_25552417_ChIP-Seq_VCAP_Human0.71819984
159SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.71304651
160* LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.71293671
161POU5F1_16153702_ChIP-ChIP_HESCs_Human0.70772775

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog4.58941184
2MP0002254_reproductive_system_inflammat4.42237991
3MP0003303_peritoneal_inflammation4.21222098
4MP0002009_preneoplasia3.38650948
5MP0001346_abnormal_lacrimal_gland3.31079732
6MP0008789_abnormal_olfactory_epithelium3.30388849
7MP0000678_abnormal_parathyroid_gland2.97939316
8MP0005394_taste/olfaction_phenotype2.84958895
9MP0005499_abnormal_olfactory_system2.84958895
10MP0000685_abnormal_immune_system2.78518955
11MP0003724_increased_susceptibility_to2.71388212
12MP0002132_abnormal_respiratory_system2.64780631
13MP0005646_abnormal_pituitary_gland2.56295065
14MP0009785_altered_susceptibility_to2.50846597
15MP0005025_abnormal_response_to2.48914123
16MP0003828_pulmonary_edema2.35515821
17MP0002420_abnormal_adaptive_immunity2.30628513
18MP0001819_abnormal_immune_cell2.27500432
19MP0010030_abnormal_orbit_morphology2.22071585
20MP0000613_abnormal_salivary_gland2.14626068
21MP0002138_abnormal_hepatobiliary_system2.09165958
22MP0009379_abnormal_foot_pigmentation2.02396781
23MP0009278_abnormal_bone_marrow1.93969030
24MP0003941_abnormal_skin_development1.90813044
25MP0002060_abnormal_skin_morphology1.83411374
26MP0004883_abnormal_blood_vessel1.83138249
27MP0006082_CNS_inflammation1.81445195
28MP0002277_abnormal_respiratory_mucosa1.78890173
29MP0004510_myositis1.77747606
30MP0010368_abnormal_lymphatic_system1.77351808
31MP0000716_abnormal_immune_system1.76844766
32MP0002398_abnormal_bone_marrow1.74220534
33MP0004264_abnormal_extraembryonic_tissu1.73305525
34MP0000762_abnormal_tongue_morphology1.72036574
35MP0002098_abnormal_vibrissa_morphology1.70684680
36MP0000566_synostosis1.65652055
37MP0009333_abnormal_splenocyte_physiolog1.64831370
38MP0008004_abnormal_stomach_pH1.64011883
39MP0001853_heart_inflammation1.55491834
40MP0005310_abnormal_salivary_gland1.50489856
41MP0003763_abnormal_thymus_physiology1.50227792
42MP0002405_respiratory_system_inflammati1.49586328
43MP0009780_abnormal_chondrocyte_physiolo1.49234095
44MP0001873_stomach_inflammation1.48303936
45MP0000689_abnormal_spleen_morphology1.45521102
46MP0009764_decreased_sensitivity_to1.45112944
47MP0001919_abnormal_reproductive_system1.40750415
48MP0002722_abnormal_immune_system1.39963485
49MP0000049_abnormal_middle_ear1.37607524
50MP0000467_abnormal_esophagus_morphology1.34849550
51MP0003866_abnormal_defecation1.34305927
52MP0002429_abnormal_blood_cell1.34098999
53MP0002148_abnormal_hypersensitivity_rea1.31910461
54MP0004947_skin_inflammation1.30892749
55MP0000703_abnormal_thymus_morphology1.29617289
56MP0008469_abnormal_protein_level1.29201153
57MP0005023_abnormal_wound_healing1.25253924
58MP0001188_hyperpigmentation1.24841978
59MP0009840_abnormal_foam_cell1.24327453
60MP0005464_abnormal_platelet_physiology1.23866232
61MP0004381_abnormal_hair_follicle1.22422022
62MP0003300_gastrointestinal_ulcer1.21941052
63MP0008007_abnormal_cellular_replicative1.21308255
64MP0003172_abnormal_lysosome_physiology1.20957940
65MP0003453_abnormal_keratinocyte_physiol1.19871043
66MP0003045_fibrosis1.17670586
67MP0003656_abnormal_erythrocyte_physiolo1.16832049
68MP0008995_early_reproductive_senescence1.16528657
69MP0005166_decreased_susceptibility_to1.15610064
70MP0001835_abnormal_antigen_presentation1.11193079
71MP0001984_abnormal_olfaction1.10900867
72MP0000383_abnormal_hair_follicle1.10814183
73MP0003191_abnormal_cellular_cholesterol1.10360450
74MP0001790_abnormal_immune_system1.10139971
75MP0005387_immune_system_phenotype1.10139971
76MP0001270_distended_abdomen1.09923371
77MP0005000_abnormal_immune_tolerance1.06612931
78MP0003436_decreased_susceptibility_to1.06058022
79MP0005164_abnormal_response_to1.05441360
80MP0003786_premature_aging1.05346654
81MP0005167_abnormal_blood-brain_barrier1.04553208
82MP0002090_abnormal_vision1.03890113
83MP0004782_abnormal_surfactant_physiolog1.03678252
84MP0005058_abnormal_lysosome_morphology1.02458030
85MP0001879_abnormal_lymphatic_vessel1.01810041
86MP0002233_abnormal_nose_morphology1.01097168
87MP0000858_altered_metastatic_potential1.00890042
88MP0005390_skeleton_phenotype1.00740667
89MP0005451_abnormal_body_composition1.00454124
90MP0006292_abnormal_olfactory_placode1.00253846
91MP0008961_abnormal_basal_metabolism0.99336496
92MP0002166_altered_tumor_susceptibility0.98288609
93MP0000372_irregular_coat_pigmentation0.96879552
94MP0001533_abnormal_skeleton_physiology0.95436393
95MP0005508_abnormal_skeleton_morphology0.95287459
96MP0006072_abnormal_retinal_apoptosis0.95048275
97MP0001216_abnormal_epidermal_layer0.94807295
98MP0000249_abnormal_blood_vessel0.94596913
99MP0001851_eye_inflammation0.93956492
100MP0008260_abnormal_autophagy0.93697806
101MP0002419_abnormal_innate_immunity0.92957191
102MP0003091_abnormal_cell_migration0.90471188
103MP0003279_aneurysm0.90004898
104MP0003943_abnormal_hepatobiliary_system0.88886147
105MP0000465_gastrointestinal_hemorrhage0.88782733
106MP0000343_altered_response_to0.87920931
107MP0001191_abnormal_skin_condition0.87550810
108MP0010386_abnormal_urinary_bladder0.85507694
109MP0005408_hypopigmentation0.85470932
110MP0002006_tumorigenesis0.85400940
111MP0010155_abnormal_intestine_physiology0.84897760
112MP0002998_abnormal_bone_remodeling0.84628566
113MP0001800_abnormal_humoral_immune0.84573114
114MP0001501_abnormal_sleep_pattern0.82958490
115MP0001944_abnormal_pancreas_morphology0.82258793
116MP0005275_abnormal_skin_tensile0.81348310
117MP0000604_amyloidosis0.80466004
118MP0005671_abnormal_response_to0.80249255
119MP0000681_abnormal_thyroid_gland0.80134932
120MP0005409_darkened_coat_color0.80134150
121MP0002452_abnormal_antigen_presenting0.79572032
122MP0005670_abnormal_white_adipose0.79151784
123MP0003690_abnormal_glial_cell0.78987635
124MP0003183_abnormal_peptide_metabolism0.78937022
125MP0003075_altered_response_to0.78730110
126MP0004808_abnormal_hematopoietic_stem0.78462010
127MP0001663_abnormal_digestive_system0.77878477
128MP0002249_abnormal_larynx_morphology0.77817302
129MP0002896_abnormal_bone_mineralization0.75743773
130MP0000538_abnormal_urinary_bladder0.75617173
131MP0002177_abnormal_outer_ear0.75602676
132MP0002933_joint_inflammation0.75587803
133MP0002723_abnormal_immune_serum0.74603409
134MP0003795_abnormal_bone_structure0.74388553
135MP0002396_abnormal_hematopoietic_system0.74140517
136MP0005397_hematopoietic_system_phenotyp0.73711481
137MP0001545_abnormal_hematopoietic_system0.73711481
138MP0002693_abnormal_pancreas_physiology0.72775636
139MP0005248_abnormal_Harderian_gland0.72610527
140MP0001186_pigmentation_phenotype0.72044615
141MP0008875_abnormal_xenobiotic_pharmacok0.71724591
142MP0000631_abnormal_neuroendocrine_gland0.70447890
143MP0004272_abnormal_basement_membrane0.69464935
144MP0001845_abnormal_inflammatory_respons0.69236977
145MP0009115_abnormal_fat_cell0.68880483
146MP0009763_increased_sensitivity_to0.68308765
147MP0002928_abnormal_bile_duct0.67938564
148MP0003448_altered_tumor_morphology0.67840134
149MP0005535_abnormal_body_temperature0.66517653
150MP0002332_abnormal_exercise_endurance0.65407879
151MP0004484_altered_response_of0.61070332
152MP0009765_abnormal_xenobiotic_induced0.59023494
153MP0005076_abnormal_cell_differentiation0.58933138
154MP0002136_abnormal_kidney_physiology0.58630107
155MP0004130_abnormal_muscle_cell0.55407711
156MP0001986_abnormal_taste_sensitivity0.55333474

Predicted human phenotypes

RankGene SetZ-score
1Stomach cancer (HP:0012126)5.99723224
2Prostate neoplasm (HP:0100787)5.15063012
3Lip pit (HP:0100267)5.11464305
4Urethral obstruction (HP:0000796)4.95089509
5Stomatitis (HP:0010280)4.88702987
6Elevated erythrocyte sedimentation rate (HP:0003565)4.47410283
7Myositis (HP:0100614)4.41487886
8Abnormality of macrophages (HP:0004311)4.22241422
9Orchitis (HP:0100796)4.19493574
10Recurrent bacterial skin infections (HP:0005406)4.12528690
11Recurrent abscess formation (HP:0002722)3.96347795
12Mediastinal lymphadenopathy (HP:0100721)3.88586227
13Vasculitis (HP:0002633)3.80470658
14Abnormal delayed hypersensitivity skin test (HP:0002963)3.63107332
15Increased IgE level (HP:0003212)3.57443845
16Recurrent fungal infections (HP:0002841)3.57394933
17Eczematoid dermatitis (HP:0000976)3.57257564
18Meningitis (HP:0001287)3.55818153
19Spontaneous hematomas (HP:0007420)3.53213941
20Distal lower limb muscle weakness (HP:0009053)3.48884338
21Alopecia of scalp (HP:0002293)3.48086973
22Recurrent gram-negative bacterial infections (HP:0005420)3.44031480
23Gastrointestinal stroma tumor (HP:0100723)3.26287152
24Gastrointestinal infarctions (HP:0005244)3.24450384
25Pulmonary infiltrates (HP:0002113)3.20470442
26Keratoconjunctivitis sicca (HP:0001097)3.10064653
27Bifid scrotum (HP:0000048)3.08096796
28Increased CSF protein (HP:0002922)3.05652721
29Chronic mucocutaneous candidiasis (HP:0002728)3.02008916
30Recurrent cutaneous fungal infections (HP:0011370)3.02008916
31Systemic lupus erythematosus (HP:0002725)2.99710882
32Recurrent viral infections (HP:0004429)2.99464839
33Ulnar claw (HP:0001178)2.99134244
34Growth hormone excess (HP:0000845)2.98452688
35Recurrent skin infections (HP:0001581)2.96775725
36Cupped ear (HP:0000378)2.90177313
37Alveolar cell carcinoma (HP:0006519)2.89590787
38Keratoconjunctivitis (HP:0001096)2.89024366
39Median cleft lip (HP:0000161)2.87444744
40Encephalitis (HP:0002383)2.87141966
41Hemoptysis (HP:0002105)2.80045687
42Cellulitis (HP:0100658)2.79542004
43Chronic obstructive pulmonary disease (HP:0006510)2.78341933
44Obstructive lung disease (HP:0006536)2.78341933
45Agammaglobulinemia (HP:0004432)2.78025728
46Colitis (HP:0002583)2.75095831
47Abnormality of the nasal septum (HP:0000419)2.74299802
48Panhypogammaglobulinemia (HP:0003139)2.73752235
49Inflammation of the large intestine (HP:0002037)2.73385850
50Upper limb muscle weakness (HP:0003484)2.72443867
51Abnormality of cochlea (HP:0000375)2.69483798
52Hematochezia (HP:0002573)2.68963863
53Aplasia involving bones of the extremities (HP:0009825)2.68713688
54Aplasia involving bones of the upper limbs (HP:0009823)2.68713688
55Aplasia of the phalanges of the hand (HP:0009802)2.68713688
56Recurrent bronchitis (HP:0002837)2.68543017
57Neoplasm of the tracheobronchial system (HP:0100552)2.66910565
58T lymphocytopenia (HP:0005403)2.66668619
59Abnormality of the prostate (HP:0008775)2.65955987
60Abnormality of the distal phalanges of the toes (HP:0010182)2.65729618
61Abnormality of T cell number (HP:0011839)2.63619320
62Lymphopenia (HP:0001888)2.61463972
63Leukocytosis (HP:0001974)2.61143058
64Urticaria (HP:0001025)2.60021558
65Gingivitis (HP:0000230)2.59349524
66Gastrointestinal inflammation (HP:0004386)2.58420909
67Autoimmune thrombocytopenia (HP:0001973)2.58258864
68Restrictive lung disease (HP:0002091)2.54305589
69Abnormality of the fingertips (HP:0001211)2.53678385
70Autoimmune hemolytic anemia (HP:0001890)2.52309848
71Episodic fever (HP:0001954)2.51138242
72Chest pain (HP:0100749)2.50852181
73Abnormality of T cells (HP:0002843)2.48967171
74Intestinal atresia (HP:0011100)2.48837818
75Fatigue (HP:0012378)2.48739704
76Down-sloping shoulders (HP:0200021)2.48698300
77Segmental peripheral demyelination/remyelination (HP:0003481)2.46997221
78Recurrent sinusitis (HP:0011108)2.46856140
79Papilledema (HP:0001085)2.46434679
80Abnormality of cells of the lymphoid lineage (HP:0012140)2.46088573
81Pustule (HP:0200039)2.42568203
82Osteomyelitis (HP:0002754)2.42001561
83Sparse scalp hair (HP:0002209)2.39662286
84Abnormality of the pleura (HP:0002103)2.39200205
85Follicular hyperkeratosis (HP:0007502)2.37250305
86Abnormality of T cell physiology (HP:0011840)2.35948373
87Absent eyebrow (HP:0002223)2.34228043
88Prolonged bleeding time (HP:0003010)2.33683819
89Abnormality of the axillary hair (HP:0100134)2.32246854
90Abnormality of secondary sexual hair (HP:0009888)2.32246854
91Popliteal pterygium (HP:0009756)2.30448078
92Pulmonary embolism (HP:0002204)2.28889088
93Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.27963931
94Preauricular pit (HP:0004467)2.25575099
95Periauricular skin pits (HP:0100277)2.25575099
96Arterial thrombosis (HP:0004420)2.25445218
97Long clavicles (HP:0000890)2.25151601
98Emphysema (HP:0002097)2.24940243
99True hermaphroditism (HP:0010459)2.23560273
100Hypergammaglobulinemia (HP:0010702)2.22094946
101Joint swelling (HP:0001386)2.20867387
102Chronic diarrhea (HP:0002028)2.18778675
103Hyperactive renin-angiotensin system (HP:0000841)2.16400926
104Abnormality of the renal collecting system (HP:0004742)2.16322760
105Papilloma (HP:0012740)2.15600124
106Verrucae (HP:0200043)2.15600124
107Granulocytopenia (HP:0001913)2.14033461
108Dysostosis multiplex (HP:0000943)2.14014616
109Gangrene (HP:0100758)2.12756941
110Abnormality of male internal genitalia (HP:0000022)2.09946098
111Abnormality of liposaccharide metabolism (HP:0010968)2.09630902
112Abnormality of glycosphingolipid metabolism (HP:0004343)2.09630902
113Abnormality of glycolipid metabolism (HP:0010969)2.09630902
114Chronic otitis media (HP:0000389)2.08527639
115Congenital, generalized hypertrichosis (HP:0004540)2.08224636
116Amyloidosis (HP:0011034)2.07530659
117Onycholysis (HP:0001806)2.06866778
118Increased IgM level (HP:0003496)2.06697819
119Epistaxis (HP:0000421)2.05533846
120Milia (HP:0001056)2.04571105
121Peripheral hypomyelination (HP:0007182)2.04418219
122White forelock (HP:0002211)2.04414429
123Sepsis (HP:0100806)2.02510596
124Eosinophilia (HP:0001880)2.01944766
125Submucous cleft hard palate (HP:0000176)2.01890404
126Malnutrition (HP:0004395)2.01842241
127Glomerulonephritis (HP:0000099)2.00528694
128Hypoplastic scapulae (HP:0000882)1.99407145
129Aplasia/Hypoplasia of the scapulae (HP:0006713)1.99407145
130IgG deficiency (HP:0004315)1.99010643
131Arthralgia (HP:0002829)1.98217063
132Plantar hyperkeratosis (HP:0007556)1.97490440
133Osteomalacia (HP:0002749)1.96720785
134Vacuolated lymphocytes (HP:0001922)1.96484425
135Redundant skin (HP:0001582)1.96203484
136Hypoplastic labia majora (HP:0000059)1.95690529
137IgM deficiency (HP:0002850)1.95063817
138Loss of speech (HP:0002371)1.95055663
139Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.94631563
140Slow saccadic eye movements (HP:0000514)1.94023861
141Osteolytic defects of the hand bones (HP:0009699)1.92726768
142Osteolytic defects of the phalanges of the hand (HP:0009771)1.92726768
143Thick nail (HP:0001805)1.92132428
144Cheilitis (HP:0100825)1.91550742
145Gastrointestinal atresia (HP:0002589)1.91401741
146Nasolacrimal duct obstruction (HP:0000579)1.90965295
147Increased cerebral lipofuscin (HP:0011813)1.90841123
148Abnormality of incisor morphology (HP:0011063)1.89127413
149Interstitial pulmonary disease (HP:0006530)1.88870002
150Renal cortical cysts (HP:0000803)1.88824923
151Gingival bleeding (HP:0000225)1.88427519
152Natal tooth (HP:0000695)1.87266515
153Acne (HP:0001061)1.86462225
154Cerebral palsy (HP:0100021)1.84935410
155Decreased circulating renin level (HP:0003351)1.84443528
156Patchy hypopigmentation of hair (HP:0011365)1.83887449
157Hypoplasia of the fovea (HP:0007750)1.82403422
158Aplasia/Hypoplasia of the fovea (HP:0008060)1.82403422
159Hydroureter (HP:0000072)1.81794607
160Progressive visual loss (HP:0000529)1.81120065
161Atrophic scars (HP:0001075)1.81092577
162Symptomatic seizures (HP:0011145)1.79168883
163Congenital sensorineural hearing impairment (HP:0008527)1.76340495
164Hypoglycemic seizures (HP:0002173)1.75664668
165Morphological abnormality of the middle ear (HP:0008609)1.74060207
166Increased neuronal autofluorescent lipopigment (HP:0002074)1.73966914
167Abnormality of the labia majora (HP:0012881)1.73940533
168Skin pits (HP:0100276)1.73569092
169Abnormality of the lacrimal duct (HP:0011481)1.72763082
170Abnormality of chloride homeostasis (HP:0011422)1.72387747
171Palmoplantar hyperkeratosis (HP:0000972)1.71644553
172Hypoplasia of the uterus (HP:0000013)1.70221672
173Right ventricular cardiomyopathy (HP:0011663)1.69615448
174Mucopolysacchariduria (HP:0008155)1.68200879
175Urinary glycosaminoglycan excretion (HP:0003541)1.68200879
176Palmar hyperkeratosis (HP:0010765)1.67914918
177Abnormality of the nasolacrimal system (HP:0000614)1.66718258
178Aplasia/hypoplasia of the uterus (HP:0008684)1.66395642
179Dysautonomia (HP:0002459)1.65018304
180Male pseudohermaphroditism (HP:0000037)1.64829574
181Hyperglycemia (HP:0003074)1.64226900
18211 pairs of ribs (HP:0000878)1.62689054
183Glomerulopathy (HP:0100820)1.62479044
184Neoplasm of the lung (HP:0100526)1.62356827
185Dry hair (HP:0011359)1.61807086
186Hypoplasia of dental enamel (HP:0006297)1.61354253
187Optic neuritis (HP:0100653)1.61211418
188Retrobulbar optic neuritis (HP:0100654)1.61211418
189Adactyly (HP:0009776)1.59689951
190Abnormality of glycosaminoglycan metabolism (HP:0004371)1.58258891

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK155.37648683
2MAP2K23.50399200
3MAP3K33.16007109
4RIPK43.10023490
5TGFBR22.46370262
6MAP3K142.38959419
7MAP3K22.27865919
8ERN12.27178188
9INSRR2.23574520
10ZAK2.21528078
11BLK2.17964296
12PDK22.15762411
13NEK62.05721206
14MAPK71.99939296
15IKBKB1.95400254
16TXK1.93132255
17HIPK21.77568008
18NLK1.75923837
19ERBB31.74886466
20EPHA31.72491050
21MAP3K131.64741684
22CHUK1.62156736
23FES1.53668036
24IKBKE1.52869392
25IRAK31.52682964
26MST41.49712394
27EPHA21.49465708
28TAOK21.48975991
29GRK71.47931629
30MAPKAPK51.43688080
31BMPR21.41526614
32TRPM71.41301389
33PRPF4B1.39272610
34SIK31.36538683
35BMPR1B1.36367919
36TAOK11.34594380
37FRK1.28559569
38CDK121.26596250
39SYK1.26498679
40HCK1.24711507
41CDK31.24383824
42GRK61.23756820
43ITK1.22317058
44ADRBK21.20900803
45VRK11.19172981
46RPS6KB21.11983552
47IRAK21.11608922
48CDK81.10288324
49NUAK11.07356884
50TEC1.06398030
51LYN1.06118509
52JAK21.05420059
53FER1.05219424
54SGK21.05106220
55SIK21.04595452
56TYK21.04301373
57IRAK41.01920621
58BRD41.00070831
59LCK0.99372173
60CASK0.94716497
61TSSK60.94425749
62CDC42BPA0.93945436
63MARK20.93687733
64IRAK10.92566472
65PASK0.92161822
66SIK10.92152548
67MAP2K30.91753062
68KIT0.91521653
69MAPKAPK20.91163830
70MARK30.91118083
71CSF1R0.89728912
72MAPK120.88272647
73RPS6KA20.87428368
74TIE10.86992031
75EPHB20.86381096
76RPS6KA60.85025222
77RPS6KC10.84903038
78RPS6KL10.84903038
79MAP3K70.84731721
80MAP3K110.84388369
81EPHB10.81825623
82STK100.81244935
83MATK0.78091306
84BTK0.77502280
85MAP3K100.76522796
86FGR0.76152464
87STK240.75976930
88NEK90.75493944
89PRKD20.74757002
90TRIB30.74694147
91PIM10.73649694
92RPS6KA50.72429595
93PIM20.70397615
94PDK10.67255261
95KSR20.65259214
96CAMKK10.64292086
97JAK10.63784967
98MAP2K10.62293865
99TGFBR10.60553738
100SGK30.59901431
101TBK10.59883715
102TNK20.59861622
103PRKCQ0.58999079
104EIF2AK20.58517816
105FGFR30.57925227
106MKNK20.57332518
107MAP4K10.56573927
108ZAP700.54816402
109PDPK10.54748426
110YES10.53995455
111GSK3A0.53641052
112SGK2230.53469047
113SGK4940.53469047
114CDK90.52779513
115TAOK30.51847541
116MAPK40.51324487
117* MAPK30.51119483
118FGFR40.51073391
119MYLK0.50887933
120RPS6KA40.50770282
121DMPK0.48315739
122GRK10.48078491
123RIPK10.47431029
124LMTK20.45904121
125PDGFRB0.45892190
126PRKCE0.44414335
127STK38L0.44259864
128DAPK20.44218700
129RPS6KA10.44123466
130MAP3K50.44076318
131PIK3CG0.43494531
132JAK30.42834841
133PIK3CA0.41517574
134CSK0.40933537
135MAPK110.39336168
136MAP3K10.39308168
137PRKG20.39274391
138MAP2K60.38811239
139CDK60.37691868
140LATS10.37524325
141DYRK1B0.35949810
142LRRK20.34267706
143STK110.33357529

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.33390117
2Pentose and glucuronate interconversions_Homo sapiens_hsa000402.66926912
3Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.66321883
4Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.49230771
5Allograft rejection_Homo sapiens_hsa053302.45408310
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.44682763
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.42468808
8Autoimmune thyroid disease_Homo sapiens_hsa053202.28592668
9Type I diabetes mellitus_Homo sapiens_hsa049402.14132841
10Chemical carcinogenesis_Homo sapiens_hsa052042.10047104
11Sulfur metabolism_Homo sapiens_hsa009202.06680612
12Steroid hormone biosynthesis_Homo sapiens_hsa001402.02203574
13Circadian rhythm_Homo sapiens_hsa047101.84448695
14Asthma_Homo sapiens_hsa053101.81748435
15Leishmaniasis_Homo sapiens_hsa051401.75755744
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.75193303
17Tuberculosis_Homo sapiens_hsa051521.66830670
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.61522728
19Starch and sucrose metabolism_Homo sapiens_hsa005001.58975212
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.54718354
21Osteoclast differentiation_Homo sapiens_hsa043801.53600925
22TNF signaling pathway_Homo sapiens_hsa046681.47379667
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.43288985
24Viral myocarditis_Homo sapiens_hsa054161.33576419
25Toll-like receptor signaling pathway_Homo sapiens_hsa046201.32937547
26Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.31618108
27Protein export_Homo sapiens_hsa030601.28556182
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.27308185
29Rheumatoid arthritis_Homo sapiens_hsa053231.24645472
30Retinol metabolism_Homo sapiens_hsa008301.23523348
31Galactose metabolism_Homo sapiens_hsa000521.23110095
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.22473109
33Prostate cancer_Homo sapiens_hsa052151.16776717
34AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.16411572
35Prolactin signaling pathway_Homo sapiens_hsa049171.16102880
36Transcriptional misregulation in cancer_Homo sapiens_hsa052021.14964547
37Notch signaling pathway_Homo sapiens_hsa043301.13870181
38Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.13315043
39Other glycan degradation_Homo sapiens_hsa005111.13132486
40B cell receptor signaling pathway_Homo sapiens_hsa046621.10562847
41Pertussis_Homo sapiens_hsa051331.08552920
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.07176860
43Prion diseases_Homo sapiens_hsa050201.03032842
44Toxoplasmosis_Homo sapiens_hsa051451.01691445
45Hematopoietic cell lineage_Homo sapiens_hsa046401.01364346
46Adherens junction_Homo sapiens_hsa045201.00533134
47Type II diabetes mellitus_Homo sapiens_hsa049300.97860986
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.97826351
49T cell receptor signaling pathway_Homo sapiens_hsa046600.96471969
50Legionellosis_Homo sapiens_hsa051340.95278912
51Apoptosis_Homo sapiens_hsa042100.95218930
52Intestinal immune network for IgA production_Homo sapiens_hsa046720.94895033
53Arachidonic acid metabolism_Homo sapiens_hsa005900.94180832
54Renal cell carcinoma_Homo sapiens_hsa052110.92686943
55ABC transporters_Homo sapiens_hsa020100.91889424
56HTLV-I infection_Homo sapiens_hsa051660.91317457
57Hepatitis B_Homo sapiens_hsa051610.90687454
58Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.88807295
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.87783128
60Non-small cell lung cancer_Homo sapiens_hsa052230.86780522
61Measles_Homo sapiens_hsa051620.86587683
62Herpes simplex infection_Homo sapiens_hsa051680.86476305
63NOD-like receptor signaling pathway_Homo sapiens_hsa046210.85218194
64Jak-STAT signaling pathway_Homo sapiens_hsa046300.84827405
65Staphylococcus aureus infection_Homo sapiens_hsa051500.84691560
66Influenza A_Homo sapiens_hsa051640.84444562
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.84054489
68Primary immunodeficiency_Homo sapiens_hsa053400.82819212
69Dorso-ventral axis formation_Homo sapiens_hsa043200.81057569
70Pancreatic cancer_Homo sapiens_hsa052120.78225751
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77930265
72Glutathione metabolism_Homo sapiens_hsa004800.77486507
73VEGF signaling pathway_Homo sapiens_hsa043700.76854193
74Antigen processing and presentation_Homo sapiens_hsa046120.76498316
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75741038
76TGF-beta signaling pathway_Homo sapiens_hsa043500.74995654
77Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.71863948
78Graft-versus-host disease_Homo sapiens_hsa053320.71386377
79Leukocyte transendothelial migration_Homo sapiens_hsa046700.69680957
80FoxO signaling pathway_Homo sapiens_hsa040680.68896684
81Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66960835
82GnRH signaling pathway_Homo sapiens_hsa049120.66430841
83Epstein-Barr virus infection_Homo sapiens_hsa051690.65406933
84Malaria_Homo sapiens_hsa051440.63945922
85Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.63863773
86Lysosome_Homo sapiens_hsa041420.61633792
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.61407283
88Shigellosis_Homo sapiens_hsa051310.61381178
89Choline metabolism in cancer_Homo sapiens_hsa052310.59858100
90ECM-receptor interaction_Homo sapiens_hsa045120.58421437
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.58186319
92Cocaine addiction_Homo sapiens_hsa050300.57711626
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57445197
94Chronic myeloid leukemia_Homo sapiens_hsa052200.57068601
95mTOR signaling pathway_Homo sapiens_hsa041500.56921799
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56500422
97MAPK signaling pathway_Homo sapiens_hsa040100.56208590
98Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55423980
99Hepatitis C_Homo sapiens_hsa051600.55303414
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54829522
101Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54391226
102Viral carcinogenesis_Homo sapiens_hsa052030.54170711
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53684276
104Acute myeloid leukemia_Homo sapiens_hsa052210.52618600
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52377317
106Estrogen signaling pathway_Homo sapiens_hsa049150.52313403
107RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.50863572
108Colorectal cancer_Homo sapiens_hsa052100.49913567
109HIF-1 signaling pathway_Homo sapiens_hsa040660.49907627
110Phospholipase D signaling pathway_Homo sapiens_hsa040720.49220744
111Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49193729
112Chemokine signaling pathway_Homo sapiens_hsa040620.48067081
113African trypanosomiasis_Homo sapiens_hsa051430.48041793
114Vibrio cholerae infection_Homo sapiens_hsa051100.46750841
115Inositol phosphate metabolism_Homo sapiens_hsa005620.45274402
116Thyroid cancer_Homo sapiens_hsa052160.45133214
117Insulin resistance_Homo sapiens_hsa049310.45021879
118Small cell lung cancer_Homo sapiens_hsa052220.44700623
119Pathways in cancer_Homo sapiens_hsa052000.42579002
120Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41871158
121ErbB signaling pathway_Homo sapiens_hsa040120.41756618
122Endometrial cancer_Homo sapiens_hsa052130.40794633
123Complement and coagulation cascades_Homo sapiens_hsa046100.40780018
124Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.40458155
125Amphetamine addiction_Homo sapiens_hsa050310.40062776
126Salmonella infection_Homo sapiens_hsa051320.39366238
127Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38844705
128Vitamin digestion and absorption_Homo sapiens_hsa049770.38810880
129Pancreatic secretion_Homo sapiens_hsa049720.38546039
130Amoebiasis_Homo sapiens_hsa051460.37568982
131Phagosome_Homo sapiens_hsa041450.36739635
132Insulin secretion_Homo sapiens_hsa049110.36024493
133Platelet activation_Homo sapiens_hsa046110.35685371
134Insulin signaling pathway_Homo sapiens_hsa049100.34910159
135Endocytosis_Homo sapiens_hsa041440.31438980

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