BTG3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein might play a role in neurogenesis in the central nervous system. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)7.49678532
2COPI coating of Golgi vesicle (GO:0048205)7.49678532
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.06732231
4protein retention in ER lumen (GO:0006621)4.57773376
5ribosomal small subunit assembly (GO:0000028)4.30736411
6signal peptide processing (GO:0006465)4.06576163
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.88860507
8chromatin remodeling at centromere (GO:0031055)3.79229480
9COPII vesicle coating (GO:0048208)3.76692570
10protein targeting to ER (GO:0045047)3.75750171
11positive regulation of mitochondrial fission (GO:0090141)3.73501904
12protein K6-linked ubiquitination (GO:0085020)3.71698836
13CENP-A containing nucleosome assembly (GO:0034080)3.69592247
14cotranslational protein targeting to membrane (GO:0006613)3.69223998
15retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.68032206
16establishment of protein localization to endoplasmic reticulum (GO:0072599)3.56086423
17proteasome assembly (GO:0043248)3.53298654
18formation of translation preinitiation complex (GO:0001731)3.52707792
19positive regulation of nuclease activity (GO:0032075)3.51983190
20protein localization to endoplasmic reticulum (GO:0070972)3.51452957
21activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.50514731
22regulation of DNA endoreduplication (GO:0032875)3.47134339
23kinetochore organization (GO:0051383)3.46317081
24male meiosis I (GO:0007141)3.45246178
25cullin deneddylation (GO:0010388)3.34992731
26regulation of nuclease activity (GO:0032069)3.33165670
27folic acid-containing compound biosynthetic process (GO:0009396)3.27536870
28antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.26573375
29antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.26573375
30regulation of meiosis I (GO:0060631)3.26363284
31intraciliary transport (GO:0042073)3.23845539
32nonmotile primary cilium assembly (GO:0035058)3.19231601
33endoplasmic reticulum unfolded protein response (GO:0030968)3.14598428
34mitotic metaphase plate congression (GO:0007080)3.13665051
35mitotic chromosome condensation (GO:0007076)3.13035615
36translational termination (GO:0006415)3.12801141
37establishment of protein localization to mitochondrial membrane (GO:0090151)3.09963639
38DNA ligation (GO:0006266)3.09325066
39metaphase plate congression (GO:0051310)3.08227947
40viral transcription (GO:0019083)3.07672428
41protein deneddylation (GO:0000338)3.06015866
42cellular response to unfolded protein (GO:0034620)3.03726878
43synapsis (GO:0007129)3.02069997
44piRNA metabolic process (GO:0034587)3.01961908
45meiotic chromosome segregation (GO:0045132)2.99849833
46meiosis I (GO:0007127)2.97769300
47kinetochore assembly (GO:0051382)2.97566138
48deoxyribonucleotide biosynthetic process (GO:0009263)2.96823235
49antigen processing and presentation via MHC class Ib (GO:0002475)2.96714813
50telomere maintenance via semi-conservative replication (GO:0032201)2.93447089
51maturation of SSU-rRNA (GO:0030490)2.92756576
52cellular response to topologically incorrect protein (GO:0035967)2.92054165
53postreplication repair (GO:0006301)2.90493397
54protein-cofactor linkage (GO:0018065)2.88715852
55production of molecular mediator involved in inflammatory response (GO:0002532)2.87607698
56DNA deamination (GO:0045006)2.87045601
57histone exchange (GO:0043486)2.84656733
58nucleotide-excision repair, DNA gap filling (GO:0006297)2.84280569
59negative regulation of glycoprotein biosynthetic process (GO:0010561)2.82759316
60deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.80198875
61translesion synthesis (GO:0019985)2.79217944
62sequestering of metal ion (GO:0051238)2.78395295
63mitotic sister chromatid segregation (GO:0000070)2.78087965
64translational elongation (GO:0006414)2.76609682
65ER-nucleus signaling pathway (GO:0006984)2.76439932
66pteridine-containing compound biosynthetic process (GO:0042559)2.76339629
67regulation of type B pancreatic cell apoptotic process (GO:2000674)2.76304722
68regulation of cilium movement (GO:0003352)2.76256766
69RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.73533140
70tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.73533140
71replication fork processing (GO:0031297)2.72445958
72protein K11-linked ubiquitination (GO:0070979)2.72172213
73vesicle coating (GO:0006901)2.72021830
74regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.71874745
75water-soluble vitamin biosynthetic process (GO:0042364)2.70953373
76UDP-N-acetylglucosamine metabolic process (GO:0006047)2.70823146
77cellular response to vitamin D (GO:0071305)2.69942654
78nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.65732301
79protein maturation by protein folding (GO:0022417)2.65576738
80negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.64811420
81translational initiation (GO:0006413)2.64729658
82exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.64167264
83L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.63574480
84sister chromatid segregation (GO:0000819)2.62426198
85nucleotide-sugar biosynthetic process (GO:0009226)2.61198664
86nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.60050486
87mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.59296407
88mitochondrial respiratory chain complex I assembly (GO:0032981)2.59296407
89NADH dehydrogenase complex assembly (GO:0010257)2.59296407
90negative regulation of meiosis (GO:0045835)2.58699991
91centriole replication (GO:0007099)2.58608582
92DNA strand elongation involved in DNA replication (GO:0006271)2.57876802
93pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.57729957
94protein complex biogenesis (GO:0070271)2.57263364
95viral life cycle (GO:0019058)2.56787686
96protein neddylation (GO:0045116)2.56670769
97resolution of meiotic recombination intermediates (GO:0000712)2.56660850
98GDP-mannose metabolic process (GO:0019673)2.55971217
99DNA replication-independent nucleosome organization (GO:0034724)2.55352934
100DNA replication-independent nucleosome assembly (GO:0006336)2.55352934
101antigen processing and presentation of endogenous antigen (GO:0019883)2.54806126
102protein localization to cilium (GO:0061512)2.53918626
103regulation of sister chromatid cohesion (GO:0007063)2.53551368
104mitochondrial respiratory chain complex assembly (GO:0033108)2.52897293
105chaperone-mediated protein transport (GO:0072321)2.52817913
106protein autoprocessing (GO:0016540)2.52088305
107protein targeting to membrane (GO:0006612)2.51873437
108keratan sulfate catabolic process (GO:0042340)2.50757095
109DNA strand elongation (GO:0022616)2.49844210
110platelet dense granule organization (GO:0060155)2.48800819
111positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.48778461
112mitotic recombination (GO:0006312)2.48204069
113negative regulation of erythrocyte differentiation (GO:0045647)2.47640137
114regulation of chronic inflammatory response (GO:0002676)2.46970917
115regulation of apoptotic process involved in morphogenesis (GO:1902337)2.46769675
116negative regulation of membrane potential (GO:0045837)2.46517513
117dosage compensation (GO:0007549)2.46457818
118attachment of spindle microtubules to kinetochore (GO:0008608)2.46386365
119radial glial cell differentiation (GO:0060019)2.46060290
120telomere maintenance via recombination (GO:0000722)2.45997776
121response to endoplasmic reticulum stress (GO:0034976)2.45926394
122DNA replication checkpoint (GO:0000076)2.44924274
123outer ear morphogenesis (GO:0042473)2.44710861
124protein localization to chromosome, centromeric region (GO:0071459)2.44355076
125IMP biosynthetic process (GO:0006188)2.43600311
126mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.43040175
127lipopolysaccharide biosynthetic process (GO:0009103)2.42601721
128ribosomal small subunit biogenesis (GO:0042274)2.41193373
129mitotic sister chromatid cohesion (GO:0007064)2.41100734
130chromosome organization involved in meiosis (GO:0070192)2.40592256
131seminiferous tubule development (GO:0072520)2.40199409
132cilium morphogenesis (GO:0060271)2.39456055
133regulation of male gonad development (GO:2000018)2.39214615
134ER overload response (GO:0006983)2.38498876
135sister chromatid cohesion (GO:0007062)2.36964030
136protein N-linked glycosylation via asparagine (GO:0018279)2.35402064
137positive regulation of p38MAPK cascade (GO:1900745)2.35275641
138response to unfolded protein (GO:0006986)2.34933857
139peptidyl-asparagine modification (GO:0018196)2.34086282
140smoothened signaling pathway (GO:0007224)2.33205451
141nuclear pore complex assembly (GO:0051292)2.33085460
142male meiosis (GO:0007140)2.32809655
143peptide catabolic process (GO:0043171)2.32404843
144nuclear pore organization (GO:0006999)2.32357063
145peptide hormone processing (GO:0016486)2.32308695
146ribosome biogenesis (GO:0042254)2.32120305
147neuron fate determination (GO:0048664)2.30865888
148regulation of mitochondrial translation (GO:0070129)2.30779975
149histone H2A acetylation (GO:0043968)2.30617382
150microtubule depolymerization (GO:0007019)2.30557761
151meiotic nuclear division (GO:0007126)2.30373786
152pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.29675610
153translation (GO:0006412)2.29374117
154protein localization to kinetochore (GO:0034501)2.28460963
155recombinational repair (GO:0000725)2.27887892
156negative regulation of neurological system process (GO:0031645)2.27611577
157negative regulation of oligodendrocyte differentiation (GO:0048715)2.27555096
158decidualization (GO:0046697)2.27482448
159nuclear-transcribed mRNA catabolic process (GO:0000956)2.26740870
160cornea development in camera-type eye (GO:0061303)2.26612238
161L-methionine biosynthetic process (GO:0071265)2.26449950
162response to topologically incorrect protein (GO:0035966)2.26380764
163mitotic nuclear envelope disassembly (GO:0007077)2.26005641
164ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.25928327
165ribonucleoprotein complex biogenesis (GO:0022613)2.25033982
166glandular epithelial cell development (GO:0002068)2.24858835
167regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.24511261
168definitive hemopoiesis (GO:0060216)2.24360772
169cellular protein complex disassembly (GO:0043624)2.21877533
170positive regulation of receptor biosynthetic process (GO:0010870)2.21409092
171chaperone mediated protein folding requiring cofactor (GO:0051085)2.21105967
172negative regulation of RNA splicing (GO:0033119)2.20323334
173glandular epithelial cell differentiation (GO:0002067)2.20127249
174nuclear envelope disassembly (GO:0051081)2.18939333
175membrane disassembly (GO:0030397)2.18939333
176L-alpha-amino acid transmembrane transport (GO:1902475)2.18476154
177mRNA catabolic process (GO:0006402)2.18174158
178regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.17988256
179regulation of vitamin D biosynthetic process (GO:0060556)2.15249343
180nucleotide-sugar metabolic process (GO:0009225)2.14711698
181surfactant homeostasis (GO:0043129)2.13317055
182protein N-linked glycosylation (GO:0006487)2.12802379
183proline biosynthetic process (GO:0006561)2.12767423
184RNA catabolic process (GO:0006401)2.12621079
185ribosomal large subunit biogenesis (GO:0042273)2.12307839
186positive regulation of hormone biosynthetic process (GO:0046886)2.11785257
187embryonic process involved in female pregnancy (GO:0060136)2.11352255
188regulation of interleukin-12 biosynthetic process (GO:0045075)2.09229474
189histone mRNA catabolic process (GO:0071044)2.09120584
190columnar/cuboidal epithelial cell development (GO:0002066)2.08587170
191endocrine pancreas development (GO:0031018)2.07615912

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.36822010
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.96209295
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.56282048
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.24943650
5GATA1_22025678_ChIP-Seq_K562_Human2.95713702
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.94942592
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.91197650
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.88615206
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.84697818
10MYC_22102868_ChIP-Seq_BL_Human2.45550704
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.34871630
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.32318009
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.19776400
14NOTCH1_21737748_ChIP-Seq_TLL_Human2.16189693
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.11149098
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.09239932
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.06959278
18TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.05550518
19NELFA_20434984_ChIP-Seq_ESCs_Mouse1.99973898
20TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.99502686
21SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.94991988
22PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93420292
23* EWS_26573619_Chip-Seq_HEK293_Human1.89254491
24DCP1A_22483619_ChIP-Seq_HELA_Human1.89151719
25* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.85985293
26MYC_18358816_ChIP-ChIP_MESCs_Mouse1.85867266
27CREB1_15753290_ChIP-ChIP_HEK293T_Human1.84303653
28VDR_23849224_ChIP-Seq_CD4+_Human1.84062487
29TRIM28_21343339_ChIP-Seq_HEK293_Human1.83878800
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.82892949
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.82165463
32ZNF274_21170338_ChIP-Seq_K562_Hela1.81611752
33KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.81193951
34ELK1_19687146_ChIP-ChIP_HELA_Human1.79881092
35IRF1_19129219_ChIP-ChIP_H3396_Human1.79580820
36XRN2_22483619_ChIP-Seq_HELA_Human1.77180159
37IGF1R_20145208_ChIP-Seq_DFB_Human1.77128293
38MYC_18940864_ChIP-ChIP_HL60_Human1.76761816
39FUS_26573619_Chip-Seq_HEK293_Human1.76472663
40IRF8_22096565_ChIP-ChIP_GC-B_Human1.73268607
41FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.72758389
42ETS1_20019798_ChIP-Seq_JURKAT_Human1.71366196
43STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.70766679
44SALL1_21062744_ChIP-ChIP_HESCs_Human1.70346922
45ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.69952357
46EST1_17652178_ChIP-ChIP_JURKAT_Human1.67035845
47POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65815025
48SRF_21415370_ChIP-Seq_HL-1_Mouse1.65525156
49DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.65109030
50JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.65075026
51E2F1_18555785_ChIP-Seq_MESCs_Mouse1.63175204
52SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.61328493
53GABP_19822575_ChIP-Seq_HepG2_Human1.59676646
54E2F1_21310950_ChIP-Seq_MCF-7_Human1.59502506
55TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.58888141
56HIF1A_21447827_ChIP-Seq_MCF-7_Human1.58435874
57CLOCK_20551151_ChIP-Seq_293T_Human1.57309333
58RBPJ_22232070_ChIP-Seq_NCS_Mouse1.56824087
59TFEB_21752829_ChIP-Seq_HELA_Human1.54641547
60FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.50524579
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.50214499
62PADI4_21655091_ChIP-ChIP_MCF-7_Human1.49525516
63E2F4_17652178_ChIP-ChIP_JURKAT_Human1.48828498
64ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.45463409
65RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.41501425
66FOXM1_23109430_ChIP-Seq_U2OS_Human1.41294825
67* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.40536940
68STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.40161138
69THAP11_20581084_ChIP-Seq_MESCs_Mouse1.37236790
70MYB_21317192_ChIP-Seq_ERMYB_Mouse1.37170219
71ELK1_22589737_ChIP-Seq_MCF10A_Human1.37001858
72HOXB4_20404135_ChIP-ChIP_EML_Mouse1.35938714
73TTF2_22483619_ChIP-Seq_HELA_Human1.34743906
74AR_21909140_ChIP-Seq_LNCAP_Human1.34742556
75VDR_22108803_ChIP-Seq_LS180_Human1.34293241
76POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.34170543
77HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.33597059
78SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.32316856
79CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.31655316
80ESR1_21235772_ChIP-Seq_MCF-7_Human1.30396526
81FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.29737545
82SCL_19346495_ChIP-Seq_HPC-7_Human1.28089962
83POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.25092848
84* ATF3_27146783_Chip-Seq_COLON_Human1.24921115
85POU5F1_16153702_ChIP-ChIP_HESCs_Human1.23952758
86MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.23613196
87GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.22316793
88CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.21720674
89FOXP3_21729870_ChIP-Seq_TREG_Human1.21460658
90YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21017404
91HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.20157911
92MYB_26560356_Chip-Seq_TH2_Human1.20121005
93CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.19522164
94E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19179416
95PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.18837451
96DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.18579656
97ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.18335270
98FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.17816298
99CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.17791114
100CBX2_27304074_Chip-Seq_ESCs_Mouse1.16489051
101* CHD1_26751641_Chip-Seq_LNCaP_Human1.15494618
102RNF2_27304074_Chip-Seq_NSC_Mouse1.14957107
103HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.14723378
104MYB_26560356_Chip-Seq_TH1_Human1.14226031
105TCF7_22412390_ChIP-Seq_EML_Mouse1.13813508
106RARG_19884340_ChIP-ChIP_MEFs_Mouse1.13153982
107HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.11828927
108STAT3_1855785_ChIP-Seq_MESCs_Mouse1.11744983
109KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10941172
110ZFP57_27257070_Chip-Seq_ESCs_Mouse1.10798106
111MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.10720061
112MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10262389
113CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.09915052
114IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.08968246
115NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.08522160
116SPI1_23547873_ChIP-Seq_NB4_Human1.08351674
117KDM5A_27292631_Chip-Seq_BREAST_Human1.08022450
118PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.07565808
119STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.05907090
120VDR_21846776_ChIP-Seq_THP-1_Human1.05488577
121P300_19829295_ChIP-Seq_ESCs_Human1.04851656
122CIITA_25753668_ChIP-Seq_RAJI_Human1.04345488
123CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.04201917
124TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04094690
125SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.02856204
126TP53_22573176_ChIP-Seq_HFKS_Human1.02838608
127TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02774606
128RUNX1_22412390_ChIP-Seq_EML_Mouse1.02581942
129* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01757772
130CTBP2_25329375_ChIP-Seq_LNCAP_Human1.01336184
131SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00929250
132NCOR1_26117541_ChIP-Seq_K562_Human1.00911727
133TP63_19390658_ChIP-ChIP_HaCaT_Human1.00899848
134KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.00540755
135MAF_26560356_Chip-Seq_TH1_Human0.99083120
136CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.98798914
137TAF15_26573619_Chip-Seq_HEK293_Human0.98735655
138* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.98425297
139NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.97216612
140SOX2_16153702_ChIP-ChIP_HESCs_Human0.93029386
141BMI1_23680149_ChIP-Seq_NPCS_Mouse0.90687016
142* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87888665
143TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.87725139
144NANOG_16153702_ChIP-ChIP_HESCs_Human0.87315186
145* NANOG_18555785_ChIP-Seq_MESCs_Mouse0.86307452
146REST_19997604_ChIP-ChIP_NEURONS_Mouse0.84377399
147NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.84115385
148EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.80879125
149CTBP1_25329375_ChIP-Seq_LNCAP_Human0.80795258
150MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.80710737
151SOX17_20123909_ChIP-Seq_XEN_Mouse0.80238489
152EZH2_27294783_Chip-Seq_NPCs_Mouse0.79436782

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog3.61078270
2MP0003136_yellow_coat_color3.59868371
3MP0006054_spinal_hemorrhage3.14094238
4MP0010352_gastrointestinal_tract_polyps2.87613286
5MP0002938_white_spotting2.80181932
6MP0002102_abnormal_ear_morphology2.71158898
7MP0000013_abnormal_adipose_tissue2.61044225
8MP0008789_abnormal_olfactory_epithelium2.47623898
9MP0003693_abnormal_embryo_hatching2.33710921
10MP0003183_abnormal_peptide_metabolism2.31476587
11MP0006072_abnormal_retinal_apoptosis2.30199937
12MP0000372_irregular_coat_pigmentation2.21919635
13MP0003300_gastrointestinal_ulcer2.16367167
14MP0002095_abnormal_skin_pigmentation2.12428915
15MP0009379_abnormal_foot_pigmentation2.09536958
16MP0002163_abnormal_gland_morphology2.08306137
17MP0005220_abnormal_exocrine_pancreas2.03332368
18MP0002638_abnormal_pupillary_reflex2.02760045
19MP0008007_abnormal_cellular_replicative2.01934797
20MP0008932_abnormal_embryonic_tissue1.94953989
21MP0004957_abnormal_blastocyst_morpholog1.93063477
22MP0000647_abnormal_sebaceous_gland1.86818657
23MP0006292_abnormal_olfactory_placode1.86718832
24MP0005394_taste/olfaction_phenotype1.78460031
25MP0005499_abnormal_olfactory_system1.78460031
26MP0001944_abnormal_pancreas_morphology1.73980057
27MP0003123_paternal_imprinting1.72945658
28MP0003283_abnormal_digestive_organ1.71371583
29MP0004808_abnormal_hematopoietic_stem1.67801284
30MP0005076_abnormal_cell_differentiation1.67623636
31MP0001529_abnormal_vocalization1.66306095
32MP0005187_abnormal_penis_morphology1.65792753
33MP0003566_abnormal_cell_adhesion1.65739940
34MP0004133_heterotaxia1.63300035
35MP0001293_anophthalmia1.62815508
36MP0003937_abnormal_limbs/digits/tail_de1.62674078
37MP0004264_abnormal_extraembryonic_tissu1.61526101
38MP0002693_abnormal_pancreas_physiology1.59301607
39MP0002933_joint_inflammation1.56488756
40MP0000566_synostosis1.55866959
41MP0002210_abnormal_sex_determination1.55325653
42MP0005174_abnormal_tail_pigmentation1.54872659
43MP0000003_abnormal_adipose_tissue1.52838216
44MP0004782_abnormal_surfactant_physiolog1.50716202
45MP0002233_abnormal_nose_morphology1.50691198
46MP0005253_abnormal_eye_physiology1.50078223
47MP0000015_abnormal_ear_pigmentation1.47284575
48MP0003122_maternal_imprinting1.46275066
49MP0000678_abnormal_parathyroid_gland1.45086477
50MP0002138_abnormal_hepatobiliary_system1.44854460
51MP0003077_abnormal_cell_cycle1.43229845
52MP0002160_abnormal_reproductive_system1.43073192
53MP0009053_abnormal_anal_canal1.43064870
54MP0003186_abnormal_redox_activity1.41188511
55MP0000516_abnormal_urinary_system1.39450354
56MP0005367_renal/urinary_system_phenotyp1.39450354
57MP0001324_abnormal_eye_pigmentation1.39065500
58MP0000685_abnormal_immune_system1.38628911
59MP0001545_abnormal_hematopoietic_system1.35924671
60MP0005397_hematopoietic_system_phenotyp1.35924671
61MP0003763_abnormal_thymus_physiology1.35483990
62MP0002653_abnormal_ependyma_morphology1.35239956
63MP0003195_calcinosis1.34299266
64MP0005023_abnormal_wound_healing1.33341645
65MP0005171_absent_coat_pigmentation1.32936714
66MP0003786_premature_aging1.32325468
67MP0000049_abnormal_middle_ear1.30298394
68MP0001958_emphysema1.30071565
69MP0009697_abnormal_copulation1.29486218
70MP0005248_abnormal_Harderian_gland1.28548854
71MP0000490_abnormal_crypts_of1.28521577
72MP0010094_abnormal_chromosome_stability1.25248760
73MP0002896_abnormal_bone_mineralization1.24070717
74MP0001984_abnormal_olfaction1.23561447
75MP0003943_abnormal_hepatobiliary_system1.23449894
76MP0001929_abnormal_gametogenesis1.22589454
77MP0000653_abnormal_sex_gland1.21452034
78MP0003755_abnormal_palate_morphology1.21075077
79MP0001145_abnormal_male_reproductive1.20586146
80MP0005391_vision/eye_phenotype1.19758866
81MP0002697_abnormal_eye_size1.19162630
82MP0002234_abnormal_pharynx_morphology1.18386727
83MP0003795_abnormal_bone_structure1.18112190
84MP0002837_dystrophic_cardiac_calcinosis1.16832592
85MP0003705_abnormal_hypodermis_morpholog1.16588151
86MP0001188_hyperpigmentation1.16465868
87MP0003436_decreased_susceptibility_to1.15359370
88MP0001286_abnormal_eye_development1.14851511
89MP0005257_abnormal_intraocular_pressure1.14529244
90MP0009046_muscle_twitch1.13805412
91MP0008877_abnormal_DNA_methylation1.12614196
92MP0000631_abnormal_neuroendocrine_gland1.12429116
93MP0002177_abnormal_outer_ear1.11060006
94MP0002396_abnormal_hematopoietic_system1.10782868
95MP0009333_abnormal_splenocyte_physiolog1.10520880
96MP0002009_preneoplasia1.09375483
97MP0002928_abnormal_bile_duct1.09088897
98MP0005389_reproductive_system_phenotype1.07835713
99MP0002282_abnormal_trachea_morphology1.07793540
100MP0002405_respiratory_system_inflammati1.07302772
101MP0000350_abnormal_cell_proliferation1.07086778
102MP0004885_abnormal_endolymph1.06778570
103MP0003567_abnormal_fetal_cardiomyocyte1.06377635
104MP0010307_abnormal_tumor_latency1.06131679
105MP0002166_altered_tumor_susceptibility1.06083516
106MP0004947_skin_inflammation1.04963188
107MP0000858_altered_metastatic_potential1.04481981
108MP0002909_abnormal_adrenal_gland1.03375028
109MP0001119_abnormal_female_reproductive1.03332952
110MP0008057_abnormal_DNA_replication1.03170157
111MP0003724_increased_susceptibility_to1.02663530
112MP0000778_abnormal_nervous_system1.02421409
113MP0003011_delayed_dark_adaptation1.02128932
114MP0005408_hypopigmentation1.01460837
115MP0003111_abnormal_nucleus_morphology1.00873744
116MP0000026_abnormal_inner_ear0.99968574
117MP0008058_abnormal_DNA_repair0.99265180
118MP0005275_abnormal_skin_tensile0.96329885
119MP0001881_abnormal_mammary_gland0.96135605
120MP0010030_abnormal_orbit_morphology0.95993963
121MP0004197_abnormal_fetal_growth/weight/0.95366360
122MP0008995_early_reproductive_senescence0.95089145
123MP0004272_abnormal_basement_membrane0.95074629
124MP0000465_gastrointestinal_hemorrhage0.94463314
125MP0000163_abnormal_cartilage_morphology0.94178318
126MP0001533_abnormal_skeleton_physiology0.93610611
127MP0001764_abnormal_homeostasis0.92768704
128MP0001542_abnormal_bone_strength0.92627537
129MP0002086_abnormal_extraembryonic_tissu0.92034512
130MP0005503_abnormal_tendon_morphology0.91440753
131MP0002092_abnormal_eye_morphology0.90668484
132MP0001730_embryonic_growth_arrest0.90401703
133MP0008961_abnormal_basal_metabolism0.90247834
134MP0005379_endocrine/exocrine_gland_phen0.89052458
135MP0005084_abnormal_gallbladder_morpholo0.89041876
136MP0005195_abnormal_posterior_eye0.88866139
137MP0000383_abnormal_hair_follicle0.88144236
138MP0002060_abnormal_skin_morphology0.88031224
139MP0008438_abnormal_cutaneous_collagen0.87794445
140* MP0002113_abnormal_skeleton_development0.87683649
141MP0005508_abnormal_skeleton_morphology0.87020492
142MP0005390_skeleton_phenotype0.86521783
143* MP0002019_abnormal_tumor_incidence0.85704802
144MP0002398_abnormal_bone_marrow0.85211917
145MP0005623_abnormal_meninges_morphology0.85208470
146MP0000613_abnormal_salivary_gland0.84197970
147MP0002089_abnormal_postnatal_growth/wei0.83525707
148MP0003448_altered_tumor_morphology0.83491857
149MP0002075_abnormal_coat/hair_pigmentati0.83419281
150MP0002751_abnormal_autonomic_nervous0.82915348
151MP0001697_abnormal_embryo_size0.82715249
152MP0005197_abnormal_uvea_morphology0.82687573
153MP0010234_abnormal_vibrissa_follicle0.82338371
154MP0001186_pigmentation_phenotype0.82264557
155MP0000703_abnormal_thymus_morphology0.81510556
156MP0005551_abnormal_eye_electrophysiolog0.81228719
157MP0010386_abnormal_urinary_bladder0.80981992
158MP0002084_abnormal_developmental_patter0.80144083
159MP0003698_abnormal_male_reproductive0.79965708
160MP0002090_abnormal_vision0.79395763
161MP0003942_abnormal_urinary_system0.79308799
162MP0001853_heart_inflammation0.79219357
163MP0010678_abnormal_skin_adnexa0.79212481
164MP0001502_abnormal_circadian_rhythm0.79018157
165MP0006276_abnormal_autonomic_nervous0.78821573
166MP0010155_abnormal_intestine_physiology0.77671928
167MP0010368_abnormal_lymphatic_system0.77066756
168MP0003121_genomic_imprinting0.76864765
169MP0002098_abnormal_vibrissa_morphology0.76413559
170MP0001835_abnormal_antigen_presentation0.76306337
171MP0003279_aneurysm0.76135508
172MP0001845_abnormal_inflammatory_respons0.76116481
173MP0003959_abnormal_lean_body0.76044416
174MP0005671_abnormal_response_to0.75731088
175MP0002006_tumorigenesis0.75423178
176MP0003984_embryonic_growth_retardation0.75245551
177MP0002088_abnormal_embryonic_growth/wei0.74747082
178MP0002998_abnormal_bone_remodeling0.74611995
179MP0009384_cardiac_valve_regurgitation0.73978873
180MP0002080_prenatal_lethality0.73912774

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)4.38418660
2Cervical subluxation (HP:0003308)3.79938603
3Irregular epiphyses (HP:0010582)3.66742775
411 pairs of ribs (HP:0000878)3.35571729
5Pancreatic fibrosis (HP:0100732)3.30631347
6True hermaphroditism (HP:0010459)3.24017208
7Flat capital femoral epiphysis (HP:0003370)3.15311752
8Thoracolumbar scoliosis (HP:0002944)3.09158469
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.06879873
10Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.05886666
11Abnormality of midbrain morphology (HP:0002418)2.93984437
12Molar tooth sign on MRI (HP:0002419)2.93984437
13Pancreatic cysts (HP:0001737)2.92444209
14Acute necrotizing encephalopathy (HP:0006965)2.87817437
15Beaking of vertebral bodies (HP:0004568)2.87188094
16Medial flaring of the eyebrow (HP:0010747)2.81956053
17Abnormality of cells of the erythroid lineage (HP:0012130)2.74249217
18Hypoglycemic seizures (HP:0002173)2.74059429
19Chromsome breakage (HP:0040012)2.72196798
20Abnormal number of erythroid precursors (HP:0012131)2.71576898
21Interstitial pulmonary disease (HP:0006530)2.68089949
22Missing ribs (HP:0000921)2.66864308
23Flat acetabular roof (HP:0003180)2.65692953
24Vitreoretinal degeneration (HP:0000655)2.65384271
25Abnormal foot bone ossification (HP:0010675)2.61371259
26Symptomatic seizures (HP:0011145)2.60808805
27Short tibia (HP:0005736)2.60155566
28Thrombocytosis (HP:0001894)2.59201829
29Postaxial foot polydactyly (HP:0001830)2.59065307
30Congenital primary aphakia (HP:0007707)2.58331221
31Flattened epiphyses (HP:0003071)2.55299004
32Abnormal tarsal ossification (HP:0008369)2.54480911
33Increased hepatocellular lipid droplets (HP:0006565)2.53869796
34Meckel diverticulum (HP:0002245)2.51444888
35Hypoplastic ischia (HP:0003175)2.50667126
36Aplasia/Hypoplasia of the uvula (HP:0010293)2.49387954
37Lipid accumulation in hepatocytes (HP:0006561)2.46776694
38Metaphyseal cupping (HP:0003021)2.45377402
39Abnormal mitochondria in muscle tissue (HP:0008316)2.45209805
40Cupped ribs (HP:0000887)2.45022982
41Joint stiffness (HP:0001387)2.43117858
42Small epiphyses (HP:0010585)2.41737750
43Delayed epiphyseal ossification (HP:0002663)2.41476999
44Nephronophthisis (HP:0000090)2.40193393
45Gait imbalance (HP:0002141)2.40193071
46Mitochondrial inheritance (HP:0001427)2.39472912
47Reticulocytopenia (HP:0001896)2.37406593
48Abnormality of the ileum (HP:0001549)2.35879396
49Acute encephalopathy (HP:0006846)2.35118916
50Progressive macrocephaly (HP:0004481)2.35048473
51Hyperinsulinemic hypoglycemia (HP:0000825)2.35019851
52Increased CSF lactate (HP:0002490)2.34417848
53Nephrogenic diabetes insipidus (HP:0009806)2.34293962
54Adrenal hypoplasia (HP:0000835)2.31038937
55Platyspondyly (HP:0000926)2.27497127
56Aplastic anemia (HP:0001915)2.26831171
57Aplasia/Hypoplasia of the tibia (HP:0005772)2.26749996
58Abnormality of calcium-phosphate metabolism (HP:0100530)2.26559654
59Colon cancer (HP:0003003)2.25959903
60Genu varum (HP:0002970)2.23525594
61Vertebral hypoplasia (HP:0008417)2.23003686
62Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.23003686
63Abnormality of the distal phalanges of the toes (HP:0010182)2.22976037
64Ectopic kidney (HP:0000086)2.21826124
65Aplasia/Hypoplasia of the sacrum (HP:0008517)2.21352210
663-Methylglutaconic aciduria (HP:0003535)2.21184157
67Large for gestational age (HP:0001520)2.20954534
68Protrusio acetabuli (HP:0003179)2.20715319
69Coxa valga (HP:0002673)2.19077177
70Aplasia/Hypoplasia of the fovea (HP:0008060)2.19013522
71Hypoplasia of the fovea (HP:0007750)2.19013522
72Tubular atrophy (HP:0000092)2.17476622
73Anencephaly (HP:0002323)2.16736725
74Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.16706370
75Abnormal protein N-linked glycosylation (HP:0012347)2.16706370
76Abnormal protein glycosylation (HP:0012346)2.16706370
77Abnormal glycosylation (HP:0012345)2.16706370
78Sclerocornea (HP:0000647)2.16282903
79Hyperglycemia (HP:0003074)2.14346537
80Triphalangeal thumb (HP:0001199)2.14320282
81Abnormality of the renal medulla (HP:0100957)2.14180839
82Abnormality of the renal collecting system (HP:0004742)2.13976764
83Median cleft lip (HP:0000161)2.13449905
84Type I transferrin isoform profile (HP:0003642)2.12126276
85Bile duct proliferation (HP:0001408)2.11903706
86Abnormal biliary tract physiology (HP:0012439)2.11903706
87Fibular hypoplasia (HP:0003038)2.09636497
88Poor head control (HP:0002421)2.07209667
89Metaphyseal dysplasia (HP:0100255)2.06086000
90Type II lissencephaly (HP:0007260)2.06034108
91Abnormality of the ischium (HP:0003174)2.05554630
92Abnormality of the metopic suture (HP:0005556)2.04894729
93Hypoplasia of the odontoid process (HP:0003311)2.04526525
94Duplicated collecting system (HP:0000081)2.03988932
95Abnormal number of incisors (HP:0011064)2.03315697
96Aplasia/Hypoplasia of the tongue (HP:0010295)2.02334807
97Severe short stature (HP:0003510)2.02229905
98Glossoptosis (HP:0000162)2.00907371
99Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.00197247
100Abnormality of femoral epiphyses (HP:0006499)2.00197247
101Patchy hypopigmentation of hair (HP:0011365)1.99907496
102Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.99696877
103Abnormality of the renal cortex (HP:0011035)1.99678381
104Disproportionate short-trunk short stature (HP:0003521)1.99439621
105Abnormality of the preputium (HP:0100587)1.99157940
106Microretrognathia (HP:0000308)1.95733064
107Preaxial hand polydactyly (HP:0001177)1.95456663
108Abnormality of chromosome stability (HP:0003220)1.94904759
109Abnormality of the acetabulum (HP:0003170)1.94891441
110Degeneration of anterior horn cells (HP:0002398)1.93521521
111Abnormality of the anterior horn cell (HP:0006802)1.93521521
112Sloping forehead (HP:0000340)1.93247100
113Horseshoe kidney (HP:0000085)1.93040226
114Oligodactyly (HP:0012165)1.91191338
115Carpal bone hypoplasia (HP:0001498)1.90780695
116Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.90474848
117Abnormality of the vertebral endplates (HP:0005106)1.90403450
118Aganglionic megacolon (HP:0002251)1.89081223
119Squamous cell carcinoma (HP:0002860)1.88991482
120Postaxial hand polydactyly (HP:0001162)1.88758896
121Broad face (HP:0000283)1.87866162
122Irregular vertebral endplates (HP:0003301)1.87730352
123Supernumerary spleens (HP:0009799)1.87524545
124Abnormal vertebral ossification (HP:0100569)1.87252282
125Osteoarthritis (HP:0002758)1.86739539
126Hepatic necrosis (HP:0002605)1.86019043
127Small intestinal stenosis (HP:0012848)1.85765462
128Duodenal stenosis (HP:0100867)1.85765462
129Hyperparathyroidism (HP:0000843)1.85687370
130Coxa vara (HP:0002812)1.85645317
131Abnormal pancreas size (HP:0012094)1.85392417
132Genital tract atresia (HP:0001827)1.85106425
133Tubulointerstitial nephritis (HP:0001970)1.84449074
134Holoprosencephaly (HP:0001360)1.84443516
135Oligodactyly (hands) (HP:0001180)1.84169526
136Rectal prolapse (HP:0002035)1.83902037
137Ketoacidosis (HP:0001993)1.83716531
138Cortical dysplasia (HP:0002539)1.83448384
139Rib fusion (HP:0000902)1.83337035
140Neonatal short-limb short stature (HP:0008921)1.83283038
141Intestinal atresia (HP:0011100)1.82762942
142Renal Fanconi syndrome (HP:0001994)1.82708067
143Radial bowing (HP:0002986)1.82324005
144White forelock (HP:0002211)1.82126148
145Abnormality of the calcaneus (HP:0008364)1.82071944
146Vertebral compression fractures (HP:0002953)1.81610097
147Aplasia/hypoplasia of the uterus (HP:0008684)1.81591734
148Broad distal phalanx of finger (HP:0009836)1.81334710
149Abnormality of the duodenum (HP:0002246)1.80860653
150Short middle phalanx of the 5th finger (HP:0004220)1.80792538
151Hyperglycinemia (HP:0002154)1.80210351
152Abnormality of the epiphysis of the femoral head (HP:0010574)1.79933830
153Abnormality of the femoral head (HP:0003368)1.79880201
154Spinal muscular atrophy (HP:0007269)1.79712812
155Prominent metopic ridge (HP:0005487)1.78987704
156Abnormality of endocrine pancreas physiology (HP:0012093)1.78970827
157Abnormality of the pancreatic islet cells (HP:0006476)1.78970827
158Abdominal distention (HP:0003270)1.78849154
159Metaphyseal irregularity (HP:0003025)1.78226647
160Cerebral edema (HP:0002181)1.77718984
161Abnormality of the intrinsic pathway (HP:0010989)1.77420264
162Ulnar deviation of the wrist (HP:0003049)1.76028841
163Occipital encephalocele (HP:0002085)1.75920123
164Protuberant abdomen (HP:0001538)1.75580046
165Cutaneous melanoma (HP:0012056)1.75162265
166Absent thumb (HP:0009777)1.74490737
167Vaginal atresia (HP:0000148)1.74258972
168Congenital hepatic fibrosis (HP:0002612)1.73964610
169Spinal cord compression (HP:0002176)1.73808887
170Abnormality of the odontoid process (HP:0003310)1.73505028
171Congenital stationary night blindness (HP:0007642)1.73139726
172Anophthalmia (HP:0000528)1.72816984
173Abnormal lung lobation (HP:0002101)1.72700110
174Spondylolisthesis (HP:0003302)1.72207966
175Insulin resistance (HP:0000855)1.72198161
176Aplasia/Hypoplasia of the fibula (HP:0006492)1.71818616
177Male pseudohermaphroditism (HP:0000037)1.71161419
178Abnormal biliary tract morphology (HP:0012440)1.69268077
179Broad palm (HP:0001169)1.66759638
180Insulin-resistant diabetes mellitus (HP:0000831)1.66136947
181Patent foramen ovale (HP:0001655)1.65531087
182Reduced antithrombin III activity (HP:0001976)1.65221721
183Decreased skull ossification (HP:0004331)1.64472776
184Hypoglycemic coma (HP:0001325)1.63774850
185Abnormality of the fovea (HP:0000493)1.63073687
186Abnormality of the wing of the ilium (HP:0011867)1.61760946
187Pallor (HP:0000980)1.60690526
188Micronodular cirrhosis (HP:0001413)1.59245329
189Thickened calvaria (HP:0002684)1.58850985

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK153.84956490
2PNCK3.28005390
3PASK2.68295452
4PIK3CG2.45611865
5BMPR1B2.39806520
6EPHA22.35053709
7RPS6KA42.34365578
8MAP3K32.26775394
9DYRK32.17340758
10PIM22.16622100
11WNK32.11070037
12BRSK22.08823386
13ERN12.02125814
14NME22.01223887
15TRIB31.96261980
16FLT31.92230300
17BCR1.84789838
18NEK11.84699637
19BCKDK1.80131349
20ADRBK21.77590914
21TGFBR11.77572230
22PLK41.76246939
23NLK1.74808367
24PLK31.73783455
25WNK41.71852294
26ZAP701.71723529
27SRPK11.70371764
28RPS6KB21.68240854
29FRK1.62277231
30STK161.59421817
31EIF2AK31.56427339
32SCYL21.51883015
33STK391.50364805
34EPHB21.50322138
35WEE11.44167984
36TTK1.42495340
37GRK11.41487777
38ACVR1B1.38293561
39DYRK21.36479625
40HIPK21.35573180
41JAK31.35560331
42NUAK11.33408512
43TAOK31.33325338
44TRIM281.32647611
45PRKG21.32473478
46CDC71.32168816
47MAPKAPK31.30713917
48LATS11.29974614
49LRRK21.29262675
50PLK21.25592201
51TGFBR21.24894943
52TESK11.22479680
53TEC1.20718617
54STK241.20662426
55STK101.18764520
56MAP2K31.18491132
57CSNK1G31.16584455
58IRAK11.13696800
59MAP3K21.11475078
60CSNK1G11.08487494
61EPHA31.08454206
62MST41.07539611
63PDK21.07120662
64MAP4K21.07064527
65CSNK1G21.06358483
66NEK21.06293392
67CHEK21.04396066
68CDK121.04133206
69PRKD31.03974393
70CCNB11.03034826
71IRAK31.01029544
72BRD41.00949806
73VRK10.99518444
74VRK20.98920020
75NEK90.97569792
76INSRR0.97499510
77CHUK0.97198321
78PAK40.96194396
79MOS0.92834086
80TXK0.92454080
81MAP2K20.91369652
82PTK60.89996691
83BRSK10.89512641
84MKNK10.88944263
85CDK70.87425807
86AURKB0.87234192
87PIM10.86412605
88MKNK20.85512170
89CSNK1A1L0.85179635
90TSSK60.84866505
91SIK30.83543395
92MARK30.81716398
93PKN20.81570473
94ERBB30.79821432
95MAP3K100.79738132
96MET0.78538548
97EIF2AK20.77717431
98RPS6KA50.77611836
99BTK0.75837868
100DDR20.75386414
101CASK0.73348002
102PTK20.72531161
103MAP4K10.70584461
104AURKA0.69595205
105EEF2K0.69512678
106STK38L0.68318400
107LIMK10.67207853
108RAF10.67152605
109IKBKB0.67019292
110BUB10.65685060
111PDGFRA0.65577305
112ITK0.64095692
113CDK30.63908491
114MAP3K40.63637330
115ATR0.60128073
116MAP3K80.59783295
117CHEK10.59376812
118MTOR0.58333734
119ABL20.58304830
120EIF2AK10.57973537
121RIPK10.57941075
122DYRK1B0.57748008
123ATM0.57328727
124PBK0.56915338
125CDK60.56616433
126MAPKAPK20.55712857
127TBK10.54931471
128PAK20.54825882
129MAP3K10.54231763
130CDK40.53926256
131GSK3A0.53911669
132CDK80.53565644
133FGFR30.52789814
134STK30.52023890
135CSNK2A10.51409896
136MAP2K70.50070403
137GRK70.49980254
138ERBB40.49383595
139KDR0.48670352
140PRKCG0.46141486
141TIE10.45177991
142MAP3K140.44896536
143FER0.44430432
144PRKD20.43508693
145TLK10.43292550
146CDK190.42991934
147ILK0.42884672
148CDK140.42512658
149ZAK0.40844329
150CDK90.39498607
151YES10.39134922
152PLK10.36947606
153TAF10.36672813
154RPS6KA10.36441941
155FGFR40.36326518
156DAPK30.35499478
157PRKCE0.34534312
158CDK11A0.32461881
159UHMK10.32308392
160CSNK2A20.29349257
161NME10.29282447
162NTRK30.28025583

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.84253230
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.25029352
3Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.66405190
4Oxidative phosphorylation_Homo sapiens_hsa001902.51825814
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.41716651
6Ribosome_Homo sapiens_hsa030102.32822624
7DNA replication_Homo sapiens_hsa030302.22326283
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.11478041
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.03798140
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.02714252
11Parkinsons disease_Homo sapiens_hsa050121.98437349
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.94194894
13N-Glycan biosynthesis_Homo sapiens_hsa005101.82310909
14Steroid biosynthesis_Homo sapiens_hsa001001.81700734
15RNA transport_Homo sapiens_hsa030131.79704088
16Fatty acid elongation_Homo sapiens_hsa000621.76141998
17Antigen processing and presentation_Homo sapiens_hsa046121.74364872
18Thyroid cancer_Homo sapiens_hsa052161.71516712
19Spliceosome_Homo sapiens_hsa030401.68523296
20Mismatch repair_Homo sapiens_hsa034301.66046821
21Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.59635417
22Cell cycle_Homo sapiens_hsa041101.58585005
23Huntingtons disease_Homo sapiens_hsa050161.58399535
24p53 signaling pathway_Homo sapiens_hsa041151.57603518
25Type I diabetes mellitus_Homo sapiens_hsa049401.48924860
26Base excision repair_Homo sapiens_hsa034101.46084391
27RNA polymerase_Homo sapiens_hsa030201.43146954
28Nucleotide excision repair_Homo sapiens_hsa034201.42297193
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.41941604
30Legionellosis_Homo sapiens_hsa051341.36692282
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.35503057
32Pyrimidine metabolism_Homo sapiens_hsa002401.32692085
33Bladder cancer_Homo sapiens_hsa052191.28375876
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.25538857
35ECM-receptor interaction_Homo sapiens_hsa045121.23210937
36Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.23081905
37Glutathione metabolism_Homo sapiens_hsa004801.20068066
38Transcriptional misregulation in cancer_Homo sapiens_hsa052021.16685675
39Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.16068087
40Basal cell carcinoma_Homo sapiens_hsa052171.15028493
41Herpes simplex infection_Homo sapiens_hsa051681.14214021
42HTLV-I infection_Homo sapiens_hsa051661.13621265
43Alzheimers disease_Homo sapiens_hsa050101.11349837
44Phototransduction_Homo sapiens_hsa047441.10973597
45* RNA degradation_Homo sapiens_hsa030181.10689006
46Folate biosynthesis_Homo sapiens_hsa007901.10382251
47Small cell lung cancer_Homo sapiens_hsa052221.10288897
48NF-kappa B signaling pathway_Homo sapiens_hsa040641.09690715
49Propanoate metabolism_Homo sapiens_hsa006401.09644432
50Other glycan degradation_Homo sapiens_hsa005111.08380207
51TNF signaling pathway_Homo sapiens_hsa046681.05635995
52One carbon pool by folate_Homo sapiens_hsa006701.05204589
53Glycosaminoglycan degradation_Homo sapiens_hsa005311.04843238
54Proteasome_Homo sapiens_hsa030501.04449973
55Hedgehog signaling pathway_Homo sapiens_hsa043401.03694693
56Basal transcription factors_Homo sapiens_hsa030221.02926305
57Selenocompound metabolism_Homo sapiens_hsa004501.02018253
58Apoptosis_Homo sapiens_hsa042101.01440423
59Leishmaniasis_Homo sapiens_hsa051401.00745879
60Viral carcinogenesis_Homo sapiens_hsa052031.00363679
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.00088619
62Collecting duct acid secretion_Homo sapiens_hsa049660.99733112
63Regulation of autophagy_Homo sapiens_hsa041400.97296093
64Protein digestion and absorption_Homo sapiens_hsa049740.97252207
65Hematopoietic cell lineage_Homo sapiens_hsa046400.96871411
66Measles_Homo sapiens_hsa051620.96721131
67Acute myeloid leukemia_Homo sapiens_hsa052210.96516728
68mRNA surveillance pathway_Homo sapiens_hsa030150.95913198
69Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.95874698
70Butanoate metabolism_Homo sapiens_hsa006500.95211944
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.93665400
72Homologous recombination_Homo sapiens_hsa034400.91267461
73Vitamin B6 metabolism_Homo sapiens_hsa007500.91009724
74TGF-beta signaling pathway_Homo sapiens_hsa043500.89387061
75Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.86151603
76Jak-STAT signaling pathway_Homo sapiens_hsa046300.85596620
77Chronic myeloid leukemia_Homo sapiens_hsa052200.84893400
78Hepatitis B_Homo sapiens_hsa051610.84372344
79Peroxisome_Homo sapiens_hsa041460.81822343
80Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.81722174
81Prolactin signaling pathway_Homo sapiens_hsa049170.80482931
82Toxoplasmosis_Homo sapiens_hsa051450.79821038
83Epstein-Barr virus infection_Homo sapiens_hsa051690.79454390
84Focal adhesion_Homo sapiens_hsa045100.77501438
85Shigellosis_Homo sapiens_hsa051310.76734557
86AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76536313
87Lysosome_Homo sapiens_hsa041420.76282068
88Vibrio cholerae infection_Homo sapiens_hsa051100.75650917
89Sphingolipid metabolism_Homo sapiens_hsa006000.75613370
90Caffeine metabolism_Homo sapiens_hsa002320.73600455
91Circadian rhythm_Homo sapiens_hsa047100.73035880
92Non-homologous end-joining_Homo sapiens_hsa034500.70137179
93Allograft rejection_Homo sapiens_hsa053300.68842498
94MicroRNAs in cancer_Homo sapiens_hsa052060.68169224
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67896006
96Metabolic pathways_Homo sapiens_hsa011000.67658486
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67522596
98Malaria_Homo sapiens_hsa051440.67119088
99Adherens junction_Homo sapiens_hsa045200.66006559
100NOD-like receptor signaling pathway_Homo sapiens_hsa046210.63931029
101Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63902837
102Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63784754
103Proteoglycans in cancer_Homo sapiens_hsa052050.63772623
104Pyruvate metabolism_Homo sapiens_hsa006200.62602869
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62324084
106PI3K-Akt signaling pathway_Homo sapiens_hsa041510.62191869
107Hippo signaling pathway_Homo sapiens_hsa043900.61924232
108Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.61918706
109Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61725903
110Prostate cancer_Homo sapiens_hsa052150.61522155
111Osteoclast differentiation_Homo sapiens_hsa043800.58907095
112Nitrogen metabolism_Homo sapiens_hsa009100.58411756
113Influenza A_Homo sapiens_hsa051640.58342280
114Oocyte meiosis_Homo sapiens_hsa041140.58261703
115Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.58186189
116Sulfur metabolism_Homo sapiens_hsa009200.57962352
117Fatty acid metabolism_Homo sapiens_hsa012120.57541535
118T cell receptor signaling pathway_Homo sapiens_hsa046600.55937599
119Purine metabolism_Homo sapiens_hsa002300.55173174
120Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54428103
121Colorectal cancer_Homo sapiens_hsa052100.54116137
122Rheumatoid arthritis_Homo sapiens_hsa053230.52790643
123Galactose metabolism_Homo sapiens_hsa000520.52319782
124Amoebiasis_Homo sapiens_hsa051460.50891891
125RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.50072229
126Intestinal immune network for IgA production_Homo sapiens_hsa046720.49312333
127Asthma_Homo sapiens_hsa053100.49137541
128SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48073818
129Leukocyte transendothelial migration_Homo sapiens_hsa046700.47107367
130Primary immunodeficiency_Homo sapiens_hsa053400.46850443
131Arginine and proline metabolism_Homo sapiens_hsa003300.46715043
132Neurotrophin signaling pathway_Homo sapiens_hsa047220.46440044
133Fanconi anemia pathway_Homo sapiens_hsa034600.46060466
134Pertussis_Homo sapiens_hsa051330.45606227
135Sulfur relay system_Homo sapiens_hsa041220.45534475
136Tryptophan metabolism_Homo sapiens_hsa003800.44396576
137Pathways in cancer_Homo sapiens_hsa052000.44149434
138FoxO signaling pathway_Homo sapiens_hsa040680.43731245
139Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43414173
140Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40567740
141Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38033640
142Carbon metabolism_Homo sapiens_hsa012000.35055287
143Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34417881
144Biosynthesis of amino acids_Homo sapiens_hsa012300.33354243
145Ether lipid metabolism_Homo sapiens_hsa005650.32019039
146Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31119860
147Primary bile acid biosynthesis_Homo sapiens_hsa001200.29150054
148Alcoholism_Homo sapiens_hsa050340.25381737
149Mineral absorption_Homo sapiens_hsa049780.24339231
150alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23882517
151Cardiac muscle contraction_Homo sapiens_hsa042600.21904207
152Pentose and glucuronate interconversions_Homo sapiens_hsa000400.19619335
153Prion diseases_Homo sapiens_hsa050200.16544301
154Fatty acid degradation_Homo sapiens_hsa000710.14238938
155Linoleic acid metabolism_Homo sapiens_hsa005910.12982843

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