BTG4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein can induce G1 arrest in the cell cycle. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1retinal cone cell development (GO:0046549)7.14486372
2piRNA metabolic process (GO:0034587)7.01611719
3regulation of meiosis (GO:0040020)6.63970123
4regulation of meiosis I (GO:0060631)6.41230575
5regulation of attachment of spindle microtubules to kinetochore (GO:0051988)6.40440836
6mitotic metaphase plate congression (GO:0007080)6.39950544
7regulation of histone H3-K9 methylation (GO:0051570)6.26533967
8centriole replication (GO:0007099)6.02938627
9negative regulation of hormone biosynthetic process (GO:0032353)6.01875456
10negative regulation of hormone metabolic process (GO:0032351)6.01875456
11regulation of female gonad development (GO:2000194)5.95492767
12regulation of acrosome reaction (GO:0060046)5.93029537
13negative regulation of retinoic acid receptor signaling pathway (GO:0048387)5.90725243
14female gamete generation (GO:0007292)5.88883800
15positive regulation of histone H3-K4 methylation (GO:0051571)5.85810485
16regulation of steroid hormone secretion (GO:2000831)5.81584126
17maturation of 5.8S rRNA (GO:0000460)5.64806528
18negative regulation of meiosis (GO:0045835)5.63044368
19meiotic cell cycle (GO:0051321)5.60023098
20oocyte development (GO:0048599)5.59903283
21synapsis (GO:0007129)5.53224549
22negative regulation of histone methylation (GO:0031061)5.45336478
23positive regulation of gastrulation (GO:2000543)5.43803428
24regulation of exit from mitosis (GO:0007096)5.43043621
25DNA damage induced protein phosphorylation (GO:0006975)5.37373938
26regulation of RIG-I signaling pathway (GO:0039535)5.33719135
27glycine transport (GO:0015816)5.29733423
28regulation of histone H3-K27 methylation (GO:0061085)5.28351741
29oocyte maturation (GO:0001556)5.26178641
30regulation of meiotic cell cycle (GO:0051445)5.23252441
31metaphase plate congression (GO:0051310)5.15656406
32attachment of spindle microtubules to kinetochore (GO:0008608)5.12893895
33male meiosis (GO:0007140)5.12199488
34glycerophospholipid catabolic process (GO:0046475)5.10676069
35multicellular organism reproduction (GO:0032504)5.01628681
36relaxation of smooth muscle (GO:0044557)4.99429147
37mitotic chromosome condensation (GO:0007076)4.98679706
38synaptonemal complex assembly (GO:0007130)4.98530313
39positive regulation of megakaryocyte differentiation (GO:0045654)4.96166781
40regulation of glucocorticoid metabolic process (GO:0031943)4.87557781
41primitive streak formation (GO:0090009)4.86146864
42chromosome organization involved in meiosis (GO:0070192)4.84094102
43negative regulation of reproductive process (GO:2000242)4.78991246
44mitotic sister chromatid segregation (GO:0000070)4.75654625
45histone H2A monoubiquitination (GO:0035518)4.75575619
46establishment of chromosome localization (GO:0051303)4.70861475
47DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla4.65058459
48regulation of retinoic acid receptor signaling pathway (GO:0048385)4.63976550
49negative regulation of cAMP-mediated signaling (GO:0043951)4.58930130
50DNA damage response, signal transduction resulting in transcription (GO:0042772)4.56334123
51meiotic chromosome segregation (GO:0045132)4.52623797
52oogenesis (GO:0048477)4.51009753
53regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)4.50952225
54type B pancreatic cell development (GO:0003323)4.50565706
55nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)4.45763584
56regulation of sister chromatid cohesion (GO:0007063)4.43041950
57synaptonemal complex organization (GO:0070193)4.40190879
58regulation of transforming growth factor beta2 production (GO:0032909)4.33244024
59negative regulation of meiotic cell cycle (GO:0051447)4.20755980
60centriole assembly (GO:0098534)4.19500107
61regulation of spindle organization (GO:0090224)4.13098554
62labyrinthine layer development (GO:0060711)4.12736462
63DNA methylation involved in gamete generation (GO:0043046)4.12399142
64histone H2A ubiquitination (GO:0033522)4.12394135
65positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)4.10964530
66monoubiquitinated protein deubiquitination (GO:0035520)4.07784751
67protein K6-linked ubiquitination (GO:0085020)4.01131185
68regulation of mitotic spindle organization (GO:0060236)3.98012782
69female gonad development (GO:0008585)3.96629915
70regulation of double-strand break repair via homologous recombination (GO:0010569)3.91091078
71negative regulation of smooth muscle cell differentiation (GO:0051151)3.90331748
72somite rostral/caudal axis specification (GO:0032525)3.89920199
73chromosome segregation (GO:0007059)3.89717181
74CENP-A containing nucleosome assembly (GO:0034080)3.89223008
75genitalia morphogenesis (GO:0035112)3.87507229
76positive regulation of DNA-dependent DNA replication (GO:2000105)3.87142607
77positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.86006905
78neuron fate determination (GO:0048664)3.85725386
79sister chromatid segregation (GO:0000819)3.81838483
80pyrimidine-containing compound transmembrane transport (GO:0072531)3.81814765
81L-amino acid import (GO:0043092)3.79653429
82regulation of DNA methylation (GO:0044030)3.78697403
83negative regulation of cardiac muscle hypertrophy (GO:0010614)3.77455915
84positive regulation of histone methylation (GO:0031062)3.77165890
85protein localization to chromosome (GO:0034502)3.76898698
86chromatin remodeling at centromere (GO:0031055)3.75206099
87regulation of mononuclear cell migration (GO:0071675)3.74055334
88regulation of spindle checkpoint (GO:0090231)3.68482663
89positive regulation of chromosome segregation (GO:0051984)3.68166149
90protein localization to kinetochore (GO:0034501)3.67720420
91DNA replication-independent nucleosome organization (GO:0034724)3.66579983
92DNA replication-independent nucleosome assembly (GO:0006336)3.66579983
93regulation of steroid hormone biosynthetic process (GO:0090030)3.65729223
94centrosome duplication (GO:0051298)3.63588778
95regulation of cell maturation (GO:1903429)3.61473157
96negative regulation of alcohol biosynthetic process (GO:1902931)3.61256501
97protein localization to chromosome, centromeric region (GO:0071459)3.60580530
98negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.59030505
99negative regulation of DNA-templated transcription, elongation (GO:0032785)3.59030505
100microtubule severing (GO:0051013)3.57566707
101regulation of chromosome segregation (GO:0051983)3.54310407
102histone exchange (GO:0043486)3.53817885
103protein kinase C signaling (GO:0070528)3.53317899
104parturition (GO:0007567)3.52122058
105translesion synthesis (GO:0019985)3.51863635
106myoblast migration (GO:0051451)3.50123770
107DNA alkylation (GO:0006305)3.49123310
108DNA methylation (GO:0006306)3.49123310
109spindle checkpoint (GO:0031577)3.48709577
110gene silencing by RNA (GO:0031047)3.43854990
111meiosis I (GO:0007127)3.43536844
112gene silencing (GO:0016458)3.42878607
113positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.42841182
114mitotic nuclear envelope disassembly (GO:0007077)3.38853834
115meiotic nuclear division (GO:0007126)3.37439687
116male meiosis I (GO:0007141)3.36837732
117phosphorelay signal transduction system (GO:0000160)3.36151389
118dopamine biosynthetic process (GO:0042416)3.35906634
119fertilization (GO:0009566)3.35279372
120negative regulation of muscle hypertrophy (GO:0014741)3.34758695
121positive regulation of microtubule polymerization (GO:0031116)3.33955629
122regulation of histone H3-K4 methylation (GO:0051569)3.33427518
123microtubule nucleation (GO:0007020)3.28658182
124positive regulation of granulocyte differentiation (GO:0030854)3.28216039
125nucleus organization (GO:0006997)3.27967616
126reproduction (GO:0000003)3.26208889
127regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.25108085
128regulation of mitotic spindle checkpoint (GO:1903504)3.25108085
129membrane disassembly (GO:0030397)3.22980806
130nuclear envelope disassembly (GO:0051081)3.22980806
131regulation of chromatin silencing (GO:0031935)3.22926187
132negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.22150036
133regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.21822052
134negative regulation of execution phase of apoptosis (GO:1900118)3.21676638
135ventricular cardiac muscle cell development (GO:0055015)3.20378950
136cytoplasmic mRNA processing body assembly (GO:0033962)3.19643330
137regulation of histone methylation (GO:0031060)3.15580709
138positive regulation of humoral immune response (GO:0002922)3.15569482
139DNA replication-dependent nucleosome organization (GO:0034723)3.14296462
140DNA replication-dependent nucleosome assembly (GO:0006335)3.14296462
141notochord development (GO:0030903)3.13945394
142meiotic cell cycle process (GO:1903046)3.10239823
143mitotic spindle checkpoint (GO:0071174)3.10120532
144negative regulation of cell division (GO:0051782)3.09460621
145negative regulation of nuclear division (GO:0051784)3.09413598
146regulation of corticosteroid hormone secretion (GO:2000846)3.08987525
147glandular epithelial cell development (GO:0002068)3.08225581
148mitotic sister chromatid cohesion (GO:0007064)3.07569616
149positive regulation of Cdc42 GTPase activity (GO:0043089)3.06786376
150protein monoubiquitination (GO:0006513)3.06326803
151spermatid nucleus differentiation (GO:0007289)3.05794369
152regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.04504934
153sister chromatid cohesion (GO:0007062)3.04327567
154chaperone-mediated protein transport (GO:0072321)3.00425242
155negative regulation of homotypic cell-cell adhesion (GO:0034111)2.98417325
156positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.98075731
157positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.98075731
158positive regulation of mitotic sister chromatid separation (GO:1901970)2.98075731
159negative regulation of histone modification (GO:0031057)2.94602876

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.84349362
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse6.28949108
3FOXM1_23109430_ChIP-Seq_U2OS_Human5.78871675
4SMAD_19615063_ChIP-ChIP_OVARY_Human4.46646812
5KAP1_22055183_ChIP-Seq_ESCs_Mouse4.38804476
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.02477755
7AR_21909140_ChIP-Seq_LNCAP_Human3.45406893
8KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.38065080
9KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.38065080
10KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.38065080
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.28145356
12E2F7_22180533_ChIP-Seq_HELA_Human3.26616793
13NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.02137823
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.86616315
15GATA1_26923725_Chip-Seq_HPCs_Mouse2.78392969
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.63360558
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.54396005
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.37572343
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.11593191
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.09863910
21GBX2_23144817_ChIP-Seq_PC3_Human2.09856346
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.00665819
23EZH2_22144423_ChIP-Seq_EOC_Human11.6241350
24LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.99967468
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.97546050
26BP1_19119308_ChIP-ChIP_Hs578T_Human1.96411573
27RUNX1_26923725_Chip-Seq_HPCs_Mouse1.89923904
28SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.83872770
29IGF1R_20145208_ChIP-Seq_DFB_Human1.79391741
30MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.79333055
31RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75158637
32MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.73400424
33AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.64659832
34IRF1_19129219_ChIP-ChIP_H3396_Human1.64631880
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63649324
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.60514998
37CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59028507
38TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.49550316
39* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.48938556
40RNF2_27304074_Chip-Seq_NSC_Mouse1.48177828
41MYC_18940864_ChIP-ChIP_HL60_Human1.47523245
42FUS_26573619_Chip-Seq_HEK293_Human1.45519731
43PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.43335972
44UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.41536608
45CBP_20019798_ChIP-Seq_JUKART_Human1.40113431
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40113431
47TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.40012487
48TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38562043
49E2F1_21310950_ChIP-Seq_MCF-7_Human1.37847548
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.37026717
51E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.36758945
52STAT1_17558387_ChIP-Seq_HELA_Human1.36129137
53NANOG_18555785_Chip-Seq_ESCs_Mouse1.35801080
54SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.33615317
55FOXM1_26456572_ChIP-Seq_MCF-7_Human1.32238510
56KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.29815358
57CDX2_22108803_ChIP-Seq_LS180_Human1.28731882
58ELK4_26923725_Chip-Seq_MESODERM_Mouse1.28161058
59PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.27489149
60ESR1_20079471_ChIP-ChIP_T-47D_Human1.24899583
61KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.23810322
62STAT3_23295773_ChIP-Seq_U87_Human1.22964139
63TCF4_23295773_ChIP-Seq_U87_Human1.21813977
64CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.21129961
65SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21099009
66SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.19650170
67TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18831176
68POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18831176
69RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.18791767
70ERG_20517297_ChIP-Seq_VCAP_Human1.17111596
71AUTS2_25519132_ChIP-Seq_293T-REX_Human1.16577946
72SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16012172
73CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14295263
74MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.13086926
75CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.11368207
76TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09710473
77GATA3_21867929_ChIP-Seq_TH1_Mouse1.09204038
78NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.08789886
79EP300_21415370_ChIP-Seq_HL-1_Mouse1.08719167
80SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.08602272
81SMAD4_21799915_ChIP-Seq_A2780_Human1.07644332
82AR_25329375_ChIP-Seq_VCAP_Human1.06405640
83HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.06399794
84P300_19829295_ChIP-Seq_ESCs_Human1.04673034
85VDR_22108803_ChIP-Seq_LS180_Human1.04553831
86AR_21572438_ChIP-Seq_LNCaP_Human1.04369656
87CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.03535369
88TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.03450130
89STAT6_21828071_ChIP-Seq_BEAS2B_Human1.02308006
90NFE2_27457419_Chip-Seq_LIVER_Mouse1.02121164
91TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.01554288
92KLF4_18555785_Chip-Seq_ESCs_Mouse0.99420418
93AHR_22903824_ChIP-Seq_MCF-7_Human0.99347114
94KDM2B_26808549_Chip-Seq_REH_Human0.99118980
95NANOG_21062744_ChIP-ChIP_HESCs_Human0.98466480
96TAL1_26923725_Chip-Seq_HPCs_Mouse0.98228733
97STAT3_18555785_Chip-Seq_ESCs_Mouse0.97988280
98EZH2_27294783_Chip-Seq_NPCs_Mouse0.96584815
99SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95620732
100SALL4_22934838_ChIP-ChIP_CD34+_Human0.95424893
101LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95293249
102GF1B_26923725_Chip-Seq_HPCs_Mouse0.95068749
103RUNX2_22187159_ChIP-Seq_PCA_Human0.94311863
104PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94209915
105SOX2_18555785_Chip-Seq_ESCs_Mouse0.94057618
106TP63_19390658_ChIP-ChIP_HaCaT_Human0.94026147
107CTCF_18555785_Chip-Seq_ESCs_Mouse0.93807591
108EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.93716748
109PKCTHETA_26484144_Chip-Seq_BREAST_Human0.93686791
110EWS_26573619_Chip-Seq_HEK293_Human0.93244732
111SMAD4_21741376_ChIP-Seq_EPCs_Human0.92362936
112NFYA_21822215_ChIP-Seq_K562_Human0.92349599
113KAP1_27257070_Chip-Seq_ESCs_Mouse0.92074075
114GF1_26923725_Chip-Seq_HPCs_Mouse0.91684845
115CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91280607
116NMYC_18555785_Chip-Seq_ESCs_Mouse0.90679612
117FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90116871
118EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.89485557
119EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.89418240
120CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.89299359
121FOXH1_21741376_ChIP-Seq_EPCs_Human0.88386750
122NANOG_18555785_ChIP-Seq_MESCs_Mouse0.87218649
123PRDM14_20953172_ChIP-Seq_ESCs_Human0.86657437
124PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.86531695
125PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.85709188
126RBPJ_22232070_ChIP-Seq_NCS_Mouse0.84995268
127* NANOG_20526341_ChIP-Seq_ESCs_Human0.84964683
128MYCN_18555785_ChIP-Seq_MESCs_Mouse0.84218796
129CMYC_18555785_Chip-Seq_ESCs_Mouse0.83983166
130TBL1_22424771_ChIP-Seq_293T_Human0.83969761
131ESRRB_18555785_Chip-Seq_ESCs_Mouse0.82396259
132* CBP_21632823_ChIP-Seq_H3396_Human0.82036653
133ARNT_22903824_ChIP-Seq_MCF-7_Human0.82002583
134GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.80115829
135SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.79642943
136ZNF217_24962896_ChIP-Seq_MCF-7_Human0.77897846
137SMRT_27268052_Chip-Seq_Bcells_Human0.76709079
138TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.76688369
139KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.76180484
140SMAD3_21741376_ChIP-Seq_EPCs_Human0.75728345
141DROSHA_22980978_ChIP-Seq_HELA_Human0.75523238
142NR3C1_23031785_ChIP-Seq_PC12_Mouse0.74041718
143PADI4_21655091_ChIP-ChIP_MCF-7_Human0.72610336
144OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.71309144
145STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.71142672
146BMI1_23680149_ChIP-Seq_NPCS_Mouse0.70730803
147ER_23166858_ChIP-Seq_MCF-7_Human0.70551390
148FOXA1_27270436_Chip-Seq_PROSTATE_Human0.69543627
149FOXA1_25329375_ChIP-Seq_VCAP_Human0.69543627
150SOX2_19829295_ChIP-Seq_ESCs_Human0.68826446
151NANOG_19829295_ChIP-Seq_ESCs_Human0.68826446
152ESR1_15608294_ChIP-ChIP_MCF-7_Human0.68813429
153CTBP2_25329375_ChIP-Seq_LNCAP_Human0.67357125
154TP53_22573176_ChIP-Seq_HFKS_Human0.66976587

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition5.97655829
2MP0002102_abnormal_ear_morphology5.88960612
3MP0003646_muscle_fatigue5.71286688
4MP0003718_maternal_effect5.35516379
5MP0008789_abnormal_olfactory_epithelium5.12161567
6MP0005499_abnormal_olfactory_system4.37011707
7MP0005394_taste/olfaction_phenotype4.37011707
8MP0003693_abnormal_embryo_hatching3.74104178
9MP0002653_abnormal_ependyma_morphology3.64518077
10MP0008877_abnormal_DNA_methylation3.31835827
11MP0003890_abnormal_embryonic-extraembry3.18010194
12MP0002138_abnormal_hepatobiliary_system3.14828887
13MP0010094_abnormal_chromosome_stability2.94034641
14MP0003123_paternal_imprinting2.79013695
15MP0005360_urolithiasis2.78913273
16MP0005408_hypopigmentation2.72396561
17MP0003111_abnormal_nucleus_morphology2.65173697
18MP0002234_abnormal_pharynx_morphology2.63022225
19MP0001119_abnormal_female_reproductive2.62907813
20MP0003077_abnormal_cell_cycle2.58451626
21MP0005395_other_phenotype2.57227170
22MP0003699_abnormal_female_reproductive2.55642097
23MP0002249_abnormal_larynx_morphology2.43392056
24MP0003183_abnormal_peptide_metabolism2.31224427
25MP0004957_abnormal_blastocyst_morpholog2.24977927
26MP0008057_abnormal_DNA_replication2.24611423
27MP0005410_abnormal_fertilization2.24234577
28MP0000653_abnormal_sex_gland2.13371033
29MP0001929_abnormal_gametogenesis2.11398521
30MP0006292_abnormal_olfactory_placode2.09493005
31MP0003879_abnormal_hair_cell2.02092257
32MP0000579_abnormal_nail_morphology1.92058467
33MP0003787_abnormal_imprinting1.91962425
34MP0002210_abnormal_sex_determination1.91413743
35MP0000462_abnormal_digestive_system1.82189171
36MP0003937_abnormal_limbs/digits/tail_de1.76189402
37MP0001984_abnormal_olfaction1.72431361
38MP0003121_genomic_imprinting1.71129254
39MP0010234_abnormal_vibrissa_follicle1.70153012
40MP0002160_abnormal_reproductive_system1.65041812
41MP0001529_abnormal_vocalization1.63480787
42MP0005646_abnormal_pituitary_gland1.61644692
43MP0010368_abnormal_lymphatic_system1.58884529
44MP0008932_abnormal_embryonic_tissue1.55640297
45MP0000566_synostosis1.47199218
46MP0001145_abnormal_male_reproductive1.43606405
47MP0003252_abnormal_bile_duct1.42486706
48MP0001293_anophthalmia1.41181940
49MP0004185_abnormal_adipocyte_glucose1.39321368
50MP0002161_abnormal_fertility/fecundity1.38608789
51MP0000639_abnormal_adrenal_gland1.33634050
52MP0000762_abnormal_tongue_morphology1.33143037
53MP0002085_abnormal_embryonic_tissue1.29215328
54MP0001905_abnormal_dopamine_level1.28734111
55MP0005310_abnormal_salivary_gland1.28232771
56MP0004145_abnormal_muscle_electrophysio1.21972578
57MP0001915_intracranial_hemorrhage1.19867566
58MP0008007_abnormal_cellular_replicative1.18262491
59MP0004510_myositis1.16881262
60MP0001697_abnormal_embryo_size1.13707938
61MP0003315_abnormal_perineum_morphology1.12288507
62MP0000350_abnormal_cell_proliferation1.11570535
63MP0001730_embryonic_growth_arrest1.06867563
64MP0005085_abnormal_gallbladder_physiolo1.03789677
65MP0010386_abnormal_urinary_bladder1.03254308
66MP0002084_abnormal_developmental_patter1.02876606
67MP0004264_abnormal_extraembryonic_tissu1.01303926
68MP0005389_reproductive_system_phenotype1.00851846
69MP0002877_abnormal_melanocyte_morpholog0.97837894
70MP0003656_abnormal_erythrocyte_physiolo0.96941905
71MP0001851_eye_inflammation0.95774390
72MP0010678_abnormal_skin_adnexa0.90549710
73MP0004270_analgesia0.88821367
74MP0003950_abnormal_plasma_membrane0.86034079
75MP0003698_abnormal_male_reproductive0.84355018
76MP0003119_abnormal_digestive_system0.83734108
77MP0008260_abnormal_autophagy0.83489661
78MP0002019_abnormal_tumor_incidence0.82025354
79MP0003755_abnormal_palate_morphology0.81789225
80MP0003329_amyloid_beta_deposits0.80868759
81MP0003453_abnormal_keratinocyte_physiol0.80367255
82MP0001346_abnormal_lacrimal_gland0.79234217
83MP0002272_abnormal_nervous_system0.78351908
84MP0001672_abnormal_embryogenesis/_devel0.78021198
85MP0005380_embryogenesis_phenotype0.78021198
86MP0009250_abnormal_appendicular_skeleto0.76992847
87MP0005551_abnormal_eye_electrophysiolog0.76766899
88MP0000427_abnormal_hair_cycle0.76365122
89MP0002177_abnormal_outer_ear0.76179128
90MP0003868_abnormal_feces_composition0.76041249
91MP0004142_abnormal_muscle_tone0.75316044
92MP0005187_abnormal_penis_morphology0.75152715
93MP0002796_impaired_skin_barrier0.74180603
94MP0001666_abnormal_nutrient_absorption0.73781018
95MP0000678_abnormal_parathyroid_gland0.73330734
96MP0001986_abnormal_taste_sensitivity0.72844840
97MP0005647_abnormal_sex_gland0.68182571
98MP0000490_abnormal_crypts_of0.67538792
99MP0001324_abnormal_eye_pigmentation0.66678074
100MP0002638_abnormal_pupillary_reflex0.65200485
101MP0002168_other_aberrant_phenotype0.64484634
102MP0000049_abnormal_middle_ear0.63878511
103MP0005621_abnormal_cell_physiology0.63224757
104MP0002928_abnormal_bile_duct0.62105946
105MP0002116_abnormal_craniofacial_bone0.61144007
106MP0000534_abnormal_ureter_morphology0.60590088
107MP0009840_abnormal_foam_cell0.60496386
108MP0002837_dystrophic_cardiac_calcinosis0.59240397
109MP0008058_abnormal_DNA_repair0.57606180
110MP0001502_abnormal_circadian_rhythm0.57490553
111MP0002396_abnormal_hematopoietic_system0.56896249
112MP0006276_abnormal_autonomic_nervous0.56831049
113MP0001664_abnormal_digestion0.56785141
114MP0000631_abnormal_neuroendocrine_gland0.56104305
115MP0004782_abnormal_surfactant_physiolog0.54305916
116MP0002282_abnormal_trachea_morphology0.54105245
117MP0002233_abnormal_nose_morphology0.53930323
118MP0003861_abnormal_nervous_system0.52580567
119MP0005508_abnormal_skeleton_morphology0.52567320
120MP0002080_prenatal_lethality0.51909611
121MP0000432_abnormal_head_morphology0.51807352
122MP0003632_abnormal_nervous_system0.51380971
123MP0005501_abnormal_skin_physiology0.51154967
124MP0002086_abnormal_extraembryonic_tissu0.50967508
125MP0003984_embryonic_growth_retardation0.50679973
126MP0001849_ear_inflammation0.50504681
127MP0005503_abnormal_tendon_morphology0.50262143
128MP0010030_abnormal_orbit_morphology0.50117994
129MP0002090_abnormal_vision0.49432072
130MP0002109_abnormal_limb_morphology0.49228578
131MP0002089_abnormal_postnatal_growth/wei0.48717691
132MP0001963_abnormal_hearing_physiology0.48309419
133MP0009780_abnormal_chondrocyte_physiolo0.47579844
134MP0000613_abnormal_salivary_gland0.47379257
135MP0002088_abnormal_embryonic_growth/wei0.47136534
136MP0003935_abnormal_craniofacial_develop0.46697165
137MP0002139_abnormal_hepatobiliary_system0.46649758
138MP0004043_abnormal_pH_regulation0.46370102
139MP0005075_abnormal_melanosome_morpholog0.46332733
140MP0009384_cardiac_valve_regurgitation0.46310355
141MP0006138_congestive_heart_failure0.45395479
142MP0002295_abnormal_pulmonary_circulatio0.44320433
143MP0002932_abnormal_joint_morphology0.44108724
144MP0010307_abnormal_tumor_latency0.43595461
145MP0003136_yellow_coat_color0.43297467
146MP0003941_abnormal_skin_development0.41762062
147MP0004084_abnormal_cardiac_muscle0.41283827
148MP0000377_abnormal_hair_follicle0.37220997
149MP0002751_abnormal_autonomic_nervous0.36789288
150MP0000428_abnormal_craniofacial_morphol0.35993415
151MP0002127_abnormal_cardiovascular_syste0.34950931
152MP0000026_abnormal_inner_ear0.33993461
153MP0001756_abnormal_urination0.32161454
154MP0000015_abnormal_ear_pigmentation0.30983112
155MP0005319_abnormal_enzyme/_coenzyme0.30690537
156MP0006072_abnormal_retinal_apoptosis0.29493318

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)8.40132510
2Papillary thyroid carcinoma (HP:0002895)5.28547199
3Cholecystitis (HP:0001082)5.19101865
4Abnormal gallbladder physiology (HP:0012438)5.19101865
5Abdominal situs inversus (HP:0003363)4.93600546
6Abnormality of abdominal situs (HP:0011620)4.93600546
7Osteomalacia (HP:0002749)4.65320434
8Birth length less than 3rd percentile (HP:0003561)4.56492408
9Breast hypoplasia (HP:0003187)4.46554412
10Facial hemangioma (HP:0000329)4.42480942
11Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)4.39473738
12Septo-optic dysplasia (HP:0100842)4.39471676
13Shawl scrotum (HP:0000049)4.34972346
14Adrenal hypoplasia (HP:0000835)4.30113433
15Abnormality of the labia minora (HP:0012880)4.28544274
16Chromsome breakage (HP:0040012)4.23719454
17Flat capital femoral epiphysis (HP:0003370)4.18380340
18Absent septum pellucidum (HP:0001331)4.07280765
19Patellar aplasia (HP:0006443)4.07184540
20Median cleft lip (HP:0000161)4.01223888
21Hypophosphatemic rickets (HP:0004912)3.99555898
22Short tibia (HP:0005736)3.96503505
23Azoospermia (HP:0000027)3.95793807
24Chromosomal breakage induced by crosslinking agents (HP:0003221)3.91961993
25Secondary amenorrhea (HP:0000869)3.88682407
26Arterial tortuosity (HP:0005116)3.79881164
27Aplasia/Hypoplasia of the patella (HP:0006498)3.76066987
28Impulsivity (HP:0100710)3.68171592
29Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.65207109
30Abnormality of the septum pellucidum (HP:0007375)3.61280505
31Gonadotropin excess (HP:0000837)3.57906415
32Aplasia/Hypoplasia of the tibia (HP:0005772)3.53702862
33Capillary hemangiomas (HP:0005306)3.49057850
34Fair hair (HP:0002286)3.42839389
35Stillbirth (HP:0003826)3.37436758
36Premature ovarian failure (HP:0008209)3.34929520
37Vascular tortuosity (HP:0004948)3.28752450
38Cortical dysplasia (HP:0002539)3.26619416
39Spondylolisthesis (HP:0003302)3.26606498
40Pulmonary fibrosis (HP:0002206)3.17985027
41Breast aplasia (HP:0100783)3.16364853
42Aplasia/Hypoplasia of the breasts (HP:0010311)3.14634416
43Abnormality of lateral ventricle (HP:0030047)3.12905593
44Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.12644534
45Abnormality of the fingertips (HP:0001211)3.05990731
46Hypergonadotropic hypogonadism (HP:0000815)3.04377325
47Infertility (HP:0000789)3.02113638
48Abnormal spermatogenesis (HP:0008669)2.99635631
49Abnormality of chromosome segregation (HP:0002916)2.95945123
50Oligodactyly (hands) (HP:0001180)2.91560623
51Acute myeloid leukemia (HP:0004808)2.88580748
52Thyroid carcinoma (HP:0002890)2.83597510
53Intrahepatic cholestasis (HP:0001406)2.81207115
54Sandal gap (HP:0001852)2.80070852
55Supernumerary spleens (HP:0009799)2.74769032
56Abnormal ciliary motility (HP:0012262)2.71400594
57Chronic bronchitis (HP:0004469)2.70118031
58Urethral obstruction (HP:0000796)2.66431074
59Bile duct proliferation (HP:0001408)2.64014986
60Abnormal biliary tract physiology (HP:0012439)2.64014986
61Wrist flexion contracture (HP:0001239)2.58252311
62Overlapping toe (HP:0001845)2.55931246
63Abnormality of chromosome stability (HP:0003220)2.53036966
64Cystic hygroma (HP:0000476)2.51546338
65Nonprogressive disorder (HP:0003680)2.51489642
66Lip pit (HP:0100267)2.51315232
67Insulin-resistant diabetes mellitus (HP:0000831)2.49941183
68Generalized hypopigmentation of hair (HP:0011358)2.49873534
69Apathy (HP:0000741)2.49796878
70Oligodactyly (HP:0012165)2.49413525
71Conjunctival telangiectasia (HP:0000524)2.49313147
72Spinal cord compression (HP:0002176)2.49236886
73Sensory axonal neuropathy (HP:0003390)2.48451449
74Hypokinesia (HP:0002375)2.48055297
75Metaphyseal irregularity (HP:0003025)2.46556535
76Shallow orbits (HP:0000586)2.43011722
77Diminished motivation (HP:0000745)2.42686287
78Aplasia/Hypoplasia of the tongue (HP:0010295)2.42259605
79Abnormal lung lobation (HP:0002101)2.40045909
80Type 2 muscle fiber atrophy (HP:0003554)2.39649553
81Heterotopia (HP:0002282)2.39073646
82Primary amenorrhea (HP:0000786)2.38289002
83Maternal diabetes (HP:0009800)2.37449045
84Abnormality of the fovea (HP:0000493)2.36784879
85Hip contracture (HP:0003273)2.36396618
86Bicornuate uterus (HP:0000813)2.35040949
87Hypoplasia of the fovea (HP:0007750)2.30766488
88Aplasia/Hypoplasia of the fovea (HP:0008060)2.30766488
89Aplasia/Hypoplasia of the macula (HP:0008059)2.30265894
90Aplasia/Hypoplasia of the uvula (HP:0010293)2.28092180
91Muscle fiber atrophy (HP:0100295)2.24593815
92Nephroblastoma (Wilms tumor) (HP:0002667)2.23903167
93Truncal obesity (HP:0001956)2.23181909
94Carpal bone hypoplasia (HP:0001498)2.22840187
95Rib fusion (HP:0000902)2.21910508
96Abnormality of the epiphysis of the femoral head (HP:0010574)2.21554750
97Abnormal respiratory motile cilium physiology (HP:0012261)2.20527368
98Abnormality of the preputium (HP:0100587)2.20342259
99Absent radius (HP:0003974)2.20156108
100Proximal tubulopathy (HP:0000114)2.19823550
101Muscle stiffness (HP:0003552)2.13515843
102Absent forearm bone (HP:0003953)2.12419392
103Aplasia involving forearm bones (HP:0009822)2.12419392
104Midline defect of the nose (HP:0004122)2.11965932
105Abnormality of aromatic amino acid family metabolism (HP:0004338)2.11667530
106Meckel diverticulum (HP:0002245)2.11458306
107Pancreatic fibrosis (HP:0100732)2.11417879
108Aplasia/Hypoplasia involving the musculature (HP:0001460)2.10689250
109Congenital sensorineural hearing impairment (HP:0008527)2.10687377
110Lower limb hyperreflexia (HP:0002395)2.10458896
111Embryonal renal neoplasm (HP:0011794)2.10332793
112Aplasia/Hypoplasia affecting the retina (HP:0008061)2.09594300
113Anterior segment dysgenesis (HP:0007700)2.09506723
114Hypoplastic iliac wings (HP:0002866)2.07524348
115Rhinitis (HP:0012384)2.07293504
116Dysdiadochokinesis (HP:0002075)2.06798281
117Fibular aplasia (HP:0002990)2.06180454
118Aplasia/Hypoplasia of the sternum (HP:0006714)2.05205537
119Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.04943507
120Limb hypertonia (HP:0002509)2.04513872
121Dynein arm defect of respiratory motile cilia (HP:0012255)2.03861414
122Absent/shortened dynein arms (HP:0200106)2.03861414
123Abnormality of the femoral head (HP:0003368)2.03814791
124Aplastic anemia (HP:0001915)2.02804310
125Bundle branch block (HP:0011710)2.02093440
126Sparse lateral eyebrow (HP:0005338)2.01958337
127Camptodactyly of toe (HP:0001836)2.01672857
128Skin pits (HP:0100276)2.00052511
129Abnormality of femoral epiphyses (HP:0006499)1.99885523
130Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.99885523
131Abnormality of the phalanges of the hallux (HP:0010057)1.98858135
132Fetal akinesia sequence (HP:0001989)1.98753883
133Prostate neoplasm (HP:0100787)1.98516386
134Posterior subcapsular cataract (HP:0007787)1.98315631
135Enlarged penis (HP:0000040)1.96662523
136Abnormality of the proximal phalanges of the hand (HP:0009834)1.96364454
137Hydroureter (HP:0000072)1.96075566
138Abnormality of the ileum (HP:0001549)1.95322802
139Decreased muscle mass (HP:0003199)1.94538353
140Amniotic constriction ring (HP:0009775)1.94017003
141Abnormality of placental membranes (HP:0011409)1.94017003
142Abnormality of the vasculature of the conjunctiva (HP:0008054)1.92255521
143Abnormality of monocarboxylic acid metabolism (HP:0010996)1.92088024
144Aplasia of the musculature (HP:0100854)1.91670366
145Small intestinal stenosis (HP:0012848)1.90286576
146Duodenal stenosis (HP:0100867)1.90286576
147Myelodysplasia (HP:0002863)1.89810629
148Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.88264642
149Striae distensae (HP:0001065)1.88217129
150Absent hand (HP:0004050)1.87357582
151Short thumb (HP:0009778)1.86851823
152Irregular epiphyses (HP:0010582)1.85952200
153Generalized aminoaciduria (HP:0002909)1.85392047
154Tetany (HP:0001281)1.85130219
155Arachnodactyly (HP:0001166)1.84592324
156Ankle contracture (HP:0006466)1.84301721
157Hyperglycemia (HP:0003074)1.83910740
158Oral leukoplakia (HP:0002745)1.82671526
159Retrobulbar optic neuritis (HP:0100654)1.82575300
160Optic neuritis (HP:0100653)1.82575300
161Microglossia (HP:0000171)1.81539836
162Abnormality of the labia (HP:0000058)1.81051622
163Optic nerve hypoplasia (HP:0000609)1.79884481
164Malnutrition (HP:0004395)1.79791682
165Cafe-au-lait spot (HP:0000957)1.78619965
166Ectopic kidney (HP:0000086)1.78289981
167Cone-rod dystrophy (HP:0000548)1.77163534
168Clubbing of toes (HP:0100760)1.76812967
169Sloping forehead (HP:0000340)1.76096748

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MUSK4.11177666
2KSR24.08342194
3EEF2K3.85127082
4MAP3K63.84134878
5NEK63.56539365
6LATS13.49914618
7MAP3K93.36991343
8ERBB43.31027014
9LATS23.29967871
10PLK43.21391701
11BRAF3.10700419
12TAOK33.00631792
13MAP3K133.00512577
14MOS2.82435494
15MET2.80257613
16RAF12.73931670
17TTK2.66366406
18ARAF2.65044865
19MAPKAPK32.56985035
20STK38L2.45156109
21TAOK12.33284213
22KSR11.96393999
23EIF2AK31.94879841
24CDC71.83894195
25PAK61.74054594
26BMPR21.70768242
27CDK81.55286790
28CDK121.51752925
29MELK1.49227524
30MAPKAPK51.47368381
31STK31.41062865
32CDK91.36254327
33ZAK1.32102887
34NEK21.31258412
35MST41.27833295
36TNIK1.25829624
37MAPK131.23981075
38PRKD31.11474631
39DYRK21.10800032
40CHEK21.10048475
41TRPM71.07016634
42STK391.06618834
43PLK11.06164832
44MAP3K41.04410726
45TIE10.98480749
46RPS6KB20.86724514
47PIM10.85081147
48STK100.84809124
49MAP3K80.84042563
50TRIM280.79456178
51PRKD20.76411707
52PRKAA20.74704689
53DMPK0.72824827
54ACVR1B0.72043203
55MARK30.71752862
56ABL20.71333709
57MARK20.69789911
58MAP2K70.68863621
59STK380.67242386
60NEK90.67197091
61TNK20.65088057
62TYRO30.62920164
63RET0.58899219
64PRKG10.58634589
65PLK30.58576105
66AURKB0.57505216
67CSNK1D0.57210279
68PRKAA10.55670165
69MAP2K40.55629790
70BUB10.54177818
71AURKA0.52587951
72TGFBR10.48244223
73MAPK110.47618402
74MAP3K10.47505764
75OXSR10.47378444
76MAP3K50.46434932
77STK240.45714675
78CHUK0.45353490
79WNK10.43764616
80ATR0.43645316
81NLK0.42269255
82CSNK1G10.42149789
83NUAK10.41650489
84LMTK20.40856127
85PKN10.40660974
86SGK20.40437694
87MAP2K10.37938842
88EPHA30.37251670
89PINK10.36970512
90NTRK30.36910223
91PTK20.36696809
92NTRK20.35308530
93BRSK10.35186566
94CAMK2A0.34634731
95CSNK1G20.34580103
96PRKCZ0.34375601
97PRKACA0.31673646
98ATM0.31173320
99CSNK1G30.30595416
100CHEK10.30389517
101PRKACB0.28383656
102CSNK1E0.27879510
103PAK30.27761211
104CDK50.27622538
105VRK10.26801057
106LRRK20.26110743
107SGK4940.25882058
108SGK2230.25882058
109CDK30.25723539
110FGR0.24757880
111MAPK10.24485419
112BMPR1B0.24357088
113MTOR0.22461912
114EGFR0.21044270
115JAK30.19754417
116CDK70.18957177
117CDK10.18665815
118PDK10.17865069
119JAK20.17764931
120GSK3B0.17034864
121EIF2AK20.16706268
122HIPK20.16312324
123ABL10.16304264
124PAK10.15137140
125CSNK1A1L0.14750459
126CDK20.14166648
127CDK150.13917743
128MAP3K120.13093860
129CDK180.12142887
130CDK40.11132456
131PBK0.10181102
132EPHA40.09885807
133SRPK10.09858051
134PRKCI0.09464345
135BRSK20.09460389
136AKT20.09446586
137SGK30.08852296
138TLK10.08613262
139KIT0.08365220
140CDK190.07005053
141MAPK30.06135793
142BRD40.06041408

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041104.37993927
2Ovarian steroidogenesis_Homo sapiens_hsa049133.96037629
3Caffeine metabolism_Homo sapiens_hsa002323.95991135
4Vitamin B6 metabolism_Homo sapiens_hsa007503.42582704
5Basal transcription factors_Homo sapiens_hsa030223.17527723
6Circadian rhythm_Homo sapiens_hsa047103.17208199
7* RNA degradation_Homo sapiens_hsa030182.97397398
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.55358757
9Linoleic acid metabolism_Homo sapiens_hsa005912.50877477
10Pancreatic cancer_Homo sapiens_hsa052122.50355881
11Oocyte meiosis_Homo sapiens_hsa041142.49851408
12Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.37440087
13Ether lipid metabolism_Homo sapiens_hsa005652.21664457
14Olfactory transduction_Homo sapiens_hsa047402.15241186
15TGF-beta signaling pathway_Homo sapiens_hsa043502.10790114
16Homologous recombination_Homo sapiens_hsa034401.95879995
17GnRH signaling pathway_Homo sapiens_hsa049121.85790003
18p53 signaling pathway_Homo sapiens_hsa041151.82671533
19Fanconi anemia pathway_Homo sapiens_hsa034601.77451260
20RNA polymerase_Homo sapiens_hsa030201.65316197
21Colorectal cancer_Homo sapiens_hsa052101.57849527
22Prolactin signaling pathway_Homo sapiens_hsa049171.57358320
23Base excision repair_Homo sapiens_hsa034101.56259753
24Choline metabolism in cancer_Homo sapiens_hsa052311.53997702
25RNA transport_Homo sapiens_hsa030131.52314191
26Dorso-ventral axis formation_Homo sapiens_hsa043201.51264147
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.49588450
28Nicotine addiction_Homo sapiens_hsa050331.43491957
29Gap junction_Homo sapiens_hsa045401.39047018
30VEGF signaling pathway_Homo sapiens_hsa043701.32245521
31MicroRNAs in cancer_Homo sapiens_hsa052061.30929477
32Renal cell carcinoma_Homo sapiens_hsa052111.27994465
33Nucleotide excision repair_Homo sapiens_hsa034201.25995781
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.23268525
35DNA replication_Homo sapiens_hsa030301.22437090
36Phototransduction_Homo sapiens_hsa047441.17072145
37ABC transporters_Homo sapiens_hsa020101.15378890
38Long-term depression_Homo sapiens_hsa047301.10150880
39Synaptic vesicle cycle_Homo sapiens_hsa047211.10102358
40Non-homologous end-joining_Homo sapiens_hsa034501.06301715
41Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.05050028
42Mismatch repair_Homo sapiens_hsa034301.03834225
43SNARE interactions in vesicular transport_Homo sapiens_hsa041301.01133634
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.00795905
45Endometrial cancer_Homo sapiens_hsa052130.99402980
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.99323583
47Thyroid cancer_Homo sapiens_hsa052160.99118852
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.96273385
49Adherens junction_Homo sapiens_hsa045200.94456564
50Hippo signaling pathway_Homo sapiens_hsa043900.94231253
51Glycerophospholipid metabolism_Homo sapiens_hsa005640.93421346
52Morphine addiction_Homo sapiens_hsa050320.93139969
53mRNA surveillance pathway_Homo sapiens_hsa030150.91635665
54FoxO signaling pathway_Homo sapiens_hsa040680.91607574
55Vitamin digestion and absorption_Homo sapiens_hsa049770.89479185
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.88451525
57Bile secretion_Homo sapiens_hsa049760.85227656
58GABAergic synapse_Homo sapiens_hsa047270.84285585
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.83671977
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.83075844
61Ras signaling pathway_Homo sapiens_hsa040140.79011481
62Small cell lung cancer_Homo sapiens_hsa052220.78296556
63Bladder cancer_Homo sapiens_hsa052190.77850220
64Notch signaling pathway_Homo sapiens_hsa043300.76760809
65Chronic myeloid leukemia_Homo sapiens_hsa052200.75564140
66Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.75455897
67Non-small cell lung cancer_Homo sapiens_hsa052230.75387212
68mTOR signaling pathway_Homo sapiens_hsa041500.71241881
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70639768
70Hepatitis B_Homo sapiens_hsa051610.70508294
71Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.69790330
72Other glycan degradation_Homo sapiens_hsa005110.68809388
73Estrogen signaling pathway_Homo sapiens_hsa049150.67765564
74Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64678203
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64030371
76Arachidonic acid metabolism_Homo sapiens_hsa005900.60802071
77Pyrimidine metabolism_Homo sapiens_hsa002400.57931836
78Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55939682
79Serotonergic synapse_Homo sapiens_hsa047260.55538986
80ErbB signaling pathway_Homo sapiens_hsa040120.55432508
81Prostate cancer_Homo sapiens_hsa052150.53346702
82Fatty acid elongation_Homo sapiens_hsa000620.52508799
83MAPK signaling pathway_Homo sapiens_hsa040100.51648638
84HTLV-I infection_Homo sapiens_hsa051660.50973195
85Purine metabolism_Homo sapiens_hsa002300.50614785
86Folate biosynthesis_Homo sapiens_hsa007900.50141817
87Inositol phosphate metabolism_Homo sapiens_hsa005620.47996128
88Glioma_Homo sapiens_hsa052140.46369931
89Taste transduction_Homo sapiens_hsa047420.42638281
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41726639
91Glutamatergic synapse_Homo sapiens_hsa047240.39523868
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.39387231
93Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37490089
94Shigellosis_Homo sapiens_hsa051310.36053288
95cGMP-PKG signaling pathway_Homo sapiens_hsa040220.34727185
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.34433620
97Glycosaminoglycan degradation_Homo sapiens_hsa005310.34148769
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.33638716
99Melanoma_Homo sapiens_hsa052180.33220500
100Herpes simplex infection_Homo sapiens_hsa051680.32160559
101Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.31852471
102TNF signaling pathway_Homo sapiens_hsa046680.30178304
103Propanoate metabolism_Homo sapiens_hsa006400.29037194
104cAMP signaling pathway_Homo sapiens_hsa040240.27822846
105Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.27721581
106Pathways in cancer_Homo sapiens_hsa052000.27252546
107Oxytocin signaling pathway_Homo sapiens_hsa049210.26958485
108Wnt signaling pathway_Homo sapiens_hsa043100.26665775
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.25693037
110Regulation of autophagy_Homo sapiens_hsa041400.25492485
111Arginine and proline metabolism_Homo sapiens_hsa003300.25390544
112Sphingolipid metabolism_Homo sapiens_hsa006000.24201699
113Jak-STAT signaling pathway_Homo sapiens_hsa046300.23730148
114Transcriptional misregulation in cancer_Homo sapiens_hsa052020.19050135
115Phosphatidylinositol signaling system_Homo sapiens_hsa040700.18776534
116Epstein-Barr virus infection_Homo sapiens_hsa051690.18675152
117AMPK signaling pathway_Homo sapiens_hsa041520.18473869
118Arginine biosynthesis_Homo sapiens_hsa002200.17473387
119Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.16604614
120Phagosome_Homo sapiens_hsa041450.16531608
121Biosynthesis of amino acids_Homo sapiens_hsa012300.15313285
122Protein digestion and absorption_Homo sapiens_hsa049740.15217716
123Cocaine addiction_Homo sapiens_hsa050300.15085725
124Viral carcinogenesis_Homo sapiens_hsa052030.14803179
125Tight junction_Homo sapiens_hsa045300.14352984
126Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.14274765
127Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.13458639
128Drug metabolism - other enzymes_Homo sapiens_hsa009830.11872845
129Aldosterone synthesis and secretion_Homo sapiens_hsa049250.10612450
130Long-term potentiation_Homo sapiens_hsa047200.09217338
131Huntingtons disease_Homo sapiens_hsa050160.07078784
132Cholinergic synapse_Homo sapiens_hsa047250.06785217
133Circadian entrainment_Homo sapiens_hsa047130.05258936
134Rap1 signaling pathway_Homo sapiens_hsa040150.02166576
135Dopaminergic synapse_Homo sapiens_hsa047280.02101287

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