BTK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous antigen (GO:0019883)4.86880863
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.63742621
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.63742621
4* positive regulation of B cell differentiation (GO:0045579)4.45047741
5* B cell receptor signaling pathway (GO:0050853)4.43969753
6negative regulation of erythrocyte differentiation (GO:0045647)4.43913879
7positive regulation of gamma-delta T cell activation (GO:0046645)4.39808690
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.37458431
9negative regulation of cell killing (GO:0031342)4.36515843
10negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.36515843
11regulation of B cell receptor signaling pathway (GO:0050855)4.29305532
12negative regulation of phagocytosis (GO:0050765)4.24395025
13immunoglobulin mediated immune response (GO:0016064)4.15516829
14detection of other organism (GO:0098543)4.08032018
15neutrophil activation involved in immune response (GO:0002283)4.06783193
16regulation of interferon-beta biosynthetic process (GO:0045357)4.02859830
17detection of bacterium (GO:0016045)3.95403747
18negative regulation of interleukin-12 production (GO:0032695)3.85089763
19* regulation of B cell differentiation (GO:0045577)3.85056730
20respiratory burst (GO:0045730)3.84374942
21modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.79741073
22positive regulation by organism of defense response of other organism involved in symbiotic interact3.79741073
23modulation by symbiont of host immune response (GO:0052553)3.79741073
24positive regulation by symbiont of host defense response (GO:0052509)3.79741073
25modulation by symbiont of host defense response (GO:0052031)3.79741073
26modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.79741073
27Arp2/3 complex-mediated actin nucleation (GO:0034314)3.71230214
28ribosomal small subunit assembly (GO:0000028)3.69187872
29positive thymic T cell selection (GO:0045059)3.54274435
30positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.53139043
31mast cell activation (GO:0045576)3.46114600
32positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.43817403
33detection of external biotic stimulus (GO:0098581)3.39343391
34microglial cell activation (GO:0001774)3.36802563
35defense response to protozoan (GO:0042832)3.36168675
36B cell mediated immunity (GO:0019724)3.34140123
37regulation of myeloid leukocyte mediated immunity (GO:0002886)3.32080499
38response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.31786971
39response to host (GO:0075136)3.31786971
40response to host defenses (GO:0052200)3.31786971
41positive regulation of interferon-alpha production (GO:0032727)3.29829232
42cellular extravasation (GO:0045123)3.28345436
43positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.28313428
44response to peptidoglycan (GO:0032494)3.25296576
45T cell migration (GO:0072678)3.24426722
46definitive hemopoiesis (GO:0060216)3.24266131
47response to protozoan (GO:0001562)3.21775690
48regulation of leukocyte degranulation (GO:0043300)3.20826699
49cellular response to zinc ion (GO:0071294)3.20119199
50negative regulation of T cell mediated immunity (GO:0002710)3.16022400
51regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.15582883
52negative thymic T cell selection (GO:0045060)3.14711448
53myeloid dendritic cell activation (GO:0001773)3.14654252
54neutrophil activation (GO:0042119)3.13280884
55production of molecular mediator involved in inflammatory response (GO:0002532)3.11348624
56detection of molecule of bacterial origin (GO:0032490)3.10972017
57regulation of interferon-alpha production (GO:0032647)3.10362691
58negative regulation of lymphocyte mediated immunity (GO:0002707)3.08568065
59regulation of T-helper 1 cell differentiation (GO:0045625)3.08475944
60positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.07854396
61myeloid cell activation involved in immune response (GO:0002275)3.05556848
62macrophage activation (GO:0042116)3.03045482
63macrophage activation involved in immune response (GO:0002281)3.01882560
64positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.01573425
65regulation of alpha-beta T cell proliferation (GO:0046640)2.99897143
66detection of biotic stimulus (GO:0009595)2.99505858
67telomere maintenance via semi-conservative replication (GO:0032201)2.99482154
68antigen processing and presentation via MHC class Ib (GO:0002475)2.98832160
69megakaryocyte development (GO:0035855)2.98464737
70positive regulation of antigen processing and presentation (GO:0002579)2.97424427
71regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.96670619
72regulation of dendritic cell antigen processing and presentation (GO:0002604)2.96662368
73mast cell activation involved in immune response (GO:0002279)2.96270510
74mast cell degranulation (GO:0043303)2.96270510
75T cell homeostasis (GO:0043029)2.95956585
76DNA unwinding involved in DNA replication (GO:0006268)2.95717643
77regulation of mast cell activation (GO:0033003)2.95357069
78B cell homeostasis (GO:0001782)2.95162695
79lipopolysaccharide-mediated signaling pathway (GO:0031663)2.95161594
80T-helper 1 type immune response (GO:0042088)2.94792453
81regulation of gamma-delta T cell differentiation (GO:0045586)2.93364751
82regulation of mast cell degranulation (GO:0043304)2.91986141
83germinal center formation (GO:0002467)2.91580947
84actin nucleation (GO:0045010)2.91485878
85negative T cell selection (GO:0043383)2.91453711
86negative regulation of granulocyte differentiation (GO:0030853)2.89223550
87negative regulation of leukocyte mediated immunity (GO:0002704)2.89064515
88DNA strand elongation involved in DNA replication (GO:0006271)2.88340898
89lymphocyte homeostasis (GO:0002260)2.87179757
90negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.86231590
91granulocyte activation (GO:0036230)2.85564285
92neutrophil mediated immunity (GO:0002446)2.83464973
93telomere maintenance via recombination (GO:0000722)2.81544047
94positive regulation of type 2 immune response (GO:0002830)2.81068596
95pinocytosis (GO:0006907)2.81026348
96negative regulation of T-helper cell differentiation (GO:0045623)2.80746732
97negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.80746732
98positive regulation of mast cell activation involved in immune response (GO:0033008)2.80554269
99positive regulation of mast cell degranulation (GO:0043306)2.80554269
100response to interferon-beta (GO:0035456)2.80115439
101regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.79538617
102mature B cell differentiation (GO:0002335)2.79122863
103regulation of gamma-delta T cell activation (GO:0046643)2.78588364
104DNA strand elongation (GO:0022616)2.77972055
105regulation of T-helper 2 cell differentiation (GO:0045628)2.77480172
106positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.76434100
107mitotic recombination (GO:0006312)2.75925632
108positive regulation of alpha-beta T cell proliferation (GO:0046641)2.75260452
109T cell selection (GO:0045058)2.75059643
110positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.73849462
111regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.73708630
112negative regulation of B cell proliferation (GO:0030889)2.72524331
113DNA topological change (GO:0006265)2.71967697
114regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.71735754
115positive regulation of mast cell activation (GO:0033005)2.70469888
116leukocyte aggregation (GO:0070486)2.69515966
117mature B cell differentiation involved in immune response (GO:0002313)2.69368452
118viral transcription (GO:0019083)2.68658202
119regulation of erythrocyte differentiation (GO:0045646)2.68267486
120regulation of mast cell activation involved in immune response (GO:0033006)2.67608976
121positive regulation of macrophage differentiation (GO:0045651)2.67209046
122leukocyte degranulation (GO:0043299)2.66733351
123cellular response to interferon-beta (GO:0035458)2.62930489
124leukocyte homeostasis (GO:0001776)2.60248579
125positive regulation of granulocyte differentiation (GO:0030854)2.58101892
126regulation of interleukin-12 biosynthetic process (GO:0045075)2.57464235
127response to host immune response (GO:0052572)2.55523849
128response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.55523849
129leukocyte mediated cytotoxicity (GO:0001909)2.54092507
130myeloid dendritic cell differentiation (GO:0043011)2.53961384
131interferon-gamma-mediated signaling pathway (GO:0060333)2.53663239
132myeloid leukocyte activation (GO:0002274)2.53534093
133translational termination (GO:0006415)2.52012422
134response to type I interferon (GO:0034340)2.50161202
135cellular response to type I interferon (GO:0071357)2.49555002
136type I interferon signaling pathway (GO:0060337)2.49555002
137regulation of antigen processing and presentation (GO:0002577)2.48437329
138positive regulation of interferon-beta production (GO:0032728)2.47151128
139response to fungus (GO:0009620)2.45326465
140regulation of granulocyte differentiation (GO:0030852)2.44614402
141response to muramyl dipeptide (GO:0032495)2.44388691
142natural killer cell differentiation (GO:0001779)2.43186385
143B cell proliferation (GO:0042100)2.39719173

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.52394763
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.30318536
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.97220890
4* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.46835405
5* IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.44228620
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.13336918
7SCL_19346495_ChIP-Seq_HPC-7_Human3.13207488
8* SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.13150002
9BP1_19119308_ChIP-ChIP_Hs578T_Human3.06028971
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.79768897
11* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.74923963
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.73695359
13IRF8_27001747_Chip-Seq_BMDM_Mouse2.70264544
14MYC_22102868_ChIP-Seq_BL_Human2.66873259
15VDR_21846776_ChIP-Seq_THP-1_Human2.59180785
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.51467660
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.46039514
18* SPI1_23547873_ChIP-Seq_NB4_Human2.42254971
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.37092803
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.36500372
21EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.36236893
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.35507971
23FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.25315583
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.25007208
25FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.24000907
26ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.18210209
27TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.08848658
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.03585190
29MYB_26560356_Chip-Seq_TH2_Human1.98767471
30VDR_24763502_ChIP-Seq_THP-1_Human1.97912443
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.96859799
32BRD4_27068464_Chip-Seq_AML-cells_Mouse1.96103862
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.95218942
34SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.95193197
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.92358469
36SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.88749073
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.84863726
38STAT4_19710469_ChIP-ChIP_TH1__Mouse1.84089509
39MAF_26560356_Chip-Seq_TH1_Human1.82617216
40GATA1_22025678_ChIP-Seq_K562_Human1.80605590
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.79549348
42MYB_26560356_Chip-Seq_TH1_Human1.78546904
43GATA1_19941826_ChIP-Seq_K562_Human1.76675974
44MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.72337694
45ERG_20887958_ChIP-Seq_HPC-7_Mouse1.65986571
46STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.63947902
47CIITA_25753668_ChIP-Seq_RAJI_Human1.63491023
48LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.61105527
49MYC_18555785_ChIP-Seq_MESCs_Mouse1.60590772
50UTX_26944678_Chip-Seq_JUKART_Human1.59930341
51* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.59329692
52GATA1_22383799_ChIP-Seq_G1ME_Mouse1.56349540
53GATA2_22383799_ChIP-Seq_G1ME_Mouse1.53152852
54E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.50635141
55LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.50511069
56RUNX_20019798_ChIP-Seq_JUKART_Human1.49239630
57TCF7_22412390_ChIP-Seq_EML_Mouse1.48423755
58VDR_23849224_ChIP-Seq_CD4+_Human1.47222117
59* SPI1_23127762_ChIP-Seq_K562_Human1.45632817
60VDR_24787735_ChIP-Seq_THP-1_Human1.45283790
61GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.40131103
62FOXP3_21729870_ChIP-Seq_TREG_Human1.40001340
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.37343033
64NCOR1_26117541_ChIP-Seq_K562_Human1.35943247
65EST1_17652178_ChIP-ChIP_JURKAT_Human1.35121194
66GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34010483
67E2F1_21310950_ChIP-Seq_MCF-7_Human1.33901695
68TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.30016372
69KDM2B_26808549_Chip-Seq_SUP-B15_Human1.29125006
70* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28800421
71GATA2_19941826_ChIP-Seq_K562_Human1.27173529
72PU_27001747_Chip-Seq_BMDM_Mouse1.26730534
73KDM2B_26808549_Chip-Seq_DND41_Human1.23061163
74* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.20411746
75FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.19633641
76GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.19369609
77MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18400216
78NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.17894837
79PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17784717
80GABP_17652178_ChIP-ChIP_JURKAT_Human1.16678366
81CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16090771
82GATA1_19941827_ChIP-Seq_MEL_Mouse1.14743897
83Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.12054423
84KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.11807517
85MAF_26560356_Chip-Seq_TH2_Human1.09683720
86PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09473664
87NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.08977195
88* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.08249586
89XRN2_22483619_ChIP-Seq_HELA_Human1.08136129
90CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.07974271
91MYC_19079543_ChIP-ChIP_MESCs_Mouse1.07212369
92* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05117664
93ETS1_20019798_ChIP-Seq_JURKAT_Human1.05075014
94GATA3_27048872_Chip-Seq_THYMUS_Human1.04273047
95HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.04028550
96TFEB_21752829_ChIP-Seq_HELA_Human1.03619366
97CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02684654
98ELK3_25401928_ChIP-Seq_HUVEC_Human1.02619693
99PU.1_20513432_ChIP-Seq_Bcells_Mouse1.02390574
100RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02185673
101BCL6_27268052_Chip-Seq_Bcells_Human1.01265197
102NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.01102035
103CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00715412
104* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.00189194
105ELK1_19687146_ChIP-ChIP_HELA_Human0.99909555
106JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.99773437
107GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99633892
108ELF1_20517297_ChIP-Seq_JURKAT_Human0.98110399
109SRF_21415370_ChIP-Seq_HL-1_Mouse0.94756401
110IKZF1_21737484_ChIP-ChIP_HCT116_Human0.94045027
111NELFA_20434984_ChIP-Seq_ESCs_Mouse0.94002914
112BCOR_27268052_Chip-Seq_Bcells_Human0.93135880
113VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.91669286
114SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91004381
115* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90381124
116PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90056296
117CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89946439
118GATA3_26560356_Chip-Seq_TH2_Human0.89928987
119KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.89642844
120CREB1_15753290_ChIP-ChIP_HEK293T_Human0.89458066
121STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.89225639
122ETS1_22383799_ChIP-Seq_G1ME_Mouse0.88215974
123KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.88152565
124LXR_22292898_ChIP-Seq_THP-1_Human0.87920980
125PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87465204
126SPI1_20517297_ChIP-Seq_HL60_Human0.87325213

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.66881328
2MP0002396_abnormal_hematopoietic_system3.30831218
3* MP0001800_abnormal_humoral_immune3.11213866
4MP0003436_decreased_susceptibility_to2.92259002
5* MP0002452_abnormal_antigen_presenting2.88369430
6MP0000685_abnormal_immune_system2.78298188
7* MP0005000_abnormal_immune_tolerance2.77894088
8* MP0005387_immune_system_phenotype2.71055515
9* MP0001790_abnormal_immune_system2.71055515
10* MP0002419_abnormal_innate_immunity2.70625898
11MP0009785_altered_susceptibility_to2.68744898
12MP0005671_abnormal_response_to2.64819161
13MP0002148_abnormal_hypersensitivity_rea2.61931752
14MP0005025_abnormal_response_to2.60249035
15* MP0002723_abnormal_immune_serum2.59024795
16* MP0002420_abnormal_adaptive_immunity2.57771253
17* MP0001819_abnormal_immune_cell2.54944673
18* MP0005464_abnormal_platelet_physiology2.52227056
19MP0003303_peritoneal_inflammation2.51744556
20* MP0002398_abnormal_bone_marrow2.45752876
21MP0004808_abnormal_hematopoietic_stem2.23269902
22MP0000465_gastrointestinal_hemorrhage2.21020685
23* MP0000716_abnormal_immune_system2.19790234
24* MP0000689_abnormal_spleen_morphology2.18959544
25MP0001545_abnormal_hematopoietic_system2.09058012
26MP0005397_hematopoietic_system_phenotyp2.09058012
27* MP0002722_abnormal_immune_system1.98954181
28MP0001853_heart_inflammation1.98785270
29MP0005058_abnormal_lysosome_morphology1.96139669
30* MP0002429_abnormal_blood_cell1.95922409
31MP0002405_respiratory_system_inflammati1.92626841
32MP0002166_altered_tumor_susceptibility1.92302582
33MP0008057_abnormal_DNA_replication1.92256331
34MP0010094_abnormal_chromosome_stability1.91098909
35MP0005174_abnormal_tail_pigmentation1.83050283
36MP0003693_abnormal_embryo_hatching1.82616436
37MP0003724_increased_susceptibility_to1.72203512
38MP0003763_abnormal_thymus_physiology1.69656099
39* MP0001845_abnormal_inflammatory_respons1.68384255
40MP0005451_abnormal_body_composition1.67182356
41MP0000490_abnormal_crypts_of1.65315435
42* MP0010155_abnormal_intestine_physiology1.61388266
43MP0009333_abnormal_splenocyte_physiolog1.61359310
44MP0002006_tumorigenesis1.61328436
45MP0009278_abnormal_bone_marrow1.60160008
46MP0003172_abnormal_lysosome_physiology1.57852270
47MP0006082_CNS_inflammation1.55958491
48MP0003191_abnormal_cellular_cholesterol1.51077886
49MP0003183_abnormal_peptide_metabolism1.50234360
50MP0003077_abnormal_cell_cycle1.44073184
51MP0003300_gastrointestinal_ulcer1.43247019
52MP0003656_abnormal_erythrocyte_physiolo1.40676475
53MP0008469_abnormal_protein_level1.40459372
54MP0000703_abnormal_thymus_morphology1.39003423
55MP0008260_abnormal_autophagy1.38878703
56MP0001873_stomach_inflammation1.38383297
57MP0003111_abnormal_nucleus_morphology1.36648255
58MP0001533_abnormal_skeleton_physiology1.34040045
59MP0010307_abnormal_tumor_latency1.31720402
60MP0004947_skin_inflammation1.29720522
61MP0008007_abnormal_cellular_replicative1.29475325
62MP0006054_spinal_hemorrhage1.25394094
63MP0003806_abnormal_nucleotide_metabolis1.22218125
64MP0009840_abnormal_foam_cell1.21253946
65MP0005310_abnormal_salivary_gland1.19943783
66MP0008058_abnormal_DNA_repair1.16419641
67MP0002019_abnormal_tumor_incidence1.15632746
68MP0003866_abnormal_defecation1.15294676
69MP0008004_abnormal_stomach_pH1.11411943
70MP0005075_abnormal_melanosome_morpholog1.10697735
71MP0009764_decreased_sensitivity_to1.10528641
72MP0000343_altered_response_to1.09748813
73MP0004510_myositis1.09108245
74MP0002095_abnormal_skin_pigmentation1.07887094
75MP0002009_preneoplasia1.07084969
76MP0000858_altered_metastatic_potential1.04361158
77MP0002138_abnormal_hepatobiliary_system1.04118565
78MP0004147_increased_porphyrin_level0.97149785
79MP0004957_abnormal_blastocyst_morpholog0.95786247
80MP0002132_abnormal_respiratory_system0.93864639
81MP0001986_abnormal_taste_sensitivity0.93836173
82MP0004883_abnormal_blood_vessel0.91752617
83MP0000015_abnormal_ear_pigmentation0.91017903
84MP0000604_amyloidosis0.90600179
85MP0003448_altered_tumor_morphology0.88524216
86MP0000569_abnormal_digit_pigmentation0.86860143
87MP0000313_abnormal_cell_death0.86579713
88MP0009763_increased_sensitivity_to0.80897595
89MP0002933_joint_inflammation0.80486214
90MP0009765_abnormal_xenobiotic_induced0.79424938
91MP0003075_altered_response_to0.75417150
92MP0003828_pulmonary_edema0.69919895
93MP0010352_gastrointestinal_tract_polyps0.69841317
94MP0003690_abnormal_glial_cell0.69540325
95MP0002928_abnormal_bile_duct0.67689406
96MP0001663_abnormal_digestive_system0.65793751
97MP0005164_abnormal_response_to0.63917400
98MP0000371_diluted_coat_color0.63634511
99MP0008874_decreased_physiological_sensi0.63630300
100MP0000249_abnormal_blood_vessel0.63385079
101MP0004381_abnormal_hair_follicle0.62401019
102MP0005166_decreased_susceptibility_to0.62308304
103MP0003566_abnormal_cell_adhesion0.62029265
104MP0001915_intracranial_hemorrhage0.60824070
105MP0000598_abnormal_liver_morphology0.60367409
106MP0000350_abnormal_cell_proliferation0.60239199
107MP0003943_abnormal_hepatobiliary_system0.59533738
108MP0000609_abnormal_liver_physiology0.59079182
109MP0006036_abnormal_mitochondrial_physio0.58627117
110MP0001851_eye_inflammation0.57867136
111MP0008873_increased_physiological_sensi0.57743213
112MP0004782_abnormal_surfactant_physiolog0.55693256
113MP0003795_abnormal_bone_structure0.55589941
114MP0005621_abnormal_cell_physiology0.54880212
115MP0005390_skeleton_phenotype0.54808022
116MP0002998_abnormal_bone_remodeling0.54271973
117MP0002877_abnormal_melanocyte_morpholog0.54216258
118MP0002139_abnormal_hepatobiliary_system0.52616655
119MP0003221_abnormal_cardiomyocyte_apopto0.52230262
120MP0005083_abnormal_biliary_tract0.49399787
121MP0009115_abnormal_fat_cell0.48586495
122MP0005535_abnormal_body_temperature0.47328909
123MP0002693_abnormal_pancreas_physiology0.45262584
124MP0006035_abnormal_mitochondrial_morpho0.45218697

Predicted human phenotypes

RankGene SetZ-score
1* Recurrent abscess formation (HP:0002722)5.32965448
2* Recurrent bacterial skin infections (HP:0005406)4.70385092
3* Cellulitis (HP:0100658)4.66649870
4IgM deficiency (HP:0002850)4.64302161
5Eczematoid dermatitis (HP:0000976)4.61784642
6* Agammaglobulinemia (HP:0004432)4.43403428
7Petechiae (HP:0000967)4.42849293
8* Recurrent viral infections (HP:0004429)4.09192948
9Recurrent fungal infections (HP:0002841)3.85703639
10Thrombocytosis (HP:0001894)3.84727959
11Prolonged bleeding time (HP:0003010)3.83205775
12* Meningitis (HP:0001287)3.73984177
13Stomatitis (HP:0010280)3.72021129
14Recurrent bronchitis (HP:0002837)3.67114108
15Colitis (HP:0002583)3.56781606
16Recurrent gram-negative bacterial infections (HP:0005420)3.55254783
17Abnormal delayed hypersensitivity skin test (HP:0002963)3.51810807
18Mediastinal lymphadenopathy (HP:0100721)3.47492385
19Abnormality of macrophages (HP:0004311)3.37973701
20Inflammation of the large intestine (HP:0002037)3.35361429
21Myositis (HP:0100614)3.33257882
22Obstructive lung disease (HP:0006536)3.31064226
23Chronic obstructive pulmonary disease (HP:0006510)3.31064226
24* Recurrent skin infections (HP:0001581)3.27189097
25Gastrointestinal inflammation (HP:0004386)3.26402066
26Elevated erythrocyte sedimentation rate (HP:0003565)3.26121400
27Gastrointestinal stroma tumor (HP:0100723)3.21975889
28Recurrent pneumonia (HP:0006532)3.05889294
29B lymphocytopenia (HP:0010976)3.03320031
30Abnormality of B cell number (HP:0010975)3.03320031
31* Chronic otitis media (HP:0000389)3.00637157
32* Osteomyelitis (HP:0002754)2.99111854
33Vacuolated lymphocytes (HP:0001922)2.98863881
34Chronic mucocutaneous candidiasis (HP:0002728)2.98626544
35Recurrent cutaneous fungal infections (HP:0011370)2.98626544
36Abnormal platelet volume (HP:0011876)2.96461131
37Vasculitis (HP:0002633)2.95170582
38Gastrointestinal infarctions (HP:0005244)2.93184182
39Abnormality of T cell physiology (HP:0011840)2.90518387
40Verrucae (HP:0200043)2.90309475
41Papilloma (HP:0012740)2.90309475
42Recurrent lower respiratory tract infections (HP:0002783)2.89538590
43Increased neuronal autofluorescent lipopigment (HP:0002074)2.88418418
44Increased cerebral lipofuscin (HP:0011813)2.88089592
45Lymphopenia (HP:0001888)2.86834176
46Abnormality of cells of the lymphoid lineage (HP:0012140)2.85028928
47Chest pain (HP:0100749)2.84750034
48Epistaxis (HP:0000421)2.82851485
49* Panhypogammaglobulinemia (HP:0003139)2.81605023
50Thyroiditis (HP:0100646)2.73209881
51Reticulocytopenia (HP:0001896)2.68857422
52Abnormal platelet function (HP:0011869)2.65534790
53Impaired platelet aggregation (HP:0003540)2.65534790
54Spontaneous hematomas (HP:0007420)2.63501424
55T lymphocytopenia (HP:0005403)2.62367581
56Abnormality of glycolipid metabolism (HP:0010969)2.61376250
57Abnormality of liposaccharide metabolism (HP:0010968)2.61376250
58Abnormality of glycosphingolipid metabolism (HP:0004343)2.61376250
59Recurrent sinusitis (HP:0011108)2.60719348
60Keratoconjunctivitis sicca (HP:0001097)2.59812044
61Abnormal number of erythroid precursors (HP:0012131)2.58833153
62Purpura (HP:0000979)2.58243641
63Chronic sinusitis (HP:0011109)2.58226707
64Autoimmune thrombocytopenia (HP:0001973)2.56722457
65Autoimmune hemolytic anemia (HP:0001890)2.56113944
66Systemic lupus erythematosus (HP:0002725)2.56063968
67Gingival bleeding (HP:0000225)2.53007451
68Abnormality of T cell number (HP:0011839)2.52771103
69Abnormality of cells of the erythroid lineage (HP:0012130)2.52745996
70Nasal polyposis (HP:0100582)2.51189389
71Increased mean platelet volume (HP:0011877)2.51107061
72Increased serum ferritin (HP:0003281)2.49909527
73Hemoptysis (HP:0002105)2.45435832
74Pustule (HP:0200039)2.44085876
75Lymphoma (HP:0002665)2.42594315
76Abnormality of T cells (HP:0002843)2.42346924
77Interstitial pulmonary disease (HP:0006530)2.41874080
78IgG deficiency (HP:0004315)2.40202358
79Abnormality of iron homeostasis (HP:0011031)2.37366146
80Increased IgM level (HP:0003496)2.36352907
81Keratoconjunctivitis (HP:0001096)2.36198611
82Aplastic anemia (HP:0001915)2.36012656
83Granulocytopenia (HP:0001913)2.35999797
84Amaurosis fugax (HP:0100576)2.35509927
85Gingivitis (HP:0000230)2.35212988
86Hepatosplenomegaly (HP:0001433)2.34042671
87Agnosia (HP:0010524)2.32123435
88Periodontitis (HP:0000704)2.31522104
89IgA deficiency (HP:0002720)2.30526589
90* Sepsis (HP:0100806)2.28383277
91Leukocytosis (HP:0001974)2.28303609
92Eosinophilia (HP:0001880)2.27415354
93Abnormality of the nasal mucosa (HP:0000433)2.27023362
94Orchitis (HP:0100796)2.25664450
95Hypertensive crisis (HP:0100735)2.25024533
96Neutropenia (HP:0001875)2.24059933
97Acute myeloid leukemia (HP:0004808)2.18292873
98Myelodysplasia (HP:0002863)2.17386027
99Hypergammaglobulinemia (HP:0010702)2.15789109
100Pulmonary embolism (HP:0002204)2.14425722
101* Encephalitis (HP:0002383)2.13628362
102Optic neuritis (HP:0100653)2.12704771
103Retrobulbar optic neuritis (HP:0100654)2.12704771
104Urticaria (HP:0001025)2.12184447
105Loss of speech (HP:0002371)2.11676996
106* Skin rash (HP:0000988)2.10126865
107Reduced antithrombin III activity (HP:0001976)2.09533885
108Polycythemia (HP:0001901)2.08634918
109Thoracic kyphosis (HP:0002942)2.07981311
110Leukopenia (HP:0001882)2.06387699
111Abnormality of the fingertips (HP:0001211)2.05597514
112Emphysema (HP:0002097)2.04682408
113* Skin ulcer (HP:0200042)2.03460986
114Abnormality of transition element cation homeostasis (HP:0011030)2.02444154
115Dysostosis multiplex (HP:0000943)2.01569942
116Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.01520759
117Episodic fever (HP:0001954)2.00860049
118Abnormality of the thoracic spine (HP:0100711)2.00771659
119Abnormality of the pleura (HP:0002103)2.00732444
120Pulmonary infiltrates (HP:0002113)2.00341976
121* Abnormality of the prostate (HP:0008775)1.99807055
122Disinhibition (HP:0000734)1.98592797
123Abnormality of the heme biosynthetic pathway (HP:0010472)1.97921119
124Fatigue (HP:0012378)1.97602600
125Restrictive lung disease (HP:0002091)1.96398548
126Bronchitis (HP:0012387)1.95945759
127Arterial thrombosis (HP:0004420)1.93392090
128Increased IgE level (HP:0003212)1.92475621

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.83763284
2BLK3.29453573
3KIT3.12865959
4IRAK43.00263766
5PRPF4B2.73879435
6CSF1R2.56531246
7MAP3K142.56208859
8EEF2K2.49781724
9* BTK2.37123461
10RIPK42.11708325
11TYK22.09693790
12* SYK2.06890894
13BMPR22.02622009
14TBK11.89065668
15ERN11.82165622
16TAOK31.76234792
17STK101.70659006
18CLK11.67367936
19ZAP701.65248387
20FES1.63372017
21GRK61.62827183
22PIM21.61683034
23MAP2K31.57195310
24MAP3K101.53520676
25JAK31.53213677
26* TEC1.52148703
27IKBKB1.50302811
28TGFBR21.50068018
29IRAK31.49344796
30FLT31.47275975
31* LYN1.45991642
32FGR1.45067404
33CDC71.42714211
34LRRK21.37749644
35CCNB11.34252799
36HCK1.33123955
37PIM11.32848255
38WEE11.25902150
39MATK1.24003481
40IKBKE1.23207894
41NEK21.19001590
42EIF2AK11.16343064
43TXK1.11620863
44STK41.07924378
45RPS6KA41.05435603
46EIF2AK31.01749975
47NME21.01388964
48RPS6KB21.01214653
49MAP3K111.00857834
50JAK10.98819788
51* LCK0.98335480
52TAOK20.97884798
53STK160.96863473
54SCYL20.94575853
55PKN20.92345583
56MAP3K10.91104085
57BRSK20.90375037
58SMG10.87672795
59CDK40.86769182
60CSK0.86366376
61ATR0.82932142
62TESK20.82677577
63MAP3K130.80898604
64BUB10.79801299
65IRAK10.78258086
66PDK10.76664149
67SIK20.75940863
68TGFBR10.75321946
69VRK10.75005875
70CHUK0.72515374
71CDK60.71431218
72MAPK40.71007135
73TRPM70.69859065
74MAPK120.69098673
75KSR20.67636770
76JAK20.65233667
77MAP3K30.64217009
78IRAK20.61465747
79PDPK10.60092412
80ACVR1B0.59654997
81CDK120.59341439
82NEK90.59190301
83MAP3K50.58304996
84MAP3K80.57502420
85TAOK10.56808383
86DYRK30.53866331
87RPS6KA60.52294653
88MKNK10.49837946
89MAPKAPK50.49271741
90* ITK0.49191474
91MAPK110.47965441
92TNK20.47846235
93CDC42BPA0.47591038
94AURKB0.47496651
95MAPK70.47430182
96PASK0.47341828
97SIK30.47333550
98TRIB30.47135231
99MAPKAPK20.46286862
100MAP3K60.46218825
101PRKCD0.45335172
102EPHB10.45026010
103PAK40.44777243
104YES10.44633220
105PIK3CG0.44498484
106HIPK20.44151968
107RAF10.43462290
108FYN0.43008784
109RPS6KC10.42696719
110RPS6KL10.42696719
111CDK70.42447153
112PRKCQ0.41720426
113EIF2AK20.41266874
114STK240.40895675
115MARK30.40873616
116ALK0.40839072
117TSSK60.40681343
118BMX0.39814004
119CAMK1D0.38150002
120GRK70.37347815
121BRSK10.36688949
122MARK20.36597169
123FGFR30.34434920
124CDK190.33490024
125MAPKAPK30.33374992
126TLK10.33345604
127MAP3K120.33085802
128EGFR0.32297230
129* ABL10.32244024
130MAPK30.30619083
131BCKDK0.25080875

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.29976612
2Autoimmune thyroid disease_Homo sapiens_hsa053203.08297753
3* B cell receptor signaling pathway_Homo sapiens_hsa046622.99159643
4* Primary immunodeficiency_Homo sapiens_hsa053402.88737506
5Base excision repair_Homo sapiens_hsa034102.65270517
6Leishmaniasis_Homo sapiens_hsa051402.61911022
7Type I diabetes mellitus_Homo sapiens_hsa049402.50342424
8Mismatch repair_Homo sapiens_hsa034302.26272082
9Hematopoietic cell lineage_Homo sapiens_hsa046402.11032811
10* NF-kappa B signaling pathway_Homo sapiens_hsa040642.08023842
11Antigen processing and presentation_Homo sapiens_hsa046122.04539075
12* Osteoclast differentiation_Homo sapiens_hsa043802.00057110
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.99457590
14Ribosome_Homo sapiens_hsa030101.98689827
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.90296020
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.89426207
17Measles_Homo sapiens_hsa051621.86098033
18Staphylococcus aureus infection_Homo sapiens_hsa051501.85051620
19Homologous recombination_Homo sapiens_hsa034401.77740442
20Herpes simplex infection_Homo sapiens_hsa051681.72625872
21Non-homologous end-joining_Homo sapiens_hsa034501.68594035
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.68453159
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.66394200
24Legionellosis_Homo sapiens_hsa051341.65898888
25Other glycan degradation_Homo sapiens_hsa005111.60484640
26Glycosaminoglycan degradation_Homo sapiens_hsa005311.59246720
27Pertussis_Homo sapiens_hsa051331.55899536
28Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.54517235
29Tuberculosis_Homo sapiens_hsa051521.53284291
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.44936430
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.41501309
32Shigellosis_Homo sapiens_hsa051311.35256826
33* Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.32858919
34Influenza A_Homo sapiens_hsa051641.32045954
35Spliceosome_Homo sapiens_hsa030401.28764511
36Apoptosis_Homo sapiens_hsa042101.27547801
37Toxoplasmosis_Homo sapiens_hsa051451.26098864
38Nucleotide excision repair_Homo sapiens_hsa034201.21804749
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.21381578
40Hepatitis B_Homo sapiens_hsa051611.21148702
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.20445686
42Acute myeloid leukemia_Homo sapiens_hsa052211.20261686
43Malaria_Homo sapiens_hsa051441.19434670
44Cell cycle_Homo sapiens_hsa041101.19354429
45Asthma_Homo sapiens_hsa053101.15000143
46Transcriptional misregulation in cancer_Homo sapiens_hsa052021.08317314
47* Platelet activation_Homo sapiens_hsa046111.07432706
48Allograft rejection_Homo sapiens_hsa053301.07413019
49Epstein-Barr virus infection_Homo sapiens_hsa051691.07011509
50Chemokine signaling pathway_Homo sapiens_hsa040621.06893113
51Pyrimidine metabolism_Homo sapiens_hsa002401.06032814
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.05163175
53Lysosome_Homo sapiens_hsa041421.03760589
54Chronic myeloid leukemia_Homo sapiens_hsa052201.03735384
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.01187027
56Fanconi anemia pathway_Homo sapiens_hsa034600.95509420
57One carbon pool by folate_Homo sapiens_hsa006700.93786502
58Salmonella infection_Homo sapiens_hsa051320.92704181
59Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.91136362
60Caffeine metabolism_Homo sapiens_hsa002320.90378908
61p53 signaling pathway_Homo sapiens_hsa041150.89594395
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.87835857
63Pancreatic cancer_Homo sapiens_hsa052120.86616148
64TNF signaling pathway_Homo sapiens_hsa046680.86519968
65Pentose phosphate pathway_Homo sapiens_hsa000300.85436619
66Viral carcinogenesis_Homo sapiens_hsa052030.81016174
67N-Glycan biosynthesis_Homo sapiens_hsa005100.80380911
68T cell receptor signaling pathway_Homo sapiens_hsa046600.80108623
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79817647
70Graft-versus-host disease_Homo sapiens_hsa053320.77010113
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76470105
72RNA degradation_Homo sapiens_hsa030180.75477702
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74755437
74RNA transport_Homo sapiens_hsa030130.73085912
75Proteasome_Homo sapiens_hsa030500.71737183
76RNA polymerase_Homo sapiens_hsa030200.66795074
77Non-small cell lung cancer_Homo sapiens_hsa052230.66673030
78Renin-angiotensin system_Homo sapiens_hsa046140.65911662
79Phagosome_Homo sapiens_hsa041450.64550710
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63798390
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63337987
82Hepatitis C_Homo sapiens_hsa051600.62267068
83Small cell lung cancer_Homo sapiens_hsa052220.61909805
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61734592
85Viral myocarditis_Homo sapiens_hsa054160.60755477
86Systemic lupus erythematosus_Homo sapiens_hsa053220.60723897
87VEGF signaling pathway_Homo sapiens_hsa043700.59185960
88African trypanosomiasis_Homo sapiens_hsa051430.57359178
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.57292924
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56688226
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.55717430
92Prolactin signaling pathway_Homo sapiens_hsa049170.55376481
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55341095
94HTLV-I infection_Homo sapiens_hsa051660.55238872
95AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50700912
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47154832
97Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.46498753
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41820770
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40369827
100Renal cell carcinoma_Homo sapiens_hsa052110.38966926
101Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.38727967
102ABC transporters_Homo sapiens_hsa020100.38507656
103Drug metabolism - other enzymes_Homo sapiens_hsa009830.38396388
104Rheumatoid arthritis_Homo sapiens_hsa053230.38246947
105Basal transcription factors_Homo sapiens_hsa030220.37348561
106Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36542649
107HIF-1 signaling pathway_Homo sapiens_hsa040660.34905298
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.32699736
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.32471712
110Purine metabolism_Homo sapiens_hsa002300.31270048
111Colorectal cancer_Homo sapiens_hsa052100.31232061
112Phospholipase D signaling pathway_Homo sapiens_hsa040720.30295847
113Endocytosis_Homo sapiens_hsa041440.29872534
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29309850
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.28898653
116mTOR signaling pathway_Homo sapiens_hsa041500.28390504
117Inositol phosphate metabolism_Homo sapiens_hsa005620.25618384
118Choline metabolism in cancer_Homo sapiens_hsa052310.24118719
119Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.23564671
120Type II diabetes mellitus_Homo sapiens_hsa049300.22973413
121GnRH signaling pathway_Homo sapiens_hsa049120.21418470
122Bladder cancer_Homo sapiens_hsa052190.20141041
123Amoebiasis_Homo sapiens_hsa051460.19387526
124Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.18021814
125FoxO signaling pathway_Homo sapiens_hsa040680.17666084
126Insulin resistance_Homo sapiens_hsa049310.16353522
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.16072734
128MAPK signaling pathway_Homo sapiens_hsa040100.16003816
129Dorso-ventral axis formation_Homo sapiens_hsa043200.13453224
130Notch signaling pathway_Homo sapiens_hsa043300.12767366

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