BTN2A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Butyrophilin is the major protein associated with fat droplets in the milk. This gene is a member of the BTN2 subfamily of genes, which encode proteins belonging to the butyrophilin protein family. The gene is located in a cluster on chromosome 6, consisting of seven genes belonging to the expanding B7/butyrophilin-like group, a subset of the immunoglobulin gene superfamily. The encoded protein is a type I receptor glycoprotein involved in lipid, fatty-acid and sterol metabolism. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tongue development (GO:0043586)6.26088187
2potassium ion export (GO:0071435)6.06362612
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.80043703
4membrane repolarization during action potential (GO:0086011)5.71893042
5antigen processing and presentation of endogenous antigen (GO:0019883)5.66874968
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.62034250
7negative regulation of cell killing (GO:0031342)5.15385799
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.15385799
9positive regulation of gamma-delta T cell activation (GO:0046645)5.14415084
10modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.95300502
11positive regulation by organism of defense response of other organism involved in symbiotic interact4.95300502
12modulation by symbiont of host immune response (GO:0052553)4.95300502
13positive regulation by symbiont of host defense response (GO:0052509)4.95300502
14modulation by symbiont of host defense response (GO:0052031)4.95300502
15modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.95300502
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.82323401
17type I interferon signaling pathway (GO:0060337)4.65514989
18cellular response to type I interferon (GO:0071357)4.65514989
19response to type I interferon (GO:0034340)4.61570850
20maturation of 5.8S rRNA (GO:0000460)4.60225345
21regulation of B cell receptor signaling pathway (GO:0050855)4.35421547
22mitotic metaphase plate congression (GO:0007080)4.33094895
23detection of other organism (GO:0098543)4.27145747
24regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.25248930
25immunoglobulin mediated immune response (GO:0016064)4.21620537
26detection of bacterium (GO:0016045)4.17878267
27T cell migration (GO:0072678)4.15380378
28mitotic sister chromatid segregation (GO:0000070)4.15291948
29regulation of hippo signaling (GO:0035330)4.04770121
30regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.01261858
31negative thymic T cell selection (GO:0045060)4.00702835
32paraxial mesoderm development (GO:0048339)3.98360868
33interferon-gamma-mediated signaling pathway (GO:0060333)3.97412657
34detection of molecule of bacterial origin (GO:0032490)3.94092867
35notochord development (GO:0030903)3.93786984
36response to muramyl dipeptide (GO:0032495)3.87240168
37membrane repolarization (GO:0086009)3.85282175
38vitamin transmembrane transport (GO:0035461)3.83384387
39detection of external biotic stimulus (GO:0098581)3.81897135
40regulation of dendritic cell antigen processing and presentation (GO:0002604)3.81256451
41B cell mediated immunity (GO:0019724)3.80126228
42macrophage activation involved in immune response (GO:0002281)3.78482392
43B cell receptor signaling pathway (GO:0050853)3.76687438
44negative T cell selection (GO:0043383)3.73529136
45potassium ion import (GO:0010107)3.71940402
46regulation of interferon-beta biosynthetic process (GO:0045357)3.66293902
47peptidyl-arginine omega-N-methylation (GO:0035247)3.63375295
48ventricular cardiac muscle cell action potential (GO:0086005)3.63141482
49response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.60044967
50response to host immune response (GO:0052572)3.60044967
51peptidyl-arginine N-methylation (GO:0035246)3.59290318
52peptidyl-arginine methylation (GO:0018216)3.59290318
53negative regulation of interleukin-12 production (GO:0032695)3.59176193
54sister chromatid segregation (GO:0000819)3.55062169
55positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.54349547
56regulation of heart rate by cardiac conduction (GO:0086091)3.54076572
57glycerophospholipid catabolic process (GO:0046475)3.51314976
58response to peptidoglycan (GO:0032494)3.50776363
59histone H2A monoubiquitination (GO:0035518)3.50423541
60NIK/NF-kappaB signaling (GO:0038061)3.49134705
61positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.46746433
62response to host (GO:0075136)3.44245312
63response to host defenses (GO:0052200)3.44245312
64response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.44245312
65antigen processing and presentation via MHC class Ib (GO:0002475)3.43331153
66regulation of meiosis I (GO:0060631)3.39817318
67regulation of spindle organization (GO:0090224)3.38651278
68response to interferon-alpha (GO:0035455)3.38376463
69positive regulation of interferon-alpha production (GO:0032727)3.37901159
70metaphase plate congression (GO:0051310)3.37582286
71positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.36296629
72detection of biotic stimulus (GO:0009595)3.34764360
73microtubule depolymerization (GO:0007019)3.34651057
74proline transport (GO:0015824)3.34021100
75germinal center formation (GO:0002467)3.32537202
76cardiac muscle cell action potential involved in contraction (GO:0086002)3.32422366
77regulation of antigen processing and presentation (GO:0002577)3.31711796
78regulation of potassium ion transmembrane transporter activity (GO:1901016)3.30623674
79cardiac muscle cell action potential (GO:0086001)3.30245826
80positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.29946319
81piRNA metabolic process (GO:0034587)3.29918121
82protein localization to kinetochore (GO:0034501)3.29620622
83cellular extravasation (GO:0045123)3.29363743
84regulation of gamma-delta T cell activation (GO:0046643)3.27291987
85histone arginine methylation (GO:0034969)3.26579466
86DNA double-strand break processing (GO:0000729)3.26492025
87prostate gland growth (GO:0060736)3.26384902
88head development (GO:0060322)3.20213871
89defense response to protozoan (GO:0042832)3.19988518
90positive thymic T cell selection (GO:0045059)3.18878924
91DNA damage response, signal transduction resulting in transcription (GO:0042772)3.15719804
92negative regulation of lymphocyte mediated immunity (GO:0002707)3.15624234
93mitotic sister chromatid cohesion (GO:0007064)3.15476147
94lung-associated mesenchyme development (GO:0060484)3.15062578
95cerebellar Purkinje cell differentiation (GO:0021702)3.13143334
96regulation of interferon-alpha production (GO:0032647)3.12792280
97thymic T cell selection (GO:0045061)3.12247160
98ribosome assembly (GO:0042255)3.11347036
99positive regulation of type 2 immune response (GO:0002830)3.10200640
100purine nucleobase biosynthetic process (GO:0009113)3.08200800
101positive regulation of antigen processing and presentation (GO:0002579)3.06116660
102regulation of mitotic spindle organization (GO:0060236)3.04019819
103regulation of type I interferon-mediated signaling pathway (GO:0060338)3.03526124
104cellular response to interferon-gamma (GO:0071346)3.02818207
105B cell homeostasis (GO:0001782)3.02704930
106folic acid transport (GO:0015884)3.01056025
107positive regulation of cellular amide metabolic process (GO:0034250)3.00449586
108regulation of T cell tolerance induction (GO:0002664)2.99826813
109regulation of gene silencing by RNA (GO:0060966)2.97792418
110regulation of posttranscriptional gene silencing (GO:0060147)2.97792418
111regulation of gene silencing by miRNA (GO:0060964)2.97792418
112regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.97374138
113regulation of natural killer cell mediated immunity (GO:0002715)2.97374138
114negative regulation of viral genome replication (GO:0045071)2.97026003
115interferon-gamma secretion (GO:0072643)2.95865769
116NADH metabolic process (GO:0006734)2.94715234
117response to interferon-beta (GO:0035456)2.94666858
118T-helper 1 type immune response (GO:0042088)2.92870005
119DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.92536094
120regulation of alpha-beta T cell proliferation (GO:0046640)2.92471320
121positive regulation of B cell differentiation (GO:0045579)2.92331720
122response to interleukin-15 (GO:0070672)2.90887939
123protein complex localization (GO:0031503)2.89572291
124myeloid dendritic cell differentiation (GO:0043011)2.89552102
125nucleobase biosynthetic process (GO:0046112)2.88838299
126positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.88234096
127ribosome biogenesis (GO:0042254)2.88223369
128response to protozoan (GO:0001562)2.86885077
129negative regulation of innate immune response (GO:0045824)2.86813308
130DNA replication-dependent nucleosome assembly (GO:0006335)2.86382488
131DNA replication-dependent nucleosome organization (GO:0034723)2.86382488
132regulation of B cell differentiation (GO:0045577)2.85864973
133CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.84108647
134adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.83522640
135histone H2A ubiquitination (GO:0033522)2.82878898
136negative regulation of leukocyte mediated immunity (GO:0002704)2.82722803
137microglial cell activation (GO:0001774)2.82442112
138regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.82404284
139intra-S DNA damage checkpoint (GO:0031573)2.81636166
140positive regulation of interferon-beta production (GO:0032728)2.79054017
141regulation of membrane repolarization (GO:0060306)2.78782341
142response to interferon-gamma (GO:0034341)2.78683200
143microtubule severing (GO:0051013)2.78403963
144cardiac conduction (GO:0061337)2.77183575
145T cell selection (GO:0045058)2.77014056
146negative regulation of T cell mediated immunity (GO:0002710)2.76168386
147myeloid dendritic cell activation (GO:0001773)2.74795829
148cellular protein complex localization (GO:0034629)2.73260950
149leukocyte aggregation (GO:0070486)2.71776088
150regulation of helicase activity (GO:0051095)2.71318287
151regulation of type 2 immune response (GO:0002828)2.69537388
152establishment of chromosome localization (GO:0051303)2.68955201
153regulation of tolerance induction (GO:0002643)2.68614380
154regulation of exit from mitosis (GO:0007096)2.68148810
155lymphocyte chemotaxis (GO:0048247)2.68148493
156positive regulation of T cell mediated cytotoxicity (GO:0001916)2.67986606
157folic acid metabolic process (GO:0046655)2.67762512
158mitotic nuclear envelope disassembly (GO:0007077)2.67204086
159respiratory burst (GO:0045730)2.66165932
160amino sugar catabolic process (GO:0046348)2.65027861
161somatic diversification of immune receptors via somatic mutation (GO:0002566)2.64039474
162somatic hypermutation of immunoglobulin genes (GO:0016446)2.64039474
163cellular response to interleukin-15 (GO:0071350)2.63857263
164tricarboxylic acid cycle (GO:0006099)2.63073609
165regulation of synaptic transmission, dopaminergic (GO:0032225)2.62659035
166tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.62164353
167RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.62164353
168regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.62152219
169planar cell polarity pathway involved in neural tube closure (GO:0090179)2.61968340
170regulation of centrosome cycle (GO:0046605)2.61489287
171negative regulation of keratinocyte proliferation (GO:0010839)2.61483609
172regulation of interleukin-2 biosynthetic process (GO:0045076)2.61045853
173rRNA modification (GO:0000154)2.60852410
174regulation of T cell mediated cytotoxicity (GO:0001914)2.60798421
175cell migration in hindbrain (GO:0021535)2.58974056
176antigen receptor-mediated signaling pathway (GO:0050851)2.58957811
177positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.56574867
178regulation of chromosome segregation (GO:0051983)2.54063284
179rRNA methylation (GO:0031167)2.53959194
180mitotic chromosome condensation (GO:0007076)2.52818729
181short-term memory (GO:0007614)2.52531207
182regulation of sister chromatid cohesion (GO:0007063)2.51136359
183membrane disassembly (GO:0030397)2.47936172
184nuclear envelope disassembly (GO:0051081)2.47936172
185maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.47634371
186positive regulation of macroautophagy (GO:0016239)2.47407982
187regulation of keratinocyte proliferation (GO:0010837)2.47321461
188DNA replication initiation (GO:0006270)2.46945999
189chromosome segregation (GO:0007059)2.45495058
190regulation of translational termination (GO:0006449)2.43757876
191female gonad development (GO:0008585)2.42918936
192regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.42310868
193protein localization to chromosome, centromeric region (GO:0071459)2.42264131
194DNA replication checkpoint (GO:0000076)2.38318398
195hemidesmosome assembly (GO:0031581)2.37336673
196regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.36047228
197regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.36047228
198regulation of potassium ion transmembrane transport (GO:1901379)2.35742542
199morphogenesis of an epithelial fold (GO:0060571)2.35561013
200regulation of transforming growth factor beta1 production (GO:0032908)2.33501792

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.02110243
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.19885601
3E2F7_22180533_ChIP-Seq_HELA_Human4.15006859
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.90198939
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.79906052
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.74365843
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.47135133
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.33503675
9EGR1_19374776_ChIP-ChIP_THP-1_Human3.29272230
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.09489271
11AR_21909140_ChIP-Seq_LNCAP_Human3.02475159
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.99005862
13MYC_22102868_ChIP-Seq_BL_Human2.96277489
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.91455350
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.79517205
16NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.75396353
17BP1_19119308_ChIP-ChIP_Hs578T_Human2.74493328
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.73433613
19KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.72286611
20KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.72286611
21KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.72286611
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.70061205
23NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.65402034
24IRF8_27001747_Chip-Seq_BMDM_Mouse2.61261559
25STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.57892541
26MYC_19079543_ChIP-ChIP_MESCs_Mouse2.57575699
27* CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.54655749
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.49140931
29SPI1_23547873_ChIP-Seq_NB4_Human2.48146966
30MYB_26560356_Chip-Seq_TH2_Human2.40936167
31MYB_21317192_ChIP-Seq_ERMYB_Mouse2.33621963
32NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.30032733
33ELF1_17652178_ChIP-ChIP_JURKAT_Human2.28556466
34KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.27685225
35STAT4_19710469_ChIP-ChIP_TH1__Mouse2.27455363
36RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.24304489
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.22309975
38MAF_26560356_Chip-Seq_TH1_Human2.21287699
39VDR_21846776_ChIP-Seq_THP-1_Human2.20882762
40E2F4_17652178_ChIP-ChIP_JURKAT_Human2.20604184
41MYC_18555785_ChIP-Seq_MESCs_Mouse2.13178689
42SALL1_21062744_ChIP-ChIP_HESCs_Human2.11630414
43ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.08060626
44FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.07512998
45MYB_26560356_Chip-Seq_TH1_Human2.06460994
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.00205263
47* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.99331472
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.95187309
49POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.93671445
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.92128041
51VDR_24763502_ChIP-Seq_THP-1_Human1.91756866
52VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.91166546
53RUNX_20019798_ChIP-Seq_JUKART_Human1.91084874
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.91083725
55UTX_26944678_Chip-Seq_JUKART_Human1.88492752
56CIITA_25753668_ChIP-Seq_RAJI_Human1.86728306
57SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.85758069
58E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.85547150
59NANOG_18555785_ChIP-Seq_MESCs_Mouse1.83927511
60BRD4_27068464_Chip-Seq_AML-cells_Mouse1.74468821
61ESR1_15608294_ChIP-ChIP_MCF-7_Human1.73719393
62FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.72938173
63ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.69584500
64MAF_26560356_Chip-Seq_TH2_Human1.68935311
65CREB1_15753290_ChIP-ChIP_HEK293T_Human1.68302336
66GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.68030731
67SPI1_23127762_ChIP-Seq_K562_Human1.67758017
68RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66928122
69FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.66729826
70STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.65511843
71NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.62133064
72RUNX1_22412390_ChIP-Seq_EML_Mouse1.60320635
73* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.59319952
74STAT6_21828071_ChIP-Seq_BEAS2B_Human1.58567728
75MYC_19030024_ChIP-ChIP_MESCs_Mouse1.56313866
76CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.52442328
77* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.49297005
78GATA1_22025678_ChIP-Seq_K562_Human1.48716696
79* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.47812283
80RBPJ_22232070_ChIP-Seq_NCS_Mouse1.46583874
81NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.44700361
82RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.43984956
83SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.43621734
84SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.42860661
85* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.42836937
86FUS_26573619_Chip-Seq_HEK293_Human1.41048736
87TFEB_21752829_ChIP-Seq_HELA_Human1.39961128
88CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.39709982
89GATA3_27048872_Chip-Seq_THYMUS_Human1.38204016
90MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.35635137
91KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.34465367
92TCF7_22412390_ChIP-Seq_EML_Mouse1.33890147
93* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.33189544
94GBX2_23144817_ChIP-Seq_PC3_Human1.31603407
95MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.31318569
96NANOG_16153702_ChIP-ChIP_HESCs_Human1.31295697
97KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.29577024
98Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.26997914
99TCF3_18692474_ChIP-Seq_MEFs_Mouse1.26630389
100E2F1_21310950_ChIP-Seq_MCF-7_Human1.26540962
101POU5F1_16153702_ChIP-ChIP_HESCs_Human1.24024307
102NANOG_21062744_ChIP-ChIP_HESCs_Human1.23212484
103TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22058820
104HOXB4_20404135_ChIP-ChIP_EML_Mouse1.22013792
105KAP1_22055183_ChIP-Seq_ESCs_Mouse1.21930280
106GATA1_26923725_Chip-Seq_HPCs_Mouse1.21539197
107TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.21522977
108YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21350404
109GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.20109214
110GATA3_26560356_Chip-Seq_TH2_Human1.19196002
111PU_27001747_Chip-Seq_BMDM_Mouse1.16964017
112ELK3_25401928_ChIP-Seq_HUVEC_Human1.15778686
113GATA2_22383799_ChIP-Seq_G1ME_Mouse1.15577331
114EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.15320726
115* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15190503
116CTBP2_25329375_ChIP-Seq_LNCAP_Human1.14998095
117POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.14393821
118KDM2B_26808549_Chip-Seq_SUP-B15_Human1.14038085
119VDR_24787735_ChIP-Seq_THP-1_Human1.13845112
120RNF2_27304074_Chip-Seq_NSC_Mouse1.13081944
121MYC_18358816_ChIP-ChIP_MESCs_Mouse1.11972425
122NELFA_20434984_ChIP-Seq_ESCs_Mouse1.11907938
123* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11347007
124ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10703539
125SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10267394
126PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09998735
127STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.09922566
128PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09917061
129SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.09811497
130* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.09479181
131MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.08279650
132NOTCH1_21737748_ChIP-Seq_TLL_Human1.07889913
133EWS_26573619_Chip-Seq_HEK293_Human1.06523295
134EST1_17652178_ChIP-ChIP_JURKAT_Human1.06010482
135* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.04396108
136KDM5A_27292631_Chip-Seq_BREAST_Human1.04102809
137FOXP3_21729870_ChIP-Seq_TREG_Human1.03996996
138KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.03724027
139SOX2_16153702_ChIP-ChIP_HESCs_Human1.03616155
140ETS1_20019798_ChIP-Seq_JURKAT_Human1.03272277
141SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02133074
142ZFP57_27257070_Chip-Seq_ESCs_Mouse1.01904106
143GABP_17652178_ChIP-ChIP_JURKAT_Human1.01593384
144PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01013412
145TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.00806393
146NANOG_16518401_ChIP-PET_MESCs_Mouse1.00195435
147* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99886218
148* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.99737682
149MYCN_18555785_ChIP-Seq_MESCs_Mouse0.99315322
150GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98757246
151* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.97182606
152ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.97163712
153TP63_17297297_ChIP-ChIP_HaCaT_Human0.97144874
154NFE2_27457419_Chip-Seq_LIVER_Mouse0.96356727
155SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.95334019
156KDM2B_26808549_Chip-Seq_DND41_Human0.94459204
157GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.94361665
158YY1_21170310_ChIP-Seq_MESCs_Mouse0.92908446
159BMI1_23680149_ChIP-Seq_NPCS_Mouse0.92396922
160* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92318132
161* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.91588247
162* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90913032
163HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.90789431
164CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.90733589
165PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90722182
166* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.90696594
167* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90191222
168TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90100033
169POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90100033
170STAT3_1855785_ChIP-Seq_MESCs_Mouse0.89865119
171HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.89726646
172ZFP281_18757296_ChIP-ChIP_E14_Mouse0.89555839
173NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.89188529
174TAF15_26573619_Chip-Seq_HEK293_Human0.88721950
175HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.88472519
176PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88213277
177CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.88187554
178KAP1_27257070_Chip-Seq_ESCs_Mouse0.87440728
179GATA1_19941827_ChIP-Seq_MEL_Mouse0.87079180
180XRN2_22483619_ChIP-Seq_HELA_Human0.86866941
181CTBP1_25329375_ChIP-Seq_LNCAP_Human0.86475719
182CBX2_27304074_Chip-Seq_ESCs_Mouse0.85428604
183* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.85176883
184NANOG_18692474_ChIP-Seq_MEFs_Mouse0.84906095
185VDR_23849224_ChIP-Seq_CD4+_Human0.84095717
186CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.83396606
187NCOR1_26117541_ChIP-Seq_K562_Human0.82172704
188* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.80753151
189BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.78100471
190CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.77746489
191* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.76134475
192CLOCK_20551151_ChIP-Seq_293T_Human0.75693376

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008004_abnormal_stomach_pH7.20753266
2MP0001346_abnormal_lacrimal_gland4.22759239
3MP0001835_abnormal_antigen_presentation4.10922190
4MP0000685_abnormal_immune_system3.75492887
5MP0005671_abnormal_response_to3.40439236
6MP0005387_immune_system_phenotype3.17816489
7MP0001790_abnormal_immune_system3.17816489
8MP0001800_abnormal_humoral_immune3.13900482
9MP0003436_decreased_susceptibility_to3.13529503
10MP0002254_reproductive_system_inflammat3.06654195
11MP0003303_peritoneal_inflammation3.02222112
12MP0003724_increased_susceptibility_to2.84135413
13MP0005000_abnormal_immune_tolerance2.73121831
14MP0003123_paternal_imprinting2.71227340
15MP0002452_abnormal_antigen_presenting2.64103052
16MP0009785_altered_susceptibility_to2.62171527
17MP0005025_abnormal_response_to2.58006856
18MP0002723_abnormal_immune_serum2.57697324
19MP0002419_abnormal_innate_immunity2.54688078
20MP0003890_abnormal_embryonic-extraembry2.53135460
21MP0002420_abnormal_adaptive_immunity2.38505217
22MP0001819_abnormal_immune_cell2.36731846
23MP0003763_abnormal_thymus_physiology2.34970039
24MP0008877_abnormal_DNA_methylation2.31886055
25MP0003693_abnormal_embryo_hatching2.28102048
26MP0004957_abnormal_blastocyst_morpholog2.27533174
27MP0002166_altered_tumor_susceptibility2.14752902
28MP0002148_abnormal_hypersensitivity_rea2.09513247
29MP0003111_abnormal_nucleus_morphology2.09063321
30MP0008260_abnormal_autophagy2.09038314
31MP0002653_abnormal_ependyma_morphology2.06881211
32MP0004859_abnormal_synaptic_plasticity2.04414450
33MP0002405_respiratory_system_inflammati1.99383681
34MP0002398_abnormal_bone_marrow1.97101070
35MP0005171_absent_coat_pigmentation1.96164654
36MP0000716_abnormal_immune_system1.95189278
37MP0010094_abnormal_chromosome_stability1.91385669
38MP0003077_abnormal_cell_cycle1.89966343
39MP0006082_CNS_inflammation1.87973306
40MP0004947_skin_inflammation1.86844513
41MP0003191_abnormal_cellular_cholesterol1.81823984
42MP0003172_abnormal_lysosome_physiology1.79120714
43MP0005248_abnormal_Harderian_gland1.78854403
44MP0005623_abnormal_meninges_morphology1.75612481
45MP0003937_abnormal_limbs/digits/tail_de1.72803558
46MP0010030_abnormal_orbit_morphology1.72299692
47MP0003300_gastrointestinal_ulcer1.70692894
48MP0000537_abnormal_urethra_morphology1.69464445
49MP0001845_abnormal_inflammatory_respons1.68424968
50MP0003718_maternal_effect1.68175746
51MP0003787_abnormal_imprinting1.67374237
52MP0009333_abnormal_splenocyte_physiolog1.66834551
53MP0003941_abnormal_skin_development1.62092682
54MP0010155_abnormal_intestine_physiology1.61061291
55MP0000689_abnormal_spleen_morphology1.60090879
56MP0002722_abnormal_immune_system1.58772401
57MP0002429_abnormal_blood_cell1.58491747
58MP0003091_abnormal_cell_migration1.56549816
59MP0002006_tumorigenesis1.54586608
60MP0005464_abnormal_platelet_physiology1.54157630
61MP0008932_abnormal_embryonic_tissue1.51959821
62MP0008057_abnormal_DNA_replication1.51942130
63MP0000858_altered_metastatic_potential1.51275485
64MP0002822_catalepsy1.50078425
65MP0001533_abnormal_skeleton_physiology1.44465403
66MP0000566_synostosis1.44230085
67MP0002396_abnormal_hematopoietic_system1.42949231
68MP0009046_muscle_twitch1.42660863
69MP0000703_abnormal_thymus_morphology1.42535672
70MP0004381_abnormal_hair_follicle1.41343502
71MP0003121_genomic_imprinting1.41047045
72MP0000015_abnormal_ear_pigmentation1.39968019
73MP0005058_abnormal_lysosome_morphology1.39309379
74MP0005310_abnormal_salivary_gland1.37862296
75MP0008789_abnormal_olfactory_epithelium1.37373972
76MP0005499_abnormal_olfactory_system1.34846093
77MP0005394_taste/olfaction_phenotype1.34846093
78MP0003786_premature_aging1.32887662
79MP0010678_abnormal_skin_adnexa1.31687864
80MP0004133_heterotaxia1.30846065
81MP0002084_abnormal_developmental_patter1.30119506
82MP0003938_abnormal_ear_development1.29925598
83MP0003183_abnormal_peptide_metabolism1.29548757
84MP0008007_abnormal_cellular_replicative1.28997718
85MP0003136_yellow_coat_color1.28842684
86MP0005451_abnormal_body_composition1.28260517
87MP0002233_abnormal_nose_morphology1.27176799
88MP0002249_abnormal_larynx_morphology1.27077899
89MP0000762_abnormal_tongue_morphology1.26955989
90MP0009053_abnormal_anal_canal1.25733025
91MP0000350_abnormal_cell_proliferation1.24344299
92MP0001853_heart_inflammation1.23577067
93MP0001849_ear_inflammation1.23048214
94MP0008469_abnormal_protein_level1.22150260
95MP0003755_abnormal_palate_morphology1.22101357
96MP0000534_abnormal_ureter_morphology1.21543184
97MP0004019_abnormal_vitamin_homeostasis1.20080719
98MP0000569_abnormal_digit_pigmentation1.19566790
99MP0003879_abnormal_hair_cell1.19424590
100MP0000371_diluted_coat_color1.18554038
101MP0003122_maternal_imprinting1.17104588
102MP0000383_abnormal_hair_follicle1.15124328
103MP0003119_abnormal_digestive_system1.13226967
104MP0001486_abnormal_startle_reflex1.12885317
105MP0010234_abnormal_vibrissa_follicle1.11997870
106MP0002085_abnormal_embryonic_tissue1.11597158
107MP0000631_abnormal_neuroendocrine_gland1.06787025
108MP0002102_abnormal_ear_morphology1.06235364
109MP0002095_abnormal_skin_pigmentation1.05742719
110MP0004808_abnormal_hematopoietic_stem1.05668073
111MP0002009_preneoplasia1.05008201
112MP0002998_abnormal_bone_remodeling1.04934162
113MP0002735_abnormal_chemical_nociception1.04699609
114MP0002877_abnormal_melanocyte_morpholog1.04129343
115MP0003656_abnormal_erythrocyte_physiolo1.03408476
116MP0005075_abnormal_melanosome_morpholog1.02854262
117MP0009763_increased_sensitivity_to1.02013462
118MP0005076_abnormal_cell_differentiation1.01805004
119MP0006054_spinal_hemorrhage1.00945833
120MP0001672_abnormal_embryogenesis/_devel1.00603048
121MP0005380_embryogenesis_phenotype1.00603048
122MP0004883_abnormal_blood_vessel1.00568583
123MP0001881_abnormal_mammary_gland0.99300492
124MP0005367_renal/urinary_system_phenotyp0.98305246
125MP0000516_abnormal_urinary_system0.98305246
126MP0001730_embryonic_growth_arrest0.97965790
127MP0000428_abnormal_craniofacial_morphol0.97946349
128MP0002132_abnormal_respiratory_system0.97337850
129MP0003635_abnormal_synaptic_transmissio0.97135719
130MP0001697_abnormal_embryo_size0.96883063
131MP0006292_abnormal_olfactory_placode0.96847061
132MP0003866_abnormal_defecation0.96754457
133MP0000467_abnormal_esophagus_morphology0.96536370
134MP0000470_abnormal_stomach_morphology0.95932769
135MP0001177_atelectasis0.95679745
136MP0009250_abnormal_appendicular_skeleto0.94897939
137MP0009764_decreased_sensitivity_to0.94808831
138MP0000490_abnormal_crypts_of0.92471501
139MP0005395_other_phenotype0.90959692
140MP0000579_abnormal_nail_morphology0.90956683
141MP0010352_gastrointestinal_tract_polyps0.90741068
142MP0004197_abnormal_fetal_growth/weight/0.90565249
143MP0009278_abnormal_bone_marrow0.90442324
144MP0000343_altered_response_to0.89634428
145MP0005408_hypopigmentation0.89468043
146MP0003566_abnormal_cell_adhesion0.88040173
147MP0003861_abnormal_nervous_system0.86836313
148MP0001873_stomach_inflammation0.86705272
149MP0003448_altered_tumor_morphology0.86673775
150MP0003828_pulmonary_edema0.86331309
151MP0002063_abnormal_learning/memory/cond0.85540306
152MP0000465_gastrointestinal_hemorrhage0.84259852
153MP0002272_abnormal_nervous_system0.83367527
154MP0003115_abnormal_respiratory_system0.83249957
155MP0003936_abnormal_reproductive_system0.82863201
156MP0000627_abnormal_mammary_gland0.82442387
157MP0004272_abnormal_basement_membrane0.81677839
158MP0002019_abnormal_tumor_incidence0.81282983
159MP0003935_abnormal_craniofacial_develop0.80186805
160MP0000432_abnormal_head_morphology0.79888780
161MP0002282_abnormal_trachea_morphology0.79803915
162MP0004510_myositis0.79070785
163MP0008058_abnormal_DNA_repair0.78454727
164MP0001299_abnormal_eye_distance/0.78452790
165MP0005501_abnormal_skin_physiology0.78220763
166MP0005174_abnormal_tail_pigmentation0.78164785
167MP0002234_abnormal_pharynx_morphology0.77925740
168MP0003632_abnormal_nervous_system0.77340860
169MP0001286_abnormal_eye_development0.76482809
170MP0005164_abnormal_response_to0.76360251
171MP0003984_embryonic_growth_retardation0.76248991
172MP0009745_abnormal_behavioral_response0.75767055
173MP0002108_abnormal_muscle_morphology0.75381732
174MP0002088_abnormal_embryonic_growth/wei0.75202456
175MP0003283_abnormal_digestive_organ0.74926520
176MP0001485_abnormal_pinna_reflex0.74718832
177MP0000372_irregular_coat_pigmentation0.74287960
178MP0005621_abnormal_cell_physiology0.72818071
179MP0002064_seizures0.72134592
180MP0002697_abnormal_eye_size0.71505135
181MP0000604_amyloidosis0.71458216
182MP0002933_joint_inflammation0.70592176
183MP0003045_fibrosis0.70362006
184MP0001851_eye_inflammation0.69164035
185MP0005390_skeleton_phenotype0.68485602
186MP0001915_intracranial_hemorrhage0.67259700
187MP0002075_abnormal_coat/hair_pigmentati0.64538275
188MP0009765_abnormal_xenobiotic_induced0.63847044
189MP0000249_abnormal_blood_vessel0.63607221
190MP0009840_abnormal_foam_cell0.62367989

Predicted human phenotypes

RankGene SetZ-score
1Ventricular fibrillation (HP:0001663)6.60490826
2Abnormality of the labia minora (HP:0012880)5.40577033
3Eczematoid dermatitis (HP:0000976)4.85755803
4Abnormal delayed hypersensitivity skin test (HP:0002963)4.77329126
5Recurrent bacterial skin infections (HP:0005406)4.53142272
6Abnormality of macrophages (HP:0004311)4.35490060
7Recurrent abscess formation (HP:0002722)4.12761571
8Focal motor seizures (HP:0011153)4.04939200
9Meningitis (HP:0001287)4.02798818
10Retrobulbar optic neuritis (HP:0100654)4.00107996
11Optic neuritis (HP:0100653)4.00107996
12Orchitis (HP:0100796)3.95834065
13Mediastinal lymphadenopathy (HP:0100721)3.95545193
14Increased IgM level (HP:0003496)3.95149806
15Recurrent cutaneous fungal infections (HP:0011370)3.90068618
16Chronic mucocutaneous candidiasis (HP:0002728)3.90068618
17Myositis (HP:0100614)3.88912650
18Encephalitis (HP:0002383)3.84512566
19Recurrent fungal infections (HP:0002841)3.78908138
20Recurrent viral infections (HP:0004429)3.76780749
21Vasculitis (HP:0002633)3.75852493
22Panhypogammaglobulinemia (HP:0003139)3.72765771
23Colitis (HP:0002583)3.69928277
24Agammaglobulinemia (HP:0004432)3.53754596
25Recurrent skin infections (HP:0001581)3.44366519
26Gastrointestinal stroma tumor (HP:0100723)3.38650356
27Abnormality of cells of the lymphoid lineage (HP:0012140)3.36860114
28Recurrent bronchitis (HP:0002837)3.33967599
29Lymphopenia (HP:0001888)3.33047844
30Febrile seizures (HP:0002373)3.28351114
31Increased IgE level (HP:0003212)3.26945217
32Viral hepatitis (HP:0006562)3.25985330
33Shawl scrotum (HP:0000049)3.20254488
34Atonic seizures (HP:0010819)3.13931478
35Inflammation of the large intestine (HP:0002037)3.13340588
36Cellulitis (HP:0100658)3.12467270
37Gastrointestinal infarctions (HP:0005244)3.12416513
38Pulmonary infiltrates (HP:0002113)3.09965369
39IgM deficiency (HP:0002850)3.09900412
40Recurrent gram-negative bacterial infections (HP:0005420)3.08755191
41Abnormality of T cell number (HP:0011839)3.05952064
42Abnormality of T cell physiology (HP:0011840)3.01633092
43Gastrointestinal inflammation (HP:0004386)3.00813456
44IgA deficiency (HP:0002720)3.00753442
45Urethral obstruction (HP:0000796)3.00158571
46IgG deficiency (HP:0004315)2.92807205
47Abnormality of T cells (HP:0002843)2.91057939
48T lymphocytopenia (HP:0005403)2.89314059
49Facial cleft (HP:0002006)2.78993584
50Granulocytopenia (HP:0001913)2.78735372
51Chronic obstructive pulmonary disease (HP:0006510)2.75345125
52Obstructive lung disease (HP:0006536)2.75345125
53Hypergammaglobulinemia (HP:0010702)2.74327386
54Progressive inability to walk (HP:0002505)2.73307337
55Keratoconjunctivitis sicca (HP:0001097)2.73283568
56Chest pain (HP:0100749)2.69827629
57Recurrent sinusitis (HP:0011108)2.69407869
58Autoimmune hemolytic anemia (HP:0001890)2.62124614
59Pustule (HP:0200039)2.60941604
60Orthostatic hypotension (HP:0001278)2.60705627
61Restrictive lung disease (HP:0002091)2.58883669
62Urticaria (HP:0001025)2.57715166
63Eosinophilia (HP:0001880)2.55709485
64Chronic otitis media (HP:0000389)2.53146951
65Hemoptysis (HP:0002105)2.52068443
66Elevated erythrocyte sedimentation rate (HP:0003565)2.51184604
67Lip pit (HP:0100267)2.49968405
68Emphysema (HP:0002097)2.49873246
69Resting tremor (HP:0002322)2.49106722
70Oligomenorrhea (HP:0000876)2.47664833
71Recurrent lower respiratory tract infections (HP:0002783)2.45504682
72Abnormality of the pleura (HP:0002103)2.41853907
73Abnormality of the antihelix (HP:0009738)2.40709417
74Carpal bone hypoplasia (HP:0001498)2.39829944
75Gingivitis (HP:0000230)2.39330613
76Spontaneous hematomas (HP:0007420)2.38278414
77Prolonged QT interval (HP:0001657)2.36227374
78Systemic lupus erythematosus (HP:0002725)2.34031651
79Abnormality of the lower motor neuron (HP:0002366)2.33573572
80Keratoconjunctivitis (HP:0001096)2.33474968
81Papillary thyroid carcinoma (HP:0002895)2.33416707
82Hepatitis (HP:0012115)2.33252374
83Osteomyelitis (HP:0002754)2.32872042
84Fatigue (HP:0012378)2.32826908
85Chronic diarrhea (HP:0002028)2.32738208
86Basal cell carcinoma (HP:0002671)2.30806752
87Selective tooth agenesis (HP:0001592)2.28863101
88Complete atrioventricular canal defect (HP:0001674)2.27313083
89Birth length less than 3rd percentile (HP:0003561)2.26490039
90Abnormality of the astrocytes (HP:0100707)2.25450181
91Astrocytoma (HP:0009592)2.25450181
92Inability to walk (HP:0002540)2.23880101
93Recurrent pneumonia (HP:0006532)2.23603795
94Arterial thrombosis (HP:0004420)2.23365998
95Abnormality of dentin (HP:0010299)2.22666004
96Absent eyebrow (HP:0002223)2.22429201
97Lymphoma (HP:0002665)2.21827224
98Facial hemangioma (HP:0000329)2.20611911
99Patellar aplasia (HP:0006443)2.17137303
100Esophageal atresia (HP:0002032)2.16774772
101Leukocytosis (HP:0001974)2.16594946
102Acute hepatic failure (HP:0006554)2.15059089
103Synostosis of carpal bones (HP:0005048)2.14372951
104Sepsis (HP:0100806)2.14020044
105Abnormality of the peritoneum (HP:0002585)2.13617229
106Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.13197361
107Autoimmune thrombocytopenia (HP:0001973)2.12906114
108Spondylolisthesis (HP:0003302)2.09602121
109Subacute progressive viral hepatitis (HP:0006572)2.07988921
110Abnormality of the fovea (HP:0000493)2.07476075
111Syncope (HP:0001279)2.07177560
112Ventricular arrhythmia (HP:0004308)2.06775248
113Neonatal short-limb short stature (HP:0008921)2.04544831
114Aplasia/Hypoplasia of the sternum (HP:0006714)2.03750101
115Nasal polyposis (HP:0100582)2.03590715
116Aplasia/Hypoplasia of the patella (HP:0006498)2.03435849
117Delayed puberty (HP:0000823)2.03058370
118Abnormality of the dental pulp (HP:0006479)2.02922891
119Gangrene (HP:0100758)2.02366997
120Skin ulcer (HP:0200042)2.02126118
121Anophthalmia (HP:0000528)2.00111686
122Thick nail (HP:0001805)1.99614695
123Carpal synostosis (HP:0009702)1.98237058
124Abnormality of the prostate (HP:0008775)1.97285426
125Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.96842755
126Milia (HP:0001056)1.96765515
127Chromosomal breakage induced by crosslinking agents (HP:0003221)1.96187478
128Verrucae (HP:0200043)1.96139422
129Papilloma (HP:0012740)1.96139422
130Interstitial pulmonary disease (HP:0006530)1.95588586
131Fetal akinesia sequence (HP:0001989)1.93761525
132Abnormality of the labia (HP:0000058)1.93675632
133Spinal cord compression (HP:0002176)1.93621770
134Absent radius (HP:0003974)1.93355008
135Absent eyelashes (HP:0000561)1.92475796
136Anterior segment dysgenesis (HP:0007700)1.91651373
137Sparse lateral eyebrow (HP:0005338)1.89894494
138Breast aplasia (HP:0100783)1.89783229
139Ependymoma (HP:0002888)1.89127887
140Hypertensive crisis (HP:0100735)1.88829304
141Labial hypoplasia (HP:0000066)1.87967297
142Aplasia/hypoplasia of the humerus (HP:0006507)1.87690435
143Skin rash (HP:0000988)1.87688139
144Albinism (HP:0001022)1.87014851
145Abnormality of eosinophils (HP:0001879)1.85708221
146Poor suck (HP:0002033)1.85585013
147Abnormality of the preputium (HP:0100587)1.84591791
148Anorexia (HP:0002039)1.84458752
149Pulmonary embolism (HP:0002204)1.84171001
150Arthralgia (HP:0002829)1.83327590
151Bifid tongue (HP:0010297)1.83063676
152Amaurosis fugax (HP:0100576)1.82353159
153Keratitis (HP:0000491)1.81661582
154Chromsome breakage (HP:0040012)1.81524010
155Villous atrophy (HP:0011473)1.80882581
156Abnormality of small intestinal villus morphology (HP:0011472)1.80882581
157Spastic diplegia (HP:0001264)1.80820836
158Hypoplastic female external genitalia (HP:0012815)1.79972160
159Glomerulopathy (HP:0100820)1.79658113
160Absent forearm bone (HP:0003953)1.79154451
161Aplasia involving forearm bones (HP:0009822)1.79154451
162Squamous cell carcinoma (HP:0002860)1.78245898
163Premature loss of primary teeth (HP:0006323)1.78156901
164Hypodontia (HP:0000668)1.77967883
165Vascular calcification (HP:0004934)1.77362371
166Absence seizures (HP:0002121)1.75827583
167Abnormal pancreas size (HP:0012094)1.75375161
168Generalized tonic-clonic seizures (HP:0002069)1.75343068
169Synostosis involving bones of the hand (HP:0004278)1.75194390
170Cerebral hypomyelination (HP:0006808)1.72414259
171Abnormality of the aortic arch (HP:0012303)1.71953714
172Aplasia/Hypoplasia of the breasts (HP:0010311)1.70092354
173Bilateral microphthalmos (HP:0007633)1.67638849
174Short humerus (HP:0005792)1.66797155
175Breast hypoplasia (HP:0003187)1.65991837
176Medulloblastoma (HP:0002885)1.65100878
177Abdominal situs inversus (HP:0003363)1.65051297
178Abnormality of abdominal situs (HP:0011620)1.65051297
179Aplasia/Hypoplasia of the uvula (HP:0010293)1.64466433
180Rhinitis (HP:0012384)1.62729323
181Oligodactyly (HP:0012165)1.62654695
182Bilateral sensorineural hearing impairment (HP:0008619)1.62564962
183Ectopic kidney (HP:0000086)1.61911294
184Hypoplasia of the capital femoral epiphysis (HP:0003090)1.61898835
185Fragile nails (HP:0001808)1.61164796
186Fibular aplasia (HP:0002990)1.60694509
187Atrioventricular canal defect (HP:0006695)1.60382571
188Horseshoe kidney (HP:0000085)1.59273318
189Cardiovascular calcification (HP:0011915)1.58248027
190Focal seizures (HP:0007359)1.57735026
191Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.57696055
192Pancreatic fibrosis (HP:0100732)1.57378632
193Abnormality of the lacrimal duct (HP:0011481)1.57134988
194Abnormal number of incisors (HP:0011064)1.57016230
195Parakeratosis (HP:0001036)1.56181863
196Intellectual disability, profound (HP:0002187)1.55418288
197Glioma (HP:0009733)1.54815965
198Increased serum pyruvate (HP:0003542)1.54669731
199Abnormality of glycolysis (HP:0004366)1.54669731
200Natal tooth (HP:0000695)1.53672824

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS15.52031500
2LATS25.04525234
3BLK3.77972056
4STK38L3.70270012
5EIF2AK13.68222838
6RIPK43.54391741
7MAP4K13.45160937
8TYK23.24624810
9ERN13.01641727
10PRPF4B2.67505040
11MAP3K142.50487922
12CDK82.49878299
13TSSK62.48159128
14IRAK42.41404997
15ERBB42.40083189
16FGFR42.33298217
17SIK32.28483975
18JAK12.23852690
19IKBKE2.18721923
20SIK22.14077910
21NME12.08766797
22TTK2.03523769
23CSK2.00719839
24MAP3K101.99755843
25TBK11.94570987
26MST41.90681532
27NEK11.88415051
28MAP3K91.86070527
29JAK31.85331319
30MAP2K31.83420549
31STK31.78450275
32NTRK31.76038119
33EPHA21.70324362
34EPHB11.70156186
35MAP3K41.68150153
36EIF2AK31.66753443
37NEK91.66227619
38EEF2K1.65897441
39BTK1.55260877
40BRD41.54821155
41CDC71.50056254
42STK241.48097697
43STK391.47735712
44SMG11.41429048
45PAK61.40807741
46MAP2K71.40416321
47STK381.39136418
48ZAP701.36001977
49GRK11.33397859
50CDK121.33198529
51AKT31.32523676
52SYK1.29629866
53RPS6KB21.29457785
54NEK21.24247331
55BUB11.23763380
56IKBKB1.23154744
57TESK21.22945263
58MKNK11.18788702
59SRPK11.18129985
60MKNK21.17938382
61LYN1.17555437
62HCK1.17466764
63FGR1.17043568
64EIF2AK21.16763364
65TAOK11.15258103
66MARK31.13748109
67EPHA31.13587848
68JAK21.13236852
69PDK41.10687974
70PDK31.10687974
71PLK11.10419039
72ALK1.09881954
73MAPKAPK31.08903980
74GRK61.08286130
75MAP3K31.07212004
76CAMK1D1.04439238
77FGFR31.03651446
78YES11.02162286
79DDR21.02159758
80CAMKK21.00316371
81PLK30.98914099
82TRIB30.97221057
83IRAK10.97122036
84CSF1R0.96968903
85BMPR20.94208260
86SIK10.93194324
87TXK0.92612003
88WEE10.92069054
89CHEK20.92008502
90KSR20.90462058
91LCK0.87008976
92PRKCI0.86710012
93DYRK30.85977534
94PAK40.85926372
95CDK40.84399365
96CHEK10.83943289
97FES0.83591898
98BRSK10.83100249
99MELK0.78019283
100CDK60.77758655
101PRKCG0.77655561
102DAPK10.77376797
103CHUK0.76218304
104DAPK20.75984829
105KIT0.75739334
106MAPK110.73934261
107PLK40.72393023
108AURKA0.71182464
109IRAK30.69310080
110ICK0.68915514
111RPS6KA40.68186941
112AURKB0.66471732
113TAOK20.66212676
114MAPK70.65264982
115AKT20.65252726
116DYRK20.64466193
117BRAF0.64132638
118MAP3K120.63723440
119CASK0.63477208
120MAP3K130.62845331
121NTRK20.62580623
122MATK0.62242921
123SGK30.61482439
124ITK0.61012718
125PLK20.60119502
126MOS0.59562676
127FER0.57850019
128NLK0.57044621
129MAPKAPK20.56630713
130TNK20.54754422
131PTK60.54648188
132MAP2K40.54093547
133ACVR1B0.53387866
134WNK40.53234748
135MAP3K80.52021333
136TAOK30.51875326
137PDK20.51060016
138PKN20.49761393
139PDGFRB0.49688921
140PRKD20.49097182
141CCNB10.48394997
142CDC42BPA0.47927927
143ATR0.47904292
144CDK10.47896104
145TEC0.47594625
146KSR10.46222770
147NME20.46215243
148BCKDK0.45924591
149MAP3K10.45360672
150TGFBR20.44827935
151MAPK100.44734568
152CDK70.43830806
153HIPK20.43786377
154MAP3K110.43116127
155MAP2K10.42113678
156GRK70.41521963
157ATM0.41294387
158PRKCQ0.39582676
159STK100.39104526
160MAP3K50.37919780
161DYRK1B0.37807214
162LRRK20.37530217
163RIPK10.37280781
164CDK20.36833048
165STK110.35452242
166FYN0.34969292
167RAF10.34966259
168PDGFRA0.33985273
169ERBB30.33865508
170MAP3K70.33429655
171MAP3K60.33266720
172PDK10.32904704
173CAMK40.32885533
174CAMK1G0.32274427
175DYRK1A0.31941143
176MUSK0.31821305
177PRKCE0.31007838
178CSNK1D0.30870243
179CSNK1E0.29659806
180PAK30.29256119
181FGFR10.29242271
182CSNK1G10.28285550
183MTOR0.27472348
184MINK10.26585122
185TYRO30.26557549

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.61380484
2Graft-versus-host disease_Homo sapiens_hsa053323.54131571
3Autoimmune thyroid disease_Homo sapiens_hsa053203.29030589
4RNA polymerase_Homo sapiens_hsa030203.27741833
5Staphylococcus aureus infection_Homo sapiens_hsa051503.06913157
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.05059347
7Antigen processing and presentation_Homo sapiens_hsa046122.91324230
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.87498037
9RNA transport_Homo sapiens_hsa030132.86009232
10Leishmaniasis_Homo sapiens_hsa051402.84988278
11Primary immunodeficiency_Homo sapiens_hsa053402.77137389
12Vitamin B6 metabolism_Homo sapiens_hsa007502.58791927
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.52707695
14Asthma_Homo sapiens_hsa053102.51630062
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.45909276
16Type I diabetes mellitus_Homo sapiens_hsa049402.33605126
17Synaptic vesicle cycle_Homo sapiens_hsa047212.31322920
18Cell cycle_Homo sapiens_hsa041102.28661970
19Collecting duct acid secretion_Homo sapiens_hsa049662.27502989
20Nicotine addiction_Homo sapiens_hsa050332.21077811
21Measles_Homo sapiens_hsa051622.18819812
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.11587276
23NF-kappa B signaling pathway_Homo sapiens_hsa040642.10220034
24Influenza A_Homo sapiens_hsa051642.09181336
25B cell receptor signaling pathway_Homo sapiens_hsa046622.07148610
26Herpes simplex infection_Homo sapiens_hsa051682.03429215
27Osteoclast differentiation_Homo sapiens_hsa043801.98767802
28Toll-like receptor signaling pathway_Homo sapiens_hsa046201.89669933
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.82572804
30Toxoplasmosis_Homo sapiens_hsa051451.78835317
31Tuberculosis_Homo sapiens_hsa051521.76326064
32Proteasome_Homo sapiens_hsa030501.74011530
33Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.71584616
34RNA degradation_Homo sapiens_hsa030181.70124044
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.66747786
36Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.64616253
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.64369654
38Hippo signaling pathway_Homo sapiens_hsa043901.59421790
39Other glycan degradation_Homo sapiens_hsa005111.59003463
40Oocyte meiosis_Homo sapiens_hsa041141.53885454
41Spliceosome_Homo sapiens_hsa030401.53226312
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.53067432
43Vibrio cholerae infection_Homo sapiens_hsa051101.51660726
44p53 signaling pathway_Homo sapiens_hsa041151.47163720
45mRNA surveillance pathway_Homo sapiens_hsa030151.45295067
46Hepatitis B_Homo sapiens_hsa051611.44676498
47Pyruvate metabolism_Homo sapiens_hsa006201.43537720
48TNF signaling pathway_Homo sapiens_hsa046681.41340859
49Homologous recombination_Homo sapiens_hsa034401.40294605
50RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.38575364
51Basal transcription factors_Homo sapiens_hsa030221.38376091
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.37700111
53Cyanoamino acid metabolism_Homo sapiens_hsa004601.37576648
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.35810521
55Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.34425162
56Biosynthesis of amino acids_Homo sapiens_hsa012301.34343193
57Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.29472755
58DNA replication_Homo sapiens_hsa030301.29403047
59Gastric acid secretion_Homo sapiens_hsa049711.28797129
60mTOR signaling pathway_Homo sapiens_hsa041501.28024190
61Apoptosis_Homo sapiens_hsa042101.26589247
62Hematopoietic cell lineage_Homo sapiens_hsa046401.25837020
63Mismatch repair_Homo sapiens_hsa034301.25791804
64Basal cell carcinoma_Homo sapiens_hsa052171.24930637
65Legionellosis_Homo sapiens_hsa051341.24703812
66NOD-like receptor signaling pathway_Homo sapiens_hsa046211.22318809
67Pyrimidine metabolism_Homo sapiens_hsa002401.20773244
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.20468108
69Oxidative phosphorylation_Homo sapiens_hsa001901.19796368
70Chemokine signaling pathway_Homo sapiens_hsa040621.17225745
71Malaria_Homo sapiens_hsa051441.16867648
72Hepatitis C_Homo sapiens_hsa051601.15774724
73TGF-beta signaling pathway_Homo sapiens_hsa043501.12735754
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.12718076
75Colorectal cancer_Homo sapiens_hsa052101.08801975
76Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.08070022
77Tight junction_Homo sapiens_hsa045301.07695171
78Carbon metabolism_Homo sapiens_hsa012001.07288402
79Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.06964739
80Notch signaling pathway_Homo sapiens_hsa043301.05637902
81Jak-STAT signaling pathway_Homo sapiens_hsa046301.04049304
82Acute myeloid leukemia_Homo sapiens_hsa052211.03720283
83Huntingtons disease_Homo sapiens_hsa050161.01986940
84T cell receptor signaling pathway_Homo sapiens_hsa046601.00223895
85Chronic myeloid leukemia_Homo sapiens_hsa052200.97680606
86Non-small cell lung cancer_Homo sapiens_hsa052230.96981068
87Purine metabolism_Homo sapiens_hsa002300.96432540
88Nucleotide excision repair_Homo sapiens_hsa034200.95737211
89African trypanosomiasis_Homo sapiens_hsa051430.95618666
90HTLV-I infection_Homo sapiens_hsa051660.94997705
91Fanconi anemia pathway_Homo sapiens_hsa034600.92731317
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.92298909
93Viral carcinogenesis_Homo sapiens_hsa052030.91899379
94Melanoma_Homo sapiens_hsa052180.87122452
95Pertussis_Homo sapiens_hsa051330.86417835
96GABAergic synapse_Homo sapiens_hsa047270.86408243
97Long-term potentiation_Homo sapiens_hsa047200.86266600
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85949268
99Hedgehog signaling pathway_Homo sapiens_hsa043400.84858657
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.84524669
101Pentose phosphate pathway_Homo sapiens_hsa000300.82232020
102Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.81314961
103Renal cell carcinoma_Homo sapiens_hsa052110.80966088
104Shigellosis_Homo sapiens_hsa051310.80804230
105Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.79129780
106Amphetamine addiction_Homo sapiens_hsa050310.77980894
107Lysosome_Homo sapiens_hsa041420.77488817
108AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73545811
109Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.73003276
110Prostate cancer_Homo sapiens_hsa052150.72981609
111ErbB signaling pathway_Homo sapiens_hsa040120.71997152
112beta-Alanine metabolism_Homo sapiens_hsa004100.71293798
113Dopaminergic synapse_Homo sapiens_hsa047280.69725596
114Glycosaminoglycan degradation_Homo sapiens_hsa005310.68831400
115Leukocyte transendothelial migration_Homo sapiens_hsa046700.66125960
116Non-homologous end-joining_Homo sapiens_hsa034500.65824228
117Taste transduction_Homo sapiens_hsa047420.64596035
118Phenylalanine metabolism_Homo sapiens_hsa003600.64507482
119One carbon pool by folate_Homo sapiens_hsa006700.64342008
120Rheumatoid arthritis_Homo sapiens_hsa053230.64256157
121Pancreatic cancer_Homo sapiens_hsa052120.63493500
122Parkinsons disease_Homo sapiens_hsa050120.63245199
123Endometrial cancer_Homo sapiens_hsa052130.62699634
124Thyroid cancer_Homo sapiens_hsa052160.62146968
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61929497
126MicroRNAs in cancer_Homo sapiens_hsa052060.60630177
127Epstein-Barr virus infection_Homo sapiens_hsa051690.60353561
128Glioma_Homo sapiens_hsa052140.59041124
129Melanogenesis_Homo sapiens_hsa049160.58047185
130Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57288765
131Small cell lung cancer_Homo sapiens_hsa052220.57038772
132Neurotrophin signaling pathway_Homo sapiens_hsa047220.56610158
133Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56057152
134Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55427669
135Inositol phosphate metabolism_Homo sapiens_hsa005620.51618918
136Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51563096
137Wnt signaling pathway_Homo sapiens_hsa043100.51366582
138Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50829104
139Gap junction_Homo sapiens_hsa045400.49945716
140Olfactory transduction_Homo sapiens_hsa047400.49582139
141GnRH signaling pathway_Homo sapiens_hsa049120.49416986
142Salmonella infection_Homo sapiens_hsa051320.47479143
143Systemic lupus erythematosus_Homo sapiens_hsa053220.46968401
144Serotonergic synapse_Homo sapiens_hsa047260.46813515
145Glucagon signaling pathway_Homo sapiens_hsa049220.46141966
146HIF-1 signaling pathway_Homo sapiens_hsa040660.46128537
147Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.44277575
148Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44022924
149Complement and coagulation cascades_Homo sapiens_hsa046100.43945140
150Viral myocarditis_Homo sapiens_hsa054160.43639731
151Pathways in cancer_Homo sapiens_hsa052000.42559462
152Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.42539719
153Proteoglycans in cancer_Homo sapiens_hsa052050.42380992
154Salivary secretion_Homo sapiens_hsa049700.42136724
155Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41942289
156Prolactin signaling pathway_Homo sapiens_hsa049170.41361001
157Circadian entrainment_Homo sapiens_hsa047130.40688203
158Long-term depression_Homo sapiens_hsa047300.39577176
159Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38967683
160Calcium signaling pathway_Homo sapiens_hsa040200.38551938
161Bladder cancer_Homo sapiens_hsa052190.37506313
162Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36652358
163Morphine addiction_Homo sapiens_hsa050320.35811273
164Glutamatergic synapse_Homo sapiens_hsa047240.34862641
165Endocytosis_Homo sapiens_hsa041440.34709206
166Phagosome_Homo sapiens_hsa041450.34535122
167Platelet activation_Homo sapiens_hsa046110.32820965
168Prion diseases_Homo sapiens_hsa050200.31916917
169FoxO signaling pathway_Homo sapiens_hsa040680.31657787
170Sphingolipid signaling pathway_Homo sapiens_hsa040710.29728007
171Fructose and mannose metabolism_Homo sapiens_hsa000510.28469324
172Choline metabolism in cancer_Homo sapiens_hsa052310.28330736
173Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.24160118
174Galactose metabolism_Homo sapiens_hsa000520.22899355
175VEGF signaling pathway_Homo sapiens_hsa043700.21018127
176Central carbon metabolism in cancer_Homo sapiens_hsa052300.19684796
177Lysine degradation_Homo sapiens_hsa003100.18694035
178N-Glycan biosynthesis_Homo sapiens_hsa005100.17792742
179Phospholipase D signaling pathway_Homo sapiens_hsa040720.17575430

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