BTN3A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The butyrophilin (BTN) genes are a group of major histocompatibility complex (MHC)-associated genes that encode type I membrane proteins with 2 extracellular immunoglobulin (Ig) domains and an intracellular B30.2 (PRYSPRY) domain. Three subfamilies of human BTN genes are located in the MHC class I region: the single-copy BTN1A1 gene (MIM 601610) and the BTN2 (e.g., BTN2A1; MIM 613590) and BTN3 (e.g., BNT3A1) genes, which have undergone tandem duplication, resulting in 3 copies of each (summary by Smith et al., 2010 [PubMed 20208008]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)7.01796248
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)7.01796248
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.87045444
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.63937377
5positive regulation of gamma-delta T cell activation (GO:0046645)6.50055232
6antigen processing and presentation of endogenous antigen (GO:0019883)6.34697962
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.12974042
8regulation of B cell receptor signaling pathway (GO:0050855)5.28951490
9positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.04339038
10regulation of gamma-delta T cell activation (GO:0046643)4.78672917
11modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.72969729
12positive regulation by organism of defense response of other organism involved in symbiotic interact4.72969729
13modulation by symbiont of host immune response (GO:0052553)4.72969729
14positive regulation by symbiont of host defense response (GO:0052509)4.72969729
15modulation by symbiont of host defense response (GO:0052031)4.72969729
16modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.72969729
17negative T cell selection (GO:0043383)4.69632327
18negative thymic T cell selection (GO:0045060)4.68748826
19regulation of gamma-delta T cell differentiation (GO:0045586)4.62970005
20detection of other organism (GO:0098543)4.56679594
21response to interleukin-15 (GO:0070672)4.54200586
22detection of bacterium (GO:0016045)4.45893132
23negative regulation of lymphocyte mediated immunity (GO:0002707)4.37721617
24leukocyte aggregation (GO:0070486)4.36736805
25positive thymic T cell selection (GO:0045059)4.35498875
26cellular response to interleukin-15 (GO:0071350)4.13093884
27positive T cell selection (GO:0043368)4.09172575
28macrophage activation involved in immune response (GO:0002281)4.01026099
29negative regulation of T cell mediated immunity (GO:0002710)4.00816463
30neutrophil activation involved in immune response (GO:0002283)3.93843028
31type I interferon signaling pathway (GO:0060337)3.91130571
32cellular response to type I interferon (GO:0071357)3.91130571
33response to type I interferon (GO:0034340)3.90453875
34antigen processing and presentation via MHC class Ib (GO:0002475)3.84895285
35detection of external biotic stimulus (GO:0098581)3.84287800
36negative regulation of leukocyte mediated immunity (GO:0002704)3.84167785
37T cell selection (GO:0045058)3.83694391
38B cell receptor signaling pathway (GO:0050853)3.79580014
39regulation of T cell tolerance induction (GO:0002664)3.78778769
40cellular extravasation (GO:0045123)3.73947031
41thymic T cell selection (GO:0045061)3.70862663
42T cell migration (GO:0072678)3.69959617
43regulation of regulatory T cell differentiation (GO:0045589)3.68122815
44negative regulation of interleukin-12 production (GO:0032695)3.63790089
45positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.61333535
46immunoglobulin mediated immune response (GO:0016064)3.61215750
47regulation of B cell differentiation (GO:0045577)3.60288954
48regulation of interferon-beta biosynthetic process (GO:0045357)3.58177656
49regulation of tolerance induction (GO:0002643)3.54801518
50microglial cell activation (GO:0001774)3.51124538
51regulation of alpha-beta T cell proliferation (GO:0046640)3.49038997
52regulation of T cell mediated cytotoxicity (GO:0001914)3.46433035
53tolerance induction (GO:0002507)3.46123833
54detection of molecule of bacterial origin (GO:0032490)3.46055356
55positive regulation of B cell differentiation (GO:0045579)3.41471860
56interferon-gamma-mediated signaling pathway (GO:0060333)3.39068134
57positive regulation of granulocyte differentiation (GO:0030854)3.38565315
58neutrophil activation (GO:0042119)3.36997009
59negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.34078392
60positive regulation of T cell mediated cytotoxicity (GO:0001916)3.33762399
61positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.32777572
62response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.32717117
63response to host immune response (GO:0052572)3.32717117
64detection of biotic stimulus (GO:0009595)3.32580041
65regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.32560117
66regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.28204282
67regulation of natural killer cell mediated immunity (GO:0002715)3.28204282
68respiratory burst (GO:0045730)3.26087293
69positive regulation of tolerance induction (GO:0002645)3.22513730
70response to peptidoglycan (GO:0032494)3.19862723
71regulation of dendritic cell antigen processing and presentation (GO:0002604)3.17423661
72negative regulation of innate immune response (GO:0045824)3.16695017
73response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.16072212
74response to host (GO:0075136)3.16072212
75response to host defenses (GO:0052200)3.16072212
76myeloid cell activation involved in immune response (GO:0002275)3.14031151
77positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.09946342
78negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.09248526
79response to muramyl dipeptide (GO:0032495)3.02720293
80negative regulation of T-helper cell differentiation (GO:0045623)3.02118768
81negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.02118768
82granulocyte activation (GO:0036230)2.99274804
83defense response to protozoan (GO:0042832)2.99001494
84regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.98693579
85macrophage activation (GO:0042116)2.98183186
86dendritic cell migration (GO:0036336)2.97136341
87* antigen receptor-mediated signaling pathway (GO:0050851)2.96054160
88dendritic cell chemotaxis (GO:0002407)2.94592645
89neutrophil mediated immunity (GO:0002446)2.94138419
90regulation of leukocyte mediated cytotoxicity (GO:0001910)2.93693091
91* activated T cell proliferation (GO:0050798)2.92242236
92germinal center formation (GO:0002467)2.89912870
93B cell mediated immunity (GO:0019724)2.89728917
94regulation of antigen processing and presentation (GO:0002577)2.89632257
95leukocyte migration involved in inflammatory response (GO:0002523)2.86760341
96negative regulation of erythrocyte differentiation (GO:0045647)2.86357420
97negative regulation of adaptive immune response (GO:0002820)2.85417519
98interferon-gamma production (GO:0032609)2.84910697
99positive regulation of antigen processing and presentation (GO:0002579)2.83299382
100negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.83022317

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.39652530
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.00851406
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.86995610
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.12189799
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.91426463
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.83950892
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.48063516
8RUNX_20019798_ChIP-Seq_JUKART_Human3.35255561
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.08754952
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.98358493
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.94894543
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.91921789
13MYB_26560356_Chip-Seq_TH2_Human2.79000557
14FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.59716750
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.54149959
16SMAD_19615063_ChIP-ChIP_OVARY_Human2.44927290
17MAF_26560356_Chip-Seq_TH1_Human2.44555636
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.38677347
19SPI1_23547873_ChIP-Seq_NB4_Human2.34231429
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.34172742
21MYB_26560356_Chip-Seq_TH1_Human2.32076479
22STAT4_19710469_ChIP-ChIP_TH1__Mouse2.27994821
23SCL_19346495_ChIP-Seq_HPC-7_Human2.25563923
24SPI1_23127762_ChIP-Seq_K562_Human2.22954300
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.22562191
26E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.20822266
27VDR_24763502_ChIP-Seq_THP-1_Human2.19920967
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.15956547
29UTX_26944678_Chip-Seq_JUKART_Human2.13283194
30VDR_21846776_ChIP-Seq_THP-1_Human2.10054193
31RUNX1_22412390_ChIP-Seq_EML_Mouse2.04059297
32MYC_22102868_ChIP-Seq_BL_Human2.01080299
33GATA3_27048872_Chip-Seq_THYMUS_Human2.00238833
34BRD4_27068464_Chip-Seq_AML-cells_Mouse1.88995276
35MAF_26560356_Chip-Seq_TH2_Human1.77854804
36TCF7_22412390_ChIP-Seq_EML_Mouse1.71230591
37RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.67110607
38VDR_24787735_ChIP-Seq_THP-1_Human1.66151356
39KDM2B_26808549_Chip-Seq_SUP-B15_Human1.66096372
40Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.64639048
41MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.62316883
42GATA1_22025678_ChIP-Seq_K562_Human1.61611230
43NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.57656967
44GATA3_26560356_Chip-Seq_TH2_Human1.56351849
45NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.53169316
46KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.52740774
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.51665403
48KDM2B_26808549_Chip-Seq_DND41_Human1.50372801
49GATA1_19941827_ChIP-Seq_MEL_Mouse1.47129865
50EGR1_19374776_ChIP-ChIP_THP-1_Human1.43469279
51LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.41520193
52KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.40704953
53CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36333599
54LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.34655653
55TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.30814654
56ELF1_17652178_ChIP-ChIP_JURKAT_Human1.29948979
57GATA2_22383799_ChIP-Seq_G1ME_Mouse1.28323647
58PU_27001747_Chip-Seq_BMDM_Mouse1.26454512
59THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.25949397
60SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.22413872
61GATA1_19941826_ChIP-Seq_K562_Human1.20585518
62RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.18168432
63FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17017918
64GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16796937
65BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.16072454
66GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.15141841
67PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14867986
68GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14364728
69PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13677410
70GATA2_21666600_ChIP-Seq_HMVEC_Human1.12515935
71SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12229644
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11522555
73SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.10906790
74PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10603579
75KDM2B_26808549_Chip-Seq_JURKAT_Human1.08663221
76CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07984526
77CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07951479
78CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07659586
79GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06237918
80PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03503077
81ELK3_25401928_ChIP-Seq_HUVEC_Human1.01058804
82STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.00350954
83GATA2_19941826_ChIP-Seq_K562_Human0.97129650
84NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.94530665
85SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93116879
86PU.1_20513432_ChIP-Seq_Bcells_Mouse0.92746824
87STAT6_21828071_ChIP-Seq_BEAS2B_Human0.92341849
88IKZF1_21737484_ChIP-ChIP_HCT116_Human0.90319746
89* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.90118970
90BCL6_27268052_Chip-Seq_Bcells_Human0.87957899
91CIITA_25753668_ChIP-Seq_RAJI_Human0.86064752
92CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.83598734
93STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.80534130
94SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.80401326
95BCOR_27268052_Chip-Seq_Bcells_Human0.77670130
96* SMRT_27268052_Chip-Seq_Bcells_Human0.77568471
97NCOR1_26117541_ChIP-Seq_K562_Human0.76086738
98LXR_22292898_ChIP-Seq_THP-1_Human0.75839041
99RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75138118
100GATA1_19941827_ChIP-Seq_MEL86_Mouse0.71777648

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.65488626
2MP0001835_abnormal_antigen_presentation4.10346097
3MP0003436_decreased_susceptibility_to3.92234402
4MP0005671_abnormal_response_to3.43504465
5MP0003763_abnormal_thymus_physiology3.34875539
6MP0001800_abnormal_humoral_immune3.25579809
7MP0003303_peritoneal_inflammation3.05011675
8MP0000685_abnormal_immune_system2.99997455
9MP0005387_immune_system_phenotype2.94607237
10MP0001790_abnormal_immune_system2.94607237
11MP0005000_abnormal_immune_tolerance2.90663433
12MP0005025_abnormal_response_to2.83894870
13MP0002419_abnormal_innate_immunity2.81597957
14MP0009785_altered_susceptibility_to2.77850316
15MP0002723_abnormal_immune_serum2.72891440
16MP0002420_abnormal_adaptive_immunity2.64635047
17MP0001819_abnormal_immune_cell2.61780823
18MP0002452_abnormal_antigen_presenting2.61739388
19MP0006082_CNS_inflammation2.50563049
20MP0003300_gastrointestinal_ulcer2.42291890
21MP0002405_respiratory_system_inflammati2.12267136
22MP0010155_abnormal_intestine_physiology2.12189410
23MP0002398_abnormal_bone_marrow2.11494457
24MP0002148_abnormal_hypersensitivity_rea2.11061362
25MP0000716_abnormal_immune_system2.04129011
26MP0003866_abnormal_defecation2.01039273
27MP0001533_abnormal_skeleton_physiology1.96764051
28MP0005464_abnormal_platelet_physiology1.96663414
29MP0009333_abnormal_splenocyte_physiolog1.93108637
30MP0008260_abnormal_autophagy1.81825476
31MP0003191_abnormal_cellular_cholesterol1.80782170
32MP0004947_skin_inflammation1.79854128
33MP0001845_abnormal_inflammatory_respons1.78614070
34MP0002396_abnormal_hematopoietic_system1.78605063
35MP0000689_abnormal_spleen_morphology1.76889005
36MP0000703_abnormal_thymus_morphology1.75202805
37MP0002722_abnormal_immune_system1.71890576
38MP0000465_gastrointestinal_hemorrhage1.70361520
39MP0002166_altered_tumor_susceptibility1.67520320
40MP0004381_abnormal_hair_follicle1.63380853
41MP0003172_abnormal_lysosome_physiology1.63165669
42MP0002429_abnormal_blood_cell1.59294540
43MP0001873_stomach_inflammation1.48917312
44MP0002132_abnormal_respiratory_system1.47126755
45MP0003828_pulmonary_edema1.42498133
46MP0008469_abnormal_protein_level1.40755854
47MP0004883_abnormal_blood_vessel1.40462886
48MP0001851_eye_inflammation1.37216047
49MP0005310_abnormal_salivary_gland1.36235395
50MP0003183_abnormal_peptide_metabolism1.34987981
51MP0000858_altered_metastatic_potential1.33751457
52MP0009764_decreased_sensitivity_to1.27640483
53MP0005451_abnormal_body_composition1.26611620
54MP0002998_abnormal_bone_remodeling1.18279122
55MP0005075_abnormal_melanosome_morpholog1.16160796
56MP0002933_joint_inflammation1.13723769
57MP0002277_abnormal_respiratory_mucosa1.09130774
58MP0009278_abnormal_bone_marrow1.07825102
59MP0002006_tumorigenesis1.05687172
60MP0005164_abnormal_response_to1.03864587
61MP0003690_abnormal_glial_cell1.01223522
62MP0001663_abnormal_digestive_system0.95113529
63MP0005166_decreased_susceptibility_to0.93739054
64MP0003045_fibrosis0.93625958
65MP0001853_heart_inflammation0.91303590
66MP0009763_increased_sensitivity_to0.90552908
67MP0002009_preneoplasia0.90084391
68MP0005397_hematopoietic_system_phenotyp0.88487400
69MP0001545_abnormal_hematopoietic_system0.88487400
70MP0003448_altered_tumor_morphology0.87680575
71MP0001986_abnormal_taste_sensitivity0.87230730
72MP0002138_abnormal_hepatobiliary_system0.86449065
73MP0000604_amyloidosis0.86038317
74MP0004808_abnormal_hematopoietic_stem0.80234071
75MP0000015_abnormal_ear_pigmentation0.78924336
76MP0003656_abnormal_erythrocyte_physiolo0.78362105
77MP0005390_skeleton_phenotype0.76731170
78MP0000249_abnormal_blood_vessel0.76227622
79MP0003075_altered_response_to0.75542743
80MP0000569_abnormal_digit_pigmentation0.73943057
81MP0003091_abnormal_cell_migration0.71668372
82MP0000490_abnormal_crypts_of0.71055356
83MP0004510_myositis0.70334379
84MP0004130_abnormal_muscle_cell0.70255619
85MP0009765_abnormal_xenobiotic_induced0.68706788
86MP0005058_abnormal_lysosome_morphology0.68048276
87MP0003252_abnormal_bile_duct0.67680626
88MP0001958_emphysema0.64876578
89MP0008004_abnormal_stomach_pH0.62657400
90MP0003795_abnormal_bone_structure0.61060894
91MP0008874_decreased_physiological_sensi0.60223956
92MP0002019_abnormal_tumor_incidence0.56450433
93MP0000343_altered_response_to0.56417572
94MP0004484_altered_response_of0.55957679
95MP0003221_abnormal_cardiomyocyte_apopto0.55305636
96MP0005388_respiratory_system_phenotype0.53140820
97MP0002133_abnormal_respiratory_system0.53140820
98MP0005381_digestive/alimentary_phenotyp0.51788347
99MP0000609_abnormal_liver_physiology0.49611080
100MP0005085_abnormal_gallbladder_physiolo0.48613308

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.53317727
2Recurrent bacterial skin infections (HP:0005406)5.37753298
3Myositis (HP:0100614)5.37179485
4Recurrent abscess formation (HP:0002722)5.29530253
5Orchitis (HP:0100796)4.86400147
6Elevated erythrocyte sedimentation rate (HP:0003565)4.81772884
7Optic neuritis (HP:0100653)4.70176182
8Retrobulbar optic neuritis (HP:0100654)4.70176182
9T lymphocytopenia (HP:0005403)4.67215257
10Abnormality of macrophages (HP:0004311)4.47210868
11Abnormal delayed hypersensitivity skin test (HP:0002963)4.44940447
12Abnormality of T cell number (HP:0011839)4.44021506
13Recurrent fungal infections (HP:0002841)4.43985092
14Gastrointestinal infarctions (HP:0005244)4.41377257
15Stomatitis (HP:0010280)4.38853042
16Recurrent gram-negative bacterial infections (HP:0005420)4.21811339
17Meningitis (HP:0001287)3.96596789
18Mediastinal lymphadenopathy (HP:0100721)3.90889433
19Recurrent skin infections (HP:0001581)3.83959536
20Recurrent cutaneous fungal infections (HP:0011370)3.81685800
21Chronic mucocutaneous candidiasis (HP:0002728)3.81685800
22Encephalitis (HP:0002383)3.79099477
23Pustule (HP:0200039)3.68087603
24Vasculitis (HP:0002633)3.67178910
25Spontaneous hematomas (HP:0007420)3.66065647
26Abnormality of T cells (HP:0002843)3.55739097
27Panhypogammaglobulinemia (HP:0003139)3.54627905
28Chronic obstructive pulmonary disease (HP:0006510)3.54171840
29Obstructive lung disease (HP:0006536)3.54171840
30Increased IgE level (HP:0003212)3.47160959
31Keratoconjunctivitis sicca (HP:0001097)3.39172897
32Gingivitis (HP:0000230)3.39010574
33Recurrent viral infections (HP:0004429)3.32124350
34Prolonged bleeding time (HP:0003010)3.28496690
35Chest pain (HP:0100749)3.26805452
36Pulmonary infiltrates (HP:0002113)3.22170490
37Keratoconjunctivitis (HP:0001096)3.16797697
38Inflammation of the large intestine (HP:0002037)3.14965456
39Leukocytosis (HP:0001974)3.12160472
40Hemoptysis (HP:0002105)3.06764880
41Gastrointestinal inflammation (HP:0004386)3.03566409
42Recurrent bronchitis (HP:0002837)2.99921350
43Granulocytopenia (HP:0001913)2.96097196
44Gingival bleeding (HP:0000225)2.95860822
45Urticaria (HP:0001025)2.95833537
46Hypochromic microcytic anemia (HP:0004840)2.94114806
47Hypochromic anemia (HP:0001931)2.88793703
48Colitis (HP:0002583)2.86169988
49Cellulitis (HP:0100658)2.86035595
50Epistaxis (HP:0000421)2.81335247
51Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.76720117
52Increased IgM level (HP:0003496)2.76676956
53Abnormality of T cell physiology (HP:0011840)2.73774877
54Lymphopenia (HP:0001888)2.71594729
55Eosinophilia (HP:0001880)2.71282408
56Autoimmune hemolytic anemia (HP:0001890)2.71034836
57Arterial thrombosis (HP:0004420)2.69085816
58Pulmonary embolism (HP:0002204)2.67308724
59Agammaglobulinemia (HP:0004432)2.66972861
60Papilledema (HP:0001085)2.64894364
61Abnormality of cells of the lymphoid lineage (HP:0012140)2.59686206
62Peritonitis (HP:0002586)2.57873247
63Abnormality of eosinophils (HP:0001879)2.47451198
64Severe combined immunodeficiency (HP:0004430)2.42584201
65Chronic otitis media (HP:0000389)2.41382890
66Osteomyelitis (HP:0002754)2.41083209
67Anorexia (HP:0002039)2.40859090
68Hypergammaglobulinemia (HP:0010702)2.39074822
69IgM deficiency (HP:0002850)2.37499791
70Chronic diarrhea (HP:0002028)2.37425212
71IgG deficiency (HP:0004315)2.35422735
72Abnormality of the pleura (HP:0002103)2.32610562
73Episodic fever (HP:0001954)2.32608766
74Microcytic anemia (HP:0001935)2.25116603
75Papilloma (HP:0012740)2.24182019
76Verrucae (HP:0200043)2.24182019
77Gangrene (HP:0100758)2.23683406
78Sepsis (HP:0100806)2.22050655
79Abnormality of the peritoneum (HP:0002585)2.21416251
80Viral hepatitis (HP:0006562)2.17678917
81Joint swelling (HP:0001386)2.13409767
82Slow saccadic eye movements (HP:0000514)2.13348310
83Acute hepatic failure (HP:0006554)2.10437614
84Glomerulopathy (HP:0100820)2.10023645
85Gastrointestinal stroma tumor (HP:0100723)2.07622820
86Skin ulcer (HP:0200042)2.06934116
87Autoimmune thrombocytopenia (HP:0001973)2.05390660
88Stomach cancer (HP:0012126)2.02597057
89Abnormality of the endocardium (HP:0004306)1.96745844
90Petechiae (HP:0000967)1.95258352
91Nasal polyposis (HP:0100582)1.93815496
92Amyloidosis (HP:0011034)1.93249812
93Skin rash (HP:0000988)1.92072847
94Abnormality of the fingertips (HP:0001211)1.89972753
95Keratitis (HP:0000491)1.89437815
96Recurrent sinusitis (HP:0011108)1.88494653
97Premature loss of primary teeth (HP:0006323)1.86914678
98Restrictive lung disease (HP:0002091)1.86607461
99Subacute progressive viral hepatitis (HP:0006572)1.86192077
100Purpura (HP:0000979)1.84535668

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.23920358
2RIPK44.10488836
3TYK23.11948773
4BLK2.83349921
5TXK2.78052509
6FES2.59099360
7CSK2.50976288
8TAOK32.48901763
9PRPF4B2.33746903
10GRK62.30731301
11IRAK42.28234428
12ZAP702.22447902
13ERN12.19558080
14MAP2K32.11718700
15JAK32.10354538
16IKBKE2.05870465
17BTK2.02138241
18JAK11.99453097
19TNK21.96316377
20MAP3K141.95876902
21EPHB11.89859295
22SYK1.82183846
23MAP3K131.71438881
24ITK1.71131046
25HCK1.65528566
26FGFR41.51451803
27LCK1.42279834
28TBK11.39093274
29TEC1.37297246
30LYN1.36928391
31KIT1.36029723
32FGR1.35846674
33JAK21.32670163
34FGFR31.27770208
35MAP3K31.21356120
36CSF1R1.20155475
37SIK31.16370479
38MARK31.08684580
39NLK1.07723292
40TAOK11.06225010
41MAP3K11.05923589
42BMPR20.98053759
43KSR20.96605728
44YES10.95427727
45IKBKB0.94107895
46CAMKK20.91403073
47MARK20.91280905
48MAP3K110.88620732
49EPHA30.86863941
50PDK10.84927714
51IRAK10.84187309
52STK100.83264590
53SIK20.79611292
54CDC42BPA0.79220586
55PTK60.79150800
56MAP3K70.78744555
57PRKCQ0.77329732
58HIPK20.76345023
59TRIB30.74553724
60TGFBR20.72367160
61CAMKK10.71846293
62PRKD20.70899616
63MAP3K100.70196850
64MAPK70.69829181
65MAP3K60.69751503
66PTK2B0.68726136
67PIK3CG0.68276696
68MATK0.66394247
69LRRK20.66177499
70FYN0.65741155
71MAPK120.63932183
72PIM10.63090278
73MAP3K20.61180610
74PDPK10.55282653
75MAPK110.55237643
76ACVR1B0.54785676
77STK380.54234151
78RET0.53774031
79DYRK1B0.53104055
80SGK30.47473855
81STK110.44264142
82MAP2K60.43937853
83CDK40.42664487
84RIPK10.42204933
85SGK20.41093485
86MELK0.39353755
87TRPM70.37270517
88GRK70.37196274
89MAP3K50.36140060
90PRKCH0.35650522
91PDGFRB0.33442247
92RAF10.33368913
93MAP2K20.33274216
94TAOK20.33249363
95SMG10.32531675
96CDK190.31027465
97WNK10.30771166
98TYRO30.30764480
99IRAK20.30052630
100CDK60.29567976

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.03164788
2Graft-versus-host disease_Homo sapiens_hsa053322.88248726
3Allograft rejection_Homo sapiens_hsa053302.86668994
4Leishmaniasis_Homo sapiens_hsa051402.74646242
5Autoimmune thyroid disease_Homo sapiens_hsa053202.73959525
6Staphylococcus aureus infection_Homo sapiens_hsa051502.62397199
7Osteoclast differentiation_Homo sapiens_hsa043802.56100411
8Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.39921792
9B cell receptor signaling pathway_Homo sapiens_hsa046622.30276221
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.14489692
11T cell receptor signaling pathway_Homo sapiens_hsa046602.11426276
12Type I diabetes mellitus_Homo sapiens_hsa049402.05850316
13Antigen processing and presentation_Homo sapiens_hsa046121.99458698
14Measles_Homo sapiens_hsa051621.95441868
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.85469343
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.82736446
17Tuberculosis_Homo sapiens_hsa051521.81174649
18Hematopoietic cell lineage_Homo sapiens_hsa046401.78771693
19Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.77830254
20Viral myocarditis_Homo sapiens_hsa054161.77144534
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.76258965
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.71648276
23Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.63237692
24Acute myeloid leukemia_Homo sapiens_hsa052211.61124085
25Asthma_Homo sapiens_hsa053101.59988558
26Chemokine signaling pathway_Homo sapiens_hsa040621.57404775
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.56818515
28Toxoplasmosis_Homo sapiens_hsa051451.54181904
29Influenza A_Homo sapiens_hsa051641.53062054
30Herpes simplex infection_Homo sapiens_hsa051681.47781456
31Jak-STAT signaling pathway_Homo sapiens_hsa046301.47128330
32Malaria_Homo sapiens_hsa051441.47068731
33TNF signaling pathway_Homo sapiens_hsa046681.26106462
34Non-small cell lung cancer_Homo sapiens_hsa052231.23362754
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.22559337
36Platelet activation_Homo sapiens_hsa046111.19375324
37Hepatitis C_Homo sapiens_hsa051601.15257235
38Leukocyte transendothelial migration_Homo sapiens_hsa046701.14044233
39Hepatitis B_Homo sapiens_hsa051611.13159309
40Other glycan degradation_Homo sapiens_hsa005111.06246540
41Phagosome_Homo sapiens_hsa041451.04265151
42Pancreatic cancer_Homo sapiens_hsa052121.01871269
43Legionellosis_Homo sapiens_hsa051341.00694741
44African trypanosomiasis_Homo sapiens_hsa051430.99480026
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.97576607
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.97367093
47Pertussis_Homo sapiens_hsa051330.94591931
48Apoptosis_Homo sapiens_hsa042100.90218961
49VEGF signaling pathway_Homo sapiens_hsa043700.88143059
50Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.87756838
51Rheumatoid arthritis_Homo sapiens_hsa053230.87176978
52Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.86871229
53Chronic myeloid leukemia_Homo sapiens_hsa052200.85205244
54Prolactin signaling pathway_Homo sapiens_hsa049170.84058998
55Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76853412
56Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76841789
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74135957
58FoxO signaling pathway_Homo sapiens_hsa040680.73793599
59Shigellosis_Homo sapiens_hsa051310.71983018
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.71409453
61Dorso-ventral axis formation_Homo sapiens_hsa043200.70963966
62Choline metabolism in cancer_Homo sapiens_hsa052310.69696489
63Renal cell carcinoma_Homo sapiens_hsa052110.68601799
64Epstein-Barr virus infection_Homo sapiens_hsa051690.65443637
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.65327074
66Adipocytokine signaling pathway_Homo sapiens_hsa049200.64381670
67Endocytosis_Homo sapiens_hsa041440.63700072
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63188023
69HTLV-I infection_Homo sapiens_hsa051660.61651834
70Endometrial cancer_Homo sapiens_hsa052130.58984909
71Notch signaling pathway_Homo sapiens_hsa043300.57046169
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.57043808
73Viral carcinogenesis_Homo sapiens_hsa052030.56187643
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55965655
75Inositol phosphate metabolism_Homo sapiens_hsa005620.55563839
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54876597
77Salmonella infection_Homo sapiens_hsa051320.54634359
78Insulin resistance_Homo sapiens_hsa049310.54184367
79Colorectal cancer_Homo sapiens_hsa052100.53323612
80GnRH signaling pathway_Homo sapiens_hsa049120.52867755
81Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.51352836
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.51030162
83mTOR signaling pathway_Homo sapiens_hsa041500.50120571
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49264997
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45366356
86Lysosome_Homo sapiens_hsa041420.41237895
87MAPK signaling pathway_Homo sapiens_hsa040100.41230600
88HIF-1 signaling pathway_Homo sapiens_hsa040660.38372229
89Prostate cancer_Homo sapiens_hsa052150.34985812
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34863347
91Amoebiasis_Homo sapiens_hsa051460.34519858
92Rap1 signaling pathway_Homo sapiens_hsa040150.32584796
93ErbB signaling pathway_Homo sapiens_hsa040120.31626376
94Ras signaling pathway_Homo sapiens_hsa040140.31249880
95Glycosaminoglycan degradation_Homo sapiens_hsa005310.30004118
96Regulation of autophagy_Homo sapiens_hsa041400.29592927
97Type II diabetes mellitus_Homo sapiens_hsa049300.29024600
98Complement and coagulation cascades_Homo sapiens_hsa046100.27690929
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26834356
100ABC transporters_Homo sapiens_hsa020100.25586887

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