BTN3A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the immunoglobulin superfamily, which resides in the juxta-telomeric region of the major histocompatability class 1 locus and is clustered with the other family members on chromosome 6. The encoded protein may be involved in the adaptive immune response. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.07501004
2negative regulation of cell killing (GO:0031342)6.07501004
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.82942677
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.78914642
5antigen processing and presentation of endogenous antigen (GO:0019883)5.48503555
6positive regulation of gamma-delta T cell activation (GO:0046645)5.34934971
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.32114950
8activated T cell proliferation (GO:0050798)5.23279200
9regulation of B cell receptor signaling pathway (GO:0050855)4.56284307
10positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.54636740
11negative T cell selection (GO:0043383)4.53072400
12negative thymic T cell selection (GO:0045060)4.47345405
13regulation of regulatory T cell differentiation (GO:0045589)4.23027464
14regulation of gamma-delta T cell activation (GO:0046643)4.14796732
15regulation of gamma-delta T cell differentiation (GO:0045586)4.12659350
16cellular response to interleukin-15 (GO:0071350)4.05982452
17response to interleukin-15 (GO:0070672)4.00924870
18cellular response to exogenous dsRNA (GO:0071360)3.81926596
19positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.76027448
20negative regulation of lymphocyte mediated immunity (GO:0002707)3.72050343
21regulation of germinal center formation (GO:0002634)3.70212128
22positive thymic T cell selection (GO:0045059)3.68460036
23negative regulation of T cell mediated immunity (GO:0002710)3.67878846
24regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.67013979
25regulation of natural killer cell mediated immunity (GO:0002715)3.67013979
26regulation of alpha-beta T cell proliferation (GO:0046640)3.61237784
27regulation of T cell mediated cytotoxicity (GO:0001914)3.59692453
28tolerance induction (GO:0002507)3.58259962
29positive T cell selection (GO:0043368)3.55506195
30positive regulation of T cell mediated cytotoxicity (GO:0001916)3.51181832
31interferon-gamma production (GO:0032609)3.49209464
32T cell migration (GO:0072678)3.47590985
33negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.37728931
34regulation of leukocyte mediated cytotoxicity (GO:0001910)3.37502481
35DNA deamination (GO:0045006)3.37481588
36response to type I interferon (GO:0034340)3.36605325
37leukocyte aggregation (GO:0070486)3.31512467
38negative regulation of T-helper cell differentiation (GO:0045623)3.30166515
39negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.30166515
40type I interferon signaling pathway (GO:0060337)3.28937210
41cellular response to type I interferon (GO:0071357)3.28937210
42T cell selection (GO:0045058)3.27510191
43positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.27492483
44positive regulation of defense response to virus by host (GO:0002230)3.26602315
45interferon-gamma-mediated signaling pathway (GO:0060333)3.23490735
46modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.22709381
47positive regulation by organism of defense response of other organism involved in symbiotic interact3.22709381
48modulation by symbiont of host immune response (GO:0052553)3.22709381
49positive regulation by symbiont of host defense response (GO:0052509)3.22709381
50modulation by symbiont of host defense response (GO:0052031)3.22709381
51modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.22709381
52sulfation (GO:0051923)3.18359398
53regulation of T cell tolerance induction (GO:0002664)3.18080834
54thymic T cell selection (GO:0045061)3.17048234
55detection of bacterium (GO:0016045)3.16119616
56B cell receptor signaling pathway (GO:0050853)3.15010731
57immunoglobulin mediated immune response (GO:0016064)3.13241437
58antigen processing and presentation via MHC class Ib (GO:0002475)3.13174438
59detection of other organism (GO:0098543)3.12803349
60negative regulation of leukocyte mediated immunity (GO:0002704)3.10683069
61positive regulation of antigen processing and presentation (GO:0002579)3.08670370
62regulation of cell killing (GO:0031341)3.05846153
63neutrophil activation involved in immune response (GO:0002283)3.03646412
64positive regulation of interferon-alpha production (GO:0032727)3.03400645
65mast cell activation (GO:0045576)3.00556103
66positive regulation of granulocyte differentiation (GO:0030854)2.99771712
67regulation of B cell differentiation (GO:0045577)2.98202762
68positive regulation of natural killer cell mediated immunity (GO:0002717)2.96849928
69regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.96086721
70regulation of antigen processing and presentation (GO:0002577)2.94699320
71positive regulation of cell killing (GO:0031343)2.93459841
72regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.92812590
73regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.92055251
74positive regulation of mast cell activation (GO:0033005)2.91803889
75positive regulation of alpha-beta T cell proliferation (GO:0046641)2.91395014
76cytidine catabolic process (GO:0006216)2.91145796
77cytidine deamination (GO:0009972)2.91145796
78cytidine metabolic process (GO:0046087)2.91145796
79regulation of tolerance induction (GO:0002643)2.86979823
80macrophage activation involved in immune response (GO:0002281)2.84397792
81regulation of interferon-alpha production (GO:0032647)2.84373504
82negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.84226978
83regulation of interferon-beta biosynthetic process (GO:0045357)2.84140166
84antigen receptor-mediated signaling pathway (GO:0050851)2.83274763
85microglial cell activation (GO:0001774)2.82642340
86negative regulation of alpha-beta T cell activation (GO:0046636)2.81721415
87neutrophil activation (GO:0042119)2.80487912
88cellular extravasation (GO:0045123)2.79251032
89dendritic cell chemotaxis (GO:0002407)2.78813629
90positive regulation of B cell differentiation (GO:0045579)2.78180322
91positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.77748368
92negative regulation of innate immune response (GO:0045824)2.76883345
93negative regulation of interleukin-12 production (GO:0032695)2.72116678
94T cell receptor signaling pathway (GO:0050852)2.71082746
95response to interferon-beta (GO:0035456)2.68442261
96regulation of mast cell activation (GO:0033003)2.66382579
97positive regulation of tolerance induction (GO:0002645)2.66285728
98regulation of T cell mediated immunity (GO:0002709)2.66013502
99pyrimidine ribonucleoside catabolic process (GO:0046133)2.65740177
100dendritic cell migration (GO:0036336)2.64921404

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.93860493
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.81525449
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.18538592
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.10614980
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.54492708
6* RUNX_20019798_ChIP-Seq_JUKART_Human3.11216357
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.68209380
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.45053058
9EZH2_22144423_ChIP-Seq_EOC_Human2.32353512
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.30551532
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.19048856
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.18867101
13MYB_26560356_Chip-Seq_TH2_Human2.17701083
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.14749927
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.13279997
16SCL_19346495_ChIP-Seq_HPC-7_Human2.13030140
17RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.99843853
18SMAD_19615063_ChIP-ChIP_OVARY_Human1.97539536
19GATA3_27048872_Chip-Seq_THYMUS_Human1.91183508
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.85392320
21FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.83216036
22LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.72992215
23MYB_26560356_Chip-Seq_TH1_Human1.70863228
24* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.70095551
25STAT4_19710469_ChIP-ChIP_TH1__Mouse1.70067220
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.65111491
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.64971169
28GATA3_26560356_Chip-Seq_TH2_Human1.60457016
29SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.55479103
30BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.52782207
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.52648537
32VDR_24787735_ChIP-Seq_THP-1_Human1.52355770
33UTX_26944678_Chip-Seq_JUKART_Human1.43231242
34MAF_26560356_Chip-Seq_TH1_Human1.40834511
35GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.36704764
36VDR_24763502_ChIP-Seq_THP-1_Human1.34509802
37SPI1_23547873_ChIP-Seq_NB4_Human1.30701414
38SPI1_23127762_ChIP-Seq_K562_Human1.27628614
39BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.24004666
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20105089
41LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.19745773
42EGR1_23403033_ChIP-Seq_LIVER_Mouse1.15411730
43RUNX1_22412390_ChIP-Seq_EML_Mouse1.14039262
44NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.12612857
45SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11060396
46PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10887914
47CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.09958032
48SMRT_27268052_Chip-Seq_Bcells_Human1.09377100
49IKZF1_21737484_ChIP-ChIP_HCT116_Human1.09131165
50VDR_22108803_ChIP-Seq_LS180_Human1.08977878
51MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.08951734
52* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.08155357
53* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07586299
54RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.07194975
55PRDM14_20953172_ChIP-Seq_ESCs_Human1.04852660
56ZFP57_27257070_Chip-Seq_ESCs_Mouse1.04475619
57IRF1_19129219_ChIP-ChIP_H3396_Human1.02674163
58ZNF274_21170338_ChIP-Seq_K562_Hela1.01845910
59GATA1_22025678_ChIP-Seq_K562_Human1.01210782
60MAF_26560356_Chip-Seq_TH2_Human1.00467027
61PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96954684
62RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.95964692
63MYB_21317192_ChIP-Seq_ERMYB_Mouse0.94296400
64DROSHA_22980978_ChIP-Seq_HELA_Human0.93366293
65GATA1_19941827_ChIP-Seq_MEL_Mouse0.93158705
66* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90304523
67RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90227097
68PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89786525
69GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88964053
70ER_23166858_ChIP-Seq_MCF-7_Human0.88764449
71GBX2_23144817_ChIP-Seq_PC3_Human0.88075826
72BCAT_22108803_ChIP-Seq_LS180_Human0.86534343
73EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.85581285
74GATA3_26560356_Chip-Seq_TH1_Human0.85250042
75STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.85164300
76PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.85076378
77GATA1_19941826_ChIP-Seq_K562_Human0.85048928
78VDR_21846776_ChIP-Seq_THP-1_Human0.84700445
79BRD4_27068464_Chip-Seq_AML-cells_Mouse0.83805013
80RXR_22108803_ChIP-Seq_LS180_Human0.83713647
81CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83094151
82CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82983203
83HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.81331315
84GATA3_21878914_ChIP-Seq_MCF-7_Human0.81149273
85NANOG_20526341_ChIP-Seq_ESCs_Human0.80244458
86TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79537865
87* TDRD3_21172665_ChIP-Seq_MCF-7_Human0.79489048
88ELF1_17652178_ChIP-ChIP_JURKAT_Human0.78304899
89CIITA_25753668_ChIP-Seq_RAJI_Human0.78141538
90GATA2_19941826_ChIP-Seq_K562_Human0.77575657
91CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.76793469
92FLI1_27457419_Chip-Seq_LIVER_Mouse0.75699697
93Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.75084904
94P300_27268052_Chip-Seq_Bcells_Human0.73589386
95CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.73043259
96STAT1_20625510_ChIP-Seq_HELA_Human0.72941749
97BCL6_27268052_Chip-Seq_Bcells_Human0.72898706
98* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.71261914
99GATA2_22383799_ChIP-Seq_G1ME_Mouse0.70371691
100GATA2_21666600_ChIP-Seq_HMVEC_Human0.69448799

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.53798354
2MP0005671_abnormal_response_to4.38076009
3MP0001835_abnormal_antigen_presentation3.94600599
4MP0000685_abnormal_immune_system3.43699486
5MP0001800_abnormal_humoral_immune3.37181897
6MP0003436_decreased_susceptibility_to3.21158323
7MP0001790_abnormal_immune_system2.96457566
8MP0005387_immune_system_phenotype2.96457566
9MP0005000_abnormal_immune_tolerance2.89139256
10MP0003763_abnormal_thymus_physiology2.84733633
11MP0009785_altered_susceptibility_to2.74132486
12MP0002723_abnormal_immune_serum2.66471655
13MP0005025_abnormal_response_to2.56917472
14MP0002452_abnormal_antigen_presenting2.56539155
15MP0002420_abnormal_adaptive_immunity2.52641903
16MP0001819_abnormal_immune_cell2.50274668
17MP0002148_abnormal_hypersensitivity_rea2.38329897
18MP0002419_abnormal_innate_immunity2.34882842
19MP0003866_abnormal_defecation1.99451135
20MP0002138_abnormal_hepatobiliary_system1.97694915
21MP0010155_abnormal_intestine_physiology1.96041458
22MP0000716_abnormal_immune_system1.93833447
23MP0006082_CNS_inflammation1.90104137
24MP0002398_abnormal_bone_marrow1.89491544
25MP0002405_respiratory_system_inflammati1.85930846
26MP0005464_abnormal_platelet_physiology1.81704196
27MP0001873_stomach_inflammation1.76125562
28MP0009333_abnormal_splenocyte_physiolog1.75015342
29MP0000689_abnormal_spleen_morphology1.69675884
30MP0001533_abnormal_skeleton_physiology1.67096888
31MP0001845_abnormal_inflammatory_respons1.64954557
32MP0004130_abnormal_muscle_cell1.59102132
33MP0003303_peritoneal_inflammation1.59030671
34MP0000569_abnormal_digit_pigmentation1.53127050
35MP0002722_abnormal_immune_system1.52242122
36MP0000465_gastrointestinal_hemorrhage1.48359517
37MP0004947_skin_inflammation1.48054512
38MP0000703_abnormal_thymus_morphology1.45887906
39MP0009764_decreased_sensitivity_to1.44612610
40MP0001986_abnormal_taste_sensitivity1.44274346
41MP0002429_abnormal_blood_cell1.42792486
42MP0002166_altered_tumor_susceptibility1.42234091
43MP0005310_abnormal_salivary_gland1.41937580
44MP0002277_abnormal_respiratory_mucosa1.41024689
45MP0004381_abnormal_hair_follicle1.38104665
46MP0008469_abnormal_protein_level1.23014831
47MP0001663_abnormal_digestive_system1.20742592
48MP0005075_abnormal_melanosome_morpholog1.13016735
49MP0008877_abnormal_DNA_methylation1.05068837
50MP0001765_abnormal_ion_homeostasis1.04641936
51MP0002132_abnormal_respiratory_system1.03444664
52MP0005360_urolithiasis1.03365006
53MP0002933_joint_inflammation1.01937440
54MP0008872_abnormal_physiological_respon1.01210947
55MP0003183_abnormal_peptide_metabolism0.99916676
56MP0002876_abnormal_thyroid_physiology0.98370182
57MP0003646_muscle_fatigue0.97717199
58MP0004885_abnormal_endolymph0.94802008
59MP0009765_abnormal_xenobiotic_induced0.94520725
60MP0004883_abnormal_blood_vessel0.92935327
61MP0004142_abnormal_muscle_tone0.90843485
62MP0003300_gastrointestinal_ulcer0.89252001
63MP0002998_abnormal_bone_remodeling0.87300966
64MP0005174_abnormal_tail_pigmentation0.86915152
65MP0002006_tumorigenesis0.86114996
66MP0002396_abnormal_hematopoietic_system0.85342445
67MP0005389_reproductive_system_phenotype0.85341318
68MP0003045_fibrosis0.83660370
69MP0001485_abnormal_pinna_reflex0.83496687
70MP0003638_abnormal_response/metabolism_0.78231662
71MP0001440_abnormal_grooming_behavior0.77158685
72MP0003252_abnormal_bile_duct0.76483527
73MP0001851_eye_inflammation0.75386692
74MP0002693_abnormal_pancreas_physiology0.73280545
75MP0009763_increased_sensitivity_to0.72993887
76MP0005646_abnormal_pituitary_gland0.72792631
77MP0000015_abnormal_ear_pigmentation0.71925862
78MP0001919_abnormal_reproductive_system0.70109109
79MP0002136_abnormal_kidney_physiology0.69868427
80MP0001348_abnormal_lacrimal_gland0.68868237
81MP0002653_abnormal_ependyma_morphology0.68758252
82MP0003828_pulmonary_edema0.67766984
83MP0002928_abnormal_bile_duct0.66729104
84MP0000230_abnormal_systemic_arterial0.66282187
85MP0005164_abnormal_response_to0.65484826
86MP0005390_skeleton_phenotype0.63331678
87MP0005085_abnormal_gallbladder_physiolo0.62764663
88MP0001968_abnormal_touch/_nociception0.62508241
89MP0009278_abnormal_bone_marrow0.61710455
90MP0003172_abnormal_lysosome_physiology0.60491277
91MP0005166_decreased_susceptibility_to0.60103923
92MP0005381_digestive/alimentary_phenotyp0.59793526
93MP0003879_abnormal_hair_cell0.57746960
94MP0000470_abnormal_stomach_morphology0.57649297
95MP0004510_myositis0.57490618
96MP0010329_abnormal_lipoprotein_level0.57398395
97MP0003011_delayed_dark_adaptation0.54717119
98MP0000249_abnormal_blood_vessel0.54581990
99MP0009642_abnormal_blood_homeostasis0.53839104
100MP0005084_abnormal_gallbladder_morpholo0.53200677

Predicted human phenotypes

RankGene SetZ-score
1Abnormal delayed hypersensitivity skin test (HP:0002963)4.38090964
2Elevated erythrocyte sedimentation rate (HP:0003565)4.18682286
3Myositis (HP:0100614)4.17605793
4Abnormality of T cell number (HP:0011839)4.14356051
5Eczematoid dermatitis (HP:0000976)4.01426391
6T lymphocytopenia (HP:0005403)4.01283556
7Stomatitis (HP:0010280)4.00772317
8Panhypogammaglobulinemia (HP:0003139)3.86209261
9Optic neuritis (HP:0100653)3.84545328
10Retrobulbar optic neuritis (HP:0100654)3.84545328
11Orchitis (HP:0100796)3.75904977
12Recurrent fungal infections (HP:0002841)3.74819162
13Recurrent bacterial skin infections (HP:0005406)3.48281973
14Encephalitis (HP:0002383)3.47251429
15Chronic mucocutaneous candidiasis (HP:0002728)3.45001913
16Recurrent cutaneous fungal infections (HP:0011370)3.45001913
17Abnormality of T cells (HP:0002843)3.40935284
18IgG deficiency (HP:0004315)3.35327915
19Mediastinal lymphadenopathy (HP:0100721)3.34851395
20Recurrent abscess formation (HP:0002722)3.32022988
21Meningitis (HP:0001287)3.27778678
22Pustule (HP:0200039)3.23700535
23Pulmonary infiltrates (HP:0002113)3.08672844
24Vasculitis (HP:0002633)3.06670626
25Gastrointestinal infarctions (HP:0005244)3.04516263
26Leukocytosis (HP:0001974)3.00366227
27Eosinophilia (HP:0001880)2.90998337
28Chronic otitis media (HP:0000389)2.87967802
29Hemiplegia (HP:0002301)2.85594930
30Recurrent skin infections (HP:0001581)2.84555063
31Prolonged bleeding time (HP:0003010)2.81459937
32Recurrent bronchitis (HP:0002837)2.79093866
33Severe combined immunodeficiency (HP:0004430)2.78217384
34Abnormality of eosinophils (HP:0001879)2.78142448
35Abnormality of T cell physiology (HP:0011840)2.77996775
36Stomach cancer (HP:0012126)2.75095239
37Abnormality of macrophages (HP:0004311)2.74618024
38Keratoconjunctivitis (HP:0001096)2.73990522
39Agammaglobulinemia (HP:0004432)2.72787442
40Keratoconjunctivitis sicca (HP:0001097)2.71465225
41Granulocytopenia (HP:0001913)2.69043677
42Autoimmune hemolytic anemia (HP:0001890)2.68057783
43Spontaneous hematomas (HP:0007420)2.66212625
44Increased IgM level (HP:0003496)2.65741793
45Hypochromic anemia (HP:0001931)2.60889618
46Recurrent gram-negative bacterial infections (HP:0005420)2.58938574
47Recurrent viral infections (HP:0004429)2.56610764
48Hemoptysis (HP:0002105)2.55484572
49Abnormality of B cell number (HP:0010975)2.52141053
50Congenital stationary night blindness (HP:0007642)2.49281490
51Genetic anticipation (HP:0003743)2.48653101
52Decreased circulating renin level (HP:0003351)2.46247069
53Verrucae (HP:0200043)2.36547308
54Papilloma (HP:0012740)2.36547308
55Obstructive lung disease (HP:0006536)2.36036679
56Chronic obstructive pulmonary disease (HP:0006510)2.36036679
57Conjunctival hamartoma (HP:0100780)2.35135904
58Chronic sinusitis (HP:0011109)2.27194866
59Clumsiness (HP:0002312)2.26765628
60Thyroiditis (HP:0100646)2.24467646
61Inflammation of the large intestine (HP:0002037)2.23824440
62Hypochromic microcytic anemia (HP:0004840)2.22314605
63Chest pain (HP:0100749)2.19108364
64Abolished electroretinogram (ERG) (HP:0000550)2.18514928
65Persistence of primary teeth (HP:0006335)2.14865243
66Epistaxis (HP:0000421)2.12220999
67Autoimmune thrombocytopenia (HP:0001973)2.10787473
68Abnormality of the prostate (HP:0008775)2.08447094
69Recurrent sinusitis (HP:0011108)2.07615472
70Congenital sensorineural hearing impairment (HP:0008527)2.06611732
71Gastrointestinal inflammation (HP:0004386)2.06485057
72Absent rod-and cone-mediated responses on ERG (HP:0007688)2.04499757
73Progressive cerebellar ataxia (HP:0002073)2.03765416
74Chronic diarrhea (HP:0002028)2.02825302
75Prostate neoplasm (HP:0100787)2.02439511
76Abnormality of the pleura (HP:0002103)2.01999108
77Pulmonary embolism (HP:0002204)2.01111814
78Urticaria (HP:0001025)1.98491040
79Gingival bleeding (HP:0000225)1.97371072
80Alveolar cell carcinoma (HP:0006519)1.95382373
81Abnormality of cells of the lymphoid lineage (HP:0012140)1.94662874
82Lymphopenia (HP:0001888)1.94639044
83Asplenia (HP:0001746)1.90478714
84Combined immunodeficiency (HP:0005387)1.90457894
85Anorexia (HP:0002039)1.89873629
86B lymphocytopenia (HP:0010976)1.89539079
87Petechiae (HP:0000967)1.88082256
88Arterial thrombosis (HP:0004420)1.86648962
89Increased IgE level (HP:0003212)1.85967247
90Bone cyst (HP:0012062)1.85676991
91Decreased electroretinogram (ERG) amplitude (HP:0000654)1.85654891
92Neoplasm of the tracheobronchial system (HP:0100552)1.83042521
93Abnormality of binocular vision (HP:0011514)1.83041345
94Diplopia (HP:0000651)1.83041345
95Abnormal rod and cone electroretinograms (HP:0008323)1.82851031
96Colitis (HP:0002583)1.80457017
97Ventricular fibrillation (HP:0001663)1.79687858
98Microcytic anemia (HP:0001935)1.78630478
99Gingivitis (HP:0000230)1.77523831
100Gangrene (HP:0100758)1.77298513

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.06826895
2TAOK34.03337438
3BLK3.51548030
4TXK3.36422484
5RIPK43.25016429
6FRK2.61375292
7GRK62.31877354
8SYK2.15673992
9CSK2.08907112
10ADRBK22.08844735
11TLK12.04158421
12FES1.99857078
13TYK21.98403056
14ZAP701.91165597
15IKBKE1.89614677
16BTK1.80733961
17ACVR1B1.78451155
18KIT1.76862344
19TEC1.72289917
20TNK21.70586856
21ITK1.70249915
22JAK31.69156593
23IRAK41.63049479
24ERN11.57009820
25LYN1.51702684
26GRK11.48833233
27JAK11.47972911
28IKBKB1.41491102
29LCK1.41107711
30HCK1.40254261
31SIK21.40212923
32GRK71.30983984
33CSF1R1.28172149
34MAP2K31.20674514
35MAP3K141.14878711
36SGK21.09652743
37CAMKK21.07094592
38TBK11.06954382
39PRKCQ1.02032293
40NLK0.99950469
41MARK30.92974222
42PTK2B0.91086747
43MAP3K130.89247138
44PRKD20.89225838
45HIPK20.88760644
46MAP3K110.88256287
47BMPR1B0.87076120
48GRK50.85597986
49JAK20.85038394
50NEK90.83658739
51ADRBK10.82460431
52SGK30.75522412
53FGR0.75408482
54PIM10.74192137
55EPHB10.73451289
56FGFR30.71633890
57PIK3CA0.70968499
58MAPK120.69322507
59MAPK70.68997304
60SGK4940.68611698
61SGK2230.68611698
62IRAK10.67759441
63MAP2K60.65412977
64PDK10.65045610
65RPS6KA60.64824069
66CAMKK10.64201816
67EPHA30.60936014
68BMPR20.60717636
69NUAK10.60345343
70MATK0.60182876
71STK100.58055217
72MAPK110.57280224
73MAP4K20.55884667
74MAP3K70.55557689
75CDK190.54105987
76PIK3CG0.53374786
77FYN0.53328513
78TGFBR20.52524561
79MAP2K20.51424238
80PINK10.51175896
81MAPK130.50648948
82TAOK10.50497432
83CDC42BPA0.48645328
84MAP3K30.47973257
85STK110.47818404
86TESK20.47584828
87DAPK20.46808005
88PRKCH0.45491228
89MARK20.42394300
90RPS6KL10.40383517
91RPS6KC10.40383517
92CHUK0.37623975
93MAP3K10.37270464
94MAPKAPK30.37079868
95MELK0.36981305
96FGFR40.36748883
97TRPM70.36404431
98OXSR10.35508990
99PRKD10.34790875
100ERBB20.34752028

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.63607323
2Graft-versus-host disease_Homo sapiens_hsa053323.42148623
3Allograft rejection_Homo sapiens_hsa053303.36527599
4Autoimmune thyroid disease_Homo sapiens_hsa053203.21072795
5Intestinal immune network for IgA production_Homo sapiens_hsa046723.20415321
6Asthma_Homo sapiens_hsa053102.60330251
7Staphylococcus aureus infection_Homo sapiens_hsa051502.55011313
8Type I diabetes mellitus_Homo sapiens_hsa049402.54156547
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.41571312
10Leishmaniasis_Homo sapiens_hsa051402.14151828
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.06747344
12Antigen processing and presentation_Homo sapiens_hsa046122.06721538
13Hematopoietic cell lineage_Homo sapiens_hsa046401.89359143
14T cell receptor signaling pathway_Homo sapiens_hsa046601.83456927
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.77818621
16Osteoclast differentiation_Homo sapiens_hsa043801.77133496
17B cell receptor signaling pathway_Homo sapiens_hsa046621.67638686
18Measles_Homo sapiens_hsa051621.49768198
19Viral myocarditis_Homo sapiens_hsa054161.45223903
20Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.42036603
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.39836745
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.38306992
23NOD-like receptor signaling pathway_Homo sapiens_hsa046211.37087145
24Tuberculosis_Homo sapiens_hsa051521.33016485
25Jak-STAT signaling pathway_Homo sapiens_hsa046301.31065158
26Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.30691806
27Chemokine signaling pathway_Homo sapiens_hsa040621.24935912
28Linoleic acid metabolism_Homo sapiens_hsa005911.24806160
29Herpes simplex infection_Homo sapiens_hsa051681.21808285
30Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.21624492
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.21359893
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.19754117
33Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.17032003
34Rheumatoid arthritis_Homo sapiens_hsa053231.10763206
35Toxoplasmosis_Homo sapiens_hsa051451.09564393
36Dorso-ventral axis formation_Homo sapiens_hsa043201.09128532
37Influenza A_Homo sapiens_hsa051641.08227349
38Malaria_Homo sapiens_hsa051441.04440267
39Platelet activation_Homo sapiens_hsa046111.02136294
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.99083500
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.96146708
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.95280606
43African trypanosomiasis_Homo sapiens_hsa051430.94541043
44Systemic lupus erythematosus_Homo sapiens_hsa053220.91538866
45Caffeine metabolism_Homo sapiens_hsa002320.89845612
46TNF signaling pathway_Homo sapiens_hsa046680.89780463
47Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78952163
48Morphine addiction_Homo sapiens_hsa050320.74590861
49Maturity onset diabetes of the young_Homo sapiens_hsa049500.71064191
50Hepatitis C_Homo sapiens_hsa051600.70769739
51Arachidonic acid metabolism_Homo sapiens_hsa005900.70494795
52Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.70100208
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66517605
54Glycerolipid metabolism_Homo sapiens_hsa005610.66062752
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64617907
56Ether lipid metabolism_Homo sapiens_hsa005650.64557537
57Renin secretion_Homo sapiens_hsa049240.59585706
58ABC transporters_Homo sapiens_hsa020100.58354981
59Cholinergic synapse_Homo sapiens_hsa047250.57648016
60Nitrogen metabolism_Homo sapiens_hsa009100.57462479
61Phototransduction_Homo sapiens_hsa047440.56885866
62Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56330857
63Phagosome_Homo sapiens_hsa041450.56147506
64Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55334950
65Acute myeloid leukemia_Homo sapiens_hsa052210.55265331
66MAPK signaling pathway_Homo sapiens_hsa040100.53139077
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51926433
68Chemical carcinogenesis_Homo sapiens_hsa052040.51146568
69Pertussis_Homo sapiens_hsa051330.51042460
70Prolactin signaling pathway_Homo sapiens_hsa049170.50958026
71Gastric acid secretion_Homo sapiens_hsa049710.49759652
72Insulin resistance_Homo sapiens_hsa049310.48508701
73Vitamin digestion and absorption_Homo sapiens_hsa049770.47935390
74Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.47505751
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46761752
76Hepatitis B_Homo sapiens_hsa051610.46165903
77Olfactory transduction_Homo sapiens_hsa047400.46116738
78Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45607126
79Renin-angiotensin system_Homo sapiens_hsa046140.44602702
80Retinol metabolism_Homo sapiens_hsa008300.44529246
81Glycerophospholipid metabolism_Homo sapiens_hsa005640.43733812
82Serotonergic synapse_Homo sapiens_hsa047260.43082136
83Type II diabetes mellitus_Homo sapiens_hsa049300.40160518
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.40112959
85Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.39431737
86Taste transduction_Homo sapiens_hsa047420.39410144
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38401720
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.37751484
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.37522868
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.36492442
91FoxO signaling pathway_Homo sapiens_hsa040680.36178632
92Sulfur metabolism_Homo sapiens_hsa009200.35751006
93Apoptosis_Homo sapiens_hsa042100.35248581
94Oxytocin signaling pathway_Homo sapiens_hsa049210.34976189
95Calcium signaling pathway_Homo sapiens_hsa040200.34777589
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.33104887
97Legionellosis_Homo sapiens_hsa051340.32738764
98Ovarian steroidogenesis_Homo sapiens_hsa049130.32655164
99Circadian entrainment_Homo sapiens_hsa047130.31772218
100Ras signaling pathway_Homo sapiens_hsa040140.31567515

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