BTN3A3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The butyrophilin (BTN) genes are a group of major histocompatibility complex (MHC)-associated genes that encode type I membrane proteins with 2 extracellular immunoglobulin (Ig) domains and an intracellular B30.2 (PRYSPRY) domain. Three subfamilies of human BTN genes are located in the MHC class I region: the single-copy BTN1A1 gene (MIM 601610) and the BTN2 (e.g., BTN2A1; MIM 613590) and BTN3 (e.g., BNT3A3) genes, which have undergone tandem duplication, resulting in 3 copies of each (summary by Smith et al., 2010 [PubMed 20208008]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)6.70984274
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.70984274
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.45476917
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.34471927
5positive regulation of gamma-delta T cell activation (GO:0046645)6.22878952
6antigen processing and presentation of endogenous antigen (GO:0019883)6.07447176
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.91349218
8regulation of B cell receptor signaling pathway (GO:0050855)5.06863355
9positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.85838105
10negative T cell selection (GO:0043383)4.78573835
11negative thymic T cell selection (GO:0045060)4.74203470
12regulation of gamma-delta T cell activation (GO:0046643)4.59318604
13regulation of gamma-delta T cell differentiation (GO:0045586)4.42621489
14positive thymic T cell selection (GO:0045059)4.39846132
15leukocyte aggregation (GO:0070486)4.37450715
16positive regulation by symbiont of host defense response (GO:0052509)4.36154247
17modulation by symbiont of host defense response (GO:0052031)4.36154247
18modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.36154247
19modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.36154247
20positive regulation by organism of defense response of other organism involved in symbiotic interact4.36154247
21modulation by symbiont of host immune response (GO:0052553)4.36154247
22detection of other organism (GO:0098543)4.27474435
23detection of bacterium (GO:0016045)4.19298798
24response to interleukin-15 (GO:0070672)4.16778137
25cellular response to type I interferon (GO:0071357)4.14872247
26type I interferon signaling pathway (GO:0060337)4.14872247
27response to type I interferon (GO:0034340)4.13121659
28positive T cell selection (GO:0043368)4.09004143
29negative regulation of lymphocyte mediated immunity (GO:0002707)4.07396656
30T cell migration (GO:0072678)3.97303707
31regulation of T cell tolerance induction (GO:0002664)3.94341033
32negative regulation of T cell mediated immunity (GO:0002710)3.89696076
33T cell selection (GO:0045058)3.88987467
34thymic T cell selection (GO:0045061)3.86203140
35cellular response to interleukin-15 (GO:0071350)3.86046215
36antigen processing and presentation via MHC class Ib (GO:0002475)3.70235508
37macrophage activation involved in immune response (GO:0002281)3.70222316
38activated T cell proliferation (GO:0050798)3.67639290
39negative regulation of interleukin-12 production (GO:0032695)3.67168900
40negative regulation of leukocyte mediated immunity (GO:0002704)3.65064321
41regulation of tolerance induction (GO:0002643)3.64966072
42B cell receptor signaling pathway (GO:0050853)3.62970331
43neutrophil activation involved in immune response (GO:0002283)3.60240115
44positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.57932278
45detection of external biotic stimulus (GO:0098581)3.55112329
46immunoglobulin mediated immune response (GO:0016064)3.54978890
47regulation of alpha-beta T cell proliferation (GO:0046640)3.54843283
48regulation of regulatory T cell differentiation (GO:0045589)3.53078630
49interferon-gamma-mediated signaling pathway (GO:0060333)3.53033729
50regulation of interferon-beta biosynthetic process (GO:0045357)3.48318029
51regulation of B cell differentiation (GO:0045577)3.42512006
52positive regulation of tolerance induction (GO:0002645)3.39914633
53regulation of T cell mediated cytotoxicity (GO:0001914)3.39149129
54cellular extravasation (GO:0045123)3.36096191
55positive regulation of B cell differentiation (GO:0045579)3.36011592
56regulation of natural killer cell mediated immunity (GO:0002715)3.30387751
57regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.30387751
58regulation of dendritic cell antigen processing and presentation (GO:0002604)3.25983218
59positive regulation of T cell mediated cytotoxicity (GO:0001916)3.20320414
60regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.17177051
61positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.16058918
62detection of biotic stimulus (GO:0009595)3.14194145
63detection of molecule of bacterial origin (GO:0032490)3.12834009
64tolerance induction (GO:0002507)3.10211820
65response to peptidoglycan (GO:0032494)3.09957145
66negative regulation of innate immune response (GO:0045824)3.09837395
67response to host immune response (GO:0052572)3.09486247
68response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.09486247
69antigen receptor-mediated signaling pathway (GO:0050851)3.01721140
70positive regulation of granulocyte differentiation (GO:0030854)3.00881322
71regulation of antigen processing and presentation (GO:0002577)2.99075205
72microglial cell activation (GO:0001774)2.97724387
73response to host (GO:0075136)2.97133976
74response to host defenses (GO:0052200)2.97133976
75response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.97133976
76regulation of leukocyte mediated cytotoxicity (GO:0001910)2.96636552
77interferon-gamma production (GO:0032609)2.95684073
78negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.95024798
79positive regulation of alpha-beta T cell proliferation (GO:0046641)2.94899960
80respiratory burst (GO:0045730)2.93412207
81defense response to protozoan (GO:0042832)2.93008072
82T cell receptor signaling pathway (GO:0050852)2.92980051
83myeloid cell activation involved in immune response (GO:0002275)2.91883693
84response to muramyl dipeptide (GO:0032495)2.91419092
85regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.90676201
86NIK/NF-kappaB signaling (GO:0038061)2.88822046
87negative regulation of erythrocyte differentiation (GO:0045647)2.88819628
88neutrophil activation (GO:0042119)2.87788159
89positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.85721061
90B cell mediated immunity (GO:0019724)2.85241137
91negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.84568084
92positive regulation of antigen processing and presentation (GO:0002579)2.82102932
93interferon-gamma secretion (GO:0072643)2.80486075
94positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.80225117
95regulation of interleukin-2 biosynthetic process (GO:0045076)2.78406847
96germinal center formation (GO:0002467)2.75899794
97negative regulation of type 2 immune response (GO:0002829)2.75189175
98positive regulation of interferon-alpha production (GO:0032727)2.75121520
99dendritic cell chemotaxis (GO:0002407)2.74756431
100regulation of cell killing (GO:0031341)2.73300963

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.56060584
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.07541710
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.70888227
4* IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.24286707
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.89807633
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.79794056
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.28762158
8RUNX_20019798_ChIP-Seq_JUKART_Human3.16875485
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.16581949
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.99238851
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.93636032
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.87827025
13MYB_26560356_Chip-Seq_TH2_Human2.70097290
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.59949901
15FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.54738547
16STAT4_19710469_ChIP-ChIP_TH1__Mouse2.45273921
17MAF_26560356_Chip-Seq_TH1_Human2.43690961
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.40542014
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.38263315
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.38098524
21MYB_26560356_Chip-Seq_TH1_Human2.26894337
22SPI1_23547873_ChIP-Seq_NB4_Human2.21490097
23UTX_26944678_Chip-Seq_JUKART_Human2.14332929
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.13493166
25E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.12119526
26VDR_24763502_ChIP-Seq_THP-1_Human2.11491667
27VDR_21846776_ChIP-Seq_THP-1_Human2.09419132
28SPI1_23127762_ChIP-Seq_K562_Human2.06692093
29MYC_22102868_ChIP-Seq_BL_Human2.04774908
30RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.00116729
31SCL_19346495_ChIP-Seq_HPC-7_Human1.97211649
32RUNX1_22412390_ChIP-Seq_EML_Mouse1.95101760
33VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.94535575
34BRD4_27068464_Chip-Seq_AML-cells_Mouse1.91059442
35NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.90498806
36* GATA3_27048872_Chip-Seq_THYMUS_Human1.85871044
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.85097317
38MAF_26560356_Chip-Seq_TH2_Human1.77530429
39TCF7_22412390_ChIP-Seq_EML_Mouse1.72510761
40KDM2B_26808549_Chip-Seq_SUP-B15_Human1.68392819
41EGR1_19374776_ChIP-ChIP_THP-1_Human1.64821693
42Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.63036613
43MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.55140558
44VDR_24787735_ChIP-Seq_THP-1_Human1.52900999
45KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.50492196
46KDM2B_26808549_Chip-Seq_DND41_Human1.49302528
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.44109967
48KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.43819871
49GATA1_22025678_ChIP-Seq_K562_Human1.43551145
50* GATA3_26560356_Chip-Seq_TH2_Human1.40236795
51ELF1_17652178_ChIP-ChIP_JURKAT_Human1.37747500
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.37698424
53GATA1_19941827_ChIP-Seq_MEL_Mouse1.37541433
54* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.33658210
55* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33061623
56LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.32556032
57GATA2_22383799_ChIP-Seq_G1ME_Mouse1.29684349
58TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.28424786
59ELK3_25401928_ChIP-Seq_HUVEC_Human1.25553952
60GATA2_21666600_ChIP-Seq_HMVEC_Human1.24152607
61PU_27001747_Chip-Seq_BMDM_Mouse1.23135109
62SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.20763101
63GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.17603811
64FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17394816
65SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.14303694
66ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.10921069
67PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10854429
68STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.09996602
69CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09518134
70GATA1_22383799_ChIP-Seq_G1ME_Mouse1.09181885
71GATA1_19941826_ChIP-Seq_K562_Human1.08437163
72* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07935299
73PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06879479
74KDM2B_26808549_Chip-Seq_JURKAT_Human1.05804499
75CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05308750
76RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.04283419
77LXR_22292898_ChIP-Seq_THP-1_Human1.04198016
78* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01364300
79GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00151818
80PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98418760
81SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97954677
82PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96393013
83GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95578140
84SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93721145
85VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.92713224
86NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.92672177
87TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92265755
88* BCL6_27268052_Chip-Seq_Bcells_Human0.87770212
89GATA2_19941826_ChIP-Seq_K562_Human0.86570981
90TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84243153
91CIITA_25753668_ChIP-Seq_RAJI_Human0.83445342
92PPARA_22158963_ChIP-Seq_LIVER_Mouse0.83159925
93STAT6_21828071_ChIP-Seq_BEAS2B_Human0.79177969
94* BCOR_27268052_Chip-Seq_Bcells_Human0.77489615
95CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.76429721
96CTCF_27219007_Chip-Seq_ERYTHROID_Human0.73803129
97SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.73428061
98NCOR1_26117541_ChIP-Seq_K562_Human0.72387125
99BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.70027880
100RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69743056

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.18054689
2MP0001835_abnormal_antigen_presentation4.10601697
3MP0003436_decreased_susceptibility_to3.67205654
4MP0005671_abnormal_response_to3.66821372
5MP0003763_abnormal_thymus_physiology3.32402455
6MP0001800_abnormal_humoral_immune3.14304671
7MP0000685_abnormal_immune_system3.05330951
8MP0003303_peritoneal_inflammation3.02156183
9MP0005387_immune_system_phenotype2.95532308
10MP0001790_abnormal_immune_system2.95532308
11MP0005000_abnormal_immune_tolerance2.87152559
12MP0009785_altered_susceptibility_to2.86245349
13MP0005025_abnormal_response_to2.78042914
14MP0002419_abnormal_innate_immunity2.67443214
15MP0002723_abnormal_immune_serum2.65455356
16MP0006082_CNS_inflammation2.60231572
17MP0003300_gastrointestinal_ulcer2.59259295
18MP0002452_abnormal_antigen_presenting2.56144527
19MP0002420_abnormal_adaptive_immunity2.54051168
20MP0001819_abnormal_immune_cell2.51648086
21MP0010155_abnormal_intestine_physiology2.22342584
22MP0002148_abnormal_hypersensitivity_rea2.20116525
23MP0009333_abnormal_splenocyte_physiolog2.12084572
24MP0002398_abnormal_bone_marrow2.00964398
25MP0002405_respiratory_system_inflammati2.00561972
26MP0000716_abnormal_immune_system1.96521181
27MP0002166_altered_tumor_susceptibility1.96308484
28MP0003866_abnormal_defecation1.91711839
29MP0004947_skin_inflammation1.91463229
30MP0001533_abnormal_skeleton_physiology1.89884881
31MP0003191_abnormal_cellular_cholesterol1.89141738
32MP0005464_abnormal_platelet_physiology1.81581442
33MP0001845_abnormal_inflammatory_respons1.78647693
34MP0000689_abnormal_spleen_morphology1.64441939
35MP0000703_abnormal_thymus_morphology1.63832837
36MP0002722_abnormal_immune_system1.62260699
37MP0000465_gastrointestinal_hemorrhage1.57309258
38MP0001873_stomach_inflammation1.56325766
39MP0002429_abnormal_blood_cell1.53576852
40MP0008260_abnormal_autophagy1.50804376
41MP0008469_abnormal_protein_level1.45442966
42MP0002396_abnormal_hematopoietic_system1.44584387
43MP0005451_abnormal_body_composition1.42490643
44MP0000858_altered_metastatic_potential1.36975837
45MP0004381_abnormal_hair_follicle1.34469796
46MP0003172_abnormal_lysosome_physiology1.33578389
47MP0004883_abnormal_blood_vessel1.33501147
48MP0001851_eye_inflammation1.29626087
49MP0002006_tumorigenesis1.28141982
50MP0003828_pulmonary_edema1.27433515
51MP0005310_abnormal_salivary_gland1.26577420
52MP0002998_abnormal_bone_remodeling1.26457510
53MP0003183_abnormal_peptide_metabolism1.26088607
54MP0002933_joint_inflammation1.21180607
55MP0002132_abnormal_respiratory_system1.19875725
56MP0009764_decreased_sensitivity_to1.18956786
57MP0005166_decreased_susceptibility_to1.14377888
58MP0001853_heart_inflammation1.11812295
59MP0003448_altered_tumor_morphology1.08786854
60MP0003045_fibrosis1.07450787
61MP0009278_abnormal_bone_marrow1.05356384
62MP0005164_abnormal_response_to1.04833026
63MP0002138_abnormal_hepatobiliary_system1.04114683
64MP0003690_abnormal_glial_cell1.01996270
65MP0005397_hematopoietic_system_phenotyp1.00953842
66MP0001545_abnormal_hematopoietic_system1.00953842
67MP0002009_preneoplasia0.99978194
68MP0003075_altered_response_to0.94786803
69MP0000604_amyloidosis0.93225248
70MP0009763_increased_sensitivity_to0.92328691
71MP0001663_abnormal_digestive_system0.90235061
72MP0003091_abnormal_cell_migration0.88695512
73MP0005058_abnormal_lysosome_morphology0.88435819
74MP0002277_abnormal_respiratory_mucosa0.85707792
75MP0000249_abnormal_blood_vessel0.85488150
76MP0004510_myositis0.84290833
77MP0005075_abnormal_melanosome_morpholog0.84244641
78MP0005390_skeleton_phenotype0.78096045
79MP0001986_abnormal_taste_sensitivity0.77371236
80MP0001958_emphysema0.76830986
81MP0005360_urolithiasis0.75737273
82MP0008004_abnormal_stomach_pH0.75559113
83MP0004808_abnormal_hematopoietic_stem0.73878148
84MP0000343_altered_response_to0.73029211
85MP0004130_abnormal_muscle_cell0.71268144
86MP0000490_abnormal_crypts_of0.71192979
87MP0003795_abnormal_bone_structure0.67438401
88MP0000015_abnormal_ear_pigmentation0.66030584
89MP0009840_abnormal_foam_cell0.63877409
90MP0003279_aneurysm0.62236366
91MP0009765_abnormal_xenobiotic_induced0.60462633
92MP0003252_abnormal_bile_duct0.59711474
93MP0008874_decreased_physiological_sensi0.57231366
94MP0003656_abnormal_erythrocyte_physiolo0.56832437
95MP0002019_abnormal_tumor_incidence0.54938941
96MP0000609_abnormal_liver_physiology0.54797564
97MP0002133_abnormal_respiratory_system0.53797097
98MP0005388_respiratory_system_phenotype0.53797097
99MP0009115_abnormal_fat_cell0.52397733
100MP0002136_abnormal_kidney_physiology0.51533263

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.18170296
2Recurrent bacterial skin infections (HP:0005406)4.94006822
3Myositis (HP:0100614)4.87208354
4Recurrent abscess formation (HP:0002722)4.79954566
5Elevated erythrocyte sedimentation rate (HP:0003565)4.69824838
6T lymphocytopenia (HP:0005403)4.60978754
7Abnormality of T cell number (HP:0011839)4.50764723
8Orchitis (HP:0100796)4.45153137
9Abnormal delayed hypersensitivity skin test (HP:0002963)4.39522188
10Optic neuritis (HP:0100653)4.30426013
11Retrobulbar optic neuritis (HP:0100654)4.30426013
12Abnormality of macrophages (HP:0004311)4.26659621
13Recurrent fungal infections (HP:0002841)4.19515998
14Gastrointestinal infarctions (HP:0005244)4.13220341
15Meningitis (HP:0001287)3.93307731
16Recurrent gram-negative bacterial infections (HP:0005420)3.88432739
17Stomatitis (HP:0010280)3.87497087
18Chronic mucocutaneous candidiasis (HP:0002728)3.87320451
19Recurrent cutaneous fungal infections (HP:0011370)3.87320451
20Vasculitis (HP:0002633)3.72982864
21Recurrent skin infections (HP:0001581)3.68570108
22Mediastinal lymphadenopathy (HP:0100721)3.60716104
23Encephalitis (HP:0002383)3.58089601
24Panhypogammaglobulinemia (HP:0003139)3.52384957
25Abnormality of T cells (HP:0002843)3.51071374
26Spontaneous hematomas (HP:0007420)3.47904080
27Recurrent viral infections (HP:0004429)3.42846888
28Obstructive lung disease (HP:0006536)3.25502483
29Chronic obstructive pulmonary disease (HP:0006510)3.25502483
30Pustule (HP:0200039)3.25191425
31Pulmonary infiltrates (HP:0002113)3.24168419
32Gingivitis (HP:0000230)3.19868141
33Keratoconjunctivitis sicca (HP:0001097)3.17826775
34Agammaglobulinemia (HP:0004432)3.17470263
35Increased IgE level (HP:0003212)3.17058288
36Inflammation of the large intestine (HP:0002037)3.14981102
37Increased IgM level (HP:0003496)3.14232772
38Recurrent bronchitis (HP:0002837)3.13860501
39Hemoptysis (HP:0002105)3.04165089
40Gastrointestinal inflammation (HP:0004386)3.03154588
41Chest pain (HP:0100749)3.01162911
42Autoimmune hemolytic anemia (HP:0001890)3.00385398
43Leukocytosis (HP:0001974)2.97699235
44Colitis (HP:0002583)2.97407139
45Cellulitis (HP:0100658)2.94520054
46Keratoconjunctivitis (HP:0001096)2.92916787
47Granulocytopenia (HP:0001913)2.83815072
48Prolonged bleeding time (HP:0003010)2.80713709
49Urticaria (HP:0001025)2.78949982
50Gingival bleeding (HP:0000225)2.74329361
51Abnormality of T cell physiology (HP:0011840)2.72598107
52Hypergammaglobulinemia (HP:0010702)2.66292841
53Chronic diarrhea (HP:0002028)2.63564915
54Epistaxis (HP:0000421)2.63196767
55Eosinophilia (HP:0001880)2.62223751
56Systemic lupus erythematosus (HP:0002725)2.59638774
57Pulmonary embolism (HP:0002204)2.58769826
58Lymphopenia (HP:0001888)2.56602252
59Arterial thrombosis (HP:0004420)2.56101776
60Abnormality of cells of the lymphoid lineage (HP:0012140)2.56017052
61Peritonitis (HP:0002586)2.50202999
62IgG deficiency (HP:0004315)2.47767819
63Hypochromic anemia (HP:0001931)2.46174338
64Osteomyelitis (HP:0002754)2.42167657
65Abnormality of eosinophils (HP:0001879)2.38955285
66Severe combined immunodeficiency (HP:0004430)2.34979432
67Fatigue (HP:0012378)2.34392459
68Chronic otitis media (HP:0000389)2.32448946
69Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.32348982
70Gastrointestinal stroma tumor (HP:0100723)2.32132835
71Acute hepatic failure (HP:0006554)2.29940542
72Papilledema (HP:0001085)2.29176721
73Autoimmune thrombocytopenia (HP:0001973)2.28941872
74Papilloma (HP:0012740)2.26397026
75Verrucae (HP:0200043)2.26397026
76IgM deficiency (HP:0002850)2.26020220
77Anorexia (HP:0002039)2.21836294
78Abnormality of the pleura (HP:0002103)2.18868080
79Gangrene (HP:0100758)2.18462381
80Abnormality of the peritoneum (HP:0002585)2.14670881
81Slow saccadic eye movements (HP:0000514)2.12597056
82Viral hepatitis (HP:0006562)2.11205623
83Purpura (HP:0000979)2.09172753
84Joint swelling (HP:0001386)2.08293619
85Sepsis (HP:0100806)2.07040169
86Skin ulcer (HP:0200042)2.06047795
87Hypochromic microcytic anemia (HP:0004840)2.05749335
88Petechiae (HP:0000967)2.05248547
89Glomerulopathy (HP:0100820)2.03803653
90Interstitial pulmonary disease (HP:0006530)2.02963059
91Emphysema (HP:0002097)1.99547738
92Abnormality of the fingertips (HP:0001211)1.99543662
93Skin rash (HP:0000988)1.98908685
94Malnutrition (HP:0004395)1.98046375
95Nasal polyposis (HP:0100582)1.96298645
96Restrictive lung disease (HP:0002091)1.94492129
97Microcytic anemia (HP:0001935)1.93268747
98Episodic fever (HP:0001954)1.93125145
99Amyloidosis (HP:0011034)1.89498771
100Hematochezia (HP:0002573)1.87461697

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.40940745
2RIPK43.97497824
3TYK23.32089176
4TXK2.86467253
5BLK2.65567377
6PRPF4B2.51762387
7FES2.43566711
8ERN12.37407105
9CSK2.34285441
10ZAP702.26944549
11JAK32.24485267
12JAK12.18138208
13GRK62.12924368
14IKBKE2.12269210
15IRAK42.07975869
16MAP3K141.96378227
17MAP2K31.95634955
18BTK1.94993208
19MAP3K131.94407626
20FGFR41.92295461
21EPHB11.84042722
22SYK1.76445900
23TAOK31.73049155
24TNK21.68555114
25ITK1.63058181
26TBK11.62146150
27HCK1.55017340
28KIT1.53991411
29FGFR31.46237192
30LCK1.38131751
31LYN1.32800271
32TEC1.31632186
33CSF1R1.30222190
34MAP3K31.29643522
35JAK21.29090373
36BMPR21.24058094
37MARK31.23754027
38FGR1.18135819
39MAP3K111.13665889
40SIK31.13193511
41STK101.10527599
42TGFBR21.08784897
43MAP3K11.05903043
44NLK1.04448012
45TRIB30.99898659
46CAMKK20.98876797
47IKBKB0.96413024
48MAP3K100.95917572
49TAOK10.95255379
50CDC42BPA0.90669481
51EPHA30.90486119
52PDK10.81505909
53PTK60.75388431
54MAPK120.75128481
55MAP3K70.74362620
56CAMKK10.73088633
57SIK20.72485383
58MAPK70.72204100
59MARK20.72041285
60HIPK20.71828907
61LRRK20.71728832
62YES10.71264927
63PRKCQ0.69904801
64IRAK10.67968673
65PRKD20.66582973
66PIM10.66378628
67MAPK110.64561900
68GRK70.64299474
69KSR20.63973749
70FYN0.63276636
71RIPK10.62993752
72PIK3CG0.59493778
73MATK0.58938726
74PDPK10.56249124
75TESK20.55844276
76TAOK20.54720500
77PTK2B0.50915593
78CDK40.50757406
79RET0.47093245
80SMG10.46422125
81NEK90.45000709
82SIK10.44854850
83MAP3K20.42798311
84KDR0.41519786
85CDK60.40763198
86MAP3K60.40516780
87STK380.39331946
88PDGFRB0.39319771
89DYRK1B0.39274641
90TRPM70.39034777
91MELK0.37155778
92SGK30.36497783
93MAPKAPK20.34787906
94PRKCH0.34611868
95STK110.33554315
96MAP2K60.30979688
97MAP3K50.28297629
98CDK120.28184280
99RPS6KL10.27584946
100RPS6KC10.27584946

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.26296981
2Allograft rejection_Homo sapiens_hsa053303.10199150
3Graft-versus-host disease_Homo sapiens_hsa053323.09107744
4Autoimmune thyroid disease_Homo sapiens_hsa053202.94317633
5Leishmaniasis_Homo sapiens_hsa051402.73442859
6Staphylococcus aureus infection_Homo sapiens_hsa051502.69668399
7Osteoclast differentiation_Homo sapiens_hsa043802.46517417
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.32145970
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.31185990
10Antigen processing and presentation_Homo sapiens_hsa046122.24430961
11Type I diabetes mellitus_Homo sapiens_hsa049402.21464772
12B cell receptor signaling pathway_Homo sapiens_hsa046622.14657971
13Intestinal immune network for IgA production_Homo sapiens_hsa046722.06117947
14T cell receptor signaling pathway_Homo sapiens_hsa046602.00752952
15Measles_Homo sapiens_hsa051622.00508643
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.95677810
17Asthma_Homo sapiens_hsa053101.88907487
18Viral myocarditis_Homo sapiens_hsa054161.85992389
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.82330379
20Hematopoietic cell lineage_Homo sapiens_hsa046401.79781318
21Tuberculosis_Homo sapiens_hsa051521.73294140
22Toxoplasmosis_Homo sapiens_hsa051451.64994507
23Influenza A_Homo sapiens_hsa051641.62619832
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.60339765
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.57133783
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.56509466
27Malaria_Homo sapiens_hsa051441.56440598
28Herpes simplex infection_Homo sapiens_hsa051681.52273331
29Acute myeloid leukemia_Homo sapiens_hsa052211.48863631
30Chemokine signaling pathway_Homo sapiens_hsa040621.45129558
31Jak-STAT signaling pathway_Homo sapiens_hsa046301.43961324
32Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.38093715
33TNF signaling pathway_Homo sapiens_hsa046681.29374163
34Other glycan degradation_Homo sapiens_hsa005111.23426576
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.22810546
36Hepatitis C_Homo sapiens_hsa051601.16955511
37Hepatitis B_Homo sapiens_hsa051611.12524204
38Leukocyte transendothelial migration_Homo sapiens_hsa046701.12475937
39African trypanosomiasis_Homo sapiens_hsa051431.10344648
40Non-small cell lung cancer_Homo sapiens_hsa052231.09358540
41Pertussis_Homo sapiens_hsa051331.08597972
42Platelet activation_Homo sapiens_hsa046111.05561137
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.00422164
44Phagosome_Homo sapiens_hsa041450.99768333
45Rheumatoid arthritis_Homo sapiens_hsa053230.98761771
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.96404012
47Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.94675326
48Pancreatic cancer_Homo sapiens_hsa052120.94127698
49Legionellosis_Homo sapiens_hsa051340.92507433
50Apoptosis_Homo sapiens_hsa042100.88960509
51Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88846358
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84848371
53Chronic myeloid leukemia_Homo sapiens_hsa052200.79582249
54VEGF signaling pathway_Homo sapiens_hsa043700.77584500
55Prolactin signaling pathway_Homo sapiens_hsa049170.76320271
56Shigellosis_Homo sapiens_hsa051310.67408734
57Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67139412
58HTLV-I infection_Homo sapiens_hsa051660.63066339
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.62528707
60Epstein-Barr virus infection_Homo sapiens_hsa051690.62406538
61Renal cell carcinoma_Homo sapiens_hsa052110.61395038
62Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60844464
63Adipocytokine signaling pathway_Homo sapiens_hsa049200.59283879
64FoxO signaling pathway_Homo sapiens_hsa040680.58967726
65Salmonella infection_Homo sapiens_hsa051320.58637762
66Endocytosis_Homo sapiens_hsa041440.56931293
67Viral carcinogenesis_Homo sapiens_hsa052030.55247929
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54450837
69Insulin resistance_Homo sapiens_hsa049310.54224361
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.53332000
71Choline metabolism in cancer_Homo sapiens_hsa052310.51392343
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.51334710
73Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.49956417
74Complement and coagulation cascades_Homo sapiens_hsa046100.48609735
75Dorso-ventral axis formation_Homo sapiens_hsa043200.47863310
76Amoebiasis_Homo sapiens_hsa051460.47726250
77Notch signaling pathway_Homo sapiens_hsa043300.47106583
78Lysosome_Homo sapiens_hsa041420.46877759
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.46184662
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45597355
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43693691
82GnRH signaling pathway_Homo sapiens_hsa049120.42229178
83mTOR signaling pathway_Homo sapiens_hsa041500.42027302
84Endometrial cancer_Homo sapiens_hsa052130.41762872
85Inositol phosphate metabolism_Homo sapiens_hsa005620.40744753
86Colorectal cancer_Homo sapiens_hsa052100.39616339
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.37064005
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34410168
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34302122
90HIF-1 signaling pathway_Homo sapiens_hsa040660.33294203
91MAPK signaling pathway_Homo sapiens_hsa040100.31892337
92Prostate cancer_Homo sapiens_hsa052150.31324007
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31321221
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27496980
95Renin-angiotensin system_Homo sapiens_hsa046140.26564341
96Ras signaling pathway_Homo sapiens_hsa040140.23787705
97Small cell lung cancer_Homo sapiens_hsa052220.23021291
98Rap1 signaling pathway_Homo sapiens_hsa040150.22306174
99Arachidonic acid metabolism_Homo sapiens_hsa005900.22070165
100ABC transporters_Homo sapiens_hsa020100.22026982

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