BTNL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)7.82813294
2regulation of guanylate cyclase activity (GO:0031282)7.59988676
3NADH metabolic process (GO:0006734)6.60594520
4intestinal absorption (GO:0050892)6.49321067
5epoxygenase P450 pathway (GO:0019373)5.95628118
6fat-soluble vitamin biosynthetic process (GO:0042362)5.87432859
7lipoprotein transport (GO:0042953)5.69342487
8positive regulation of guanylate cyclase activity (GO:0031284)5.51248163
9regulation of cellular extravasation (GO:0002691)5.42006016
10regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)5.20203417
11endocrine process (GO:0050886)5.20203417
12regulation of systemic arterial blood pressure by hormone (GO:0001990)5.20203417
13fructose metabolic process (GO:0006000)5.18488477
14hormone catabolic process (GO:0042447)5.03817812
15regulation of bile acid biosynthetic process (GO:0070857)4.97395428
16receptor guanylyl cyclase signaling pathway (GO:0007168)4.76265509
17regulation of systemic arterial blood pressure (GO:0003073)4.70876909
18diacylglycerol metabolic process (GO:0046339)4.62211794
19regulation of cGMP biosynthetic process (GO:0030826)4.58190188
20drug metabolic process (GO:0017144)4.43978584
21maintenance of gastrointestinal epithelium (GO:0030277)4.39913682
22renal system process involved in regulation of blood volume (GO:0001977)4.37567335
23positive regulation of pseudopodium assembly (GO:0031274)4.35633752
24antibacterial humoral response (GO:0019731)4.35216276
25adhesion of symbiont to host cell (GO:0044650)4.28349614
26virion attachment to host cell (GO:0019062)4.28349614
27antimicrobial humoral response (GO:0019730)4.27033257
28bile acid and bile salt transport (GO:0015721)4.25942666
29peptide catabolic process (GO:0043171)4.22360034
30regulation of vitamin metabolic process (GO:0030656)4.17092029
31cellular glucuronidation (GO:0052695)4.16737178
32urea cycle (GO:0000050)4.11838290
33glucuronate metabolic process (GO:0019585)4.11016706
34uronic acid metabolic process (GO:0006063)4.11016706
35very-low-density lipoprotein particle assembly (GO:0034379)4.09538326
36regulation of triglyceride catabolic process (GO:0010896)4.01630889
37peptide hormone processing (GO:0016486)3.98786123
38positive regulation of respiratory burst (GO:0060267)3.96855235
39urea metabolic process (GO:0019627)3.91850169
40antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.90209809
41regulation of pseudopodium assembly (GO:0031272)3.89950407
42antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.84786277
43regulation of cGMP metabolic process (GO:0030823)3.78238697
44glycosphingolipid catabolic process (GO:0046479)3.76351679
45antigen processing and presentation of endogenous antigen (GO:0019883)3.75122459
46glycolipid catabolic process (GO:0019377)3.72600584
47digestion (GO:0007586)3.72034718
48plasma lipoprotein particle assembly (GO:0034377)3.64744080
49cGMP-mediated signaling (GO:0019934)3.64384915
50nitrogen cycle metabolic process (GO:0071941)3.61442201
51adhesion of symbiont to host (GO:0044406)3.61298728
52vitamin transmembrane transport (GO:0035461)3.56698304
53alkaloid metabolic process (GO:0009820)3.56362707
54flavonoid metabolic process (GO:0009812)3.52303152
55positive regulation of glycoprotein biosynthetic process (GO:0010560)3.48928737
56cellular response to nitric oxide (GO:0071732)3.45966319
57nucleoside diphosphate biosynthetic process (GO:0009133)3.34811772
58phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.33847163
59protein-lipid complex assembly (GO:0065005)3.33823483
60digestive system process (GO:0022600)3.33813100
61vitamin A metabolic process (GO:0006776)3.31235270
62response to nitric oxide (GO:0071731)3.26872958
63vitamin transport (GO:0051180)3.26665669
64positive regulation of Cdc42 GTPase activity (GO:0043089)3.26528548
65sulfate transmembrane transport (GO:1902358)3.25093998
66cellular response to reactive nitrogen species (GO:1902170)3.20077082
67drug catabolic process (GO:0042737)3.19830508
68epithelial structure maintenance (GO:0010669)3.19543250
69positive regulation of glycoprotein metabolic process (GO:1903020)3.18373571
70glomerular filtration (GO:0003094)3.14900031
71calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.14822665
72positive regulation of cGMP biosynthetic process (GO:0030828)3.13859958
73actin filament depolymerization (GO:0030042)3.13266836
74fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.13206327
75arginine metabolic process (GO:0006525)3.12076899
76lipoprotein metabolic process (GO:0042157)3.11740420
77transcytosis (GO:0045056)3.09873625
78renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.09001431
79positive regulation of lipid catabolic process (GO:0050996)3.08385234
80leukotriene metabolic process (GO:0006691)3.07558187
81drinking behavior (GO:0042756)3.05480016
82homocysteine metabolic process (GO:0050667)3.03803151
83glycerol metabolic process (GO:0006071)3.02847898
84glycosylceramide metabolic process (GO:0006677)3.02676215
85sexual reproduction (GO:0019953)3.01143799
86ceramide catabolic process (GO:0046514)3.01090615
87ethanol oxidation (GO:0006069)2.99692113
88drug transport (GO:0015893)2.98809408
89glutamine family amino acid biosynthetic process (GO:0009084)2.96978838
90fat-soluble vitamin metabolic process (GO:0006775)2.96060586
91bile acid metabolic process (GO:0008206)2.95409377
92exogenous drug catabolic process (GO:0042738)2.95237480
93cGMP biosynthetic process (GO:0006182)2.93140326
94phospholipid efflux (GO:0033700)2.92941135
95sphingolipid catabolic process (GO:0030149)2.91613039
96positive regulation of triglyceride lipase activity (GO:0061365)2.90963652
97positive regulation of lipoprotein lipase activity (GO:0051006)2.90963652
98sphingomyelin metabolic process (GO:0006684)2.88568592
99regulation of cholesterol homeostasis (GO:2000188)2.87039839
100angiotensin maturation (GO:0002003)10.0081707

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CDX2_20551321_ChIP-Seq_CACO-2_Human4.86941467
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.13522421
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.47798651
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.45923256
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.26346925
6SOX2_27498859_Chip-Seq_STOMACH_Mouse2.83021098
7GATA4_25053715_ChIP-Seq_YYC3_Human2.64274487
8HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.61864971
9CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.53206130
10RXR_22158963_ChIP-Seq_LIVER_Mouse2.44197347
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.42488227
12PPARA_22158963_ChIP-Seq_LIVER_Mouse2.36504929
13GATA6_25053715_ChIP-Seq_YYC3_Human2.34101190
14RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.20509988
15SOX2_20726797_ChIP-Seq_SW620_Human2.13957349
16LXR_22158963_ChIP-Seq_LIVER_Mouse2.13697811
17GATA1_22025678_ChIP-Seq_K562_Human1.99035451
18CDX2_19796622_ChIP-Seq_MESCs_Mouse1.92403258
19EGR1_23403033_ChIP-Seq_LIVER_Mouse1.91587377
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.90983591
21MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.88252075
22TP63_17297297_ChIP-ChIP_HaCaT_Human1.85635347
23LXR_22292898_ChIP-Seq_THP-1_Human1.82521225
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.82515114
25NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.81057139
26FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.79400852
27IRF8_21731497_ChIP-ChIP_J774_Mouse1.78336283
28BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.72339133
29PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.70419446
30FOXO3_23340844_ChIP-Seq_DLD1_Human1.66841481
31FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.59224888
32TRIM28_21343339_ChIP-Seq_HEK293_Human1.48533975
33RACK7_27058665_Chip-Seq_MCF-7_Human1.44045033
34KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.43360109
35BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.42368489
36PPAR_26484153_Chip-Seq_NCI-H1993_Human1.36620841
37CLOCK_20551151_ChIP-Seq_293T_Human1.35892831
38AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.34082575
39STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.33318551
40ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.29718762
41VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.26372353
42SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.25660876
43TCF4_18268006_ChIP-ChIP_LS174T_Human1.24024341
44CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23720155
45VDR_24763502_ChIP-Seq_THP-1_Human1.22366264
46KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.21578481
47ESR1_21235772_ChIP-Seq_MCF-7_Human1.20910930
48SA1_27219007_Chip-Seq_Bcells_Human1.20876652
49* BCL6_27268052_Chip-Seq_Bcells_Human1.19656243
50TET1_21451524_ChIP-Seq_MESCs_Mouse1.19051164
51GATA2_19941826_ChIP-Seq_K562_Human1.17384121
52* BCOR_27268052_Chip-Seq_Bcells_Human1.15968573
53GATA1_19941826_ChIP-Seq_K562_Human1.15820447
54ESR2_21235772_ChIP-Seq_MCF-7_Human1.15308297
55KLF5_25053715_ChIP-Seq_YYC3_Human1.14380114
56ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13188745
57IRF8_27001747_Chip-Seq_BMDM_Mouse1.11460432
58* HNF4A_19822575_ChIP-Seq_HepG2_Human1.10844231
59JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.10558982
60NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.09775500
61SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09271857
62CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09261623
63NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.08696495
64P63_26484246_Chip-Seq_KERATINOCYTES_Human1.08184991
65GATA2_22383799_ChIP-Seq_G1ME_Mouse1.07128772
66FOXA1_25552417_ChIP-Seq_VCAP_Human1.05051233
67EGR1_19032775_ChIP-ChIP_M12_Human1.04869377
68RARG_19884340_ChIP-ChIP_MEFs_Mouse1.04725746
69CDX2_22108803_ChIP-Seq_LS180_Human1.01567825
70VDR_24787735_ChIP-Seq_THP-1_Human1.00612354
71SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00529155
72RUNX1_27514584_Chip-Seq_MCF-7_Human0.99108934
73GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98992658
74NANOG_20526341_ChIP-Seq_ESCs_Human0.98768120
75CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.97489289
76FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.96607540
77TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95946020
78TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95879129
79E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.95679527
80VDR_21846776_ChIP-Seq_THP-1_Human0.95303459
81GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.91697701
82EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.91458073
83DNAJC2_21179169_ChIP-ChIP_NT2_Human0.90827855
84CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.90471233
85SRY_22984422_ChIP-ChIP_TESTIS_Rat0.90321950
86RXR_22108803_ChIP-Seq_LS180_Human0.90300150
87DROSHA_22980978_ChIP-Seq_HELA_Human0.90059087
88SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.89765139
89CEBPB_22108803_ChIP-Seq_LS180_Human0.89713880
90STAT1_20625510_ChIP-Seq_HELA_Human0.89362676
91FOXA2_19822575_ChIP-Seq_HepG2_Human0.88210969
92* CTCF_27219007_Chip-Seq_Bcells_Human0.86699834
93PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.85331124
94ELK3_25401928_ChIP-Seq_HUVEC_Human0.84906705
95PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84305228
96CREB1_26743006_Chip-Seq_LNCaP_Human0.84121648
97RAD21_21589869_ChIP-Seq_MESCs_Mouse0.82695406
98FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82667427
99MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.82630721
100Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.81441988

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.87472058
2MP0005085_abnormal_gallbladder_physiolo4.36342917
3MP0002139_abnormal_hepatobiliary_system4.34251712
4MP0001666_abnormal_nutrient_absorption4.32280006
5MP0003183_abnormal_peptide_metabolism4.01731993
6MP0009379_abnormal_foot_pigmentation3.70164633
7MP0005365_abnormal_bile_salt3.18421666
8MP0004019_abnormal_vitamin_homeostasis3.15649350
9MP0010234_abnormal_vibrissa_follicle3.07111529
10MP0010155_abnormal_intestine_physiology3.06878256
11MP0004264_abnormal_extraembryonic_tissu3.03135534
12MP0004147_increased_porphyrin_level2.97926369
13MP0009840_abnormal_foam_cell2.95259581
14MP0003866_abnormal_defecation2.54114280
15MP0001664_abnormal_digestion2.10545613
16MP0005409_darkened_coat_color2.09838826
17MP0000490_abnormal_crypts_of2.06027056
18MP0003868_abnormal_feces_composition1.92466843
19MP0010352_gastrointestinal_tract_polyps1.84006689
20MP0010329_abnormal_lipoprotein_level1.79600313
21MP0009643_abnormal_urine_homeostasis1.69240099
22MP0005166_decreased_susceptibility_to1.66421408
23MP0000477_abnormal_intestine_morphology1.62179944
24MP0005332_abnormal_amino_acid1.61502816
25MP0000678_abnormal_parathyroid_gland1.59862503
26MP0001765_abnormal_ion_homeostasis1.59173663
27MP0003724_increased_susceptibility_to1.56348960
28MP0001873_stomach_inflammation1.54457674
29MP0001663_abnormal_digestive_system1.53322205
30MP0003252_abnormal_bile_duct1.47802128
31MP0004858_abnormal_nervous_system1.41011195
32MP0004043_abnormal_pH_regulation1.38727956
33MP0000538_abnormal_urinary_bladder1.37442402
34MP0001188_hyperpigmentation1.34786562
35MP0001764_abnormal_homeostasis1.33712135
36MP0002876_abnormal_thyroid_physiology1.32170875
37MP0005381_digestive/alimentary_phenotyp1.25576298
38MP0005636_abnormal_mineral_homeostasis1.25400832
39MP0003806_abnormal_nucleotide_metabolis1.23243629
40MP0003303_peritoneal_inflammation1.23088457
41MP0005670_abnormal_white_adipose1.23029701
42MP0002136_abnormal_kidney_physiology1.22448031
43MP0004782_abnormal_surfactant_physiolog1.18296083
44MP0009785_altered_susceptibility_to1.17696237
45MP0003879_abnormal_hair_cell1.17436181
46MP0003436_decreased_susceptibility_to1.17371969
47MP0001835_abnormal_antigen_presentation1.15273298
48MP0002138_abnormal_hepatobiliary_system1.14422022
49MP0005451_abnormal_body_composition1.13850070
50MP0001845_abnormal_inflammatory_respons1.11004757
51MP0002118_abnormal_lipid_homeostasis1.09126645
52MP0000462_abnormal_digestive_system1.06374439
53MP0000465_gastrointestinal_hemorrhage1.05782517
54MP0003300_gastrointestinal_ulcer1.04399596
55MP0005025_abnormal_response_to1.03120678
56MP0003191_abnormal_cellular_cholesterol0.98034469
57MP0000609_abnormal_liver_physiology0.96585539
58MP0001501_abnormal_sleep_pattern0.94059393
59MP0005535_abnormal_body_temperature0.92004349
60MP0002796_impaired_skin_barrier0.91131469
61MP0001790_abnormal_immune_system0.90884726
62MP0005387_immune_system_phenotype0.90884726
63MP0002166_altered_tumor_susceptibility0.89545429
64MP0000230_abnormal_systemic_arterial0.89180490
65MP0005448_abnormal_energy_balance0.88811053
66MP0002971_abnormal_brown_adipose0.87953448
67MP0001756_abnormal_urination0.87777808
68MP0002822_catalepsy0.87455931
69MP0006082_CNS_inflammation0.86681484
70MP0005584_abnormal_enzyme/coenzyme_acti0.85668811
71MP0008469_abnormal_protein_level0.83494219
72MP0004270_analgesia0.81248678
73MP0005319_abnormal_enzyme/_coenzyme0.81131023
74MP0002098_abnormal_vibrissa_morphology0.80174073
75MP0009333_abnormal_splenocyte_physiolog0.80168412
76MP0004947_skin_inflammation0.77438876
77MP0009115_abnormal_fat_cell0.76700928
78MP0002148_abnormal_hypersensitivity_rea0.75356916
79MP0002396_abnormal_hematopoietic_system0.74650891
80MP0001800_abnormal_humoral_immune0.74389039
81MP0005671_abnormal_response_to0.73526471
82MP0003718_maternal_effect0.73155488
83MP0000537_abnormal_urethra_morphology0.70395628
84MP0009764_decreased_sensitivity_to0.70208167
85MP0005310_abnormal_salivary_gland0.69663221
86MP0001533_abnormal_skeleton_physiology0.68944900
87MP0009642_abnormal_blood_homeostasis0.67549764
88MP0000249_abnormal_blood_vessel0.65557127
89MP0008260_abnormal_autophagy0.64957260
90MP0005666_abnormal_adipose_tissue0.62482878
91MP0005000_abnormal_immune_tolerance0.62225636
92MP0002419_abnormal_innate_immunity0.59996008
93MP0000604_amyloidosis0.59373232
94MP0000685_abnormal_immune_system0.58134687
95MP0002006_tumorigenesis0.57833552
96MP0002723_abnormal_immune_serum0.57452742
97MP0005501_abnormal_skin_physiology0.56751234
98MP0001485_abnormal_pinna_reflex0.56246854
99MP0002452_abnormal_antigen_presenting0.56236472
100MP0003329_amyloid_beta_deposits0.54489256

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glutamine family amino acid metabolism (HP:0010902)9.44468843
2Malnutrition (HP:0004395)7.01241959
3Hydroxyprolinuria (HP:0003080)6.53392513
4Abnormality of proline metabolism (HP:0010907)6.53392513
5Chronic diarrhea (HP:0002028)5.17022048
6Abnormality of the vitamin B12 metabolism (HP:0004341)4.74695593
7Ileus (HP:0002595)4.72525600
8Abnormality of vitamin B metabolism (HP:0004340)4.42295038
9Hyperactive renin-angiotensin system (HP:0000841)4.36166700
10Hypobetalipoproteinemia (HP:0003563)4.32505390
11Widely patent fontanelles and sutures (HP:0004492)4.22886575
12Metabolic alkalosis (HP:0200114)4.22269142
13Systemic lupus erythematosus (HP:0002725)4.19760328
14Decreased circulating renin level (HP:0003351)4.13022566
15Confusion (HP:0001289)4.05834897
16Fat malabsorption (HP:0002630)4.04545854
17Acanthocytosis (HP:0001927)3.62292521
18Abnormality of vitamin metabolism (HP:0100508)3.55217207
19Alkalosis (HP:0001948)3.50593745
20Abnormality of renin-angiotensin system (HP:0000847)3.50157979
21Eczematoid dermatitis (HP:0000976)3.46345551
22Hyperglycinuria (HP:0003108)3.32235685
23Nausea (HP:0002018)3.31772048
24Thin bony cortex (HP:0002753)3.30966740
25Abdominal distention (HP:0003270)3.26884972
26Abnormality of monocarboxylic acid metabolism (HP:0010996)3.18667954
27Wide cranial sutures (HP:0010537)3.10970408
28Congenital sensorineural hearing impairment (HP:0008527)3.08627199
29Glycosuria (HP:0003076)3.08609836
30Abnormality of urine glucose concentration (HP:0011016)3.08609836
31Pigmentary retinal degeneration (HP:0001146)3.07115333
32Proximal tubulopathy (HP:0000114)3.01786084
33Abnormality of glycine metabolism (HP:0010895)2.85851432
34Abnormality of serine family amino acid metabolism (HP:0010894)2.85851432
35Nephrolithiasis (HP:0000787)2.82321313
36Hemorrhage of the eye (HP:0011885)2.77913323
37Abnormality of small intestinal villus morphology (HP:0011472)2.77511868
38Villous atrophy (HP:0011473)2.77511868
39Hypophosphatemia (HP:0002148)2.76077555
40Hyperparathyroidism (HP:0000843)2.75922437
41Xanthomatosis (HP:0000991)2.71101214
42Facial shape deformation (HP:0011334)2.60139004
43Potter facies (HP:0002009)2.60139004
44Increased purine levels (HP:0004368)2.58568313
45Hyperuricemia (HP:0002149)2.58568313
46Flat acetabular roof (HP:0003180)2.56875338
47Posterior subcapsular cataract (HP:0007787)2.52906343
48Steatorrhea (HP:0002570)2.50304212
49Hyperammonemia (HP:0001987)2.49266259
50Megaloblastic anemia (HP:0001889)2.47036830
51Hypotension (HP:0002615)2.39544282
52Right ventricular cardiomyopathy (HP:0011663)2.38787007
53Gingivitis (HP:0000230)2.36384760
54Focal segmental glomerulosclerosis (HP:0000097)2.36318333
55Enlarged epiphyses (HP:0010580)2.27267482
56Glomerulonephritis (HP:0000099)2.25139764
57Abnormality of purine metabolism (HP:0004352)2.24386286
58Hyperphosphatemia (HP:0002905)2.23127593
59Abnormal urine phosphate concentration (HP:0012599)2.18104319
60Delayed epiphyseal ossification (HP:0002663)2.14793985
61Abnormality of the costochondral junction (HP:0000919)2.13994432
62Abnormality of nucleobase metabolism (HP:0010932)2.12516172
63Hypolipoproteinemia (HP:0010981)2.12180081
64Abnormality of aspartate family amino acid metabolism (HP:0010899)2.10003486
65Gastrointestinal dysmotility (HP:0002579)2.07483150
66Abnormality of complement system (HP:0005339)2.07349692
67Hyperphosphaturia (HP:0003109)2.06253265
68Renal tubular acidosis (HP:0001947)2.05752407
69Pancreatitis (HP:0001733)2.05602787
70Hyperaldosteronism (HP:0000859)2.05442705
71Abnormality of chloride homeostasis (HP:0011422)2.03469405
72Abnormality of dicarboxylic acid metabolism (HP:0010995)2.03109136
73Dicarboxylic aciduria (HP:0003215)2.03109136
74Cerebral palsy (HP:0100021)2.02635003
75Petechiae (HP:0000967)1.98982547
76Metabolic acidosis (HP:0001942)1.98401092
77Nephritis (HP:0000123)1.97923168
78Hypokalemia (HP:0002900)1.97187933
79Protuberant abdomen (HP:0001538)1.96972001
80Growth hormone excess (HP:0000845)1.96320140
81Segmental peripheral demyelination/remyelination (HP:0003481)1.95823084
82Abnormality of magnesium homeostasis (HP:0004921)1.91561274
83Complement deficiency (HP:0004431)1.89967263
84Abnormality of pyrimidine metabolism (HP:0004353)1.86617741
85Subcapsular cataract (HP:0000523)1.86293000
86Pili torti (HP:0003777)1.82691217
87Abnormal glucose tolerance (HP:0001952)1.80487350
88Glomerulosclerosis (HP:0000096)1.77098053
89Multiple lipomas (HP:0001012)1.77021725
90Dehydration (HP:0001944)1.76372244
91Epidermoid cyst (HP:0200040)1.76058984
92Intrahepatic cholestasis (HP:0001406)1.74672033
93Abnormal enzyme/coenzyme activity (HP:0012379)1.73181459
94Abnormality of alkaline phosphatase activity (HP:0004379)1.72784848
95Hypocalcemia (HP:0002901)1.72469379
96Conjugated hyperbilirubinemia (HP:0002908)1.72050164
97Bone pain (HP:0002653)1.71189714
98Irritability (HP:0000737)1.71050438
99Abnormal tarsal ossification (HP:0008369)1.70795126
100Abnormality of potassium homeostasis (HP:0011042)1.69023536

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B7.10024505
2ERN14.91400505
3MST1R4.64336415
4RIPK13.63060816
5PRKG23.24125950
6EPHA22.89178373
7MAP3K102.68303412
8RIPK42.23846410
9PIK3CA2.08801544
10TESK22.01975432
11TYK21.91923014
12PTK61.87959646
13MAP4K11.86844985
14EPHB11.82848592
15FGFR41.77788102
16GRK61.66679334
17EPHB21.62012122
18MET1.57856328
19EPHA31.48150413
20STK391.43045637
21MAP3K121.42372933
22MAP3K21.42290009
23PRPF4B1.39038622
24OXSR11.38157155
25MAP3K11.33521361
26PDK21.30859022
27LMTK21.27037324
28MATK1.23913386
29DDR21.14307244
30STK241.14109855
31MAP2K21.12202966
32TAOK11.05727540
33MAP3K111.04456101
34PDPK10.96587225
35MYLK0.94069282
36TNIK0.93989492
37FGFR30.93923560
38TESK10.92620009
39NLK0.91253231
40CDC42BPA0.90263910
41CSK0.87527576
42TBK10.80926566
43MST40.80229804
44IRAK40.80224094
45MAP2K60.79988199
46ERBB20.78146992
47EPHA40.75991739
48ZAP700.74334103
49PDK10.73557683
50IKBKE0.70414059
51KSR20.67643052
52CDK190.66665826
53DYRK1B0.65939827
54IRAK10.65401219
55JAK20.64736544
56MAP3K30.62485279
57PRKAA20.61905735
58JAK10.60723490
59YES10.60170691
60PRKACG0.59807249
61BMPR20.59573308
62MAP3K140.57963665
63AKT30.57227480
64MAPK110.55966778
65PRKCZ0.55225045
66JAK30.54438609
67BTK0.54168956
68PIM10.53328975
69TRIB30.51025046
70FER0.49886921
71FYN0.48524013
72RET0.48024607
73SYK0.48005668
74CSF1R0.47708710
75PRKCA0.47684051
76LYN0.46886164
77PAK40.46229671
78ITK0.45433598
79BLK0.44911474
80SRC0.44000155
81CAMK2D0.41561892
82SMG10.38229442
83ABL20.37476363
84FGR0.36577401
85KIT0.35746679
86PRKCD0.34246640
87PTK20.32580400
88LCK0.32246656
89RPS6KA20.31200582
90DAPK20.30696010
91BMX0.29312146
92LRRK20.28249640
93MAPKAPK20.27767611
94TEC0.27757261
95PRKCQ0.26510765
96DMPK0.25298176
97MAP3K80.23782126
98HCK0.22116717
99MAPK70.21690324
100CDK60.21572869

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004604.96960484
2Fat digestion and absorption_Homo sapiens_hsa049754.18289411
3Vitamin digestion and absorption_Homo sapiens_hsa049773.92331133
4Renin-angiotensin system_Homo sapiens_hsa046143.80292053
5Mineral absorption_Homo sapiens_hsa049782.75282367
6Protein digestion and absorption_Homo sapiens_hsa049742.30167484
7Caffeine metabolism_Homo sapiens_hsa002322.26731276
8Sulfur metabolism_Homo sapiens_hsa009202.25471262
9Arginine biosynthesis_Homo sapiens_hsa002202.23106458
10Histidine metabolism_Homo sapiens_hsa003402.19125878
11Fructose and mannose metabolism_Homo sapiens_hsa000512.14095116
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.11308487
13Starch and sucrose metabolism_Homo sapiens_hsa005002.09834803
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.04348967
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.01528619
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.96695356
17Pentose and glucuronate interconversions_Homo sapiens_hsa000401.93002888
18Carbohydrate digestion and absorption_Homo sapiens_hsa049731.83415623
19Galactose metabolism_Homo sapiens_hsa000521.77778500
20Chemical carcinogenesis_Homo sapiens_hsa052041.74295295
21Retinol metabolism_Homo sapiens_hsa008301.73084450
22Linoleic acid metabolism_Homo sapiens_hsa005911.72358640
23Drug metabolism - other enzymes_Homo sapiens_hsa009831.70687241
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.68645170
25Bile secretion_Homo sapiens_hsa049761.66597347
26PPAR signaling pathway_Homo sapiens_hsa033201.65330190
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.60730927
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.52918955
29Asthma_Homo sapiens_hsa053101.46256618
30Arachidonic acid metabolism_Homo sapiens_hsa005901.32775193
31Glycerolipid metabolism_Homo sapiens_hsa005611.32182375
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.29927482
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.29492806
34Arginine and proline metabolism_Homo sapiens_hsa003301.24662777
35Allograft rejection_Homo sapiens_hsa053301.20239509
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.18003401
37Fatty acid degradation_Homo sapiens_hsa000711.17640433
38Autoimmune thyroid disease_Homo sapiens_hsa053201.12324473
39Maturity onset diabetes of the young_Homo sapiens_hsa049501.12279444
40Graft-versus-host disease_Homo sapiens_hsa053321.09926090
41Staphylococcus aureus infection_Homo sapiens_hsa051501.07721994
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.07348960
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.00011651
44Tryptophan metabolism_Homo sapiens_hsa003800.98593004
45Ether lipid metabolism_Homo sapiens_hsa005650.90715281
46Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.90059110
47Pancreatic secretion_Homo sapiens_hsa049720.85775292
48Type I diabetes mellitus_Homo sapiens_hsa049400.84118833
49Phenylalanine metabolism_Homo sapiens_hsa003600.75384264
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74762790
51Other glycan degradation_Homo sapiens_hsa005110.69654163
52Leishmaniasis_Homo sapiens_hsa051400.69214496
53Glutathione metabolism_Homo sapiens_hsa004800.68798126
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68699844
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67321048
56Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.63911991
57Glycerophospholipid metabolism_Homo sapiens_hsa005640.63756791
58Antigen processing and presentation_Homo sapiens_hsa046120.60680245
59Sphingolipid metabolism_Homo sapiens_hsa006000.58183113
60Nitrogen metabolism_Homo sapiens_hsa009100.54981651
61Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46648762
62Renin secretion_Homo sapiens_hsa049240.43327562
63Fatty acid metabolism_Homo sapiens_hsa012120.42143477
64Peroxisome_Homo sapiens_hsa041460.41371544
65Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.39541084
66Viral myocarditis_Homo sapiens_hsa054160.39469520
67Pentose phosphate pathway_Homo sapiens_hsa000300.37973636
68Insulin resistance_Homo sapiens_hsa049310.37342087
69Hepatitis C_Homo sapiens_hsa051600.37178407
70Folate biosynthesis_Homo sapiens_hsa007900.37004956
71Sulfur relay system_Homo sapiens_hsa041220.36189819
72Leukocyte transendothelial migration_Homo sapiens_hsa046700.35395660
73Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.33815089
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.33665571
75Pertussis_Homo sapiens_hsa051330.32025419
76Tyrosine metabolism_Homo sapiens_hsa003500.30731153
77Thyroid hormone synthesis_Homo sapiens_hsa049180.28821623
78Toxoplasmosis_Homo sapiens_hsa051450.28636654
79Tuberculosis_Homo sapiens_hsa051520.25737285
80Hematopoietic cell lineage_Homo sapiens_hsa046400.24887000
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.24506685
82Fatty acid biosynthesis_Homo sapiens_hsa000610.22216969
83Chemokine signaling pathway_Homo sapiens_hsa040620.21091477
84Influenza A_Homo sapiens_hsa051640.20905389
85ABC transporters_Homo sapiens_hsa020100.20710907
86Primary bile acid biosynthesis_Homo sapiens_hsa001200.20385126
87African trypanosomiasis_Homo sapiens_hsa051430.19563824
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.17566762
89Tight junction_Homo sapiens_hsa045300.14532831
90Cocaine addiction_Homo sapiens_hsa050300.13996573
91Carbon metabolism_Homo sapiens_hsa012000.13990346
92Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.12560886
93GnRH signaling pathway_Homo sapiens_hsa049120.12524205
94Metabolic pathways_Homo sapiens_hsa011000.11301701
95Glucagon signaling pathway_Homo sapiens_hsa049220.08996575
96TNF signaling pathway_Homo sapiens_hsa046680.08975472
97Biosynthesis of amino acids_Homo sapiens_hsa012300.08419739
98Insulin secretion_Homo sapiens_hsa049110.07747901
99Salmonella infection_Homo sapiens_hsa051320.05217571
100Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.04218778

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »