BTNL8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1angiotensin maturation (GO:0002003)8.04520648
2regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)6.27977049
3regulation of guanylate cyclase activity (GO:0031282)5.60993051
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.30227661
5antigen processing and presentation of endogenous antigen (GO:0019883)5.10321280
6lipoprotein transport (GO:0042953)5.08544440
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.06799038
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.01729781
9regulation of cellular extravasation (GO:0002691)4.82789546
10intestinal absorption (GO:0050892)4.74010710
11epoxygenase P450 pathway (GO:0019373)4.72106543
12fat-soluble vitamin biosynthetic process (GO:0042362)4.56272125
13NADH metabolic process (GO:0006734)4.50433451
14hormone catabolic process (GO:0042447)4.35910989
15negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.17262780
16negative regulation of cell killing (GO:0031342)4.17262780
17maintenance of gastrointestinal epithelium (GO:0030277)4.12927646
18positive regulation of guanylate cyclase activity (GO:0031284)4.09699456
19regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.99184148
20endocrine process (GO:0050886)3.99184148
21regulation of systemic arterial blood pressure by hormone (GO:0001990)3.99184148
22detection of other organism (GO:0098543)3.93009512
23regulation of bile acid biosynthetic process (GO:0070857)3.92362029
24fructose metabolic process (GO:0006000)3.87684535
25regulation of triglyceride catabolic process (GO:0010896)3.84454767
26diacylglycerol metabolic process (GO:0046339)3.84382498
27detection of bacterium (GO:0016045)3.83023951
28modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.78912232
29positive regulation by organism of defense response of other organism involved in symbiotic interact3.78912232
30modulation by symbiont of host immune response (GO:0052553)3.78912232
31positive regulation by symbiont of host defense response (GO:0052509)3.78912232
32modulation by symbiont of host defense response (GO:0052031)3.78912232
33modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.78912232
34regulation of systemic arterial blood pressure (GO:0003073)3.56143541
35bile acid and bile salt transport (GO:0015721)3.53290084
36cellular glucuronidation (GO:0052695)3.50925824
37peptide catabolic process (GO:0043171)3.50196476
38drug metabolic process (GO:0017144)3.47103229
39receptor guanylyl cyclase signaling pathway (GO:0007168)3.45837756
40glucuronate metabolic process (GO:0019585)3.40644559
41uronic acid metabolic process (GO:0006063)3.40644559
42leukotriene metabolic process (GO:0006691)3.33836498
43alkaloid metabolic process (GO:0009820)3.28757037
44positive regulation of Cdc42 GTPase activity (GO:0043089)3.27519513
45regulation of cGMP biosynthetic process (GO:0030826)3.25481195
46detection of external biotic stimulus (GO:0098581)3.19798018
47regulation of interferon-beta biosynthetic process (GO:0045357)3.19793289
48macrophage activation involved in immune response (GO:0002281)3.19573172
49very-low-density lipoprotein particle assembly (GO:0034379)3.18929996
50immunoglobulin mediated immune response (GO:0016064)3.18092811
51antimicrobial humoral response (GO:0019730)3.16560485
52antibacterial humoral response (GO:0019731)3.15207486
53dendritic cell chemotaxis (GO:0002407)3.13450067
54peptide hormone processing (GO:0016486)3.12918423
55positive regulation of gamma-delta T cell activation (GO:0046645)3.12695932
56regulation of dendritic cell antigen processing and presentation (GO:0002604)3.10300298
57plasma lipoprotein particle assembly (GO:0034377)3.09467347
58renal system process involved in regulation of blood volume (GO:0001977)3.08285320
59neutrophil activation involved in immune response (GO:0002283)3.08280669
60positive regulation of pseudopodium assembly (GO:0031274)3.07640803
61regulation of vitamin metabolic process (GO:0030656)3.07454410
62cytidine deamination (GO:0009972)3.07114790
63cytidine metabolic process (GO:0046087)3.07114790
64cytidine catabolic process (GO:0006216)3.07114790
65glycosphingolipid catabolic process (GO:0046479)3.06636328
66urea cycle (GO:0000050)3.05510324
67virion attachment to host cell (GO:0019062)3.01824374
68adhesion of symbiont to host cell (GO:0044650)3.01824374
69glycolipid catabolic process (GO:0019377)3.00991615
70epithelial structure maintenance (GO:0010669)3.00343744
71flavonoid metabolic process (GO:0009812)2.99307812
72dendritic cell migration (GO:0036336)2.93815155
73urea metabolic process (GO:0019627)2.93551620
74citrulline biosynthetic process (GO:0019240)2.89311558
75pyrimidine ribonucleoside catabolic process (GO:0046133)2.89095746
76digestion (GO:0007586)2.85086628
77phospholipid efflux (GO:0033700)2.82076736
78protein-lipid complex assembly (GO:0065005)2.77817566
79regulation of pseudopodium assembly (GO:0031272)2.72571570
80nitrogen cycle metabolic process (GO:0071941)2.72033305
81positive regulation of respiratory burst (GO:0060267)2.71869355
82respiratory burst (GO:0045730)2.71513478
83cGMP-mediated signaling (GO:0019934)2.70422712
84neutrophil activation (GO:0042119)2.70181790
85detection of biotic stimulus (GO:0009595)2.68462287
86cellular response to reactive nitrogen species (GO:1902170)2.67581105
87phospholipid scrambling (GO:0017121)2.66983475
88positive regulation of lipid catabolic process (GO:0050996)2.65541705
89digestive system process (GO:0022600)2.65492229
90detection of molecule of bacterial origin (GO:0032490)2.63328533
91regulation of cGMP metabolic process (GO:0030823)2.60190439
92antigen processing and presentation via MHC class Ib (GO:0002475)2.58953957
93fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.58310531
94drug transport (GO:0015893)2.58270930
95thrombin receptor signaling pathway (GO:0070493)2.56997674
96regulation of B cell receptor signaling pathway (GO:0050855)2.56907257
97regulation of gamma-delta T cell activation (GO:0046643)2.56800485
98positive regulation of lipoprotein lipase activity (GO:0051006)2.56384105
99positive regulation of triglyceride lipase activity (GO:0061365)2.56384105
100positive regulation of antigen processing and presentation (GO:0002579)2.53305364

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.58328386
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.44024167
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.24754664
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.23265789
5CDX2_20551321_ChIP-Seq_CACO-2_Human3.21828534
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.56862064
7GATA1_22025678_ChIP-Seq_K562_Human2.29333969
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.27264090
9RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.19970757
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.19518485
11IRF8_27001747_Chip-Seq_BMDM_Mouse2.18374210
12SOX2_27498859_Chip-Seq_STOMACH_Mouse2.11631094
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.10234569
14RXR_22158963_ChIP-Seq_LIVER_Mouse1.98424700
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.96562611
16PPARA_22158963_ChIP-Seq_LIVER_Mouse1.94966787
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.94850733
18GATA4_25053715_ChIP-Seq_YYC3_Human1.90677919
19VDR_24763502_ChIP-Seq_THP-1_Human1.90390378
20CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.84005081
21LXR_22158963_ChIP-Seq_LIVER_Mouse1.83194828
22VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.78294372
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.75528067
24STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.73176988
25EGR1_23403033_ChIP-Seq_LIVER_Mouse1.71198180
26MYB_21317192_ChIP-Seq_ERMYB_Mouse1.65912438
27SPI1_23127762_ChIP-Seq_K562_Human1.64509522
28CDX2_19796622_ChIP-Seq_MESCs_Mouse1.61961993
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.60934658
30VDR_21846776_ChIP-Seq_THP-1_Human1.60155074
31GATA6_25053715_ChIP-Seq_YYC3_Human1.59784543
32RUNX_20019798_ChIP-Seq_JUKART_Human1.57636147
33VDR_24787735_ChIP-Seq_THP-1_Human1.54981342
34Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.53929739
35* SPI1_23547873_ChIP-Seq_NB4_Human1.53791006
36* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.53627645
37IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.52297909
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.52210389
39LXR_22292898_ChIP-Seq_THP-1_Human1.50018882
40SOX2_20726797_ChIP-Seq_SW620_Human1.49869503
41FOXO3_23340844_ChIP-Seq_DLD1_Human1.48129122
42FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.43860419
43* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.43081499
44NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.42496439
45RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.42455971
46CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.38833124
47CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.38701869
48PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.37377325
49RUNX1_22412390_ChIP-Seq_EML_Mouse1.36902479
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.36218637
51GATA2_22383799_ChIP-Seq_G1ME_Mouse1.35135327
52MYB_26560356_Chip-Seq_TH2_Human1.34223614
53STAT4_19710469_ChIP-ChIP_TH1__Mouse1.30074253
54GATA2_19941826_ChIP-Seq_K562_Human1.30012048
55* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.29604689
56PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.29208092
57FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.26756403
58GATA1_19941826_ChIP-Seq_K562_Human1.26286900
59MYB_26560356_Chip-Seq_TH1_Human1.24864067
60BCL6_27268052_Chip-Seq_Bcells_Human1.24501712
61BRD4_27068464_Chip-Seq_AML-cells_Mouse1.23416022
62GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.19614351
63GATA1_19941827_ChIP-Seq_MEL_Mouse1.19037677
64BCOR_27268052_Chip-Seq_Bcells_Human1.17779192
65MAF_26560356_Chip-Seq_TH1_Human1.17454679
66UTX_26944678_Chip-Seq_JUKART_Human1.17398363
67NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.16828945
68TCF7_22412390_ChIP-Seq_EML_Mouse1.12992050
69GATA1_22383799_ChIP-Seq_G1ME_Mouse1.12617057
70KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11908137
71MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.08129514
72PPAR_26484153_Chip-Seq_NCI-H1993_Human1.07887719
73SCL_19346495_ChIP-Seq_HPC-7_Human1.07674257
74RACK7_27058665_Chip-Seq_MCF-7_Human1.07484859
75LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.07392948
76GATA2_21666600_ChIP-Seq_HMVEC_Human1.06783405
77AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.05988639
78BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.05987999
79EGR1_19032775_ChIP-ChIP_M12_Human1.03557758
80ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.02427538
81KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02332321
82PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00917608
83SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.00840136
84SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.00095366
85SA1_27219007_Chip-Seq_Bcells_Human0.98474529
86CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96110988
87IKZF1_21737484_ChIP-ChIP_HCT116_Human0.93604202
88GATA3_27048872_Chip-Seq_THYMUS_Human0.93203185
89* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92233037
90LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.88586765
91TCF4_18268006_ChIP-ChIP_LS174T_Human0.88338294
92SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88237788
93TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87550410
94NANOG_20526341_ChIP-Seq_ESCs_Human0.86761583
95ELK3_25401928_ChIP-Seq_HUVEC_Human0.86458722
96KLF5_25053715_ChIP-Seq_YYC3_Human0.85638361
97* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.85551185
98DROSHA_22980978_ChIP-Seq_HELA_Human0.84595585
99KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.83597165
100CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.83530872

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.51821316
2MP0003183_abnormal_peptide_metabolism3.98348150
3MP0005085_abnormal_gallbladder_physiolo3.86379670
4MP0003724_increased_susceptibility_to3.41602082
5MP0001666_abnormal_nutrient_absorption3.31137537
6MP0002139_abnormal_hepatobiliary_system3.12538362
7MP0010155_abnormal_intestine_physiology3.02712510
8MP0005365_abnormal_bile_salt2.72285553
9MP0003866_abnormal_defecation2.63729220
10MP0004264_abnormal_extraembryonic_tissu2.61522794
11MP0004019_abnormal_vitamin_homeostasis2.61395345
12MP0009840_abnormal_foam_cell2.60915717
13MP0003436_decreased_susceptibility_to2.51910341
14MP0004147_increased_porphyrin_level2.35328044
15MP0003303_peritoneal_inflammation2.26528482
16MP0001835_abnormal_antigen_presentation2.19066036
17MP0009379_abnormal_foot_pigmentation2.17427743
18MP0010234_abnormal_vibrissa_follicle2.12986519
19MP0009785_altered_susceptibility_to2.02970915
20MP0005025_abnormal_response_to1.90355313
21MP0003191_abnormal_cellular_cholesterol1.89741710
22MP0000490_abnormal_crypts_of1.80544264
23MP0002419_abnormal_innate_immunity1.70049051
24MP0005387_immune_system_phenotype1.68561140
25MP0001790_abnormal_immune_system1.68561140
26MP0001664_abnormal_digestion1.67928352
27MP0005166_decreased_susceptibility_to1.67897067
28MP0001800_abnormal_humoral_immune1.65980997
29MP0005409_darkened_coat_color1.64927029
30MP0003300_gastrointestinal_ulcer1.60657035
31MP0005671_abnormal_response_to1.57288208
32MP0003252_abnormal_bile_duct1.54253158
33MP0006082_CNS_inflammation1.53924251
34MP0010329_abnormal_lipoprotein_level1.53419491
35MP0001845_abnormal_inflammatory_respons1.53074875
36MP0005451_abnormal_body_composition1.52326064
37MP0000465_gastrointestinal_hemorrhage1.50437511
38MP0001663_abnormal_digestive_system1.48825833
39MP0005000_abnormal_immune_tolerance1.47203673
40MP0002723_abnormal_immune_serum1.42718295
41MP0000685_abnormal_immune_system1.42165291
42MP0002396_abnormal_hematopoietic_system1.41875855
43MP0009643_abnormal_urine_homeostasis1.40406366
44MP0002148_abnormal_hypersensitivity_rea1.38639364
45MP0001873_stomach_inflammation1.37611299
46MP0001765_abnormal_ion_homeostasis1.37500795
47MP0008260_abnormal_autophagy1.35340662
48MP0001819_abnormal_immune_cell1.35005844
49MP0001533_abnormal_skeleton_physiology1.34521345
50MP0002452_abnormal_antigen_presenting1.34425503
51MP0002420_abnormal_adaptive_immunity1.34191690
52MP0003868_abnormal_feces_composition1.32070067
53MP0003806_abnormal_nucleotide_metabolis1.29597708
54MP0000477_abnormal_intestine_morphology1.28052188
55MP0010352_gastrointestinal_tract_polyps1.26852989
56MP0008469_abnormal_protein_level1.25691617
57MP0005332_abnormal_amino_acid1.21840397
58MP0004858_abnormal_nervous_system1.21179110
59MP0000678_abnormal_parathyroid_gland1.20121273
60MP0009764_decreased_sensitivity_to1.19846662
61MP0001764_abnormal_homeostasis1.17086818
62MP0005381_digestive/alimentary_phenotyp1.12141774
63MP0002277_abnormal_respiratory_mucosa1.12118227
64MP0004947_skin_inflammation1.12056234
65MP0002138_abnormal_hepatobiliary_system1.08822690
66MP0005636_abnormal_mineral_homeostasis1.06438655
67MP0002136_abnormal_kidney_physiology1.06048007
68MP0009333_abnormal_splenocyte_physiolog1.03669565
69MP0002166_altered_tumor_susceptibility1.03101489
70MP0002118_abnormal_lipid_homeostasis1.01497455
71MP0000609_abnormal_liver_physiology1.01111849
72MP0002132_abnormal_respiratory_system1.00814773
73MP0004043_abnormal_pH_regulation0.96281328
74MP0000716_abnormal_immune_system0.95713768
75MP0003879_abnormal_hair_cell0.94664636
76MP0005464_abnormal_platelet_physiology0.92636924
77MP0003763_abnormal_thymus_physiology0.92092663
78MP0005310_abnormal_salivary_gland0.92073369
79MP0005319_abnormal_enzyme/_coenzyme0.92009554
80MP0005535_abnormal_body_temperature0.89063815
81MP0005670_abnormal_white_adipose0.86289949
82MP0005584_abnormal_enzyme/coenzyme_acti0.85567510
83MP0000538_abnormal_urinary_bladder0.84535052
84MP0002971_abnormal_brown_adipose0.83871077
85MP0002876_abnormal_thyroid_physiology0.81372386
86MP0000015_abnormal_ear_pigmentation0.77395731
87MP0001188_hyperpigmentation0.77256334
88MP0000249_abnormal_blood_vessel0.76300916
89MP0005448_abnormal_energy_balance0.76182624
90MP0002398_abnormal_bone_marrow0.76168529
91MP0002998_abnormal_bone_remodeling0.75627813
92MP0009115_abnormal_fat_cell0.74897156
93MP0000604_amyloidosis0.74848592
94MP0003075_altered_response_to0.74625440
95MP0002405_respiratory_system_inflammati0.73602603
96MP0001501_abnormal_sleep_pattern0.72437193
97MP0002429_abnormal_blood_cell0.70984323
98MP0009642_abnormal_blood_homeostasis0.70295606
99MP0000858_altered_metastatic_potential0.70074023
100MP0000230_abnormal_systemic_arterial0.69971909

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glutamine family amino acid metabolism (HP:0010902)7.46688649
2Malnutrition (HP:0004395)5.84095677
3Eczematoid dermatitis (HP:0000976)5.52838458
4Hydroxyprolinuria (HP:0003080)5.12084321
5Abnormality of proline metabolism (HP:0010907)5.12084321
6Chronic diarrhea (HP:0002028)4.59542217
7Hypobetalipoproteinemia (HP:0003563)3.84098165
8Widely patent fontanelles and sutures (HP:0004492)3.74301032
9Orchitis (HP:0100796)3.74154537
10Abnormality of the vitamin B12 metabolism (HP:0004341)3.71781393
11Myositis (HP:0100614)3.64798947
12Systemic lupus erythematosus (HP:0002725)3.62854603
13Ileus (HP:0002595)3.58605361
14Recurrent abscess formation (HP:0002722)3.57168636
15Recurrent bacterial skin infections (HP:0005406)3.47444739
16Abnormality of vitamin B metabolism (HP:0004340)3.46279569
17Acanthocytosis (HP:0001927)3.45947022
18Hyperactive renin-angiotensin system (HP:0000841)3.42004887
19Gingivitis (HP:0000230)3.40345119
20Abnormality of macrophages (HP:0004311)3.38235992
21Fat malabsorption (HP:0002630)3.29158424
22Metabolic alkalosis (HP:0200114)3.19966735
23Decreased circulating renin level (HP:0003351)3.18562226
24Gastrointestinal infarctions (HP:0005244)3.07208541
25Retrobulbar optic neuritis (HP:0100654)3.04181078
26Optic neuritis (HP:0100653)3.04181078
27Recurrent gram-negative bacterial infections (HP:0005420)3.03773080
28Elevated erythrocyte sedimentation rate (HP:0003565)2.96943347
29Encephalitis (HP:0002383)2.95210865
30Confusion (HP:0001289)2.90513898
31Pigmentary retinal degeneration (HP:0001146)2.82527374
32Alkalosis (HP:0001948)2.73154950
33Thin bony cortex (HP:0002753)2.72232267
34Abnormality of vitamin metabolism (HP:0100508)2.71366491
35Vasculitis (HP:0002633)2.69965946
36Abnormal delayed hypersensitivity skin test (HP:0002963)2.68205297
37Abnormality of renin-angiotensin system (HP:0000847)2.65554975
38Nausea (HP:0002018)2.65536121
39Chronic obstructive pulmonary disease (HP:0006510)2.63654843
40Obstructive lung disease (HP:0006536)2.63654843
41Abnormality of monocarboxylic acid metabolism (HP:0010996)2.62600866
42Hemorrhage of the eye (HP:0011885)2.61628772
43Meningitis (HP:0001287)2.57648891
44Recurrent fungal infections (HP:0002841)2.56785492
45Petechiae (HP:0000967)2.52783578
46Spontaneous hematomas (HP:0007420)2.52553326
47Wide cranial sutures (HP:0010537)2.50736223
48Congenital sensorineural hearing impairment (HP:0008527)2.50252814
49Abdominal distention (HP:0003270)2.48553743
50Urticaria (HP:0001025)2.38607056
51Amyloidosis (HP:0011034)2.36159892
52Hypophosphatemia (HP:0002148)2.34520817
53Stomatitis (HP:0010280)2.33266305
54Hyperglycinuria (HP:0003108)2.32202840
55Glycosuria (HP:0003076)2.29612540
56Abnormality of urine glucose concentration (HP:0011016)2.29612540
57Mediastinal lymphadenopathy (HP:0100721)2.28656216
58Recurrent skin infections (HP:0001581)2.27069356
59Keratoconjunctivitis sicca (HP:0001097)2.26965409
60Hemoptysis (HP:0002105)2.23032289
61Segmental peripheral demyelination/remyelination (HP:0003481)2.22849156
62Xanthomatosis (HP:0000991)2.22739650
63Proximal tubulopathy (HP:0000114)2.20754559
64Inflammation of the large intestine (HP:0002037)2.20504351
65Increased IgE level (HP:0003212)2.18799164
66Pustule (HP:0200039)2.18392298
67Chest pain (HP:0100749)2.12268409
68Cellulitis (HP:0100658)2.11718601
69Nephrolithiasis (HP:0000787)2.10748738
70Gastrointestinal inflammation (HP:0004386)2.09274946
71Glomerulonephritis (HP:0000099)2.09165732
72Osteomyelitis (HP:0002754)2.08845838
73Keratoconjunctivitis (HP:0001096)2.08735497
74Pulmonary infiltrates (HP:0002113)2.07626625
75Skin rash (HP:0000988)2.06826836
76Pancreatitis (HP:0001733)2.05564632
77Villous atrophy (HP:0011473)2.04702793
78Abnormality of small intestinal villus morphology (HP:0011472)2.04702793
79Peritonitis (HP:0002586)2.02412555
80Premature loss of primary teeth (HP:0006323)2.01000552
81Steatorrhea (HP:0002570)2.00881764
82Gingival bleeding (HP:0000225)1.97319993
83Abnormality of the costochondral junction (HP:0000919)1.97058217
84Paresthesia (HP:0003401)1.95812232
85Abnormality of glycine metabolism (HP:0010895)1.95254132
86Abnormality of serine family amino acid metabolism (HP:0010894)1.95254132
87Potter facies (HP:0002009)1.95215736
88Facial shape deformation (HP:0011334)1.95215736
89Hyperparathyroidism (HP:0000843)1.92804336
90Flat acetabular roof (HP:0003180)1.90881175
91Hypochromic anemia (HP:0001931)1.90244530
92Chronic mucocutaneous candidiasis (HP:0002728)1.89461805
93Recurrent cutaneous fungal infections (HP:0011370)1.89461805
94Hypotension (HP:0002615)1.87972468
95Posterior subcapsular cataract (HP:0007787)1.87259140
96Abnormality of complement system (HP:0005339)1.85454776
97Enlarged epiphyses (HP:0010580)1.85019051
98Gastrointestinal dysmotility (HP:0002579)1.84781271
99Hyperammonemia (HP:0001987)1.83881819
100Hypolipoproteinemia (HP:0010981)1.83132090

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B5.31915120
2ERN14.49337448
3RIPK43.83699155
4MAP4K12.79977881
5TYK22.67183014
6PRKG22.46262011
7IRAK42.43151035
8MST1R2.42622286
9EPHB12.35997819
10GRK62.32434387
11RIPK12.30038817
12CSK1.98562696
13BLK1.83220209
14TESK21.72886190
15PTK61.70313851
16MAP2K31.65804659
17TAOK11.65284161
18MAP3K101.62815657
19MAP3K21.60642824
20PRPF4B1.55656943
21MAP3K111.52000019
22EPHA31.49839483
23MAP3K11.46393651
24ZAP701.44426542
25MAP3K31.35192623
26FGFR41.33255716
27MATK1.29032867
28JAK31.26224180
29BTK1.23952629
30OXSR11.23225152
31FES1.22993071
32YES11.20293006
33TXK1.19744843
34IRAK11.19458017
35EPHA21.18434251
36PIK3CA1.17853956
37JAK21.17752384
38TNK21.17474899
39KSR21.16126461
40IKBKE1.14528914
41SYK1.12632423
42HCK1.07068849
43TBK11.05355281
44FGR1.02297442
45LYN1.01497008
46PDPK10.99019309
47JAK10.98471340
48MAP3K140.98367811
49FGFR30.97735142
50MAP3K120.93933203
51NLK0.93804892
52PDK10.91166921
53BMPR20.87557468
54CDK190.86398230
55SIK30.85702227
56CSF1R0.82200619
57MAP2K60.81408328
58DYRK1B0.78909393
59TAOK30.78520833
60LCK0.77971797
61MAP2K20.74963616
62STK390.73693234
63ITK0.72943078
64KIT0.72298559
65CDC42BPA0.70448532
66FYN0.68995269
67STK240.62667377
68PRKCZ0.62072271
69TEC0.60152453
70PDK20.59994194
71PIM10.59555535
72MAP3K60.57081992
73PRKAA20.56955570
74IRAK20.54969089
75RET0.54501044
76DAPK20.54024846
77PIK3CG0.53406257
78PRKD20.53208377
79ERBB20.52828695
80LRRK20.52554625
81SMG10.48826209
82PRKCQ0.44961362
83PRKACG0.42401543
84STK110.42079985
85LMTK20.41752720
86MAP3K50.41631191
87TRIB30.40529764
88PRKCD0.40291764
89MAP2K40.40141535
90MAPK110.39363782
91MAP3K70.38866246
92TNIK0.38655314
93MAPKAPK20.38366651
94MET0.37995579
95TGFBR20.34376175
96EPHB20.31778508
97MARK20.30723912
98TAOK20.30185876
99SRC0.29917840
100AKT30.29001168

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004604.23970225
2Vitamin digestion and absorption_Homo sapiens_hsa049773.59903801
3Fat digestion and absorption_Homo sapiens_hsa049753.51549415
4Renin-angiotensin system_Homo sapiens_hsa046143.45234644
5Mineral absorption_Homo sapiens_hsa049782.29881504
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.11501540
7Starch and sucrose metabolism_Homo sapiens_hsa005002.09746372
8Carbohydrate digestion and absorption_Homo sapiens_hsa049732.03880284
9Caffeine metabolism_Homo sapiens_hsa002321.99480033
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.93629442
11Protein digestion and absorption_Homo sapiens_hsa049741.91226624
12Staphylococcus aureus infection_Homo sapiens_hsa051501.89917110
13Histidine metabolism_Homo sapiens_hsa003401.88255398
14Drug metabolism - other enzymes_Homo sapiens_hsa009831.79123409
15Pentose and glucuronate interconversions_Homo sapiens_hsa000401.75651497
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.73593415
17Arginine biosynthesis_Homo sapiens_hsa002201.68014565
18Fructose and mannose metabolism_Homo sapiens_hsa000511.66007235
19Galactose metabolism_Homo sapiens_hsa000521.64903272
20Leishmaniasis_Homo sapiens_hsa051401.56669052
21Retinol metabolism_Homo sapiens_hsa008301.53987142
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.53189566
23Chemical carcinogenesis_Homo sapiens_hsa052041.52530697
24Allograft rejection_Homo sapiens_hsa053301.52481168
25Sulfur metabolism_Homo sapiens_hsa009201.50551707
26Linoleic acid metabolism_Homo sapiens_hsa005911.50145924
27PPAR signaling pathway_Homo sapiens_hsa033201.48531166
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.48277173
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.47813889
30Graft-versus-host disease_Homo sapiens_hsa053321.47437851
31Autoimmune thyroid disease_Homo sapiens_hsa053201.41959272
32Bile secretion_Homo sapiens_hsa049761.40496054
33Arachidonic acid metabolism_Homo sapiens_hsa005901.29544312
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.28150032
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.25194205
36Asthma_Homo sapiens_hsa053101.19581932
37Glycerolipid metabolism_Homo sapiens_hsa005611.17795092
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.11807549
39Osteoclast differentiation_Homo sapiens_hsa043801.07442208
40Type I diabetes mellitus_Homo sapiens_hsa049401.06029029
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.05080030
42Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.04323756
43Tuberculosis_Homo sapiens_hsa051520.96403975
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.87550101
45Antigen processing and presentation_Homo sapiens_hsa046120.85943773
46Fatty acid degradation_Homo sapiens_hsa000710.85571376
47Maturity onset diabetes of the young_Homo sapiens_hsa049500.84932653
48Ether lipid metabolism_Homo sapiens_hsa005650.78890392
49Glycerophospholipid metabolism_Homo sapiens_hsa005640.77000483
50Chemokine signaling pathway_Homo sapiens_hsa040620.76818021
51Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.76341627
52Leukocyte transendothelial migration_Homo sapiens_hsa046700.73302637
53Hematopoietic cell lineage_Homo sapiens_hsa046400.71515763
54B cell receptor signaling pathway_Homo sapiens_hsa046620.70528586
55Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.68581335
56Hepatitis C_Homo sapiens_hsa051600.67350458
57Pancreatic secretion_Homo sapiens_hsa049720.67183103
58African trypanosomiasis_Homo sapiens_hsa051430.67126836
59Toxoplasmosis_Homo sapiens_hsa051450.66904261
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66802509
61Arginine and proline metabolism_Homo sapiens_hsa003300.66109397
62Tryptophan metabolism_Homo sapiens_hsa003800.64695939
63Other glycan degradation_Homo sapiens_hsa005110.62808543
64Viral myocarditis_Homo sapiens_hsa054160.62445692
65Influenza A_Homo sapiens_hsa051640.61969505
66Adipocytokine signaling pathway_Homo sapiens_hsa049200.58829789
67Primary immunodeficiency_Homo sapiens_hsa053400.55973900
68Toll-like receptor signaling pathway_Homo sapiens_hsa046200.54908381
69Pertussis_Homo sapiens_hsa051330.54305361
70Insulin resistance_Homo sapiens_hsa049310.53762035
71NF-kappa B signaling pathway_Homo sapiens_hsa040640.50466193
72Phenylalanine metabolism_Homo sapiens_hsa003600.50424378
73NOD-like receptor signaling pathway_Homo sapiens_hsa046210.49978306
74TNF signaling pathway_Homo sapiens_hsa046680.46689523
75Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46281317
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45993772
77Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45737935
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.44989403
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44342165
80Sphingolipid metabolism_Homo sapiens_hsa006000.43611519
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42875257
82Phagosome_Homo sapiens_hsa041450.42344244
83Nitrogen metabolism_Homo sapiens_hsa009100.40913961
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38731185
85Herpes simplex infection_Homo sapiens_hsa051680.37945232
86Measles_Homo sapiens_hsa051620.35187916
87Renin secretion_Homo sapiens_hsa049240.35067289
88Acute myeloid leukemia_Homo sapiens_hsa052210.34976010
89Salmonella infection_Homo sapiens_hsa051320.34676853
90Fatty acid biosynthesis_Homo sapiens_hsa000610.32267406
91Glutathione metabolism_Homo sapiens_hsa004800.29601261
92Jak-STAT signaling pathway_Homo sapiens_hsa046300.29516355
93T cell receptor signaling pathway_Homo sapiens_hsa046600.29356911
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.27489330
95GnRH signaling pathway_Homo sapiens_hsa049120.27269805
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.26809240
97Malaria_Homo sapiens_hsa051440.26536319
98ABC transporters_Homo sapiens_hsa020100.26035362
99Platelet activation_Homo sapiens_hsa046110.25497712
100Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.24067876

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