BUB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a serine/threonine-protein kinase that play a central role in mitosis. The encoded protein functions in part by phosphorylating members of the mitotic checkpoint complex and activating the spindle checkpoint. This protein also plays a role in inhibiting the activation of the anaphase promoting complex/cyclosome. This protein may also function in the DNA damage response. Mutations in this gene have been associated with aneuploidy and several forms of cancer. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.53720698
2nuclear pore organization (GO:0006999)5.26565084
3nuclear pore complex assembly (GO:0051292)5.13864102
4DNA unwinding involved in DNA replication (GO:0006268)5.04860295
5kinetochore organization (GO:0051383)4.98770675
6mitotic metaphase plate congression (GO:0007080)4.96491701
7mitotic chromosome condensation (GO:0007076)4.92531194
8protein localization to chromosome, centromeric region (GO:0071459)4.81205737
9mitotic sister chromatid segregation (GO:0000070)4.79939632
10sister chromatid segregation (GO:0000819)4.67755655
11DNA ligation (GO:0006266)4.61283379
12synapsis (GO:0007129)4.61176873
13establishment of integrated proviral latency (GO:0075713)4.52700526
14metaphase plate congression (GO:0051310)4.51836040
15attachment of spindle microtubules to kinetochore (GO:0008608)4.48320509
16chromatin remodeling at centromere (GO:0031055)4.48067803
17DNA replication-dependent nucleosome assembly (GO:0006335)4.46041076
18DNA replication-dependent nucleosome organization (GO:0034723)4.46041076
19DNA replication initiation (GO:0006270)4.44823197
20mitotic nuclear envelope disassembly (GO:0007077)4.44644227
21CENP-A containing nucleosome assembly (GO:0034080)4.44510294
22DNA strand elongation involved in DNA replication (GO:0006271)4.38827806
23regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.33975303
24regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.33742854
25regulation of spindle organization (GO:0090224)4.30132418
26mitotic sister chromatid cohesion (GO:0007064)4.26639979
27kinetochore assembly (GO:0051382)4.22014782
28DNA strand elongation (GO:0022616)4.17012758
29membrane disassembly (GO:0030397)4.15626000
30nuclear envelope disassembly (GO:0051081)4.15626000
31DNA synthesis involved in DNA repair (GO:0000731)4.15048152
32establishment of chromosome localization (GO:0051303)4.14713285
33DNA replication-independent nucleosome organization (GO:0034724)4.13731153
34DNA replication-independent nucleosome assembly (GO:0006336)4.13731153
35meiotic chromosome segregation (GO:0045132)4.06714522
36telomere maintenance via semi-conservative replication (GO:0032201)4.02787832
37histone exchange (GO:0043486)3.97875434
38pore complex assembly (GO:0046931)3.94181848
39DNA replication checkpoint (GO:0000076)3.93701722
40regulation of mitotic spindle organization (GO:0060236)3.88990730
41mitotic recombination (GO:0006312)3.87288886
42positive regulation of chromosome segregation (GO:0051984)3.86498094
43telomere maintenance via recombination (GO:0000722)3.78277948
44* regulation of chromosome segregation (GO:0051983)3.75687741
45positive regulation of mitotic sister chromatid separation (GO:1901970)3.70131870
46positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.70131870
47positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.70131870
48protein localization to chromosome (GO:0034502)3.68598900
49DNA geometric change (GO:0032392)3.67231413
50regulation of centriole replication (GO:0046599)3.67076269
51regulation of centrosome cycle (GO:0046605)3.66787695
52DNA duplex unwinding (GO:0032508)3.66417321
53* spindle checkpoint (GO:0031577)3.65244127
54chromosome organization involved in meiosis (GO:0070192)3.62302043
55chromatin assembly or disassembly (GO:0006333)3.61247801
56regulation of histone H3-K9 methylation (GO:0051570)3.57288356
57nucleobase biosynthetic process (GO:0046112)3.55301257
58IMP biosynthetic process (GO:0006188)3.53616448
59non-recombinational repair (GO:0000726)3.52085962
60double-strand break repair via nonhomologous end joining (GO:0006303)3.52085962
61* chromosome segregation (GO:0007059)3.51616570
62* negative regulation of chromosome segregation (GO:0051985)3.50381885
63* regulation of mitotic metaphase/anaphase transition (GO:0030071)3.50040212
64regulation of DNA endoreduplication (GO:0032875)3.49986578
65heterochromatin organization (GO:0070828)3.49535511
66folic acid-containing compound biosynthetic process (GO:0009396)3.48397740
67protein K6-linked ubiquitination (GO:0085020)3.47225601
68* spindle assembly checkpoint (GO:0071173)3.46160950
69chromosome condensation (GO:0030261)3.45333318
70* negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.45084252
71* negative regulation of sister chromatid segregation (GO:0033046)3.45084252
72* negative regulation of mitotic sister chromatid separation (GO:2000816)3.45084252
73* negative regulation of mitotic sister chromatid segregation (GO:0033048)3.45084252
74regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.44476769
75sister chromatid cohesion (GO:0007062)3.42101210
76* regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.42079560
77* mitotic spindle checkpoint (GO:0071174)3.39014740
78telomere maintenance via telomere lengthening (GO:0010833)3.38290344
79resolution of meiotic recombination intermediates (GO:0000712)3.38122448
80establishment of viral latency (GO:0019043)3.36292631
81* mitotic spindle assembly checkpoint (GO:0007094)3.35268252
82* negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.34861461
83nucleotide-excision repair, DNA gap filling (GO:0006297)3.34584326
84pre-miRNA processing (GO:0031054)3.34539821
85* regulation of mitotic sister chromatid separation (GO:0010965)3.34339810
86* regulation of mitotic sister chromatid segregation (GO:0033047)3.34339810
87* regulation of sister chromatid segregation (GO:0033045)3.34339810
88somatic diversification of immune receptors via somatic mutation (GO:0002566)3.33179570
89somatic hypermutation of immunoglobulin genes (GO:0016446)3.33179570
90ATP-dependent chromatin remodeling (GO:0043044)3.29611105
91* negative regulation of mitosis (GO:0045839)3.28713368
92DNA conformation change (GO:0071103)3.28535954
93negative regulation of histone methylation (GO:0031061)3.26906568
94chromosome organization (GO:0051276)3.25631221
95formation of translation preinitiation complex (GO:0001731)3.25179956
96purine nucleobase biosynthetic process (GO:0009113)3.23786248
97DNA topological change (GO:0006265)3.21491646
98regulation of helicase activity (GO:0051095)3.21157248
99nuclear envelope organization (GO:0006998)3.20454344
100ribosome assembly (GO:0042255)3.20242534
101* regulation of sister chromatid cohesion (GO:0007063)3.20177875
102* mitotic cell cycle (GO:0000278)3.19516132
103protein complex localization (GO:0031503)3.18232979
104mitotic G2/M transition checkpoint (GO:0044818)3.16779914
105DNA packaging (GO:0006323)3.16085464
106anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.14310501
107IMP metabolic process (GO:0046040)3.14013402
108translesion synthesis (GO:0019985)3.11247696
109regulation of double-strand break repair via homologous recombination (GO:0010569)3.10187349
110regulation of gene silencing by RNA (GO:0060966)3.08130605
111regulation of posttranscriptional gene silencing (GO:0060147)3.08130605
112regulation of gene silencing by miRNA (GO:0060964)3.08130605
113regulation of centrosome duplication (GO:0010824)3.08061828
114postreplication repair (GO:0006301)3.07856403
115chromatin assembly (GO:0031497)3.06644098
116microtubule depolymerization (GO:0007019)3.05542193
117mitotic spindle organization (GO:0007052)3.04807298
118regulation of spindle checkpoint (GO:0090231)3.04319190
119dosage compensation (GO:0007549)3.01202776
120mismatch repair (GO:0006298)3.01119255

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.37147192
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.65020450
3* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.96773444
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.91534880
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.95221669
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.84214879
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.82808664
8AR_21909140_ChIP-Seq_LNCAP_Human2.76536051
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.63863931
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.60668711
11* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.56732739
12E2F1_21310950_ChIP-Seq_MCF-7_Human2.39183835
13* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.38847840
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.38781546
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.30885341
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.29991897
17MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.26226528
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.17225761
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.08974929
20* XRN2_22483619_ChIP-Seq_HELA_Human2.07649533
21E2F7_22180533_ChIP-Seq_HELA_Human10.5347535
22ETS1_20019798_ChIP-Seq_JURKAT_Human1.98744385
23SALL1_21062744_ChIP-ChIP_HESCs_Human1.91341294
24MYCN_18555785_ChIP-Seq_MESCs_Mouse1.90996058
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.89360709
26GABP_17652178_ChIP-ChIP_JURKAT_Human1.87719784
27VDR_23849224_ChIP-Seq_CD4+_Human1.78646133
28JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.77142725
29POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.74259271
30NANOG_18555785_ChIP-Seq_MESCs_Mouse1.73141320
31E2F1_18555785_ChIP-Seq_MESCs_Mouse1.69286231
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.66820480
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.66341676
34TTF2_22483619_ChIP-Seq_HELA_Human1.65207883
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63668853
36FOXP3_21729870_ChIP-Seq_TREG_Human1.63416433
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62612220
38SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.58720031
39DCP1A_22483619_ChIP-Seq_HELA_Human1.55049553
40ELK1_19687146_ChIP-ChIP_HELA_Human1.54120333
41TP63_19390658_ChIP-ChIP_HaCaT_Human1.52283872
42SOX2_18555785_ChIP-Seq_MESCs_Mouse1.49009958
43MYC_22102868_ChIP-Seq_BL_Human1.47853811
44* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45148548
45GABP_19822575_ChIP-Seq_HepG2_Human1.44057151
46RBPJ_22232070_ChIP-Seq_NCS_Mouse1.41834929
47KDM5A_27292631_Chip-Seq_BREAST_Human1.41244740
48CIITA_25753668_ChIP-Seq_RAJI_Human1.41076515
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.39559500
50POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.39471069
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.32643959
52FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.32585377
53POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.30231974
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.24135972
55ELF1_17652178_ChIP-ChIP_JURKAT_Human1.23257220
56STAT3_1855785_ChIP-Seq_MESCs_Mouse1.23003768
57PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22234330
58SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.21344525
59CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21194865
60ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.20437809
61ESR1_15608294_ChIP-ChIP_MCF-7_Human1.20196865
62* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19892864
63E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19575278
64KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18530332
65TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.17176438
66KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.17157338
67KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.17157338
68KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.17157338
69HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.13645530
70* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.10925869
71E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.10837208
72KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.10593255
73NANOG_21062744_ChIP-ChIP_HESCs_Human1.06924691
74TFEB_21752829_ChIP-Seq_HELA_Human1.05897833
75CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03808036
76TCF3_18692474_ChIP-Seq_MEFs_Mouse1.02852912
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00781098
78SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.99872791
79NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.99684179
80SOX17_20123909_ChIP-Seq_XEN_Mouse0.99107807
81YY1_21170310_ChIP-Seq_MESCs_Mouse0.97428664
82NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.95273004
83ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.94367850
84KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.94079249
85SRF_21415370_ChIP-Seq_HL-1_Mouse0.93876371
86SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.93871329
87PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.93441708
88POU5F1_16153702_ChIP-ChIP_HESCs_Human0.93196988
89CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92034303
90ERG_20887958_ChIP-Seq_HPC-7_Mouse0.91419849
91SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.90243585
92MYC_18940864_ChIP-ChIP_HL60_Human0.89143662
93HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.87663170
94TCF3_18692474_ChIP-Seq_MESCs_Mouse0.87541522
95ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.87297305
96NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.86790224
97* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86160618
98NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.85409975
99PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.84374836
100SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.83080168
101CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.82768247
102NANOG_16153702_ChIP-ChIP_HESCs_Human0.82041928
103CHD1_26751641_Chip-Seq_LNCaP_Human0.78270403
104SOX2_16153702_ChIP-ChIP_HESCs_Human0.76936597
105CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.74762574
106HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.74654807
107EWS_26573619_Chip-Seq_HEK293_Human0.72229198
108GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.71837191
109TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.69220446
110CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.68701768
111BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.67036356
112NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.65946761

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.88692816
2MP0003693_abnormal_embryo_hatching4.83690903
3* MP0003111_abnormal_nucleus_morphology4.44926164
4MP0004957_abnormal_blastocyst_morpholog4.17481709
5MP0008057_abnormal_DNA_replication4.06201657
6* MP0003077_abnormal_cell_cycle4.00963476
7MP0008058_abnormal_DNA_repair3.03818871
8MP0003123_paternal_imprinting2.79472060
9MP0008007_abnormal_cellular_replicative2.74563653
10MP0008932_abnormal_embryonic_tissue2.65181197
11MP0008877_abnormal_DNA_methylation2.65151930
12MP0001730_embryonic_growth_arrest2.54628227
13MP0010352_gastrointestinal_tract_polyps2.52330561
14MP0009697_abnormal_copulation2.34328885
15* MP0000350_abnormal_cell_proliferation2.28962542
16MP0003121_genomic_imprinting2.06900219
17MP0001672_abnormal_embryogenesis/_devel2.02317939
18MP0005380_embryogenesis_phenotype2.02317939
19* MP0010307_abnormal_tumor_latency1.96253695
20MP0001697_abnormal_embryo_size1.95829336
21MP0005076_abnormal_cell_differentiation1.89162434
22MP0010030_abnormal_orbit_morphology1.86908248
23MP0003890_abnormal_embryonic-extraembry1.85050016
24MP0002085_abnormal_embryonic_tissue1.84183887
25MP0002084_abnormal_developmental_patter1.82878290
26MP0003984_embryonic_growth_retardation1.78949064
27MP0003786_premature_aging1.75942276
28MP0002088_abnormal_embryonic_growth/wei1.75250679
29MP0002396_abnormal_hematopoietic_system1.69702666
30MP0002080_prenatal_lethality1.66268378
31* MP0004197_abnormal_fetal_growth/weight/1.66128726
32MP0003567_abnormal_fetal_cardiomyocyte1.66030524
33MP0002086_abnormal_extraembryonic_tissu1.64582951
34MP0000537_abnormal_urethra_morphology1.57987584
35MP0003705_abnormal_hypodermis_morpholog1.52701404
36MP0001293_anophthalmia1.50003843
37MP0009053_abnormal_anal_canal1.44548483
38* MP0002210_abnormal_sex_determination1.35162353
39MP0004808_abnormal_hematopoietic_stem1.33528711
40MP0000313_abnormal_cell_death1.33493852
41MP0003937_abnormal_limbs/digits/tail_de1.32781785
42MP0000490_abnormal_crypts_of1.31651389
43* MP0002019_abnormal_tumor_incidence1.21168563
44* MP0001145_abnormal_male_reproductive1.20633681
45MP0003119_abnormal_digestive_system1.16835404
46MP0001929_abnormal_gametogenesis1.15307028
47MP0006054_spinal_hemorrhage1.15252592
48MP0003315_abnormal_perineum_morphology1.11227318
49MP0006035_abnormal_mitochondrial_morpho1.08912807
50MP0004133_heterotaxia1.04243298
51* MP0000653_abnormal_sex_gland1.01928273
52MP0002111_abnormal_tail_morphology0.99554645
53MP0003941_abnormal_skin_development0.99120516
54MP0010234_abnormal_vibrissa_follicle0.97730672
55MP0001915_intracranial_hemorrhage0.96071924
56MP0001346_abnormal_lacrimal_gland0.94388779
57MP0003699_abnormal_female_reproductive0.93931477
58MP0000428_abnormal_craniofacial_morphol0.92840919
59MP0002653_abnormal_ependyma_morphology0.92157433
60MP0002092_abnormal_eye_morphology0.92099980
61MP0002877_abnormal_melanocyte_morpholog0.90845748
62* MP0009703_decreased_birth_body0.90468674
63MP0001849_ear_inflammation0.90256809
64MP0001661_extended_life_span0.89801438
65* MP0003718_maternal_effect0.87240321
66MP0008995_early_reproductive_senescence0.85909608
67* MP0009672_abnormal_birth_weight0.84848982
68MP0000432_abnormal_head_morphology0.83266981
69MP0003566_abnormal_cell_adhesion0.82964864
70MP0003136_yellow_coat_color0.82751343
71MP0000703_abnormal_thymus_morphology0.82605302
72MP0002697_abnormal_eye_size0.82550227
73MP0002938_white_spotting0.82228892
74MP0001286_abnormal_eye_development0.82094611
75MP0003806_abnormal_nucleotide_metabolis0.81049053
76MP0004185_abnormal_adipocyte_glucose0.81011515
77MP0000733_abnormal_muscle_development0.80486127
78MP0001119_abnormal_female_reproductive0.79507965
79MP0003115_abnormal_respiratory_system0.79501684
80MP0005384_cellular_phenotype0.78453517
81MP0005397_hematopoietic_system_phenotyp0.77974012
82MP0001545_abnormal_hematopoietic_system0.77974012
83MP0005023_abnormal_wound_healing0.77940299
84MP0003935_abnormal_craniofacial_develop0.76744153
85MP0009278_abnormal_bone_marrow0.76592378
86MP0002233_abnormal_nose_morphology0.75592428
87MP0005621_abnormal_cell_physiology0.75485063
88MP0002160_abnormal_reproductive_system0.73320422
89MP0002925_abnormal_cardiovascular_devel0.73267574
90MP0003861_abnormal_nervous_system0.71970428
91MP0003283_abnormal_digestive_organ0.71244683
92MP0003385_abnormal_body_wall0.69768627
93MP0003755_abnormal_palate_morphology0.69012307
94MP0003221_abnormal_cardiomyocyte_apopto0.68360163
95MP0000678_abnormal_parathyroid_gland0.67615483
96MP0008789_abnormal_olfactory_epithelium0.67273950
97MP0000566_synostosis0.67064908
98MP0003943_abnormal_hepatobiliary_system0.66852101
99MP0001529_abnormal_vocalization0.65992988
100MP0003698_abnormal_male_reproductive0.65920010
101MP0003787_abnormal_imprinting0.65905201
102MP0006292_abnormal_olfactory_placode0.63823797
103MP0002932_abnormal_joint_morphology0.63494158
104MP0004264_abnormal_extraembryonic_tissu0.61936166
105MP0001299_abnormal_eye_distance/0.61633272
106MP0000647_abnormal_sebaceous_gland0.61291359
107MP0005501_abnormal_skin_physiology0.61053598
108MP0002282_abnormal_trachea_morphology0.61043914
109MP0004233_abnormal_muscle_weight0.60758842
110MP0002102_abnormal_ear_morphology0.60649380
111MP0005389_reproductive_system_phenotype0.60479455
112MP0002722_abnormal_immune_system0.59686047
113MP0002009_preneoplasia0.59021585
114MP0002398_abnormal_bone_marrow0.58295900
115MP0000569_abnormal_digit_pigmentation0.58118986
116MP0002114_abnormal_axial_skeleton0.58052022
117MP0000579_abnormal_nail_morphology0.57935243
118MP0000358_abnormal_cell_content/0.57384836
119MP0002161_abnormal_fertility/fecundity0.56896991
120MP0006036_abnormal_mitochondrial_physio0.56751743
121MP0000266_abnormal_heart_morphology0.55496712
122MP0000477_abnormal_intestine_morphology0.54188617
123MP0002075_abnormal_coat/hair_pigmentati0.53448780
124MP0001727_abnormal_embryo_implantation0.52431108
125MP0003950_abnormal_plasma_membrane0.52069288
126MP0000372_irregular_coat_pigmentation0.51494937
127MP0003942_abnormal_urinary_system0.49181956

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.64592595
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.46597602
3Birth length less than 3rd percentile (HP:0003561)3.84600762
4Ependymoma (HP:0002888)3.80646373
5Medulloblastoma (HP:0002885)3.79411666
6Abnormality of chromosome stability (HP:0003220)3.77432184
7Colon cancer (HP:0003003)3.57595457
8Cortical dysplasia (HP:0002539)3.53145783
9Meckel diverticulum (HP:0002245)3.48406491
10Selective tooth agenesis (HP:0001592)3.36793271
11Volvulus (HP:0002580)3.36022123
12Aplasia/Hypoplasia of the uvula (HP:0010293)3.29675958
13Abnormality of the ileum (HP:0001549)3.28877795
14Reticulocytopenia (HP:0001896)3.19488556
15Impulsivity (HP:0100710)3.17721052
16Breast hypoplasia (HP:0003187)3.17349079
17Abnormality of the preputium (HP:0100587)3.15846665
18Abnormality of the labia minora (HP:0012880)3.14240060
19Patellar aplasia (HP:0006443)3.10719878
20Absent radius (HP:0003974)3.09331993
21* Embryonal renal neoplasm (HP:0011794)3.09171519
22Rhabdomyosarcoma (HP:0002859)3.05425798
23Ectopic kidney (HP:0000086)2.93928768
24Agnosia (HP:0010524)2.93087131
25Aplasia/Hypoplasia of the patella (HP:0006498)2.91050960
26Absent forearm bone (HP:0003953)2.87912122
27Aplasia involving forearm bones (HP:0009822)2.87912122
28Supernumerary spleens (HP:0009799)2.87340861
29Proximal placement of thumb (HP:0009623)2.79813380
30Deviation of the thumb (HP:0009603)2.75973815
31Abnormality of the astrocytes (HP:0100707)2.73545133
32Astrocytoma (HP:0009592)2.73545133
33Carpal bone hypoplasia (HP:0001498)2.70739292
34* Duodenal stenosis (HP:0100867)2.70501987
35* Small intestinal stenosis (HP:0012848)2.70501987
36Absent thumb (HP:0009777)2.68170027
37* Increased nuchal translucency (HP:0010880)2.61788009
38Short 4th metacarpal (HP:0010044)2.58986589
39Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.58986589
40Glioma (HP:0009733)2.52371388
41Abnormality of the carotid arteries (HP:0005344)2.49376681
42Abnormal number of incisors (HP:0011064)2.48855828
43Degeneration of anterior horn cells (HP:0002398)2.46441303
44Abnormality of the anterior horn cell (HP:0006802)2.46441303
45* Sloping forehead (HP:0000340)2.40373493
46* Myelodysplasia (HP:0002863)2.39876246
47Biliary tract neoplasm (HP:0100574)2.39719877
48Neoplasm of striated muscle (HP:0009728)2.39548122
49Neoplasm of the oral cavity (HP:0100649)2.37956284
5011 pairs of ribs (HP:0000878)2.36844614
51Duplicated collecting system (HP:0000081)2.36361737
52Duplication of thumb phalanx (HP:0009942)2.36063311
53Atresia of the external auditory canal (HP:0000413)2.33784431
54Oral leukoplakia (HP:0002745)2.31435741
55Neoplasm of the pancreas (HP:0002894)2.30373637
56Facial hemangioma (HP:0000329)2.29359796
57Aplasia/Hypoplasia of the sacrum (HP:0008517)2.28892966
58Aplasia/Hypoplasia of the sternum (HP:0006714)2.28770255
59Missing ribs (HP:0000921)2.28478471
60Basal cell carcinoma (HP:0002671)2.27262492
61* Abnormality of the duodenum (HP:0002246)2.26017580
62* Cafe-au-lait spot (HP:0000957)2.21149643
63High pitched voice (HP:0001620)2.20164738
64Multiple enchondromatosis (HP:0005701)2.19407980
65Abdominal situs inversus (HP:0003363)2.17872888
66Abnormality of abdominal situs (HP:0011620)2.17872888
67Tracheoesophageal fistula (HP:0002575)2.17094664
68Progressive external ophthalmoplegia (HP:0000590)2.17059627
69Bone marrow hypocellularity (HP:0005528)2.13851406
70Prominent nose (HP:0000448)2.13494822
71Short thumb (HP:0009778)2.11804537
72Aplasia/hypoplasia of the humerus (HP:0006507)2.10895396
73Abnormality of the renal collecting system (HP:0004742)2.07827984
74Gastrointestinal carcinoma (HP:0002672)2.07423127
75Malignant gastrointestinal tract tumors (HP:0006749)2.07423127
76Horseshoe kidney (HP:0000085)2.06922704
77Abnormality of cochlea (HP:0000375)2.01959685
78Abnormality of glycolysis (HP:0004366)2.01482722
79Microvesicular hepatic steatosis (HP:0001414)1.99750712
80Triphalangeal thumb (HP:0001199)1.99732922
81Rough bone trabeculation (HP:0100670)1.97488037
82* Abnormal lung lobation (HP:0002101)1.95769250
83Aplastic anemia (HP:0001915)1.95271289
84* Neoplasm of the colon (HP:0100273)1.93636717
85Clubbing of toes (HP:0100760)1.92176284
86Shoulder girdle muscle weakness (HP:0003547)1.91566096
87Short humerus (HP:0005792)1.90210814
88Squamous cell carcinoma (HP:0002860)1.90141141
89Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.89881956
90Premature graying of hair (HP:0002216)1.88423548
91Increased serum pyruvate (HP:0003542)1.87746151
92Skull defect (HP:0001362)1.87384409
93* Embryonal neoplasm (HP:0002898)1.86920044
94Sandal gap (HP:0001852)1.84963844
95High anterior hairline (HP:0009890)1.82622203
96Renal duplication (HP:0000075)1.82501732
97Amaurosis fugax (HP:0100576)1.80476844
98Long eyelashes (HP:0000527)1.80090458
99Abnormality of the 4th metacarpal (HP:0010012)1.79351467
100Choanal atresia (HP:0000453)1.78855703
101Abnormality of the calcaneus (HP:0008364)1.78279164
102Rib fusion (HP:0000902)1.78012635
103* Ovarian neoplasm (HP:0100615)1.77537161
104Deep philtrum (HP:0002002)1.77278506
105Uterine neoplasm (HP:0010784)1.77004145
106Arteriovenous malformation (HP:0100026)1.75524505
107Overlapping toe (HP:0001845)1.75491703
108Abnormality of chromosome segregation (HP:0002916)1.74138245
109Abnormality of DNA repair (HP:0003254)1.72324983
110Cutaneous melanoma (HP:0012056)1.71570025
111Hypoplasia of the capital femoral epiphysis (HP:0003090)1.71140813
112Facial cleft (HP:0002006)1.70990317
113* Nephroblastoma (Wilms tumor) (HP:0002667)1.70556952
114Uterine leiomyosarcoma (HP:0002891)1.70221080
115Leiomyosarcoma (HP:0100243)1.70221080
116Urethral obstruction (HP:0000796)1.69958053
117Supernumerary bones of the axial skeleton (HP:0009144)1.68851706
118Abnormality of cells of the erythroid lineage (HP:0012130)1.68453783
119Capillary hemangiomas (HP:0005306)1.66371165
120Acute myeloid leukemia (HP:0004808)1.66097335
121Aplasia/Hypoplasia of the earlobes (HP:0009906)1.64673347
122Gonadotropin excess (HP:0000837)1.63577721
123Broad distal phalanx of finger (HP:0009836)1.61938183
124Cholecystitis (HP:0001082)1.61145728
125Abnormal gallbladder physiology (HP:0012438)1.61145728
126Abnormality of methionine metabolism (HP:0010901)1.59277685
127Pancreatic islet-cell hyperplasia (HP:0004510)1.59157370
128Abnormality of the fetal cardiovascular system (HP:0010948)1.58722555
129Abnormal umbilical cord blood vessels (HP:0011403)1.58722555
130Single umbilical artery (HP:0001195)1.58722555

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.92437654
2BUB14.30578368
3WEE14.21563620
4NEK23.61659687
5TTK3.20133533
6NEK13.15125445
7CDK122.62782503
8SRPK12.58170608
9PLK42.31331057
10PLK12.26934915
11EIF2AK12.26494095
12BRSK22.26230506
13MKNK11.96714492
14AURKB1.96658216
15ATR1.91694325
16PLK31.89027767
17PASK1.87928856
18ACVR1B1.86644494
19VRK21.81097974
20TSSK61.75800869
21CHEK21.74301900
22CDK71.63515814
23TAF11.58570917
24EEF2K1.57515757
25MAP3K81.51369047
26RPS6KB21.50038430
27CHEK11.47460069
28STK101.46990804
29CDK41.46417773
30STK41.43940484
31BRSK11.40312026
32MKNK21.34383047
33CCNB11.30047210
34BRD41.29603824
35CDK61.29221466
36PAK41.25955828
37RPS6KA41.23966664
38AURKA1.21498432
39VRK11.20521740
40TLK11.19715393
41SMG11.19196824
42DYRK31.17023822
43* ATM1.15537408
44MST41.15056091
45PKN21.13895800
46SCYL21.12520650
47STK31.10445892
48MELK1.10045269
49MAP3K101.09991512
50EIF2AK31.07893991
51TESK21.07423928
52TGFBR11.05227886
53EPHA21.03143896
54CDK21.00711814
55PNCK0.92641034
56ZAK0.92126987
57PDK20.91225894
58PBK0.85841330
59LATS10.85530130
60* CDK10.83252205
61FLT30.82993839
62ALK0.82403113
63STK38L0.78704544
64TRIM280.76049900
65NUAK10.73525094
66PIM10.64392310
67MTOR0.63328359
68BRAF0.58557666
69NME20.58045294
70CSNK2A20.57569937
71TNIK0.56747198
72PDK40.55681498
73PDK30.55681498
74ERBB40.55232921
75CSNK2A10.53095741
76PAK10.52165218
77MST1R0.51791842
78EIF2AK20.50741904
79PRKDC0.50377531
80NME10.49740078
81LRRK20.48433521
82LATS20.48076566
83PLK20.47807727
84FGFR10.47417198
85CLK10.46172337
86TESK10.44586527
87AKT20.43942974
88CSNK1D0.43603968
89TTN0.42169838
90CDK11A0.41773367
91CDK180.41745538
92RPS6KA50.41084126
93CDK150.40620567
94CSNK1E0.40194456
95MARK30.39126608
96BCR0.38234290
97MAP3K90.36655543
98CDK80.36147516
99MAPK140.35436923
100BMX0.35269984
101PRKCI0.35200933
102RAF10.34761619
103CDK30.33944053
104PAK20.33168047
105STK160.32096359
106CDK140.31450941
107KSR10.31075174
108AKT10.29582998
109CDK90.28385770
110CAMK1G0.25404030
111GSK3B0.24460012
112MAPK10.24357386
113ICK0.21161222
114PTK60.20809297
115BMPR1B0.19458204
116KSR20.18679497
117CDK190.18653477
118RPS6KB10.18463655
119MAP2K30.18263628
120ERBB30.16141542
121CSNK1G30.16048132
122YES10.15838216
123NEK90.14984599
124CSNK1A1L0.14888527
125PDGFRA0.14628243
126MET0.14138591

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.02617685
2Mismatch repair_Homo sapiens_hsa034304.55193384
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.48959970
4RNA transport_Homo sapiens_hsa030133.40422025
5* Cell cycle_Homo sapiens_hsa041103.36063246
6Spliceosome_Homo sapiens_hsa030403.32849696
7Homologous recombination_Homo sapiens_hsa034403.12177238
8Base excision repair_Homo sapiens_hsa034103.07746634
9Nucleotide excision repair_Homo sapiens_hsa034202.89075860
10One carbon pool by folate_Homo sapiens_hsa006702.88442668
11Fanconi anemia pathway_Homo sapiens_hsa034602.80734633
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.48508949
13Non-homologous end-joining_Homo sapiens_hsa034502.39476349
14RNA polymerase_Homo sapiens_hsa030202.29354592
15mRNA surveillance pathway_Homo sapiens_hsa030152.15160374
16Proteasome_Homo sapiens_hsa030502.11363301
17Ribosome_Homo sapiens_hsa030102.09421746
18RNA degradation_Homo sapiens_hsa030182.06965069
19Basal transcription factors_Homo sapiens_hsa030221.96772420
20Pyrimidine metabolism_Homo sapiens_hsa002401.95196421
21Systemic lupus erythematosus_Homo sapiens_hsa053221.82735264
22p53 signaling pathway_Homo sapiens_hsa041151.82308516
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.73720118
24* Oocyte meiosis_Homo sapiens_hsa041141.40913647
25Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.39851117
26Pyruvate metabolism_Homo sapiens_hsa006201.39245578
27Viral carcinogenesis_Homo sapiens_hsa052031.31352517
28* Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.27131358
29Epstein-Barr virus infection_Homo sapiens_hsa051691.17502160
30MicroRNAs in cancer_Homo sapiens_hsa052061.14889999
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.11916169
32Protein export_Homo sapiens_hsa030601.07373736
33Steroid biosynthesis_Homo sapiens_hsa001001.06080594
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.04688611
35Herpes simplex infection_Homo sapiens_hsa051680.99342987
36HTLV-I infection_Homo sapiens_hsa051660.98657059
37Purine metabolism_Homo sapiens_hsa002300.98344219
38Propanoate metabolism_Homo sapiens_hsa006400.95341857
39Antigen processing and presentation_Homo sapiens_hsa046120.91436385
40Selenocompound metabolism_Homo sapiens_hsa004500.90226650
41Basal cell carcinoma_Homo sapiens_hsa052170.86277002
42Small cell lung cancer_Homo sapiens_hsa052220.85835848
43Hippo signaling pathway_Homo sapiens_hsa043900.82109329
44Biosynthesis of amino acids_Homo sapiens_hsa012300.81486340
45TGF-beta signaling pathway_Homo sapiens_hsa043500.81016319
46Alcoholism_Homo sapiens_hsa050340.79436019
47Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.79295281
48Thyroid cancer_Homo sapiens_hsa052160.77598389
49Colorectal cancer_Homo sapiens_hsa052100.69875398
50Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.69844206
51Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68580045
52Adherens junction_Homo sapiens_hsa045200.67923587
53Cysteine and methionine metabolism_Homo sapiens_hsa002700.66657104
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65383006
55Fatty acid elongation_Homo sapiens_hsa000620.59671134
56Pentose phosphate pathway_Homo sapiens_hsa000300.59233335
57Sulfur relay system_Homo sapiens_hsa041220.57019155
58Huntingtons disease_Homo sapiens_hsa050160.55412321
59Hedgehog signaling pathway_Homo sapiens_hsa043400.54659646
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53956735
61Legionellosis_Homo sapiens_hsa051340.51740503
62Central carbon metabolism in cancer_Homo sapiens_hsa052300.51063696
63Chronic myeloid leukemia_Homo sapiens_hsa052200.50355474
64Lysine degradation_Homo sapiens_hsa003100.49647181
65Vitamin B6 metabolism_Homo sapiens_hsa007500.49495455
66Notch signaling pathway_Homo sapiens_hsa043300.47227173
67Drug metabolism - other enzymes_Homo sapiens_hsa009830.46527881
68mTOR signaling pathway_Homo sapiens_hsa041500.45838360
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.45639985
70Cyanoamino acid metabolism_Homo sapiens_hsa004600.44625858
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43697161
72Apoptosis_Homo sapiens_hsa042100.42730696
73Pathways in cancer_Homo sapiens_hsa052000.42704586
74Parkinsons disease_Homo sapiens_hsa050120.42508551
75Hepatitis B_Homo sapiens_hsa051610.42368450
76Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42367250
77Bladder cancer_Homo sapiens_hsa052190.41571922
78Prostate cancer_Homo sapiens_hsa052150.40520833
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39639576
80Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.39312808
81HIF-1 signaling pathway_Homo sapiens_hsa040660.39102430
82Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38277940
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37910338
84Viral myocarditis_Homo sapiens_hsa054160.36531148
85Carbon metabolism_Homo sapiens_hsa012000.35411163
86Proteoglycans in cancer_Homo sapiens_hsa052050.33986417
87Wnt signaling pathway_Homo sapiens_hsa043100.32444408
88Tight junction_Homo sapiens_hsa045300.32372235
89Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.30324848
90Non-small cell lung cancer_Homo sapiens_hsa052230.29755354
91Fatty acid metabolism_Homo sapiens_hsa012120.29389539
92FoxO signaling pathway_Homo sapiens_hsa040680.26667709
93Metabolic pathways_Homo sapiens_hsa011000.26539036
94Shigellosis_Homo sapiens_hsa051310.25563613
95Influenza A_Homo sapiens_hsa051640.24753192
96NOD-like receptor signaling pathway_Homo sapiens_hsa046210.24493382
97Pancreatic cancer_Homo sapiens_hsa052120.24198258
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.24051845
99Endometrial cancer_Homo sapiens_hsa052130.23460303
100Melanoma_Homo sapiens_hsa052180.23446725
101Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.22625026
102Glutathione metabolism_Homo sapiens_hsa004800.22002004
103NF-kappa B signaling pathway_Homo sapiens_hsa040640.21956318
104Measles_Homo sapiens_hsa051620.21386130
105Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.20777814
106Leukocyte transendothelial migration_Homo sapiens_hsa046700.17607468
107PI3K-Akt signaling pathway_Homo sapiens_hsa041510.16768506
108N-Glycan biosynthesis_Homo sapiens_hsa005100.16750340
109Arginine and proline metabolism_Homo sapiens_hsa003300.14076636
110Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.12908046
111Folate biosynthesis_Homo sapiens_hsa007900.12855503
1122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.11598132
113Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.11557984
114Primary immunodeficiency_Homo sapiens_hsa053400.11220324
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.10476939
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.10450356
117Fructose and mannose metabolism_Homo sapiens_hsa000510.09330383
118Galactose metabolism_Homo sapiens_hsa000520.09116858
119Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.08715154
120Focal adhesion_Homo sapiens_hsa045100.08467404
121Renin-angiotensin system_Homo sapiens_hsa046140.08208219
122Acute myeloid leukemia_Homo sapiens_hsa052210.07707868

Most similar genes based on co-expression Upload to Enrichr

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