BUB3P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine ribonucleoside catabolic process (GO:0046133)9.52430850
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450919.05241911
3DNA deamination (GO:0045006)8.99649489
4water-soluble vitamin biosynthetic process (GO:0042364)5.59220764
5negative regulation by host of viral transcription (GO:0043922)5.43568443
6regulation of T cell chemotaxis (GO:0010819)4.71179673
7positive regulation of T cell chemotaxis (GO:0010820)4.71179673
8regulation of lymphocyte chemotaxis (GO:1901623)4.55191397
9DNA demethylation (GO:0080111)4.31037605
10negative T cell selection (GO:0043383)4.24154590
11pyrimidine nucleoside catabolic process (GO:0046135)4.23851614
12proteasome assembly (GO:0043248)4.22059806
13DNA dealkylation (GO:0035510)4.17289668
14T cell migration (GO:0072678)4.13211392
15negative regulation of T cell apoptotic process (GO:0070233)3.95361797
16positive regulation of macrophage differentiation (GO:0045651)3.94740302
17tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.89685094
18RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.89685094
19positive regulation of alpha-beta T cell proliferation (GO:0046641)3.80553382
20positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.80321457
21positive regulation of lymphocyte migration (GO:2000403)3.64284665
22rRNA modification (GO:0000154)3.58904524
23positive T cell selection (GO:0043368)3.56250745
24positive regulation of calcium-mediated signaling (GO:0050850)3.55217784
25negative regulation of viral genome replication (GO:0045071)3.51043985
26positive regulation of defense response to virus by host (GO:0002230)3.48765852
27cyclooxygenase pathway (GO:0019371)3.44882070
28rRNA methylation (GO:0031167)3.44734655
29signal peptide processing (GO:0006465)3.38136977
30positive regulation of monocyte chemotaxis (GO:0090026)3.37675617
31regulation of alpha-beta T cell proliferation (GO:0046640)3.27455374
32ketone body metabolic process (GO:1902224)3.24952909
33modulation by host of viral transcription (GO:0043921)3.21447655
34modulation by host of symbiont transcription (GO:0052472)3.21447655
35cellular ketone body metabolic process (GO:0046950)3.21022404
36lymphocyte chemotaxis (GO:0048247)3.18891121
37positive regulation of T cell mediated cytotoxicity (GO:0001916)3.17570907
38dendritic cell chemotaxis (GO:0002407)3.16331483
39regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.13608573
40modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)3.13448567
41attachment of spindle microtubules to kinetochore (GO:0008608)3.11863711
42negative thymic T cell selection (GO:0045060)3.11430907
43cellular response to interleukin-15 (GO:0071350)3.11334831
44regulation of calcium-mediated signaling (GO:0050848)3.09855501
45adenosine metabolic process (GO:0046085)3.09021740
46negative regulation of viral transcription (GO:0032897)3.07618546
47negative regulation of calcium ion transport into cytosol (GO:0010523)3.05659722
48cellular defense response (GO:0006968)3.00035462
49thrombin receptor signaling pathway (GO:0070493)2.99939352
50protein neddylation (GO:0045116)2.97887405
51positive regulation of T cell migration (GO:2000406)2.94974498
52platelet dense granule organization (GO:0060155)2.94354286
53pyrimidine ribonucleoside metabolic process (GO:0046131)2.88221214
54regulation of regulatory T cell differentiation (GO:0045589)2.87634455
55positive thymic T cell selection (GO:0045059)2.84903514
56positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.84809385
57positive regulation of interleukin-1 beta secretion (GO:0050718)2.83579385
58S-adenosylmethionine metabolic process (GO:0046500)2.83044085
59regulation of T-helper 1 type immune response (GO:0002825)2.82331666
60kynurenine metabolic process (GO:0070189)2.81123269
61protein polyglutamylation (GO:0018095)2.79731494
62negative regulation of lymphocyte apoptotic process (GO:0070229)2.78947062
63eosinophil chemotaxis (GO:0048245)2.77445929
64positive regulation of T-helper 1 type immune response (GO:0002827)2.74910415
65regulation of B cell receptor signaling pathway (GO:0050855)2.71405311
66adaptation of signaling pathway (GO:0023058)2.68066676
67indolalkylamine metabolic process (GO:0006586)2.66028698
68positive regulation of interleukin-1 secretion (GO:0050716)2.65675742
69behavioral response to nicotine (GO:0035095)2.65618310
70regulation of T cell mediated cytotoxicity (GO:0001914)2.65077036
71dendritic cell migration (GO:0036336)2.64892020
72positive regulation of B cell differentiation (GO:0045579)2.63802930
73regulation of interleukin-1 beta secretion (GO:0050706)2.62110911
74tryptophan metabolic process (GO:0006568)2.60931461
75negative regulation of viral process (GO:0048525)2.60444582
76response to interleukin-15 (GO:0070672)2.59758866
77lymphocyte migration (GO:0072676)2.58054755
78protein complex biogenesis (GO:0070271)2.57615264
79pyrimidine-containing compound catabolic process (GO:0072529)2.56842013
80tryptophan catabolic process (GO:0006569)2.54365708
81indole-containing compound catabolic process (GO:0042436)2.54365708
82indolalkylamine catabolic process (GO:0046218)2.54365708
83macrophage chemotaxis (GO:0048246)2.52189960
84regulation of B cell differentiation (GO:0045577)2.51551938
85negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.50464995
86eosinophil migration (GO:0072677)2.50143493
87negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.46623624
88multicellular organism reproduction (GO:0032504)2.44861638
89positive regulation of cell killing (GO:0031343)2.44498704
90response to inactivity (GO:0014854)2.43852268
91detection of light stimulus involved in visual perception (GO:0050908)2.43393240
92detection of light stimulus involved in sensory perception (GO:0050962)2.43393240
93response to pheromone (GO:0019236)2.43036285
94cytolysis (GO:0019835)2.41993396
95regulation of memory T cell differentiation (GO:0043380)2.41949226
96regulation of T cell migration (GO:2000404)2.41062577
97regulation of cell killing (GO:0031341)2.40875117
98cytidine metabolic process (GO:0046087)10.9206697
99cytidine catabolic process (GO:0006216)10.9206697
100cytidine deamination (GO:0009972)10.9206697

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human3.81174648
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.77556639
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.60345161
4ELF1_17652178_ChIP-ChIP_JURKAT_Human3.13042864
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.03533845
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.89657289
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.88841143
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.85006526
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.72636555
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.69210612
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.55824529
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.45987216
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.41887893
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.38174319
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.24109300
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.20021617
17ZNF274_21170338_ChIP-Seq_K562_Hela2.18221533
18SMAD_19615063_ChIP-ChIP_OVARY_Human1.98291374
19NOTCH1_21737748_ChIP-Seq_TLL_Human1.91030096
20MYB_26560356_Chip-Seq_TH2_Human1.90686754
21ELK1_19687146_ChIP-ChIP_HELA_Human1.90392149
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89652378
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.88858837
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.77349685
25GATA3_26560356_Chip-Seq_TH2_Human1.74170671
26FOXA1_21572438_ChIP-Seq_LNCaP_Human1.67028554
27EWS_26573619_Chip-Seq_HEK293_Human1.64911837
28RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64231607
29FOXA1_25329375_ChIP-Seq_VCAP_Human1.63393269
30FOXA1_27270436_Chip-Seq_PROSTATE_Human1.63393269
31IRF8_21731497_ChIP-ChIP_J774_Mouse1.62863526
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.60259205
33FOXP3_21729870_ChIP-Seq_TREG_Human1.59731052
34NANOG_19829295_ChIP-Seq_ESCs_Human1.56077736
35SOX2_19829295_ChIP-Seq_ESCs_Human1.56077736
36VDR_23849224_ChIP-Seq_CD4+_Human1.53887428
37IRF8_22096565_ChIP-ChIP_GC-B_Human1.51186525
38HTT_18923047_ChIP-ChIP_STHdh_Human1.50641719
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.49556840
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.49520398
41P300_19829295_ChIP-Seq_ESCs_Human1.45199696
42STAT6_21828071_ChIP-Seq_BEAS2B_Human1.45136873
43CBP_20019798_ChIP-Seq_JUKART_Human1.44376130
44IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44376130
45CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.42375593
46RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.42065258
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40659948
48EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.38761780
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38216125
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.37521749
51NFE2_27457419_Chip-Seq_LIVER_Mouse1.36945760
52LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.35919038
53PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33956403
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.33449901
55PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.32546059
56SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31357801
57AR_20517297_ChIP-Seq_VCAP_Human1.30777177
58EGR1_23403033_ChIP-Seq_LIVER_Mouse1.28741734
59GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.27605746
60CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.27396018
61GATA3_27048872_Chip-Seq_THYMUS_Human1.27170439
62GBX2_23144817_ChIP-Seq_PC3_Human1.26055766
63IRF1_19129219_ChIP-ChIP_H3396_Human1.25163475
64STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.24881147
65SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.22654359
66MYC_18940864_ChIP-ChIP_HL60_Human1.22471257
67JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.22104189
68RUNX_20019798_ChIP-Seq_JUKART_Human1.21950140
69SRF_21415370_ChIP-Seq_HL-1_Mouse1.19335186
70BCAT_22108803_ChIP-Seq_LS180_Human1.19173331
71E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.15891952
72STAT4_19710469_ChIP-ChIP_TH1__Mouse1.15565468
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15446260
74CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.15436619
75TP53_22573176_ChIP-Seq_HFKS_Human1.13083404
76NCOR_22424771_ChIP-Seq_293T_Human1.11693642
77TAF2_19829295_ChIP-Seq_ESCs_Human1.11626116
78ER_23166858_ChIP-Seq_MCF-7_Human1.11454962
79CRX_20693478_ChIP-Seq_RETINA_Mouse1.11116005
80GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10199722
81NANOG_20526341_ChIP-Seq_ESCs_Human1.10169972
82CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07732700
83PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.06782186
84GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.04839665
85AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04133957
86FUS_26573619_Chip-Seq_HEK293_Human1.03907609
87CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03888489
88GATA3_21878914_ChIP-Seq_MCF-7_Human1.03602806
89PRDM14_20953172_ChIP-Seq_ESCs_Human1.02553785
90SMAD4_21741376_ChIP-Seq_EPCs_Human1.02093488
91E2F4_17652178_ChIP-ChIP_JURKAT_Human1.01992971
92NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01326625
93ETS1_20019798_ChIP-Seq_JURKAT_Human1.00784947
94TAF15_26573619_Chip-Seq_HEK293_Human0.99877408
95CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.99724246
96SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98779962
97KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98702143
98CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.97531782
99FOXH1_21741376_ChIP-Seq_EPCs_Human0.96177384
100FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.95624644

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.12992942
2MP0000569_abnormal_digit_pigmentation3.88763250
3MP0002138_abnormal_hepatobiliary_system3.62063746
4MP0002102_abnormal_ear_morphology3.21546394
5MP0003763_abnormal_thymus_physiology2.79077449
6MP0009333_abnormal_splenocyte_physiolog2.69237816
7MP0002148_abnormal_hypersensitivity_rea2.51205727
8MP0003646_muscle_fatigue2.41117910
9MP0001986_abnormal_taste_sensitivity2.31255490
10MP0008007_abnormal_cellular_replicative2.12463711
11MP0003786_premature_aging2.03739856
12MP0000372_irregular_coat_pigmentation2.02844705
13MP0003866_abnormal_defecation1.99202785
14MP0006082_CNS_inflammation1.99018297
15MP0001790_abnormal_immune_system1.83971112
16MP0005387_immune_system_phenotype1.83971112
17MP0002736_abnormal_nociception_after1.77265965
18MP0005408_hypopigmentation1.75432556
19MP0001501_abnormal_sleep_pattern1.73278110
20MP0002166_altered_tumor_susceptibility1.68899202
21MP0005075_abnormal_melanosome_morpholog1.67777233
22MP0005000_abnormal_immune_tolerance1.64653665
23MP0009785_altered_susceptibility_to1.64632831
24MP0001919_abnormal_reproductive_system1.64225936
25MP0003195_calcinosis1.63637612
26MP0002723_abnormal_immune_serum1.62307193
27MP0001800_abnormal_humoral_immune1.60032346
28MP0006072_abnormal_retinal_apoptosis1.59347726
29MP0001968_abnormal_touch/_nociception1.57924223
30MP0002876_abnormal_thyroid_physiology1.54531932
31MP0002163_abnormal_gland_morphology1.53645021
32MP0002420_abnormal_adaptive_immunity1.51303343
33MP0001819_abnormal_immune_cell1.51006864
34MP0006276_abnormal_autonomic_nervous1.47921783
35MP0004885_abnormal_endolymph1.44990442
36MP0001835_abnormal_antigen_presentation1.42273570
37MP0000703_abnormal_thymus_morphology1.39721610
38MP0001243_abnormal_dermal_layer1.36866645
39MP0003448_altered_tumor_morphology1.35880979
40MP0002452_abnormal_antigen_presenting1.30843273
41MP0005645_abnormal_hypothalamus_physiol1.29820235
42MP0005464_abnormal_platelet_physiology1.29799398
43MP0003718_maternal_effect1.29188339
44MP0005253_abnormal_eye_physiology1.28652017
45MP0005167_abnormal_blood-brain_barrier1.28204956
46MP0008872_abnormal_physiological_respon1.27936538
47MP0010155_abnormal_intestine_physiology1.27555889
48MP0000716_abnormal_immune_system1.27434043
49MP0002398_abnormal_bone_marrow1.26704593
50MP0000689_abnormal_spleen_morphology1.26080459
51MP0002006_tumorigenesis1.24789053
52MP0002722_abnormal_immune_system1.23602619
53MP0005174_abnormal_tail_pigmentation1.23574803
54MP0002277_abnormal_respiratory_mucosa1.21823680
55MP0005171_absent_coat_pigmentation1.20682089
56MP0002653_abnormal_ependyma_morphology1.20155101
57MP0010386_abnormal_urinary_bladder1.19218707
58MP0008875_abnormal_xenobiotic_pharmacok1.17295431
59MP0000685_abnormal_immune_system1.16296765
60MP0003724_increased_susceptibility_to1.12953148
61MP0004381_abnormal_hair_follicle1.11828969
62MP0005025_abnormal_response_to1.11700733
63MP0005410_abnormal_fertilization1.11428665
64MP0001845_abnormal_inflammatory_respons1.09519688
65MP0000604_amyloidosis1.08584097
66MP0000427_abnormal_hair_cycle1.08553411
67MP0005551_abnormal_eye_electrophysiolog1.06820786
68MP0002396_abnormal_hematopoietic_system1.04016436
69MP0001984_abnormal_olfaction1.03458022
70MP0008058_abnormal_DNA_repair1.02821231
71MP0002095_abnormal_skin_pigmentation1.02557277
72MP0005389_reproductive_system_phenotype1.01758655
73MP0002638_abnormal_pupillary_reflex1.01421115
74MP0008873_increased_physiological_sensi1.01362963
75MP0002837_dystrophic_cardiac_calcinosis1.00631085
76MP0002733_abnormal_thermal_nociception1.00554033
77MP0004142_abnormal_muscle_tone1.00368422
78MP0009745_abnormal_behavioral_response1.00055867
79MP0003011_delayed_dark_adaptation0.99678579
80MP0005646_abnormal_pituitary_gland0.96103245
81MP0001905_abnormal_dopamine_level0.95839720
82MP0009764_decreased_sensitivity_to0.95628365
83MP0002429_abnormal_blood_cell0.91344855
84MP0009046_muscle_twitch0.90212753
85MP0005379_endocrine/exocrine_gland_phen0.87473597
86MP0001542_abnormal_bone_strength0.86919215
87MP0000647_abnormal_sebaceous_gland0.86099726
88MP0002735_abnormal_chemical_nociception0.84176506
89MP0001119_abnormal_female_reproductive0.81933602
90MP0010094_abnormal_chromosome_stability0.81575835
91MP0001765_abnormal_ion_homeostasis0.81195938
92MP0004742_abnormal_vestibular_system0.81190844
93MP0009763_increased_sensitivity_to0.80314231
94MP0005377_hearing/vestibular/ear_phenot0.79762721
95MP0003878_abnormal_ear_physiology0.79762721
96MP0010307_abnormal_tumor_latency0.77689135
97MP0001293_anophthalmia0.77317711
98MP0006036_abnormal_mitochondrial_physio0.77302556
99MP0002234_abnormal_pharynx_morphology0.72123579
100MP0001970_abnormal_pain_threshold0.72072386

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)4.99526028
2Abnormality of T cell number (HP:0011839)4.49629834
3T lymphocytopenia (HP:0005403)4.41528365
4IgG deficiency (HP:0004315)4.32469876
5Methylmalonic acidemia (HP:0002912)3.88043802
6Autoimmune hemolytic anemia (HP:0001890)3.80033571
7Eosinophilia (HP:0001880)3.70158003
8Prostate neoplasm (HP:0100787)3.69154695
9Renal cortical cysts (HP:0000803)3.67685196
10Abnormality of T cells (HP:0002843)3.59058291
11Type I transferrin isoform profile (HP:0003642)3.58998356
12Abnormality of eosinophils (HP:0001879)3.44146389
13Pancreatic cysts (HP:0001737)3.31300384
14Severe combined immunodeficiency (HP:0004430)3.30323898
15Abnormality of the prostate (HP:0008775)3.26459535
16Hypoplasia of the pons (HP:0012110)3.24369256
17B lymphocytopenia (HP:0010976)3.20581984
18Increased neuronal autofluorescent lipopigment (HP:0002074)3.19439408
19Hypoplasia of the thymus (HP:0000778)3.18221567
20Reduced antithrombin III activity (HP:0001976)3.17129028
21Abnormality of B cell number (HP:0010975)3.14798492
22Hypoproteinemia (HP:0003075)3.14478435
23Methylmalonic aciduria (HP:0012120)3.08149432
24Chronic diarrhea (HP:0002028)2.97384838
25Abnormality of the pons (HP:0007361)2.90271217
26Abnormality of T cell physiology (HP:0011840)2.85433511
27Combined immunodeficiency (HP:0005387)2.80058893
28Granulocytopenia (HP:0001913)2.78055367
29Pancytopenia (HP:0001876)2.70592579
30Cerebral palsy (HP:0100021)2.69794570
31Abnormality of the renal cortex (HP:0011035)2.69277547
32Thyroiditis (HP:0100646)2.67153958
33Chromosomal breakage induced by crosslinking agents (HP:0003221)2.61794556
34Congenital stationary night blindness (HP:0007642)2.61750888
35Abnormal delayed hypersensitivity skin test (HP:0002963)2.59610852
36Abnormal glycosylation (HP:0012345)2.59441607
37Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.59441607
38Abnormal protein N-linked glycosylation (HP:0012347)2.59441607
39Abnormal protein glycosylation (HP:0012346)2.59441607
40Autoimmune thrombocytopenia (HP:0001973)2.58696681
41Increased cerebral lipofuscin (HP:0011813)2.56211416
42Panhypogammaglobulinemia (HP:0003139)2.55418461
43Aplasia/hypoplasia of the uterus (HP:0008684)2.54846300
44Abolished electroretinogram (ERG) (HP:0000550)2.52660410
45Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.52535676
46IgM deficiency (HP:0002850)2.52025768
47Chromsome breakage (HP:0040012)2.44046796
48Abnormality of the vitamin B12 metabolism (HP:0004341)2.41324877
49Decreased electroretinogram (ERG) amplitude (HP:0000654)2.38676031
50True hermaphroditism (HP:0010459)2.36943519
51Nephroblastoma (Wilms tumor) (HP:0002667)2.36599557
52Cutaneous melanoma (HP:0012056)2.35678115
53Pancreatic fibrosis (HP:0100732)2.35595450
54Recurrent bronchitis (HP:0002837)2.33992302
55Joint swelling (HP:0001386)2.30128303
56Increased intramyocellular lipid droplets (HP:0012240)2.28558209
57Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.25589333
58Embryonal renal neoplasm (HP:0011794)2.24374210
59Abnormality of vitamin B metabolism (HP:0004340)2.21723165
60Leukocytosis (HP:0001974)2.21687658
61Aplasia/Hypoplasia of the tibia (HP:0005772)2.18822132
62Increased CSF lactate (HP:0002490)2.18238795
63Glucose intolerance (HP:0000833)2.12887653
64Abnormal lung lobation (HP:0002101)2.12589845
65Stomach cancer (HP:0012126)2.11695632
66Mitochondrial inheritance (HP:0001427)2.11678304
67Lipid accumulation in hepatocytes (HP:0006561)2.11101110
68Agammaglobulinemia (HP:0004432)2.09132651
69Attenuation of retinal blood vessels (HP:0007843)2.06630113
70Erythroderma (HP:0001019)2.05260096
71Abnormality of alanine metabolism (HP:0010916)2.04057135
72Hyperalaninemia (HP:0003348)2.04057135
73Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.04057135
74Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.03052500
75Increased IgM level (HP:0003496)2.02097373
76Hypoplasia of the uterus (HP:0000013)2.01161835
77Bronchitis (HP:0012387)2.00014457
78Increased hepatocellular lipid droplets (HP:0006565)1.99556213
79Increased muscle lipid content (HP:0009058)1.97940467
80Abnormality of dicarboxylic acid metabolism (HP:0010995)1.96285939
81Dicarboxylic aciduria (HP:0003215)1.96285939
82Large for gestational age (HP:0001520)1.93840351
83Pendular nystagmus (HP:0012043)1.93332678
84Abnormality of macular pigmentation (HP:0008002)1.92624743
85Abnormality of male internal genitalia (HP:0000022)1.91210332
86Recurrent viral infections (HP:0004429)1.89891412
87Neutropenia (HP:0001875)1.89858348
883-Methylglutaconic aciduria (HP:0003535)1.87947866
89Congenital, generalized hypertrichosis (HP:0004540)1.83780529
90Abnormality of the ileum (HP:0001549)1.81755429
91Decreased central vision (HP:0007663)1.81300548
92Abnormality of homocysteine metabolism (HP:0010919)1.80393804
93Homocystinuria (HP:0002156)1.80393804
94Encephalitis (HP:0002383)1.79764941
95Carpal bone hypoplasia (HP:0001498)1.76730968
96Acute necrotizing encephalopathy (HP:0006965)1.76377481
97Dyskinesia (HP:0100660)1.75485944
98Abnormal respiratory motile cilium physiology (HP:0012261)1.74584658
99Sclerocornea (HP:0000647)1.74414671
100Abnormal mitochondria in muscle tissue (HP:0008316)1.74361606

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB17.41279709
2FRK4.72245619
3ZAK3.12910239
4KDR2.82873732
5ADRBK22.53066868
6TLK12.49326626
7TXK2.48176144
8WEE12.21233896
9PDK22.17954300
10ITK2.09932280
11RIPK41.93600996
12MST41.92986141
13PLK21.91403914
14EIF2AK31.89307251
15STK38L1.87887161
16RIPK11.79252246
17SRPK11.78368284
18PIK3CA1.70808159
19SCYL21.65645474
20MAPKAPK31.51820146
21ACVR1B1.44113592
22MAP4K11.43692802
23TAOK31.37108755
24MAP2K71.30810506
25MAP4K21.29974721
26GRK11.28264615
27STK161.27845799
28NUAK11.22684522
29WNK41.21657710
30MYLK1.20661709
31BMPR21.17085002
32IKBKB1.16489088
33VRK11.14644365
34GRK61.13484187
35FES1.04156727
36WNK31.03286845
37PINK11.00735307
38STK30.99559217
39BMPR1B0.98456319
40STK240.96665192
41PLK40.96471415
42TNK20.91673278
43SYK0.86386385
44PRKCQ0.85970747
45NEK60.85961878
46BCKDK0.85124309
47TESK20.83160035
48BRSK20.80092051
49MAPK130.79484242
50EIF2AK20.76112771
51ERBB20.72769272
52PIK3CG0.68625737
53DAPK10.68545000
54PASK0.67865451
55GRK70.67853853
56PLK30.67183707
57VRK20.65556479
58LCK0.63985267
59ERBB30.60000238
60PTK2B0.58580548
61MAP3K30.54992118
62RPS6KA50.54853457
63PKN10.54484560
64CSK0.54371612
65MAP3K90.53374726
66FGFR10.52961495
67MAP2K60.52047676
68IGF1R0.51676658
69INSRR0.51506899
70TEC0.51375016
71BCR0.50631448
72LYN0.48121762
73PRKCH0.45410209
74ZAP700.44338768
75NEK10.43486497
76MAPK70.42775365
77STK380.41963913
78DAPK20.41441127
79CDK80.40798697
80MKNK20.38740522
81PRKCE0.36366730
82JAK30.35517536
83ADRBK10.35102161
84CHEK20.34999538
85MKNK10.33670274
86PRKCA0.33367853
87OBSCN0.33160840
88ROCK10.32780586
89PLK10.31536071
90LIMK10.30753296
91MAP2K20.29672206
92CAMK2A0.28778158
93BTK0.28150303
94PRKACA0.26782751
95MAP3K120.26439489
96CSNK2A10.25790793
97MAPK120.25119501
98ATR0.23797914
99PRKCD0.22486744
100PIM10.22461741

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.27150651
2Proteasome_Homo sapiens_hsa030503.62467398
3Graft-versus-host disease_Homo sapiens_hsa053322.94025969
4Antigen processing and presentation_Homo sapiens_hsa046122.85257858
5Allograft rejection_Homo sapiens_hsa053302.47953535
6Autoimmune thyroid disease_Homo sapiens_hsa053202.44368188
7Homologous recombination_Homo sapiens_hsa034402.37209882
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.29510769
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.23275863
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.12469924
11Nitrogen metabolism_Homo sapiens_hsa009102.06569888
12Type I diabetes mellitus_Homo sapiens_hsa049402.06097731
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.86414362
14RNA polymerase_Homo sapiens_hsa030201.86197790
15Protein export_Homo sapiens_hsa030601.85400888
16Arachidonic acid metabolism_Homo sapiens_hsa005901.83882200
17Oxidative phosphorylation_Homo sapiens_hsa001901.82539880
18Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.72768472
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.67428342
20Parkinsons disease_Homo sapiens_hsa050121.64532018
21Butanoate metabolism_Homo sapiens_hsa006501.63159103
22Chemical carcinogenesis_Homo sapiens_hsa052041.55265855
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.48520590
24Linoleic acid metabolism_Homo sapiens_hsa005911.44897598
25Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.43069985
26T cell receptor signaling pathway_Homo sapiens_hsa046601.42845434
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.40449574
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.38944956
29Glutathione metabolism_Homo sapiens_hsa004801.38617063
30Sulfur metabolism_Homo sapiens_hsa009201.32187845
31Basal transcription factors_Homo sapiens_hsa030221.29923819
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.29341737
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28046822
34Rheumatoid arthritis_Homo sapiens_hsa053231.28040242
35Pentose and glucuronate interconversions_Homo sapiens_hsa000401.27355013
36Phototransduction_Homo sapiens_hsa047441.19155834
37Asthma_Homo sapiens_hsa053101.18746899
38Caffeine metabolism_Homo sapiens_hsa002321.17950258
39Tryptophan metabolism_Homo sapiens_hsa003801.17079521
40Hematopoietic cell lineage_Homo sapiens_hsa046401.16808197
41NF-kappa B signaling pathway_Homo sapiens_hsa040641.16053693
42Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.14822324
43Olfactory transduction_Homo sapiens_hsa047401.13752459
44One carbon pool by folate_Homo sapiens_hsa006701.11569751
45Non-homologous end-joining_Homo sapiens_hsa034501.11417421
46Mismatch repair_Homo sapiens_hsa034301.08651433
47Steroid hormone biosynthesis_Homo sapiens_hsa001401.04421150
48Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.02169276
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98259109
50Nucleotide excision repair_Homo sapiens_hsa034200.97149338
51Alzheimers disease_Homo sapiens_hsa050100.94452854
52SNARE interactions in vesicular transport_Homo sapiens_hsa041300.87201831
53Purine metabolism_Homo sapiens_hsa002300.84257639
54Pyrimidine metabolism_Homo sapiens_hsa002400.82885918
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.81989436
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80500583
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80483529
58Huntingtons disease_Homo sapiens_hsa050160.77645793
59Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.76781174
60Regulation of autophagy_Homo sapiens_hsa041400.75599527
61Salmonella infection_Homo sapiens_hsa051320.74893010
62Systemic lupus erythematosus_Homo sapiens_hsa053220.73869131
63Fatty acid elongation_Homo sapiens_hsa000620.73470923
64Propanoate metabolism_Homo sapiens_hsa006400.73250731
65African trypanosomiasis_Homo sapiens_hsa051430.73139990
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73102065
67Retinol metabolism_Homo sapiens_hsa008300.70744454
68Peroxisome_Homo sapiens_hsa041460.67687602
69RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.65476325
70DNA replication_Homo sapiens_hsa030300.65237471
71Fanconi anemia pathway_Homo sapiens_hsa034600.63674123
72Selenocompound metabolism_Homo sapiens_hsa004500.61836661
73Measles_Homo sapiens_hsa051620.59627954
74p53 signaling pathway_Homo sapiens_hsa041150.55856211
75Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.52712554
76Toll-like receptor signaling pathway_Homo sapiens_hsa046200.46639337
77Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46613160
78Cardiac muscle contraction_Homo sapiens_hsa042600.46023978
79ABC transporters_Homo sapiens_hsa020100.45722805
80Taste transduction_Homo sapiens_hsa047420.45362981
81Viral myocarditis_Homo sapiens_hsa054160.44753966
82Mineral absorption_Homo sapiens_hsa049780.44054066
83Base excision repair_Homo sapiens_hsa034100.43889542
84Fatty acid degradation_Homo sapiens_hsa000710.42107575
85Morphine addiction_Homo sapiens_hsa050320.39551928
86Cysteine and methionine metabolism_Homo sapiens_hsa002700.39063203
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.38375815
88Herpes simplex infection_Homo sapiens_hsa051680.37304322
89RNA degradation_Homo sapiens_hsa030180.37292586
90RNA transport_Homo sapiens_hsa030130.37128857
91Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35065756
92Glycerolipid metabolism_Homo sapiens_hsa005610.35026148
93Epstein-Barr virus infection_Homo sapiens_hsa051690.30695200
94Platelet activation_Homo sapiens_hsa046110.30141200
95Metabolic pathways_Homo sapiens_hsa011000.28890627
96Ether lipid metabolism_Homo sapiens_hsa005650.27701362
97Apoptosis_Homo sapiens_hsa042100.25371774
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24663016
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.24334998
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.23972374

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