BUD31

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.45627846
2ATP synthesis coupled proton transport (GO:0015986)5.96939127
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.96939127
4proteasome assembly (GO:0043248)5.90616005
5ribosomal small subunit biogenesis (GO:0042274)5.80676840
6viral transcription (GO:0019083)5.48135988
7translational termination (GO:0006415)5.37973948
8maturation of SSU-rRNA (GO:0030490)5.20994429
9cotranslational protein targeting to membrane (GO:0006613)5.04029654
10SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.01711967
11protein targeting to ER (GO:0045047)4.96682172
12negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.92749734
13ribosomal small subunit assembly (GO:0000028)4.83212434
14establishment of protein localization to endoplasmic reticulum (GO:0072599)4.74877701
15protein localization to endoplasmic reticulum (GO:0070972)4.73296408
16positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.65532393
17negative regulation of ligase activity (GO:0051352)4.60107730
18negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.60107730
19regulation of cellular amino acid metabolic process (GO:0006521)4.56423284
20translational elongation (GO:0006414)4.51985143
21translational initiation (GO:0006413)4.50979018
22regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.47500631
23mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.47317875
24protein neddylation (GO:0045116)4.41151112
25transcription elongation from RNA polymerase III promoter (GO:0006385)4.40021507
26termination of RNA polymerase III transcription (GO:0006386)4.40021507
27ribosomal large subunit biogenesis (GO:0042273)4.39134965
28chaperone-mediated protein transport (GO:0072321)4.37213916
29DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.36574688
30anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.35148919
31antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:4.33235275
327-methylguanosine mRNA capping (GO:0006370)4.32879667
33RNA capping (GO:0036260)4.29757834
347-methylguanosine RNA capping (GO:0009452)4.29757834
35cellular protein complex disassembly (GO:0043624)4.29244106
36intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.28360824
37signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.28360824
38viral life cycle (GO:0019058)4.27608542
39signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.23597410
40signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.23597410
41signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.23597410
42establishment of protein localization to mitochondrial membrane (GO:0090151)4.22589110
43translation (GO:0006412)4.22340703
44establishment of integrated proviral latency (GO:0075713)4.19829647
45signal transduction involved in DNA integrity checkpoint (GO:0072401)4.15541727
46signal transduction involved in DNA damage checkpoint (GO:0072422)4.15541727
47inner mitochondrial membrane organization (GO:0007007)4.14375814
48signal transduction involved in cell cycle checkpoint (GO:0072395)4.10365539
49nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.09914422
50antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)4.07153193
51sequestering of actin monomers (GO:0042989)4.06441606
52respiratory electron transport chain (GO:0022904)4.05393071
53positive regulation of ubiquitin-protein transferase activity (GO:0051443)4.00821833
54electron transport chain (GO:0022900)3.95961701
55regulation of mitochondrial translation (GO:0070129)3.91800980
56cullin deneddylation (GO:0010388)3.89703346
57positive regulation of ligase activity (GO:0051351)3.86945128
58formation of translation preinitiation complex (GO:0001731)3.84915795
59establishment of viral latency (GO:0019043)3.80580374
60L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.78186631
61ribonucleoprotein complex biogenesis (GO:0022613)3.76851605
62ATP biosynthetic process (GO:0006754)3.76441895
63protein deneddylation (GO:0000338)3.76331541
64hydrogen ion transmembrane transport (GO:1902600)3.68013334
65purine nucleoside triphosphate biosynthetic process (GO:0009145)3.67124671
66purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.64595514
67transcription elongation from RNA polymerase I promoter (GO:0006362)3.63366838
68spliceosomal snRNP assembly (GO:0000387)3.60821195
69mitochondrial respiratory chain complex I assembly (GO:0032981)3.60560851
70NADH dehydrogenase complex assembly (GO:0010257)3.60560851
71mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.60560851
72protein complex disassembly (GO:0043241)3.58981488
73GTP biosynthetic process (GO:0006183)3.58943049
74regulation of ubiquitin-protein transferase activity (GO:0051438)3.55960311
75spliceosomal complex assembly (GO:0000245)3.55779941
76rRNA processing (GO:0006364)3.50565281
77rRNA modification (GO:0000154)3.49618026
78establishment of protein localization to mitochondrion (GO:0072655)3.47971337
79regulation of cellular amine metabolic process (GO:0033238)3.47860743
80protein targeting to mitochondrion (GO:0006626)3.46730227
81regulation of ligase activity (GO:0051340)3.46294313
82protein-cofactor linkage (GO:0018065)3.43095730
83termination of RNA polymerase I transcription (GO:0006363)3.42192720
84macromolecular complex disassembly (GO:0032984)3.41923933
85DNA deamination (GO:0045006)3.40010840
86cellular component biogenesis (GO:0044085)3.39715088
87nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.36422804
88protein targeting to membrane (GO:0006612)3.35323433
89rRNA metabolic process (GO:0016072)3.33571115
90ribosome assembly (GO:0042255)3.31400340
91positive regulation of cell cycle arrest (GO:0071158)3.31001578
92ribonucleoside triphosphate biosynthetic process (GO:0009201)3.30118502
93antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.29083721
94DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.28909439
95exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.28141468
96intracellular protein transmembrane import (GO:0044743)3.27902541
97protein complex biogenesis (GO:0070271)3.27513832
98proton transport (GO:0015992)3.25474333
99transcription-coupled nucleotide-excision repair (GO:0006283)3.25139122
100oxidative phosphorylation (GO:0006119)3.23451612
101transcription from RNA polymerase I promoter (GO:0006360)3.22949155
102protein localization to mitochondrion (GO:0070585)3.21747223
103pseudouridine synthesis (GO:0001522)3.21718448
104UTP biosynthetic process (GO:0006228)3.21121236
105L-methionine biosynthetic process (GO:0071265)3.19832252
106amino acid salvage (GO:0043102)3.19832252
107L-methionine salvage (GO:0071267)3.19832252
108DNA damage response, detection of DNA damage (GO:0042769)3.19303352
109transcription elongation from RNA polymerase II promoter (GO:0006368)3.17601584
110hydrogen transport (GO:0006818)3.16934859
111mitochondrial transport (GO:0006839)3.15043840
112nuclear-transcribed mRNA catabolic process (GO:0000956)3.13930385
113respiratory chain complex IV assembly (GO:0008535)3.11919873
114nucleoside triphosphate biosynthetic process (GO:0009142)3.11700081
115mitochondrial respiratory chain complex assembly (GO:0033108)3.10431014
116guanosine-containing compound biosynthetic process (GO:1901070)3.08549712
117tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.06397805
118RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.06397805
119positive regulation of viral transcription (GO:0050434)3.05613884

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.06133783
2* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.94017459
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.87487456
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.45124257
5MYC_18555785_ChIP-Seq_MESCs_Mouse4.27728361
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.95015679
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.93204650
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.90658821
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.86769875
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.77884609
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.59311291
12* CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.33374760
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.25960925
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.13295184
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.99248740
16* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.96781438
17E2F7_22180533_ChIP-Seq_HELA_Human2.94484732
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.79011991
19* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.77458942
20* VDR_23849224_ChIP-Seq_CD4+_Human2.71225568
21DCP1A_22483619_ChIP-Seq_HELA_Human2.52077997
22ELK1_19687146_ChIP-ChIP_HELA_Human2.49832960
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.49710461
24XRN2_22483619_ChIP-Seq_HELA_Human2.46199962
25* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.38067184
26NELFA_20434984_ChIP-Seq_ESCs_Mouse2.27528616
27E2F4_17652178_ChIP-ChIP_JURKAT_Human2.26504223
28PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.25931405
29* SRF_21415370_ChIP-Seq_HL-1_Mouse2.12460547
30FOXP3_21729870_ChIP-Seq_TREG_Human2.12337266
31THAP11_20581084_ChIP-Seq_MESCs_Mouse2.06988176
32FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.06819087
33GABP_19822575_ChIP-Seq_HepG2_Human2.04941312
34HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.04235308
35TTF2_22483619_ChIP-Seq_HELA_Human2.02988098
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.86019611
37* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.84115081
38ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.77520507
39YY1_21170310_ChIP-Seq_MESCs_Mouse1.76933068
40* ELK1_22589737_ChIP-Seq_MCF10A_Human1.76392296
41FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.74229574
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.73847029
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.70726310
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.66096397
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.63092520
46* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.61172961
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58171287
48* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.57784415
49AR_21909140_ChIP-Seq_LNCAP_Human1.47599969
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.41790289
51YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38700373
52PADI4_21655091_ChIP-ChIP_MCF-7_Human1.37225329
53NANOG_18555785_ChIP-Seq_MESCs_Mouse1.36429152
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.36369112
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.34646613
56MYC_18940864_ChIP-ChIP_HL60_Human1.31860544
57ERG_20887958_ChIP-Seq_HPC-7_Mouse1.31629757
58FOXM1_23109430_ChIP-Seq_U2OS_Human1.31137659
59TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.27315615
60* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.21977088
61POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21948691
62CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.20349261
63ZNF274_21170338_ChIP-Seq_K562_Hela1.19703835
64SOX17_20123909_ChIP-Seq_XEN_Mouse1.19480893
65IRF1_19129219_ChIP-ChIP_H3396_Human1.16408876
66BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.10182439
67CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08691444
68KDM5A_27292631_Chip-Seq_BREAST_Human1.06719102
69NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.04481303
70* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04235682
71CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00149784
72SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.99925578
73SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96803692
74HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.93990595
75SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.93428239
76* CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.91223938
77E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89967095
78TFEB_21752829_ChIP-Seq_HELA_Human0.88893980
79* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.86674516
80ZNF263_19887448_ChIP-Seq_K562_Human0.86439477
81* CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.85867406
82HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.85368670
83TP53_22573176_ChIP-Seq_HFKS_Human0.85083770
84DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.84808437
85E2F1_21310950_ChIP-Seq_MCF-7_Human0.84037290
86CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.83828511
87SPI1_23547873_ChIP-Seq_NB4_Human0.83771599
88ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.83729052
89MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.83582495
90TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83349086
91* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82985291
92NOTCH1_21737748_ChIP-Seq_TLL_Human0.82163084
93NANOG_16153702_ChIP-ChIP_HESCs_Human0.81158034
94SRY_22984422_ChIP-ChIP_TESTIS_Rat0.80241862
95OCT4_18692474_ChIP-Seq_MEFs_Mouse0.79760198
96FOXP1_21924763_ChIP-Seq_HESCs_Human0.77104433
97SOX2_18692474_ChIP-Seq_MEFs_Mouse0.77072483
98EWS_26573619_Chip-Seq_HEK293_Human0.77003961
99GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.76399700
100KLF4_18555785_ChIP-Seq_MESCs_Mouse0.75906556
101CTCF_18555785_ChIP-Seq_MESCs_Mouse0.74769475
102SOX2_18555785_ChIP-Seq_MESCs_Mouse0.73996918
103CIITA_25753668_ChIP-Seq_RAJI_Human0.73515719
104POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.71819710
105VDR_22108803_ChIP-Seq_LS180_Human0.71166414
106ERG_20517297_ChIP-Seq_VCAP_Human0.68142295
107SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.67694921
108SOX2_16153702_ChIP-ChIP_HESCs_Human0.67631896
109SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.67547070
110* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.65453776
111ELF5_23300383_ChIP-Seq_T47D_Human0.65422389
112DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.64508121
113POU5F1_16153702_ChIP-ChIP_HESCs_Human0.64060570
114TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.63876904
115PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.63803985

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.27183730
2MP0004957_abnormal_blastocyst_morpholog3.96505122
3MP0009379_abnormal_foot_pigmentation3.86667418
4MP0003806_abnormal_nucleotide_metabolis3.35468943
5MP0001529_abnormal_vocalization3.33433327
6MP0008932_abnormal_embryonic_tissue3.10452970
7MP0003718_maternal_effect3.07330645
8MP0003077_abnormal_cell_cycle2.97190139
9MP0001905_abnormal_dopamine_level2.69419180
10MP0005408_hypopigmentation2.64340530
11MP0003186_abnormal_redox_activity2.54648740
12MP0008057_abnormal_DNA_replication2.54382528
13MP0010094_abnormal_chromosome_stability2.45830951
14MP0003111_abnormal_nucleus_morphology2.34871076
15MP0008058_abnormal_DNA_repair2.14824901
16MP0003136_yellow_coat_color2.11382657
17MP0009333_abnormal_splenocyte_physiolog2.07037254
18MP0001727_abnormal_embryo_implantation1.94730226
19MP0002653_abnormal_ependyma_morphology1.90946021
20MP0006036_abnormal_mitochondrial_physio1.86916017
21MP0004147_increased_porphyrin_level1.81681555
22MP0002736_abnormal_nociception_after1.79548723
23MP0010030_abnormal_orbit_morphology1.78345928
24MP0000920_abnormal_myelination1.77908319
25MP0001730_embryonic_growth_arrest1.70918442
26MP0008995_early_reproductive_senescence1.69650205
27MP0002938_white_spotting1.69582686
28MP0003123_paternal_imprinting1.66923621
29MP0003786_premature_aging1.66691554
30MP0001293_anophthalmia1.59634057
31MP0006035_abnormal_mitochondrial_morpho1.59041156
32MP0003315_abnormal_perineum_morphology1.56599423
33MP0001542_abnormal_bone_strength1.53684013
34MP0005423_abnormal_somatic_nervous1.52917282
35MP0002102_abnormal_ear_morphology1.47663479
36MP0005394_taste/olfaction_phenotype1.47625198
37MP0005499_abnormal_olfactory_system1.47625198
38MP0009697_abnormal_copulation1.39802652
39MP0008007_abnormal_cellular_replicative1.39591537
40MP0003656_abnormal_erythrocyte_physiolo1.30604197
41MP0002638_abnormal_pupillary_reflex1.29376790
42MP0005253_abnormal_eye_physiology1.29053599
43MP0001984_abnormal_olfaction1.26544961
44MP0008875_abnormal_xenobiotic_pharmacok1.26049185
45MP0009046_muscle_twitch1.25209072
46MP0002837_dystrophic_cardiac_calcinosis1.24705296
47MP0001661_extended_life_span1.23730355
48MP0003950_abnormal_plasma_membrane1.22734680
49MP0005451_abnormal_body_composition1.22475499
50MP0000358_abnormal_cell_content/1.22324708
51MP0000372_irregular_coat_pigmentation1.19969537
52MP0003880_abnormal_central_pattern1.18023042
53MP0006054_spinal_hemorrhage1.17243070
54MP0000350_abnormal_cell_proliferation1.17234773
55MP0004142_abnormal_muscle_tone1.15809725
56MP0005410_abnormal_fertilization1.15393767
57MP0002163_abnormal_gland_morphology1.13103741
58MP0002095_abnormal_skin_pigmentation1.12426099
59MP0000647_abnormal_sebaceous_gland1.11498821
60MP0001968_abnormal_touch/_nociception1.11469011
61MP0005379_endocrine/exocrine_gland_phen1.09217988
62MP0004134_abnormal_chest_morphology1.08628258
63MP0000049_abnormal_middle_ear1.07989304
64MP0003011_delayed_dark_adaptation1.05661532
65MP0000462_abnormal_digestive_system1.05043581
66MP0003121_genomic_imprinting1.03608150
67MP0002090_abnormal_vision1.03274011
68MP0005551_abnormal_eye_electrophysiolog1.02892614
69MP0000313_abnormal_cell_death1.02823219
70MP0000631_abnormal_neuroendocrine_gland1.02815078
71MP0002822_catalepsy1.01278929
72MP0003937_abnormal_limbs/digits/tail_de1.00541316
73MP0001919_abnormal_reproductive_system1.00185818
74MP0001697_abnormal_embryo_size0.98821664
75MP0003221_abnormal_cardiomyocyte_apopto0.98783621
76MP0006082_CNS_inflammation0.98518242
77MP0009785_altered_susceptibility_to0.96747438
78MP0008872_abnormal_physiological_respon0.96740101
79MP0002080_prenatal_lethality0.96089664
80MP0008260_abnormal_autophagy0.96047494
81MP0005171_absent_coat_pigmentation0.95053301
82MP0005395_other_phenotype0.94988566
83MP0002234_abnormal_pharynx_morphology0.94119544
84MP0008789_abnormal_olfactory_epithelium0.93702514
85MP0004742_abnormal_vestibular_system0.93082865
86MP0005084_abnormal_gallbladder_morpholo0.91561204
87MP0005645_abnormal_hypothalamus_physiol0.91055530
88MP0001485_abnormal_pinna_reflex0.89681101
89MP0005391_vision/eye_phenotype0.87204342
90MP0002210_abnormal_sex_determination0.87007275
91MP0001929_abnormal_gametogenesis0.86936365
92MP0002295_abnormal_pulmonary_circulatio0.86041046
93MP0005389_reproductive_system_phenotype0.85628705
94MP0002272_abnormal_nervous_system0.84996128
95MP0002160_abnormal_reproductive_system0.84816927
96MP0002148_abnormal_hypersensitivity_rea0.84790412
97MP0002019_abnormal_tumor_incidence0.83779170
98MP0005636_abnormal_mineral_homeostasis0.82274906
99MP0001145_abnormal_male_reproductive0.81833971
100MP0005195_abnormal_posterior_eye0.81196148
101MP0002751_abnormal_autonomic_nervous0.81112132
102MP0003938_abnormal_ear_development0.80523160
103MP0005164_abnormal_response_to0.79283542
104MP0006276_abnormal_autonomic_nervous0.78490835
105MP0005075_abnormal_melanosome_morpholog0.78111503
106MP0009745_abnormal_behavioral_response0.77383362
107MP0000026_abnormal_inner_ear0.75169010
108MP0001286_abnormal_eye_development0.74855946
109MP0001764_abnormal_homeostasis0.73884971
110MP0000750_abnormal_muscle_regeneration0.73815523
111MP0002697_abnormal_eye_size0.73184971
112MP0001986_abnormal_taste_sensitivity0.73176157
113MP0003698_abnormal_male_reproductive0.72733023
114MP0005380_embryogenesis_phenotype0.72702689
115MP0001672_abnormal_embryogenesis/_devel0.72702689
116MP0005000_abnormal_immune_tolerance0.71653790
117MP0002752_abnormal_somatic_nervous0.71239339
118MP0000778_abnormal_nervous_system0.70613200
119MP0002233_abnormal_nose_morphology0.69431423
120MP0001853_heart_inflammation0.69292340
121MP0002085_abnormal_embryonic_tissue0.68657098
122MP0002132_abnormal_respiratory_system0.68024627
123MP0002282_abnormal_trachea_morphology0.67563986
124MP0005376_homeostasis/metabolism_phenot0.66918575
125MP0005409_darkened_coat_color0.66827641
126MP0000653_abnormal_sex_gland0.66489116
127MP0001324_abnormal_eye_pigmentation0.66159275
128MP0006072_abnormal_retinal_apoptosis0.65135897
129MP0005266_abnormal_metabolism0.64910325
130MP0000689_abnormal_spleen_morphology0.64447456
131MP0000490_abnormal_crypts_of0.64433626
132MP0004133_heterotaxia0.63797692
133MP0002277_abnormal_respiratory_mucosa0.62044870
134MP0002429_abnormal_blood_cell0.61186977
135MP0002722_abnormal_immune_system0.61173562
136MP0006292_abnormal_olfactory_placode0.60816223
137MP0000537_abnormal_urethra_morphology0.60698425
138MP0008877_abnormal_DNA_methylation0.60527077
139MP0005671_abnormal_response_to0.60189386
140MP0003984_embryonic_growth_retardation0.58757441
141MP0003724_increased_susceptibility_to0.56851924

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.12147756
2Abnormal mitochondria in muscle tissue (HP:0008316)5.32050377
3Mitochondrial inheritance (HP:0001427)5.19109686
4Acute encephalopathy (HP:0006846)5.02563571
5Progressive macrocephaly (HP:0004481)4.91030133
6Increased hepatocellular lipid droplets (HP:0006565)4.88904985
7Abnormality of cells of the erythroid lineage (HP:0012130)4.85922449
8Abnormality of glycolysis (HP:0004366)4.50647951
9Increased serum pyruvate (HP:0003542)4.50647951
10Increased CSF lactate (HP:0002490)4.46140224
11Abnormal number of erythroid precursors (HP:0012131)4.36057332
12Lipid accumulation in hepatocytes (HP:0006561)4.33810443
13Hepatocellular necrosis (HP:0001404)4.17188908
14Cerebral hypomyelination (HP:0006808)4.17151688
15Renal Fanconi syndrome (HP:0001994)4.13512431
16Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.12486819
173-Methylglutaconic aciduria (HP:0003535)3.99633836
18Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.94214296
19Reticulocytopenia (HP:0001896)3.85505216
20Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.78477674
21Macrocytic anemia (HP:0001972)3.75513169
22Breast hypoplasia (HP:0003187)3.65145665
23Hepatic necrosis (HP:0002605)3.61564740
24Parakeratosis (HP:0001036)3.59168838
25Birth length less than 3rd percentile (HP:0003561)3.58345621
26Exertional dyspnea (HP:0002875)3.45004581
27Leukodystrophy (HP:0002415)3.43983313
28Cerebral edema (HP:0002181)3.42140146
29Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.22264658
30Decreased activity of mitochondrial respiratory chain (HP:0008972)3.22264658
31Increased intramyocellular lipid droplets (HP:0012240)3.19234606
32Increased serum lactate (HP:0002151)3.18748190
33Respiratory failure (HP:0002878)3.16844248
34Exercise intolerance (HP:0003546)3.10610639
35Pallor (HP:0000980)2.89412299
36Congenital ichthyosiform erythroderma (HP:0007431)2.88613859
37Respiratory difficulties (HP:0002880)2.81158000
38Optic disc pallor (HP:0000543)2.80933032
39Small epiphyses (HP:0010585)2.76485568
40Lactic acidosis (HP:0003128)2.75175488
41Carpal bone hypoplasia (HP:0001498)2.69662820
42Secondary amenorrhea (HP:0000869)2.64634615
43Abnormality of renal resorption (HP:0011038)2.63956402
44Microvesicular hepatic steatosis (HP:0001414)2.62470727
45Abnormality of the anterior horn cell (HP:0006802)2.58883485
46Degeneration of anterior horn cells (HP:0002398)2.58883485
47Increased muscle lipid content (HP:0009058)2.57907338
48Multiple enchondromatosis (HP:0005701)2.56603310
49Irregular epiphyses (HP:0010582)2.54657499
50Rough bone trabeculation (HP:0100670)2.53289983
51CNS hypomyelination (HP:0003429)2.50810066
52Medial flaring of the eyebrow (HP:0010747)2.50506269
53CNS demyelination (HP:0007305)2.45547968
54Delusions (HP:0000746)2.41417872
55Aplasia/Hypoplasia of the sacrum (HP:0008517)2.41029150
56Molar tooth sign on MRI (HP:0002419)2.40799845
57Abnormality of midbrain morphology (HP:0002418)2.40799845
58Generalized aminoaciduria (HP:0002909)2.32850860
59Pancreatic cysts (HP:0001737)2.31034512
60Postnatal microcephaly (HP:0005484)2.27296147
61Oral leukoplakia (HP:0002745)2.27001697
62Methylmalonic acidemia (HP:0002912)2.26917135
63Abnormality of the heme biosynthetic pathway (HP:0010472)2.25864887
64Pancreatic fibrosis (HP:0100732)2.25802672
65Abnormality of alanine metabolism (HP:0010916)2.25663673
66Hyperalaninemia (HP:0003348)2.25663673
67Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.25663673
68Methylmalonic aciduria (HP:0012120)2.23418047
69Emotional lability (HP:0000712)2.22228374
70Spastic paraparesis (HP:0002313)2.15803545
71Glossoptosis (HP:0000162)2.13993229
72Adrenal hypoplasia (HP:0000835)2.13723322
73True hermaphroditism (HP:0010459)2.11994318
74Glycosuria (HP:0003076)2.11848134
75Abnormality of urine glucose concentration (HP:0011016)2.11848134
76Pancytopenia (HP:0001876)2.08961354
77Hyperphosphaturia (HP:0003109)2.07621636
78Hypoplasia of the capital femoral epiphysis (HP:0003090)2.05921856
79Concave nail (HP:0001598)2.05794051
80Abnormality of placental membranes (HP:0011409)2.04901869
81Amniotic constriction ring (HP:0009775)2.04901869
82Aplastic anemia (HP:0001915)2.02935023
83Congenital primary aphakia (HP:0007707)2.00229508
84Gait imbalance (HP:0002141)2.00031421
85Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.99915725
86Absent epiphyses (HP:0010577)1.99915725
87Poor head control (HP:0002421)1.98536379
88Trismus (HP:0000211)1.98531863
89Abnormal trabecular bone morphology (HP:0100671)1.97763697
90Sensory axonal neuropathy (HP:0003390)1.96944395
91Abnormality of the pons (HP:0007361)1.96820709
92Type I transferrin isoform profile (HP:0003642)1.96518979
93Nephrogenic diabetes insipidus (HP:0009806)1.93897276
94Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.93226639
95Blindness (HP:0000618)1.93026199
96Testicular atrophy (HP:0000029)1.92802433
97Abnormal ciliary motility (HP:0012262)1.92052415
98Lethargy (HP:0001254)1.91720798
99Abnormal pupillary function (HP:0007686)1.91696739
100Abnormal respiratory motile cilium physiology (HP:0012261)1.91478338
101Hypoplasia of the pons (HP:0012110)1.91356143
102Stenosis of the external auditory canal (HP:0000402)1.89677515
103Aplasia/hypoplasia of the uterus (HP:0008684)1.87595462
104Sclerocornea (HP:0000647)1.86673135
105Hepatosplenomegaly (HP:0001433)1.84802875
106Hyperglycinemia (HP:0002154)1.84710752
107Premature graying of hair (HP:0002216)1.83397617
108Seborrheic dermatitis (HP:0001051)1.79953516
109Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.79580785
110Nephronophthisis (HP:0000090)1.79531566
111X-linked dominant inheritance (HP:0001423)1.75435796
112Autoamputation (HP:0001218)1.74048263
113Microretrognathia (HP:0000308)1.72530457
114Abnormal hemoglobin (HP:0011902)1.72343109
115Hypoplastic pelvis (HP:0008839)1.72315693
116Abnormal autonomic nervous system physiology (HP:0012332)1.71027580
117Premature ovarian failure (HP:0008209)1.70803087
118Abnormal respiratory motile cilium morphology (HP:0005938)1.70005829
119Abnormal respiratory epithelium morphology (HP:0012253)1.70005829
120Aplasia/Hypoplasia involving the musculature (HP:0001460)1.68350050
121Abnormality of the umbilical cord (HP:0010881)1.67560469
122Sparse eyelashes (HP:0000653)1.66735986
123Absent thumb (HP:0009777)1.66196443
124Abnormal protein N-linked glycosylation (HP:0012347)1.64647448
125Abnormal protein glycosylation (HP:0012346)1.64647448
126Abnormal glycosylation (HP:0012345)1.64647448
127Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.64647448
128Abnormality of dicarboxylic acid metabolism (HP:0010995)1.64156251
129Dicarboxylic aciduria (HP:0003215)1.64156251
130Abnormal urine phosphate concentration (HP:0012599)1.63365695
131Abnormality of the fetal cardiovascular system (HP:0010948)1.62985080
132Abnormal umbilical cord blood vessels (HP:0011403)1.62985080
133Single umbilical artery (HP:0001195)1.62985080
134Abnormality of the labia minora (HP:0012880)1.62881696
135Congenital, generalized hypertrichosis (HP:0004540)1.62086628
136Irregular vertebral endplates (HP:0003301)1.61918174
137Erythroderma (HP:0001019)1.61732755
138Abnormality of serum amino acid levels (HP:0003112)1.61383592
139Colon cancer (HP:0003003)1.60463292
140Gliosis (HP:0002171)1.59592392
141Rhinitis (HP:0012384)1.59489040
142Upper limb muscle weakness (HP:0003484)1.58492620
143Poor suck (HP:0002033)1.58440819

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.12964474
2BUB14.67587731
3NME23.68657414
4STK163.35351288
5WEE13.12166738
6PBK2.96973597
7EIF2AK12.87318490
8TESK22.75040915
9EIF2AK32.67776885
10SRPK12.54746729
11STK392.43810161
12MAP3K122.43430436
13NME12.39021785
14VRK12.32548058
15MST42.21683805
16NEK12.18252007
17LIMK12.10336851
18TLK11.90657301
19PLK41.84515848
20ARAF1.80926621
21PIM21.75112532
22DYRK21.71088422
23ACVR1B1.70994319
24KDR1.69502345
25PNCK1.61284318
26MAP4K21.56484594
27DYRK31.48930471
28TRIM281.43163939
29TESK11.39718813
30MKNK11.39370452
31BCR1.32526004
32BRSK21.32267664
33OXSR11.28369375
34ABL21.27066723
35MAP2K71.24958225
36CDC71.23424855
37EPHB21.17330990
38NUAK11.13668734
39AURKA1.13105638
40WNK41.09852271
41CSNK1G31.04501908
42TSSK61.03813948
43PLK31.03397005
44BRAF1.02466512
45EPHA21.02390072
46TXK0.98366386
47TNIK0.98232925
48PLK10.97384770
49RPS6KA50.94955345
50CDK190.93065014
51BMPR1B0.88183873
52PAK10.87432079
53AURKB0.86758946
54MAPKAPK50.83926952
55GRK10.83885419
56TAF10.82354448
57FGR0.80056841
58BLK0.78723727
59DAPK30.78270871
60RPS6KB20.78007731
61MKNK20.75396413
62MAP3K40.74161509
63LRRK20.72338958
64TTK0.71693329
65BRSK10.71625000
66CSNK2A10.70863307
67CSNK2A20.70463157
68MUSK0.68780621
69CSNK1G10.65928170
70ERBB30.64789370
71ATR0.63750075
72MET0.63732204
73PASK0.63232281
74CDK80.61367648
75PINK10.61210678
76PRKCG0.60416617
77CDK70.58616118
78UHMK10.57704953
79GRK70.57265923
80MAP3K80.57240346
81NEK20.56292999
82ILK0.55997267
83CSNK1A1L0.55652383
84MAPK150.54252927
85CDK140.53961994
86MYLK0.52581958
87DAPK10.50787499
88RPS6KA40.49971865
89MAP3K30.49845042
90CHEK20.49605731
91PLK20.49266522
92SCYL20.49220944
93IRAK40.48692471
94ZAK0.47560239
95EIF2AK20.46986559
96STK40.46880546
97TAOK20.44672007
98MINK10.44556695
99WNK30.44342029
100STK100.43826033
101CAMK2B0.42135431
102MAP3K110.41706196
103BCKDK0.40917388
104CASK0.40659756
105ADRBK20.40164240
106CDK11A0.40144061
107IRAK30.39966323
108CSNK1G20.38745264
109YES10.38660463
110MAPKAPK30.37815365
111CDK150.37768734
112INSRR0.37548262
113PAK40.36962583
114LYN0.36890781
115CDK180.36770194
116PDK20.36071269
117MOS0.35529332
118CCNB10.35507008
119ERBB40.35291047
120CHEK10.33971870
121CSNK1E0.33731966
122CAMK2G0.33618093
123ROCK20.32795422
124PRKCI0.32538028
125TGFBR10.32183105
126MELK0.31964326
127PKN10.30938926
128FES0.30232603

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.50116551
2Ribosome_Homo sapiens_hsa030104.92893887
3RNA polymerase_Homo sapiens_hsa030204.02688057
4Oxidative phosphorylation_Homo sapiens_hsa001903.87058001
5Parkinsons disease_Homo sapiens_hsa050123.26979509
6Protein export_Homo sapiens_hsa030603.18847353
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.67511887
8* Spliceosome_Homo sapiens_hsa030402.55932741
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.53776520
10Huntingtons disease_Homo sapiens_hsa050162.49714486
11DNA replication_Homo sapiens_hsa030302.45992727
12Pyrimidine metabolism_Homo sapiens_hsa002402.31765225
13Alzheimers disease_Homo sapiens_hsa050102.29178628
14Nucleotide excision repair_Homo sapiens_hsa034202.06241416
15Mismatch repair_Homo sapiens_hsa034302.05836838
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.04640313
17Basal transcription factors_Homo sapiens_hsa030221.98488991
18RNA transport_Homo sapiens_hsa030131.96643602
19Homologous recombination_Homo sapiens_hsa034401.83583900
20Steroid biosynthesis_Homo sapiens_hsa001001.64761543
21Base excision repair_Homo sapiens_hsa034101.43666306
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.32818343
23Fatty acid elongation_Homo sapiens_hsa000621.27661657
24RNA degradation_Homo sapiens_hsa030181.27264553
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.25153150
26Purine metabolism_Homo sapiens_hsa002301.19707989
27Cell cycle_Homo sapiens_hsa041101.18186611
28Folate biosynthesis_Homo sapiens_hsa007901.17994501
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.17168321
30Non-homologous end-joining_Homo sapiens_hsa034501.15986343
31Glutathione metabolism_Homo sapiens_hsa004801.15791912
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.15622622
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.07556443
34Vitamin B6 metabolism_Homo sapiens_hsa007501.03124731
35Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.03006812
36Epstein-Barr virus infection_Homo sapiens_hsa051690.98452664
37Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.96668956
38Selenocompound metabolism_Homo sapiens_hsa004500.89431676
39Fanconi anemia pathway_Homo sapiens_hsa034600.88530239
40Ether lipid metabolism_Homo sapiens_hsa005650.87718691
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87306951
42Systemic lupus erythematosus_Homo sapiens_hsa053220.85117797
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85008878
44Cardiac muscle contraction_Homo sapiens_hsa042600.80229502
45Metabolic pathways_Homo sapiens_hsa011000.72097470
46Sulfur metabolism_Homo sapiens_hsa009200.70679066
47One carbon pool by folate_Homo sapiens_hsa006700.70654579
48Vibrio cholerae infection_Homo sapiens_hsa051100.70571958
49Propanoate metabolism_Homo sapiens_hsa006400.68449560
50SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66092093
51p53 signaling pathway_Homo sapiens_hsa041150.64184710
52Pentose phosphate pathway_Homo sapiens_hsa000300.63523181
53Collecting duct acid secretion_Homo sapiens_hsa049660.63407774
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.63173385
55Arginine and proline metabolism_Homo sapiens_hsa003300.59511091
56Sphingolipid metabolism_Homo sapiens_hsa006000.59117164
57Sulfur relay system_Homo sapiens_hsa041220.58254985
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.57994030
59Nitrogen metabolism_Homo sapiens_hsa009100.57739986
60Phototransduction_Homo sapiens_hsa047440.57522056
61mRNA surveillance pathway_Homo sapiens_hsa030150.57316945
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55128474
63Rheumatoid arthritis_Homo sapiens_hsa053230.54203730
64Arachidonic acid metabolism_Homo sapiens_hsa005900.52611403
65Butanoate metabolism_Homo sapiens_hsa006500.51067001
66Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50555492
67Graft-versus-host disease_Homo sapiens_hsa053320.50532222
682-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.49215400
69Phagosome_Homo sapiens_hsa041450.47947602
70Linoleic acid metabolism_Homo sapiens_hsa005910.45033142
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.42837547
72Regulation of autophagy_Homo sapiens_hsa041400.42669617
73Antigen processing and presentation_Homo sapiens_hsa046120.42163968
74Synaptic vesicle cycle_Homo sapiens_hsa047210.41860793
75Shigellosis_Homo sapiens_hsa051310.37892002
76Viral carcinogenesis_Homo sapiens_hsa052030.35132358
77Asthma_Homo sapiens_hsa053100.33975626
78Oocyte meiosis_Homo sapiens_hsa041140.33646686
79Alcoholism_Homo sapiens_hsa050340.32747954
80Tyrosine metabolism_Homo sapiens_hsa003500.32578518
81Autoimmune thyroid disease_Homo sapiens_hsa053200.31994623
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.31327624
83N-Glycan biosynthesis_Homo sapiens_hsa005100.30138828
84Allograft rejection_Homo sapiens_hsa053300.30091201
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.29019921
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.28879377
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24743786
88Tryptophan metabolism_Homo sapiens_hsa003800.23689383
89Malaria_Homo sapiens_hsa051440.23535063
90Phenylalanine metabolism_Homo sapiens_hsa003600.22695502
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.22326039
92Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.22102646
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.21615087
94alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21386690
95Pyruvate metabolism_Homo sapiens_hsa006200.21353211
96Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.20608435
97Carbon metabolism_Homo sapiens_hsa012000.20347584
98Fructose and mannose metabolism_Homo sapiens_hsa000510.19629078
99Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.19584252
100Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.19557476
101Primary immunodeficiency_Homo sapiens_hsa053400.19267257
102Nicotine addiction_Homo sapiens_hsa050330.18990893
103Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.17887320
104Peroxisome_Homo sapiens_hsa041460.17385110
105beta-Alanine metabolism_Homo sapiens_hsa004100.17035399
106Biosynthesis of amino acids_Homo sapiens_hsa012300.16148003
107Other glycan degradation_Homo sapiens_hsa005110.15862407
108Hematopoietic cell lineage_Homo sapiens_hsa046400.15217582
109Histidine metabolism_Homo sapiens_hsa003400.14857350
110Legionellosis_Homo sapiens_hsa051340.14851719
111Primary bile acid biosynthesis_Homo sapiens_hsa001200.14178251
112Pentose and glucuronate interconversions_Homo sapiens_hsa000400.13124959
113Basal cell carcinoma_Homo sapiens_hsa052170.12931715
114Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.12694775
115Chemical carcinogenesis_Homo sapiens_hsa052040.11170936
116Herpes simplex infection_Homo sapiens_hsa051680.10214352
117Caffeine metabolism_Homo sapiens_hsa002320.09861390
118Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.08567469
119Hedgehog signaling pathway_Homo sapiens_hsa043400.07120934
120Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.07054226
121Maturity onset diabetes of the young_Homo sapiens_hsa049500.06775865
122TGF-beta signaling pathway_Homo sapiens_hsa043500.05325146
123Vitamin digestion and absorption_Homo sapiens_hsa049770.04882326
124Renal cell carcinoma_Homo sapiens_hsa052110.03744425

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »