ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	rRNA catabolic process (GO:0016075)	4.59342418
2	proteasome assembly (GO:0043248)	4.45937207
3	DNA deamination (GO:0045006)	4.30491022
4	positive regulation of response to tumor cell (GO:0002836)	4.16256936
5	positive regulation of immune response to tumor cell (GO:0002839)	4.16256936
6	regulation of immune response to tumor cell (GO:0002837)	4.16256936
7	regulation of response to tumor cell (GO:0002834)	4.16256936
8	regulation of meiosis I (GO:0060631)	4.15204370
9	cullin deneddylation (GO:0010388)	4.09891867
10	protein deneddylation (GO:0000338)	4.05980896
11	interferon-gamma production (GO:0032609)	4.00114338
12	response to pheromone (GO:0019236)	3.96065794
13	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.79082646
14	termination of RNA polymerase III transcription (GO:0006386)	3.79082646
15	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.76988038
16	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.62846027
17	pseudouridine synthesis (GO:0001522)	3.52818415
18	peptidyl-histidine modification (GO:0018202)	3.51785371
19	L-fucose metabolic process (GO:0042354)	3.50588724
20	L-fucose catabolic process (GO:0042355)	3.50588724
21	fucose catabolic process (GO:0019317)	3.50588724
22	indolalkylamine metabolic process (GO:0006586)	3.48210003
23	regulation of cellular amino acid metabolic process (GO:0006521)	3.42972887
24	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.42420840
25	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.36836011
26	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.33084534
27	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.33084534
28	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.33084534
29	DNA catabolic process, exonucleolytic (GO:0000738)	3.32269588
30	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.27216836
31	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.26290939
32	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.26290939
33	postreplication repair (GO:0006301)	3.25959303
34	positive regulation of DNA recombination (GO:0045911)	3.25658039
35	regulation of chronic inflammatory response (GO:0002676)	3.24009419
36	termination of RNA polymerase I transcription (GO:0006363)	3.20986495
37	mannosylation (GO:0097502)	3.19295064
38	respiratory chain complex IV assembly (GO:0008535)	3.16904344
39	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.16382384
40	signal transduction involved in DNA damage checkpoint (GO:0072422)	3.15005098
41	signal transduction involved in DNA integrity checkpoint (GO:0072401)	3.15005098
42	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.13999628
43	negative regulation of ligase activity (GO:0051352)	3.12063495
44	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.12063495
45	signal transduction involved in cell cycle checkpoint (GO:0072395)	3.10131604
46	water-soluble vitamin biosynthetic process (GO:0042364)	3.05612695
47	nucleobase biosynthetic process (GO:0046112)	3.05256059
48	positive regulation of protein homooligomerization (GO:0032464)	3.02361566
49	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.01571057
50	protein-cofactor linkage (GO:0018065)	2.97510897
51	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.90725264
52	ribosome biogenesis (GO:0042254)	2.88993377
53	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.88924106
54	purine nucleobase biosynthetic process (GO:0009113)	2.88645244
55	branched-chain amino acid catabolic process (GO:0009083)	2.88271125
56	regulation of isotype switching to IgG isotypes (GO:0048302)	2.86641476
57	regulation of immunoglobulin secretion (GO:0051023)	2.84519489
58	positive regulation of defense response to virus by host (GO:0002230)	2.83220868
59	DNA damage response, detection of DNA damage (GO:0042769)	2.82760900
60	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.81433898
61	isotype switching (GO:0045190)	2.81433898
62	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.81433898
63	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.80548033
64	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.79926558
65	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.76833098
66	mitochondrial respiratory chain complex assembly (GO:0033108)	2.76295135
67	IMP biosynthetic process (GO:0006188)	2.75845961
68	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.75764897
69	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	2.73080826
70	mitochondrial RNA metabolic process (GO:0000959)	2.71931626
71	rRNA modification (GO:0000154)	2.71144354
72	replication fork processing (GO:0031297)	2.70281304
73	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.67434595
74	NADH dehydrogenase complex assembly (GO:0010257)	2.67434595
75	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.67434595
76	ribosome assembly (GO:0042255)	2.67142402
77	DNA damage response, signal transduction by p53 class mediator (GO:0030330)	2.65482753
78	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	2.65318446
79	protein complex biogenesis (GO:0070271)	2.64527071
80	cytochrome complex assembly (GO:0017004)	2.64166185
81	terpenoid biosynthetic process (GO:0016114)	2.63765914
82	ncRNA catabolic process (GO:0034661)	2.63018319
83	T-helper cell differentiation (GO:0042093)	2.60541739
84	CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)	2.60541739
85	cytidine deamination (GO:0009972)	2.60066869
86	cytidine metabolic process (GO:0046087)	2.60066869
87	cytidine catabolic process (GO:0006216)	2.60066869
88	alpha-beta T cell differentiation involved in immune response (GO:0002293)	2.58174267
89	alpha-beta T cell activation involved in immune response (GO:0002287)	2.58174267
90	T cell differentiation involved in immune response (GO:0002292)	2.58174267
91	chaperone-mediated protein transport (GO:0072321)	2.57365467
92	alpha-beta T cell differentiation (GO:0046632)	2.56516170
93	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.55258416
94	ATP synthesis coupled proton transport (GO:0015986)	2.55258416
95	transcription initiation from RNA polymerase I promoter (GO:0006361)	2.55123272
96	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.54054964
97	regulation of cellular amine metabolic process (GO:0033238)	2.52770057
98	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.52603524
99	negative regulation of meiosis (GO:0045835)	2.52126332
100	histone H2A ubiquitination (GO:0033522)	2.51530907

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	6.32223371
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.34614889
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.15210556
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.91840993
5	NOTCH1_21737748_ChIP-Seq_TLL_Human	3.61194806
6	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.18286147
7	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.09954282
8	ELK1_19687146_ChIP-ChIP_HELA_Human	3.05076040
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.93458841
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.82984504
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.78885476
12	VDR_23849224_ChIP-Seq_CD4+_Human	2.75208140
13	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.74066544
14	VDR_22108803_ChIP-Seq_LS180_Human	2.70981625
15	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.69034012
16	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.52459187
17	ZNF274_21170338_ChIP-Seq_K562_Hela	2.41950094
18	FOXP3_21729870_ChIP-Seq_TREG_Human	2.17604155
19	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.14630250
20	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.98358918
21	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.90510629
22	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.90417984
23	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.83058838
24	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.78072676
25	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.75691045
26	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.75084152
27	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.68749087
28	IGF1R_20145208_ChIP-Seq_DFB_Human	1.66095672
29	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.62335548
30	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.59048586
31	MYC_18940864_ChIP-ChIP_HL60_Human	1.54415455
32	DCP1A_22483619_ChIP-Seq_HELA_Human	1.54394343
33	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.54301311
34	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.54233407
35	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.51588425
36	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.46031042
37	FUS_26573619_Chip-Seq_HEK293_Human	1.44934005
38	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.41721672
39	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.41134769
40	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.39197931
41	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.37638276
42	GATA3_26560356_Chip-Seq_TH2_Human	1.36014403
43	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.34718040
44	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.32961826
45	GABP_19822575_ChIP-Seq_HepG2_Human	1.32382157
46	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.30949302
47	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.28026578
48	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.25690512
49	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.24650372
50	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.24468659
51	TTF2_22483619_ChIP-Seq_HELA_Human	1.23918517
52	EWS_26573619_Chip-Seq_HEK293_Human	1.22899695
53	ER_23166858_ChIP-Seq_MCF-7_Human	1.20566383
54	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.20379051
55	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.20291491
56	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.18911552
57	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.14745123
58	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.12656649
59	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.11123664
60	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.10658068
61	CBP_20019798_ChIP-Seq_JUKART_Human	1.10658068
62	TP53_22573176_ChIP-Seq_HFKS_Human	1.10247360
63	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.09347270
64	P300_19829295_ChIP-Seq_ESCs_Human	1.08166456
65	AR_20517297_ChIP-Seq_VCAP_Human	1.06939857
66	MYB_26560356_Chip-Seq_TH2_Human	1.06640052
67	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.05672527
68	NANOG_19829295_ChIP-Seq_ESCs_Human	1.05330295
69	SOX2_19829295_ChIP-Seq_ESCs_Human	1.05330295
70	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.98855816
71	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.98014492
72	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.98014492
73	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.94856723
74	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.94854317
75	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.94724078
76	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.93995578
77	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.93539626
78	BCAT_22108803_ChIP-Seq_LS180_Human	0.93176524
79	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.92102021
80	NCOR_22424771_ChIP-Seq_293T_Human	0.91567279
81	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.91346330
82	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.90006197
83	TAF15_26573619_Chip-Seq_HEK293_Human	0.89517299
84	RBPJ_21746931_ChIP-Seq_IB4_Human	0.89473389
85	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.88070245
86	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.87492001
87	GATA3_26560356_Chip-Seq_TH1_Human	0.87085421
88	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	0.86925295
89	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.86501880
90	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.86124694
91	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.85582442
92	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.85539351
93	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.85139975
94	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.84531370
95	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.83936081
96	HOXB7_26014856_ChIP-Seq_BT474_Human	0.83692155
97	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.83688529
98	TCF4_22108803_ChIP-Seq_LS180_Human	0.83449488
99	PHF8_20622853_ChIP-Seq_HELA_Human	0.82483850
100	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	0.82382579

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	4.59186422
2	MP0003195_calcinosis	4.15738680
3	MP0006082_CNS_inflammation	2.95737337
4	MP0002163_abnormal_gland_morphology	2.82530624
5	MP0001835_abnormal_antigen_presentation	2.82442663
6	MP0006054_spinal_hemorrhage	2.80720541
7	MP0009785_altered_susceptibility_to	2.66829505
8	MP0005671_abnormal_response_to	2.66296249
9	MP0003950_abnormal_plasma_membrane	2.62498333
10	MP0003646_muscle_fatigue	2.49878998
11	MP0008877_abnormal_DNA_methylation	2.38245832
12	MP0002148_abnormal_hypersensitivity_rea	2.35876512
13	MP0008058_abnormal_DNA_repair	2.34961087
14	MP0004147_increased_porphyrin_level	2.34295907
15	MP0000685_abnormal_immune_system	2.33567007
16	MP0008875_abnormal_xenobiotic_pharmacok	2.13427317
17	MP0008872_abnormal_physiological_respon	2.06620578
18	MP0002876_abnormal_thyroid_physiology	2.05986044
19	MP0001348_abnormal_lacrimal_gland	2.01876977
20	MP0004145_abnormal_muscle_electrophysio	1.94427570
21	MP0003718_maternal_effect	1.94205910
22	MP0001790_abnormal_immune_system	1.93535850
23	MP0005387_immune_system_phenotype	1.93535850
24	MP0001800_abnormal_humoral_immune	1.90524505
25	MP0005310_abnormal_salivary_gland	1.87549448
26	MP0009333_abnormal_splenocyte_physiolog	1.86206952
27	MP0004043_abnormal_pH_regulation	1.79345932
28	MP0005000_abnormal_immune_tolerance	1.78679765
29	MP0006072_abnormal_retinal_apoptosis	1.76894745
30	MP0002006_tumorigenesis	1.74278209
31	MP0001873_stomach_inflammation	1.74110262
32	MP0000372_irregular_coat_pigmentation	1.69369281
33	MP0009764_decreased_sensitivity_to	1.63534602
34	MP0002166_altered_tumor_susceptibility	1.63110905
35	MP0005379_endocrine/exocrine_gland_phen	1.57124631
36	MP0005253_abnormal_eye_physiology	1.53328024
37	MP0001984_abnormal_olfaction	1.46639972
38	MP0002723_abnormal_immune_serum	1.46014129
39	MP0005084_abnormal_gallbladder_morpholo	1.45076932
40	MP0003786_premature_aging	1.44069032
41	MP0002452_abnormal_antigen_presenting	1.37991982
42	MP0010094_abnormal_chromosome_stability	1.37360264
43	MP0005670_abnormal_white_adipose	1.34742252
44	MP0001986_abnormal_taste_sensitivity	1.30279994
45	MP0004142_abnormal_muscle_tone	1.27054458
46	MP0002693_abnormal_pancreas_physiology	1.26784875
47	MP0005075_abnormal_melanosome_morpholog	1.26529539
48	MP0006036_abnormal_mitochondrial_physio	1.25247671
49	MP0005167_abnormal_blood-brain_barrier	1.24816377
50	MP0001501_abnormal_sleep_pattern	1.23910761
51	MP0002420_abnormal_adaptive_immunity	1.21141343
52	MP0001819_abnormal_immune_cell	1.20765422
53	MP0005360_urolithiasis	1.17791922
54	MP0004215_abnormal_myocardial_fiber	1.15284500
55	MP0000569_abnormal_digit_pigmentation	1.15263847
56	MP0003763_abnormal_thymus_physiology	1.14663803
57	MP0005551_abnormal_eye_electrophysiolog	1.14441779
58	MP0005025_abnormal_response_to	1.11818760
59	MP0003221_abnormal_cardiomyocyte_apopto	1.09217179
60	MP0003045_fibrosis	1.08279510
61	MP0008007_abnormal_cellular_replicative	1.08259742
62	MP0002398_abnormal_bone_marrow	1.01814938
63	MP0002277_abnormal_respiratory_mucosa	1.01382976
64	MP0005395_other_phenotype	0.97715800
65	MP0001346_abnormal_lacrimal_gland	0.94951116
66	MP0001845_abnormal_inflammatory_respons	0.93500223
67	MP0000689_abnormal_spleen_morphology	0.92623497
68	MP0009840_abnormal_foam_cell	0.90596925
69	MP0001764_abnormal_homeostasis	0.90271345
70	MP0001502_abnormal_circadian_rhythm	0.89842512
71	MP0000716_abnormal_immune_system	0.87670790
72	MP0010155_abnormal_intestine_physiology	0.86703348
73	MP0005408_hypopigmentation	0.83489087
74	MP0003186_abnormal_redox_activity	0.78078623
75	MP0008469_abnormal_protein_level	0.78043831
76	MP0005083_abnormal_biliary_tract	0.77125848
77	MP0002722_abnormal_immune_system	0.74874979
78	MP0009697_abnormal_copulation	0.74791519
79	MP0000703_abnormal_thymus_morphology	0.74667028
80	MP0004957_abnormal_blastocyst_morpholog	0.74516676
81	MP0003567_abnormal_fetal_cardiomyocyte	0.73755504
82	MP0003693_abnormal_embryo_hatching	0.72636754
83	MP0002234_abnormal_pharynx_morphology	0.71605621
84	MP0002429_abnormal_blood_cell	0.68302304
85	MP0002419_abnormal_innate_immunity	0.68288859
86	MP0001905_abnormal_dopamine_level	0.68216858
87	MP0005636_abnormal_mineral_homeostasis	0.66069927
88	MP0005085_abnormal_gallbladder_physiolo	0.64125310
89	MP0006035_abnormal_mitochondrial_morpho	0.63572247
90	MP0001293_anophthalmia	0.63031206
91	MP0008873_increased_physiological_sensi	0.62866613
92	MP0001529_abnormal_vocalization	0.61513494
93	MP0003183_abnormal_peptide_metabolism	0.60890138
94	MP0001191_abnormal_skin_condition	0.60663950
95	MP0002019_abnormal_tumor_incidence	0.59726154
96	MP0002210_abnormal_sex_determination	0.59564365
97	MP0003448_altered_tumor_morphology	0.59527288
98	MP0003806_abnormal_nucleotide_metabolis	0.58760940
99	MP0003866_abnormal_defecation	0.58425750
100	MP0001486_abnormal_startle_reflex	0.58329103

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Optic neuritis (HP:0100653)	5.70212427
2	Retrobulbar optic neuritis (HP:0100654)	5.70212427
3	Orchitis (HP:0100796)	4.83499036
4	Myositis (HP:0100614)	4.20834459
5	Keratoconjunctivitis (HP:0001096)	3.68474995
6	Keratoconjunctivitis sicca (HP:0001097)	3.64916316
7	Increased serum lactate (HP:0002151)	3.40301511
8	Increased CSF lactate (HP:0002490)	3.32295549
9	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.28937583
10	Mitochondrial inheritance (HP:0001427)	3.25650989
11	Acute necrotizing encephalopathy (HP:0006965)	3.13369554
12	IgG deficiency (HP:0004315)	3.10039103
13	Increased hepatocellular lipid droplets (HP:0006565)	2.95050002
14	Pancreatic cysts (HP:0001737)	2.94488066
15	Hypoproteinemia (HP:0003075)	2.93117285
16	3-Methylglutaconic aciduria (HP:0003535)	2.88237852
17	Congenital stationary night blindness (HP:0007642)	2.87598149
18	Hepatocellular necrosis (HP:0001404)	2.85790658
19	Lipid accumulation in hepatocytes (HP:0006561)	2.81816413
20	Acute encephalopathy (HP:0006846)	2.74050451
21	Hypothermia (HP:0002045)	2.69143544
22	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.69060674
23	Abnormality of the pons (HP:0007361)	2.68835487
24	Elevated erythrocyte sedimentation rate (HP:0003565)	2.68363651
25	Stomatitis (HP:0010280)	2.66398407
26	Abnormal albumin level (HP:0012116)	2.66214278
27	Hypoalbuminemia (HP:0003073)	2.66214278
28	Abnormal mitochondria in muscle tissue (HP:0008316)	2.62535377
29	Encephalitis (HP:0002383)	2.61174238
30	Hepatic necrosis (HP:0002605)	2.59806599
31	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.58440591
32	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.58440591
33	Progressive macrocephaly (HP:0004481)	2.56967100
34	Colon cancer (HP:0003003)	2.56515783
35	Type II lissencephaly (HP:0007260)	2.48238032
36	Chronic hepatic failure (HP:0100626)	2.43447127
37	Abnormality of the renal cortex (HP:0011035)	2.41270382
38	Hypoplasia of the pons (HP:0012110)	2.40191379
39	Lactic acidosis (HP:0003128)	2.38724841
40	Pulmonary infiltrates (HP:0002113)	2.37105460
41	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.32868423
42	Abnormality of T cell physiology (HP:0011840)	2.22067952
43	Hemoptysis (HP:0002105)	2.21619628
44	Abnormality of macular pigmentation (HP:0008002)	2.20597447
45	Keratitis (HP:0000491)	2.20493186
46	Large for gestational age (HP:0001520)	2.19859229
47	Optic disc pallor (HP:0000543)	2.17309241
48	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.16286412
49	Abnormality of midbrain morphology (HP:0002418)	2.15609170
50	Molar tooth sign on MRI (HP:0002419)	2.15609170
51	Constricted visual fields (HP:0001133)	2.15071909
52	Progressive microcephaly (HP:0000253)	2.13758872
53	Arterial thrombosis (HP:0004420)	2.13582321
54	Congenital, generalized hypertrichosis (HP:0004540)	2.12315393
55	Optic nerve coloboma (HP:0000588)	2.10205425
56	Exertional dyspnea (HP:0002875)	2.10162127
57	Type I transferrin isoform profile (HP:0003642)	2.09226049
58	Anorexia (HP:0002039)	2.04072763
59	Cerebral edema (HP:0002181)	2.03390601
60	Joint swelling (HP:0001386)	2.02220527
61	Eosinophilia (HP:0001880)	2.00183666
62	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.99525868
63	Gangrene (HP:0100758)	1.99337348
64	Febrile seizures (HP:0002373)	1.97778884
65	Abnormality of eosinophils (HP:0001879)	1.97708942
66	Stomach cancer (HP:0012126)	1.97431802
67	Portal hypertension (HP:0001409)	1.92847947
68	Generalized aminoaciduria (HP:0002909)	1.92070093
69	Poor head control (HP:0002421)	1.91592066
70	Abnormal rod and cone electroretinograms (HP:0008323)	1.89849111
71	Parakeratosis (HP:0001036)	1.85608321
72	Renal cortical cysts (HP:0000803)	1.85277105
73	Volvulus (HP:0002580)	1.83950434
74	Exercise intolerance (HP:0003546)	1.83749732
75	Respiratory failure (HP:0002878)	1.83732986
76	Abnormal glycosylation (HP:0012345)	1.81902118
77	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.81902118
78	Abnormal protein N-linked glycosylation (HP:0012347)	1.81902118
79	Abnormal protein glycosylation (HP:0012346)	1.81902118
80	Cerebellar dysplasia (HP:0007033)	1.81675981
81	Carpal bone hypoplasia (HP:0001498)	1.81487388
82	Fibular aplasia (HP:0002990)	1.80543923
83	Abnormality of T cells (HP:0002843)	1.80262851
84	Tetraparesis (HP:0002273)	1.79247924
85	Stenosis of the external auditory canal (HP:0000402)	1.78904669
86	Abnormality of proline metabolism (HP:0010907)	1.77692058
87	Hydroxyprolinuria (HP:0003080)	1.77692058
88	Cortical visual impairment (HP:0100704)	1.76123522
89	Abnormal biliary tract physiology (HP:0012439)	1.75919080
90	Bile duct proliferation (HP:0001408)	1.75919080
91	Asplenia (HP:0001746)	1.75476585
92	Attenuation of retinal blood vessels (HP:0007843)	1.75286687
93	Autoimmune thrombocytopenia (HP:0001973)	1.75265011
94	True hermaphroditism (HP:0010459)	1.74042774
95	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.73877940
96	Abnormality of the hepatic vasculature (HP:0006707)	1.73781951
97	Chronic mucocutaneous candidiasis (HP:0002728)	1.72140381
98	Recurrent cutaneous fungal infections (HP:0011370)	1.72140381
99	Abolished electroretinogram (ERG) (HP:0000550)	1.71981436
100	Renal Fanconi syndrome (HP:0001994)	1.71871877

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP2K6	4.28968428
2	TXK	3.60449988
3	EIF2AK3	3.48314852
4	TSSK6	3.48173872
5	PBK	2.80536482
6	VRK2	2.70023522
7	STK16	2.62189185
8	MST4	2.59563832
9	EIF2AK1	2.51499669
10	NUAK1	2.46235321
11	ZAK	2.28873921
12	TAOK3	2.24941383
13	EPHA3	2.21593778
14	MKNK2	2.13653618
15	ADRBK2	1.98584511
16	TAF1	1.93751345
17	BUB1	1.91381464
18	BCKDK	1.68781642
19	SRPK1	1.66176083
20	BCR	1.65255605
21	INSRR	1.64833437
22	BMPR2	1.49698387
23	WNK4	1.38394990
24	TEC	1.34952354
25	PLK2	1.34665848
26	MKNK1	1.33465182
27	TRIM28	1.33218298
28	TGFBR2	1.30917819
29	IKBKB	1.26614126
30	MUSK	1.24586164
31	PIK3CG	1.22801518
32	NEK1	1.20969709
33	PNCK	1.20455935
34	GRK1	1.20369635
35	FRK	1.18388694
36	PLK3	1.17174451
37	ITK	1.15107844
38	BRD4	1.13479467
39	TLK1	1.07952248
40	NME2	1.06454274
41	WEE1	1.04934251
42	TIE1	1.02709635
43	GRK7	1.01566617
44	CASK	1.01525275
45	STK38L	1.01371846
46	NLK	1.00615693
47	MST1R	0.98492510
48	VRK1	0.96536466
49	GRK5	0.95590132
50	EIF2AK2	0.95333224
51	STK39	0.94218462
52	OXSR1	0.85562369
53	MAP3K14	0.85434438
54	PASK	0.84629986
55	WNK3	0.80334644
56	JAK3	0.80036273
57	MAPKAPK5	0.77908069
58	GRK6	0.74566581
59	CSNK1A1L	0.69791676
60	IKBKE	0.66784122
61	PLK4	0.66782030
62	KIT	0.65133549
63	MAP4K2	0.64134511
64	ADRBK1	0.62929667
65	TGFBR1	0.55815864
66	IRAK1	0.49872244
67	IGF1R	0.49436108
68	BMPR1B	0.48634977
69	DAPK1	0.48598001
70	CDK3	0.48048319
71	NME1	0.47573646
72	TNIK	0.46834806
73	RPS6KA5	0.46446123
74	MAP3K2	0.45654000
75	MAPKAPK3	0.45395383
76	CSNK1G3	0.43800152
77	STK10	0.43641075
78	CSNK1G2	0.42516976
79	PRKCE	0.42476305
80	ERBB3	0.40741789
81	MAP4K1	0.40511831
82	CSNK1G1	0.39668462
83	ACVR1B	0.36838034
84	CDK9	0.36421126
85	MAPKAPK2	0.35234705
86	TYK2	0.32544590
87	CAMK2A	0.32225780
88	TBK1	0.31543236
89	EPHA2	0.30958911
90	CAMKK2	0.30633287
91	ALK	0.29652501
92	DYRK2	0.29386993
93	ATR	0.28944828
94	LCK	0.28801529
95	CSNK2A1	0.26532534
96	CCNB1	0.25893568
97	CSNK2A2	0.25108516
98	ATM	0.24904889
99	LYN	0.24293643
100	CDK7	0.23766536

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.80539998
2	RNA polymerase_Homo sapiens_hsa03020	3.80904251
3	Protein export_Homo sapiens_hsa03060	3.69430979
4	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.90041068
5	Graft-versus-host disease_Homo sapiens_hsa05332	2.42374567
6	Allograft rejection_Homo sapiens_hsa05330	2.38860020
7	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.38304274
8	Oxidative phosphorylation_Homo sapiens_hsa00190	2.26045643
9	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.17212869
10	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.12966050
11	Basal transcription factors_Homo sapiens_hsa03022	2.08987214
12	Asthma_Homo sapiens_hsa05310	2.05441263
13	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.98934192
14	RNA degradation_Homo sapiens_hsa03018	1.98593270
15	Homologous recombination_Homo sapiens_hsa03440	1.94338817
16	Non-homologous end-joining_Homo sapiens_hsa03450	1.92476592
17	Parkinsons disease_Homo sapiens_hsa05012	1.90772388
18	Nitrogen metabolism_Homo sapiens_hsa00910	1.80461618
19	One carbon pool by folate_Homo sapiens_hsa00670	1.74729743
20	Type I diabetes mellitus_Homo sapiens_hsa04940	1.70082436
21	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.66858027
22	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.65428815
23	Propanoate metabolism_Homo sapiens_hsa00640	1.58780410
24	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.54042909
25	Antigen processing and presentation_Homo sapiens_hsa04612	1.45083509
26	Huntingtons disease_Homo sapiens_hsa05016	1.44807406
27	Alzheimers disease_Homo sapiens_hsa05010	1.40580394
28	Spliceosome_Homo sapiens_hsa03040	1.35675275
29	RNA transport_Homo sapiens_hsa03013	1.32000804
30	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.30747384
31	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.28826221
32	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.28732839
33	Ribosome_Homo sapiens_hsa03010	1.28686134
34	Pyrimidine metabolism_Homo sapiens_hsa00240	1.28623469
35	Primary immunodeficiency_Homo sapiens_hsa05340	1.22502408
36	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.19747368
37	Selenocompound metabolism_Homo sapiens_hsa00450	1.19442768
38	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.17869243
39	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.15615095
40	Sulfur metabolism_Homo sapiens_hsa00920	1.08722604
41	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.05129580
42	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.03526723
43	Tryptophan metabolism_Homo sapiens_hsa00380	0.99832510
44	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.99614938
45	Base excision repair_Homo sapiens_hsa03410	0.97475024
46	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.90501259
47	Purine metabolism_Homo sapiens_hsa00230	0.90261815
48	Fanconi anemia pathway_Homo sapiens_hsa03460	0.86592550
49	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.86058841
50	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.84297261
51	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.83013996
52	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.82927669
53	Mismatch repair_Homo sapiens_hsa03430	0.81992639
54	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.80318162
55	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.78962193
56	Steroid biosynthesis_Homo sapiens_hsa00100	0.78423794
57	Linoleic acid metabolism_Homo sapiens_hsa00591	0.76679079
58	Legionellosis_Homo sapiens_hsa05134	0.76356382
59	Rheumatoid arthritis_Homo sapiens_hsa05323	0.76018114
60	Nucleotide excision repair_Homo sapiens_hsa03420	0.75993545
61	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.73811610
62	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.72176492
63	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.70924596
64	Cardiac muscle contraction_Homo sapiens_hsa04260	0.69109343
65	Butanoate metabolism_Homo sapiens_hsa00650	0.69028389
66	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.67568351
67	Caffeine metabolism_Homo sapiens_hsa00232	0.62063441
68	Ether lipid metabolism_Homo sapiens_hsa00565	0.61263853
69	Measles_Homo sapiens_hsa05162	0.61059093
70	Phototransduction_Homo sapiens_hsa04744	0.61014307
71	Viral myocarditis_Homo sapiens_hsa05416	0.59123360
72	Herpes simplex infection_Homo sapiens_hsa05168	0.55472610
73	Metabolic pathways_Homo sapiens_hsa01100	0.54501523
74	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.53269316
75	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.51180498
76	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.49354422
77	Circadian rhythm_Homo sapiens_hsa04710	0.45566932
78	Pyruvate metabolism_Homo sapiens_hsa00620	0.45363736
79	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.45014426
80	Mineral absorption_Homo sapiens_hsa04978	0.43100039
81	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.42970577
82	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.42121079
83	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.41746509
84	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.40258594
85	DNA replication_Homo sapiens_hsa03030	0.37110296
86	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.33656014
87	p53 signaling pathway_Homo sapiens_hsa04115	0.32737744
88	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.32012735
89	Peroxisome_Homo sapiens_hsa04146	0.31249173
90	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.30801280
91	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.30527041
92	African trypanosomiasis_Homo sapiens_hsa05143	0.28522124
93	Taste transduction_Homo sapiens_hsa04742	0.28057134
94	Chemical carcinogenesis_Homo sapiens_hsa05204	0.25484664
95	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.24880688
96	Retinol metabolism_Homo sapiens_hsa00830	0.20905597
97	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.20626677
98	Regulation of autophagy_Homo sapiens_hsa04140	0.19543398
99	Nicotine addiction_Homo sapiens_hsa05033	0.18840373
100	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.18290261

BZW1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »