BZW1P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosome assembly (GO:0042255)6.06876020
2negative regulation of retinoic acid receptor signaling pathway (GO:0048387)5.39276590
3regulation of retinoic acid receptor signaling pathway (GO:0048385)5.06246260
4nuclear pore complex assembly (GO:0051292)4.80745624
5pore complex assembly (GO:0046931)4.12238988
6nuclear pore organization (GO:0006999)4.06459595
7establishment of integrated proviral latency (GO:0075713)3.98305251
8folic acid-containing compound biosynthetic process (GO:0009396)3.56614472
9mitotic metaphase plate congression (GO:0007080)3.55617655
10negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.54852397
11positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.54465335
12regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.46822782
13positive regulation of immune response to tumor cell (GO:0002839)3.44972526
14regulation of immune response to tumor cell (GO:0002837)3.44972526
15regulation of response to tumor cell (GO:0002834)3.44972526
16positive regulation of response to tumor cell (GO:0002836)3.44972526
17proteasome assembly (GO:0043248)3.42912121
18rRNA modification (GO:0000154)3.42685814
19negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.38460566
20negative regulation of ligase activity (GO:0051352)3.38460566
21regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.37562012
22ribosome biogenesis (GO:0042254)3.36860532
23anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.35618425
24cell adhesion mediated by integrin (GO:0033627)3.35524688
25regulation of vitamin D biosynthetic process (GO:0060556)3.30395300
26regulation of cellular amino acid metabolic process (GO:0006521)3.29267227
27establishment of viral latency (GO:0019043)3.26744698
28nucleobase-containing small molecule interconversion (GO:0015949)3.24128411
29metaphase plate congression (GO:0051310)3.22263024
30regulation of translational termination (GO:0006449)3.20388987
31non-recombinational repair (GO:0000726)3.12573120
32double-strand break repair via nonhomologous end joining (GO:0006303)3.12573120
33ER overload response (GO:0006983)3.11780754
34signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.08074316
35signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.08074316
36signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.08074316
37protein localization to microtubule (GO:0035372)3.07924737
38intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.07025146
39signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.07025146
40rRNA methylation (GO:0031167)3.04885732
41DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.04684270
42maturation of 5.8S rRNA (GO:0000460)3.04649991
43mitotic sister chromatid cohesion (GO:0007064)3.04160239
44positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.03255915
45regulation of chronic inflammatory response (GO:0002676)3.02531278
46signal transduction involved in DNA integrity checkpoint (GO:0072401)3.01629964
47signal transduction involved in DNA damage checkpoint (GO:0072422)3.01629964
48COPI coating of Golgi vesicle (GO:0048205)3.01467162
49Golgi transport vesicle coating (GO:0048200)3.01467162
50antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.97618408
51establishment of chromosome localization (GO:0051303)2.96956928
52positive regulation of ligase activity (GO:0051351)2.96820771
53signal transduction involved in cell cycle checkpoint (GO:0072395)2.95948774
54tRNA aminoacylation for protein translation (GO:0006418)2.94643174
55amino acid activation (GO:0043038)2.93283399
56tRNA aminoacylation (GO:0043039)2.93283399
57COPII vesicle coating (GO:0048208)2.85085594
58regulation of centriole replication (GO:0046599)2.84358531
59antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.84017625
60formation of translation preinitiation complex (GO:0001731)2.83597984
61protein localization to chromosome, centromeric region (GO:0071459)2.77826118
62membrane raft organization (GO:0031579)2.75894781
63mitotic nuclear envelope disassembly (GO:0007077)2.75824222
64regulation of ubiquitin-protein transferase activity (GO:0051438)2.73324440
65pteridine-containing compound biosynthetic process (GO:0042559)2.72399616
66regulation of vitamin metabolic process (GO:0030656)2.70938268
67positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.69482402
68regulation of ligase activity (GO:0051340)2.69250228
69regulation of metalloenzyme activity (GO:0048552)2.67562583
70natural killer cell mediated cytotoxicity (GO:0042267)2.66401123
71natural killer cell mediated immunity (GO:0002228)2.66401123
72chaperone mediated protein folding requiring cofactor (GO:0051085)2.65908943
73antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.63209603
74response to X-ray (GO:0010165)2.61649988
75rRNA processing (GO:0006364)2.61506726
76regulation of translation in response to stress (GO:0043555)2.61383457
77membrane disassembly (GO:0030397)2.60544184
78nuclear envelope disassembly (GO:0051081)2.60544184
79cell cycle G1/S phase transition (GO:0044843)2.60337908
80G1/S transition of mitotic cell cycle (GO:0000082)2.60337908
81protein localization to kinetochore (GO:0034501)2.58973068
82negative regulation of protein ubiquitination (GO:0031397)2.58592164
83purine nucleobase biosynthetic process (GO:0009113)2.57380089
84tRNA methylation (GO:0030488)2.51268787
85DNA strand elongation involved in DNA replication (GO:0006271)2.51266802
86rRNA metabolic process (GO:0016072)2.50368707
87somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.50322018
88isotype switching (GO:0045190)2.50322018
89somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.50322018
90DNA strand elongation (GO:0022616)2.49800656
91nucleobase biosynthetic process (GO:0046112)2.47518072
92ribonucleoprotein complex biogenesis (GO:0022613)2.46205038
93mitochondrial RNA metabolic process (GO:0000959)2.45661234
94negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.45267075
95transcription elongation from RNA polymerase I promoter (GO:0006362)2.42255399
96nucleotide-sugar biosynthetic process (GO:0009226)2.42244716
97termination of RNA polymerase I transcription (GO:0006363)2.39483151
98mitochondrial DNA replication (GO:0006264)2.36833726
99intestinal epithelial cell development (GO:0060576)2.36722571
100de novo protein folding (GO:0006458)2.36172345

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.80920712
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.98995582
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.47269432
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.38995802
5ELK1_19687146_ChIP-ChIP_HELA_Human2.98079053
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.95620295
7SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.93784654
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.85385217
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.84132146
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.58481289
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.56852249
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.52607055
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.43836459
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.35619682
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.21815778
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.16714560
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.14944566
18VDR_23849224_ChIP-Seq_CD4+_Human2.14398960
19PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.12686426
20PADI4_21655091_ChIP-ChIP_MCF-7_Human2.10929416
21TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.10040753
22AR_21909140_ChIP-Seq_LNCAP_Human2.07402514
23FOXM1_23109430_ChIP-Seq_U2OS_Human2.01208406
24HOXB4_20404135_ChIP-ChIP_EML_Mouse1.98667731
25NOTCH1_21737748_ChIP-Seq_TLL_Human1.98179992
26KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.92322270
27EGR1_19374776_ChIP-ChIP_THP-1_Human1.91076255
28MYC_19030024_ChIP-ChIP_MESCs_Mouse1.89211286
29EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.88815118
30NELFA_20434984_ChIP-Seq_ESCs_Mouse1.85734137
31DCP1A_22483619_ChIP-Seq_HELA_Human1.81139611
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.76369971
33FOXP3_21729870_ChIP-Seq_TREG_Human1.72117109
34TP63_17297297_ChIP-ChIP_HaCaT_Human1.67248521
35MYC_18358816_ChIP-ChIP_MESCs_Mouse1.61533863
36HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.59349493
37IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.56764056
38ELK1_22589737_ChIP-Seq_MCF10A_Human1.54832413
39SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.53785958
40SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.53785958
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.53706310
42TFEB_21752829_ChIP-Seq_HELA_Human1.53180386
43CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.51743416
44MYCN_18555785_ChIP-Seq_MESCs_Mouse1.49629891
45MYC_19079543_ChIP-ChIP_MESCs_Mouse1.46817650
46HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.43843316
47E2F1_18555785_ChIP-Seq_MESCs_Mouse1.38951297
48SALL1_21062744_ChIP-ChIP_HESCs_Human1.38734020
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37427421
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.35757301
51STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.34052423
52IRF8_21731497_ChIP-ChIP_J774_Mouse1.31881753
53SRF_21415370_ChIP-Seq_HL-1_Mouse1.31851075
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.31545597
55BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.30384825
56BRD4_25478319_ChIP-Seq_HGPS_Human1.27671159
57PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.27196135
58GABP_19822575_ChIP-Seq_HepG2_Human1.25777526
59ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.25745818
60Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.25672314
61MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.23800587
62MYB_21317192_ChIP-Seq_ERMYB_Mouse1.23674148
63E2F1_21310950_ChIP-Seq_MCF-7_Human1.22789360
64FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.22505990
65ERG_20887958_ChIP-Seq_HPC-7_Mouse1.19328419
66STAT4_19710469_ChIP-ChIP_TH1__Mouse1.17907769
67POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.14929955
68SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.13662225
69TTF2_22483619_ChIP-Seq_HELA_Human1.12759500
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10726772
71MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.10372680
72MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09578902
73CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.09154230
74SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.08619827
75ELF5_23300383_ChIP-Seq_T47D_Human1.08187722
76ZNF263_19887448_ChIP-Seq_K562_Human1.04730756
77HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02777090
78HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.00750218
79ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00616088
80SOX17_20123909_ChIP-Seq_XEN_Mouse1.00562605
81SPI1_23547873_ChIP-Seq_NB4_Human1.00445581
82PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99853295
83ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99795273
84ZFX_18555785_ChIP-Seq_MESCs_Mouse0.99304514
85PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.96532037
86NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.94987235
87SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92547898
88MYB_26560356_Chip-Seq_TH2_Human0.92447117
89CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.92180429
90PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.91708818
91BP1_19119308_ChIP-ChIP_Hs578T_Human0.90930240
92CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.90292323
93ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.90137229
94FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.88972299
95EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.87867582
96NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.86892955
97GATA3_26560356_Chip-Seq_TH2_Human0.85844680
98SALL4_22934838_ChIP-ChIP_CD34+_Human0.84855189
99EGR1_23403033_ChIP-Seq_LIVER_Mouse0.84581197
100E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.83776315

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003950_abnormal_plasma_membrane3.58449944
2MP0003806_abnormal_nucleotide_metabolis3.52730903
3MP0010352_gastrointestinal_tract_polyps3.29081658
4MP0004957_abnormal_blastocyst_morpholog2.88805473
5MP0008057_abnormal_DNA_replication2.62947770
6MP0008058_abnormal_DNA_repair2.61087424
7MP0010094_abnormal_chromosome_stability2.52672339
8MP0003693_abnormal_embryo_hatching2.32449427
9MP0003111_abnormal_nucleus_morphology2.17262426
10MP0002877_abnormal_melanocyte_morpholog2.12240186
11MP0003077_abnormal_cell_cycle2.08002352
12MP0008007_abnormal_cellular_replicative2.07315151
13MP0006054_spinal_hemorrhage2.00631376
14MP0003941_abnormal_skin_development2.00113233
15MP0001853_heart_inflammation1.94431888
16MP0009697_abnormal_copulation1.93232717
17MP0000569_abnormal_digit_pigmentation1.92274873
18MP0002006_tumorigenesis1.75407405
19MP0010234_abnormal_vibrissa_follicle1.74964149
20MP0003718_maternal_effect1.69501096
21MP0002148_abnormal_hypersensitivity_rea1.65140587
22MP0009785_altered_susceptibility_to1.60370564
23MP0001835_abnormal_antigen_presentation1.54895994
24MP0003566_abnormal_cell_adhesion1.52832466
25MP0002060_abnormal_skin_morphology1.52675363
26MP0005451_abnormal_body_composition1.51814256
27MP0001216_abnormal_epidermal_layer1.46400499
28MP0009333_abnormal_splenocyte_physiolog1.40750161
29MP0000358_abnormal_cell_content/1.40219104
30MP0004233_abnormal_muscle_weight1.39522986
31MP0003191_abnormal_cellular_cholesterol1.38181137
32MP0003786_premature_aging1.37632717
33MP0003868_abnormal_feces_composition1.36107053
34MP0003448_altered_tumor_morphology1.31855791
35MP0008438_abnormal_cutaneous_collagen1.30638750
36MP0002396_abnormal_hematopoietic_system1.30220374
37MP0003656_abnormal_erythrocyte_physiolo1.28415601
38MP0008932_abnormal_embryonic_tissue1.27337639
39MP0003300_gastrointestinal_ulcer1.26273214
40MP0002166_altered_tumor_susceptibility1.25179762
41MP0003186_abnormal_redox_activity1.22269227
42MP0003221_abnormal_cardiomyocyte_apopto1.21447567
43MP0010307_abnormal_tumor_latency1.20411797
44MP0005000_abnormal_immune_tolerance1.17992144
45MP0003763_abnormal_thymus_physiology1.17296857
46MP0010678_abnormal_skin_adnexa1.16956047
47MP0000627_abnormal_mammary_gland1.15842242
48MP0008260_abnormal_autophagy1.15650279
49MP0009764_decreased_sensitivity_to1.15222581
50MP0004947_skin_inflammation1.14787116
51MP0001730_embryonic_growth_arrest1.12182071
52MP0001881_abnormal_mammary_gland1.11554163
53MP0002796_impaired_skin_barrier1.10156531
54MP0005165_increased_susceptibility_to1.09644854
55MP0006035_abnormal_mitochondrial_morpho1.08773744
56MP0001243_abnormal_dermal_layer1.05099983
57MP0005501_abnormal_skin_physiology1.04514984
58MP0004808_abnormal_hematopoietic_stem1.03948624
59MP0000685_abnormal_immune_system1.03432772
60MP0005395_other_phenotype1.03257490
61MP0006082_CNS_inflammation1.02116433
62MP0005023_abnormal_wound_healing1.01037176
63MP0000350_abnormal_cell_proliferation1.00924342
64MP0003436_decreased_susceptibility_to1.00124630
65MP0002019_abnormal_tumor_incidence0.96970838
66MP0008875_abnormal_xenobiotic_pharmacok0.95553585
67MP0002452_abnormal_antigen_presenting0.95235112
68MP0001727_abnormal_embryo_implantation0.95035283
69MP0005164_abnormal_response_to0.94361759
70MP0003453_abnormal_keratinocyte_physiol0.93722982
71MP0003303_peritoneal_inflammation0.93566736
72MP0000465_gastrointestinal_hemorrhage0.93127431
73MP0002163_abnormal_gland_morphology0.92132930
74MP0004272_abnormal_basement_membrane0.91747952
75MP0002086_abnormal_extraembryonic_tissu0.90793651
76MP0001191_abnormal_skin_condition0.90669300
77MP0002332_abnormal_exercise_endurance0.89288386
78MP0001661_extended_life_span0.86353517
79MP0002080_prenatal_lethality0.85746000
80MP0001845_abnormal_inflammatory_respons0.84800238
81MP0005275_abnormal_skin_tensile0.83355524
82MP0005671_abnormal_response_to0.82881934
83MP0002398_abnormal_bone_marrow0.82848278
84MP0001697_abnormal_embryo_size0.82722491
85MP0000313_abnormal_cell_death0.82627560
86MP0009840_abnormal_foam_cell0.80766749
87MP0002723_abnormal_immune_serum0.80574293
88MP0000383_abnormal_hair_follicle0.79320358
89MP0010771_integument_phenotype0.79318562
90MP0001800_abnormal_humoral_immune0.79266868
91MP0003252_abnormal_bile_duct0.78685170
92MP0005384_cellular_phenotype0.76836082
93MP0001873_stomach_inflammation0.75577304
94MP0002722_abnormal_immune_system0.74148095
95MP0000858_altered_metastatic_potential0.73941732
96MP0009763_increased_sensitivity_to0.73809325
97MP0008469_abnormal_protein_level0.73575362
98MP0001819_abnormal_immune_cell0.73473187
99MP0002420_abnormal_adaptive_immunity0.73412223
100MP0001790_abnormal_immune_system0.73325777

Predicted human phenotypes

RankGene SetZ-score
1Oral leukoplakia (HP:0002745)3.88386021
2Onycholysis (HP:0001806)2.99096259
3Abnormality of methionine metabolism (HP:0010901)2.93606969
4Thick nail (HP:0001805)2.84473398
5Rough bone trabeculation (HP:0100670)2.84110078
6Aplastic anemia (HP:0001915)2.83244451
7Reduced antithrombin III activity (HP:0001976)2.74064404
8Amniotic constriction ring (HP:0009775)2.72870517
9Abnormality of placental membranes (HP:0011409)2.72870517
10Reduced subcutaneous adipose tissue (HP:0003758)2.58919642
11Autoamputation (HP:0001218)2.51525013
12Autoimmune hemolytic anemia (HP:0001890)2.51470100
13Type I transferrin isoform profile (HP:0003642)2.51117475
14Multiple enchondromatosis (HP:0005701)2.44576480
15Decreased activity of mitochondrial respiratory chain (HP:0008972)2.40644396
16Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.40644396
17Chromosomal breakage induced by crosslinking agents (HP:0003221)2.40219489
18Orthostatic hypotension (HP:0001278)2.35930203
19Sparse eyelashes (HP:0000653)2.35230210
20Abnormality of oral frenula (HP:0000190)2.33512043
21Abnormality of the preputium (HP:0100587)2.32981221
22Tetraparesis (HP:0002273)2.32419119
23Abnormal protein glycosylation (HP:0012346)2.30900063
24Abnormal glycosylation (HP:0012345)2.30900063
25Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.30900063
26Abnormal protein N-linked glycosylation (HP:0012347)2.30900063
27Abnormality of aspartate family amino acid metabolism (HP:0010899)2.26997750
28T lymphocytopenia (HP:0005403)2.26915219
29Increased hepatocellular lipid droplets (HP:0006565)2.25802844
30Abnormal trabecular bone morphology (HP:0100671)2.25246713
31Entropion (HP:0000621)2.25111078
32Chromsome breakage (HP:0040012)2.24452127
33Conjugated hyperbilirubinemia (HP:0002908)2.23517510
34Micronodular cirrhosis (HP:0001413)2.23517499
35Abnormalities of placenta or umbilical cord (HP:0001194)2.23060566
36Blepharitis (HP:0000498)2.14601967
373-Methylglutaconic aciduria (HP:0003535)2.13511923
38IgA deficiency (HP:0002720)2.12511332
39Nail dystrophy (HP:0008404)2.12388744
40Secondary amenorrhea (HP:0000869)2.12174101
41Plantar hyperkeratosis (HP:0007556)2.11933054
42Cardiovascular calcification (HP:0011915)2.11458644
43Upper limb muscle weakness (HP:0003484)2.08920829
44Abnormality of T cell number (HP:0011839)2.08641010
45Osteolytic defects of the hand bones (HP:0009699)2.08244242
46Osteolytic defects of the phalanges of the hand (HP:0009771)2.08244242
47Myocardial infarction (HP:0001658)2.06005831
48Vascular calcification (HP:0004934)2.01190347
49Increased serum pyruvate (HP:0003542)2.00395341
50Insidious onset (HP:0003587)1.97846130
51Termporal pattern (HP:0011008)1.97846130
52Papillary thyroid carcinoma (HP:0002895)1.94917068
53Palpitations (HP:0001962)1.94321232
54Abnormality of glycolysis (HP:0004366)1.93607884
55Abnormality of the intrinsic pathway (HP:0010989)1.93191588
56Dyschromatopsia (HP:0007641)1.91483699
57Progressive hearing impairment (HP:0001730)1.90646939
58Periodontitis (HP:0000704)1.90605943
59Lipid accumulation in hepatocytes (HP:0006561)1.90417753
60Generalized aminoaciduria (HP:0002909)1.89894254
61Stomatitis (HP:0010280)1.89583451
62IgG deficiency (HP:0004315)1.88944139
63Subacute progressive viral hepatitis (HP:0006572)1.88256808
64Milia (HP:0001056)1.87401960
65Aplasia cutis congenita (HP:0001057)1.86790875
66Volvulus (HP:0002580)1.86491771
67Congenital ichthyosiform erythroderma (HP:0007431)1.85001742
68Abnormality of the common coagulation pathway (HP:0010990)1.84702109
69Abnormality of chromosome stability (HP:0003220)1.83814709
70Microvesicular hepatic steatosis (HP:0001414)1.83657862
71Short tibia (HP:0005736)1.83623546
72Cellular immunodeficiency (HP:0005374)1.82826609
73Premature ovarian failure (HP:0008209)1.82511884
74Anhidrosis (HP:0000970)1.82488334
75Pancytopenia (HP:0001876)1.82330725
76Trismus (HP:0000211)1.81927855
77Ectropion (HP:0000656)1.80838450
78Neoplasm of the peripheral nervous system (HP:0100007)1.78379679
79Hypobetalipoproteinemia (HP:0003563)1.76516775
80Increased serum lactate (HP:0002151)1.76485018
81Hypoglycemic coma (HP:0001325)1.75885728
82Palmar hyperkeratosis (HP:0010765)1.75430984
83Palmoplantar hyperkeratosis (HP:0000972)1.73583218
84Progressive external ophthalmoplegia (HP:0000590)1.73339904
85Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.72016016
86Thyroid carcinoma (HP:0002890)1.71179742
87Prolonged partial thromboplastin time (HP:0003645)1.71149785
88Symptomatic seizures (HP:0011145)1.71070480
89Acute hepatic failure (HP:0006554)1.70797830
90Sparse lateral eyebrow (HP:0005338)1.70074985
91Retrobulbar optic neuritis (HP:0100654)1.66775803
92Optic neuritis (HP:0100653)1.66775803
93Follicular hyperkeratosis (HP:0007502)1.64422144
94Myelodysplasia (HP:0002863)1.64390150
95Deep philtrum (HP:0002002)1.64034630
96Abnormality of T cells (HP:0002843)1.63964574
97Progressive sensorineural hearing impairment (HP:0000408)1.63703533
98Pelvic girdle muscle weakness (HP:0003749)1.63344493
99Ankyloglossia (HP:0010296)1.63203891
100Abnormality of the umbilical cord (HP:0010881)1.63202322

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK34.07103998
2TSSK63.92734815
3EIF2AK13.77446310
4MST43.75446898
5MAP3K123.57670122
6PBK3.31203625
7SCYL22.99614632
8BUB12.78442377
9SRPK12.75761831
10NEK12.57636742
11IRAK32.44324115
12ZAK2.28170159
13MST1R2.02890833
14BRSK21.76510991
15PLK31.69313808
16PAK41.59407388
17BMPR21.59172933
18PDK21.57558925
19ERBB41.45195528
20STK101.40903622
21TTK1.38105422
22STK161.35965377
23STK38L1.30970471
24MAP3K141.28311770
25EIF2AK21.28078931
26ERBB31.24541724
27CDC71.22057264
28STK241.15223669
29CLK11.10405446
30TESK21.08820401
31PNCK1.05673316
32LATS21.01470324
33NME21.00458455
34STK30.99742220
35TRIM280.98061731
36MYLK0.97471892
37VRK10.95966129
38MAP4K20.89317576
39TGFBR20.87814270
40PLK40.85915265
41TXK0.85768509
42TAF10.85289782
43PLK10.83609004
44MET0.83158375
45AURKB0.82112666
46NUAK10.81812224
47NEK90.81426438
48PIM20.80850614
49MKNK10.77221997
50PLK20.75427735
51CDK80.72417041
52PIK3CG0.70567055
53VRK20.68193824
54BRD40.68128189
55NEK60.68010548
56TAOK30.67378984
57LATS10.66648605
58DAPK10.62506336
59RPS6KB20.60354346
60ARAF0.59026533
61CHEK10.56726725
62MAP2K60.56527330
63BCR0.56403621
64MKNK20.56351027
65RPS6KA40.56114187
66IKBKB0.55623086
67CHEK20.54173857
68TLK10.54012894
69ALK0.53198609
70STK40.52711059
71AURKA0.52633818
72ATM0.51916267
73CSNK1G10.51118325
74PAK20.50529130
75TESK10.50250246
76CDK90.48598467
77INSRR0.47521316
78EPHA20.47070153
79ATR0.46736516
80TEC0.45316153
81MAP3K50.45005766
82LIMK10.44912407
83MAP3K80.44118322
84CSNK1A1L0.43948515
85PRKCI0.43259117
86TRPM70.43153024
87MOS0.42476922
88CCNB10.41487894
89STK390.41370307
90JAK30.41242760
91GRK70.41198386
92CSNK1G30.37294803
93WEE10.35949269
94FLT30.35861634
95TBK10.33999297
96CDK60.33598011
97CSNK2A20.33297659
98CDK70.32812666
99IGF1R0.32678615
100CHUK0.29809788

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.87838894
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.12528456
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.09381166
4Protein export_Homo sapiens_hsa030603.06372813
5Non-homologous end-joining_Homo sapiens_hsa034502.58922341
6DNA replication_Homo sapiens_hsa030302.32592310
7RNA transport_Homo sapiens_hsa030132.20446916
8Mismatch repair_Homo sapiens_hsa034302.12327904
9Nucleotide excision repair_Homo sapiens_hsa034202.05277010
10Sulfur metabolism_Homo sapiens_hsa009202.03292590
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.85882025
12Spliceosome_Homo sapiens_hsa030401.85604217
13Basal transcription factors_Homo sapiens_hsa030221.83768253
14One carbon pool by folate_Homo sapiens_hsa006701.83483209
15RNA polymerase_Homo sapiens_hsa030201.81645254
16Pyrimidine metabolism_Homo sapiens_hsa002401.49465028
17Shigellosis_Homo sapiens_hsa051311.47993702
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.47762854
19RNA degradation_Homo sapiens_hsa030181.45270380
20Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.44530410
21Cell cycle_Homo sapiens_hsa041101.43522632
22Selenocompound metabolism_Homo sapiens_hsa004501.43344892
23Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.35994775
24Legionellosis_Homo sapiens_hsa051341.31372640
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.29647918
26Measles_Homo sapiens_hsa051621.16337093
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.14918589
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.14114623
29Steroid biosynthesis_Homo sapiens_hsa001001.12635635
30p53 signaling pathway_Homo sapiens_hsa041151.12082597
31Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.11158277
32Base excision repair_Homo sapiens_hsa034101.10242886
33Systemic lupus erythematosus_Homo sapiens_hsa053221.09735984
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.04459530
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.03664252
36Rheumatoid arthritis_Homo sapiens_hsa053230.96989544
37Epstein-Barr virus infection_Homo sapiens_hsa051690.94339260
38mRNA surveillance pathway_Homo sapiens_hsa030150.90347480
39Pentose and glucuronate interconversions_Homo sapiens_hsa000400.89685140
40Antigen processing and presentation_Homo sapiens_hsa046120.89179364
41Fatty acid elongation_Homo sapiens_hsa000620.89150301
42Homologous recombination_Homo sapiens_hsa034400.88025366
43Viral carcinogenesis_Homo sapiens_hsa052030.87731134
44Purine metabolism_Homo sapiens_hsa002300.85000591
45Herpes simplex infection_Homo sapiens_hsa051680.83983476
46Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.82575176
47Hematopoietic cell lineage_Homo sapiens_hsa046400.81260991
48NOD-like receptor signaling pathway_Homo sapiens_hsa046210.81044917
49Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.79831341
50Graft-versus-host disease_Homo sapiens_hsa053320.78723765
51Fanconi anemia pathway_Homo sapiens_hsa034600.78055697
52Carbon metabolism_Homo sapiens_hsa012000.75628891
53Type I diabetes mellitus_Homo sapiens_hsa049400.74727858
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71682845
55Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.71578535
56Regulation of autophagy_Homo sapiens_hsa041400.69945178
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69396063
58N-Glycan biosynthesis_Homo sapiens_hsa005100.68379243
59Salmonella infection_Homo sapiens_hsa051320.68294754
60Propanoate metabolism_Homo sapiens_hsa006400.67413911
61Vibrio cholerae infection_Homo sapiens_hsa051100.67343896
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66236532
63Apoptosis_Homo sapiens_hsa042100.66203082
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65881601
65Caffeine metabolism_Homo sapiens_hsa002320.65597096
66Allograft rejection_Homo sapiens_hsa053300.63598855
67Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.62960005
68Circadian rhythm_Homo sapiens_hsa047100.62683499
69Influenza A_Homo sapiens_hsa051640.61535792
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.59759709
71Adherens junction_Homo sapiens_hsa045200.58983521
72Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.56441380
73Viral myocarditis_Homo sapiens_hsa054160.55490843
74Small cell lung cancer_Homo sapiens_hsa052220.54314413
75Autoimmune thyroid disease_Homo sapiens_hsa053200.53940741
76TGF-beta signaling pathway_Homo sapiens_hsa043500.53580607
77Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.52768723
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51877757
79Biosynthesis of amino acids_Homo sapiens_hsa012300.50289396
80Glutathione metabolism_Homo sapiens_hsa004800.48877179
81Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46371710
82Hepatitis B_Homo sapiens_hsa051610.45755557
83Pentose phosphate pathway_Homo sapiens_hsa000300.45575197
84Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45409770
85TNF signaling pathway_Homo sapiens_hsa046680.45314637
86Vitamin B6 metabolism_Homo sapiens_hsa007500.44842573
87Primary immunodeficiency_Homo sapiens_hsa053400.44521789
88Jak-STAT signaling pathway_Homo sapiens_hsa046300.43877145
89T cell receptor signaling pathway_Homo sapiens_hsa046600.42992885
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42394056
91Starch and sucrose metabolism_Homo sapiens_hsa005000.42346386
92Oocyte meiosis_Homo sapiens_hsa041140.40206062
93Folate biosynthesis_Homo sapiens_hsa007900.39768302
94MicroRNAs in cancer_Homo sapiens_hsa052060.38684354
95Thyroid cancer_Homo sapiens_hsa052160.38368074
96Oxidative phosphorylation_Homo sapiens_hsa001900.38162272
97Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.38146715
98Ribosome_Homo sapiens_hsa030100.37999363
992-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.34063469
100Sphingolipid metabolism_Homo sapiens_hsa006000.34020466

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