C10ORF10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The expression of this gene is induced by fasting as well as by progesterone. The protein encoded by this gene contains a t-synaptosome-associated protein receptor (SNARE) coiled-coil homology domain and a peroxisomal targeting signal. Production of the encoded protein leads to phosphorylation and activation of the transcription factor ELK1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of complement activation (GO:0045916)4.05170730
2negative regulation of protein activation cascade (GO:2000258)3.90522524
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.50606110
4L-phenylalanine catabolic process (GO:0006559)3.50606110
5endothelium development (GO:0003158)3.50120674
6regulation of extracellular matrix disassembly (GO:0010715)3.40483069
7peptidyl-glutamic acid carboxylation (GO:0017187)3.40468457
8protein carboxylation (GO:0018214)3.40468457
9regulation of complement activation (GO:0030449)3.40457492
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.39159629
11L-phenylalanine metabolic process (GO:0006558)3.39159629
12transcytosis (GO:0045056)3.34637195
13regulation of protein activation cascade (GO:2000257)3.28891365
14regulation of type B pancreatic cell apoptotic process (GO:2000674)3.27636586
15positive regulation of glycolytic process (GO:0045821)3.24588472
16keratan sulfate catabolic process (GO:0042340)3.14970885
17endocrine hormone secretion (GO:0060986)3.14446773
18regulation of fibrinolysis (GO:0051917)3.06743267
19intestinal cholesterol absorption (GO:0030299)3.05711054
20negative regulation of humoral immune response (GO:0002921)2.91487925
21ovulation from ovarian follicle (GO:0001542)2.89535941
22growth hormone secretion (GO:0030252)2.86238502
23positive regulation of calcium ion import (GO:0090280)2.86117121
24ethanol oxidation (GO:0006069)2.82127914
25complement activation, alternative pathway (GO:0006957)2.80198709
26regulation of plasminogen activation (GO:0010755)2.79629913
27fatty acid homeostasis (GO:0055089)2.78876786
28peptide hormone processing (GO:0016486)2.75217365
29blood coagulation, intrinsic pathway (GO:0007597)2.71474172
30regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.70839528
31triglyceride homeostasis (GO:0070328)2.68046299
32acylglycerol homeostasis (GO:0055090)2.68046299
33regulation of cholesterol esterification (GO:0010872)2.67162613
34blood vessel maturation (GO:0001955)2.64213415
35low-density lipoprotein particle clearance (GO:0034383)2.64129821
36reverse cholesterol transport (GO:0043691)2.62956028
37retinol metabolic process (GO:0042572)2.60509666
38macroautophagy (GO:0016236)2.59544735
39peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.59355231
40epithelial cell fate commitment (GO:0072148)2.56962491
41retina vasculature morphogenesis in camera-type eye (GO:0061299)2.55434437
42positive regulation of glomerulus development (GO:0090193)2.53947254
43low-density lipoprotein particle remodeling (GO:0034374)2.52540871
44protein-lipid complex remodeling (GO:0034368)2.52335035
45macromolecular complex remodeling (GO:0034367)2.52335035
46plasma lipoprotein particle remodeling (GO:0034369)2.52335035
47cell proliferation involved in kidney development (GO:0072111)2.47870629
48triglyceride catabolic process (GO:0019433)2.45570161
49artery smooth muscle contraction (GO:0014824)2.44227979
50acylglycerol catabolic process (GO:0046464)2.42020420
51neutral lipid catabolic process (GO:0046461)2.42020420
52positive regulation of steroid metabolic process (GO:0045940)2.41993992
53detection of calcium ion (GO:0005513)2.41304733
54complement activation, classical pathway (GO:0006958)2.39896322
55regulation of lipoprotein metabolic process (GO:0050746)2.39746361
56tonic smooth muscle contraction (GO:0014820)2.38897396
57lymphangiogenesis (GO:0001946)2.37967077
58nitric oxide mediated signal transduction (GO:0007263)2.37223085
59regulation of sequestering of triglyceride (GO:0010889)2.35989158
60plasma lipoprotein particle clearance (GO:0034381)2.35770367
61insulin secretion (GO:0030073)2.34577593
62cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.33703388
63adult feeding behavior (GO:0008343)2.32472482
64response to dietary excess (GO:0002021)2.30891130
65protein activation cascade (GO:0072376)2.30582916
66glycerolipid catabolic process (GO:0046503)2.30076406
67regulation of apoptotic cell clearance (GO:2000425)2.29983458
68negative regulation of protein autophosphorylation (GO:0031953)2.29222146
69negative regulation of fibrinolysis (GO:0051918)2.28892160
70cellular zinc ion homeostasis (GO:0006882)2.27584576
71vascular endothelial growth factor signaling pathway (GO:0038084)2.27358433
72negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.26712642
73high-density lipoprotein particle remodeling (GO:0034375)2.26581896
74nephron tubule morphogenesis (GO:0072078)2.26155679
75nephron epithelium morphogenesis (GO:0072088)2.26155679
76negative regulation of execution phase of apoptosis (GO:1900118)2.25359293
77nitric oxide biosynthetic process (GO:0006809)2.24576000
78positive regulation of transforming growth factor beta production (GO:0071636)2.24364824
79ethanol metabolic process (GO:0006067)2.23527406
80primary alcohol metabolic process (GO:0034308)2.22950544
81regulation of cholesterol homeostasis (GO:2000188)2.21097115
82regulation of integrin-mediated signaling pathway (GO:2001044)2.19911726
83peptide hormone secretion (GO:0030072)2.19714981
84peptide secretion (GO:0002790)2.19037277
85mesenchymal cell differentiation involved in kidney development (GO:0072161)2.18884534
86mesenchymal cell differentiation involved in renal system development (GO:2001012)2.18884534
87regulation of extracellular matrix organization (GO:1903053)2.18655201
88positive regulation of insulin secretion (GO:0032024)2.15577216
89positive regulation of lipoprotein lipase activity (GO:0051006)2.15323489
90positive regulation of triglyceride lipase activity (GO:0061365)2.15323489
91cellular response to cadmium ion (GO:0071276)2.15218046
92cell volume homeostasis (GO:0006884)2.14784453
93complement activation (GO:0006956)2.14186020
94triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.13740627
95regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.12532462
96positive regulation of steroid biosynthetic process (GO:0010893)2.11943834
97cellular ketone body metabolic process (GO:0046950)2.11932158
98regulation of corticosteroid hormone secretion (GO:2000846)2.11639071
99positive regulation of steroid hormone secretion (GO:2000833)2.11618674
100renal tubule morphogenesis (GO:0061333)2.10911972

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.48999780
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.07370769
3TRIM28_21343339_ChIP-Seq_HEK293_Human2.93296410
4RXR_22158963_ChIP-Seq_LIVER_Mouse2.48379162
5LXR_22158963_ChIP-Seq_LIVER_Mouse2.38844875
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.36265440
7CDX2_19796622_ChIP-Seq_MESCs_Mouse2.32056538
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.25540524
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.06469044
10RARG_19884340_ChIP-ChIP_MEFs_Mouse1.92565230
11GATA2_21666600_ChIP-Seq_HMVEC_Human1.86154099
12ESR2_21235772_ChIP-Seq_MCF-7_Human1.85282774
13PPARA_22158963_ChIP-Seq_LIVER_Mouse1.84905414
14ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.76186947
15FOXA2_19822575_ChIP-Seq_HepG2_Human1.71433648
16ZNF217_24962896_ChIP-Seq_MCF-7_Human1.69776029
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.68462388
18EP300_21415370_ChIP-Seq_HL-1_Mouse1.67421604
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.57474551
20* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.52857338
21SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.51733776
22PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.51060867
23CJUN_26792858_Chip-Seq_BT549_Human1.50623999
24ESR1_21235772_ChIP-Seq_MCF-7_Human1.50245070
25MTF2_20144788_ChIP-Seq_MESCs_Mouse1.49881144
26ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.44959441
27EGR1_23403033_ChIP-Seq_LIVER_Mouse1.44883317
28SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.43529941
29SMAD_19615063_ChIP-ChIP_OVARY_Human1.41030726
30HIF1A_21447827_ChIP-Seq_MCF-7_Human1.39823268
31SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.39175840
32* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.39132158
33SOX2_20726797_ChIP-Seq_SW620_Human1.38216651
34CLOCK_20551151_ChIP-Seq_293T_Human1.38024595
35FOXO3_23340844_ChIP-Seq_DLD1_Human1.36941242
36SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.35985086
37TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.28339775
38PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.27038870
39EED_16625203_ChIP-ChIP_MESCs_Mouse1.25123228
40PIAS1_25552417_ChIP-Seq_VCAP_Human1.24111478
41EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.23768938
42GBX2_23144817_ChIP-Seq_PC3_Human1.23071077
43TBX20_22080862_ChIP-Seq_HEART_Mouse1.19496706
44TBX20_22328084_ChIP-Seq_HEART_Mouse1.19496706
45TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18558523
46TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16652522
47SALL4_18804426_ChIP-ChIP_XEN_Mouse1.16500327
48WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14902879
49NR3C1_23031785_ChIP-Seq_PC12_Mouse1.13960599
50EZH2_18974828_ChIP-Seq_MESCs_Mouse1.12218087
51RNF2_18974828_ChIP-Seq_MESCs_Mouse1.12218087
52NFIB_24661679_ChIP-Seq_LUNG_Mouse1.08316688
53CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.07761778
54CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.03394700
55JARID2_20075857_ChIP-Seq_MESCs_Mouse1.02380822
56AHR_22903824_ChIP-Seq_MCF-7_Human1.02016188
57BCAT_22108803_ChIP-Seq_LS180_Human1.01722114
58* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.01720231
59SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.00616893
60AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99774035
61ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99497018
62PPAR_26484153_Chip-Seq_NCI-H1993_Human0.98020415
63RAD21_21589869_ChIP-Seq_MESCs_Mouse0.97318958
64FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96320743
65PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.94849748
66ARNT_22903824_ChIP-Seq_MCF-7_Human0.92498158
67FOXA1_25552417_ChIP-Seq_VCAP_Human0.92120259
68HNF4A_19822575_ChIP-Seq_HepG2_Human0.90694325
69GATA4_25053715_ChIP-Seq_YYC3_Human0.87611813
70ZFP57_27257070_Chip-Seq_ESCs_Mouse0.87546453
71SMAD4_21799915_ChIP-Seq_A2780_Human0.86357336
72CDX2_22108803_ChIP-Seq_LS180_Human0.84908250
73DROSHA_22980978_ChIP-Seq_HELA_Human0.84557387
74NR3C1_21868756_ChIP-Seq_MCF10A_Human0.82471523
75SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.81733758
76IKZF1_21737484_ChIP-ChIP_HCT116_Human0.81054067
77AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.80637991
78SOX9_24532713_ChIP-Seq_HFSC_Mouse0.80611452
79SUZ12_27294783_Chip-Seq_ESCs_Mouse0.80533582
80EZH2_27294783_Chip-Seq_ESCs_Mouse0.80527612
81NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.80439792
82NRF2_20460467_ChIP-Seq_MEFs_Mouse0.80439792
83JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80427951
84SOX2_27498859_Chip-Seq_STOMACH_Mouse0.79900601
85SMAD3_21741376_ChIP-Seq_HESCs_Human0.78986907
86SMAD4_21741376_ChIP-Seq_HESCs_Human0.78238493
87CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.77863629
88PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.77583670
89Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.76898360
90SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.76441879
91CDX2_20551321_ChIP-Seq_CACO-2_Human0.75311746
92SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.73154533
93CTNNB1_20460455_ChIP-Seq_HCT116_Human0.73084461
94TCF4_18268006_ChIP-ChIP_LS174T_Human0.73032419
95RNF2_27304074_Chip-Seq_ESCs_Mouse0.72795746
96RING1B_27294783_Chip-Seq_ESCs_Mouse0.71215255
97P63_26484246_Chip-Seq_KERATINOCYTES_Human0.70824484
98SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70704792
99AR_25329375_ChIP-Seq_VCAP_Human0.70603859
100JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.70184398

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009780_abnormal_chondrocyte_physiolo4.29889774
2MP0003011_delayed_dark_adaptation3.62284062
3MP0010368_abnormal_lymphatic_system3.29937405
4MP0005670_abnormal_white_adipose3.23550086
5MP0000013_abnormal_adipose_tissue2.99762464
6MP0002139_abnormal_hepatobiliary_system2.84192710
7MP0010329_abnormal_lipoprotein_level2.63117886
8MP0005167_abnormal_blood-brain_barrier2.61801254
9MP0005365_abnormal_bile_salt2.60482853
10MP0008438_abnormal_cutaneous_collagen2.52611016
11MP0003195_calcinosis2.49113058
12MP0002876_abnormal_thyroid_physiology2.32130741
13MP0004272_abnormal_basement_membrane2.28998517
14MP0002909_abnormal_adrenal_gland2.19750319
15MP0000003_abnormal_adipose_tissue2.13195041
16MP0001879_abnormal_lymphatic_vessel2.02537163
17MP0005379_endocrine/exocrine_gland_phen2.00021378
18MP0002295_abnormal_pulmonary_circulatio1.97745207
19MP0002837_dystrophic_cardiac_calcinosis1.95659613
20MP0004019_abnormal_vitamin_homeostasis1.90339692
21MP0005503_abnormal_tendon_morphology1.89447734
22MP0002933_joint_inflammation1.88475288
23MP0005275_abnormal_skin_tensile1.79047657
24MP0001944_abnormal_pancreas_morphology1.76626586
25MP0003724_increased_susceptibility_to1.70756096
26MP0002971_abnormal_brown_adipose1.68864107
27MP0003868_abnormal_feces_composition1.68469981
28MP0005375_adipose_tissue_phenotype1.61201786
29MP0001756_abnormal_urination1.54506798
30MP0003279_aneurysm1.54429508
31MP0006054_spinal_hemorrhage1.49012382
32MP0001661_extended_life_span1.48518573
33MP0009840_abnormal_foam_cell1.46741992
34MP0005332_abnormal_amino_acid1.45040636
35MP0002118_abnormal_lipid_homeostasis1.42307829
36MP0002078_abnormal_glucose_homeostasis1.38907518
37MP0010386_abnormal_urinary_bladder1.38792693
38MP0005448_abnormal_energy_balance1.37757537
39MP0003122_maternal_imprinting1.35085623
40MP0002693_abnormal_pancreas_physiology1.33424794
41MP0005084_abnormal_gallbladder_morpholo1.33321713
42MP0010234_abnormal_vibrissa_follicle1.33164508
43MP0002638_abnormal_pupillary_reflex1.28522590
44MP0002138_abnormal_hepatobiliary_system1.26905247
45MP0000767_abnormal_smooth_muscle1.24324255
46MP0005360_urolithiasis1.23430900
47MP0001958_emphysema1.22584644
48MP0003690_abnormal_glial_cell1.22226592
49MP0001501_abnormal_sleep_pattern1.21981394
50MP0005058_abnormal_lysosome_morphology1.19823135
51MP0001666_abnormal_nutrient_absorption1.19361141
52MP0005220_abnormal_exocrine_pancreas1.18284039
53MP0005646_abnormal_pituitary_gland1.17820974
54MP0005535_abnormal_body_temperature1.17322289
55MP0002108_abnormal_muscle_morphology1.15642255
56MP0005666_abnormal_adipose_tissue1.14322401
57MP0005595_abnormal_vascular_smooth1.12017789
58MP0003879_abnormal_hair_cell1.09174617
59MP0002254_reproductive_system_inflammat1.07979441
60MP0004130_abnormal_muscle_cell1.07479718
61MP0005164_abnormal_response_to1.05920856
62MP0003172_abnormal_lysosome_physiology1.04261694
63MP0005551_abnormal_eye_electrophysiolog1.03073422
64MP0000751_myopathy1.01017509
65MP0009115_abnormal_fat_cell0.98616713
66MP0004215_abnormal_myocardial_fiber0.95314181
67MP0009643_abnormal_urine_homeostasis0.95170124
68MP0008775_abnormal_heart_ventricle0.94611256
69MP0000249_abnormal_blood_vessel0.93937928
70MP0003953_abnormal_hormone_level0.93544254
71MP0003075_altered_response_to0.91564191
72MP0003045_fibrosis0.90004752
73MP0005165_increased_susceptibility_to0.89349745
74MP0001502_abnormal_circadian_rhythm0.88568470
75MP0006138_congestive_heart_failure0.88528781
76MP0003633_abnormal_nervous_system0.88113903
77MP0003329_amyloid_beta_deposits0.87279224
78MP0002970_abnormal_white_adipose0.81670563
79MP0000230_abnormal_systemic_arterial0.80210889
80MP0004085_abnormal_heartbeat0.79808083
81MP0005334_abnormal_fat_pad0.79296037
82MP0005452_abnormal_adipose_tissue0.79008871
83MP0005636_abnormal_mineral_homeostasis0.78247647
84MP0005257_abnormal_intraocular_pressure0.77325563
85MP0008875_abnormal_xenobiotic_pharmacok0.76738134
86MP0005085_abnormal_gallbladder_physiolo0.76196546
87MP0003566_abnormal_cell_adhesion0.74962857
88MP0000639_abnormal_adrenal_gland0.74780458
89MP0005023_abnormal_wound_healing0.74623211
90MP0002168_other_aberrant_phenotype0.74443429
91MP0004084_abnormal_cardiac_muscle0.74246483
92MP0004510_myositis0.73539735
93MP0002896_abnormal_bone_mineralization0.71105329
94MP0003959_abnormal_lean_body0.69942601
95MP0002163_abnormal_gland_morphology0.69926713
96MP0004036_abnormal_muscle_relaxation0.68247056
97MP0005253_abnormal_eye_physiology0.67748880
98MP0002972_abnormal_cardiac_muscle0.67476795
99MP0000343_altered_response_to0.66925287
100MP0009046_muscle_twitch0.66835034

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)4.98127798
2Complement deficiency (HP:0004431)4.93073923
3Systemic lupus erythematosus (HP:0002725)3.99680748
4Abnormality of complement system (HP:0005339)3.92521581
5Xanthomatosis (HP:0000991)3.83089187
6Hypoglycemic coma (HP:0001325)3.56865921
7Joint hemorrhage (HP:0005261)3.54686644
8Increased CSF protein (HP:0002922)3.39766144
9Urinary glycosaminoglycan excretion (HP:0003541)3.34275093
10Mucopolysacchariduria (HP:0008155)3.34275093
11Abnormality of mucopolysaccharide metabolism (HP:0011020)3.29932040
12Abnormality of polysaccharide metabolism (HP:0011012)3.29932040
13Abnormality of glycosaminoglycan metabolism (HP:0004371)3.29932040
14Hyperglycemia (HP:0003074)3.25973080
15Hematochezia (HP:0002573)3.24815082
16Glomerulonephritis (HP:0000099)3.18567610
17Hypoglycemic seizures (HP:0002173)3.15945583
18Deep venous thrombosis (HP:0002625)3.06440077
19Protrusio acetabuli (HP:0003179)3.05099090
20Vascular calcification (HP:0004934)3.01624639
21Insulin-resistant diabetes mellitus (HP:0000831)2.97630650
22Pigmentary retinal degeneration (HP:0001146)2.97326573
23Enlarged penis (HP:0000040)2.90362267
24Cardiovascular calcification (HP:0011915)2.88869425
25Nuclear cataract (HP:0100018)2.85607230
26Prolonged partial thromboplastin time (HP:0003645)2.82116591
27Hyperinsulinemic hypoglycemia (HP:0000825)2.80057640
28Ketoacidosis (HP:0001993)2.78653030
29Hyperlipoproteinemia (HP:0010980)2.77792838
30Mitral stenosis (HP:0001718)2.66032176
31Growth hormone excess (HP:0000845)2.54932972
32Epidermoid cyst (HP:0200040)2.52381715
33Steatorrhea (HP:0002570)2.50793822
34Oligomenorrhea (HP:0000876)2.50445717
35Lymphangioma (HP:0100764)2.49172532
36Acanthosis nigricans (HP:0000956)2.47262218
37Skin nodule (HP:0200036)2.46846665
38Dysostosis multiplex (HP:0000943)2.42815052
39Fat malabsorption (HP:0002630)2.41008659
40Insulin resistance (HP:0000855)2.36831022
41Striae distensae (HP:0001065)2.31177806
42Bone cyst (HP:0012062)2.22064342
43Hypoalphalipoproteinemia (HP:0003233)2.13532149
44Esophageal varix (HP:0002040)2.13139074
45Cerebral aneurysm (HP:0004944)2.12851823
46Myocardial infarction (HP:0001658)2.12808686
47Postural tremor (HP:0002174)2.11652190
48Aortic aneurysm (HP:0004942)2.11418496
49Asymmetric septal hypertrophy (HP:0001670)2.10953394
50Late onset (HP:0003584)2.10686035
51Hemorrhage of the eye (HP:0011885)2.09687006
52Nephritis (HP:0000123)2.04040581
53Hydroxyprolinuria (HP:0003080)2.03855784
54Abnormality of proline metabolism (HP:0010907)2.03855784
55Vascular tortuosity (HP:0004948)2.02302296
56Large for gestational age (HP:0001520)1.98076151
57Potter facies (HP:0002009)1.97542678
58Facial shape deformation (HP:0011334)1.97542678
59Hypercholesterolemia (HP:0003124)1.96359324
60Progressive neurologic deterioration (HP:0002344)1.96255458
61Vertebral compression fractures (HP:0002953)1.93521536
62Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.93255777
63Stroke (HP:0001297)1.91562292
64Amyloidosis (HP:0011034)1.90899691
65Menorrhagia (HP:0000132)1.85861849
66Increased variability in muscle fiber diameter (HP:0003557)1.85785832
67Ketosis (HP:0001946)1.85520115
68Joint stiffness (HP:0001387)1.85334247
69Hypolipoproteinemia (HP:0010981)1.84299875
70Symptomatic seizures (HP:0011145)1.83780778
71Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.82441611
72Zonular cataract (HP:0010920)1.81212190
73Congenital sensorineural hearing impairment (HP:0008527)1.80520866
74Exocrine pancreatic insufficiency (HP:0001738)1.80455449
75Abnormality of the pancreatic islet cells (HP:0006476)1.80179056
76Abnormality of endocrine pancreas physiology (HP:0012093)1.80179056
77Right ventricular cardiomyopathy (HP:0011663)1.79177732
78Hypothermia (HP:0002045)1.78684154
79Pancreatic islet-cell hyperplasia (HP:0004510)1.78170805
80Polar cataract (HP:0010696)1.77990668
81Cervical subluxation (HP:0003308)1.77808661
82Congenital stationary night blindness (HP:0007642)1.77659363
83Arterial tortuosity (HP:0005116)1.76932125
84Prominent supraorbital ridges (HP:0000336)1.75577976
85Testicular neoplasm (HP:0010788)1.75442750
86Polycythemia (HP:0001901)1.74847741
87Abnormality of the common coagulation pathway (HP:0010990)1.74401445
88Beaking of vertebral bodies (HP:0004568)1.73456927
89Muscle fiber splitting (HP:0003555)1.73333327
90Episodic fever (HP:0001954)1.72861387
91Abnormality of vitamin metabolism (HP:0100508)1.72263106
92Hypertriglyceridemia (HP:0002155)1.71377457
93Action tremor (HP:0002345)1.71245188
94Abnormality of the intrinsic pathway (HP:0010989)1.70945525
95Glucose intolerance (HP:0000833)1.69579171
96Bradycardia (HP:0001662)1.67875032
97Visceral angiomatosis (HP:0100761)1.66061018
98Hemiparesis (HP:0001269)1.66020382
99Abnormality of glycosphingolipid metabolism (HP:0004343)1.63246241
100Abnormality of glycolipid metabolism (HP:0010969)1.63246241

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.93896138
2FRK3.94878077
3GRK13.03479096
4FGFR32.43503500
5INSRR2.36496705
6TGFBR22.32325776
7FGFR22.30521457
8TRPM72.24888060
9EPHA32.23322703
10FER2.19537983
11ERN12.19013501
12MYLK2.12844532
13FGFR42.11642574
14RIPK11.98973026
15MAPKAPK31.93552990
16PHKG11.78224726
17PHKG21.78224726
18NTRK31.65920679
19NLK1.59495305
20PRKAA21.59350943
21DAPK21.52930632
22MAP3K21.45206493
23MAP3K31.44405218
24EPHB11.41475534
25DDR21.16938966
26MAP2K61.14630498
27HIPK21.14509648
28WNK41.12215999
29LMTK21.10208785
30PTK2B1.08170159
31PDGFRA1.07970716
32PTK21.06207588
33STK241.01968175
34MAP3K71.01681323
35CDC42BPA0.99132924
36SIK10.95277120
37EPHB20.92938050
38STK30.90515487
39PAK30.89126359
40PRKD30.86881318
41STK38L0.86826983
42SGK4940.86155877
43SGK2230.86155877
44ADRBK20.86122474
45PINK10.86085137
46EEF2K0.84748220
47PRKAA10.84367085
48MAP4K20.82679634
49PRKG20.80867104
50GRK50.80568476
51CAMK2D0.75931319
52MARK20.74409639
53PRKCE0.74199884
54MAP3K90.71139461
55MAPK150.67776730
56MST40.67017683
57SGK20.66929759
58JAK10.66621224
59TESK10.66168444
60GSK3A0.65714910
61KDR0.65533300
62MAP3K10.65180749
63STK380.63867356
64PRKD10.62570015
65WNK10.61330580
66TTN0.57131223
67ADRBK10.54306566
68EPHA20.53082493
69IRAK10.52715968
70MAPK120.51526704
71STK390.51435062
72CAMK10.51370226
73PRKD20.51363770
74ROCK10.51131323
75MAP3K120.50177183
76MAP2K10.50035726
77TNK20.49872282
78PRKG10.48936887
79MAPK70.47709080
80SGK30.46445506
81PIK3CA0.45814315
82BMPR1B0.45583212
83PDPK10.44562408
84KIT0.44351383
85RPS6KA20.44189437
86ACVR1B0.44053691
87LATS20.41330788
88LIMK10.39070382
89FES0.38525287
90PDGFRB0.38251403
91MAPK110.38091470
92MET0.37356955
93ABL20.36614680
94MAP3K60.34080885
95ROCK20.33728018
96TYK20.31188185
97DAPK30.31108584
98DMPK0.30782430
99CAMK2G0.30428969
100AKT20.29016130

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.59383916
2Complement and coagulation cascades_Homo sapiens_hsa046103.29093376
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.11884025
4Glycosaminoglycan degradation_Homo sapiens_hsa005312.11605790
5Sulfur metabolism_Homo sapiens_hsa009202.10343588
6Other glycan degradation_Homo sapiens_hsa005111.88437997
7PPAR signaling pathway_Homo sapiens_hsa033201.82897825
8Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.80970199
9Arginine biosynthesis_Homo sapiens_hsa002201.75636696
10Fat digestion and absorption_Homo sapiens_hsa049751.75561918
11Histidine metabolism_Homo sapiens_hsa003401.73685737
12Folate biosynthesis_Homo sapiens_hsa007901.72511627
13Butanoate metabolism_Homo sapiens_hsa006501.65725537
14Circadian rhythm_Homo sapiens_hsa047101.61849819
15Fatty acid degradation_Homo sapiens_hsa000711.57046375
16Insulin secretion_Homo sapiens_hsa049111.54290050
17Phenylalanine metabolism_Homo sapiens_hsa003601.51996601
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.50816672
19Tryptophan metabolism_Homo sapiens_hsa003801.49568409
20ABC transporters_Homo sapiens_hsa020101.47778720
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.34145838
22Mineral absorption_Homo sapiens_hsa049781.27974636
23Retinol metabolism_Homo sapiens_hsa008301.22845723
24Protein digestion and absorption_Homo sapiens_hsa049741.21786653
25Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.21325123
26Pancreatic secretion_Homo sapiens_hsa049721.20967175
27Glycerolipid metabolism_Homo sapiens_hsa005611.16235218
28Tyrosine metabolism_Homo sapiens_hsa003501.15847574
29ECM-receptor interaction_Homo sapiens_hsa045121.15703171
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.10173906
31Ovarian steroidogenesis_Homo sapiens_hsa049131.09978043
32Renin secretion_Homo sapiens_hsa049241.08356878
33Primary bile acid biosynthesis_Homo sapiens_hsa001201.07701606
34Bile secretion_Homo sapiens_hsa049761.07406588
35Vitamin B6 metabolism_Homo sapiens_hsa007500.99391653
36beta-Alanine metabolism_Homo sapiens_hsa004100.96784039
37Fatty acid elongation_Homo sapiens_hsa000620.96465252
38Insulin resistance_Homo sapiens_hsa049310.95037239
39Adipocytokine signaling pathway_Homo sapiens_hsa049200.94984455
40Sphingolipid metabolism_Homo sapiens_hsa006000.94580484
41Cyanoamino acid metabolism_Homo sapiens_hsa004600.93173384
42Vascular smooth muscle contraction_Homo sapiens_hsa042700.92287838
43Arginine and proline metabolism_Homo sapiens_hsa003300.91034909
44Arachidonic acid metabolism_Homo sapiens_hsa005900.88764684
45Fatty acid metabolism_Homo sapiens_hsa012120.85115031
46Phototransduction_Homo sapiens_hsa047440.84681627
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.83618363
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.83602097
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83381866
50Pentose and glucuronate interconversions_Homo sapiens_hsa000400.82576799
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81479648
52Lysosome_Homo sapiens_hsa041420.81303907
53Chemical carcinogenesis_Homo sapiens_hsa052040.79612593
54Glucagon signaling pathway_Homo sapiens_hsa049220.78852947
55Selenocompound metabolism_Homo sapiens_hsa004500.78803528
56Collecting duct acid secretion_Homo sapiens_hsa049660.77198943
57Peroxisome_Homo sapiens_hsa041460.76813381
58Starch and sucrose metabolism_Homo sapiens_hsa005000.75548188
59AMPK signaling pathway_Homo sapiens_hsa041520.75291961
60Thyroid hormone synthesis_Homo sapiens_hsa049180.74172603
61Fatty acid biosynthesis_Homo sapiens_hsa000610.73727865
62Staphylococcus aureus infection_Homo sapiens_hsa051500.72910477
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72709218
64Propanoate metabolism_Homo sapiens_hsa006400.69537319
65Pertussis_Homo sapiens_hsa051330.69497543
66Prion diseases_Homo sapiens_hsa050200.69039777
67Ether lipid metabolism_Homo sapiens_hsa005650.68931326
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68765767
69Aldosterone synthesis and secretion_Homo sapiens_hsa049250.68335615
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.66526789
71Type II diabetes mellitus_Homo sapiens_hsa049300.66493989
72Vitamin digestion and absorption_Homo sapiens_hsa049770.66307924
73Vibrio cholerae infection_Homo sapiens_hsa051100.63914433
74Glutathione metabolism_Homo sapiens_hsa004800.63793493
75Focal adhesion_Homo sapiens_hsa045100.63666748
76Renin-angiotensin system_Homo sapiens_hsa046140.63177187
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62177035
78cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61289089
79Linoleic acid metabolism_Homo sapiens_hsa005910.58223824
80Dorso-ventral axis formation_Homo sapiens_hsa043200.58107291
81GABAergic synapse_Homo sapiens_hsa047270.56968021
82Dilated cardiomyopathy_Homo sapiens_hsa054140.52678326
83Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.51972282
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51548127
85Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.50397568
86Circadian entrainment_Homo sapiens_hsa047130.49694471
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49144683
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49017127
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.45660048
90Nitrogen metabolism_Homo sapiens_hsa009100.45041539
91AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41593127
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40743100
93cAMP signaling pathway_Homo sapiens_hsa040240.40440039
94Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.39869434
95Insulin signaling pathway_Homo sapiens_hsa049100.39594490
96Salivary secretion_Homo sapiens_hsa049700.39008227
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38458362
98Fructose and mannose metabolism_Homo sapiens_hsa000510.38221697
99Serotonergic synapse_Homo sapiens_hsa047260.37227682
100Malaria_Homo sapiens_hsa051440.35918255

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