C10ORF105

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.82241841
2modulation by symbiont of host immune response (GO:0052553)6.53372332
3positive regulation by symbiont of host defense response (GO:0052509)6.53372332
4modulation by symbiont of host defense response (GO:0052031)6.53372332
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.53372332
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.53372332
7positive regulation by organism of defense response of other organism involved in symbiotic interact6.53372332
8negative regulation of cell killing (GO:0031342)6.22955954
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.22955954
10positive regulation of gamma-delta T cell activation (GO:0046645)5.38971774
11macrophage activation involved in immune response (GO:0002281)5.32645784
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.28960456
13neutrophil activation involved in immune response (GO:0002283)5.14888704
14antigen processing and presentation of endogenous antigen (GO:0019883)5.13794164
15detection of other organism (GO:0098543)5.11061810
16detection of molecule of bacterial origin (GO:0032490)4.94662890
17detection of bacterium (GO:0016045)4.77774267
18regulation of B cell receptor signaling pathway (GO:0050855)4.75911008
19cellular extravasation (GO:0045123)4.73524225
20response to peptidoglycan (GO:0032494)4.71210864
21positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.69834343
22antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.67323753
23detection of external biotic stimulus (GO:0098581)4.62314834
24regulation of interferon-beta biosynthetic process (GO:0045357)4.61931115
25response to host immune response (GO:0052572)4.48970491
26response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.48970491
27microglial cell activation (GO:0001774)4.48240906
28leukocyte migration involved in inflammatory response (GO:0002523)4.42723351
29negative regulation of lymphocyte mediated immunity (GO:0002707)4.35182648
30neutrophil activation (GO:0042119)4.30795718
31leukocyte aggregation (GO:0070486)4.21626820
32negative regulation of interleukin-12 production (GO:0032695)4.20052905
33respiratory burst (GO:0045730)4.13603157
34response to interleukin-15 (GO:0070672)4.12401898
35response to host defenses (GO:0052200)4.11250002
36response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.11250002
37response to host (GO:0075136)4.11250002
38detection of biotic stimulus (GO:0009595)4.06081958
39positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.04184591
40regulation of gamma-delta T cell activation (GO:0046643)4.02393870
41regulation of T-helper 2 cell differentiation (GO:0045628)3.98778508
42negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.95374223
43macrophage activation (GO:0042116)3.94915291
44neutrophil mediated immunity (GO:0002446)3.93895216
45negative regulation of leukocyte mediated immunity (GO:0002704)3.87775793
46cellular response to interleukin-15 (GO:0071350)3.83561989
47granulocyte activation (GO:0036230)3.83514481
48myeloid cell activation involved in immune response (GO:0002275)3.83273326
49regulation of mast cell degranulation (GO:0043304)3.76825756
50negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.65687102
51regulation of myeloid leukocyte mediated immunity (GO:0002886)3.57925035
52positive regulation of mast cell activation (GO:0033005)3.57493372
53type I interferon signaling pathway (GO:0060337)3.53545100
54cellular response to type I interferon (GO:0071357)3.53545100
55immunoglobulin mediated immune response (GO:0016064)3.52910035
56response to type I interferon (GO:0034340)3.51855998
57regulation of gamma-delta T cell differentiation (GO:0045586)3.50668145
58regulation of mast cell activation involved in immune response (GO:0033006)3.47494644
59negative regulation of T cell mediated immunity (GO:0002710)3.46969646
60positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.44191661
61regulation of leukocyte degranulation (GO:0043300)3.40811753
62production of molecular mediator involved in inflammatory response (GO:0002532)3.35357227
63myeloid leukocyte mediated immunity (GO:0002444)3.28920493
64response to muramyl dipeptide (GO:0032495)3.26340847
65leukocyte degranulation (GO:0043299)3.25671808
66regulation of mast cell activation (GO:0033003)3.25000503
67negative regulation of T-helper cell differentiation (GO:0045623)3.20648989
68negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.20648989
69negative regulation of type 2 immune response (GO:0002829)3.20467983
70antigen processing and presentation via MHC class Ib (GO:0002475)3.20420045
71positive regulation of cellular amide metabolic process (GO:0034250)3.17110697
72germinal center formation (GO:0002467)3.15250847
73negative regulation of phagocytosis (GO:0050765)3.14862004
74B cell receptor signaling pathway (GO:0050853)3.10718478
75regulation of tolerance induction (GO:0002643)3.06293824
76regulation of T cell tolerance induction (GO:0002664)3.05946237
77positive regulation of mast cell degranulation (GO:0043306)3.03451465
78positive regulation of mast cell activation involved in immune response (GO:0033008)3.03451465
79regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.03437600
80positive regulation of toll-like receptor signaling pathway (GO:0034123)3.02111504
81activated T cell proliferation (GO:0050798)3.01939204
82regulation of regulated secretory pathway (GO:1903305)2.99924161
83defense response to protozoan (GO:0042832)2.99358182
84positive regulation of interferon-alpha production (GO:0032727)2.96981349
85dendritic cell chemotaxis (GO:0002407)2.96139065
86dendritic cell migration (GO:0036336)2.95281555
87negative regulation of interleukin-6 production (GO:0032715)2.92960024
88interferon-gamma-mediated signaling pathway (GO:0060333)2.91717994
89negative regulation of erythrocyte differentiation (GO:0045647)2.91695588
90regulation of B cell differentiation (GO:0045577)2.90799862
91tolerance induction (GO:0002507)2.88584572
92positive regulation of T cell mediated cytotoxicity (GO:0001916)2.87741516
93regulation of T cell mediated cytotoxicity (GO:0001914)2.87459328
94negative regulation of alpha-beta T cell activation (GO:0046636)2.86674403
95myeloid leukocyte activation (GO:0002274)2.85645911
96positive thymic T cell selection (GO:0045059)2.85223313
97positive regulation of type 2 immune response (GO:0002830)2.85155222
98regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.83555111
99regulation of type 2 immune response (GO:0002828)2.82549960
100neutrophil chemotaxis (GO:0030593)2.81902170

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.71417285
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.44250901
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.86331608
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.52509965
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.30961293
6IRF8_27001747_Chip-Seq_BMDM_Mouse2.88349243
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.82252396
8RUNX_20019798_ChIP-Seq_JUKART_Human2.81837379
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.79103597
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.70111366
11SPI1_23127762_ChIP-Seq_K562_Human2.65443598
12VDR_24763502_ChIP-Seq_THP-1_Human2.46221887
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.40934135
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.31744040
15SPI1_23547873_ChIP-Seq_NB4_Human2.29530172
16VDR_21846776_ChIP-Seq_THP-1_Human2.28394295
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.26312542
18SCL_19346495_ChIP-Seq_HPC-7_Human2.24959838
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.24915175
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.23861428
21VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.10008992
22E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.09867481
23KDM2B_26808549_Chip-Seq_SUP-B15_Human2.07671383
24MAF_26560356_Chip-Seq_TH1_Human2.05961728
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.04346180
26MYB_26560356_Chip-Seq_TH2_Human2.03018357
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.96532552
28UTX_26944678_Chip-Seq_JUKART_Human1.96413970
29RUNX1_22412390_ChIP-Seq_EML_Mouse1.93869636
30FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.91950377
31VDR_24787735_ChIP-Seq_THP-1_Human1.89198550
32TCF7_22412390_ChIP-Seq_EML_Mouse1.88571129
33SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.84075896
34KDM2B_26808549_Chip-Seq_DND41_Human1.80145291
35BRD4_27068464_Chip-Seq_AML-cells_Mouse1.78552599
36MYB_26560356_Chip-Seq_TH1_Human1.71078838
37Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.70993600
38NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.70349319
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.66987170
40STAT4_19710469_ChIP-ChIP_TH1__Mouse1.64965964
41* GATA3_27048872_Chip-Seq_THYMUS_Human1.61595158
42SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.61481137
43MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.61321748
44GATA1_19941827_ChIP-Seq_MEL_Mouse1.59564848
45MAF_26560356_Chip-Seq_TH2_Human1.56614548
46LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.54741727
47VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.53969316
48STAT6_21828071_ChIP-Seq_BEAS2B_Human1.51127325
49MYC_22102868_ChIP-Seq_BL_Human1.50669496
50KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.49038541
51TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.48073096
52* LXR_22292898_ChIP-Seq_THP-1_Human1.47770368
53CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.47162273
54KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.43567367
55IKZF1_21737484_ChIP-ChIP_HCT116_Human1.43381120
56GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.43181625
57LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.40902780
58GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.36726186
59PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33450028
60GATA1_19941826_ChIP-Seq_K562_Human1.31130121
61KDM2B_26808549_Chip-Seq_JURKAT_Human1.26769567
62PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25854349
63EGR1_19374776_ChIP-ChIP_THP-1_Human1.24496416
64GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.22988306
65CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21087852
66RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.19970573
67* BCL6_27268052_Chip-Seq_Bcells_Human1.17549148
68SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17380618
69DROSHA_22980978_ChIP-Seq_HELA_Human1.16399192
70NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.15507412
71ELK3_25401928_ChIP-Seq_HUVEC_Human1.14155984
72PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13907936
73BCOR_27268052_Chip-Seq_Bcells_Human1.12708445
74PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12456903
75CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10874713
76* GATA3_26560356_Chip-Seq_TH2_Human1.10737537
77GATA1_22383799_ChIP-Seq_G1ME_Mouse1.09165633
78PU_27001747_Chip-Seq_BMDM_Mouse1.07853363
79GATA2_22383799_ChIP-Seq_G1ME_Mouse1.07362080
80MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.05677322
81SPI1_20517297_ChIP-Seq_HL60_Human1.03956926
82CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03086381
83STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.02059363
84BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.01084963
85GATA2_21666600_ChIP-Seq_HMVEC_Human1.01048137
86GATA1_22025678_ChIP-Seq_K562_Human1.00755551
87GATA2_19941826_ChIP-Seq_K562_Human0.98985094
88SA1_27219007_Chip-Seq_ERYTHROID_Human0.95803006
89PU.1_20513432_ChIP-Seq_Bcells_Mouse0.95398664
90ELF1_20517297_ChIP-Seq_JURKAT_Human0.95271207
91KDM2B_26808549_Chip-Seq_K562_Human0.94157391
92CTCF_27219007_Chip-Seq_ERYTHROID_Human0.93104584
93FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.92936551
94SMC4_20622854_ChIP-Seq_HELA_Human0.91524585
95RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88581562
96SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.88444238
97TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87999844
98GATA1_19941827_ChIP-Seq_MEL86_Mouse0.87887097
99* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.86943817
100P68_20966046_ChIP-Seq_HELA_Human0.86428724

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to5.54169252
2MP0003436_decreased_susceptibility_to4.24761584
3MP0003303_peritoneal_inflammation3.85526647
4MP0001835_abnormal_antigen_presentation3.54823372
5MP0002419_abnormal_innate_immunity3.19632795
6MP0005025_abnormal_response_to2.82682046
7MP0005671_abnormal_response_to2.71601600
8MP0001800_abnormal_humoral_immune2.70808130
9MP0009785_altered_susceptibility_to2.63868155
10MP0005000_abnormal_immune_tolerance2.61278007
11MP0001790_abnormal_immune_system2.59804704
12MP0005387_immune_system_phenotype2.59804704
13MP0000685_abnormal_immune_system2.57643780
14MP0006082_CNS_inflammation2.55481195
15MP0002723_abnormal_immune_serum2.46938162
16MP0002132_abnormal_respiratory_system2.46331227
17MP0003300_gastrointestinal_ulcer2.41935847
18MP0002420_abnormal_adaptive_immunity2.38524336
19MP0001819_abnormal_immune_cell2.36050817
20MP0002452_abnormal_antigen_presenting2.32111888
21MP0001533_abnormal_skeleton_physiology2.31484976
22MP0005377_hearing/vestibular/ear_phenot2.16815805
23MP0003878_abnormal_ear_physiology2.16815805
24MP0008260_abnormal_autophagy2.12032431
25MP0003191_abnormal_cellular_cholesterol2.08092131
26MP0005464_abnormal_platelet_physiology2.01829800
27MP0002405_respiratory_system_inflammati1.96701716
28MP0002148_abnormal_hypersensitivity_rea1.92767977
29MP0009278_abnormal_bone_marrow1.86782326
30MP0005451_abnormal_body_composition1.84731934
31MP0003828_pulmonary_edema1.77250117
32MP0002398_abnormal_bone_marrow1.75870605
33MP0000716_abnormal_immune_system1.73643145
34MP0003172_abnormal_lysosome_physiology1.72731122
35MP0003763_abnormal_thymus_physiology1.71807931
36MP0005310_abnormal_salivary_gland1.57186048
37MP0003866_abnormal_defecation1.57087337
38MP0001845_abnormal_inflammatory_respons1.57060937
39MP0009764_decreased_sensitivity_to1.56167272
40MP0004947_skin_inflammation1.53100953
41MP0003690_abnormal_glial_cell1.52532777
42MP0002277_abnormal_respiratory_mucosa1.51526878
43MP0002396_abnormal_hematopoietic_system1.50552862
44MP0004883_abnormal_blood_vessel1.49225221
45MP0000465_gastrointestinal_hemorrhage1.47038716
46MP0004510_myositis1.46935712
47MP0010155_abnormal_intestine_physiology1.43112917
48MP0005410_abnormal_fertilization1.42793342
49MP0002722_abnormal_immune_system1.42531172
50MP0003183_abnormal_peptide_metabolism1.39197797
51MP0000689_abnormal_spleen_morphology1.38204759
52MP0003075_altered_response_to1.36343935
53MP0002429_abnormal_blood_cell1.32527525
54MP0008469_abnormal_protein_level1.31690459
55MP0000703_abnormal_thymus_morphology1.30850842
56MP0001851_eye_inflammation1.27525250
57MP0002998_abnormal_bone_remodeling1.26731648
58MP0004381_abnormal_hair_follicle1.22705544
59MP0001545_abnormal_hematopoietic_system1.20740342
60MP0005397_hematopoietic_system_phenotyp1.20740342
61MP0005164_abnormal_response_to1.15997615
62MP0008004_abnormal_stomach_pH1.14994473
63MP0009333_abnormal_splenocyte_physiolog1.11075458
64MP0005166_decreased_susceptibility_to1.08925131
65MP0000858_altered_metastatic_potential1.06260108
66MP0005390_skeleton_phenotype1.05074567
67MP0003879_abnormal_hair_cell0.99900046
68MP0001958_emphysema0.99285183
69MP0000604_amyloidosis0.93426731
70MP0003448_altered_tumor_morphology0.85053632
71MP0003045_fibrosis0.84976594
72MP0002653_abnormal_ependyma_morphology0.84116804
73MP0000343_altered_response_to0.83455088
74MP0003329_amyloid_beta_deposits0.82094252
75MP0005248_abnormal_Harderian_gland0.80632792
76MP0001986_abnormal_taste_sensitivity0.80477703
77MP0001663_abnormal_digestive_system0.74427577
78MP0008874_decreased_physiological_sensi0.73743754
79MP0002928_abnormal_bile_duct0.71166643
80MP0009763_increased_sensitivity_to0.70389539
81MP0000249_abnormal_blood_vessel0.70233768
82MP0005083_abnormal_biliary_tract0.68810885
83MP0000920_abnormal_myelination0.66905792
84MP0009765_abnormal_xenobiotic_induced0.65536401
85MP0005388_respiratory_system_phenotype0.64486831
86MP0002133_abnormal_respiratory_system0.64486831
87MP0001853_heart_inflammation0.63580694
88MP0002166_altered_tumor_susceptibility0.63458021
89MP0002933_joint_inflammation0.61429750
90MP0005075_abnormal_melanosome_morpholog0.60024698
91MP0004858_abnormal_nervous_system0.59581716
92MP0003795_abnormal_bone_structure0.58878667
93MP0004130_abnormal_muscle_cell0.58804181
94MP0002332_abnormal_exercise_endurance0.56952708
95MP0001348_abnormal_lacrimal_gland0.55938262
96MP0004808_abnormal_hematopoietic_stem0.54197873
97MP0005058_abnormal_lysosome_morphology0.53932902
98MP0003091_abnormal_cell_migration0.52489411
99MP0004484_altered_response_of0.52426892
100MP0009115_abnormal_fat_cell0.51528792

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.79003602
2Myositis (HP:0100614)6.02679368
3Recurrent abscess formation (HP:0002722)5.98144051
4Recurrent bacterial skin infections (HP:0005406)5.87641359
5Orchitis (HP:0100796)5.83582164
6Optic neuritis (HP:0100653)5.46638065
7Retrobulbar optic neuritis (HP:0100654)5.46638065
8Abnormality of macrophages (HP:0004311)5.44259935
9Recurrent gram-negative bacterial infections (HP:0005420)5.11451900
10Stomatitis (HP:0010280)4.78399228
11Hypochromic microcytic anemia (HP:0004840)4.74705021
12Elevated erythrocyte sedimentation rate (HP:0003565)4.65239376
13Gastrointestinal infarctions (HP:0005244)4.62185993
14Chronic obstructive pulmonary disease (HP:0006510)4.24879030
15Obstructive lung disease (HP:0006536)4.24879030
16Increased IgE level (HP:0003212)3.97866742
17Recurrent fungal infections (HP:0002841)3.96513936
18Gingivitis (HP:0000230)3.96395050
19Mediastinal lymphadenopathy (HP:0100721)3.95747150
20Keratoconjunctivitis sicca (HP:0001097)3.90145839
21Meningitis (HP:0001287)3.88239892
22Spontaneous hematomas (HP:0007420)3.84269373
23Recurrent skin infections (HP:0001581)3.81165326
24Peritonitis (HP:0002586)3.76575449
25Hypochromic anemia (HP:0001931)3.65767725
26Encephalitis (HP:0002383)3.61014449
27Prolonged bleeding time (HP:0003010)3.59670401
28Keratoconjunctivitis (HP:0001096)3.57219295
29Abnormal delayed hypersensitivity skin test (HP:0002963)3.53270846
30Urticaria (HP:0001025)3.32117299
31Chronic mucocutaneous candidiasis (HP:0002728)3.31860440
32Recurrent cutaneous fungal infections (HP:0011370)3.31860440
33Vasculitis (HP:0002633)3.29125161
34Chest pain (HP:0100749)3.23609180
35Episodic fever (HP:0001954)3.21448725
36Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.20382413
37Cellulitis (HP:0100658)3.17881570
38Gingival bleeding (HP:0000225)3.06492973
39Hemoptysis (HP:0002105)2.98336335
40Amyloidosis (HP:0011034)2.84423960
41Arterial thrombosis (HP:0004420)2.80648419
42Leukocytosis (HP:0001974)2.79219631
43Nasal polyposis (HP:0100582)2.75325663
44Epistaxis (HP:0000421)2.74644220
45Pulmonary infiltrates (HP:0002113)2.72460504
46T lymphocytopenia (HP:0005403)2.70645416
47Microcytic anemia (HP:0001935)2.66729549
48Pulmonary embolism (HP:0002204)2.66195866
49Petechiae (HP:0000967)2.64550580
50Inflammation of the large intestine (HP:0002037)2.61693005
51Anorexia (HP:0002039)2.60210338
52Abnormality of T cell number (HP:0011839)2.58698076
53Increased IgM level (HP:0003496)2.55812367
54Abnormality of the peritoneum (HP:0002585)2.55729837
55Gastrointestinal inflammation (HP:0004386)2.52384248
56Purpura (HP:0000979)2.39702301
57Slow saccadic eye movements (HP:0000514)2.31252046
58Osteomyelitis (HP:0002754)2.29738795
59Abnormality of the nasal mucosa (HP:0000433)2.29235958
60Abnormal platelet volume (HP:0011876)2.27225966
61Abnormality of T cells (HP:0002843)2.25347075
62Sepsis (HP:0100806)2.23783390
63Granulocytopenia (HP:0001913)2.22600087
64Hypergammaglobulinemia (HP:0010702)2.22459752
65Abnormality of the pleura (HP:0002103)2.21175699
66Vertigo (HP:0002321)2.16020479
67Glomerulopathy (HP:0100820)2.14287943
68Recurrent viral infections (HP:0004429)2.13516543
69Recurrent pneumonia (HP:0006532)2.11503602
70Gangrene (HP:0100758)2.09376964
71Abnormality of the endocardium (HP:0004306)2.09360540
72Pustule (HP:0200039)2.08253697
73Segmental peripheral demyelination/remyelination (HP:0003481)2.06174263
74Lymphopenia (HP:0001888)2.03780762
75Acne (HP:0001061)2.02573117
76Panhypogammaglobulinemia (HP:0003139)2.01418671
77Acute hepatic failure (HP:0006554)2.00688219
78Abnormality of the pericardium (HP:0001697)1.99653969
79Severe visual impairment (HP:0001141)1.99422448
80Hepatosplenomegaly (HP:0001433)1.95308148
81Polycythemia (HP:0001901)1.93257493
82Toxemia of pregnancy (HP:0100603)1.89393010
83Abnormality of cells of the lymphoid lineage (HP:0012140)1.89063787
84Postural instability (HP:0002172)1.88416181
85Abnormality of T cell physiology (HP:0011840)1.87695807
86Asymmetric septal hypertrophy (HP:0001670)1.86312708
87Skin ulcer (HP:0200042)1.85930730
88Eosinophilia (HP:0001880)1.85810208
89Chronic otitis media (HP:0000389)1.85358675
90Papilledema (HP:0001085)1.83888735
91Recurrent lower respiratory tract infections (HP:0002783)1.83159801
92Colitis (HP:0002583)1.82461619
93Abnormality of the heme biosynthetic pathway (HP:0010472)1.82229713
94Keratitis (HP:0000491)1.81417677
95Difficulty running (HP:0009046)1.78127116
96Metaphyseal cupping (HP:0003021)1.77588268
97Loss of speech (HP:0002371)1.77378817
98Premature loss of primary teeth (HP:0006323)1.76995358
99Recurrent sinusitis (HP:0011108)1.75199605
100Recurrent bronchitis (HP:0002837)1.72891002

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK45.17855693
2BLK3.27276734
3IRAK43.16654187
4MAP4K13.08544838
5MAP2K32.89331238
6TYK22.68907890
7CSK2.66958892
8ERN12.64698330
9TNK22.48684823
10EPHB12.47354542
11FES2.40912764
12GRK62.23000622
13ZAP701.88752240
14PRPF4B1.87157293
15TAOK11.85179565
16MAP3K111.80226460
17HCK1.76209974
18JAK31.70874763
19MAP3K31.70043222
20KSR21.68046294
21BTK1.63416281
22FGR1.62757553
23TXK1.53853525
24SYK1.50278223
25JAK21.47431742
26MARK21.37668265
27MAP3K11.33013973
28IKBKE1.31422787
29LYN1.25886040
30JAK11.19434719
31YES11.16506282
32STK381.16125823
33PTK2B1.14397101
34PIK3CG1.14040883
35PRKD21.12289159
36PDK11.10615746
37TBK11.07416065
38KIT1.07083545
39CDK191.04554813
40IRAK11.04377269
41PDPK11.01118525
42LCK1.00780104
43CSF1R0.97935767
44SIK20.97273074
45IRAK20.96672462
46PTK60.95452503
47DYRK1B0.91058763
48MAP3K140.87235658
49BMPR20.85791693
50ITK0.84542441
51MAP3K20.83261611
52SMG10.83068733
53TAOK30.81197720
54MATK0.80315926
55MARK30.80166371
56MAP3K70.80025418
57MAP3K60.79653143
58MAP3K130.79450844
59SIK30.78700324
60TEC0.75591006
61MAP2K40.75283108
62TRIB30.74475385
63TAOK20.71688744
64FYN0.70907339
65STK110.66262431
66SGK30.64774262
67TESK20.63262790
68BRD40.62551804
69STK100.61884907
70WNK10.60018964
71DAPK20.58692001
72EPHA30.58591949
73RPS6KL10.58201615
74RPS6KC10.58201615
75SGK20.57720937
76MAPK120.56306498
77MAPK70.56089169
78RET0.55407687
79PRKG20.55086941
80FGFR30.54241156
81CDC42BPA0.50984670
82RPS6KA60.49589741
83IKBKB0.49237089
84TGFBR20.49131362
85PLK40.47413236
86RAF10.46683202
87LRRK20.46137371
88PRKCZ0.45825589
89FGFR40.45156200
90MAP3K50.44764000
91PRKCQ0.44721601
92HIPK20.44009882
93NLK0.43583339
94SIK10.41402390
95SGK4940.40446145
96SGK2230.40446145
97CAMK40.37880102
98GRK70.36806340
99CAMK10.35948238
100RPS6KA20.35051191

Predicted pathways (KEGG)

RankGene SetZ-score
1Osteoclast differentiation_Homo sapiens_hsa043803.04951103
2Leishmaniasis_Homo sapiens_hsa051402.87721506
3Staphylococcus aureus infection_Homo sapiens_hsa051502.71651105
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.26600824
5Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.25848478
6B cell receptor signaling pathway_Homo sapiens_hsa046622.13518119
7Tuberculosis_Homo sapiens_hsa051522.09670912
8Malaria_Homo sapiens_hsa051442.07044322
9Graft-versus-host disease_Homo sapiens_hsa053321.98769091
10Allograft rejection_Homo sapiens_hsa053301.92551928
11Toll-like receptor signaling pathway_Homo sapiens_hsa046201.89657711
12Autoimmune thyroid disease_Homo sapiens_hsa053201.80231633
13Chemokine signaling pathway_Homo sapiens_hsa040621.78720469
14NOD-like receptor signaling pathway_Homo sapiens_hsa046211.74307457
15Measles_Homo sapiens_hsa051621.70749228
16Primary immunodeficiency_Homo sapiens_hsa053401.68105962
17Acute myeloid leukemia_Homo sapiens_hsa052211.66324674
18Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.64130593
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.60704241
20Hematopoietic cell lineage_Homo sapiens_hsa046401.53030922
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.45681620
22T cell receptor signaling pathway_Homo sapiens_hsa046601.44524263
23African trypanosomiasis_Homo sapiens_hsa051431.43994554
24Type I diabetes mellitus_Homo sapiens_hsa049401.43211826
25Influenza A_Homo sapiens_hsa051641.43096479
26Phagosome_Homo sapiens_hsa041451.41275346
27Antigen processing and presentation_Homo sapiens_hsa046121.40936320
28Toxoplasmosis_Homo sapiens_hsa051451.39636974
29Legionellosis_Homo sapiens_hsa051341.38529465
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.33954726
31Jak-STAT signaling pathway_Homo sapiens_hsa046301.33704704
32Leukocyte transendothelial migration_Homo sapiens_hsa046701.31788691
33Viral myocarditis_Homo sapiens_hsa054161.27705716
34NF-kappa B signaling pathway_Homo sapiens_hsa040641.25828375
35Platelet activation_Homo sapiens_hsa046111.24324215
36Non-small cell lung cancer_Homo sapiens_hsa052231.21397113
37Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.15898950
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.15504927
39Herpes simplex infection_Homo sapiens_hsa051681.14696690
40TNF signaling pathway_Homo sapiens_hsa046681.08679760
41Hepatitis B_Homo sapiens_hsa051611.07468375
42Hepatitis C_Homo sapiens_hsa051601.04222141
43VEGF signaling pathway_Homo sapiens_hsa043701.03699260
44Endocytosis_Homo sapiens_hsa041440.99757277
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.97334248
46Phospholipase D signaling pathway_Homo sapiens_hsa040720.92278721
47Pancreatic cancer_Homo sapiens_hsa052120.91667133
48Pertussis_Homo sapiens_hsa051330.87740754
49Carbohydrate digestion and absorption_Homo sapiens_hsa049730.86043947
50Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85063415
51Chronic myeloid leukemia_Homo sapiens_hsa052200.82858527
52Prolactin signaling pathway_Homo sapiens_hsa049170.82556265
53Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81944073
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81710984
55Salmonella infection_Homo sapiens_hsa051320.81562568
56Renal cell carcinoma_Homo sapiens_hsa052110.81536770
57Notch signaling pathway_Homo sapiens_hsa043300.81252665
58Adipocytokine signaling pathway_Homo sapiens_hsa049200.80880508
59Sphingolipid signaling pathway_Homo sapiens_hsa040710.79735765
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79668119
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.78609786
62Dorso-ventral axis formation_Homo sapiens_hsa043200.78442918
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78196010
64Shigellosis_Homo sapiens_hsa051310.78161314
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77441437
66Apoptosis_Homo sapiens_hsa042100.74128336
67Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70695057
68Choline metabolism in cancer_Homo sapiens_hsa052310.69843011
69Rap1 signaling pathway_Homo sapiens_hsa040150.69337831
70Inositol phosphate metabolism_Homo sapiens_hsa005620.69055856
71Type II diabetes mellitus_Homo sapiens_hsa049300.68241104
72FoxO signaling pathway_Homo sapiens_hsa040680.68019930
73Intestinal immune network for IgA production_Homo sapiens_hsa046720.67832570
74Endometrial cancer_Homo sapiens_hsa052130.67469121
75Amoebiasis_Homo sapiens_hsa051460.66629095
76GnRH signaling pathway_Homo sapiens_hsa049120.66541991
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.64692600
78MAPK signaling pathway_Homo sapiens_hsa040100.61033004
79Rheumatoid arthritis_Homo sapiens_hsa053230.60574657
80Other glycan degradation_Homo sapiens_hsa005110.59736591
81Viral carcinogenesis_Homo sapiens_hsa052030.57890726
82Long-term potentiation_Homo sapiens_hsa047200.57716437
83Estrogen signaling pathway_Homo sapiens_hsa049150.55994235
84Lysosome_Homo sapiens_hsa041420.54885888
85HIF-1 signaling pathway_Homo sapiens_hsa040660.53065638
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52756125
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50849967
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50058923
89Fatty acid biosynthesis_Homo sapiens_hsa000610.49549376
90Colorectal cancer_Homo sapiens_hsa052100.49007207
91mTOR signaling pathway_Homo sapiens_hsa041500.48991771
92Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.47621235
93Morphine addiction_Homo sapiens_hsa050320.47329025
94Gastric acid secretion_Homo sapiens_hsa049710.47081140
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46865145
96Insulin resistance_Homo sapiens_hsa049310.46719520
97Regulation of autophagy_Homo sapiens_hsa041400.45430583
98Asthma_Homo sapiens_hsa053100.45382864
99ErbB signaling pathway_Homo sapiens_hsa040120.44856332
100Epstein-Barr virus infection_Homo sapiens_hsa051690.44767225

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