ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	left/right pattern formation (GO:0060972)	8.71034838
2	regulation of cilium movement (GO:0003352)	7.42773672
3	ventricular system development (GO:0021591)	7.34596939
4	intraciliary transport (GO:0042073)	6.79944139
5	left/right axis specification (GO:0070986)	6.67013187
6	primary alcohol catabolic process (GO:0034310)	6.38215772
7	cilium organization (GO:0044782)	6.28297239
8	microtubule bundle formation (GO:0001578)	6.18505988
9	cilium assembly (GO:0042384)	6.07821021
10	vitamin transmembrane transport (GO:0035461)	5.65619288
11	ethanol metabolic process (GO:0006067)	5.45394077
12	diterpenoid biosynthetic process (GO:0016102)	5.36433748
13	protein localization to cilium (GO:0061512)	4.91363217
14	cellular component assembly involved in morphogenesis (GO:0010927)	4.89582636
15	cilium morphogenesis (GO:0060271)	4.88016021
16	one-carbon compound transport (GO:0019755)	4.87863682
17	centriole assembly (GO:0098534)	4.87142758
18	microtubule-based movement (GO:0007018)	4.75659148
19	pyrimidine-containing compound transmembrane transport (GO:0072531)	4.68493104
20	sperm capacitation (GO:0048240)	4.67106908
21	lung epithelium development (GO:0060428)	4.51740750
22	regulation of microtubule-based movement (GO:0060632)	4.39733503
23	cell projection assembly (GO:0030031)	4.31714716
24	ethanol oxidation (GO:0006069)	4.31011500
25	nucleoside diphosphate phosphorylation (GO:0006165)	4.18449030
26	response to xenobiotic stimulus (GO:0009410)	4.00504956
27	glomerular epithelial cell development (GO:0072310)	3.97878076
28	establishment of apical/basal cell polarity (GO:0035089)	3.89977651
29	retinoic acid metabolic process (GO:0042573)	3.86811500
30	tolerance induction (GO:0002507)	3.81504986
31	negative regulation of humoral immune response (GO:0002921)	3.80225008
32	negative regulation of T cell differentiation in thymus (GO:0033085)	3.75571274
33	regulation of interleukin-5 production (GO:0032674)	3.70477039
34	terpenoid biosynthetic process (GO:0016114)	3.67105513
35	negative regulation of B cell mediated immunity (GO:0002713)	3.66035568
36	negative regulation of immunoglobulin mediated immune response (GO:0002890)	3.66035568
37	retinol metabolic process (GO:0042572)	3.62457524
38	negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)	3.58122272
39	cytoplasmic microtubule organization (GO:0031122)	3.55462369
40	lateral ventricle development (GO:0021670)	3.48791952
41	determination of left/right symmetry (GO:0007368)	3.46308504
42	establishment or maintenance of monopolar cell polarity (GO:0061339)	3.42772032
43	establishment of monopolar cell polarity (GO:0061162)	3.42772032
44	determination of bilateral symmetry (GO:0009855)	3.35044447
45	primary alcohol metabolic process (GO:0034308)	3.31916971
46	regulation of germinal center formation (GO:0002634)	3.31129848
47	specification of symmetry (GO:0009799)	3.28213014
48	glutathione derivative metabolic process (GO:1901685)	3.17299677
49	glutathione derivative biosynthetic process (GO:1901687)	3.17299677
50	regulation of interleukin-13 production (GO:0032656)	3.16245817
51	nonmotile primary cilium assembly (GO:0035058)	3.14522090
52	smoothened signaling pathway (GO:0007224)	3.13390040
53	aldehyde catabolic process (GO:0046185)	3.13131530
54	exogenous drug catabolic process (GO:0042738)	3.10567632
55	CDP-diacylglycerol biosynthetic process (GO:0016024)	3.10259293
56	sperm motility (GO:0030317)	3.06563818
57	retinal rod cell development (GO:0046548)	3.02623705
58	positive regulation of tolerance induction (GO:0002645)	3.02144433
59	carnitine metabolic process (GO:0009437)	3.00519126
60	axonemal dynein complex assembly (GO:0070286)	20.6746212
61	establishment of tissue polarity (GO:0007164)	2.98210672
62	establishment of planar polarity (GO:0001736)	2.98210672
63	positive regulation of smoothened signaling pathway (GO:0045880)	2.94729598
64	O-glycan processing (GO:0016266)	2.93414331
65	negative regulation of inclusion body assembly (GO:0090084)	2.92954706
66	centriole replication (GO:0007099)	2.89401161
67	regulation of autophagic vacuole assembly (GO:2000785)	2.75979791
68	microtubule-based process (GO:0007017)	2.74164035
69	CDP-diacylglycerol metabolic process (GO:0046341)	2.67922294
70	organelle assembly (GO:0070925)	2.61456478
71	microtubule polymerization or depolymerization (GO:0031109)	2.60224529
72	microtubule depolymerization (GO:0007019)	2.60014169
73	apical protein localization (GO:0045176)	2.57467734
74	hydrogen peroxide biosynthetic process (GO:0050665)	2.56230132
75	photoreceptor cell maintenance (GO:0045494)	2.53279247
76	multicellular organismal water homeostasis (GO:0050891)	2.49879358
77	oligosaccharide biosynthetic process (GO:0009312)	2.45393335
78	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	2.44636565
79	intra-S DNA damage checkpoint (GO:0031573)	2.44376036
80	iron ion import (GO:0097286)	2.43926431
81	regulation of vacuole organization (GO:0044088)	2.43563864
82	regulation of microtubule depolymerization (GO:0031114)	2.43556850
83	phosphatidylcholine biosynthetic process (GO:0006656)	2.43370953
84	excretion (GO:0007588)	2.42997632
85	heart looping (GO:0001947)	2.41591097
86	photoreceptor cell differentiation (GO:0046530)	2.41426480
87	eye photoreceptor cell differentiation (GO:0001754)	2.41426480
88	drug catabolic process (GO:0042737)	2.38225519
89	progesterone metabolic process (GO:0042448)	2.33175534
90	nucleotide phosphorylation (GO:0046939)	2.33165980
91	phenol-containing compound catabolic process (GO:0019336)	2.32014317
92	regulation of collateral sprouting (GO:0048670)	2.30625821
93	regulation of smoothened signaling pathway (GO:0008589)	2.28377215
94	water homeostasis (GO:0030104)	2.26305802
95	cilium or flagellum-dependent cell motility (GO:0001539)	17.1069455
96	cilium movement (GO:0003341)	16.0234735
97	epithelial cilium movement (GO:0003351)	14.3557182
98	motile cilium assembly (GO:0044458)	14.1595523
99	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	14.1289580
100	axoneme assembly (GO:0035082)	10.4097250

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.64082677
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.84911824
3	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	2.80865413
4	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.76858806
5	DROSHA_22980978_ChIP-Seq_HELA_Human	2.49060401
6	* PIAS1_25552417_ChIP-Seq_VCAP_Human	2.34397020
7	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.30424425
8	TRIM28_21343339_ChIP-Seq_HEK293_Human	2.24878364
9	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.22155160
10	AHR_22903824_ChIP-Seq_MCF-7_Human	1.96988084
11	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.93979772
12	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.89130367
13	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.85697668
14	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.84022025
15	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.81603676
16	* FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.81058248
17	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.80597372
18	SMAD4_21799915_ChIP-Seq_A2780_Human	1.62606724
19	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.59302536
20	VDR_22108803_ChIP-Seq_LS180_Human	1.58356691
21	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.56972513
22	* TP63_23658742_ChIP-Seq_EP156T_Human	1.56619942
23	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.56239640
24	TP53_18474530_ChIP-ChIP_U2OS_Human	1.56172871
25	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.54324580
26	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.52521545
27	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.50927365
28	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.41481008
29	SOX2_20726797_ChIP-Seq_SW620_Human	1.40459318
30	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.40006577
31	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.39724130
32	FOXA1_25552417_ChIP-Seq_VCAP_Human	1.37797570
33	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.36068723
34	* POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.35348539
35	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.34046064
36	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.33340595
37	* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.32692283
38	ETV1_20927104_ChIP-Seq_GIST48_Human	1.25694710
39	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.25556628
40	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.25168204
41	* STAT3_23295773_ChIP-Seq_U87_Human	1.24910351
42	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.24038203
43	* STAT1_20625510_ChIP-Seq_HELA_Human	1.19606872
44	* PHF8_20622853_ChIP-Seq_HELA_Human	1.19522755
45	* BCAT_22108803_ChIP-Seq_LS180_Human	1.19378930
46	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.18176467
47	* SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.18033880
48	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.18028711
49	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.17087558
50	* SMRT_27268052_Chip-Seq_Bcells_Human	1.16636725
51	* TCF4_22108803_ChIP-Seq_LS180_Human	1.16410258
52	* HNFA_21074721_ChIP-Seq_CACO-2_Human	1.16105541
53	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.15810602
54	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.15030791
55	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.12615055
56	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.10776834
57	* CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.10533396
58	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.10394711
59	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.10280471
60	GBX2_23144817_ChIP-Seq_PC3_Human	1.07773452
61	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.07627235
62	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.07056516
63	RAD21_21589869_ChIP-Seq_MESCs_Mouse	1.07017011
64	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.06660601
65	* TBL1_22424771_ChIP-Seq_293T_Human	1.05390922
66	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.05350628
67	RBPJ_21746931_ChIP-Seq_IB4_Human	1.04530531
68	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.04333745
69	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.04044723
70	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.04044723
71	* CDX2_22108803_ChIP-Seq_LS180_Human	1.03083766
72	KLF5_25053715_ChIP-Seq_YYC3_Human	1.02531422
73	ER_23166858_ChIP-Seq_MCF-7_Human	1.01748048
74	GATA4_25053715_ChIP-Seq_YYC3_Human	1.01666581
75	AR_20517297_ChIP-Seq_VCAP_Human	1.01379871
76	P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.00139377
77	* NFYA_21822215_ChIP-Seq_K562_Human	0.99961880
78	AR_25329375_ChIP-Seq_VCAP_Human	0.99725368
79	FOXA2_19822575_ChIP-Seq_HepG2_Human	0.99549899
80	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.99404051
81	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.99256775
82	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.99154697
83	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	0.99100910
84	* TCF4_23295773_ChIP-Seq_U87_Human	0.98562211
85	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.98507677
86	RUNX2_22187159_ChIP-Seq_PCA_Human	0.98284034
87	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.98148068
88	* NFYB_21822215_ChIP-Seq_K562_Human	0.97917301
89	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.97168550
90	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.97168550
91	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.96344301
92	AR_21572438_ChIP-Seq_LNCaP_Human	0.96111629
93	P300_19829295_ChIP-Seq_ESCs_Human	0.94406751
94	GATA3_24758297_ChIP-Seq_MCF-7_Human	0.94019290
95	FUS_26573619_Chip-Seq_HEK293_Human	0.93321700
96	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	0.92873093
97	CBP_20019798_ChIP-Seq_JUKART_Human	0.92435353
98	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.92435353
99	TAF15_26573619_Chip-Seq_HEK293_Human	0.92325293
100	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.91906543

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002653_abnormal_ependyma_morphology	5.90004067
2	MP0008875_abnormal_xenobiotic_pharmacok	5.75023948
3	MP0001984_abnormal_olfaction	4.40798116
4	MP0002132_abnormal_respiratory_system	3.97095068
5	MP0004043_abnormal_pH_regulation	3.94075979
6	MP0000383_abnormal_hair_follicle	3.69347778
7	MP0004133_heterotaxia	3.55863830
8	MP0009780_abnormal_chondrocyte_physiolo	3.39255187
9	MP0005623_abnormal_meninges_morphology	3.36929493
10	MP0010678_abnormal_skin_adnexa	3.25658307
11	MP0008789_abnormal_olfactory_epithelium	3.10206419
12	MP0000566_synostosis	3.04736801
13	MP0003283_abnormal_digestive_organ	2.77864761
14	MP0002277_abnormal_respiratory_mucosa	2.74267147
15	MP0004019_abnormal_vitamin_homeostasis	2.32714131
16	MP0002909_abnormal_adrenal_gland	2.11652258
17	MP0005394_taste/olfaction_phenotype	2.07355320
18	MP0005499_abnormal_olfactory_system	2.07355320
19	MP0002282_abnormal_trachea_morphology	2.03377075
20	MP0002638_abnormal_pupillary_reflex	1.88720174
21	MP0003656_abnormal_erythrocyte_physiolo	1.80632636
22	MP0005377_hearing/vestibular/ear_phenot	1.69576498
23	MP0003878_abnormal_ear_physiology	1.69576498
24	MP0002168_other_aberrant_phenotype	1.68660279
25	MP0010234_abnormal_vibrissa_follicle	1.64995386
26	MP0001765_abnormal_ion_homeostasis	1.64498004
27	MP0005248_abnormal_Harderian_gland	1.44378781
28	MP0005220_abnormal_exocrine_pancreas	1.43872810
29	MP0002734_abnormal_mechanical_nocicepti	1.43118119
30	MP0009046_muscle_twitch	1.42389889
31	MP0005083_abnormal_biliary_tract	1.40344830
32	MP0002160_abnormal_reproductive_system	1.40325642
33	MP0005253_abnormal_eye_physiology	1.39210108
34	MP0005365_abnormal_bile_salt	1.32732961
35	MP0003136_yellow_coat_color	1.29279925
36	MP0002876_abnormal_thyroid_physiology	1.28842033
37	MP0005636_abnormal_mineral_homeostasis	1.17551194
38	MP0001485_abnormal_pinna_reflex	1.15307488
39	MP0002233_abnormal_nose_morphology	1.15122380
40	MP0003011_delayed_dark_adaptation	1.13038471
41	MP0010030_abnormal_orbit_morphology	1.05849376
42	MP0001346_abnormal_lacrimal_gland	1.04320340
43	MP0005408_hypopigmentation	1.02239236
44	MP0001944_abnormal_pancreas_morphology	1.01758878
45	MP0005395_other_phenotype	0.94667767
46	MP0005551_abnormal_eye_electrophysiolog	0.92104844
47	MP0005503_abnormal_tendon_morphology	0.90166449
48	MP0000026_abnormal_inner_ear	0.89994920
49	MP0001270_distended_abdomen	0.84923514
50	MP0001502_abnormal_circadian_rhythm	0.84670825
51	MP0000013_abnormal_adipose_tissue	0.83744831
52	MP0005165_increased_susceptibility_to	0.83585942
53	MP0001293_anophthalmia	0.83419304
54	MP0005085_abnormal_gallbladder_physiolo	0.82951882
55	MP0002098_abnormal_vibrissa_morphology	0.82430307
56	MP0005391_vision/eye_phenotype	0.80425675
57	MP0003937_abnormal_limbs/digits/tail_de	0.78385602
58	MP0003938_abnormal_ear_development	0.77107019
59	MP0009643_abnormal_urine_homeostasis	0.76620830
60	MP0003806_abnormal_nucleotide_metabolis	0.75011278
61	MP0006036_abnormal_mitochondrial_physio	0.74839112
62	MP0005171_absent_coat_pigmentation	0.74537909
63	MP0005164_abnormal_response_to	0.74253596
64	MP0001486_abnormal_startle_reflex	0.73305337
65	MP0000678_abnormal_parathyroid_gland	0.72832373
66	MP0004883_abnormal_blood_vessel	0.72059911
67	MP0002928_abnormal_bile_duct	0.71966795
68	MP0002249_abnormal_larynx_morphology	0.71847777
69	MP0001324_abnormal_eye_pigmentation	0.71291581
70	MP0005195_abnormal_posterior_eye	0.71163491
71	MP0001929_abnormal_gametogenesis	0.69772860
72	MP0001664_abnormal_digestion	0.68260752
73	MP0002136_abnormal_kidney_physiology	0.67779370
74	MP0000427_abnormal_hair_cycle	0.67600051
75	MP0004885_abnormal_endolymph	0.63967777
76	MP0003698_abnormal_male_reproductive	0.62448899
77	MP0005389_reproductive_system_phenotype	0.62337160
78	MP0001963_abnormal_hearing_physiology	0.62315001
79	MP0001529_abnormal_vocalization	0.61405836
80	MP0008995_early_reproductive_senescence	0.61108004
81	MP0002896_abnormal_bone_mineralization	0.60103504
82	MP0002229_neurodegeneration	0.59146714
83	MP0000681_abnormal_thyroid_gland	0.58271822
84	MP0009765_abnormal_xenobiotic_induced	0.58174043
85	MP0001970_abnormal_pain_threshold	0.57337768
86	MP0003633_abnormal_nervous_system	0.56787225
87	MP0002735_abnormal_chemical_nociception	0.56235557
88	MP0000465_gastrointestinal_hemorrhage	0.56077239
89	MP0010155_abnormal_intestine_physiology	0.55942881
90	MP0006072_abnormal_retinal_apoptosis	0.55209426
91	MP0004270_analgesia	0.54936029
92	MP0009745_abnormal_behavioral_response	0.53591645
93	MP0009703_decreased_birth_body	0.52480425
94	MP0010386_abnormal_urinary_bladder	0.52419218
95	MP0002139_abnormal_hepatobiliary_system	0.52325339
96	MP0000613_abnormal_salivary_gland	0.52145661
97	MP0005646_abnormal_pituitary_gland	0.49595840
98	MP0002116_abnormal_craniofacial_bone	0.49375251
99	MP0003941_abnormal_skin_development	0.48725450
100	MP0002295_abnormal_pulmonary_circulatio	0.47585882

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Rhinitis (HP:0012384)	9.97008600
2	Chronic bronchitis (HP:0004469)	7.85885033
3	Bronchiectasis (HP:0002110)	7.14386646
4	Nasal polyposis (HP:0100582)	6.45904961
5	Abnormality of the nasal mucosa (HP:0000433)	5.34252872
6	Bronchitis (HP:0012387)	4.18605245
7	Recurrent sinusitis (HP:0011108)	4.07693078
8	Chronic sinusitis (HP:0011109)	4.05376241
9	Infertility (HP:0000789)	4.03938453
10	Occipital encephalocele (HP:0002085)	3.90721024
11	Male infertility (HP:0003251)	3.73798942
12	True hermaphroditism (HP:0010459)	3.72971704
13	Pancreatic fibrosis (HP:0100732)	3.71421973
14	Recurrent otitis media (HP:0000403)	3.55523955
15	Molar tooth sign on MRI (HP:0002419)	3.42808301
16	Abnormality of midbrain morphology (HP:0002418)	3.42808301
17	Nephronophthisis (HP:0000090)	3.06774748
18	Pancreatic cysts (HP:0001737)	3.04633329
19	Cystic liver disease (HP:0006706)	2.99036719
20	Hyperactive renin-angiotensin system (HP:0000841)	2.82149819
21	Chronic otitis media (HP:0000389)	2.80962423
22	Chronic hepatic failure (HP:0100626)	2.73821686
23	Medial flaring of the eyebrow (HP:0010747)	2.72484218
24	Atelectasis (HP:0100750)	2.69947327
25	Tubulointerstitial nephritis (HP:0001970)	2.60529914
26	Postaxial foot polydactyly (HP:0001830)	2.58089195
27	Abnormality of the renal medulla (HP:0100957)	2.39350659
28	Congenital primary aphakia (HP:0007707)	2.30978773
29	Gait imbalance (HP:0002141)	2.28255036
30	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.18256762
31	Congenital hepatic fibrosis (HP:0002612)	2.16054064
32	Tubular atrophy (HP:0000092)	2.01686533
33	Nephrogenic diabetes insipidus (HP:0009806)	2.01562214
34	Oculomotor apraxia (HP:0000657)	2.00307302
35	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	12.2567839
36	Abnormal respiratory motile cilium physiology (HP:0012261)	10.9670011
37	Abnormal respiratory epithelium morphology (HP:0012253)	10.8253148
38	Abnormal respiratory motile cilium morphology (HP:0005938)	10.8253148
39	Abnormal ciliary motility (HP:0012262)	10.7757517
40	Dynein arm defect of respiratory motile cilia (HP:0012255)	10.5649755
41	Absent/shortened dynein arms (HP:0200106)	10.5649755
42	Male pseudohermaphroditism (HP:0000037)	1.98040975
43	Anencephaly (HP:0002323)	1.96969136
44	Decreased circulating renin level (HP:0003351)	1.90696876
45	Furrowed tongue (HP:0000221)	1.86708619
46	Postaxial hand polydactyly (HP:0001162)	1.86332011
47	Bell-shaped thorax (HP:0001591)	1.86115762
48	Absent frontal sinuses (HP:0002688)	1.73927121
49	Sclerocornea (HP:0000647)	1.71902543
50	Recurrent bronchitis (HP:0002837)	1.66100391
51	Tubulointerstitial abnormality (HP:0001969)	1.63984920
52	Renal salt wasting (HP:0000127)	1.63642898
53	Nephropathy (HP:0000112)	1.63621192
54	Poor coordination (HP:0002370)	1.61357265
55	Genital tract atresia (HP:0001827)	1.60109681
56	Vaginal atresia (HP:0000148)	1.59715698
57	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.57670902
58	Asplenia (HP:0001746)	1.53788913
59	Hyperkalemia (HP:0002153)	1.51272231
60	Short nail (HP:0001799)	1.46587854
61	Hyperaldosteronism (HP:0000859)	1.42429556
62	Preaxial hand polydactyly (HP:0001177)	1.41349239
63	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	1.40407404
64	Median cleft lip (HP:0000161)	1.37750830
65	Stage 5 chronic kidney disease (HP:0003774)	1.35111643
66	Abnormality of renin-angiotensin system (HP:0000847)	1.33982179
67	Abnormality of dentin (HP:0010299)	1.32605979
68	Abnormal drinking behavior (HP:0030082)	1.31810200
69	Polydipsia (HP:0001959)	1.31810200
70	Abnormality of the dental root (HP:0006486)	1.27704418
71	Taurodontia (HP:0000679)	1.27704418
72	Abnormality of permanent molar morphology (HP:0011071)	1.27704418
73	Supernumerary spleens (HP:0009799)	1.27084302
74	Tubulointerstitial fibrosis (HP:0005576)	1.26379600
75	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.25868745
76	Cone-rod dystrophy (HP:0000548)	1.21259458
77	Hypokalemic alkalosis (HP:0001949)	1.20719012
78	Abnormality of molar (HP:0011077)	1.18083069
79	Abnormality of molar morphology (HP:0011070)	1.18083069
80	Abnormality of chloride homeostasis (HP:0011422)	1.17663630
81	Glucose intolerance (HP:0000833)	1.17218762
82	Aplasia/Hypoplasia of the lens (HP:0008063)	1.16976190
83	Abnormality of the renal cortex (HP:0011035)	1.16231752
84	Prominent nasal bridge (HP:0000426)	1.16200793
85	Short thorax (HP:0010306)	1.14497515
86	Abnormality of the dental pulp (HP:0006479)	1.14249379
87	Large for gestational age (HP:0001520)	1.11124802
88	Bifid scrotum (HP:0000048)	1.10066385
89	Aplasia/Hypoplasia involving the sinuses (HP:0009120)	1.09849020
90	Abnormal rod and cone electroretinograms (HP:0008323)	1.09583413
91	Retinitis pigmentosa (HP:0000510)	1.09378077
92	Abnormality of the frontal sinuses (HP:0002687)	1.09096721
93	Abnormality of abdominal situs (HP:0011620)	1.09027435
94	Abdominal situs inversus (HP:0003363)	1.09027435
95	Abnormal biliary tract physiology (HP:0012439)	1.08574045
96	Bile duct proliferation (HP:0001408)	1.08574045
97	Narrow forehead (HP:0000341)	1.08223982
98	Hyponatremia (HP:0002902)	1.07636104
99	Broad foot (HP:0001769)	1.06728569
100	Decreased central vision (HP:0007663)	1.06105190

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MST4	5.89160799
2	EPHA2	3.88349186
3	PTK2B	2.62163712
4	MAP3K2	2.50963023
5	MAPKAPK3	2.39110299
6	TAF1	2.03998668
7	MAPK15	10.6497702
8	STK24	1.82419903
9	ERBB3	1.82033602
10	TRPM7	1.79412119
11	NME1	1.58848865
12	SMG1	1.49926078
13	BCR	1.44976286
14	MAP3K4	1.38741570
15	MAP3K3	1.31764112
16	IRAK1	1.28404168
17	EEF2K	1.23840691
18	PNCK	1.19023054
19	TTK	1.16448465
20	FRK	1.10847079
21	CSK	0.97823452
22	MAP3K12	0.96530826
23	NEK6	0.94255378
24	EPHB1	0.93893859
25	ACVR1B	0.93545268
26	BMPR2	0.89784300
27	HIPK2	0.89713124
28	STK10	0.88736230
29	STK38	0.87471190
30	BMPR1B	0.85046608
31	LRRK2	0.80964594
32	PRKCI	0.78172878
33	EPHA3	0.78042794
34	TESK1	0.75232275
35	STK38L	0.75004031
36	NEK9	0.73959587
37	MAP3K7	0.72000833
38	CAMK2G	0.71233640
39	CASK	0.69888541
40	ERBB2	0.69429717
41	SGK2	0.67368234
42	NTRK3	0.66192713
43	PASK	0.63975092
44	STK39	0.61848376
45	MUSK	0.60174704
46	SGK494	0.54260786
47	SGK223	0.54260786
48	MARK2	0.53305651
49	ROCK2	0.53236431
50	FER	0.53037239
51	SGK1	0.51081701
52	TLK1	0.49507207
53	LMTK2	0.48842906
54	NLK	0.47383444
55	MST1R	0.46026317
56	SGK3	0.45469628
57	STK16	0.45421590
58	PRKAA2	0.43394068
59	TAOK1	0.42978095
60	PRKCE	0.42668263
61	TBK1	0.42638459
62	RPS6KB2	0.42438238
63	ROCK1	0.41422608
64	PBK	0.41043163
65	MAP2K7	0.40372530
66	CSNK1G2	0.40127613
67	PAK3	0.39933089
68	CCNB1	0.38418341
69	DYRK1A	0.37696458
70	AURKA	0.37278441
71	GRK1	0.36967032
72	DYRK3	0.36931123
73	MAPKAPK5	0.35416232
74	CSNK1G1	0.35203726
75	PRKACA	0.34834743
76	MAPK13	0.34607265
77	CAMKK1	0.34182646
78	PTK6	0.33501404
79	CAMK2A	0.32604684
80	PINK1	0.32424656
81	INSRR	0.32101421
82	MYLK	0.32073179
83	FGFR3	0.31908070
84	ADRBK1	0.31517676
85	PRKCQ	0.30558662
86	ERBB4	0.29758413
87	LATS1	0.27254035
88	ABL1	0.26629200
89	PRKCA	0.26299476
90	PRKCD	0.25393115
91	KSR2	0.25040722
92	CAMK2D	0.24296014
93	MAPK11	0.24083146
94	OXSR1	0.23506902
95	ADRBK2	0.23184117
96	PHKG2	0.21639734
97	PHKG1	0.21639734
98	PRKG1	0.20375128
99	MAP2K4	0.19580499
100	PLK2	0.18947424

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	4.95194020
2	Phenylalanine metabolism_Homo sapiens_hsa00360	4.12151807
3	Histidine metabolism_Homo sapiens_hsa00340	4.05812840
4	Chemical carcinogenesis_Homo sapiens_hsa05204	4.02771928
5	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	3.91546694
6	Tyrosine metabolism_Homo sapiens_hsa00350	3.35633967
7	beta-Alanine metabolism_Homo sapiens_hsa00410	3.09151563
8	Huntingtons disease_Homo sapiens_hsa05016	2.65102725
9	Glutathione metabolism_Homo sapiens_hsa00480	2.43438720
10	Retinol metabolism_Homo sapiens_hsa00830	2.24362837
11	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.91989886
12	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.85307697
13	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.77319292
14	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.74959692
15	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.64580170
16	Caffeine metabolism_Homo sapiens_hsa00232	1.62817763
17	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.59831587
18	ABC transporters_Homo sapiens_hsa02010	1.57745434
19	Sphingolipid metabolism_Homo sapiens_hsa00600	1.57740315
20	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.53750313
21	Peroxisome_Homo sapiens_hsa04146	1.49763734
22	Collecting duct acid secretion_Homo sapiens_hsa04966	1.49546169
23	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.47275405
24	Linoleic acid metabolism_Homo sapiens_hsa00591	1.42988678
25	Circadian rhythm_Homo sapiens_hsa04710	1.41858868
26	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.37225756
27	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.33757532
28	Fatty acid degradation_Homo sapiens_hsa00071	1.21613912
29	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.19119758
30	Tight junction_Homo sapiens_hsa04530	1.14122372
31	Salivary secretion_Homo sapiens_hsa04970	1.09966199
32	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.07625747
33	Butanoate metabolism_Homo sapiens_hsa00650	1.00670878
34	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.93137692
35	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.91586399
36	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.91006605
37	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.89542535
38	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.85919656
39	Insulin secretion_Homo sapiens_hsa04911	0.84121235
40	Taste transduction_Homo sapiens_hsa04742	0.81637781
41	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.79831291
42	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.77548463
43	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.77163737
44	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.72900275
45	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.70479597
46	Phototransduction_Homo sapiens_hsa04744	0.69514587
47	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.69378150
48	Arginine and proline metabolism_Homo sapiens_hsa00330	0.65994126
49	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.61221752
50	Vibrio cholerae infection_Homo sapiens_hsa05110	0.56330881
51	Cocaine addiction_Homo sapiens_hsa05030	0.54295439
52	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.52921588
53	Metabolic pathways_Homo sapiens_hsa01100	0.51246412
54	Nicotine addiction_Homo sapiens_hsa05033	0.50942424
55	Amphetamine addiction_Homo sapiens_hsa05031	0.50282429
56	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.49429465
57	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.49051483
58	Serotonergic synapse_Homo sapiens_hsa04726	0.48171467
59	Propanoate metabolism_Homo sapiens_hsa00640	0.48109812
60	Glycerolipid metabolism_Homo sapiens_hsa00561	0.47950974
61	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.47792097
62	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.45218185
63	Adherens junction_Homo sapiens_hsa04520	0.45197762
64	Notch signaling pathway_Homo sapiens_hsa04330	0.44693196
65	Mineral absorption_Homo sapiens_hsa04978	0.44507341
66	Protein export_Homo sapiens_hsa03060	0.44048093
67	Olfactory transduction_Homo sapiens_hsa04740	0.42500157
68	Tryptophan metabolism_Homo sapiens_hsa00380	0.41818270
69	Basal cell carcinoma_Homo sapiens_hsa05217	0.41692386
70	Nitrogen metabolism_Homo sapiens_hsa00910	0.41572667
71	Pancreatic secretion_Homo sapiens_hsa04972	0.41371498
72	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.40809831
73	cAMP signaling pathway_Homo sapiens_hsa04024	0.40070741
74	Choline metabolism in cancer_Homo sapiens_hsa05231	0.39737521
75	Complement and coagulation cascades_Homo sapiens_hsa04610	0.38582374
76	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.36906283
77	PPAR signaling pathway_Homo sapiens_hsa03320	0.36755251
78	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.34441807
79	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.33600325
80	Regulation of autophagy_Homo sapiens_hsa04140	0.31209642
81	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.28923442
82	Type II diabetes mellitus_Homo sapiens_hsa04930	0.28135758
83	Ether lipid metabolism_Homo sapiens_hsa00565	0.28103307
84	Calcium signaling pathway_Homo sapiens_hsa04020	0.27817350
85	Lysosome_Homo sapiens_hsa04142	0.27616721
86	Bile secretion_Homo sapiens_hsa04976	0.27338223
87	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.25313536
88	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.24269324
89	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.24233376
90	Oxidative phosphorylation_Homo sapiens_hsa00190	0.24056332
91	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.23848067
92	Cardiac muscle contraction_Homo sapiens_hsa04260	0.23435918
93	Hepatitis C_Homo sapiens_hsa05160	0.22982016
94	Circadian entrainment_Homo sapiens_hsa04713	0.21900005
95	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.20201212
96	Pentose phosphate pathway_Homo sapiens_hsa00030	0.17757367
97	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.17017790
98	Pyruvate metabolism_Homo sapiens_hsa00620	0.16308268
99	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.15255478
100	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.14899435

C10ORF107

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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