ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.77086988
2	DNA deamination (GO:0045006)	4.76409598
3	fucose catabolic process (GO:0019317)	4.11804064
4	L-fucose metabolic process (GO:0042354)	4.11804064
5	L-fucose catabolic process (GO:0042355)	4.11804064
6	tryptophan catabolic process (GO:0006569)	3.96161570
7	indole-containing compound catabolic process (GO:0042436)	3.96161570
8	indolalkylamine catabolic process (GO:0046218)	3.96161570
9	negative regulation of telomere maintenance (GO:0032205)	3.80551667
10	kynurenine metabolic process (GO:0070189)	3.67314260
11	indolalkylamine metabolic process (GO:0006586)	3.60081096
12	negative regulation of mast cell activation (GO:0033004)	3.53467274
13	positive regulation of defense response to virus by host (GO:0002230)	3.49047012
14	tryptophan metabolic process (GO:0006568)	3.47003123
15	platelet dense granule organization (GO:0060155)	3.45517609
16	protein complex biogenesis (GO:0070271)	3.45057442
17	detection of light stimulus involved in visual perception (GO:0050908)	3.42918262
18	detection of light stimulus involved in sensory perception (GO:0050962)	3.42918262
19	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.42113458
20	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.42113458
21	NADH dehydrogenase complex assembly (GO:0010257)	3.42113458
22	respiratory chain complex IV assembly (GO:0008535)	3.36835040
23	cellular response to ATP (GO:0071318)	3.34956487
24	response to pheromone (GO:0019236)	3.31937757
25	water-soluble vitamin biosynthetic process (GO:0042364)	3.29509070
26	piRNA metabolic process (GO:0034587)	3.26365432
27	cytochrome complex assembly (GO:0017004)	3.21289459
28	positive regulation of fatty acid transport (GO:2000193)	3.13436891
29	preassembly of GPI anchor in ER membrane (GO:0016254)	3.12497203
30	mitochondrial respiratory chain complex assembly (GO:0033108)	3.10147657
31	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.09949488
32	cellular biogenic amine catabolic process (GO:0042402)	3.09641617
33	amine catabolic process (GO:0009310)	3.09641617
34	positive regulation of prostaglandin secretion (GO:0032308)	3.08670962
35	cellular response to exogenous dsRNA (GO:0071360)	3.05730813
36	protein polyglutamylation (GO:0018095)	3.05448990
37	cellular ketone body metabolic process (GO:0046950)	2.98421486
38	axoneme assembly (GO:0035082)	2.95753682
39	purinergic nucleotide receptor signaling pathway (GO:0035590)	2.90286050
40	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.89155914
41	synaptic transmission, cholinergic (GO:0007271)	2.85175089
42	positive regulation of icosanoid secretion (GO:0032305)	2.80177290
43	ketone body metabolic process (GO:1902224)	2.71856368
44	mannosylation (GO:0097502)	2.71257246
45	sulfation (GO:0051923)	2.67564449
46	DNA methylation involved in gamete generation (GO:0043046)	2.67010520
47	NAD biosynthetic process (GO:0009435)	2.66925600
48	regulation of cilium movement (GO:0003352)	2.60575424
49	adaptation of signaling pathway (GO:0023058)	2.57412187
50	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.56806095
51	protein-cofactor linkage (GO:0018065)	2.56070143
52	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.55916810
53	exogenous drug catabolic process (GO:0042738)	2.54145610
54	GPI anchor metabolic process (GO:0006505)	2.50490223
55	epithelial cilium movement (GO:0003351)	2.50458461
56	ATP synthesis coupled proton transport (GO:0015986)	2.50170626
57	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.50170626
58	protein localization to cilium (GO:0061512)	2.49192819
59	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.48991256
60	regulation of action potential (GO:0098900)	2.48698595
61	indole-containing compound metabolic process (GO:0042430)	2.48570352
62	ubiquinone biosynthetic process (GO:0006744)	2.47695948
63	cytidine metabolic process (GO:0046087)	2.46868428
64	cytidine catabolic process (GO:0006216)	2.46868428
65	cytidine deamination (GO:0009972)	2.46868428
66	aromatic amino acid family catabolic process (GO:0009074)	2.45792006
67	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.45401826
68	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.45401826
69	drug catabolic process (GO:0042737)	2.43672816
70	S-adenosylmethionine metabolic process (GO:0046500)	2.43050096
71	phosphatidylglycerol biosynthetic process (GO:0006655)	2.42954534
72	negative regulation of T cell differentiation in thymus (GO:0033085)	2.42913113
73	multicellular organism reproduction (GO:0032504)	2.40951444
74	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.40739925
75	behavioral response to ethanol (GO:0048149)	2.40073016
76	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.37865855
77	glycerophospholipid catabolic process (GO:0046475)	2.37457738
78	negative regulation of interleukin-1 beta production (GO:0032691)	2.36979011
79	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.36300430
80	neuronal action potential (GO:0019228)	2.35107888
81	gamma-aminobutyric acid transport (GO:0015812)	2.34882805
82	benzene-containing compound metabolic process (GO:0042537)	2.34401739
83	cilium or flagellum-dependent cell motility (GO:0001539)	2.32978329
84	positive regulation of organic acid transport (GO:0032892)	2.31443558
85	regulation of prostaglandin secretion (GO:0032306)	2.31309741
86	reciprocal DNA recombination (GO:0035825)	2.31049330
87	reciprocal meiotic recombination (GO:0007131)	2.31049330
88	basic amino acid transport (GO:0015802)	2.30267678
89	pseudouridine synthesis (GO:0001522)	2.29794943
90	arginine catabolic process (GO:0006527)	2.29473067
91	parturition (GO:0007567)	2.29135611
92	estrogen biosynthetic process (GO:0006703)	2.28039282
93	neurotransmitter metabolic process (GO:0042133)	2.27908301
94	alanine transport (GO:0032328)	2.27747021
95	cornea development in camera-type eye (GO:0061303)	2.26423017
96	transepithelial transport (GO:0070633)	2.25767203
97	negative regulation of interleukin-1 production (GO:0032692)	2.25487486
98	base-excision repair, AP site formation (GO:0006285)	2.25192078
99	nephron tubule morphogenesis (GO:0072078)	2.25041829
100	nephron epithelium morphogenesis (GO:0072088)	2.25041829

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.00964555
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.28994866
3	VDR_22108803_ChIP-Seq_LS180_Human	3.22387409
4	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.11135928
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.31383285
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.20229968
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.07117313
8	GBX2_23144817_ChIP-Seq_PC3_Human	2.04479542
9	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	2.03434351
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.84677152
11	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.75091314
12	TP53_22573176_ChIP-Seq_HFKS_Human	1.73588050
13	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.71905512
14	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.67744756
15	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.65155500
16	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.59999143
17	ERA_21632823_ChIP-Seq_H3396_Human	1.58247674
18	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.57952943
19	TAF2_19829295_ChIP-Seq_ESCs_Human	1.56570232
20	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.54397580
21	* CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.53507175
22	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.51092680
23	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.47461229
24	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.44717275
25	NANOG_20526341_ChIP-Seq_ESCs_Human	1.43995216
26	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.43972949
27	REST_21632747_ChIP-Seq_MESCs_Mouse	1.43797942
28	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.43518290
29	ER_23166858_ChIP-Seq_MCF-7_Human	1.42784084
30	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.41295250
31	IRF1_19129219_ChIP-ChIP_H3396_Human	1.39917354
32	MYC_19829295_ChIP-Seq_ESCs_Human	1.39497649
33	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.38561662
34	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.38111671
35	TAF15_26573619_Chip-Seq_HEK293_Human	1.37300116
36	* EWS_26573619_Chip-Seq_HEK293_Human	1.36989606
37	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.36804102
38	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.32974210
39	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.32053315
40	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.31891464
41	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.31679757
42	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.31148680
43	* FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.30840937
44	* FOXA1_25329375_ChIP-Seq_VCAP_Human	1.30840937
45	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.30482515
46	* AR_20517297_ChIP-Seq_VCAP_Human	1.30414514
47	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.29843343
48	E2F1_20622854_ChIP-Seq_HELA_Human	1.28027980
49	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.28004691
50	BCL6_27268052_Chip-Seq_Bcells_Human	1.27352355
51	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.26648535
52	* NCOR_22424771_ChIP-Seq_293T_Human	1.26370349
53	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.26081503
54	CBP_20019798_ChIP-Seq_JUKART_Human	1.26081503
55	* SOX2_19829295_ChIP-Seq_ESCs_Human	1.25964319
56	* NANOG_19829295_ChIP-Seq_ESCs_Human	1.25964319
57	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.25796236
58	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.24673103
59	* FUS_26573619_Chip-Seq_HEK293_Human	1.23475758
60	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.23120437
61	OCT4_20526341_ChIP-Seq_ESCs_Human	1.23058715
62	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.22885280
63	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.22359241
64	RAC3_21632823_ChIP-Seq_H3396_Human	1.19180759
65	GATA3_26560356_Chip-Seq_TH2_Human	1.18525847
66	* P300_19829295_ChIP-Seq_ESCs_Human	1.17729397
67	* P53_21459846_ChIP-Seq_SAOS-2_Human	1.16257049
68	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.14101146
69	MYC_18940864_ChIP-ChIP_HL60_Human	1.13674076
70	* BCAT_22108803_ChIP-Seq_LS180_Human	1.13640215
71	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.13473878
72	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.13210114
73	HOXB7_26014856_ChIP-Seq_BT474_Human	1.12735449
74	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.11050789
75	P300_27268052_Chip-Seq_Bcells_Human	1.10556851
76	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.10180485
77	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.09046046
78	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.08869071
79	VDR_23849224_ChIP-Seq_CD4+_Human	1.08567547
80	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.06692709
81	* FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.05298550
82	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.04544113
83	STAT1_20625510_ChIP-Seq_HELA_Human	1.04103236
84	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.02143222
85	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.01041349
86	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.00676928
87	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	0.99591318
88	* AR_25329375_ChIP-Seq_VCAP_Human	0.97128017
89	* TCF4_23295773_ChIP-Seq_U87_Human	0.95065418
90	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.94453492
91	* STAT3_23295773_ChIP-Seq_U87_Human	0.94393501
92	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.93935894
93	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.93935894
94	PHF8_20622854_ChIP-Seq_HELA_Human	0.93759709
95	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.93115664
96	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.92937746
97	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.91944327
98	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.91338265
99	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	0.90833282
100	BCOR_27268052_Chip-Seq_Bcells_Human	0.90073419

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	3.05168084
2	MP0001986_abnormal_taste_sensitivity	2.96335664
3	MP0008875_abnormal_xenobiotic_pharmacok	2.83195679
4	MP0001968_abnormal_touch/_nociception	2.57973555
5	MP0003646_muscle_fatigue	2.51509715
6	MP0005551_abnormal_eye_electrophysiolog	2.33171731
7	MP0005174_abnormal_tail_pigmentation	2.22059421
8	MP0008877_abnormal_DNA_methylation	2.12114123
9	MP0002102_abnormal_ear_morphology	2.04803135
10	MP0002876_abnormal_thyroid_physiology	2.03414282
11	MP0003806_abnormal_nucleotide_metabolis	1.98404795
12	MP0002837_dystrophic_cardiac_calcinosis	1.96098486
13	MP0003787_abnormal_imprinting	1.96072423
14	MP0003136_yellow_coat_color	1.92873064
15	MP0004043_abnormal_pH_regulation	1.84557667
16	MP0005646_abnormal_pituitary_gland	1.81544364
17	MP0004142_abnormal_muscle_tone	1.75776802
18	MP0005167_abnormal_blood-brain_barrier	1.72202538
19	MP0002736_abnormal_nociception_after	1.69791908
20	MP0008872_abnormal_physiological_respon	1.69342524
21	MP0005671_abnormal_response_to	1.68554038
22	MP0000372_irregular_coat_pigmentation	1.64379281
23	MP0002138_abnormal_hepatobiliary_system	1.64314494
24	MP0005084_abnormal_gallbladder_morpholo	1.64276393
25	MP0005645_abnormal_hypothalamus_physiol	1.60263699
26	MP0002638_abnormal_pupillary_reflex	1.60214794
27	MP0004147_increased_porphyrin_level	1.54478556
28	MP0000569_abnormal_digit_pigmentation	1.53965582
29	MP0009745_abnormal_behavioral_response	1.53293699
30	MP0006276_abnormal_autonomic_nervous	1.51237485
31	MP0009764_decreased_sensitivity_to	1.50573468
32	MP0001501_abnormal_sleep_pattern	1.50160166
33	MP0005423_abnormal_somatic_nervous	1.50152365
34	MP0002148_abnormal_hypersensitivity_rea	1.48599267
35	MP0009046_muscle_twitch	1.44637659
36	MP0006072_abnormal_retinal_apoptosis	1.42002901
37	MP0002163_abnormal_gland_morphology	1.41382688
38	MP0002272_abnormal_nervous_system	1.39580910
39	MP0003011_delayed_dark_adaptation	1.34630150
40	MP0001970_abnormal_pain_threshold	1.32066192
41	MP0002653_abnormal_ependyma_morphology	1.30758014
42	MP0010386_abnormal_urinary_bladder	1.30495755
43	MP0005253_abnormal_eye_physiology	1.30013107
44	MP0006292_abnormal_olfactory_placode	1.29891200
45	MP0001835_abnormal_antigen_presentation	1.29302518
46	MP0003724_increased_susceptibility_to	1.26651337
47	MP0005410_abnormal_fertilization	1.23330719
48	MP0004885_abnormal_endolymph	1.21488854
49	MP0002735_abnormal_chemical_nociception	1.20191929
50	MP0004742_abnormal_vestibular_system	1.19411176
51	MP0005379_endocrine/exocrine_gland_phen	1.18021341
52	MP0002733_abnormal_thermal_nociception	1.17553205
53	MP0005332_abnormal_amino_acid	1.13025468
54	MP0005075_abnormal_melanosome_morpholog	1.12706300
55	MP0000230_abnormal_systemic_arterial	1.10051201
56	MP0005389_reproductive_system_phenotype	1.09377516
57	MP0001905_abnormal_dopamine_level	1.09088744
58	MP0002095_abnormal_skin_pigmentation	1.06386317
59	MP0001919_abnormal_reproductive_system	1.05756268
60	MP0009785_altered_susceptibility_to	1.04628057
61	MP0001984_abnormal_olfaction	1.04097290
62	MP0001486_abnormal_startle_reflex	1.03510264
63	MP0001485_abnormal_pinna_reflex	1.01736786
64	MP0002572_abnormal_emotion/affect_behav	1.01578264
65	MP0001790_abnormal_immune_system	1.01441394
66	MP0005387_immune_system_phenotype	1.01441394
67	MP0004133_heterotaxia	1.00969927
68	MP0000685_abnormal_immune_system	0.99631141
69	MP0005365_abnormal_bile_salt	0.99588906
70	MP0000427_abnormal_hair_cycle	0.98679974
71	MP0002064_seizures	0.96396027
72	MP0001800_abnormal_humoral_immune	0.95596791
73	MP0006082_CNS_inflammation	0.94180197
74	MP0000015_abnormal_ear_pigmentation	0.94172738
75	MP0003878_abnormal_ear_physiology	0.92561341
76	MP0005377_hearing/vestibular/ear_phenot	0.92561341
77	MP0008775_abnormal_heart_ventricle	0.92524862
78	MP0005195_abnormal_posterior_eye	0.91901475
79	MP0002557_abnormal_social/conspecific_i	0.91688829
80	MP0001764_abnormal_homeostasis	0.91502236
81	MP0001324_abnormal_eye_pigmentation	0.90932431
82	MP0002723_abnormal_immune_serum	0.90453281
83	MP0002160_abnormal_reproductive_system	0.90321855
84	MP0005171_absent_coat_pigmentation	0.88594737
85	MP0001502_abnormal_circadian_rhythm	0.88446700
86	MP0004130_abnormal_muscle_cell	0.88328973
87	MP0002067_abnormal_sensory_capabilities	0.87714015
88	MP0002693_abnormal_pancreas_physiology	0.86507480
89	MP0004145_abnormal_muscle_electrophysio	0.85070746
90	MP0003122_maternal_imprinting	0.84879350
91	MP0002928_abnormal_bile_duct	0.84866392
92	MP0002229_neurodegeneration	0.83658477
93	MP0003121_genomic_imprinting	0.82029614
94	MP0005025_abnormal_response_to	0.81807008
95	MP0004924_abnormal_behavior	0.80173672
96	MP0005386_behavior/neurological_phenoty	0.80173672
97	MP0002277_abnormal_respiratory_mucosa	0.79757701
98	MP0002452_abnormal_antigen_presenting	0.79217153
99	MP0001756_abnormal_urination	0.79042954
100	MP0005085_abnormal_gallbladder_physiolo	0.76651070

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	4.44643880
2	Molar tooth sign on MRI (HP:0002419)	4.00327167
3	Abnormality of midbrain morphology (HP:0002418)	4.00327167
4	Pancreatic cysts (HP:0001737)	3.89676727
5	Type II lissencephaly (HP:0007260)	3.68106144
6	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.56106009
7	Nephronophthisis (HP:0000090)	3.52062685
8	Pancreatic fibrosis (HP:0100732)	3.46987404
9	Attenuation of retinal blood vessels (HP:0007843)	3.39681014
10	Abolished electroretinogram (ERG) (HP:0000550)	3.24726893
11	True hermaphroditism (HP:0010459)	3.18163229
12	Decreased central vision (HP:0007663)	3.05309837
13	Polydipsia (HP:0001959)	2.99481352
14	Abnormal drinking behavior (HP:0030082)	2.99481352
15	Abnormality of the renal medulla (HP:0100957)	2.95444581
16	Mitochondrial inheritance (HP:0001427)	2.82910339
17	Abnormality of the renal cortex (HP:0011035)	2.74400808
18	Abnormal rod and cone electroretinograms (HP:0008323)	2.73959051
19	Increased CSF lactate (HP:0002490)	2.70335589
20	Chronic hepatic failure (HP:0100626)	2.69789174
21	Hepatocellular necrosis (HP:0001404)	2.67995067
22	Tubular atrophy (HP:0000092)	2.66535714
23	Abnormality of alanine metabolism (HP:0010916)	2.60682641
24	Hyperalaninemia (HP:0003348)	2.60682641
25	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.60682641
26	Cerebellar dysplasia (HP:0007033)	2.59300798
27	Acute necrotizing encephalopathy (HP:0006965)	2.58078744
28	Pendular nystagmus (HP:0012043)	2.54814790
29	Hepatic necrosis (HP:0002605)	2.47505014
30	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.41911669
31	Polyuria (HP:0000103)	2.40856401
32	Lipid accumulation in hepatocytes (HP:0006561)	2.38618052
33	Cystic liver disease (HP:0006706)	2.36344621
34	Decreased circulating renin level (HP:0003351)	2.36099177
35	Stomatitis (HP:0010280)	2.33399469
36	Hyperventilation (HP:0002883)	2.33360060
37	Medial flaring of the eyebrow (HP:0010747)	2.31761765
38	Abnormal mitochondria in muscle tissue (HP:0008316)	2.31686261
39	Mesangial abnormality (HP:0001966)	2.29165787
40	Abnormal biliary tract physiology (HP:0012439)	2.26831017
41	Bile duct proliferation (HP:0001408)	2.26831017
42	Retinal dysplasia (HP:0007973)	2.25288047
43	Hypoplasia of the pons (HP:0012110)	2.25113591
44	Abnormality of the pons (HP:0007361)	2.23901446
45	Acute encephalopathy (HP:0006846)	2.23842413
46	Lissencephaly (HP:0001339)	2.23130380
47	Elevated erythrocyte sedimentation rate (HP:0003565)	2.22710896
48	Progressive macrocephaly (HP:0004481)	2.21090449
49	Optic disc pallor (HP:0000543)	2.15036153
50	Bony spicule pigmentary retinopathy (HP:0007737)	2.09145434
51	3-Methylglutaconic aciduria (HP:0003535)	2.07215137
52	Methylmalonic aciduria (HP:0012120)	2.06391665
53	Congenital hepatic fibrosis (HP:0002612)	2.04142731
54	Inability to walk (HP:0002540)	2.02765076
55	Abnormal urine output (HP:0012590)	2.01836160
56	Polyphagia (HP:0002591)	2.01569901
57	Renal Fanconi syndrome (HP:0001994)	2.01566707
58	Rib fusion (HP:0000902)	2.01390221
59	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.00062348
60	Pachygyria (HP:0001302)	1.96762205
61	Increased hepatocellular lipid droplets (HP:0006565)	1.96290018
62	Absent/shortened dynein arms (HP:0200106)	1.96053163
63	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.96053163
64	Sclerocornea (HP:0000647)	1.94355801
65	Increased neuronal autofluorescent lipopigment (HP:0002074)	1.93898020
66	Stomach cancer (HP:0012126)	1.93332357
67	Absent thumb (HP:0009777)	1.91659797
68	Ketosis (HP:0001946)	1.91491071
69	Keratoconus (HP:0000563)	1.91164054
70	Increased corneal curvature (HP:0100692)	1.91164054
71	Clumsiness (HP:0002312)	1.90919161
72	Severe muscular hypotonia (HP:0006829)	1.89997503
73	Increased serum lactate (HP:0002151)	1.89890349
74	Chorioretinal atrophy (HP:0000533)	1.89287191
75	Tachypnea (HP:0002789)	1.87624707
76	Retinal atrophy (HP:0001105)	1.86996371
77	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.83271401
78	Anencephaly (HP:0002323)	1.83037192
79	Methylmalonic acidemia (HP:0002912)	1.82071526
80	Progressive microcephaly (HP:0000253)	1.80173548
81	Macular degeneration (HP:0000608)	1.79266501
82	Type 2 muscle fiber atrophy (HP:0003554)	1.78649974
83	Concave nail (HP:0001598)	1.76316634
84	Abnormality of renal excretion (HP:0011036)	1.75416068
85	Renal cortical cysts (HP:0000803)	1.74690864
86	Agitation (HP:0000713)	1.73765049
87	Asplenia (HP:0001746)	1.73359732
88	Congenital sensorineural hearing impairment (HP:0008527)	1.73139268
89	Male pseudohermaphroditism (HP:0000037)	1.72499570
90	Lactic acidosis (HP:0003128)	1.71487253
91	Genetic anticipation (HP:0003743)	1.69993635
92	Increased muscle lipid content (HP:0009058)	1.69331641
93	Abnormal respiratory epithelium morphology (HP:0012253)	1.68200340
94	Abnormal respiratory motile cilium morphology (HP:0005938)	1.68200340
95	Congenital, generalized hypertrichosis (HP:0004540)	1.67414342
96	Progressive cerebellar ataxia (HP:0002073)	1.66328715
97	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.65834027
98	Optic neuritis (HP:0100653)	1.64521002
99	Retrobulbar optic neuritis (HP:0100654)	1.64521002
100	Ketoacidosis (HP:0001993)	1.64262450

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.08354372
2	ADRBK2	3.77990774
3	TLK1	3.66491899
4	WNK4	3.15028258
5	TAOK3	2.90061906
6	BMPR1B	2.76718921
7	ZAK	2.74086016
8	PINK1	2.64478493
9	MAP4K2	2.62804973
10	GRK1	2.61096163
11	TXK	2.50740720
12	BCKDK	2.31925887
13	ACVR1B	2.21321530
14	NUAK1	1.94002622
15	DAPK2	1.80925210
16	TIE1	1.66256127
17	WNK3	1.61444679
18	MAPK15	1.58739909
19	KIT	1.51411418
20	MAPK13	1.50992614
21	OXSR1	1.49611452
22	MAP2K6	1.36868007
23	ADRBK1	1.32060534
24	INSRR	1.31335085
25	IKBKB	1.30967718
26	MAP4K1	1.25896205
27	MAPKAPK3	1.23126016
28	STK39	1.21086822
29	MAP3K11	1.19635860
30	GRK7	1.18639852
31	STK16	1.13432291
32	MUSK	1.12345085
33	DYRK2	1.11741701
34	CAMKK2	1.01096310
35	TEC	0.98200921
36	TGFBR1	0.97928355
37	SYK	0.94356342
38	SIK2	0.92223551
39	PRKCQ	0.90713767
40	MAP3K4	0.85719295
41	MARK3	0.85305256
42	KDR	0.84766422
43	STK11	0.77919559
44	PRKCG	0.77369125
45	PHKG2	0.75029415
46	PHKG1	0.75029415
47	BLK	0.73973921
48	CSNK1G2	0.73611406
49	GRK6	0.72165558
50	RPS6KA5	0.70765070
51	CASK	0.70324269
52	MAP2K7	0.69981895
53	PIK3CA	0.69409777
54	IKBKE	0.69323590
55	TNK2	0.68104706
56	CSNK1G3	0.67012356
57	ITK	0.63004800
58	PIM2	0.62322223
59	PRKCE	0.62040678
60	MAP2K2	0.62037366
61	MAPKAPK5	0.60224969
62	VRK1	0.60037597
63	FLT3	0.59327216
64	LYN	0.57825792
65	TRIM28	0.57707703
66	CSF1R	0.55508718
67	CAMK1	0.55254783
68	PRKCI	0.54867319
69	CSNK1A1L	0.54716163
70	RPS6KA6	0.54286157
71	MATK	0.51221396
72	PRKACA	0.50751542
73	CSNK1G1	0.50587867
74	PTK2B	0.48890689
75	TBK1	0.47948471
76	PAK3	0.47710148
77	FES	0.46698123
78	PKN1	0.45199148
79	LCK	0.44413338
80	CAMKK1	0.44207777
81	PRKCA	0.44127986
82	ABL2	0.43233827
83	CHUK	0.41831015
84	TESK2	0.41360261
85	NME1	0.40432796
86	CSNK1A1	0.39684113
87	PRKCH	0.39372848
88	VRK2	0.38803299
89	IRAK4	0.38798894
90	PIM1	0.38674089
91	JAK3	0.38119967
92	NTRK2	0.37787137
93	BTK	0.37223228
94	PRKCZ	0.36219047
95	OBSCN	0.36026459
96	PRKAA2	0.35901693
97	CAMK2A	0.34880408
98	ABL1	0.33579776
99	WNK1	0.32747258
100	PRKG1	0.30990768

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	2.75461291
2	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.58645843
3	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.57782083
4	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.57186686
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.51004651
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.48567910
7	Phototransduction_Homo sapiens_hsa04744	2.46998451
8	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.39829386
9	Linoleic acid metabolism_Homo sapiens_hsa00591	2.38313708
10	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.24997224
11	Allograft rejection_Homo sapiens_hsa05330	1.98884895
12	Nitrogen metabolism_Homo sapiens_hsa00910	1.95718793
13	Graft-versus-host disease_Homo sapiens_hsa05332	1.93679806
14	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.86258056
15	Parkinsons disease_Homo sapiens_hsa05012	1.86180818
16	Type I diabetes mellitus_Homo sapiens_hsa04940	1.76748322
17	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.76055075
18	Butanoate metabolism_Homo sapiens_hsa00650	1.72956054
19	Ether lipid metabolism_Homo sapiens_hsa00565	1.67210806
20	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.64308609
21	Tryptophan metabolism_Homo sapiens_hsa00380	1.56653735
22	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.54757796
23	Caffeine metabolism_Homo sapiens_hsa00232	1.49646823
24	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.46615493
25	Rheumatoid arthritis_Homo sapiens_hsa05323	1.43272077
26	Nicotine addiction_Homo sapiens_hsa05033	1.42567236
27	Selenocompound metabolism_Homo sapiens_hsa00450	1.39858391
28	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.37635755
29	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.34932835
30	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.33905857
31	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.27753398
32	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.27340949
33	Peroxisome_Homo sapiens_hsa04146	1.27185350
34	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.26544723
35	Sulfur relay system_Homo sapiens_hsa04122	1.25919886
36	Primary immunodeficiency_Homo sapiens_hsa05340	1.25647036
37	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.24975592
38	Cardiac muscle contraction_Homo sapiens_hsa04260	1.21512233
39	RNA polymerase_Homo sapiens_hsa03020	1.20003601
40	Alzheimers disease_Homo sapiens_hsa05010	1.17377030
41	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.15223634
42	Chemical carcinogenesis_Homo sapiens_hsa05204	1.14960827
43	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.14360699
44	Huntingtons disease_Homo sapiens_hsa05016	1.07657005
45	Collecting duct acid secretion_Homo sapiens_hsa04966	1.07397385
46	Homologous recombination_Homo sapiens_hsa03440	1.06134097
47	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.01764711
48	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.01172761
49	ABC transporters_Homo sapiens_hsa02010	1.00243573
50	Fanconi anemia pathway_Homo sapiens_hsa03460	1.00007673
51	Taste transduction_Homo sapiens_hsa04742	0.99586932
52	Olfactory transduction_Homo sapiens_hsa04740	0.95481770
53	Morphine addiction_Homo sapiens_hsa05032	0.95429528
54	Protein export_Homo sapiens_hsa03060	0.89013426
55	Regulation of autophagy_Homo sapiens_hsa04140	0.88175772
56	Basal transcription factors_Homo sapiens_hsa03022	0.87145581
57	Antigen processing and presentation_Homo sapiens_hsa04612	0.86730548
58	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.85829601
59	Retinol metabolism_Homo sapiens_hsa00830	0.84508897
60	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.83675589
61	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.83659897
62	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.80555349
63	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.78955062
64	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.78253803
65	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.75544058
66	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.71533149
67	Lysosome_Homo sapiens_hsa04142	0.69472928
68	Ribosome_Homo sapiens_hsa03010	0.69249035
69	Propanoate metabolism_Homo sapiens_hsa00640	0.67164859
70	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.62261615
71	GABAergic synapse_Homo sapiens_hsa04727	0.58499881
72	beta-Alanine metabolism_Homo sapiens_hsa00410	0.58121374
73	Serotonergic synapse_Homo sapiens_hsa04726	0.57135572
74	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.56850365
75	Metabolic pathways_Homo sapiens_hsa01100	0.56231075
76	Mineral absorption_Homo sapiens_hsa04978	0.56102575
77	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.55426113
78	Salivary secretion_Homo sapiens_hsa04970	0.54289272
79	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.54087132
80	Fat digestion and absorption_Homo sapiens_hsa04975	0.54082225
81	Sulfur metabolism_Homo sapiens_hsa00920	0.53964731
82	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.53292887
83	Fatty acid degradation_Homo sapiens_hsa00071	0.51910267
84	One carbon pool by folate_Homo sapiens_hsa00670	0.51900512
85	Insulin secretion_Homo sapiens_hsa04911	0.51266786
86	Calcium signaling pathway_Homo sapiens_hsa04020	0.51026248
87	RNA degradation_Homo sapiens_hsa03018	0.50091250
88	Glycerolipid metabolism_Homo sapiens_hsa00561	0.50026950
89	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.49678203
90	Circadian entrainment_Homo sapiens_hsa04713	0.46246763
91	Purine metabolism_Homo sapiens_hsa00230	0.45944988
92	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.45475718
93	Pyrimidine metabolism_Homo sapiens_hsa00240	0.44590904
94	Glutamatergic synapse_Homo sapiens_hsa04724	0.41088518
95	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.40461353
96	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.40347530
97	Leishmaniasis_Homo sapiens_hsa05140	0.39862125
98	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.36036224
99	Tuberculosis_Homo sapiens_hsa05152	0.35762678
100	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.35557463

C10ORF11

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »