ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sphingosine metabolic process (GO:0006670)	9.28961185
2	diol metabolic process (GO:0034311)	8.25630703
3	sphingoid metabolic process (GO:0046519)	7.57680344
4	protein-chromophore linkage (GO:0018298)	6.68323569
5	regulation of odontogenesis of dentin-containing tooth (GO:0042487)	5.50861944
6	DNA methylation involved in gamete generation (GO:0043046)	5.18804094
7	regulation of meiosis I (GO:0060631)	4.97732630
8	lipopolysaccharide biosynthetic process (GO:0009103)	4.83776120
9	glycerophospholipid catabolic process (GO:0046475)	4.69419014
10	paraxial mesoderm development (GO:0048339)	4.67766870
11	nodal signaling pathway (GO:0038092)	4.67007733
12	sulfate transmembrane transport (GO:1902358)	4.43318368
13	regulation of protein glycosylation (GO:0060049)	4.33609161
14	L-phenylalanine catabolic process (GO:0006559)	4.11180988
15	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	4.11180988
16	sulfate transport (GO:0008272)	4.06457502
17	lipopolysaccharide metabolic process (GO:0008653)	4.05364155
18	positive regulation of developmental pigmentation (GO:0048087)	3.99427350
19	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	3.98529044
20	L-phenylalanine metabolic process (GO:0006558)	3.98529044
21	piRNA metabolic process (GO:0034587)	3.95104027
22	regulation of pigment cell differentiation (GO:0050932)	3.89806251
23	negative regulation of glycoprotein biosynthetic process (GO:0010561)	3.84048568
24	heme transport (GO:0015886)	3.76404691
25	adaptation of signaling pathway (GO:0023058)	3.69866549
26	tyrosine metabolic process (GO:0006570)	3.68231473
27	nonmotile primary cilium assembly (GO:0035058)	3.63576377
28	ribonucleoprotein complex disassembly (GO:0032988)	3.63070139
29	regulation of cilium movement (GO:0003352)	3.61646451
30	axoneme assembly (GO:0035082)	3.60575910
31	glyoxylate metabolic process (GO:0046487)	3.46804289
32	brain morphogenesis (GO:0048854)	3.45840351
33	toxin metabolic process (GO:0009404)	3.45609172
34	mesenchyme morphogenesis (GO:0072132)	3.38825113
35	positive regulation of neurotransmitter secretion (GO:0001956)	3.37872152
36	positive regulation of neurotransmitter transport (GO:0051590)	3.33780282
37	water-soluble vitamin biosynthetic process (GO:0042364)	3.31222994
38	regulation of neurotransmitter uptake (GO:0051580)	3.30909690
39	presynaptic membrane assembly (GO:0097105)	3.24809593
40	vitamin transmembrane transport (GO:0035461)	3.24206618
41	regulation of cardioblast proliferation (GO:0003264)	3.21197316
42	regulation of secondary heart field cardioblast proliferation (GO:0003266)	3.21197316
43	aldehyde catabolic process (GO:0046185)	3.17663387
44	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	3.16334922
45	positive regulation of meiosis (GO:0045836)	3.07027864
46	serotonin metabolic process (GO:0042428)	3.05061593
47	organic cation transport (GO:0015695)	3.02224299
48	L-fucose catabolic process (GO:0042355)	3.01160840
49	fucose catabolic process (GO:0019317)	3.01160840
50	L-fucose metabolic process (GO:0042354)	3.01160840
51	regulation of rhodopsin mediated signaling pathway (GO:0022400)	3.00964575
52	L-alpha-amino acid transmembrane transport (GO:1902475)	2.99512521
53	retinal ganglion cell axon guidance (GO:0031290)	2.98586935
54	postsynaptic membrane organization (GO:0001941)	2.97945672
55	centriole replication (GO:0007099)	2.94493868
56	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	2.93229331
57	organelle disassembly (GO:1903008)	2.92707829
58	epithelial cilium movement (GO:0003351)	2.91903275
59	establishment of protein localization to Golgi (GO:0072600)	2.91579982
60	iron coordination entity transport (GO:1901678)	2.91432891
61	proline transport (GO:0015824)	2.88783965
62	mesenchymal cell differentiation (GO:0048762)	2.86218974
63	protein targeting to Golgi (GO:0000042)	2.84125457
64	aromatic amino acid family catabolic process (GO:0009074)	2.84048626
65	glycerol metabolic process (GO:0006071)	2.83481834
66	serotonin receptor signaling pathway (GO:0007210)	2.83458867
67	positive regulation of meiotic cell cycle (GO:0051446)	2.82100432
68	presynaptic membrane organization (GO:0097090)	2.80769838
69	regulation of transforming growth factor beta2 production (GO:0032909)	2.79915933
70	platelet dense granule organization (GO:0060155)	2.78003469
71	rhodopsin mediated signaling pathway (GO:0016056)	2.77683421
72	intra-Golgi vesicle-mediated transport (GO:0006891)	2.77464219
73	regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)	2.77206640
74	aromatic amino acid family metabolic process (GO:0009072)	2.76249782
75	cofactor transport (GO:0051181)	2.74706713
76	protein polyglutamylation (GO:0018095)	2.73752046
77	tachykinin receptor signaling pathway (GO:0007217)	2.72649528
78	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.72570503
79	primary amino compound metabolic process (GO:1901160)	2.68673783
80	sulfur compound transport (GO:0072348)	2.68637596
81	regulation of gonadotropin secretion (GO:0032276)	2.68366392
82	organ induction (GO:0001759)	2.68268993
83	norepinephrine metabolic process (GO:0042415)	2.68124705
84	regulation of cell proliferation involved in heart morphogenesis (GO:2000136)	2.67636879
85	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	2.67124170
86	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	2.67124170
87	behavioral response to ethanol (GO:0048149)	2.66947892
88	cardiac right ventricle morphogenesis (GO:0003215)	2.66940031
89	negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)	2.64393201
90	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.63532249
91	protein localization to Golgi apparatus (GO:0034067)	2.63188901
92	negative regulation of glycoprotein metabolic process (GO:1903019)	2.62192610
93	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.62159253
94	innervation (GO:0060384)	2.61603046
95	sympathetic nervous system development (GO:0048485)	2.61177694
96	gamma-aminobutyric acid signaling pathway (GO:0007214)	2.58392007
97	flavonoid metabolic process (GO:0009812)	2.50633080
98	somite rostral/caudal axis specification (GO:0032525)	2.50360391
99	indolalkylamine metabolic process (GO:0006586)	2.49869172
100	toxin transport (GO:1901998)	2.47681937

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IGF1R_20145208_ChIP-Seq_DFB_Human	4.30468108
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.40979876
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.28948024
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.02886055
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.84920891
6	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.81407726
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.69631033
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.68952046
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.62492879
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.29132438
11	* P300_19829295_ChIP-Seq_ESCs_Human	2.27979102
12	* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.95399564
13	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.93825962
14	AR_21572438_ChIP-Seq_LNCaP_Human	1.92455342
15	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.91908008
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.89673357
17	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.81082203
18	ER_23166858_ChIP-Seq_MCF-7_Human	1.80549093
19	FUS_26573619_Chip-Seq_HEK293_Human	1.79037175
20	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.76982253
21	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.75011325
22	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.70980025
23	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.70913064
24	SMAD4_21799915_ChIP-Seq_A2780_Human	1.68895070
25	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.65488883
26	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.64284043
27	TCF4_23295773_ChIP-Seq_U87_Human	1.61847346
28	STAT3_23295773_ChIP-Seq_U87_Human	1.60840850
29	VDR_22108803_ChIP-Seq_LS180_Human	1.60227912
30	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.58445902
31	TAF15_26573619_Chip-Seq_HEK293_Human	1.55208101
32	* SOX2_19829295_ChIP-Seq_ESCs_Human	1.51402909
33	* NANOG_19829295_ChIP-Seq_ESCs_Human	1.51402909
34	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.51205138
35	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.51143739
36	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.50953268
37	CBP_20019798_ChIP-Seq_JUKART_Human	1.48103804
38	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.48103804
39	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.41272033
40	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.40579577
41	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.38627830
42	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.38535503
43	* AR_25329375_ChIP-Seq_VCAP_Human	1.37062624
44	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.35432942
45	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.33846278
46	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.33690673
47	HOXB7_26014856_ChIP-Seq_BT474_Human	1.32255825
48	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.30120103
49	BCAT_22108803_ChIP-Seq_LS180_Human	1.28121655
50	* TCF4_22108803_ChIP-Seq_LS180_Human	1.27329398
51	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.26645579
52	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.24740350
53	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.23675846
54	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.23675846
55	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.23217433
56	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.22672038
57	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.22628323
58	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.22628323
59	EZH2_22144423_ChIP-Seq_EOC_Human	1.20790510
60	CDX2_22108803_ChIP-Seq_LS180_Human	1.20723523
61	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.20639134
62	TP53_18474530_ChIP-ChIP_U2OS_Human	1.18904655
63	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.18081184
64	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.16144525
65	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.16023805
66	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.16007063
67	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.14833919
68	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.14745859
69	TP53_22573176_ChIP-Seq_HFKS_Human	1.13945110
70	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.13117533
71	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.12642808
72	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.12407143
73	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.11578177
74	RNF2_27304074_Chip-Seq_NSC_Mouse	1.11129395
75	* NCOR_22424771_ChIP-Seq_293T_Human	1.10641076
76	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.09562961
77	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.08515981
78	RUNX2_22187159_ChIP-Seq_PCA_Human	1.08433905
79	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.05957264
80	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.04943498
81	* NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.04226860
82	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.03346467
83	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.03232137
84	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.03065148
85	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.03041370
86	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.02677521
87	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	1.01294257
88	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.00281967
89	AR_20517297_ChIP-Seq_VCAP_Human	0.99538524
90	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.98917589
91	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.98848717
92	AR_19668381_ChIP-Seq_PC3_Human	0.97858683
93	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.97233792
94	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.96178412
95	KDM2B_26808549_Chip-Seq_REH_Human	0.95487596
96	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.95435819
97	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.95079042
98	EWS_26573619_Chip-Seq_HEK293_Human	0.94563648
99	CJUN_26792858_Chip-Seq_BT549_Human	0.93258141
100	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.93107809

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002837_dystrophic_cardiac_calcinosis	7.64860289
2	MP0005171_absent_coat_pigmentation	5.34191730
3	MP0002653_abnormal_ependyma_morphology	4.98776289
4	MP0003136_yellow_coat_color	4.60268450
5	MP0003045_fibrosis	3.15814060
6	MP0000569_abnormal_digit_pigmentation	3.06215913
7	MP0001984_abnormal_olfaction	2.79219445
8	MP0003195_calcinosis	2.76054433
9	MP0003890_abnormal_embryonic-extraembry	2.56229636
10	MP0003879_abnormal_hair_cell	2.54617125
11	MP0003646_muscle_fatigue	2.51675767
12	MP0005379_endocrine/exocrine_gland_phen	2.51616086
13	MP0002254_reproductive_system_inflammat	2.38245100
14	MP0005646_abnormal_pituitary_gland	2.13233510
15	MP0009780_abnormal_chondrocyte_physiolo	1.97476623
16	MP0006072_abnormal_retinal_apoptosis	1.86759424
17	MP0003880_abnormal_central_pattern	1.82362876
18	MP0002938_white_spotting	1.80063018
19	MP0000427_abnormal_hair_cycle	1.73676352
20	MP0002876_abnormal_thyroid_physiology	1.70337260
21	MP0005503_abnormal_tendon_morphology	1.62634684
22	MP0002168_other_aberrant_phenotype	1.58670847
23	MP0005551_abnormal_eye_electrophysiolog	1.52223578
24	MP0005253_abnormal_eye_physiology	1.51487315
25	MP0005377_hearing/vestibular/ear_phenot	1.46743502
26	MP0003878_abnormal_ear_physiology	1.46743502
27	MP0005085_abnormal_gallbladder_physiolo	1.43233049
28	MP0003122_maternal_imprinting	1.42069553
29	MP0005365_abnormal_bile_salt	1.39773122
30	MP0002909_abnormal_adrenal_gland	1.39097168
31	MP0008872_abnormal_physiological_respon	1.33086848
32	MP0009745_abnormal_behavioral_response	1.33046376
33	MP0005075_abnormal_melanosome_morpholog	1.30687511
34	MP0002272_abnormal_nervous_system	1.19841574
35	MP0001501_abnormal_sleep_pattern	1.18283413
36	MP0004381_abnormal_hair_follicle	1.17796269
37	MP0002095_abnormal_skin_pigmentation	1.17488904
38	MP0003787_abnormal_imprinting	1.16610867
39	MP0003011_delayed_dark_adaptation	1.15596441
40	MP0002075_abnormal_coat/hair_pigmentati	1.14965304
41	MP0010329_abnormal_lipoprotein_level	1.14802618
42	MP0004147_increased_porphyrin_level	1.10037460
43	MP0005448_abnormal_energy_balance	1.06978295
44	MP0004270_analgesia	1.04378396
45	MP0002163_abnormal_gland_morphology	1.03831447
46	MP0005645_abnormal_hypothalamus_physiol	1.03385575
47	MP0002160_abnormal_reproductive_system	1.02999328
48	MP0002751_abnormal_autonomic_nervous	1.01855622
49	MP0005670_abnormal_white_adipose	1.01459878
50	MP0002638_abnormal_pupillary_reflex	1.01106171
51	MP0006054_spinal_hemorrhage	1.00568412
52	MP0004043_abnormal_pH_regulation	1.00553415
53	MP0000015_abnormal_ear_pigmentation	1.00272331
54	MP0003137_abnormal_impulse_conducting	0.97382080
55	MP0009046_muscle_twitch	0.95182601
56	MP0001529_abnormal_vocalization	0.94616881
57	MP0002102_abnormal_ear_morphology	0.93978962
58	MP0002064_seizures	0.92833516
59	MP0002733_abnormal_thermal_nociception	0.91967106
60	MP0001486_abnormal_startle_reflex	0.91957421
61	MP0001324_abnormal_eye_pigmentation	0.91136323
62	MP0005220_abnormal_exocrine_pancreas	0.90965524
63	MP0002229_neurodegeneration	0.90097920
64	MP0008875_abnormal_xenobiotic_pharmacok	0.88808801
65	MP0008877_abnormal_DNA_methylation	0.85461993
66	MP0005174_abnormal_tail_pigmentation	0.85367900
67	MP0001970_abnormal_pain_threshold	0.83793530
68	MP0010352_gastrointestinal_tract_polyps	0.83740201
69	MP0001485_abnormal_pinna_reflex	0.83281274
70	MP0000749_muscle_degeneration	0.82607964
71	MP0002971_abnormal_brown_adipose	0.82444462
72	MP0006276_abnormal_autonomic_nervous	0.81269966
73	MP0005395_other_phenotype	0.79932445
74	MP0002184_abnormal_innervation	0.79473059
75	MP0001968_abnormal_touch/_nociception	0.79425743
76	MP0000778_abnormal_nervous_system	0.78271125
77	MP0005389_reproductive_system_phenotype	0.77772255
78	MP0001186_pigmentation_phenotype	0.77277525
79	MP0002557_abnormal_social/conspecific_i	0.77231249
80	MP0002572_abnormal_emotion/affect_behav	0.76340404
81	MP0004142_abnormal_muscle_tone	0.76159557
82	MP0003937_abnormal_limbs/digits/tail_de	0.74086156
83	MP0009115_abnormal_fat_cell	0.73251543
84	MP0001944_abnormal_pancreas_morphology	0.71753444
85	MP0002693_abnormal_pancreas_physiology	0.70896468
86	MP0001963_abnormal_hearing_physiology	0.68664612
87	MP0002138_abnormal_hepatobiliary_system	0.68180010
88	MP0002735_abnormal_chemical_nociception	0.67977514
89	MP0009697_abnormal_copulation	0.67615604
90	MP0000631_abnormal_neuroendocrine_gland	0.65988064
91	MP0004085_abnormal_heartbeat	0.65795173
92	MP0005332_abnormal_amino_acid	0.64860482
93	MP0001756_abnormal_urination	0.64466670
94	MP0002078_abnormal_glucose_homeostasis	0.63881978
95	MP0000026_abnormal_inner_ear	0.63876323
96	MP0004885_abnormal_endolymph	0.63779534
97	MP0002734_abnormal_mechanical_nocicepti	0.63153131
98	MP0010386_abnormal_urinary_bladder	0.62816213
99	MP0004133_heterotaxia	0.62694187
100	MP0008789_abnormal_olfactory_epithelium	0.61955964

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Focal motor seizures (HP:0011153)	5.94524652
2	Amelogenesis imperfecta (HP:0000705)	5.48657750
3	Acanthocytosis (HP:0001927)	4.81407120
4	Abnormality of aromatic amino acid family metabolism (HP:0004338)	4.64496585
5	Overlapping toe (HP:0001845)	4.42372637
6	Dialeptic seizures (HP:0011146)	4.23511463
7	Pancreatic cysts (HP:0001737)	3.84034944
8	Pendular nystagmus (HP:0012043)	3.40650837
9	Abnormal albumin level (HP:0012116)	3.34358573
10	Hypoalbuminemia (HP:0003073)	3.34358573
11	Parakeratosis (HP:0001036)	3.28118567
12	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	3.24443746
13	Medial flaring of the eyebrow (HP:0010747)	3.12370062
14	Focal seizures (HP:0007359)	3.11962490
15	Hematochezia (HP:0002573)	3.10012996
16	Congenital stationary night blindness (HP:0007642)	2.86837494
17	Severe visual impairment (HP:0001141)	2.84220718
18	Nephronophthisis (HP:0000090)	2.81607822
19	Tubular atrophy (HP:0000092)	2.81158246
20	Congenital primary aphakia (HP:0007707)	2.80635132
21	Abnormality of the renal cortex (HP:0011035)	2.79574543
22	Gait imbalance (HP:0002141)	2.77482845
23	Colon cancer (HP:0003003)	2.69771789
24	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.68986280
25	Bilateral sensorineural hearing impairment (HP:0008619)	2.67480257
26	Abnormality of the renal medulla (HP:0100957)	2.64041592
27	Large for gestational age (HP:0001520)	2.61718383
28	Chronic diarrhea (HP:0002028)	2.60363357
29	Nephrogenic diabetes insipidus (HP:0009806)	2.53160404
30	Cystic liver disease (HP:0006706)	2.53097549
31	Proximal amyotrophy (HP:0007126)	2.51653726
32	Hemiparesis (HP:0001269)	2.47465784
33	Pancreatic fibrosis (HP:0100732)	2.42776500
34	Epidermoid cyst (HP:0200040)	2.42324198
35	Vaginal atresia (HP:0000148)	2.42040234
36	Genital tract atresia (HP:0001827)	2.37751144
37	Retinitis pigmentosa (HP:0000510)	2.37618804
38	Thyroid-stimulating hormone excess (HP:0002925)	2.28845904
39	Hypokalemia (HP:0002900)	2.28825774
40	Pancreatic islet-cell hyperplasia (HP:0004510)	2.28202997
41	Polydipsia (HP:0001959)	2.27361267
42	Abnormal drinking behavior (HP:0030082)	2.27361267
43	Decreased circulating renin level (HP:0003351)	2.26314913
44	Abnormality of midbrain morphology (HP:0002418)	2.20851778
45	Molar tooth sign on MRI (HP:0002419)	2.20851778
46	Albinism (HP:0001022)	2.20590480
47	Hyperinsulinemic hypoglycemia (HP:0000825)	2.18895818
48	Disproportionate short-trunk short stature (HP:0003521)	2.16669695
49	Cerebellar dysplasia (HP:0007033)	2.15266878
50	Type I transferrin isoform profile (HP:0003642)	2.13766468
51	Inability to walk (HP:0002540)	2.13646546
52	Abnormal glycosylation (HP:0012345)	2.13324768
53	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.13324768
54	Abnormal protein N-linked glycosylation (HP:0012347)	2.13324768
55	Abnormal protein glycosylation (HP:0012346)	2.13324768
56	Short foot (HP:0001773)	2.06086400
57	Type II lissencephaly (HP:0007260)	2.04615593
58	Hypothermia (HP:0002045)	2.04280022
59	True hermaphroditism (HP:0010459)	2.03881185
60	Abnormal rod and cone electroretinograms (HP:0008323)	2.02667141
61	Hypomagnesemia (HP:0002917)	2.00910977
62	Double outlet right ventricle (HP:0001719)	2.00878503
63	Congenital malformation of the right heart (HP:0011723)	2.00878503
64	Tarsal synostosis (HP:0008368)	2.00680407
65	Proximal tubulopathy (HP:0000114)	2.00273257
66	Abnormality of macular pigmentation (HP:0008002)	1.97877212
67	Abolished electroretinogram (ERG) (HP:0000550)	1.96764492
68	Difficulty walking (HP:0002355)	1.94968462
69	Poor coordination (HP:0002370)	1.94921364
70	Hypoproteinemia (HP:0003075)	1.93938698
71	Furrowed tongue (HP:0000221)	1.91091324
72	Hyperaldosteronism (HP:0000859)	1.89738378
73	Hypoplastic iliac wings (HP:0002866)	1.89603601
74	Ketoacidosis (HP:0001993)	1.89557442
75	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.88013617
76	Nuclear cataract (HP:0100018)	1.87888579
77	Chorioretinal coloboma (HP:0000567)	1.84593930
78	Rectal prolapse (HP:0002035)	1.84407553
79	Progressive inability to walk (HP:0002505)	1.81772467
80	Synostosis involving bones of the lower limbs (HP:0009138)	1.80702646
81	Synostosis involving bones of the feet (HP:0009140)	1.80702646
82	Absence seizures (HP:0002121)	1.80206879
83	Attenuation of retinal blood vessels (HP:0007843)	1.78457912
84	Polyuria (HP:0000103)	1.77503022
85	Horizontal nystagmus (HP:0000666)	1.75699548
86	Retinal atrophy (HP:0001105)	1.75424959
87	Gaze-evoked nystagmus (HP:0000640)	1.75266588
88	Keratoconus (HP:0000563)	1.74894729
89	Increased corneal curvature (HP:0100692)	1.74894729
90	Tubulointerstitial fibrosis (HP:0005576)	1.72174745
91	Spontaneous hematomas (HP:0007420)	1.71891753
92	Ulnar claw (HP:0001178)	1.70374955
93	Aplastic anemia (HP:0001915)	1.70017902
94	Delayed puberty (HP:0000823)	1.68682207
95	Increased CSF protein (HP:0002922)	1.68326302
96	Progressive cerebellar ataxia (HP:0002073)	1.66929548
97	Bony spicule pigmentary retinopathy (HP:0007737)	1.66015719
98	Abnormality of potassium homeostasis (HP:0011042)	1.65055091
99	Poikilocytosis (HP:0004447)	1.63626417
100	Labial hypoplasia (HP:0000066)	1.62460467

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	LATS1	8.05208765
2	STK38L	6.40228238
3	FRK	4.32143368
4	LATS2	3.94796679
5	WNK3	3.69942921
6	PRKD3	2.74933929
7	ZAK	2.38284035
8	STK38	2.34520539
9	NLK	2.25205912
10	MAP3K4	2.19635988
11	ACVR1B	2.12450057
12	STK3	2.03677598
13	PINK1	1.77020012
14	EPHA4	1.64623891
15	BMPR1B	1.50169725
16	CSNK1A1L	1.44083918
17	ADRBK2	1.35981216
18	MAP2K7	1.35833338
19	GRK1	1.33931066
20	PAK3	1.31502905
21	MAP2K2	1.30992770
22	OXSR1	1.19458688
23	EPHA3	1.11714671
24	KSR2	1.08209970
25	MELK	1.07198887
26	FER	1.06971824
27	MAP4K2	1.03974313
28	MAP3K2	1.01100617
29	TGFBR2	0.97850407
30	CASK	0.93974147
31	PDPK1	0.91045217
32	PRKCE	0.89361810
33	PRKAA2	0.87545421
34	CDK19	0.83159045
35	DAPK2	0.80147500
36	CSNK1G3	0.74127294
37	BMX	0.73578959
38	PLK2	0.68580623
39	CSNK1G1	0.65055370
40	BRSK2	0.64409432
41	CSNK1G2	0.64380687
42	TNK2	0.61754921
43	NEK2	0.59783631
44	LIMK1	0.59603681
45	EPHB1	0.59578543
46	STK39	0.59198774
47	TAOK3	0.57541948
48	MAP2K4	0.56065256
49	MAPK13	0.55101125
50	TGFBR1	0.54961338
51	CAMKK2	0.53986813
52	PRKCG	0.53673095
53	INSRR	0.52446099
54	GRK7	0.51697878
55	CAMK2D	0.50849697
56	EIF2AK3	0.50657967
57	PRKD1	0.50590554
58	PTK2B	0.50191075
59	MAP2K6	0.50088210
60	PRKCI	0.49907161
61	WNK4	0.49563070
62	ADRBK1	0.46517841
63	PAK6	0.44048803
64	TAF1	0.41797332
65	STK11	0.40266239
66	IRAK1	0.39105183
67	YES1	0.38679517
68	PIK3CG	0.36920344
69	FGFR2	0.35897797
70	PHKG2	0.35865375
71	PHKG1	0.35865375
72	BCR	0.35682115
73	KSR1	0.35575381
74	MAP2K1	0.34657372
75	CSNK1D	0.32886692
76	MKNK2	0.32597106
77	CAMK2A	0.31953783
78	PRKACA	0.30282838
79	AKT2	0.30202716
80	GRK5	0.27983406
81	STK16	0.27657310
82	TLK1	0.27485643
83	PLK3	0.27349824
84	NTRK3	0.25929695
85	MARK1	0.25199057
86	CSNK1A1	0.24010101
87	PRKG2	0.23620331
88	MAPK15	0.22579734
89	JAK2	0.22395047
90	CDK5	0.22190451
91	UHMK1	0.22160911
92	PDGFRB	0.21831826
93	PDK1	0.21810740
94	CHUK	0.20847612
95	TIE1	0.19599578
96	ABL1	0.19157460
97	CAMK4	0.19009501
98	MET	0.17372813
99	NUAK1	0.16256398
100	CAMK2B	0.15767525

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	5.06653262
2	Phototransduction_Homo sapiens_hsa04744	3.91221572
3	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.56411645
4	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	3.15165320
5	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.60440608
6	Sphingolipid metabolism_Homo sapiens_hsa00600	2.60235025
7	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.31112502
8	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.23220064
9	Nicotine addiction_Homo sapiens_hsa05033	2.11259280
10	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.04773103
11	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.88930644
12	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.83095777
13	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.82085788
14	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.78957261
15	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.74088532
16	Collecting duct acid secretion_Homo sapiens_hsa04966	1.68574737
17	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.65985586
18	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.65247384
19	Insulin secretion_Homo sapiens_hsa04911	1.64176924
20	Nitrogen metabolism_Homo sapiens_hsa00910	1.61918941
21	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.59434015
22	Butanoate metabolism_Homo sapiens_hsa00650	1.53812253
23	Folate biosynthesis_Homo sapiens_hsa00790	1.52258336
24	Protein export_Homo sapiens_hsa03060	1.50200868
25	Circadian rhythm_Homo sapiens_hsa04710	1.43862581
26	Taste transduction_Homo sapiens_hsa04742	1.43486329
27	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.42836325
28	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.39074762
29	GABAergic synapse_Homo sapiens_hsa04727	1.38528851
30	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.30383772
31	Morphine addiction_Homo sapiens_hsa05032	1.28379527
32	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.23240207
33	Tryptophan metabolism_Homo sapiens_hsa00380	1.13780914
34	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.07919509
35	Phenylalanine metabolism_Homo sapiens_hsa00360	1.07386959
36	Olfactory transduction_Homo sapiens_hsa04740	0.96952869
37	Ether lipid metabolism_Homo sapiens_hsa00565	0.95184973
38	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.93798128
39	Caffeine metabolism_Homo sapiens_hsa00232	0.93224303
40	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.91739785
41	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.91070775
42	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.90256353
43	ABC transporters_Homo sapiens_hsa02010	0.89688546
44	Peroxisome_Homo sapiens_hsa04146	0.85625344
45	beta-Alanine metabolism_Homo sapiens_hsa00410	0.85272900
46	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.82306998
47	Steroid biosynthesis_Homo sapiens_hsa00100	0.81997151
48	Serotonergic synapse_Homo sapiens_hsa04726	0.80916756
49	Pyruvate metabolism_Homo sapiens_hsa00620	0.79223235
50	Histidine metabolism_Homo sapiens_hsa00340	0.77107365
51	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.76949077
52	Propanoate metabolism_Homo sapiens_hsa00640	0.75103383
53	Glutamatergic synapse_Homo sapiens_hsa04724	0.71430919
54	Calcium signaling pathway_Homo sapiens_hsa04020	0.70411275
55	Selenocompound metabolism_Homo sapiens_hsa00450	0.69640946
56	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.67776800
57	Bile secretion_Homo sapiens_hsa04976	0.64413848
58	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.63864148
59	One carbon pool by folate_Homo sapiens_hsa00670	0.62930489
60	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.62777148
61	Oxidative phosphorylation_Homo sapiens_hsa00190	0.60754348
62	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.59570417
63	Metabolic pathways_Homo sapiens_hsa01100	0.59300462
64	Basal transcription factors_Homo sapiens_hsa03022	0.58103751
65	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.57316436
66	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.57048771
67	Fatty acid elongation_Homo sapiens_hsa00062	0.56919701
68	Adherens junction_Homo sapiens_hsa04520	0.56198533
69	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.55146223
70	Fatty acid degradation_Homo sapiens_hsa00071	0.53913613
71	Sulfur metabolism_Homo sapiens_hsa00920	0.52312872
72	cAMP signaling pathway_Homo sapiens_hsa04024	0.52274557
73	Fatty acid metabolism_Homo sapiens_hsa01212	0.51887785
74	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.51763282
75	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.51246648
76	Circadian entrainment_Homo sapiens_hsa04713	0.50299406
77	Chemical carcinogenesis_Homo sapiens_hsa05204	0.49761287
78	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.49686816
79	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.49377870
80	Retinol metabolism_Homo sapiens_hsa00830	0.48871212
81	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.47179311
82	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.45136921
83	Glycerolipid metabolism_Homo sapiens_hsa00561	0.44942840
84	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.44638458
85	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.44210728
86	Hippo signaling pathway_Homo sapiens_hsa04390	0.44164757
87	Regulation of autophagy_Homo sapiens_hsa04140	0.43311623
88	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.43290974
89	Salivary secretion_Homo sapiens_hsa04970	0.41298072
90	Vibrio cholerae infection_Homo sapiens_hsa05110	0.41236467
91	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.41042922
92	Tyrosine metabolism_Homo sapiens_hsa00350	0.39588506
93	Linoleic acid metabolism_Homo sapiens_hsa00591	0.39431080
94	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.39381768
95	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.37350001
96	RNA polymerase_Homo sapiens_hsa03020	0.34035372
97	Arginine and proline metabolism_Homo sapiens_hsa00330	0.31964520
98	Type II diabetes mellitus_Homo sapiens_hsa04930	0.29986605
99	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.29077624
100	Oocyte meiosis_Homo sapiens_hsa04114	0.28981849

C10ORF113

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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