C10ORF120

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromosome condensation (GO:0030261)9.86302270
2response to pheromone (GO:0019236)9.73266819
3DNA packaging (GO:0006323)9.36225516
4sperm capacitation (GO:0048240)9.30014901
5spermatid nucleus differentiation (GO:0007289)8.91808921
6single strand break repair (GO:0000012)8.69384941
7plasma membrane fusion (GO:0045026)8.46194305
8microtubule depolymerization (GO:0007019)8.15057201
9spermatid development (GO:0007286)8.03892487
10sperm-egg recognition (GO:0035036)7.67610501
11multicellular organism reproduction (GO:0032504)7.46332959
12binding of sperm to zona pellucida (GO:0007339)7.35645725
13reproduction (GO:0000003)7.09097295
14sexual reproduction (GO:0019953)7.03713483
15calcium ion-dependent exocytosis (GO:0017156)6.65791044
16negative regulation of inclusion body assembly (GO:0090084)6.63267665
17microtubule polymerization or depolymerization (GO:0031109)6.55075621
18rRNA methylation (GO:0031167)6.48071566
19cell-cell recognition (GO:0009988)6.32135686
20protein polyglutamylation (GO:0018095)6.21725732
21spermatogenesis (GO:0007283)6.15074719
22male gamete generation (GO:0048232)6.12978003
23axonemal dynein complex assembly (GO:0070286)5.95289108
24microtubule severing (GO:0051013)5.94466127
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.79754710
26phosphatidylethanolamine biosynthetic process (GO:0006646)5.78958183
27cellular ketone body metabolic process (GO:0046950)5.77884260
28protein targeting to Golgi (GO:0000042)5.69757510
29centriole replication (GO:0007099)5.64095767
30gamete generation (GO:0007276)5.63685061
31establishment of protein localization to Golgi (GO:0072600)5.46114793
32rRNA modification (GO:0000154)5.40514752
33phosphatidylethanolamine metabolic process (GO:0046337)5.34826757
34retrograde transport, vesicle recycling within Golgi (GO:0000301)5.30160945
35ketone body metabolic process (GO:1902224)5.09460192
36single fertilization (GO:0007338)4.94541018
37regulation of Rab GTPase activity (GO:0032313)4.93642978
38positive regulation of Rab GTPase activity (GO:0032851)4.93642978
39chromatin silencing (GO:0006342)4.90689155
40germ cell development (GO:0007281)4.81897452
41centriole assembly (GO:0098534)4.80542412
42motile cilium assembly (GO:0044458)4.68720141
43regulation of inclusion body assembly (GO:0090083)4.66431978
44regulation of cilium movement (GO:0003352)4.60353826
45cellular process involved in reproduction in multicellular organism (GO:0022412)4.57202379
46multicellular organismal reproductive process (GO:0048609)4.50946893
47RNA destabilization (GO:0050779)4.50371145
48nucleus organization (GO:0006997)4.46188710
49cilium or flagellum-dependent cell motility (GO:0001539)4.33576391
50fertilization (GO:0009566)4.19876341
51regulation of transcription involved in cell fate commitment (GO:0060850)4.16403671
52coenzyme catabolic process (GO:0009109)4.08237927
53cell wall macromolecule catabolic process (GO:0016998)4.07498376
54protein localization to Golgi apparatus (GO:0034067)4.05404420
55glycerol ether metabolic process (GO:0006662)3.87813987
56regulation of centriole replication (GO:0046599)3.84524870
57cell wall macromolecule metabolic process (GO:0044036)3.84356345
58negative regulation of Rho protein signal transduction (GO:0035024)3.83473697
59epithelial cilium movement (GO:0003351)3.73341750
60ether metabolic process (GO:0018904)3.57413532
61negative regulation of histone methylation (GO:0031061)3.56691568
62response to acidic pH (GO:0010447)3.55892271
63cerebral cortex neuron differentiation (GO:0021895)3.55260126
64seminiferous tubule development (GO:0072520)3.53662623
65peptidyl-threonine dephosphorylation (GO:0035970)3.49783232
66regulation of female gonad development (GO:2000194)3.46890164
67histone H3-K9 demethylation (GO:0033169)3.45628175
68cellular response to pH (GO:0071467)3.38177600
69polyamine biosynthetic process (GO:0006596)3.35953533
70piRNA metabolic process (GO:0034587)3.32669740
71negative regulation of gene expression, epigenetic (GO:0045814)3.32410020
72cilium movement (GO:0003341)3.31716336
73cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.30092316
74organic cation transport (GO:0015695)3.29188594
75protein-DNA complex disassembly (GO:0032986)3.24663785
76nucleosome disassembly (GO:0006337)3.24663785
77mesenchymal cell differentiation involved in kidney development (GO:0072161)3.24627916
78mesenchymal cell differentiation involved in renal system development (GO:2001012)3.24627916
79regulation of interleukin-13 production (GO:0032656)3.22213041
80multicellular organismal movement (GO:0050879)3.17456473
81musculoskeletal movement (GO:0050881)3.17456473
82regulation of microtubule-based movement (GO:0060632)3.12032026
83cell differentiation involved in metanephros development (GO:0072202)3.05704178
84multicellular organismal development (GO:0007275)3.03203556
85DNA methylation involved in gamete generation (GO:0043046)3.00590634
86cell recognition (GO:0008037)3.00580617
87DNA conformation change (GO:0071103)2.99934107
88positive regulation of endothelial cell differentiation (GO:0045603)2.99714363
89cranial nerve morphogenesis (GO:0021602)2.99617152
90protein depolymerization (GO:0051261)2.99207318
91negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.98769913
92histone exchange (GO:0043486)2.96875238
93regulation of T-helper 2 cell differentiation (GO:0045628)2.96295412
94homeostasis of number of cells within a tissue (GO:0048873)2.93636003
95male meiosis I (GO:0007141)2.93508248
96glomerular visceral epithelial cell development (GO:0072015)2.92053887
97membrane protein intracellular domain proteolysis (GO:0031293)2.89608046
98acrosome reaction (GO:0007340)12.2158642
99sperm motility (GO:0030317)11.1750582
100fusion of sperm to egg plasma membrane (GO:0007342)11.1489524

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.60692837
2EZH2_22144423_ChIP-Seq_EOC_Human3.69436712
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.51157259
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.49983261
5POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.48369819
6TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.48369819
7IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.33395745
8CBP_20019798_ChIP-Seq_JUKART_Human2.33395745
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.19829187
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.01055719
11ERA_21632823_ChIP-Seq_H3396_Human1.97950418
12NANOG_20526341_ChIP-Seq_ESCs_Human1.97630632
13ELF1_20517297_ChIP-Seq_JURKAT_Human1.95907259
14CTBP1_25329375_ChIP-Seq_LNCAP_Human1.95873475
15VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.90786637
16DROSHA_22980978_ChIP-Seq_HELA_Human1.90361403
17UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.89850478
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.86634004
19RAC3_21632823_ChIP-Seq_H3396_Human1.82546846
20WDR5_24793694_ChIP-Seq_LNCAP_Human1.82146075
21FUS_26573619_Chip-Seq_HEK293_Human1.80376394
22RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.78741890
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.73581509
24* EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.70040094
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.67185386
26EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.63537295
27TAF2_19829295_ChIP-Seq_ESCs_Human1.62815338
28BCL6_27268052_Chip-Seq_Bcells_Human1.62717039
29AUTS2_25519132_ChIP-Seq_293T-REX_Human1.61305070
30ARNT_22903824_ChIP-Seq_MCF-7_Human1.60887526
31CTCF_27219007_Chip-Seq_Bcells_Human1.60457282
32SMAD4_21741376_ChIP-Seq_EPCs_Human1.60297459
33* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.59817763
34E2F1_20622854_ChIP-Seq_HELA_Human1.59104373
35MYC_19829295_ChIP-Seq_ESCs_Human1.55659164
36ER_23166858_ChIP-Seq_MCF-7_Human1.55549336
37TDRD3_21172665_ChIP-Seq_MCF-7_Human1.54955157
38YY1_22570637_ChIP-Seq_MALME-3M_Human1.54077846
39BCOR_27268052_Chip-Seq_Bcells_Human1.52555633
40AR_25329375_ChIP-Seq_VCAP_Human1.51858321
41CTCF_20526341_ChIP-Seq_ESCs_Human1.49498085
42SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48425720
43PHF8_20622854_ChIP-Seq_HELA_Human1.47745541
44P68_20966046_ChIP-Seq_HELA_Human1.44297815
45OCT4_20526341_ChIP-Seq_ESCs_Human1.43011709
46SMC4_20622854_ChIP-Seq_HELA_Human1.42982267
47TP53_18474530_ChIP-ChIP_U2OS_Human1.40363124
48* TP63_22573176_ChIP-Seq_HFKS_Human1.37233726
49GATA3_21878914_ChIP-Seq_MCF-7_Human1.35799341
50SUZ12_27294783_Chip-Seq_ESCs_Mouse1.34962917
51SMAD3_21741376_ChIP-Seq_ESCs_Human1.34737961
52BP1_19119308_ChIP-ChIP_Hs578T_Human1.34713142
53TP63_19390658_ChIP-ChIP_HaCaT_Human1.34609396
54SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.34150418
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34059298
56P300_27268052_Chip-Seq_Bcells_Human1.32952252
57ETV2_25802403_ChIP-Seq_MESCs_Mouse1.32856566
58KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.32296980
59TAF15_26573619_Chip-Seq_HEK293_Human1.30125307
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.29905602
61SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29877085
62P300_19829295_ChIP-Seq_ESCs_Human1.29621661
63ERG_20517297_ChIP-Seq_VCAP_Human1.28661948
64P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.28602558
65PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.28291011
66RUNX_20019798_ChIP-Seq_JUKART_Human1.27412588
67CBX2_22325352_ChIP-Seq_293T-Rex_Human1.26267166
68SMRT_27268052_Chip-Seq_Bcells_Human1.22670141
69EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.22187610
70NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.22137635
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21190493
72RBPJ_21746931_ChIP-Seq_IB4_Human1.20984233
73SMAD4_21741376_ChIP-Seq_HESCs_Human1.20551701
74SOX2_22085726_ChIP-Seq_NPCs_Mouse1.20464040
75CEBPB_22108803_ChIP-Seq_LS180_Human1.19903560
76ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16808409
77P53_21459846_ChIP-Seq_SAOS-2_Human1.16419850
78ETV1_20927104_ChIP-Seq_GIST48_Human1.15589908
79RUNX2_22187159_ChIP-Seq_PCA_Human1.15578734
80* HNFA_21074721_ChIP-Seq_CACO-2_Human1.15378277
81LXR_22292898_ChIP-Seq_THP-1_Human1.14205465
82EZH2_27294783_Chip-Seq_ESCs_Mouse1.12488241
83NFYB_21822215_ChIP-Seq_K562_Human1.10902871
84KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10050054
85RUNX1_26923725_Chip-Seq_HPCs_Mouse1.09845337
86PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.09524527
87PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09239255
88* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.07365853
89ZNF274_21170338_ChIP-Seq_K562_Hela1.07247526
90HOXB7_26014856_ChIP-Seq_BT474_Human1.04691581
91OCT1_27270436_Chip-Seq_PROSTATE_Human1.04510806
92GF1_26923725_Chip-Seq_HPCs_Mouse1.02586571
93ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.02512336
94E2F1_17053090_ChIP-ChIP_MCF-7_Human1.02352623
95SMAD4_21799915_ChIP-Seq_A2780_Human1.01709796
96* SOX2_19829295_ChIP-Seq_ESCs_Human0.99792519
97* NANOG_19829295_ChIP-Seq_ESCs_Human0.99792519
98FOXH1_21741376_ChIP-Seq_EPCs_Human0.98787784
99* TBL1_22424771_ChIP-Seq_293T_Human0.98763918
100KLF4_19829295_ChIP-Seq_ESCs_Human0.97992229

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive4.48606837
2MP0005377_hearing/vestibular/ear_phenot4.31004372
3MP0003878_abnormal_ear_physiology4.31004372
4MP0001929_abnormal_gametogenesis4.04613169
5MP0005670_abnormal_white_adipose3.96274197
6MP0003718_maternal_effect3.73957135
7MP0001348_abnormal_lacrimal_gland3.51056352
8MP0000678_abnormal_parathyroid_gland2.82311640
9MP0002161_abnormal_fertility/fecundity2.68557726
10MP0002234_abnormal_pharynx_morphology2.29595320
11MP0003011_delayed_dark_adaptation2.22402149
12MP0002132_abnormal_respiratory_system2.07459159
13MP0005410_abnormal_fertilization12.4680147
14MP0002210_abnormal_sex_determination1.96262367
15MP0008877_abnormal_DNA_methylation1.92150254
16MP0002138_abnormal_hepatobiliary_system1.78065693
17MP0002249_abnormal_larynx_morphology1.70846428
18MP0005423_abnormal_somatic_nervous1.70033606
19MP0005379_endocrine/exocrine_gland_phen1.69120708
20MP0003646_muscle_fatigue1.69015772
21MP0005395_other_phenotype1.62106504
22MP0001145_abnormal_male_reproductive1.59649673
23MP0000653_abnormal_sex_gland1.56258242
24MP0001486_abnormal_startle_reflex1.35644091
25MP0006292_abnormal_olfactory_placode1.32663566
26MP0003879_abnormal_hair_cell1.32503284
27MP0004510_myositis1.30926194
28MP0002282_abnormal_trachea_morphology1.28390745
29MP0002127_abnormal_cardiovascular_syste1.27337639
30MP0002735_abnormal_chemical_nociception1.25516447
31MP0009053_abnormal_anal_canal1.20930662
32MP0001485_abnormal_pinna_reflex1.15934081
33MP0001765_abnormal_ion_homeostasis1.15143380
34MP0008789_abnormal_olfactory_epithelium1.14750092
35MP0005310_abnormal_salivary_gland1.14331958
36MP0001963_abnormal_hearing_physiology1.08535135
37MP0004742_abnormal_vestibular_system1.07737042
38MP0000534_abnormal_ureter_morphology1.07397684
39MP0001968_abnormal_touch/_nociception1.04817495
40MP0000049_abnormal_middle_ear1.00435688
41MP0005248_abnormal_Harderian_gland0.99446891
42MP0004859_abnormal_synaptic_plasticity0.99195337
43MP0000026_abnormal_inner_ear0.98255600
44MP0005394_taste/olfaction_phenotype0.90269879
45MP0005499_abnormal_olfactory_system0.90269879
46MP0000681_abnormal_thyroid_gland0.90251088
47MP0008995_early_reproductive_senescence0.89333142
48MP0002229_neurodegeneration0.87526531
49MP0003699_abnormal_female_reproductive0.86398023
50MP0002822_catalepsy0.83926239
51MP0005551_abnormal_eye_electrophysiolog0.78037540
52MP0000516_abnormal_urinary_system0.76952089
53MP0005367_renal/urinary_system_phenotyp0.76952089
54MP0001879_abnormal_lymphatic_vessel0.76409834
55MP0003077_abnormal_cell_cycle0.74210276
56MP0003119_abnormal_digestive_system0.73524740
57MP0004085_abnormal_heartbeat0.71084890
58MP0002733_abnormal_thermal_nociception0.68126793
59MP0000955_abnormal_spinal_cord0.68021555
60MP0000566_synostosis0.67370333
61MP0002067_abnormal_sensory_capabilities0.65955111
62MP0001666_abnormal_nutrient_absorption0.62642230
63MP0002272_abnormal_nervous_system0.62060634
64MP0008569_lethality_at_weaning0.59540348
65MP0001984_abnormal_olfaction0.58856509
66MP0009115_abnormal_fat_cell0.58667074
67MP0005647_abnormal_sex_gland0.56888104
68MP0005636_abnormal_mineral_homeostasis0.56114510
69MP0002557_abnormal_social/conspecific_i0.54452585
70MP0002572_abnormal_emotion/affect_behav0.50344685
71MP0005666_abnormal_adipose_tissue0.50203616
72MP0005253_abnormal_eye_physiology0.47986189
73MP0003936_abnormal_reproductive_system0.46282321
74MP0002734_abnormal_mechanical_nocicepti0.45729649
75MP0001293_anophthalmia0.44700700
76MP0005375_adipose_tissue_phenotype0.44384647
77MP0001905_abnormal_dopamine_level0.43405204
78MP0004484_altered_response_of0.42977477
79MP0000470_abnormal_stomach_morphology0.41820231
80MP0009745_abnormal_behavioral_response0.41204306
81MP0003880_abnormal_central_pattern0.40712082
82MP0005535_abnormal_body_temperature0.40402860
83MP0001970_abnormal_pain_threshold0.39905450
84MP0005167_abnormal_blood-brain_barrier0.39779985
85MP0001119_abnormal_female_reproductive0.39698252
86MP0002928_abnormal_bile_duct0.39270534
87MP0005083_abnormal_biliary_tract0.38745503
88MP0003137_abnormal_impulse_conducting0.37384490
89MP0000613_abnormal_salivary_gland0.37176934
90MP0001501_abnormal_sleep_pattern0.35304456
91MP0002653_abnormal_ependyma_morphology0.35298295
92MP0000003_abnormal_adipose_tissue0.33740614
93MP0009697_abnormal_copulation0.33191787
94MP0005408_hypopigmentation0.32048372
95MP0008961_abnormal_basal_metabolism0.31866834
96MP0004233_abnormal_muscle_weight0.30718972
97MP0003635_abnormal_synaptic_transmissio0.30252029
98MP0010368_abnormal_lymphatic_system0.29832944
99MP0005451_abnormal_body_composition0.29375619
100MP0000467_abnormal_esophagus_morphology0.29330982

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)8.65920347
2Absent/shortened dynein arms (HP:0200106)5.94962729
3Dynein arm defect of respiratory motile cilia (HP:0012255)5.94962729
4Attenuation of retinal blood vessels (HP:0007843)5.26943994
5Bony spicule pigmentary retinopathy (HP:0007737)5.22488781
6Abnormal ciliary motility (HP:0012262)4.79222658
7Male infertility (HP:0003251)4.73793493
8Infertility (HP:0000789)4.72579428
9Asymmetric septal hypertrophy (HP:0001670)4.66251702
10Abnormal respiratory motile cilium physiology (HP:0012261)4.57411839
11Azoospermia (HP:0000027)4.53620471
12Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.34815378
13Abnormal respiratory motile cilium morphology (HP:0005938)4.27126889
14Abnormal respiratory epithelium morphology (HP:0012253)4.27126889
15Resting tremor (HP:0002322)4.25820771
16Abnormal rod and cone electroretinograms (HP:0008323)4.24701858
17Tubulointerstitial nephritis (HP:0001970)4.18008830
18Bell-shaped thorax (HP:0001591)4.15074662
19Hypoplastic ischia (HP:0003175)4.14915078
20Abnormal spermatogenesis (HP:0008669)4.10227612
21Hyperkalemia (HP:0002153)3.93218108
22Facial shape deformation (HP:0011334)3.84280848
23Potter facies (HP:0002009)3.84280848
24Nasal polyposis (HP:0100582)3.83697096
25Abnormality of macular pigmentation (HP:0008002)3.78478584
26Enlarged epiphyses (HP:0010580)3.70076882
27Abnormality of the ischium (HP:0003174)3.65321625
28Impulsivity (HP:0100710)3.61696521
29Chronic hepatic failure (HP:0100626)3.56299662
30Aplasia/Hypoplasia of the earlobes (HP:0009906)3.51005421
31Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.49241141
32Cone-rod dystrophy (HP:0000548)3.32833928
33Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.23726033
34Unilateral renal agenesis (HP:0000122)3.19049579
35Abnormality of the nasal mucosa (HP:0000433)3.11836809
36Osteomalacia (HP:0002749)3.09784914
37Generalized aminoaciduria (HP:0002909)3.06991579
38Congenital malformation of the right heart (HP:0011723)2.94809077
39Double outlet right ventricle (HP:0001719)2.94809077
40Rhinitis (HP:0012384)2.79663237
41Postural instability (HP:0002172)2.77982285
42Abnormality of the aortic arch (HP:0012303)2.69978498
43Renal dysplasia (HP:0000110)2.68737281
44Hypoplasia of the thymus (HP:0000778)2.62515890
45Progressive sensorineural hearing impairment (HP:0000408)2.55037979
46Truncal obesity (HP:0001956)2.53946481
47Abnormal urine output (HP:0012590)2.52202405
48Sensory axonal neuropathy (HP:0003390)2.49240168
49Hypophosphatemic rickets (HP:0004912)2.49156877
50Stage 5 chronic kidney disease (HP:0003774)2.47583290
51Nephronophthisis (HP:0000090)2.39555067
52Abnormality of potassium homeostasis (HP:0011042)2.36043879
53Abnormality of the parathyroid morphology (HP:0011766)2.33166091
54Progressive cerebellar ataxia (HP:0002073)2.26290046
55Transposition of the great arteries (HP:0001669)2.22010773
56Abnormal connection of the cardiac segments (HP:0011545)2.22010773
57Abnormal ventriculo-arterial connection (HP:0011563)2.22010773
58Epiphyseal dysplasia (HP:0002656)2.21687258
59Hypoplastic left heart (HP:0004383)2.21177941
60Hypoalphalipoproteinemia (HP:0003233)2.21007404
61Abnormality of renal excretion (HP:0011036)2.20879152
62Absent epiphyses (HP:0010577)2.12692116
63Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.12692116
64Abnormality of the costochondral junction (HP:0000919)2.12643904
65Hyponatremia (HP:0002902)2.08347292
66Flattened epiphyses (HP:0003071)2.08336402
67Abnormality of the pubic bones (HP:0003172)2.08220812
68Abnormality of the renal medulla (HP:0100957)2.04040283
69Portal hypertension (HP:0001409)2.01549017
70Bronchiectasis (HP:0002110)2.00563315
71Ventricular tachycardia (HP:0004756)2.00135047
72Abnormal drinking behavior (HP:0030082)1.99728462
73Polydipsia (HP:0001959)1.99728462
74Optic nerve hypoplasia (HP:0000609)1.98325516
75Hypoplastic heart (HP:0001961)1.98220024
76Aplasia/Hypoplasia of the sacrum (HP:0008517)1.96678867
77Myokymia (HP:0002411)1.95709071
78Tubulointerstitial abnormality (HP:0001969)1.95418017
79Polyuria (HP:0000103)1.94518284
80Abnormality of dental color (HP:0011073)1.93196349
81Abnormality of the epiphysis of the femoral head (HP:0010574)1.92459999
82Insulin-resistant diabetes mellitus (HP:0000831)1.91455711
83Focal segmental glomerulosclerosis (HP:0000097)1.91170068
84Amelogenesis imperfecta (HP:0000705)1.91030429
85Tetany (HP:0001281)1.90275960
86Decreased central vision (HP:0007663)1.90141058
87Median cleft lip (HP:0000161)1.86346002
88Abdominal situs inversus (HP:0003363)1.83739456
89Abnormality of abdominal situs (HP:0011620)1.83739456
90Short ribs (HP:0000773)1.82703691
91Abnormality of the hepatic vasculature (HP:0006707)1.81598912
92Congenital sensorineural hearing impairment (HP:0008527)1.80824635
93Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.78667152
94Abnormality of femoral epiphyses (HP:0006499)1.78667152
95Renovascular hypertension (HP:0100817)1.77504554
96Peripheral hypomyelination (HP:0007182)1.76852444
97Chronic bronchitis (HP:0004469)1.76722492
98Menstrual irregularities (HP:0000858)1.76199114
99Hyperthyroidism (HP:0000836)1.75599181
100Flat capital femoral epiphysis (HP:0003370)1.74653076

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK47.73428702
2TESK16.18515926
3DDR25.22515411
4MAP4K24.02720063
5INSRR3.66385995
6STK383.18247083
7PLK22.73092198
8BRD42.60148462
9MAP3K92.49256032
10PNCK2.33778460
11MAPK152.19970637
12PRKD32.11764936
13STK38L2.10016693
14WNK11.98508919
15CAMK1G1.87038323
16NEK61.73363177
17KSR21.65789122
18PDPK11.62266948
19CDK71.61456308
20ARAF1.55999199
21MST1R1.53073699
22PDK11.51206519
23PIK3CG1.47263119
24BRAF1.44065268
25CDK121.42186369
26MAP3K131.25207079
27DYRK1B1.22984986
28PTK2B0.98379318
29LATS20.89604178
30AKT30.88157968
31MAP3K80.81085027
32PRKG10.75260192
33MET0.72402317
34PRKAA20.72252172
35UHMK10.69940882
36RPS6KA20.66856543
37CAMK1D0.63990069
38STK390.63798521
39PRKG20.62975643
40RPS6KA10.58396559
41BMPR1B0.57122638
42TIE10.55296454
43MOS0.54097744
44CDK20.53641055
45ROCK10.52048271
46MAP2K20.51159906
47MAP3K110.50943939
48CDK90.50050828
49MUSK0.49553376
50CDK40.49258013
51WNK40.49083757
52CAMK10.49004389
53GSK3B0.46981094
54CDK10.46196160
55CDK30.45892481
56TYRO30.45053701
57LATS10.43108313
58MAPK10.43000549
59MAP3K20.41351117
60AURKA0.39773989
61CHEK10.38994392
62PRKCZ0.38837682
63SIK20.38508188
64MTOR0.37052409
65MAP3K10.36707846
66NTRK30.36337861
67CAMK40.33286520
68RPS6KC10.32188740
69RPS6KL10.32188740
70MAPK80.31180616
71RPS6KA60.30901431
72SGK4940.30601697
73SGK2230.30601697
74PRKCG0.29362885
75TNIK0.29053840
76ACVR1B0.27338803
77PKN10.26280166
78SGK10.24401056
79OXSR10.24220262
80BRSK10.23823435
81MAPK100.22046683
82MAP3K40.20558726
83MARK20.20257909
84MAPK140.19706638
85PRKCB0.18868859
86MARK10.16908102
87CHUK0.16786356
88PRKACA0.16737318
89TNK20.16724101
90TESK20.16679148
91AKT10.15168582
92ZAK0.14203709
93CAMK2A0.13491581
94IKBKB0.13325859
95PRKACB0.13083538
96MAPK110.12920589
97PLK10.11328627
98NTRK20.11246003
99NEK20.10381420
100NUAK10.09384370

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000728.46754633
2Fatty acid biosynthesis_Homo sapiens_hsa000615.05218454
3Olfactory transduction_Homo sapiens_hsa047404.01533668
4Butanoate metabolism_Homo sapiens_hsa006502.71934927
5Allograft rejection_Homo sapiens_hsa053302.15244839
6Dorso-ventral axis formation_Homo sapiens_hsa043202.10495977
7Autoimmune thyroid disease_Homo sapiens_hsa053202.08468638
8Type I diabetes mellitus_Homo sapiens_hsa049402.01276244
9Graft-versus-host disease_Homo sapiens_hsa053321.91555876
10Glycerophospholipid metabolism_Homo sapiens_hsa005641.89933357
11Antigen processing and presentation_Homo sapiens_hsa046121.75535368
12Taste transduction_Homo sapiens_hsa047421.74731362
13RNA transport_Homo sapiens_hsa030131.51195935
14Oocyte meiosis_Homo sapiens_hsa041141.44321426
15Basal transcription factors_Homo sapiens_hsa030221.43068447
16Arginine and proline metabolism_Homo sapiens_hsa003301.42854063
17Type II diabetes mellitus_Homo sapiens_hsa049301.42468991
18Phenylalanine metabolism_Homo sapiens_hsa003601.34652843
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.33776405
20Viral myocarditis_Homo sapiens_hsa054161.32573599
21Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.28000040
22Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.18933751
23Phototransduction_Homo sapiens_hsa047441.17805313
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.16744557
25Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.16126484
26Fatty acid degradation_Homo sapiens_hsa000711.14203649
27Fatty acid metabolism_Homo sapiens_hsa012121.08610245
28Endocytosis_Homo sapiens_hsa041441.06113050
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.04739234
30Protein digestion and absorption_Homo sapiens_hsa049741.03210164
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02712131
32Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.00430753
33Morphine addiction_Homo sapiens_hsa050320.97336699
34Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.96587376
35Inositol phosphate metabolism_Homo sapiens_hsa005620.94611579
36Salivary secretion_Homo sapiens_hsa049700.94376767
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.89713609
38Cardiac muscle contraction_Homo sapiens_hsa042600.89281514
39cAMP signaling pathway_Homo sapiens_hsa040240.87527134
40Nicotine addiction_Homo sapiens_hsa050330.87088289
41Arginine biosynthesis_Homo sapiens_hsa002200.83425612
42ABC transporters_Homo sapiens_hsa020100.81934616
43Calcium signaling pathway_Homo sapiens_hsa040200.79389633
44Influenza A_Homo sapiens_hsa051640.76202358
45Adipocytokine signaling pathway_Homo sapiens_hsa049200.74125513
46Synaptic vesicle cycle_Homo sapiens_hsa047210.73800599
47Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70319521
48PPAR signaling pathway_Homo sapiens_hsa033200.66416113
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66382651
50Fat digestion and absorption_Homo sapiens_hsa049750.65510604
51Renin-angiotensin system_Homo sapiens_hsa046140.64389608
52Estrogen signaling pathway_Homo sapiens_hsa049150.63866164
53Circadian entrainment_Homo sapiens_hsa047130.63666105
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.61692389
55Hedgehog signaling pathway_Homo sapiens_hsa043400.61377028
56Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60768717
57Caffeine metabolism_Homo sapiens_hsa002320.60369649
58Aldosterone synthesis and secretion_Homo sapiens_hsa049250.57830758
59Retinol metabolism_Homo sapiens_hsa008300.56596197
60Bile secretion_Homo sapiens_hsa049760.56488331
61Tyrosine metabolism_Homo sapiens_hsa003500.50618885
62Purine metabolism_Homo sapiens_hsa002300.50610868
63Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.49732745
64Maturity onset diabetes of the young_Homo sapiens_hsa049500.48018323
65MAPK signaling pathway_Homo sapiens_hsa040100.47573762
66Fanconi anemia pathway_Homo sapiens_hsa034600.45634935
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.45383719
68Glutamatergic synapse_Homo sapiens_hsa047240.45379204
69Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44436866
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43964685
71Renin secretion_Homo sapiens_hsa049240.43417504
72Insulin secretion_Homo sapiens_hsa049110.42753842
73Viral carcinogenesis_Homo sapiens_hsa052030.42162766
74mRNA surveillance pathway_Homo sapiens_hsa030150.41751366
75Selenocompound metabolism_Homo sapiens_hsa004500.41353718
76Glycerolipid metabolism_Homo sapiens_hsa005610.40842828
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.40713747
78Serotonergic synapse_Homo sapiens_hsa047260.40263464
79Gastric acid secretion_Homo sapiens_hsa049710.38027037
80GABAergic synapse_Homo sapiens_hsa047270.36001999
81Tight junction_Homo sapiens_hsa045300.34042306
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.33128379
83Circadian rhythm_Homo sapiens_hsa047100.33121063
84Cholinergic synapse_Homo sapiens_hsa047250.32698154
85VEGF signaling pathway_Homo sapiens_hsa043700.32533949
86Acute myeloid leukemia_Homo sapiens_hsa052210.31451637
87Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.30976625
88Herpes simplex infection_Homo sapiens_hsa051680.30713005
89Cell cycle_Homo sapiens_hsa041100.29224703
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28081870
91Oxytocin signaling pathway_Homo sapiens_hsa049210.27741320
92Jak-STAT signaling pathway_Homo sapiens_hsa046300.22653057
93Base excision repair_Homo sapiens_hsa034100.20321403
94Pancreatic secretion_Homo sapiens_hsa049720.18282364
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.18161045
96Long-term potentiation_Homo sapiens_hsa047200.17119249
97RNA degradation_Homo sapiens_hsa030180.15425948
98Propanoate metabolism_Homo sapiens_hsa006400.13679083
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.13598823
100Linoleic acid metabolism_Homo sapiens_hsa005910.12744301

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