ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of DNA methylation (GO:0044030)	9.31846041
2	chaperone-mediated protein transport (GO:0072321)	8.16248072
3	sperm motility (GO:0030317)	7.94791984
4	acrosome reaction (GO:0007340)	7.94483979
5	fusion of sperm to egg plasma membrane (GO:0007342)	7.33364336
6	glyoxylate metabolic process (GO:0046487)	7.20285307
7	establishment of protein localization to mitochondrial membrane (GO:0090151)	7.17300252
8	ectoderm development (GO:0007398)	7.00404756
9	female gonad development (GO:0008585)	6.53202040
10	male meiosis (GO:0007140)	6.23495818
11	microtubule depolymerization (GO:0007019)	5.89093726
12	chromosome condensation (GO:0030261)	5.74607740
13	plasma membrane fusion (GO:0045026)	5.62781080
14	sperm capacitation (GO:0048240)	5.50338857
15	DNA packaging (GO:0006323)	5.34978792
16	protein polyglutamylation (GO:0018095)	5.33503805
17	sperm-egg recognition (GO:0035036)	5.32945146
18	spermatid development (GO:0007286)	5.32099041
19	protein targeting to Golgi (GO:0000042)	5.27049029
20	response to pheromone (GO:0019236)	5.22510266
21	binding of sperm to zona pellucida (GO:0007339)	5.20376699
22	multicellular organism reproduction (GO:0032504)	5.16411192
23	regulation of telomere maintenance via telomerase (GO:0032210)	5.13323350
24	single strand break repair (GO:0000012)	5.13006046
25	opsonization (GO:0008228)	4.97974793
26	microtubule polymerization or depolymerization (GO:0031109)	4.96472736
27	establishment of protein localization to Golgi (GO:0072600)	4.94547690
28	centrosome duplication (GO:0051298)	4.93029990
29	response to hepatocyte growth factor (GO:0035728)	4.92811699
30	cellular response to hepatocyte growth factor stimulus (GO:0035729)	4.92811699
31	retrograde transport, vesicle recycling within Golgi (GO:0000301)	4.87873155
32	RNA destabilization (GO:0050779)	4.73873901
33	peptidyl-lysine dimethylation (GO:0018027)	4.70560345
34	central nervous system neuron axonogenesis (GO:0021955)	4.69277661
35	reproduction (GO:0000003)	4.62739291
36	negative regulation of telomere maintenance (GO:0032205)	4.52667092
37	positive regulation of macrophage activation (GO:0043032)	4.45877951
38	spermatid nucleus differentiation (GO:0007289)	4.45817366
39	inner mitochondrial membrane organization (GO:0007007)	4.39159436
40	rRNA methylation (GO:0031167)	4.38863952
41	outer ear morphogenesis (GO:0042473)	4.33842240
42	regulation of G0 to G1 transition (GO:0070316)	4.31125798
43	cell-cell recognition (GO:0009988)	4.28285986
44	calcium ion-dependent exocytosis (GO:0017156)	4.26316427
45	negative regulation of inclusion body assembly (GO:0090084)	4.26242016
46	axonemal dynein complex assembly (GO:0070286)	4.04351667
47	cranial suture morphogenesis (GO:0060363)	3.97941030
48	cellular ketone body metabolic process (GO:0046950)	3.97835221
49	spermatogenesis (GO:0007283)	3.97506402
50	male gamete generation (GO:0048232)	3.96244250
51	single fertilization (GO:0007338)	3.95256036
52	positive regulation of respiratory burst (GO:0060267)	3.91923485
53	negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)	3.90012468
54	rRNA modification (GO:0000154)	3.86762934
55	centriole replication (GO:0007099)	3.83752537
56	sexual reproduction (GO:0019953)	3.79298308
57	mitotic G2 DNA damage checkpoint (GO:0007095)	3.73465614
58	ventricular trabecula myocardium morphogenesis (GO:0003222)	3.72442505
59	stress granule assembly (GO:0034063)	3.71336504
60	gamete generation (GO:0007276)	3.69205341
61	intermediate filament cytoskeleton organization (GO:0045104)	3.66260082
62	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.60462801
63	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.60462801
64	regulation of translation, ncRNA-mediated (GO:0045974)	3.60462801
65	intermediate filament-based process (GO:0045103)	3.57628994
66	regulation of protein glycosylation (GO:0060049)	3.55066048
67	ketone body metabolic process (GO:1902224)	3.54343780
68	protein localization to Golgi apparatus (GO:0034067)	3.47574760
69	middle ear morphogenesis (GO:0042474)	3.41990334
70	phospholipid translocation (GO:0045332)	3.39976139
71	lipid translocation (GO:0034204)	3.39976139
72	centriole assembly (GO:0098534)	3.34380606
73	organic cation transport (GO:0015695)	3.31983658
74	thyroid hormone generation (GO:0006590)	3.31007413
75	motile cilium assembly (GO:0044458)	3.26886925
76	acrosome assembly (GO:0001675)	3.23950848
77	mitotic G2/M transition checkpoint (GO:0044818)	3.21014636
78	epithelial cilium movement (GO:0003351)	3.20779034
79	coenzyme catabolic process (GO:0009109)	3.18517748
80	positive regulation of protein import into nucleus, translocation (GO:0033160)	3.15617250
81	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.12956142
82	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.12733968
83	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.12733968
84	regulation of centriole replication (GO:0046599)	3.10628233
85	fertilization (GO:0009566)	3.08627968
86	DNA strand renaturation (GO:0000733)	3.08540602
87	polyamine biosynthetic process (GO:0006596)	3.06396641
88	multicellular organismal reproductive process (GO:0048609)	3.06318915
89	germ cell development (GO:0007281)	3.05917860
90	cellular process involved in reproduction in multicellular organism (GO:0022412)	2.97744234
91	regulation of inclusion body assembly (GO:0090083)	2.96658551
92	regulation of transcription involved in cell fate commitment (GO:0060850)	2.95765289
93	apoptotic DNA fragmentation (GO:0006309)	2.87984740
94	regulation of telomere maintenance (GO:0032204)	2.85860602
95	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)	2.85675514
96	craniofacial suture morphogenesis (GO:0097094)	2.85301495
97	sodium ion export (GO:0071436)	2.81949340
98	thyroid hormone metabolic process (GO:0042403)	2.80760125
99	maintenance of protein location in nucleus (GO:0051457)	2.75074332
100	neurofilament cytoskeleton organization (GO:0060052)	13.0115533

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	3.71683495
2	VDR_22108803_ChIP-Seq_LS180_Human	3.60683184
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.61096716
4	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.56985863
5	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.47432260
6	CBP_20019798_ChIP-Seq_JUKART_Human	2.47432260
7	GBX2_23144817_ChIP-Seq_PC3_Human	2.46849759
8	EZH2_22144423_ChIP-Seq_EOC_Human	2.45924132
9	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.40015524
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.34672081
11	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.23704714
12	AUTS2_25519132_ChIP-Seq_293T-REX_Human	2.18512682
13	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.06353166
14	FUS_26573619_Chip-Seq_HEK293_Human	1.98142033
15	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.95203729
16	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.95203729
17	AR_21572438_ChIP-Seq_LNCaP_Human	1.93003501
18	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.91332307
19	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.89780980
20	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.86659880
21	IRF1_19129219_ChIP-ChIP_H3396_Human	1.83977703
22	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.79528808
23	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.75495961
24	NANOG_20526341_ChIP-Seq_ESCs_Human	1.69552528
25	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.68432539
26	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.65797177
27	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.63978507
28	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.60500229
29	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.59811679
30	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.59367115
31	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.59285568
32	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.58080506
33	CTCF_27219007_Chip-Seq_Bcells_Human	1.53516898
34	AR_25329375_ChIP-Seq_VCAP_Human	1.52790025
35	P300_19829295_ChIP-Seq_ESCs_Human	1.52113712
36	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.49980280
37	ZNF274_21170338_ChIP-Seq_K562_Hela	1.48725856
38	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.47634996
39	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.46978587
40	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.45009170
41	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.44884155
42	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.43108095
43	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.42192416
44	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.41483098
45	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.40785265
46	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.40686375
47	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.38261009
48	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.37418352
49	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.36244843
50	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.34854819
51	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.31990972
52	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.30738498
53	ERA_21632823_ChIP-Seq_H3396_Human	1.29852191
54	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.29532107
55	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.28890299
56	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.25215388
57	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.24302493
58	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.21495886
59	KDM2B_26808549_Chip-Seq_REH_Human	1.21429609
60	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.20998703
61	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.19818334
62	SMAD4_21799915_ChIP-Seq_A2780_Human	1.18417057
63	TAF2_19829295_ChIP-Seq_ESCs_Human	1.17442796
64	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.15946397
65	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.14205151
66	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.14001125
67	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.13897697
68	CBP_21632823_ChIP-Seq_H3396_Human	1.12456346
69	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.12205221
70	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.11952689
71	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.11952689
72	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.11888108
73	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.09697072
74	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.09299325
75	ERG_20517297_ChIP-Seq_VCAP_Human	1.09039521
76	RUNX2_22187159_ChIP-Seq_PCA_Human	1.08323154
77	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.08281810
78	MYC_19829295_ChIP-Seq_ESCs_Human	1.07854849
79	CJUN_26792858_Chip-Seq_BT549_Human	1.07051562
80	RBPJ_21746931_ChIP-Seq_IB4_Human	1.06245468
81	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.05897589
82	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.04483600
83	NFYB_21822215_ChIP-Seq_K562_Human	1.03743675
84	RAC3_21632823_ChIP-Seq_H3396_Human	1.03586473
85	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.02523666
86	TAF15_26573619_Chip-Seq_HEK293_Human	1.02221704
87	TBL1_22424771_ChIP-Seq_293T_Human	1.01039564
88	LXR_22292898_ChIP-Seq_THP-1_Human	1.00671563
89	TP53_18474530_ChIP-ChIP_U2OS_Human	1.00150463
90	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.99432572
91	KLF4_19829295_ChIP-Seq_ESCs_Human	0.97424591
92	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.96980078
93	PHF8_20622853_ChIP-Seq_HELA_Human	0.96626804
94	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.96396020
95	VDR_24787735_ChIP-Seq_THP-1_Human	0.95967587
96	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.95849098
97	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.94816141
98	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.94044839
99	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.93467872
100	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.93106675

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008995_early_reproductive_senescence	7.93552547
2	MP0005410_abnormal_fertilization	7.21238357
3	MP0005670_abnormal_white_adipose	4.33292615
4	MP0003878_abnormal_ear_physiology	3.13196061
5	MP0005377_hearing/vestibular/ear_phenot	3.13196061
6	MP0003698_abnormal_male_reproductive	2.83012920
7	MP0003786_premature_aging	2.75136594
8	MP0001929_abnormal_gametogenesis	2.53717785
9	MP0002653_abnormal_ependyma_morphology	2.38590175
10	MP0004264_abnormal_extraembryonic_tissu	2.34010358
11	MP0005423_abnormal_somatic_nervous	2.32919193
12	MP0002876_abnormal_thyroid_physiology	2.14950698
13	MP0004742_abnormal_vestibular_system	2.12233020
14	MP0001485_abnormal_pinna_reflex	2.01167111
15	MP0002127_abnormal_cardiovascular_syste	1.94951806
16	MP0001348_abnormal_lacrimal_gland	1.82822139
17	MP0002161_abnormal_fertility/fecundity	1.78892684
18	MP0003011_delayed_dark_adaptation	1.75853940
19	MP0003880_abnormal_central_pattern	1.71466603
20	MP0002132_abnormal_respiratory_system	1.68231127
21	MP0003646_muscle_fatigue	1.68159686
22	MP0004885_abnormal_endolymph	1.53806155
23	MP0004859_abnormal_synaptic_plasticity	1.52485018
24	MP0000749_muscle_degeneration	1.50846177
25	MP0002210_abnormal_sex_determination	1.50124847
26	MP0001486_abnormal_startle_reflex	1.48938388
27	MP0004270_analgesia	1.48318853
28	MP0000678_abnormal_parathyroid_gland	1.36507808
29	MP0001968_abnormal_touch/_nociception	1.32149358
30	MP0001986_abnormal_taste_sensitivity	1.30801181
31	MP0003718_maternal_effect	1.30177835
32	MP0002735_abnormal_chemical_nociception	1.27390292
33	MP0000049_abnormal_middle_ear	1.27304212
34	MP0010094_abnormal_chromosome_stability	1.24203715
35	MP0001440_abnormal_grooming_behavior	1.22674145
36	MP0002837_dystrophic_cardiac_calcinosis	1.20325475
37	MP0001905_abnormal_dopamine_level	1.17372167
38	MP0001145_abnormal_male_reproductive	1.16168257
39	MP0000653_abnormal_sex_gland	1.12990086
40	MP0004084_abnormal_cardiac_muscle	1.12595763
41	MP0001849_ear_inflammation	1.09015598
42	MP0002249_abnormal_larynx_morphology	1.07011408
43	MP0005503_abnormal_tendon_morphology	1.06320047
44	MP0004036_abnormal_muscle_relaxation	1.04414536
45	MP0002734_abnormal_mechanical_nocicepti	1.02267239
46	MP0003936_abnormal_reproductive_system	1.00022608
47	MP0002736_abnormal_nociception_after	0.98426317
48	MP0001119_abnormal_female_reproductive	0.97489490
49	MP0006276_abnormal_autonomic_nervous	0.96054394
50	MP0003699_abnormal_female_reproductive	0.94884817
51	MP0001963_abnormal_hearing_physiology	0.93085054
52	MP0002067_abnormal_sensory_capabilities	0.91753652
53	MP0009046_muscle_twitch	0.91629962
54	MP0006082_CNS_inflammation	0.91431588
55	MP0009745_abnormal_behavioral_response	0.89318084
56	MP0000751_myopathy	0.89279881
57	MP0001984_abnormal_olfaction	0.89258784
58	MP0002272_abnormal_nervous_system	0.89178516
59	MP0002282_abnormal_trachea_morphology	0.88945551
60	MP0003879_abnormal_hair_cell	0.85604653
61	MP0005666_abnormal_adipose_tissue	0.85373315
62	MP0005275_abnormal_skin_tensile	0.85293899
63	MP0008877_abnormal_DNA_methylation	0.84021053
64	MP0000026_abnormal_inner_ear	0.81611206
65	MP0003635_abnormal_synaptic_transmissio	0.81310789
66	MP0003137_abnormal_impulse_conducting	0.79393404
67	MP0001666_abnormal_nutrient_absorption	0.76533868
68	MP0003111_abnormal_nucleus_morphology	0.76335236
69	MP0004085_abnormal_heartbeat	0.75506447
70	MP0004510_myositis	0.74618464
71	MP0004019_abnormal_vitamin_homeostasis	0.74352247
72	MP0004215_abnormal_myocardial_fiber	0.74268848
73	MP0002064_seizures	0.73364309
74	MP0002234_abnormal_pharynx_morphology	0.72837419
75	MP0003941_abnormal_skin_development	0.72444242
76	MP0008569_lethality_at_weaning	0.71597525
77	MP0002108_abnormal_muscle_morphology	0.69825012
78	MP0006292_abnormal_olfactory_placode	0.69272899
79	MP0003136_yellow_coat_color	0.69176533
80	MP0002697_abnormal_eye_size	0.68674386
81	MP0008875_abnormal_xenobiotic_pharmacok	0.68481680
82	MP0005551_abnormal_eye_electrophysiolog	0.68209244
83	MP0000955_abnormal_spinal_cord	0.66545031
84	MP0009250_abnormal_appendicular_skeleto	0.66251486
85	MP0009115_abnormal_fat_cell	0.66017878
86	MP0004484_altered_response_of	0.63980618
87	MP0000534_abnormal_ureter_morphology	0.63483770
88	MP0003950_abnormal_plasma_membrane	0.62853666
89	MP0005671_abnormal_response_to	0.60889981
90	MP0003763_abnormal_thymus_physiology	0.60789963
91	MP0005253_abnormal_eye_physiology	0.60760806
92	MP0004272_abnormal_basement_membrane	0.60718757
93	MP0005620_abnormal_muscle_contractility	0.60435533
94	MP0002572_abnormal_emotion/affect_behav	0.59185301
95	MP0008004_abnormal_stomach_pH	0.59092982
96	MP0005166_decreased_susceptibility_to	0.57633994
97	MP0000566_synostosis	0.57100050
98	MP0002557_abnormal_social/conspecific_i	0.53971927
99	MP0006072_abnormal_retinal_apoptosis	0.53484456
100	MP0001881_abnormal_mammary_gland	0.52464562

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Duplicated collecting system (HP:0000081)	9.18982508
2	Chromosomal breakage induced by crosslinking agents (HP:0003221)	8.54935462
3	Abnormality of the renal collecting system (HP:0004742)	8.12984552
4	Chromsome breakage (HP:0040012)	7.38795240
5	Reticulocytopenia (HP:0001896)	7.00867797
6	Abnormality of pyrimidine metabolism (HP:0004353)	6.78097484
7	Abnormality of DNA repair (HP:0003254)	6.10731307
8	Oral leukoplakia (HP:0002745)	5.91618795
9	Ureteral duplication (HP:0000073)	5.40675218
10	Aplastic anemia (HP:0001915)	5.07939203
11	Duplication of thumb phalanx (HP:0009942)	4.98829045
12	Ectopic kidney (HP:0000086)	4.59536321
13	Enlarged epiphyses (HP:0010580)	4.53714632
14	Increased serum pyruvate (HP:0003542)	4.24223273
15	Absent thumb (HP:0009777)	3.88493459
16	Aplasia/Hypoplasia of the uvula (HP:0010293)	3.79910568
17	Abnormality of glycolysis (HP:0004366)	3.64539888
18	Meckel diverticulum (HP:0002245)	3.63428573
19	Abnormality of the ileum (HP:0001549)	3.54947350
20	Abnormality of the preputium (HP:0100587)	3.34545837
21	Flattened epiphyses (HP:0003071)	3.33104033
22	Absent radius (HP:0003974)	3.32883454
23	Aplasia involving forearm bones (HP:0009822)	3.17690273
24	Absent forearm bone (HP:0003953)	3.17690273
25	Renal Fanconi syndrome (HP:0001994)	3.11982258
26	Eosinophilia (HP:0001880)	3.07140103
27	Severe visual impairment (HP:0001141)	3.06431684
28	Hypergonadotropic hypogonadism (HP:0000815)	2.99158637
29	Autoimmune thrombocytopenia (HP:0001973)	2.96464664
30	Horseshoe kidney (HP:0000085)	2.94033468
31	Clubbing of toes (HP:0100760)	2.79751757
32	Pancytopenia (HP:0001876)	2.79577740
33	Absent epiphyses (HP:0010577)	2.69909722
34	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	2.69909722
35	Thyroid-stimulating hormone excess (HP:0002925)	2.65075058
36	Abnormality of the vertebral endplates (HP:0005106)	2.64111311
37	Abnormality of the epiphysis of the femoral head (HP:0010574)	2.62542541
38	Abnormality of nucleobase metabolism (HP:0010932)	2.59713406
39	Abnormality of chromosome stability (HP:0003220)	2.58903972
40	Nasal polyposis (HP:0100582)	2.58719551
41	Asymmetric septal hypertrophy (HP:0001670)	2.57360294
42	Small intestinal stenosis (HP:0012848)	2.56681320
43	Duodenal stenosis (HP:0100867)	2.56681320
44	Abnormality of the carotid arteries (HP:0005344)	2.44517408
45	Abnormality involving the epiphyses of the lower limbs (HP:0006500)	2.42835139
46	Abnormality of femoral epiphyses (HP:0006499)	2.42835139
47	Abnormality of B cell number (HP:0010975)	2.41604979
48	Rough bone trabeculation (HP:0100670)	2.41142055
49	Increased hepatocellular lipid droplets (HP:0006565)	2.40555408
50	Stomach cancer (HP:0012126)	2.40406621
51	Abnormality of the femoral head (HP:0003368)	2.32180697
52	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.28736375
53	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.18684843
54	Absent/shortened dynein arms (HP:0200106)	2.18684843
55	Abnormality of the duodenum (HP:0002246)	2.17904663
56	Abnormality of the nasal mucosa (HP:0000433)	2.17249111
57	Hypoplasia of the capital femoral epiphysis (HP:0003090)	2.14686510
58	Exertional dyspnea (HP:0002875)	2.12766003
59	Granulocytopenia (HP:0001913)	2.11759647
60	Partial duplication of the phalanx of hand (HP:0009999)	2.09646743
61	Renal agenesis (HP:0000104)	2.07379886
62	Abnormal respiratory motile cilium physiology (HP:0012261)	2.06436289
63	Abnormality of T cell number (HP:0011839)	2.06160142
64	Insulin-resistant diabetes mellitus (HP:0000831)	2.04766678
65	Lipid accumulation in hepatocytes (HP:0006561)	2.04542220
66	Spinal cord lesions (HP:0100561)	2.03863746
67	Syringomyelia (HP:0003396)	2.03863746
68	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.03190437
69	Abnormality of urine glucose concentration (HP:0011016)	2.00541022
70	Glycosuria (HP:0003076)	2.00541022
71	Abnormality of renal resorption (HP:0011038)	2.00467864
72	Abnormality of eosinophils (HP:0001879)	1.97088378
73	Short thumb (HP:0009778)	1.92604099
74	Abnormality of the parietal bone (HP:0002696)	1.92305357
75	Infertility (HP:0000789)	1.92225102
76	Cellular immunodeficiency (HP:0005374)	1.89559453
77	Abnormal trabecular bone morphology (HP:0100671)	1.87859249
78	Male infertility (HP:0003251)	1.85740463
79	Abnormal ciliary motility (HP:0012262)	1.84980932
80	Abnormality of reticulocytes (HP:0004312)	1.84508211
81	Epiphyseal dysplasia (HP:0002656)	1.83041535
82	Bone marrow hypocellularity (HP:0005528)	1.82850847
83	Truncal obesity (HP:0001956)	1.81645955
84	Facial shape deformation (HP:0011334)	1.80313519
85	Potter facies (HP:0002009)	1.80313519
86	Respiratory distress (HP:0002098)	1.80085338
87	Autoimmune hemolytic anemia (HP:0001890)	1.79989813
88	Resting tremor (HP:0002322)	1.79629524
89	Congenital sensorineural hearing impairment (HP:0008527)	1.78342984
90	Progressive cerebellar ataxia (HP:0002073)	1.77732760
91	Renal cortical cysts (HP:0000803)	1.76513207
92	Bell-shaped thorax (HP:0001591)	1.75910879
93	Tracheoesophageal fistula (HP:0002575)	1.75368083
94	Leukopenia (HP:0001882)	1.72568343
95	Turricephaly (HP:0000262)	1.71364402
96	Triphalangeal thumb (HP:0001199)	1.69768916
97	Generalized aminoaciduria (HP:0002909)	1.67061984
98	Joint swelling (HP:0001386)	1.62174139
99	Abnormal respiratory motile cilium morphology (HP:0005938)	1.59185367
100	Abnormal respiratory epithelium morphology (HP:0012253)	1.59185367

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K1	6.25476775
2	TXK	6.16104022
3	PLK4	3.81782526
4	BCKDK	3.27292742
5	TESK1	2.59217625
6	DDR2	2.55391265
7	INSRR	2.14384726
8	TAOK3	10.7977843
9	PINK1	1.60556123
10	TESK2	1.39041333
11	PLK2	1.31703553
12	OBSCN	1.23813818
13	ZAP70	1.16728160
14	MAPK15	1.12142260
15	MAP4K2	1.10994179
16	CAMK1G	1.04071418
17	BRD4	1.03786344
18	PNCK	0.95748545
19	LATS2	0.90144165
20	STK38	0.86887537
21	SGK1	0.84154941
22	TYRO3	0.82640576
23	NLK	0.76862424
24	CAMK1D	0.74500145
25	PIK3CG	0.73654601
26	TIE1	0.73646529
27	ZAK	0.71264383
28	STK38L	0.71102839
29	WNK1	0.66949116
30	PRPF4B	0.66773374
31	GRK5	0.60498931
32	NME1	0.55830089
33	BMPR1B	0.55122469
34	MYLK	0.54732857
35	SGK223	0.53823573
36	SGK494	0.53823573
37	TNIK	0.53081421
38	MAP3K10	0.50573346
39	CASK	0.42894612
40	JAK1	0.42385020
41	SGK2	0.41843599
42	PRKG2	0.41662924
43	MUSK	0.41537694
44	PRKD3	0.40851608
45	IKBKE	0.40531965
46	DYRK2	0.39667847
47	DYRK3	0.39633686
48	CAMK1	0.39329614
49	TRIM28	0.36887283
50	WNK3	0.34596684
51	MARK3	0.34589901
52	BUB1	0.33831286
53	PRKCG	0.33521776
54	TBK1	0.32298199
55	PRKG1	0.32016591
56	ATR	0.30316700
57	RPS6KA1	0.29769040
58	CSNK1A1	0.28269508
59	PDPK1	0.28001939
60	GRK7	0.27606362
61	PRKAA2	0.27033772
62	GRK1	0.27005971
63	MAP3K9	0.26861612
64	MAPK13	0.26554617
65	MTOR	0.26192514
66	MARK1	0.24874970
67	ADRBK2	0.24222677
68	ROCK1	0.23747102
69	PLK3	0.23459265
70	CDK3	0.23328460
71	CDC7	0.22300388
72	PIK3CA	0.22224278
73	PDK1	0.21296738
74	CAMK2A	0.20279096
75	PTK2B	0.19873396
76	UHMK1	0.19740959
77	PBK	0.19656658
78	MKNK2	0.19422136
79	MAPK8	0.18904059
80	EPHA4	0.18597900
81	TLK1	0.18184946
82	IGF1R	0.17071656
83	PHKG1	0.16722175
84	PHKG2	0.16722175
85	PRKAA1	0.16417853
86	CDK1	0.16313933
87	CDK7	0.16258992
88	PKN1	0.16033513
89	RPS6KA5	0.15890742
90	VRK1	0.15731338
91	MAPK1	0.15476369
92	AKT1	0.15186284
93	CSNK1G1	0.14639146
94	PRKCE	0.14207433
95	PRKCB	0.13721661
96	SGK3	0.13248078
97	SYK	0.12718827
98	LIMK1	0.12461127
99	WEE1	0.12390054
100	TTK	0.11534079

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	4.35809005
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.88096386
3	Fatty acid biosynthesis_Homo sapiens_hsa00061	3.15281479
4	Olfactory transduction_Homo sapiens_hsa04740	2.61350826
5	Pyruvate metabolism_Homo sapiens_hsa00620	2.56952999
6	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.42028577
7	Cardiac muscle contraction_Homo sapiens_hsa04260	2.21597942
8	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.14387155
9	Butanoate metabolism_Homo sapiens_hsa00650	1.98211398
10	Propanoate metabolism_Homo sapiens_hsa00640	1.91735187
11	Oxidative phosphorylation_Homo sapiens_hsa00190	1.79871710
12	Allograft rejection_Homo sapiens_hsa05330	1.77258030
13	Taste transduction_Homo sapiens_hsa04742	1.73045189
14	Type I diabetes mellitus_Homo sapiens_hsa04940	1.72548529
15	Fanconi anemia pathway_Homo sapiens_hsa03460	1.70593190
16	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.70464126
17	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.63658946
18	Parkinsons disease_Homo sapiens_hsa05012	1.57618101
19	Graft-versus-host disease_Homo sapiens_hsa05332	1.52356834
20	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.51951350
21	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.45220463
22	Glutamatergic synapse_Homo sapiens_hsa04724	1.43871891
23	Basal transcription factors_Homo sapiens_hsa03022	1.40498181
24	Morphine addiction_Homo sapiens_hsa05032	1.40455266
25	Salivary secretion_Homo sapiens_hsa04970	1.39239080
26	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.38987197
27	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.33851739
28	Protein digestion and absorption_Homo sapiens_hsa04974	1.33501113
29	Nicotine addiction_Homo sapiens_hsa05033	1.29490425
30	Circadian entrainment_Homo sapiens_hsa04713	1.28244515
31	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.27867063
32	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.27741385
33	Phenylalanine metabolism_Homo sapiens_hsa00360	1.26457973
34	Gastric acid secretion_Homo sapiens_hsa04971	1.20566949
35	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.17602016
36	Mismatch repair_Homo sapiens_hsa03430	1.16863056
37	Huntingtons disease_Homo sapiens_hsa05016	1.16761670
38	Pancreatic secretion_Homo sapiens_hsa04972	1.08717060
39	Alzheimers disease_Homo sapiens_hsa05010	1.06202377
40	Galactose metabolism_Homo sapiens_hsa00052	1.06066788
41	Nitrogen metabolism_Homo sapiens_hsa00910	1.02382205
42	GABAergic synapse_Homo sapiens_hsa04727	0.98815858
43	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.95879684
44	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.92238166
45	Calcium signaling pathway_Homo sapiens_hsa04020	0.92190256
46	Viral myocarditis_Homo sapiens_hsa05416	0.91641672
47	Proteasome_Homo sapiens_hsa03050	0.90603267
48	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.88227001
49	Fatty acid degradation_Homo sapiens_hsa00071	0.86319270
50	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.85182715
51	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.84606550
52	Arginine and proline metabolism_Homo sapiens_hsa00330	0.80448432
53	cAMP signaling pathway_Homo sapiens_hsa04024	0.78192112
54	Serotonergic synapse_Homo sapiens_hsa04726	0.78165545
55	Phototransduction_Homo sapiens_hsa04744	0.76519541
56	Tyrosine metabolism_Homo sapiens_hsa00350	0.76463115
57	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.76032028
58	Antigen processing and presentation_Homo sapiens_hsa04612	0.75372943
59	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.74529700
60	Linoleic acid metabolism_Homo sapiens_hsa00591	0.72531192
61	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.72315413
62	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.70097676
63	Bile secretion_Homo sapiens_hsa04976	0.69762664
64	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.68058136
65	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.67816177
66	Retinol metabolism_Homo sapiens_hsa00830	0.66368605
67	RNA transport_Homo sapiens_hsa03013	0.65706513
68	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.65293299
69	Arginine biosynthesis_Homo sapiens_hsa00220	0.60674815
70	Renin secretion_Homo sapiens_hsa04924	0.59721677
71	Amphetamine addiction_Homo sapiens_hsa05031	0.59709697
72	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.59661295
73	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.58434373
74	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.57628961
75	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.56952672
76	PPAR signaling pathway_Homo sapiens_hsa03320	0.56663340
77	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.56387434
78	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.56330734
79	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.55458251
80	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.54570223
81	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.50850172
82	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.50628032
83	Purine metabolism_Homo sapiens_hsa00230	0.48738506
84	Insulin secretion_Homo sapiens_hsa04911	0.47367970
85	ECM-receptor interaction_Homo sapiens_hsa04512	0.45224661
86	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.44836280
87	Fat digestion and absorption_Homo sapiens_hsa04975	0.44304722
88	Protein export_Homo sapiens_hsa03060	0.44095675
89	Cholinergic synapse_Homo sapiens_hsa04725	0.43633792
90	Fatty acid metabolism_Homo sapiens_hsa01212	0.43241651
91	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.42870085
92	Gap junction_Homo sapiens_hsa04540	0.41806299
93	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.40611278
94	Oocyte meiosis_Homo sapiens_hsa04114	0.39855978
95	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.39748727
96	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.38019280
97	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.35941395
98	Chemical carcinogenesis_Homo sapiens_hsa05204	0.35073922
99	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.34993282
100	Tryptophan metabolism_Homo sapiens_hsa00380	0.33542822

C10ORF142

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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