C10ORF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.22864167
2mitotic chromosome condensation (GO:0007076)5.19632921
3nuclear pore complex assembly (GO:0051292)5.13665978
4mitotic metaphase plate congression (GO:0007080)4.61677821
5nuclear pore organization (GO:0006999)4.50425299
6ribosome assembly (GO:0042255)4.44930460
7DNA strand elongation involved in DNA replication (GO:0006271)4.39123267
8protein localization to chromosome, centromeric region (GO:0071459)4.33167249
9formation of translation preinitiation complex (GO:0001731)4.32049406
10DNA strand elongation (GO:0022616)4.29927984
11ribosomal small subunit biogenesis (GO:0042274)4.27315315
12mitotic sister chromatid segregation (GO:0000070)4.19388090
13regulation of translational fidelity (GO:0006450)4.14378649
14regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.14083218
15mitotic sister chromatid cohesion (GO:0007064)4.09258667
16establishment of integrated proviral latency (GO:0075713)4.05807587
17maturation of SSU-rRNA (GO:0030490)4.05400516
18ribosome biogenesis (GO:0042254)4.02345910
19protein complex localization (GO:0031503)4.01588939
20negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.00445413
21ribonucleoprotein complex biogenesis (GO:0022613)3.88002983
22mitotic nuclear envelope disassembly (GO:0007077)3.87777841
23sister chromatid segregation (GO:0000819)3.84819211
24DNA replication initiation (GO:0006270)3.84699673
25pore complex assembly (GO:0046931)3.79855767
26protein localization to kinetochore (GO:0034501)3.77690809
27telomere maintenance via semi-conservative replication (GO:0032201)3.76375721
28cellular protein complex localization (GO:0034629)3.68024229
29metaphase plate congression (GO:0051310)3.67531980
30spliceosomal tri-snRNP complex assembly (GO:0000244)3.66916368
31regulation of translational termination (GO:0006449)3.65766297
32nuclear envelope disassembly (GO:0051081)3.62036823
33membrane disassembly (GO:0030397)3.62036823
34transcription from mitochondrial promoter (GO:0006390)3.54931416
35positive regulation of chromosome segregation (GO:0051984)3.54332059
36DNA topological change (GO:0006265)3.54115947
37rRNA transcription (GO:0009303)3.51869233
38ribosomal large subunit biogenesis (GO:0042273)3.46170874
39heterochromatin organization (GO:0070828)3.42334901
40negative regulation of mRNA processing (GO:0050686)3.40467690
41rRNA modification (GO:0000154)3.39712237
42DNA replication checkpoint (GO:0000076)3.35171915
43rRNA processing (GO:0006364)3.35073905
44folic acid-containing compound biosynthetic process (GO:0009396)3.34706774
45chromosome condensation (GO:0030261)3.33760721
46negative regulation of mRNA metabolic process (GO:1903312)3.28128817
47DNA duplex unwinding (GO:0032508)3.26095786
48negative regulation of RNA splicing (GO:0033119)3.24502474
49establishment of chromosome localization (GO:0051303)3.24429941
50regulation of RNA export from nucleus (GO:0046831)3.23242741
51IMP biosynthetic process (GO:0006188)3.21730507
52rRNA methylation (GO:0031167)3.21555273
53regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.20211263
54rRNA metabolic process (GO:0016072)3.20127032
55viral mRNA export from host cell nucleus (GO:0046784)3.19854657
56telomere maintenance via recombination (GO:0000722)3.17173424
57tRNA methylation (GO:0030488)3.14426643
58establishment of viral latency (GO:0019043)3.12980280
59DNA geometric change (GO:0032392)3.10340902
60regulation of mammary gland epithelial cell proliferation (GO:0033599)3.07392258
61DNA conformation change (GO:0071103)3.05970527
62mRNA splicing, via spliceosome (GO:0000398)3.03481191
63RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.03481191
64spliceosomal snRNP assembly (GO:0000387)3.03422745
65mitotic recombination (GO:0006312)3.00153667
66pseudouridine synthesis (GO:0001522)3.00005062
67RNA splicing, via transesterification reactions (GO:0000375)2.98713167
68termination of RNA polymerase II transcription (GO:0006369)2.97121171
69regulation of chromosome segregation (GO:0051983)2.95934093
70mitochondrial RNA metabolic process (GO:0000959)2.95439620
71peptidyl-arginine omega-N-methylation (GO:0035247)2.94646442
72DNA packaging (GO:0006323)2.94552497
73nuclear envelope organization (GO:0006998)2.93808066
74IMP metabolic process (GO:0046040)2.89786448
75DNA synthesis involved in DNA repair (GO:0000731)2.89165726
76maturation of 5.8S rRNA (GO:0000460)2.88592363
77regulation of sister chromatid cohesion (GO:0007063)2.85753706
78proline biosynthetic process (GO:0006561)2.83494566
79positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.83142765
80positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.83142765
81positive regulation of mitotic sister chromatid separation (GO:1901970)2.83142765
82nucleobase-containing small molecule interconversion (GO:0015949)2.81548066
83regulation of mitotic spindle organization (GO:0060236)2.80735193
84nucleobase biosynthetic process (GO:0046112)2.80306598
85regulation of nucleobase-containing compound transport (GO:0032239)2.80023788
86ribosomal small subunit assembly (GO:0000028)2.79545175
87regulation of mitochondrial translation (GO:0070129)2.78575276
88protein localization to chromosome (GO:0034502)2.78139975
89regulation of spindle organization (GO:0090224)2.76301506
90tRNA aminoacylation for protein translation (GO:0006418)2.76290356
91mitochondrial DNA metabolic process (GO:0032042)2.73859005
92chromatin assembly (GO:0031497)2.71318815
93tRNA aminoacylation (GO:0043039)2.71068638
94amino acid activation (GO:0043038)2.71068638
95negative regulation of chromosome segregation (GO:0051985)2.70900699
96positive regulation of DNA-templated transcription, elongation (GO:0032786)2.70701621
97mRNA transport (GO:0051028)2.70407620
98chromosome segregation (GO:0007059)2.69473888
99telomere maintenance via telomere lengthening (GO:0010833)2.69431607
100regulation of chromatin binding (GO:0035561)2.69055994

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.52943602
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.20271551
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.15783893
4HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.58423304
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.58415743
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.09091841
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.89139222
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.77165039
9MYC_19030024_ChIP-ChIP_MESCs_Mouse2.76591333
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.73055105
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.71896671
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.69173275
13MYC_22102868_ChIP-Seq_BL_Human2.58496480
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.52616232
15XRN2_22483619_ChIP-Seq_HELA_Human2.41830692
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.32860485
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.29549375
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.19021880
19THAP11_20581084_ChIP-Seq_MESCs_Mouse2.18548110
20DCP1A_22483619_ChIP-Seq_HELA_Human2.09046351
21POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.06876403
22MYCN_18555785_ChIP-Seq_MESCs_Mouse1.95234111
23EST1_17652178_ChIP-ChIP_JURKAT_Human1.93449094
24TTF2_22483619_ChIP-Seq_HELA_Human1.93117973
25ZFX_18555785_ChIP-Seq_MESCs_Mouse1.93008771
26AR_21909140_ChIP-Seq_LNCAP_Human1.91647788
27E2F1_21310950_ChIP-Seq_MCF-7_Human1.89795019
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.86392060
29GABP_17652178_ChIP-ChIP_JURKAT_Human1.81304261
30EGR1_19374776_ChIP-ChIP_THP-1_Human1.81099608
31GABP_19822575_ChIP-Seq_HepG2_Human1.78715117
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.77527536
33DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.77076982
34CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.74610619
35E2F1_18555785_ChIP-Seq_MESCs_Mouse1.72660852
36KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.70512518
37CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.69071875
38KDM5A_27292631_Chip-Seq_BREAST_Human1.67966519
39YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63386917
40ZNF263_19887448_ChIP-Seq_K562_Human1.62408810
41FOXP3_21729870_ChIP-Seq_TREG_Human1.57644154
42ELF1_17652178_ChIP-ChIP_JURKAT_Human1.54558663
43TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.52485618
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.50530981
45KLF4_18555785_ChIP-Seq_MESCs_Mouse1.49536415
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.47096766
47CIITA_25753668_ChIP-Seq_RAJI_Human1.45108205
48NANOG_18555785_ChIP-Seq_MESCs_Mouse1.45036059
49TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44178173
50CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.43978027
51* VDR_21846776_ChIP-Seq_THP-1_Human1.41849388
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41763165
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.40978357
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.40221334
55* NOTCH1_21737748_ChIP-Seq_TLL_Human1.39604692
56ERG_20887958_ChIP-Seq_HPC-7_Mouse1.34496940
57VDR_23849224_ChIP-Seq_CD4+_Human1.33181895
58CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.32243674
59FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.32082340
60NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.31566353
61* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.30675918
62ESR1_15608294_ChIP-ChIP_MCF-7_Human1.27300910
63ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.24467803
64ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.21150301
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.20469577
66CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.19222629
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18242478
68PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.17813752
69STAT3_1855785_ChIP-Seq_MESCs_Mouse1.17624859
70BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.15754844
71HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.15718674
72TFEB_21752829_ChIP-Seq_HELA_Human1.14824291
73TP63_17297297_ChIP-ChIP_HaCaT_Human1.10002362
74PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07826051
75TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.05638605
76CHD1_26751641_Chip-Seq_LNCaP_Human1.04827819
77GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00080776
78FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99769387
79KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.99116837
80SRF_21415370_ChIP-Seq_HL-1_Mouse0.98891451
81TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98016531
82KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97691152
83ELK1_19687146_ChIP-ChIP_HELA_Human0.96976224
84ELK3_25401928_ChIP-Seq_HUVEC_Human0.96370811
85KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.95910270
86KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.95824076
87E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.95272566
88POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.94101474
89PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.94008269
90SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.92689276
91RACK7_27058665_Chip-Seq_MCF-7_Human0.91503254
92ATF3_27146783_Chip-Seq_COLON_Human0.91294888
93SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.90114036
94MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.89900577
95SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.89650756
96PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.85532259
97DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.85526709
98CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.83656013
99TET1_21451524_ChIP-Seq_MESCs_Mouse0.82804159
100POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.82266762

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.86409488
2MP0003111_abnormal_nucleus_morphology4.62139775
3MP0010094_abnormal_chromosome_stability4.30202741
4MP0004957_abnormal_blastocyst_morpholog4.10916234
5MP0003077_abnormal_cell_cycle3.55982481
6MP0008057_abnormal_DNA_replication3.47842864
7MP0008058_abnormal_DNA_repair3.06988799
8MP0008932_abnormal_embryonic_tissue2.74072620
9MP0001730_embryonic_growth_arrest2.65152453
10MP0000350_abnormal_cell_proliferation2.32382100
11MP0008007_abnormal_cellular_replicative2.22081578
12MP0005451_abnormal_body_composition2.20436319
13MP0002396_abnormal_hematopoietic_system2.07786613
14MP0004185_abnormal_adipocyte_glucose2.02961978
15MP0002877_abnormal_melanocyte_morpholog1.96088459
16MP0004233_abnormal_muscle_weight1.93438323
17MP0000537_abnormal_urethra_morphology1.93322003
18MP0005380_embryogenesis_phenotype1.89536984
19MP0001672_abnormal_embryogenesis/_devel1.89536984
20MP0002080_prenatal_lethality1.81935828
21MP0001697_abnormal_embryo_size1.81134296
22MP0003984_embryonic_growth_retardation1.76040966
23MP0010352_gastrointestinal_tract_polyps1.74479178
24MP0005076_abnormal_cell_differentiation1.73720704
25MP0010234_abnormal_vibrissa_follicle1.73138295
26MP0003786_premature_aging1.68225805
27MP0002088_abnormal_embryonic_growth/wei1.66414190
28MP0000313_abnormal_cell_death1.59227460
29MP0009697_abnormal_copulation1.55855249
30MP0002085_abnormal_embryonic_tissue1.54577598
31MP0009672_abnormal_birth_weight1.53308750
32MP0004808_abnormal_hematopoietic_stem1.52514956
33MP0006035_abnormal_mitochondrial_morpho1.48184742
34MP0005501_abnormal_skin_physiology1.43501989
35MP0002086_abnormal_extraembryonic_tissu1.43414894
36MP0003315_abnormal_perineum_morphology1.42238818
37MP0010307_abnormal_tumor_latency1.41573224
38MP0002796_impaired_skin_barrier1.41082112
39MP0002084_abnormal_developmental_patter1.41036685
40MP0009053_abnormal_anal_canal1.35079196
41MP0001346_abnormal_lacrimal_gland1.34246661
42MP0000490_abnormal_crypts_of1.32782413
43MP0009333_abnormal_splenocyte_physiolog1.32427307
44MP0003718_maternal_effect1.30143064
45MP0001661_extended_life_span1.28056526
46MP0004197_abnormal_fetal_growth/weight/1.26237446
47MP0005623_abnormal_meninges_morphology1.22734868
48MP0003705_abnormal_hypodermis_morpholog1.22455620
49MP0002009_preneoplasia1.22389751
50MP0002019_abnormal_tumor_incidence1.17585991
51MP0000358_abnormal_cell_content/1.12150038
52MP0003221_abnormal_cardiomyocyte_apopto1.09802619
53MP0004264_abnormal_extraembryonic_tissu1.07674476
54MP0008260_abnormal_autophagy1.03278883
55MP0000678_abnormal_parathyroid_gland1.00054959
56MP0003763_abnormal_thymus_physiology0.98135892
57MP0005621_abnormal_cell_physiology0.96993044
58MP0000703_abnormal_thymus_morphology0.95315502
59MP0005384_cellular_phenotype0.94725079
60MP0001727_abnormal_embryo_implantation0.93537464
61MP0006292_abnormal_olfactory_placode0.92224321
62MP0002697_abnormal_eye_size0.90179038
63MP0010030_abnormal_orbit_morphology0.89465597
64MP0006036_abnormal_mitochondrial_physio0.88430785
65MP0003566_abnormal_cell_adhesion0.86094742
66MP0000579_abnormal_nail_morphology0.85563385
67MP0003941_abnormal_skin_development0.82367290
68MP0002210_abnormal_sex_determination0.82301677
69MP0002089_abnormal_postnatal_growth/wei0.80097519
70MP0003453_abnormal_keratinocyte_physiol0.80036352
71MP0002160_abnormal_reproductive_system0.78988263
72MP0000627_abnormal_mammary_gland0.78957095
73MP0001881_abnormal_mammary_gland0.78350050
74MP0001293_anophthalmia0.78330407
75MP0002111_abnormal_tail_morphology0.77034272
76MP0001849_ear_inflammation0.77009559
77MP0003123_paternal_imprinting0.76527637
78MP0000467_abnormal_esophagus_morphology0.75380465
79MP0001216_abnormal_epidermal_layer0.75373003
80MP0002006_tumorigenesis0.75236702
81MP0002092_abnormal_eye_morphology0.74055579
82MP0003943_abnormal_hepatobiliary_system0.73774147
83MP0002166_altered_tumor_susceptibility0.72255257
84MP0001929_abnormal_gametogenesis0.71715366
85MP0009703_decreased_birth_body0.71184206
86MP0002398_abnormal_bone_marrow0.70483388
87MP0003937_abnormal_limbs/digits/tail_de0.70223319
88MP0002060_abnormal_skin_morphology0.69832132
89MP0001915_intracranial_hemorrhage0.69780559
90MP0001145_abnormal_male_reproductive0.69349537
91MP0003942_abnormal_urinary_system0.69170409
92MP0002098_abnormal_vibrissa_morphology0.68879700
93MP0003890_abnormal_embryonic-extraembry0.67234588
94MP0001286_abnormal_eye_development0.66987701
95MP0003115_abnormal_respiratory_system0.66833628
96MP0002249_abnormal_larynx_morphology0.66779648
97MP0000477_abnormal_intestine_morphology0.66649917
98MP0001348_abnormal_lacrimal_gland0.64576537
99MP0000428_abnormal_craniofacial_morphol0.64545339
100MP0000733_abnormal_muscle_development0.63769922

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.12276486
2Microvesicular hepatic steatosis (HP:0001414)3.96837226
3Chromsome breakage (HP:0040012)3.93717975
4Trismus (HP:0000211)3.58978273
5Multiple enchondromatosis (HP:0005701)3.56955320
6* Progressive muscle weakness (HP:0003323)3.30989957
7Proximal placement of thumb (HP:0009623)3.09157220
8Deviation of the thumb (HP:0009603)3.04306666
9Selective tooth agenesis (HP:0001592)2.97570545
10Septate vagina (HP:0001153)2.94880298
11Birth length less than 3rd percentile (HP:0003561)2.83344649
12Reticulocytopenia (HP:0001896)2.81024698
13Abnormality of cells of the erythroid lineage (HP:0012130)2.76628965
14Increased nuchal translucency (HP:0010880)2.75789279
15Hyperacusis (HP:0010780)2.71307455
16Abnormality of the preputium (HP:0100587)2.67053699
17Aplasia/Hypoplasia of the sacrum (HP:0008517)2.66748908
18Squamous cell carcinoma (HP:0002860)2.62147987
19Urethral obstruction (HP:0000796)2.58964624
20Abnormal number of erythroid precursors (HP:0012131)2.43624156
21Aplastic anemia (HP:0001915)2.37346290
22Rough bone trabeculation (HP:0100670)2.36188158
23Abnormal number of incisors (HP:0011064)2.35866616
24Abnormality of the umbilical cord (HP:0010881)2.31092615
25Insomnia (HP:0100785)2.30587597
26Nephroblastoma (Wilms tumor) (HP:0002667)2.30147109
27Facial cleft (HP:0002006)2.22043901
28Cleft eyelid (HP:0000625)2.21687957
29Abnormality of the fetal cardiovascular system (HP:0010948)2.21022423
30Abnormal umbilical cord blood vessels (HP:0011403)2.21022423
31Single umbilical artery (HP:0001195)2.21022423
32* Progressive external ophthalmoplegia (HP:0000590)2.20821068
33Myelodysplasia (HP:0002863)2.16688452
34Sparse lateral eyebrow (HP:0005338)2.16446921
35High anterior hairline (HP:0009890)2.12183306
36Abnormality of the phalanges of the hallux (HP:0010057)2.11905881
37Poikiloderma (HP:0001029)2.09185556
38Abnormality of the distal phalanges of the toes (HP:0010182)2.08778194
39Embryonal renal neoplasm (HP:0011794)2.07650480
40Overlapping toe (HP:0001845)2.07529886
41Atresia of the external auditory canal (HP:0000413)2.06091518
42Broad distal phalanx of finger (HP:0009836)2.04349959
43Overriding aorta (HP:0002623)2.02299848
44Abnormality of glycolysis (HP:0004366)1.98683392
45Meckel diverticulum (HP:0002245)1.98149888
4611 pairs of ribs (HP:0000878)1.97834989
47Abnormality of chromosome stability (HP:0003220)1.92914641
48Short thumb (HP:0009778)1.92542666
49Abnormalities of placenta or umbilical cord (HP:0001194)1.92514093
50Abnormal lung lobation (HP:0002101)1.92502630
51* Ragged-red muscle fibers (HP:0003200)1.92487572
52Horseshoe kidney (HP:0000085)1.91813342
53Shoulder girdle muscle weakness (HP:0003547)1.91072210
54Glossoptosis (HP:0000162)1.90543881
55* Premature ovarian failure (HP:0008209)1.88179687
56Abnormal trabecular bone morphology (HP:0100671)1.87231907
57Choanal atresia (HP:0000453)1.86422618
58Achilles tendon contracture (HP:0001771)1.85785243
59Secondary amenorrhea (HP:0000869)1.85607981
60Macrocytic anemia (HP:0001972)1.83531962
61Abnormality of the ileum (HP:0001549)1.83463099
62Prominent nose (HP:0000448)1.80672384
63Preauricular skin tag (HP:0000384)1.79332601
64Abnormality of the distal phalanx of the thumb (HP:0009617)1.78699733
65Breast hypoplasia (HP:0003187)1.78680951
66Testicular atrophy (HP:0000029)1.78083577
67Microretrognathia (HP:0000308)1.76046331
68Increased serum pyruvate (HP:0003542)1.75971699
69Entropion (HP:0000621)1.75310106
70Absent radius (HP:0003974)1.72898895
71Missing ribs (HP:0000921)1.72813720
72Pancytopenia (HP:0001876)1.72259146
73Microglossia (HP:0000171)1.69798265
74Cafe-au-lait spot (HP:0000957)1.69042992
75Long palpebral fissure (HP:0000637)1.68420359
76Sparse eyelashes (HP:0000653)1.67815810
77Deep philtrum (HP:0002002)1.67611969
78Duodenal stenosis (HP:0100867)1.65451852
79Small intestinal stenosis (HP:0012848)1.65451852
80Self-mutilation (HP:0000742)1.65364049
81Aplasia/Hypoplasia of the uvula (HP:0010293)1.65333235
82Hypoplasia of the capital femoral epiphysis (HP:0003090)1.65140536
83Ureteral duplication (HP:0000073)1.65138502
84Absent thumb (HP:0009777)1.64993832
85Unilateral renal agenesis (HP:0000122)1.64603365
86Prominent metopic ridge (HP:0005487)1.64044470
87Centrally nucleated skeletal muscle fibers (HP:0003687)1.62271501
88Abnormality of reticulocytes (HP:0004312)1.62088212
89Asymmetry of the thorax (HP:0001555)1.61400691
90Abnormality of the Achilles tendon (HP:0005109)1.60795058
91Ulnar bowing (HP:0003031)1.60715796
92Elfin facies (HP:0004428)1.60600355
93Abnormality of the fingertips (HP:0001211)1.60262670
94Oral leukoplakia (HP:0002745)1.59893304
95Medulloblastoma (HP:0002885)1.59621403
96Abnormality of the carotid arteries (HP:0005344)1.59238529
97Ridged nail (HP:0001807)1.58771101
98Pallor (HP:0000980)1.57857391
99Abnormal ventriculo-arterial connection (HP:0011563)1.55411730
100Abnormal connection of the cardiac segments (HP:0011545)1.55411730

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.70036475
2CDC73.35636214
3NME23.34946647
4EEF2K3.30230934
5SMG13.29164933
6CDK123.05797131
7SRPK12.59930508
8TTK2.54157916
9SCYL22.20159520
10TSSK62.17208468
11VRK22.09998070
12MAP3K102.06997711
13IRAK32.02261087
14TRIB32.01005720
15EIF2AK11.94155353
16NEK11.92769125
17MST41.90559932
18PBK1.88954863
19DYRK31.85997323
20ICK1.81424089
21RPS6KB21.73702211
22BRD41.61244710
23EPHA21.61178740
24CDK71.47508342
25CHEK21.46191740
26PRPF4B1.45718589
27CHEK11.36615894
28CDK41.35722213
29MST1R1.34651534
30ATR1.33784547
31WEE11.31595968
32PLK11.29291161
33PLK41.28203471
34AURKB1.25668021
35MAP3K81.25290193
36PIM21.20681158
37STK101.19972159
38SIK11.17453178
39NEK21.13371966
40AURKA1.12364377
41LATS21.10970722
42PLK31.04645846
43PAK41.03753773
44CDK80.99609273
45MTOR0.97911508
46TAF10.97462563
47TESK20.97098941
48NME10.96001481
49PASK0.95297089
50EIF2AK30.93055143
51BRSK10.91903132
52MKNK10.90672852
53ALK0.90280155
54RPS6KA40.89590610
55TAOK20.85197173
56MAP3K140.84824838
57BRSK20.84015974
58PDK20.83785572
59STK160.83752105
60AKT20.82500930
61CDK20.73975558
62ZAK0.72469874
63MAPK110.66910533
64ATM0.66292649
65STK40.64990986
66CDK10.64520353
67EIF2AK20.63783446
68CDK60.60592818
69CDK90.60559937
70RAF10.59146721
71FGFR40.57221919
72MAP2K20.54268790
73PRKCI0.52487532
74CSNK2A20.52199130
75CAMK1D0.51563513
76BRAF0.51315415
77CLK10.50444670
78ERBB40.49386499
79CCNB10.49039640
80PIM10.44971054
81MAP3K90.42702002
82RPS6KA10.42567580
83MAPKAPK30.42498188
84ERN10.41008517
85VRK10.40785552
86CAMK1G0.39866564
87MKNK20.39222766
88CSNK2A10.37208875
89TTN0.36167054
90CSNK1E0.35926423
91MELK0.35884801
92RIPK10.35882870
93ARAF0.35741954
94PAK10.34399287
95MAPK140.33400334
96MET0.33040393
97MAP3K30.32947435
98PAK20.32371483
99LRRK20.31179389
100KDR0.30913490

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.57021964
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.01319816
3Spliceosome_Homo sapiens_hsa030403.28536234
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.24998840
5Mismatch repair_Homo sapiens_hsa034303.14338304
6Base excision repair_Homo sapiens_hsa034102.88048719
7RNA transport_Homo sapiens_hsa030132.87432539
8Non-homologous end-joining_Homo sapiens_hsa034502.76624700
9Cell cycle_Homo sapiens_hsa041102.62224169
10Ribosome_Homo sapiens_hsa030102.61559825
11RNA polymerase_Homo sapiens_hsa030202.54199601
12One carbon pool by folate_Homo sapiens_hsa006702.23029064
13Nucleotide excision repair_Homo sapiens_hsa034202.22910991
14mRNA surveillance pathway_Homo sapiens_hsa030152.18536577
15Proteasome_Homo sapiens_hsa030502.10567851
16Pyrimidine metabolism_Homo sapiens_hsa002402.03556689
17Homologous recombination_Homo sapiens_hsa034401.95493154
18Basal transcription factors_Homo sapiens_hsa030221.76001678
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.70845386
20Biosynthesis of amino acids_Homo sapiens_hsa012301.62394665
21Fanconi anemia pathway_Homo sapiens_hsa034601.52780791
22RNA degradation_Homo sapiens_hsa030181.48334599
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.34921299
24Selenocompound metabolism_Homo sapiens_hsa004501.33056487
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.32823896
26Pentose phosphate pathway_Homo sapiens_hsa000301.29328011
27Sulfur relay system_Homo sapiens_hsa041221.24175211
28Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.22387038
29Thyroid cancer_Homo sapiens_hsa052161.22250908
30p53 signaling pathway_Homo sapiens_hsa041151.15088118
31Epstein-Barr virus infection_Homo sapiens_hsa051691.12297218
32Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.11331496
33Carbon metabolism_Homo sapiens_hsa012001.08805156
34Central carbon metabolism in cancer_Homo sapiens_hsa052301.05674808
35Bladder cancer_Homo sapiens_hsa052191.01806637
36Chronic myeloid leukemia_Homo sapiens_hsa052201.01357916
37Purine metabolism_Homo sapiens_hsa002301.00147032
38Vitamin B6 metabolism_Homo sapiens_hsa007500.94596659
39Pyruvate metabolism_Homo sapiens_hsa006200.91626059
40Herpes simplex infection_Homo sapiens_hsa051680.89816932
41Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.89801185
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85196640
43Viral carcinogenesis_Homo sapiens_hsa052030.83657965
44Lysine degradation_Homo sapiens_hsa003100.81873741
45Small cell lung cancer_Homo sapiens_hsa052220.79190549
46Acute myeloid leukemia_Homo sapiens_hsa052210.78967877
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.78962421
48Oocyte meiosis_Homo sapiens_hsa041140.78640684
49N-Glycan biosynthesis_Homo sapiens_hsa005100.78525359
50HTLV-I infection_Homo sapiens_hsa051660.77850122
51MicroRNAs in cancer_Homo sapiens_hsa052060.77285881
52Folate biosynthesis_Homo sapiens_hsa007900.74054087
53Non-small cell lung cancer_Homo sapiens_hsa052230.71561322
54Prostate cancer_Homo sapiens_hsa052150.71293262
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71270189
56Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.71241171
57Fructose and mannose metabolism_Homo sapiens_hsa000510.68680603
58Apoptosis_Homo sapiens_hsa042100.66468224
59Pancreatic cancer_Homo sapiens_hsa052120.66333402
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.64593755
61Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.58583274
62Hepatitis B_Homo sapiens_hsa051610.55784195
63Galactose metabolism_Homo sapiens_hsa000520.54796187
64Colorectal cancer_Homo sapiens_hsa052100.54297791
65Adherens junction_Homo sapiens_hsa045200.51800705
66Steroid biosynthesis_Homo sapiens_hsa001000.50812617
67Shigellosis_Homo sapiens_hsa051310.49747402
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46182106
69Glutathione metabolism_Homo sapiens_hsa004800.45846323
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45668119
71Endometrial cancer_Homo sapiens_hsa052130.44232227
72Wnt signaling pathway_Homo sapiens_hsa043100.44120937
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43810555
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.41410962
75NF-kappa B signaling pathway_Homo sapiens_hsa040640.38814448
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38745470
77Measles_Homo sapiens_hsa051620.38358042
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32821797
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32278494
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.32144105
81Huntingtons disease_Homo sapiens_hsa050160.32083497
82Notch signaling pathway_Homo sapiens_hsa043300.32054676
83Hippo signaling pathway_Homo sapiens_hsa043900.32023604
84mTOR signaling pathway_Homo sapiens_hsa041500.30274466
85AMPK signaling pathway_Homo sapiens_hsa041520.30127145
86Basal cell carcinoma_Homo sapiens_hsa052170.30088227
87Insulin signaling pathway_Homo sapiens_hsa049100.29626633
88Fatty acid elongation_Homo sapiens_hsa000620.28784708
89TGF-beta signaling pathway_Homo sapiens_hsa043500.28003221
90RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.25967418
91B cell receptor signaling pathway_Homo sapiens_hsa046620.25539496
92ErbB signaling pathway_Homo sapiens_hsa040120.25112133
93Fatty acid biosynthesis_Homo sapiens_hsa000610.25071243
94Arginine and proline metabolism_Homo sapiens_hsa003300.23084336
95Influenza A_Homo sapiens_hsa051640.21072783
96Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.19610008
97Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.19470856
98Protein export_Homo sapiens_hsa030600.18808412
99Proteoglycans in cancer_Homo sapiens_hsa052050.18386012
100Glioma_Homo sapiens_hsa052140.17937310

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