ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pyrimidine nucleobase catabolic process (GO:0006208)	5.34402868
2	protein localization to synapse (GO:0035418)	4.58670689
3	nucleobase catabolic process (GO:0046113)	4.44145631
4	positive regulation of mitochondrial fission (GO:0090141)	3.98317906
5	behavioral response to nicotine (GO:0035095)	3.89964030
6	synaptic vesicle maturation (GO:0016188)	3.89146364
7	synaptic vesicle exocytosis (GO:0016079)	3.87462023
8	neuron cell-cell adhesion (GO:0007158)	3.72361758
9	establishment of mitochondrion localization (GO:0051654)	3.65177809
10	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	3.64290204
11	regulation of short-term neuronal synaptic plasticity (GO:0048172)	3.63960037
12	postsynaptic membrane organization (GO:0001941)	3.59706127
13	neurofilament cytoskeleton organization (GO:0060052)	3.56064362
14	glutamate secretion (GO:0014047)	3.43379813
15	vocalization behavior (GO:0071625)	3.38386058
16	axonal fasciculation (GO:0007413)	3.27827601
17	presynaptic membrane organization (GO:0097090)	3.22419956
18	gamma-aminobutyric acid transport (GO:0015812)	3.21929042
19	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.21097008
20	protein polyglutamylation (GO:0018095)	3.20194908
21	presynaptic membrane assembly (GO:0097105)	3.20082056
22	regulation of synaptic vesicle exocytosis (GO:2000300)	3.17980848
23	synapse assembly (GO:0007416)	3.09346590
24	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.06822746
25	neurotransmitter secretion (GO:0007269)	3.03336860
26	neuron recognition (GO:0008038)	3.01976287
27	neurotransmitter-gated ion channel clustering (GO:0072578)	3.00922324
28	dendritic spine morphogenesis (GO:0060997)	2.99321826
29	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.95468005
30	protein localization to cilium (GO:0061512)	2.93387682
31	DNA damage response, detection of DNA damage (GO:0042769)	2.92867953
32	negative regulation of microtubule polymerization (GO:0031115)	2.92230321
33	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.91429799
34	synaptic vesicle endocytosis (GO:0048488)	2.89437384
35	auditory behavior (GO:0031223)	2.87402317
36	exploration behavior (GO:0035640)	2.86253790
37	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.82563193
38	regulation of synaptic vesicle transport (GO:1902803)	2.82544949
39	transmission of nerve impulse (GO:0019226)	2.81709445
40	protein complex biogenesis (GO:0070271)	2.80391758
41	protein-cofactor linkage (GO:0018065)	2.78557034
42	neuronal ion channel clustering (GO:0045161)	2.78369224
43	regulation of synapse structural plasticity (GO:0051823)	2.76672045
44	neuronal action potential propagation (GO:0019227)	2.74784009
45	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	2.74459905
46	positive regulation of synapse assembly (GO:0051965)	2.72932395
47	synaptic transmission, glutamatergic (GO:0035249)	2.71691783
48	glycosphingolipid biosynthetic process (GO:0006688)	2.70553406
49	microtubule depolymerization (GO:0007019)	2.68282271
50	ribonucleoprotein complex disassembly (GO:0032988)	2.67441129
51	substrate-independent telencephalic tangential migration (GO:0021826)	2.66764574
52	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.66764574
53	ATP hydrolysis coupled proton transport (GO:0015991)	2.65805212
54	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	2.65805212
55	negative regulation of DNA recombination (GO:0045910)	2.65486721
56	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.64891014
57	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.64891014
58	NADH dehydrogenase complex assembly (GO:0010257)	2.64891014
59	nonmotile primary cilium assembly (GO:0035058)	2.63963904
60	regulation of mitochondrial fission (GO:0090140)	2.63466654
61	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	2.61107730
62	mitochondrion transport along microtubule (GO:0047497)	2.61107730
63	mitochondrial respiratory chain complex assembly (GO:0033108)	2.60434735
64	retinal ganglion cell axon guidance (GO:0031290)	2.59059275
65	cullin deneddylation (GO:0010388)	2.57419407
66	synaptic vesicle transport (GO:0048489)	2.57184773
67	establishment of synaptic vesicle localization (GO:0097480)	2.57184773
68	dendritic spine organization (GO:0097061)	2.56181294
69	neuron-neuron synaptic transmission (GO:0007270)	2.54869615
70	C4-dicarboxylate transport (GO:0015740)	2.53320250
71	cellular ketone body metabolic process (GO:0046950)	2.53223619
72	regulation of neurotransmitter levels (GO:0001505)	2.53199554
73	synaptic vesicle docking involved in exocytosis (GO:0016081)	2.52490839
74	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	2.52365830
75	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	2.52365830
76	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.52146634
77	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.51473408
78	ATP synthesis coupled proton transport (GO:0015986)	2.51473408
79	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.51218768
80	establishment of vesicle localization (GO:0051650)	2.50554219
81	neuromuscular synaptic transmission (GO:0007274)	2.49530367
82	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.49447481
83	protein insertion into membrane (GO:0051205)	2.48772101
84	short-term memory (GO:0007614)	2.47052332
85	acrosome reaction (GO:0007340)	2.46908620
86	establishment of melanosome localization (GO:0032401)	2.45918482
87	cell migration in hindbrain (GO:0021535)	2.45465015
88	neurotransmitter transport (GO:0006836)	2.44545075
89	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	2.44456554
90	positive regulation of dendritic spine morphogenesis (GO:0061003)	2.43821236
91	hippocampus development (GO:0021766)	2.43659153
92	sequestering of actin monomers (GO:0042989)	2.43464435
93	calcium ion-dependent exocytosis (GO:0017156)	2.42672150
94	peptidyl-cysteine modification (GO:0018198)	2.42540146
95	regulation of cilium movement (GO:0003352)	2.41318639
96	mechanosensory behavior (GO:0007638)	2.40434510
97	melanosome transport (GO:0032402)	2.38387992
98	microtubule polymerization or depolymerization (GO:0031109)	2.38353904
99	retinal cone cell development (GO:0046549)	2.38136288
100	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.37099374

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	5.16386614
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.92259993
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.96915195
4	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.82661146
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.67655691
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.42486476
7	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.36900172
8	REST_21632747_ChIP-Seq_MESCs_Mouse	2.35927749
9	REST_18959480_ChIP-ChIP_MESCs_Mouse	2.25286541
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.23652951
11	GBX2_23144817_ChIP-Seq_PC3_Human	2.23109226
12	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.18393434
13	TAF15_26573619_Chip-Seq_HEK293_Human	2.04093102
14	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.00320617
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.89039457
16	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.87609295
17	IGF1R_20145208_ChIP-Seq_DFB_Human	1.86258105
18	RNF2_27304074_Chip-Seq_NSC_Mouse	1.81407877
19	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.74169667
20	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.74092613
21	FUS_26573619_Chip-Seq_HEK293_Human	1.73280855
22	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.71192661
23	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.70196168
24	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.69515530
25	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.68582725
26	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.67001747
27	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.65264063
28	VDR_22108803_ChIP-Seq_LS180_Human	1.61276609
29	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.59593500
30	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.56799290
31	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.55438303
32	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.54776821
33	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.54341859
34	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.53888663
35	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.50454167
36	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.49576764
37	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.46948898
38	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.44794655
39	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.38132617
40	IRF1_19129219_ChIP-ChIP_H3396_Human	1.38017810
41	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.36850528
42	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.34216655
43	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.33344526
44	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.30707531
45	P300_19829295_ChIP-Seq_ESCs_Human	1.30229984
46	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.28790751
47	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.27865232
48	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.26460103
49	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.24584699
50	EWS_26573619_Chip-Seq_HEK293_Human	1.22261196
51	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.21402077
52	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.20160249
53	GABP_19822575_ChIP-Seq_HepG2_Human	1.19161353
54	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.14314093
55	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.12762460
56	TP53_22573176_ChIP-Seq_HFKS_Human	1.12180024
57	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.10283543
58	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.08080905
59	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.07868700
60	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.06309330
61	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.06245166
62	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.05813333
63	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	1.05549221
64	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.04523363
65	MYC_18940864_ChIP-ChIP_HL60_Human	1.03636969
66	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.03363498
67	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.02240996
68	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.01676725
69	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.00924274
70	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.99888698
71	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	0.99099024
72	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.99007772
73	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.98737091
74	CBP_20019798_ChIP-Seq_JUKART_Human	0.98737091
75	REST_19997604_ChIP-ChIP_NEURONS_Mouse	0.98410770
76	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.98028193
77	SMAD4_21799915_ChIP-Seq_A2780_Human	0.96547242
78	AR_25329375_ChIP-Seq_VCAP_Human	0.96163026
79	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.95686889
80	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.94380143
81	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.94380143
82	* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.93930579
83	ER_23166858_ChIP-Seq_MCF-7_Human	0.93196505
84	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.91742920
85	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.91328917
86	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.91328917
87	JUN_21703547_ChIP-Seq_K562_Human	0.90380464
88	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.90153351
89	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.89863318
90	XRN2_22483619_ChIP-Seq_HELA_Human	0.87222286
91	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.87018666
92	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.84612201
93	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.84440271
94	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.83208845
95	NCOR_22424771_ChIP-Seq_293T_Human	0.82725002
96	DCP1A_22483619_ChIP-Seq_HELA_Human	0.82640676
97	VDR_23849224_ChIP-Seq_CD4+_Human	0.82324044
98	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.79653071
99	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.79451602
100	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.78434460

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002822_catalepsy	3.65038999
2	MP0003880_abnormal_central_pattern	3.51735640
3	MP0003122_maternal_imprinting	3.27908636
4	MP0004859_abnormal_synaptic_plasticity	3.20894605
5	MP0001529_abnormal_vocalization	3.11099092
6	MP0004270_analgesia	2.81916797
7	MP0003787_abnormal_imprinting	2.67252165
8	MP0006276_abnormal_autonomic_nervous	2.48749083
9	MP0001984_abnormal_olfaction	2.37072191
10	MP0009046_muscle_twitch	2.34614290
11	MP0003635_abnormal_synaptic_transmissio	2.29488106
12	MP0003121_genomic_imprinting	2.27027600
13	MP0008877_abnormal_DNA_methylation	2.17708363
14	MP0001188_hyperpigmentation	2.14513527
15	MP0009745_abnormal_behavioral_response	2.10880554
16	MP0005423_abnormal_somatic_nervous	2.10604604
17	MP0002102_abnormal_ear_morphology	2.10184973
18	MP0005499_abnormal_olfactory_system	2.04105712
19	MP0005394_taste/olfaction_phenotype	2.04105712
20	MP0000778_abnormal_nervous_system	2.00789960
21	MP0002272_abnormal_nervous_system	1.98370597
22	MP0002734_abnormal_mechanical_nocicepti	1.96859776
23	MP0002736_abnormal_nociception_after	1.92217970
24	MP0002063_abnormal_learning/memory/cond	1.91921812
25	MP0001968_abnormal_touch/_nociception	1.91255694
26	MP0002064_seizures	1.85301311
27	MP0002572_abnormal_emotion/affect_behav	1.83420888
28	MP0001486_abnormal_startle_reflex	1.77958532
29	MP0008789_abnormal_olfactory_epithelium	1.67356787
30	MP0002557_abnormal_social/conspecific_i	1.60035999
31	MP0004142_abnormal_muscle_tone	1.59417110
32	MP0002735_abnormal_chemical_nociception	1.59242460
33	MP0006292_abnormal_olfactory_placode	1.56861960
34	MP0008995_early_reproductive_senescence	1.56718485
35	MP0004811_abnormal_neuron_physiology	1.54000296
36	MP0002184_abnormal_innervation	1.51030104
37	MP0000955_abnormal_spinal_cord	1.47998069
38	MP0001905_abnormal_dopamine_level	1.46234747
39	MP0002638_abnormal_pupillary_reflex	1.44001459
40	MP0002067_abnormal_sensory_capabilities	1.43272505
41	MP0005551_abnormal_eye_electrophysiolog	1.40493549
42	MP0002653_abnormal_ependyma_morphology	1.40466752
43	MP0001970_abnormal_pain_threshold	1.36230604
44	MP0004924_abnormal_behavior	1.34485335
45	MP0005386_behavior/neurological_phenoty	1.34485335
46	MP0005645_abnormal_hypothalamus_physiol	1.33856539
47	MP0004133_heterotaxia	1.33475395
48	MP0002882_abnormal_neuron_morphology	1.30685524
49	MP0003890_abnormal_embryonic-extraembry	1.21055567
50	MP0002733_abnormal_thermal_nociception	1.17593710
51	MP0005253_abnormal_eye_physiology	1.16903914
52	MP0002234_abnormal_pharynx_morphology	1.15722656
53	MP0005646_abnormal_pituitary_gland	1.13675750
54	MP0002909_abnormal_adrenal_gland	1.13387443
55	MP0002752_abnormal_somatic_nervous	1.12771878
56	MP0001502_abnormal_circadian_rhythm	1.10319709
57	MP0000631_abnormal_neuroendocrine_gland	1.10199366
58	MP0003123_paternal_imprinting	1.09682458
59	MP0005410_abnormal_fertilization	1.08173812
60	MP0001440_abnormal_grooming_behavior	1.08089420
61	MP0006072_abnormal_retinal_apoptosis	1.07496135
62	MP0002152_abnormal_brain_morphology	1.05291804
63	MP0002066_abnormal_motor_capabilities/c	1.05256820
64	MP0003011_delayed_dark_adaptation	1.04607553
65	MP0002751_abnormal_autonomic_nervous	1.02170149
66	MP0004742_abnormal_vestibular_system	1.00562285
67	MP0006035_abnormal_mitochondrial_morpho	0.98340603
68	MP0005187_abnormal_penis_morphology	0.96517235
69	MP0002069_abnormal_eating/drinking_beha	0.95551141
70	MP0002229_neurodegeneration	0.94950545
71	MP0000049_abnormal_middle_ear	0.92215165
72	MP0003861_abnormal_nervous_system	0.91751176
73	MP0004885_abnormal_endolymph	0.91552009
74	MP0003119_abnormal_digestive_system	0.91070849
75	MP0003698_abnormal_male_reproductive	0.90527567
76	MP0002160_abnormal_reproductive_system	0.88449953
77	MP0005084_abnormal_gallbladder_morpholo	0.86902725
78	MP0001485_abnormal_pinna_reflex	0.86585521
79	MP0000566_synostosis	0.84978354
80	MP0000026_abnormal_inner_ear	0.83849914
81	MP0000647_abnormal_sebaceous_gland	0.82595549
82	MP0002938_white_spotting	0.81445246
83	MP0001963_abnormal_hearing_physiology	0.79261547
84	MP0008058_abnormal_DNA_repair	0.79020858
85	MP0002090_abnormal_vision	0.78678465
86	MP0010386_abnormal_urinary_bladder	0.77113366
87	MP0003938_abnormal_ear_development	0.77058741
88	MP0001501_abnormal_sleep_pattern	0.76306403
89	MP0003718_maternal_effect	0.74896906
90	MP0001986_abnormal_taste_sensitivity	0.74844183
91	MP0003137_abnormal_impulse_conducting	0.73032787
92	MP0001929_abnormal_gametogenesis	0.72395378
93	MP0005248_abnormal_Harderian_gland	0.72081409
94	MP0002210_abnormal_sex_determination	0.70717206
95	MP0004147_increased_porphyrin_level	0.69784082
96	MP0003879_abnormal_hair_cell	0.69744177
97	MP0005195_abnormal_posterior_eye	0.68670942
98	MP0003329_amyloid_beta_deposits	0.67626724
99	MP0008569_lethality_at_weaning	0.67031121
100	MP0008872_abnormal_physiological_respon	0.66483218

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Myokymia (HP:0002411)	4.19716380
2	Polyphagia (HP:0002591)	3.76862807
3	Abnormality of the labia minora (HP:0012880)	3.27978569
4	Limb dystonia (HP:0002451)	3.25995189
5	Acute necrotizing encephalopathy (HP:0006965)	3.18899595
6	Gait imbalance (HP:0002141)	3.13465434
7	Cortical dysplasia (HP:0002539)	3.11662666
8	Abnormal mitochondria in muscle tissue (HP:0008316)	3.00800523
9	Acute encephalopathy (HP:0006846)	2.88357408
10	Medial flaring of the eyebrow (HP:0010747)	2.88013697
11	Epileptic encephalopathy (HP:0200134)	2.84473476
12	Nephrogenic diabetes insipidus (HP:0009806)	2.81766707
13	Congenital primary aphakia (HP:0007707)	2.78733770
14	Focal motor seizures (HP:0011153)	2.70906013
15	Failure to thrive in infancy (HP:0001531)	2.70120015
16	Poor suck (HP:0002033)	2.64402795
17	Focal seizures (HP:0007359)	2.62409591
18	Progressive macrocephaly (HP:0004481)	2.61315186
19	Mitochondrial inheritance (HP:0001427)	2.55421458
20	Lissencephaly (HP:0001339)	2.47931496
21	Specific learning disability (HP:0001328)	2.44312267
22	Cerebral hypomyelination (HP:0006808)	2.42970124
23	Retinal dysplasia (HP:0007973)	2.42011275
24	Aplasia/Hypoplasia of the brainstem (HP:0007362)	2.39000137
25	Hypoplasia of the brainstem (HP:0002365)	2.39000137
26	Drooling (HP:0002307)	2.38808842
27	Abnormal eating behavior (HP:0100738)	2.34894071
28	Increased CSF lactate (HP:0002490)	2.34810045
29	Impaired vibration sensation in the lower limbs (HP:0002166)	2.33231962
30	Atonic seizures (HP:0010819)	2.29895726
31	Progressive cerebellar ataxia (HP:0002073)	2.29799473
32	True hermaphroditism (HP:0010459)	2.28093501
33	Vaginal atresia (HP:0000148)	2.27898666
34	Genital tract atresia (HP:0001827)	2.27379040
35	Amblyopia (HP:0000646)	2.25741109
36	Hepatocellular necrosis (HP:0001404)	2.23692960
37	Pancreatic fibrosis (HP:0100732)	2.21970153
38	Hypsarrhythmia (HP:0002521)	2.19817866
39	Spastic tetraplegia (HP:0002510)	2.19694202
40	Amyotrophic lateral sclerosis (HP:0007354)	2.19036347
41	Hepatic necrosis (HP:0002605)	2.17170839
42	Epileptiform EEG discharges (HP:0011182)	2.15982696
43	EEG with generalized epileptiform discharges (HP:0011198)	2.13966534
44	Abnormality of the corticospinal tract (HP:0002492)	2.13920782
45	Excessive salivation (HP:0003781)	2.11423562
46	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.11046300
47	Abnormality of alanine metabolism (HP:0010916)	2.11046300
48	Hyperalaninemia (HP:0003348)	2.11046300
49	Febrile seizures (HP:0002373)	2.10785125
50	Pachygyria (HP:0001302)	2.10002879
51	Urinary urgency (HP:0000012)	2.09556223
52	Increased hepatocellular lipid droplets (HP:0006565)	2.08310508
53	3-Methylglutaconic aciduria (HP:0003535)	2.07982441
54	Inability to walk (HP:0002540)	2.06064489
55	Pancreatic cysts (HP:0001737)	2.05835947
56	Atrophy/Degeneration involving motor neurons (HP:0007373)	2.05293811
57	CNS hypomyelination (HP:0003429)	2.05066570
58	Broad-based gait (HP:0002136)	2.05012714
59	Nephronophthisis (HP:0000090)	2.03716624
60	Pendular nystagmus (HP:0012043)	2.03400155
61	Muscular hypotonia of the trunk (HP:0008936)	2.02207351
62	Abnormality of midbrain morphology (HP:0002418)	2.00824768
63	Molar tooth sign on MRI (HP:0002419)	2.00824768
64	Ankle clonus (HP:0011448)	2.00744068
65	Sleep apnea (HP:0010535)	2.00195187
66	Spastic gait (HP:0002064)	1.99015802
67	Hyperglycinemia (HP:0002154)	1.98525199
68	Poor coordination (HP:0002370)	1.97502367
69	Chronic hepatic failure (HP:0100626)	1.97057474
70	Cerebral edema (HP:0002181)	1.96667151
71	Lipid accumulation in hepatocytes (HP:0006561)	1.96240740
72	Labial hypoplasia (HP:0000066)	1.95743157
73	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.95523476
74	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.95523476
75	Dialeptic seizures (HP:0011146)	1.94716027
76	Oligodactyly (hands) (HP:0001180)	1.93578955
77	Sclerocornea (HP:0000647)	1.93479514
78	Occipital encephalocele (HP:0002085)	1.91974710
79	Status epilepticus (HP:0002133)	1.88796832
80	Progressive inability to walk (HP:0002505)	1.87430874
81	Action tremor (HP:0002345)	1.83792091
82	Morphological abnormality of the pyramidal tract (HP:0002062)	1.81879297
83	Generalized tonic-clonic seizures (HP:0002069)	1.81788070
84	Hypoplastic female external genitalia (HP:0012815)	1.80702023
85	Renal Fanconi syndrome (HP:0001994)	1.80433754
86	Hypothermia (HP:0002045)	1.79507996
87	Delusions (HP:0000746)	1.76855288
88	Esotropia (HP:0000565)	1.76683199
89	Agitation (HP:0000713)	1.75675729
90	Optic disc pallor (HP:0000543)	1.74018239
91	Abnormal hair whorl (HP:0010721)	1.73561253
92	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.71356993
93	Aplasia/hypoplasia of the uterus (HP:0008684)	1.70462677
94	Peripheral hypomyelination (HP:0007182)	1.69678408
95	Upper limb muscle weakness (HP:0003484)	1.69503907
96	Optic nerve hypoplasia (HP:0000609)	1.68944154
97	Increased serum lactate (HP:0002151)	1.68927823
98	Oligomenorrhea (HP:0000876)	1.68624206
99	Abnormality of glycolysis (HP:0004366)	1.68285303
100	Emotional lability (HP:0000712)	1.68229463

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MARK1	3.80432716
2	TRIM28	3.45607487
3	BCR	3.26144379
4	MAP4K2	3.03510978
5	CASK	2.96590720
6	MAP2K7	2.81190276
7	MAP3K4	2.64867456
8	DYRK3	2.29545735
9	DYRK2	2.26801119
10	MAPK13	2.12685428
11	WNK3	2.08991505
12	MINK1	2.08472394
13	CSNK1G2	2.06884201
14	PINK1	2.03281750
15	CSNK1G3	1.98334488
16	STK16	1.92757027
17	EPHA4	1.81936670
18	CSNK1A1L	1.77417188
19	NTRK2	1.61560554
20	ERBB3	1.60694649
21	CDK19	1.60409031
22	PLK2	1.57788233
23	NTRK3	1.57380472
24	CSNK1G1	1.56330490
25	MAP3K12	1.52957325
26	UHMK1	1.52340884
27	PAK3	1.42107429
28	TESK1	1.37494600
29	LIMK1	1.32632437
30	PRKCG	1.28508066
31	SIK3	1.28337384
32	BCKDK	1.28164908
33	MAP2K4	1.18405380
34	DYRK1B	1.18376164
35	TSSK6	1.15196365
36	SRPK1	1.13335030
37	DAPK2	1.12187321
38	BUB1	1.11861237
39	PAK6	1.08076364
40	RPS6KA4	1.03851551
41	PLK4	1.03138589
42	MAP3K9	0.96140864
43	SIK2	0.94296305
44	CDK14	0.92852948
45	CDK5	0.92122319
46	CAMK2B	0.88443202
47	BMPR1B	0.86795597
48	DYRK1A	0.85968975
49	WNK4	0.85884950
50	PHKG1	0.85399421
51	PHKG2	0.85399421
52	PRKD3	0.84393818
53	CAMK2A	0.79892022
54	KSR1	0.79479467
55	CDK18	0.78114664
56	PRKCE	0.78048157
57	GRK1	0.71415787
58	CDK15	0.66891381
59	CDK11A	0.66493898
60	NME1	0.64600107
61	PLK3	0.64504818
62	OXSR1	0.63397992
63	SGK494	0.63116399
64	SGK223	0.63116399
65	BRSK1	0.60139893
66	NEK1	0.59227212
67	PNCK	0.58781432
68	PLK1	0.58506187
69	CAMK2G	0.58002971
70	ARAF	0.57742139
71	EPHA3	0.57124254
72	PIM2	0.56873679
73	INSRR	0.56616711
74	TNIK	0.54203570
75	CAMK2D	0.53670910
76	PRKCZ	0.53091940
77	CAMKK2	0.51445029
78	CSNK1A1	0.51254811
79	CSNK1E	0.51075075
80	ZAK	0.50150591
81	CAMK4	0.49196483
82	DAPK1	0.47515980
83	AURKA	0.45502257
84	CCNB1	0.42229958
85	CAMK1	0.41768135
86	MAP3K11	0.41525517
87	EPHB2	0.41362994
88	GRK5	0.39677066
89	PRKACA	0.39530368
90	MST4	0.39332390
91	PRKCI	0.38682014
92	CSNK1D	0.38106407
93	PKN1	0.37967666
94	LMTK2	0.37224942
95	WEE1	0.35662015
96	PRKAA1	0.35027386
97	ADRBK2	0.34134656
98	MAPKAPK5	0.32587285
99	EIF2AK1	0.31409224
100	RPS6KA5	0.31409049

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.66702843
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.03878229
3	Synaptic vesicle cycle_Homo sapiens_hsa04721	2.87057882
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.67386722
5	Parkinsons disease_Homo sapiens_hsa05012	2.64752230
6	GABAergic synapse_Homo sapiens_hsa04727	2.35977825
7	Collecting duct acid secretion_Homo sapiens_hsa04966	1.99274339
8	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.97603037
9	Protein export_Homo sapiens_hsa03060	1.89002759
10	Proteasome_Homo sapiens_hsa03050	1.86589832
11	Morphine addiction_Homo sapiens_hsa05032	1.86282536
12	Huntingtons disease_Homo sapiens_hsa05016	1.83314706
13	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.77966423
14	Alzheimers disease_Homo sapiens_hsa05010	1.76291374
15	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.70627481
16	Phototransduction_Homo sapiens_hsa04744	1.66100507
17	Cardiac muscle contraction_Homo sapiens_hsa04260	1.61551437
18	Dopaminergic synapse_Homo sapiens_hsa04728	1.61042429
19	Butanoate metabolism_Homo sapiens_hsa00650	1.59877747
20	Glutamatergic synapse_Homo sapiens_hsa04724	1.57318966
21	Cocaine addiction_Homo sapiens_hsa05030	1.53368297
22	Steroid biosynthesis_Homo sapiens_hsa00100	1.45454826
23	Circadian entrainment_Homo sapiens_hsa04713	1.44539341
24	Vibrio cholerae infection_Homo sapiens_hsa05110	1.41515407
25	Taste transduction_Homo sapiens_hsa04742	1.39284131
26	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.39267196
27	Amphetamine addiction_Homo sapiens_hsa05031	1.37809720
28	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.34071556
29	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.30907426
30	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.24417613
31	RNA polymerase_Homo sapiens_hsa03020	1.23306594
32	Basal transcription factors_Homo sapiens_hsa03022	1.22657640
33	Fatty acid elongation_Homo sapiens_hsa00062	1.17663753
34	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.11922580
35	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.11698238
36	Regulation of autophagy_Homo sapiens_hsa04140	1.08870444
37	Olfactory transduction_Homo sapiens_hsa04740	1.05088171
38	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.03745944
39	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.03558782
40	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.03048863
41	Insulin secretion_Homo sapiens_hsa04911	1.02323992
42	Serotonergic synapse_Homo sapiens_hsa04726	1.02063393
43	Axon guidance_Homo sapiens_hsa04360	1.00534399
44	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.99906507
45	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.99003716
46	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.98240457
47	Oocyte meiosis_Homo sapiens_hsa04114	0.92061261
48	Arginine and proline metabolism_Homo sapiens_hsa00330	0.89586434
49	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.87676751
50	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.86534760
51	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.86174977
52	Propanoate metabolism_Homo sapiens_hsa00640	0.86168781
53	Cholinergic synapse_Homo sapiens_hsa04725	0.84003149
54	RNA degradation_Homo sapiens_hsa03018	0.83314686
55	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.83208911
56	Fanconi anemia pathway_Homo sapiens_hsa03460	0.81357016
57	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.79287091
58	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.75889744
59	Mismatch repair_Homo sapiens_hsa03430	0.75594569
60	Sulfur relay system_Homo sapiens_hsa04122	0.74076967
61	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.71302369
62	Peroxisome_Homo sapiens_hsa04146	0.71004571
63	Base excision repair_Homo sapiens_hsa03410	0.69113826
64	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.69106196
65	Pyruvate metabolism_Homo sapiens_hsa00620	0.68804647
66	RNA transport_Homo sapiens_hsa03013	0.67797437
67	Spliceosome_Homo sapiens_hsa03040	0.67046477
68	Gap junction_Homo sapiens_hsa04540	0.66418830
69	Long-term depression_Homo sapiens_hsa04730	0.65058444
70	Folate biosynthesis_Homo sapiens_hsa00790	0.63883234
71	Metabolic pathways_Homo sapiens_hsa01100	0.63073678
72	Phenylalanine metabolism_Homo sapiens_hsa00360	0.62153953
73	Selenocompound metabolism_Homo sapiens_hsa00450	0.60686415
74	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.60251207
75	Alcoholism_Homo sapiens_hsa05034	0.59810986
76	mRNA surveillance pathway_Homo sapiens_hsa03015	0.56612920
77	Pyrimidine metabolism_Homo sapiens_hsa00240	0.56509170
78	beta-Alanine metabolism_Homo sapiens_hsa00410	0.56284263
79	Carbon metabolism_Homo sapiens_hsa01200	0.55606231
80	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.54795743
81	Hippo signaling pathway_Homo sapiens_hsa04390	0.54683805
82	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.50339589
83	Arginine biosynthesis_Homo sapiens_hsa00220	0.48653187
84	Circadian rhythm_Homo sapiens_hsa04710	0.48600091
85	Purine metabolism_Homo sapiens_hsa00230	0.48562349
86	Fatty acid metabolism_Homo sapiens_hsa01212	0.48473168
87	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.45991576
88	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.44921935
89	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.43044066
90	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.41812369
91	Ether lipid metabolism_Homo sapiens_hsa00565	0.41735476
92	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.38410720
93	Long-term potentiation_Homo sapiens_hsa04720	0.38234588
94	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.38206195
95	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.37101946
96	Homologous recombination_Homo sapiens_hsa03440	0.36465896
97	Tight junction_Homo sapiens_hsa04530	0.36100576
98	Gastric acid secretion_Homo sapiens_hsa04971	0.36072381
99	Wnt signaling pathway_Homo sapiens_hsa04310	0.34279575
100	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.34029297

C10ORF35

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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