C10ORF54

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.54559796
2negative regulation of cell killing (GO:0031342)6.54172195
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.54172195
4positive regulation of gamma-delta T cell activation (GO:0046645)5.84632625
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.83878609
6antigen processing and presentation of endogenous antigen (GO:0019883)5.82410329
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.74078654
8positive regulation by organism of defense response of other organism involved in symbiotic interact5.74078654
9modulation by symbiont of host immune response (GO:0052553)5.74078654
10positive regulation by symbiont of host defense response (GO:0052509)5.74078654
11modulation by symbiont of host defense response (GO:0052031)5.74078654
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.74078654
13neutrophil activation involved in immune response (GO:0002283)5.67324793
14detection of other organism (GO:0098543)5.33519956
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.26282857
16detection of bacterium (GO:0016045)5.17805022
17response to peptidoglycan (GO:0032494)4.90054669
18macrophage activation involved in immune response (GO:0002281)4.81711854
19regulation of B cell receptor signaling pathway (GO:0050855)4.77307948
20leukocyte aggregation (GO:0070486)4.64259807
21detection of external biotic stimulus (GO:0098581)4.43781852
22cellular extravasation (GO:0045123)4.43010637
23neutrophil activation (GO:0042119)4.35671389
24negative regulation of interleukin-12 production (GO:0032695)4.30808173
25positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.21890569
26leukocyte migration involved in inflammatory response (GO:0002523)4.21268565
27regulation of gamma-delta T cell activation (GO:0046643)4.20732597
28respiratory burst (GO:0045730)4.15004444
29detection of molecule of bacterial origin (GO:0032490)4.07789435
30response to interleukin-15 (GO:0070672)4.06226644
31immunoglobulin mediated immune response (GO:0016064)4.00400081
32response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.96809310
33response to host immune response (GO:0052572)3.96809310
34granulocyte activation (GO:0036230)3.93872255
35regulation of interferon-beta biosynthetic process (GO:0045357)3.93569795
36* negative regulation of lymphocyte mediated immunity (GO:0002707)3.93191743
37regulation of mast cell degranulation (GO:0043304)3.91442489
38detection of biotic stimulus (GO:0009595)3.90832870
39microglial cell activation (GO:0001774)3.83300762
40myeloid cell activation involved in immune response (GO:0002275)3.75642016
41positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.75500711
42regulation of gamma-delta T cell differentiation (GO:0045586)3.71197286
43cellular response to interleukin-15 (GO:0071350)3.70307588
44response to host (GO:0075136)3.69968296
45response to host defenses (GO:0052200)3.69968296
46response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.69968296
47regulation of myeloid leukocyte mediated immunity (GO:0002886)3.67953464
48antigen processing and presentation via MHC class Ib (GO:0002475)3.61959852
49regulation of mast cell activation involved in immune response (GO:0033006)3.60168194
50macrophage activation (GO:0042116)3.58425171
51positive regulation of mast cell activation (GO:0033005)3.57878373
52* negative regulation of leukocyte mediated immunity (GO:0002704)3.57367510
53neutrophil mediated immunity (GO:0002446)3.56880157
54negative regulation of erythrocyte differentiation (GO:0045647)3.53049844
55regulation of leukocyte degranulation (GO:0043300)3.51169010
56regulation of T cell tolerance induction (GO:0002664)3.48412295
57response to muramyl dipeptide (GO:0032495)3.41711029
58regulation of tolerance induction (GO:0002643)3.41705957
59negative regulation of phagocytosis (GO:0050765)3.40010080
60B cell receptor signaling pathway (GO:0050853)3.35678855
61regulation of mast cell activation (GO:0033003)3.35670200
62regulation of B cell differentiation (GO:0045577)3.35167035
63type I interferon signaling pathway (GO:0060337)3.35049038
64cellular response to type I interferon (GO:0071357)3.35049038
65leukocyte degranulation (GO:0043299)3.34063758
66response to type I interferon (GO:0034340)3.32817689
67positive regulation of B cell differentiation (GO:0045579)3.32302648
68production of molecular mediator involved in inflammatory response (GO:0002532)3.24452126
69germinal center formation (GO:0002467)3.19568443
70negative thymic T cell selection (GO:0045060)3.19433816
71positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.18127347
72regulation of dendritic cell antigen processing and presentation (GO:0002604)3.16911295
73defense response to protozoan (GO:0042832)3.16165534
74B cell mediated immunity (GO:0019724)3.13256379
75positive thymic T cell selection (GO:0045059)3.13073899
76regulation of T-helper 2 cell differentiation (GO:0045628)3.12650167
77negative T cell selection (GO:0043383)3.10797368
78positive regulation of mast cell activation involved in immune response (GO:0033008)3.10163171
79positive regulation of mast cell degranulation (GO:0043306)3.10163171
80regulation of T cell mediated cytotoxicity (GO:0001914)3.07976626
81interferon-gamma-mediated signaling pathway (GO:0060333)3.07326201
82regulation of regulated secretory pathway (GO:1903305)3.07059653
83negative regulation of T-helper cell differentiation (GO:0045623)3.06217652
84negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.06217652
85negative regulation of interleukin-6 production (GO:0032715)3.05736169
86myeloid leukocyte mediated immunity (GO:0002444)3.05141663
87regulation of natural killer cell mediated immunity (GO:0002715)3.01979905
88regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.01979905
89negative regulation of innate immune response (GO:0045824)3.01601873
90positive regulation of T cell mediated cytotoxicity (GO:0001916)3.01576743
91negative regulation of type 2 immune response (GO:0002829)3.01373205
92negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.96619977
93tolerance induction (GO:0002507)2.94861657
94activated T cell proliferation (GO:0050798)2.92298023
95dendritic cell migration (GO:0036336)2.89107330
96positive regulation of tolerance induction (GO:0002645)2.87958977
97dendritic cell chemotaxis (GO:0002407)2.84563701
98lipopolysaccharide-mediated signaling pathway (GO:0031663)2.84480688
99myeloid leukocyte activation (GO:0002274)2.84419428
100T cell selection (GO:0045058)2.84046897

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.21217341
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.64138802
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.85679261
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.67088983
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.65595770
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.17894682
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.12807080
8IRF8_27001747_Chip-Seq_BMDM_Mouse2.97648946
9* VDR_21846776_ChIP-Seq_THP-1_Human2.90396317
10* VDR_24763502_ChIP-Seq_THP-1_Human2.75304333
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.73057676
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.68703279
13* SPI1_23547873_ChIP-Seq_NB4_Human2.66003065
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.65509760
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.61410427
16RUNX_20019798_ChIP-Seq_JUKART_Human2.60058549
17* SPI1_23127762_ChIP-Seq_K562_Human2.53562005
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.51711661
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.40409076
20* MAF_26560356_Chip-Seq_TH1_Human2.40291206
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.39587554
22SCL_19346495_ChIP-Seq_HPC-7_Human2.33303897
23RUNX1_22412390_ChIP-Seq_EML_Mouse2.32241763
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.28083237
25MYB_26560356_Chip-Seq_TH2_Human2.23316555
26UTX_26944678_Chip-Seq_JUKART_Human2.21134854
27* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.20563071
28MYC_22102868_ChIP-Seq_BL_Human2.17682728
29VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.16403380
30BRD4_27068464_Chip-Seq_AML-cells_Mouse2.14143941
31STAT4_19710469_ChIP-ChIP_TH1__Mouse2.13205722
32FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.12101569
33* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.04771626
34TCF7_22412390_ChIP-Seq_EML_Mouse2.04174919
35MYB_26560356_Chip-Seq_TH1_Human1.94170129
36EGR1_19374776_ChIP-ChIP_THP-1_Human1.93026381
37MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.91556101
38KDM2B_26808549_Chip-Seq_DND41_Human1.83075457
39MAF_26560356_Chip-Seq_TH2_Human1.80926166
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.78754642
41KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.76161593
42Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.75690180
43LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.70070529
44RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.69630137
45NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.67387364
46VDR_24787735_ChIP-Seq_THP-1_Human1.66995374
47CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.58982464
48LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.58630417
49GATA1_19941827_ChIP-Seq_MEL_Mouse1.58313159
50* GATA3_27048872_Chip-Seq_THYMUS_Human1.58119024
51ELK3_25401928_ChIP-Seq_HUVEC_Human1.56035269
52KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.54161981
53TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.53639739
54LXR_22292898_ChIP-Seq_THP-1_Human1.47853623
55SMAD_19615063_ChIP-ChIP_OVARY_Human1.47776161
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.46097555
57SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.42900091
58PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.39353465
59CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.38592183
60GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.38321361
61CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.38062187
62GATA2_22383799_ChIP-Seq_G1ME_Mouse1.37200761
63GATA1_22383799_ChIP-Seq_G1ME_Mouse1.32325074
64PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.31896037
65IKZF1_21737484_ChIP-ChIP_HCT116_Human1.29294236
66CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.27645529
67GATA1_19941826_ChIP-Seq_K562_Human1.26481514
68KDM2B_26808549_Chip-Seq_JURKAT_Human1.23965188
69SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23489002
70GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22877724
71PU_27001747_Chip-Seq_BMDM_Mouse1.22782439
72CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19709140
73SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19308647
74PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18883623
75GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17875155
76BCL6_27268052_Chip-Seq_Bcells_Human1.17595086
77STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17282042
78TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16589005
79* GATA3_26560356_Chip-Seq_TH2_Human1.16001184
80PU.1_20513432_ChIP-Seq_Bcells_Mouse1.15268017
81STAT6_21828071_ChIP-Seq_BEAS2B_Human1.15145211
82ELF1_17652178_ChIP-ChIP_JURKAT_Human1.14654795
83GATA2_21666600_ChIP-Seq_HMVEC_Human1.12248588
84SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.10767043
85BCOR_27268052_Chip-Seq_Bcells_Human1.09201856
86PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07219403
87SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06509084
88ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.05650894
89CTCF_27219007_Chip-Seq_ERYTHROID_Human1.03372955
90VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.03076976
91GATA1_22025678_ChIP-Seq_K562_Human0.97546151
92* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97285860
93GATA2_19941826_ChIP-Seq_K562_Human0.95533253
94* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92958744
95* NCOR1_26117541_ChIP-Seq_K562_Human0.92719723
96* SA1_27219007_Chip-Seq_ERYTHROID_Human0.91972559
97SPI1_20517297_ChIP-Seq_HL60_Human0.89209458
98NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.88218194
99RACK7_27058665_Chip-Seq_MCF-7_Human0.87715844
100RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.86933893

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.92781549
2MP0003436_decreased_susceptibility_to4.45349119
3MP0001835_abnormal_antigen_presentation3.74289123
4MP0003303_peritoneal_inflammation3.59712501
5MP0002419_abnormal_innate_immunity3.20856206
6MP0005025_abnormal_response_to2.94981595
7MP0005671_abnormal_response_to2.91130263
8MP0000685_abnormal_immune_system2.84949383
9MP0001800_abnormal_humoral_immune2.83310314
10MP0005000_abnormal_immune_tolerance2.81883011
11MP0005387_immune_system_phenotype2.81089408
12MP0001790_abnormal_immune_system2.81089408
13MP0009785_altered_susceptibility_to2.80280723
14MP0006082_CNS_inflammation2.72638722
15MP0002723_abnormal_immune_serum2.56022084
16MP0002420_abnormal_adaptive_immunity2.53952600
17MP0001819_abnormal_immune_cell2.51134347
18MP0003300_gastrointestinal_ulcer2.49255240
19MP0002452_abnormal_antigen_presenting2.46702540
20MP0003191_abnormal_cellular_cholesterol2.33686923
21MP0001533_abnormal_skeleton_physiology2.29434510
22MP0002148_abnormal_hypersensitivity_rea2.28408466
23MP0005464_abnormal_platelet_physiology2.28008182
24MP0003763_abnormal_thymus_physiology2.25482016
25MP0002405_respiratory_system_inflammati2.02786638
26MP0008260_abnormal_autophagy2.00727828
27MP0002132_abnormal_respiratory_system1.97247625
28MP0003828_pulmonary_edema1.96360767
29MP0002398_abnormal_bone_marrow1.91503934
30MP0010155_abnormal_intestine_physiology1.89414219
31MP0000716_abnormal_immune_system1.87555287
32MP0000465_gastrointestinal_hemorrhage1.81699541
33MP0009278_abnormal_bone_marrow1.81099461
34MP0003172_abnormal_lysosome_physiology1.77405728
35MP0001845_abnormal_inflammatory_respons1.75305518
36MP0004947_skin_inflammation1.70455422
37MP0003866_abnormal_defecation1.70214104
38MP0002396_abnormal_hematopoietic_system1.66629456
39MP0009333_abnormal_splenocyte_physiolog1.63685299
40MP0000689_abnormal_spleen_morphology1.58301055
41MP0002722_abnormal_immune_system1.57733087
42MP0002429_abnormal_blood_cell1.48669304
43MP0003183_abnormal_peptide_metabolism1.47963182
44MP0008469_abnormal_protein_level1.46988931
45MP0001851_eye_inflammation1.43561577
46MP0000703_abnormal_thymus_morphology1.41932483
47MP0009764_decreased_sensitivity_to1.41529423
48MP0004883_abnormal_blood_vessel1.41354748
49MP0000858_altered_metastatic_potential1.39100927
50MP0003075_altered_response_to1.34130843
51MP0005397_hematopoietic_system_phenotyp1.33865257
52MP0001545_abnormal_hematopoietic_system1.33865257
53MP0005058_abnormal_lysosome_morphology1.32344363
54MP0002277_abnormal_respiratory_mucosa1.30293867
55MP0002998_abnormal_bone_remodeling1.29711172
56MP0005451_abnormal_body_composition1.29286637
57MP0004510_myositis1.27974472
58MP0004381_abnormal_hair_follicle1.25905408
59MP0005310_abnormal_salivary_gland1.21152685
60MP0005164_abnormal_response_to1.10839367
61MP0003690_abnormal_glial_cell1.10536068
62MP0005166_decreased_susceptibility_to1.09132825
63MP0002166_altered_tumor_susceptibility1.04778744
64MP0008004_abnormal_stomach_pH1.00776474
65MP0005390_skeleton_phenotype1.00705092
66MP0001873_stomach_inflammation0.97551379
67MP0000343_altered_response_to0.94559766
68MP0003448_altered_tumor_morphology0.93835353
69MP0003806_abnormal_nucleotide_metabolis0.90267012
70MP0001663_abnormal_digestive_system0.90074526
71MP0009763_increased_sensitivity_to0.88188206
72MP0001853_heart_inflammation0.86748719
73MP0002933_joint_inflammation0.84534407
74MP0000490_abnormal_crypts_of0.84394582
75MP0001986_abnormal_taste_sensitivity0.79240029
76MP0003045_fibrosis0.78948826
77MP0000604_amyloidosis0.77704725
78MP0004808_abnormal_hematopoietic_stem0.76234370
79MP0001958_emphysema0.73018872
80MP0003795_abnormal_bone_structure0.72331060
81MP0005075_abnormal_melanosome_morpholog0.71970656
82MP0000249_abnormal_blood_vessel0.69445742
83MP0004130_abnormal_muscle_cell0.66782762
84MP0009765_abnormal_xenobiotic_induced0.65138557
85MP0008874_decreased_physiological_sensi0.64823987
86MP0004858_abnormal_nervous_system0.61721600
87MP0005083_abnormal_biliary_tract0.59886132
88MP0005388_respiratory_system_phenotype0.58801105
89MP0002133_abnormal_respiratory_system0.58801105
90MP0002138_abnormal_hepatobiliary_system0.57437557
91MP0002006_tumorigenesis0.57431838
92MP0003656_abnormal_erythrocyte_physiolo0.57413285
93MP0005319_abnormal_enzyme/_coenzyme0.56350792
94MP0003091_abnormal_cell_migration0.56112570
95MP0000015_abnormal_ear_pigmentation0.55935335
96MP0009840_abnormal_foam_cell0.54300412
97MP0005377_hearing/vestibular/ear_phenot0.52191490
98MP0003878_abnormal_ear_physiology0.52191490
99MP0005381_digestive/alimentary_phenotyp0.50167068
100MP0003566_abnormal_cell_adhesion0.47315159

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.86927983
2Recurrent abscess formation (HP:0002722)6.08280335
3Myositis (HP:0100614)5.91135584
4Recurrent bacterial skin infections (HP:0005406)5.88726153
5Abnormality of macrophages (HP:0004311)5.55948520
6Orchitis (HP:0100796)5.36936096
7Elevated erythrocyte sedimentation rate (HP:0003565)5.05485242
8Stomatitis (HP:0010280)5.00343849
9Recurrent gram-negative bacterial infections (HP:0005420)4.96296080
10Retrobulbar optic neuritis (HP:0100654)4.93162519
11Optic neuritis (HP:0100653)4.93162519
12Obstructive lung disease (HP:0006536)4.24141454
13Chronic obstructive pulmonary disease (HP:0006510)4.24141454
14Gastrointestinal infarctions (HP:0005244)4.17889341
15Recurrent fungal infections (HP:0002841)4.16991000
16Mediastinal lymphadenopathy (HP:0100721)4.07679370
17Meningitis (HP:0001287)3.98179165
18Abnormal delayed hypersensitivity skin test (HP:0002963)3.93150674
19Recurrent skin infections (HP:0001581)3.91115354
20Spontaneous hematomas (HP:0007420)3.78362662
21Increased IgE level (HP:0003212)3.77329908
22Hypochromic microcytic anemia (HP:0004840)3.74492296
23Prolonged bleeding time (HP:0003010)3.69444425
24Encephalitis (HP:0002383)3.67104924
25Keratoconjunctivitis sicca (HP:0001097)3.61089075
26Gingivitis (HP:0000230)3.56338497
27Recurrent cutaneous fungal infections (HP:0011370)3.54606570
28Chronic mucocutaneous candidiasis (HP:0002728)3.54606570
29Urticaria (HP:0001025)3.49245984
30Vasculitis (HP:0002633)3.38030909
31Keratoconjunctivitis (HP:0001096)3.32823909
32Cellulitis (HP:0100658)3.29498307
33Hypochromic anemia (HP:0001931)3.24473704
34Chest pain (HP:0100749)3.21314121
35Episodic fever (HP:0001954)3.20856334
36Petechiae (HP:0000967)3.01779439
37Gingival bleeding (HP:0000225)3.00573199
38Amyloidosis (HP:0011034)3.00339468
39Hemoptysis (HP:0002105)2.98944127
40Epistaxis (HP:0000421)2.96784519
41Pulmonary infiltrates (HP:0002113)2.95257137
42Peritonitis (HP:0002586)2.89634947
43Inflammation of the large intestine (HP:0002037)2.85460785
44T lymphocytopenia (HP:0005403)2.83926661
45Leukocytosis (HP:0001974)2.83581365
46Gastrointestinal inflammation (HP:0004386)2.78882421
47Pustule (HP:0200039)2.77642761
48Abnormality of T cell number (HP:0011839)2.72271057
49Recurrent viral infections (HP:0004429)2.68531794
50Arterial thrombosis (HP:0004420)2.67891916
51Anorexia (HP:0002039)2.64787843
52Panhypogammaglobulinemia (HP:0003139)2.62653905
53Pulmonary embolism (HP:0002204)2.61445220
54Granulocytopenia (HP:0001913)2.54012019
55Purpura (HP:0000979)2.53623112
56Osteomyelitis (HP:0002754)2.53104328
57Increased IgM level (HP:0003496)2.52346834
58Abnormality of T cells (HP:0002843)2.51791216
59Microcytic anemia (HP:0001935)2.47129248
60Hypergammaglobulinemia (HP:0010702)2.33118618
61Sepsis (HP:0100806)2.31032458
62Colitis (HP:0002583)2.27721279
63Lymphopenia (HP:0001888)2.26572543
64Abnormality of the pleura (HP:0002103)2.26436298
65Abnormal platelet volume (HP:0011876)2.25872709
66Hepatosplenomegaly (HP:0001433)2.24474835
67Abnormality of T cell physiology (HP:0011840)2.20965658
68Abnormality of the peritoneum (HP:0002585)2.19576113
69Increased cerebral lipofuscin (HP:0011813)2.19131349
70Gangrene (HP:0100758)2.16415406
71Increased serum ferritin (HP:0003281)2.11427336
72Skin ulcer (HP:0200042)2.11190983
73Glomerulopathy (HP:0100820)2.10703239
74Abnormality of cells of the lymphoid lineage (HP:0012140)2.10637489
75Loss of speech (HP:0002371)2.03579919
76Abnormality of iron homeostasis (HP:0011031)2.03227631
77Abnormality of the endocardium (HP:0004306)2.03196492
78Vertigo (HP:0002321)2.03029020
79Premature loss of primary teeth (HP:0006323)2.02654750
80Eosinophilia (HP:0001880)2.01740633
81Acne (HP:0001061)2.01720297
82Abnormality of glycosphingolipid metabolism (HP:0004343)1.99904780
83Abnormality of glycolipid metabolism (HP:0010969)1.99904780
84Abnormality of liposaccharide metabolism (HP:0010968)1.99904780
85Agammaglobulinemia (HP:0004432)1.99701217
86Abnormality of the pericardium (HP:0001697)1.99393149
87Polycythemia (HP:0001901)1.95794925
88Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.95099447
89Chronic otitis media (HP:0000389)1.93742591
90Slow saccadic eye movements (HP:0000514)1.91870767
91IgM deficiency (HP:0002850)1.90689898
92Skin rash (HP:0000988)1.88863209
93Acute hepatic failure (HP:0006554)1.87314951
94Systemic lupus erythematosus (HP:0002725)1.86756155
95Keratitis (HP:0000491)1.86745507
96Abnormality of the heme biosynthetic pathway (HP:0010472)1.86636809
97Polyneuropathy (HP:0001271)1.80473948
98Recurrent pneumonia (HP:0006532)1.79426279
99Increased neuronal autofluorescent lipopigment (HP:0002074)1.76393071
100Dysostosis multiplex (HP:0000943)1.76041871

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.76989341
2MAP4K13.61671936
3MAP2K33.15685905
4ERN13.09806347
5BLK3.02363259
6IRAK42.93765092
7TYK22.85347769
8FES2.72790203
9CSK2.63436365
10TNK22.49261199
11GRK62.44742515
12PRPF4B2.40427679
13ZAP702.22668318
14EPHB12.19059632
15MAP3K32.00358992
16BTK1.92136588
17TAOK11.87398340
18HCK1.80391254
19MAP3K111.77626773
20JAK31.74502598
21TXK1.70718602
22SYK1.68046919
23FGR1.58778028
24TBK11.43772805
25IKBKE1.38291005
26JAK21.35807834
27LYN1.34754489
28MAP3K141.34313306
29MAP3K11.32682277
30JAK11.32576588
31SIK31.31759939
32MAP3K131.29440864
33KIT1.29309034
34CSF1R1.29272049
35KSR21.24345617
36LCK1.21208854
37TAOK31.18949974
38ITK1.10295345
39TRIB31.07215141
40PRKD21.06291288
41MARK21.06197922
42YES11.04971619
43MARK31.01247899
44TEC1.00091796
45PTK61.00009283
46TAOK20.99961553
47TESK20.98378810
48PDK10.90829441
49TGFBR20.90356340
50STK100.90138591
51CDK190.88924346
52MAP3K60.83328140
53IRAK10.81826734
54PDPK10.81398654
55IKBKB0.80071346
56MAPK120.78156514
57BMPR20.77406039
58SIK20.77218631
59MATK0.76515244
60MAP3K70.76504660
61SMG10.75920845
62IRAK20.73904271
63FYN0.69976550
64MAPK70.69609205
65LRRK20.69588352
66PIK3CG0.67620020
67PTK2B0.65374820
68CDC42BPA0.58964518
69MAP3K20.58490022
70SIK10.57320048
71DYRK1B0.57312850
72HIPK20.56955401
73MAP2K40.56604384
74PRKCQ0.55676679
75MAP3K50.53499205
76EPHA30.52706086
77STK110.51938603
78STK380.49802158
79FGFR40.48071605
80RPS6KC10.46633076
81RPS6KL10.46633076
82RET0.46369908
83SGK30.45671929
84FGFR30.43489503
85PRKG20.43054013
86NLK0.41151699
87MAPKAPK20.40337071
88RAF10.40274785
89MAP2K60.39642669
90PIM10.39380397
91GRK70.39354180
92RPS6KA60.37951299
93CAMKK10.35822381
94DAPK20.35167804
95MAP2K20.31217575
96MOS0.30618618
97PRKCD0.29923265
98PRKCH0.29315198
99PRKD10.29280216
100KSR10.26874504

Predicted pathways (KEGG)

RankGene SetZ-score
1Osteoclast differentiation_Homo sapiens_hsa043803.03983825
2Leishmaniasis_Homo sapiens_hsa051402.96904962
3Staphylococcus aureus infection_Homo sapiens_hsa051502.84667686
4Graft-versus-host disease_Homo sapiens_hsa053322.40807765
5Allograft rejection_Homo sapiens_hsa053302.39067771
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.34481708
7Autoimmune thyroid disease_Homo sapiens_hsa053202.23791905
8B cell receptor signaling pathway_Homo sapiens_hsa046622.20742231
9Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.14136322
10Primary immunodeficiency_Homo sapiens_hsa053402.13877658
11Tuberculosis_Homo sapiens_hsa051522.12102538
12Malaria_Homo sapiens_hsa051441.92430419
13Toll-like receptor signaling pathway_Homo sapiens_hsa046201.90012326
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.79995218
15Acute myeloid leukemia_Homo sapiens_hsa052211.75715886
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.75211793
17Type I diabetes mellitus_Homo sapiens_hsa049401.73224978
18Hematopoietic cell lineage_Homo sapiens_hsa046401.72383858
19Antigen processing and presentation_Homo sapiens_hsa046121.69604198
20Chemokine signaling pathway_Homo sapiens_hsa040621.69294203
21Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.68333059
22Measles_Homo sapiens_hsa051621.67655351
23Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.66867275
24T cell receptor signaling pathway_Homo sapiens_hsa046601.63287171
25Viral myocarditis_Homo sapiens_hsa054161.62668662
26Toxoplasmosis_Homo sapiens_hsa051451.52531239
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.46379056
28Other glycan degradation_Homo sapiens_hsa005111.44848329
29Phagosome_Homo sapiens_hsa041451.43113985
30Legionellosis_Homo sapiens_hsa051341.40862555
31Influenza A_Homo sapiens_hsa051641.40476241
32Leukocyte transendothelial migration_Homo sapiens_hsa046701.36369071
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.33276465
34Jak-STAT signaling pathway_Homo sapiens_hsa046301.31725307
35Platelet activation_Homo sapiens_hsa046111.31463658
36Intestinal immune network for IgA production_Homo sapiens_hsa046721.28541889
37Herpes simplex infection_Homo sapiens_hsa051681.28329739
38African trypanosomiasis_Homo sapiens_hsa051431.28273740
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.26339103
40Asthma_Homo sapiens_hsa053101.23766157
41TNF signaling pathway_Homo sapiens_hsa046681.20372569
42Non-small cell lung cancer_Homo sapiens_hsa052231.16369874
43Pertussis_Homo sapiens_hsa051331.11402733
44Hepatitis B_Homo sapiens_hsa051611.06420741
45Shigellosis_Homo sapiens_hsa051311.03956534
46Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.01958167
47Salmonella infection_Homo sapiens_hsa051321.00746801
48Hepatitis C_Homo sapiens_hsa051601.00034906
49Pancreatic cancer_Homo sapiens_hsa052120.98789753
50Chronic myeloid leukemia_Homo sapiens_hsa052200.94875749
51VEGF signaling pathway_Homo sapiens_hsa043700.94122646
52Rheumatoid arthritis_Homo sapiens_hsa053230.93905407
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91117430
54Endocytosis_Homo sapiens_hsa041440.87778067
55Apoptosis_Homo sapiens_hsa042100.86562583
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.83573001
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83115664
58Lysosome_Homo sapiens_hsa041420.81561461
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.78265853
60Renal cell carcinoma_Homo sapiens_hsa052110.76890371
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.76489638
62Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.75725521
63SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75433491
64Prolactin signaling pathway_Homo sapiens_hsa049170.74219722
65Sphingolipid signaling pathway_Homo sapiens_hsa040710.73163270
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71812328
67AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71421749
68Amoebiasis_Homo sapiens_hsa051460.70053672
69Glycosaminoglycan degradation_Homo sapiens_hsa005310.65931953
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.65832869
71Notch signaling pathway_Homo sapiens_hsa043300.65695396
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64299838
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63419504
74GnRH signaling pathway_Homo sapiens_hsa049120.63188651
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63032006
76Choline metabolism in cancer_Homo sapiens_hsa052310.62261422
77Epstein-Barr virus infection_Homo sapiens_hsa051690.61194466
78FoxO signaling pathway_Homo sapiens_hsa040680.61107989
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57782259
80Endometrial cancer_Homo sapiens_hsa052130.57728531
81Viral carcinogenesis_Homo sapiens_hsa052030.57641025
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55554673
83HTLV-I infection_Homo sapiens_hsa051660.54410789
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54329874
85Regulation of autophagy_Homo sapiens_hsa041400.53887732
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.50827299
87Colorectal cancer_Homo sapiens_hsa052100.50598590
88Inositol phosphate metabolism_Homo sapiens_hsa005620.49243012
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48600251
90Rap1 signaling pathway_Homo sapiens_hsa040150.48482342
91Insulin resistance_Homo sapiens_hsa049310.48138218
92HIF-1 signaling pathway_Homo sapiens_hsa040660.47580885
93MAPK signaling pathway_Homo sapiens_hsa040100.46770663
94Dorso-ventral axis formation_Homo sapiens_hsa043200.43954249
95mTOR signaling pathway_Homo sapiens_hsa041500.43213913
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39576278
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39262715
98Type II diabetes mellitus_Homo sapiens_hsa049300.37175596
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35460920
100Estrogen signaling pathway_Homo sapiens_hsa049150.33925310

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