ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of nitric oxide biosynthetic process (GO:0045019)	4.13541768
2	regulation of metalloenzyme activity (GO:0048552)	4.05035196
3	positive regulation of defense response to virus by host (GO:0002230)	3.61759891
4	nuclear envelope reassembly (GO:0031468)	3.58030854
5	mitotic nuclear envelope reassembly (GO:0007084)	3.58030854
6	regulation of vitamin D biosynthetic process (GO:0060556)	3.58024237
7	DNA deamination (GO:0045006)	3.54899639
8	lipopolysaccharide biosynthetic process (GO:0009103)	3.54423659
9	response to gravity (GO:0009629)	3.53626196
10	activation of MAPKKK activity (GO:0000185)	3.46997285
11	leukocyte aggregation (GO:0070486)	3.22201935
12	negative regulation of interleukin-17 production (GO:0032700)	3.19514549
13	lipopolysaccharide metabolic process (GO:0008653)	3.19032107
14	response to peptidoglycan (GO:0032494)	3.18501797
15	mesodermal cell differentiation (GO:0048333)	3.11034542
16	negative regulation of mast cell activation (GO:0033004)	3.09320085
17	muscle cell migration (GO:0014812)	3.06718416
18	cellular response to zinc ion (GO:0071294)	3.06714529
19	positive regulation of interleukin-8 secretion (GO:2000484)	3.06238199
20	purine nucleotide salvage (GO:0032261)	3.04427838
21	regulation of apoptotic process involved in morphogenesis (GO:1902337)	3.03352705
22	C-terminal protein lipidation (GO:0006501)	2.97824690
23	cellular response to arsenic-containing substance (GO:0071243)	2.97312619
24	protein maturation by protein folding (GO:0022417)	2.90954657
25	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.90003348
26	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.90003348
27	induction of positive chemotaxis (GO:0050930)	2.87397039
28	positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)	2.84213754
29	platelet dense granule organization (GO:0060155)	2.83935771
30	morphogenesis of an endothelium (GO:0003159)	2.82488422
31	endothelial tube morphogenesis (GO:0061154)	2.82488422
32	I-kappaB kinase/NF-kappaB signaling (GO:0007249)	2.79478334
33	fibrinolysis (GO:0042730)	2.79475695
34	membrane raft organization (GO:0031579)	2.79029915
35	regulation of vitamin metabolic process (GO:0030656)	2.76724118
36	positive regulation of mitochondrial fission (GO:0090141)	2.76593474
37	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	2.75139889
38	regulation of interleukin-8 secretion (GO:2000482)	2.73372670
39	regulation of defense response to virus by host (GO:0050691)	2.73135362
40	positive regulation of mitochondrial calcium ion concentration (GO:0051561)	2.72142244
41	positive regulation of monocyte chemotaxis (GO:0090026)	2.70748183
42	positive regulation of actin filament depolymerization (GO:0030836)	2.70130413
43	regulation of chemokine biosynthetic process (GO:0045073)	2.69084664
44	eosinophil chemotaxis (GO:0048245)	2.69072628
45	nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)	2.68944498
46	mannosylation (GO:0097502)	2.68164273
47	positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)	2.67690005
48	rRNA transcription (GO:0009303)	2.64587416
49	positive regulation of chemokine biosynthetic process (GO:0045080)	2.63696879
50	galactose metabolic process (GO:0006012)	2.62300348
51	response to interferon-beta (GO:0035456)	2.60810384
52	negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)	2.59549628
53	regulation of cytokine secretion involved in immune response (GO:0002739)	2.59127589
54	establishment of viral latency (GO:0019043)	2.58078728
55	C-terminal protein amino acid modification (GO:0018410)	2.54215933
56	sphingosine metabolic process (GO:0006670)	2.53789560
57	negative regulation of interleukin-1 production (GO:0032692)	2.53438705
58	pyrimidine-containing compound transmembrane transport (GO:0072531)	2.51433028
59	cullin deneddylation (GO:0010388)	2.48744391
60	positive regulation of signal transduction by p53 class mediator (GO:1901798)	2.47902372
61	regulation of odontogenesis of dentin-containing tooth (GO:0042487)	2.47722586
62	intracellular pH reduction (GO:0051452)	2.47150302
63	fusion of sperm to egg plasma membrane (GO:0007342)	2.47128128
64	regulation of nitric oxide biosynthetic process (GO:0045428)	2.46989621
65	proteasome assembly (GO:0043248)	2.44243991
66	negative regulation of mitochondrion organization (GO:0010823)	2.42327209
67	regulation of positive chemotaxis (GO:0050926)	2.40751120
68	positive regulation of positive chemotaxis (GO:0050927)	2.39499113
69	regulation of interleukin-17 production (GO:0032660)	2.38792484
70	NIK/NF-kappaB signaling (GO:0038061)	2.38626691
71	cell adhesion mediated by integrin (GO:0033627)	2.38537281
72	eosinophil migration (GO:0072677)	2.38420571
73	regulation of thymocyte apoptotic process (GO:0070243)	2.38368902
74	negative regulation of nitric-oxide synthase activity (GO:0051001)	2.37165650
75	response to hyperoxia (GO:0055093)	2.35093274
76	response to increased oxygen levels (GO:0036296)	2.35093274
77	maintenance of protein location in nucleus (GO:0051457)	2.35047263
78	regulation of integrin-mediated signaling pathway (GO:2001044)	2.34588906
79	response to protozoan (GO:0001562)	2.34505174
80	lung vasculature development (GO:0060426)	2.32962293
81	negative regulation of tumor necrosis factor production (GO:0032720)	2.32251938
82	myelin assembly (GO:0032288)	2.31448455
83	positive regulation of TOR signaling (GO:0032008)	2.31214350
84	negative regulation of JAK-STAT cascade (GO:0046426)	2.31205708
85	negative regulation of interleukin-12 production (GO:0032695)	2.31069611
86	tRNA methylation (GO:0030488)	2.30921148
87	regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)	2.30882096
88	positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)	2.30882096
89	regulation of mitochondrial fission (GO:0090140)	2.30655422
90	nucleotide salvage (GO:0043173)	2.30055244
91	positive regulation of protein homooligomerization (GO:0032464)	2.29465257
92	protein deneddylation (GO:0000338)	2.29228878
93	virion attachment to host cell (GO:0019062)	2.28889100
94	adhesion of symbiont to host cell (GO:0044650)	2.28889100
95	positive regulation of pseudopodium assembly (GO:0031274)	2.28213538
96	substrate-dependent cell migration (GO:0006929)	2.27951035
97	defense response to protozoan (GO:0042832)	2.27865755
98	amino sugar catabolic process (GO:0046348)	2.27098639
99	endosome to pigment granule transport (GO:0043485)	2.26992796
100	endosome to melanosome transport (GO:0035646)	2.26992796

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.89230670
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.72142429
3	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	3.70973631
4	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.57887132
5	* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	3.25019977
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.79587903
7	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	2.74770103
8	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.59054528
9	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.55177433
10	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.49807159
11	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.27386334
12	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	2.12953243
13	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	2.11485652
14	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.10633245
15	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.04744373
16	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.03681612
17	ELK1_22589737_ChIP-Seq_MCF10A_Human	2.01557102
18	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.97821647
19	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.97821647
20	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.94170638
21	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.87027272
22	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.86159375
23	CJUN_26792858_Chip-Seq_BT549_Human	1.84370550
24	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.82034979
25	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.78977326
26	ELK1_19687146_ChIP-ChIP_HELA_Human	1.78591066
27	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.75407939
28	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.75083073
29	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.74601539
30	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.72003227
31	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.71412867
32	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.69848779
33	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.69697088
34	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.67084606
35	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.65926049
36	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.65157022
37	BRD4_25478319_ChIP-Seq_HGPS_Human	1.61714982
38	VDR_23849224_ChIP-Seq_CD4+_Human	1.61124038
39	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.60841625
40	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.59383922
41	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.57073167
42	SPI1_23547873_ChIP-Seq_NB4_Human	1.55420997
43	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.54621757
44	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.51970162
45	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.50332482
46	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.48954211
47	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.45705657
48	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.45161790
49	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.44237479
50	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.41740968
51	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.41183237
52	GABP_19822575_ChIP-Seq_HepG2_Human	1.39532368
53	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.37551084
54	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.36606417
55	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.31361093
56	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.30735876
57	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.29989807
58	MYB_21317192_ChIP-Seq_ERMYB_Mouse	1.29725052
59	ATF3_27146783_Chip-Seq_COLON_Human	1.26027837
60	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.25436252
61	STAT1_20625510_ChIP-Seq_HELA_Human	1.24847295
62	ZNF274_21170338_ChIP-Seq_K562_Hela	1.23718447
63	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.23238887
64	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.22770396
65	TP53_22127205_ChIP-Seq_IMR90_Human	1.21941535
66	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.21878941
67	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.20468042
68	BCL6_27268052_Chip-Seq_Bcells_Human	1.19516258
69	FOXP3_21729870_ChIP-Seq_TREG_Human	1.19032585
70	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	1.18350950
71	IRF8_27001747_Chip-Seq_BMDM_Mouse	1.16854419
72	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.13163422
73	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.10614974
74	BCOR_27268052_Chip-Seq_Bcells_Human	1.10170587
75	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.08409556
76	VDR_24787735_ChIP-Seq_THP-1_Human	1.05810250
77	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.05578907
78	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.04404607
79	DCP1A_22483619_ChIP-Seq_HELA_Human	1.04050284
80	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.03769181
81	ELF5_23300383_ChIP-Seq_T47D_Human	1.03561595
82	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.02613075
83	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.02606746
84	SPI1_20517297_ChIP-Seq_HL60_Human	1.02004292
85	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.00987335
86	P300_27268052_Chip-Seq_Bcells_Human	1.00259213
87	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.98346058
88	TP53_16413492_ChIP-PET_HCT116_Human	0.97532254
89	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	0.95379086
90	VDR_24763502_ChIP-Seq_THP-1_Human	0.95315035
91	TFEB_21752829_ChIP-Seq_HELA_Human	0.95000250
92	* P63_26484246_Chip-Seq_KERATINOCYTES_Human	0.94070086
93	* GATA3_26560356_Chip-Seq_TH2_Human	0.92914298
94	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.92676582
95	CSB_26484114_Chip-Seq_FIBROBLAST_Human	0.90528669
96	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	0.89880764
97	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.89746036
98	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.89635548
99	ESR1_21235772_ChIP-Seq_MCF-7_Human	0.89299236
100	SPI1_23127762_ChIP-Seq_K562_Human	0.87974224

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005623_abnormal_meninges_morphology	3.56169560
2	MP0000750_abnormal_muscle_regeneration	3.42978064
3	MP0006054_spinal_hemorrhage	3.10462285
4	MP0003436_decreased_susceptibility_to	2.97253016
5	MP0003191_abnormal_cellular_cholesterol	2.87369914
6	MP0009764_decreased_sensitivity_to	2.75430818
7	MP0009840_abnormal_foam_cell	2.66364061
8	MP0000013_abnormal_adipose_tissue	2.58627155
9	MP0002254_reproductive_system_inflammat	2.53770186
10	MP0003950_abnormal_plasma_membrane	2.53158253
11	MP0002332_abnormal_exercise_endurance	2.53027620
12	MP0002148_abnormal_hypersensitivity_rea	2.41812430
13	MP0004510_myositis	2.23906484
14	MP0000858_altered_metastatic_potential	2.16101143
15	MP0000343_altered_response_to	2.00684601
16	MP0003786_premature_aging	1.98546011
17	MP0005164_abnormal_response_to	1.97788552
18	MP0003724_increased_susceptibility_to	1.96832328
19	MP0005410_abnormal_fertilization	1.94643060
20	MP0001542_abnormal_bone_strength	1.90406021
21	MP0004947_skin_inflammation	1.82491852
22	MP0003656_abnormal_erythrocyte_physiolo	1.82057003
23	MP0009785_altered_susceptibility_to	1.81908356
24	MP0001853_heart_inflammation	1.79474750
25	MP0002419_abnormal_innate_immunity	1.79441850
26	MP0006082_CNS_inflammation	1.74384370
27	MP0003195_calcinosis	1.72752782
28	MP0003279_aneurysm	1.72674842
29	MP0003075_altered_response_to	1.71242739
30	MP0005257_abnormal_intraocular_pressure	1.70279177
31	MP0001533_abnormal_skeleton_physiology	1.63517393
32	MP0005058_abnormal_lysosome_morphology	1.54606421
33	MP0002877_abnormal_melanocyte_morpholog	1.52188789
34	MP0005000_abnormal_immune_tolerance	1.50570324
35	MP0001835_abnormal_antigen_presentation	1.46311264
36	MP0002452_abnormal_antigen_presenting	1.45768609
37	MP0005165_increased_susceptibility_to	1.42461943
38	MP0005166_decreased_susceptibility_to	1.39599436
39	MP0008438_abnormal_cutaneous_collagen	1.39580097
40	MP0003806_abnormal_nucleotide_metabolis	1.38426468
41	MP0003186_abnormal_redox_activity	1.37420687
42	MP0008004_abnormal_stomach_pH	1.36588337
43	MP0002723_abnormal_immune_serum	1.32083580
44	MP0008469_abnormal_protein_level	1.31022763
45	MP0000749_muscle_degeneration	1.28013165
46	MP0005464_abnormal_platelet_physiology	1.24378214
47	MP0005360_urolithiasis	1.23247261
48	MP0005025_abnormal_response_to	1.21331400
49	MP0008260_abnormal_autophagy	1.14742358
50	MP0000372_irregular_coat_pigmentation	1.14631154
51	MP0001545_abnormal_hematopoietic_system	1.09607814
52	MP0005397_hematopoietic_system_phenotyp	1.09607814
53	MP0005390_skeleton_phenotype	1.08498901
54	MP0001243_abnormal_dermal_layer	1.07846169
55	MP0002282_abnormal_trachea_morphology	1.06641177
56	MP0001845_abnormal_inflammatory_respons	1.06402425
57	MP0009333_abnormal_splenocyte_physiolog	1.06234354
58	MP0003448_altered_tumor_morphology	1.05839754
59	MP0009765_abnormal_xenobiotic_induced	1.05506162
60	MP0003566_abnormal_cell_adhesion	1.04730250
61	MP0002405_respiratory_system_inflammati	1.03677175
62	MP0005367_renal/urinary_system_phenotyp	1.03652740
63	MP0000516_abnormal_urinary_system	1.03652740
64	MP0005451_abnormal_body_composition	1.03534280
65	MP0000604_amyloidosis	1.02848911
66	MP0009384_cardiac_valve_regurgitation	1.02682400
67	MP0000762_abnormal_tongue_morphology	1.02326138
68	MP0004272_abnormal_basement_membrane	1.01665446
69	MP0002132_abnormal_respiratory_system	1.01265685
70	MP0010368_abnormal_lymphatic_system	1.00176680
71	MP0001819_abnormal_immune_cell	0.99530516
72	MP0002420_abnormal_adaptive_immunity	0.98814067
73	MP0002060_abnormal_skin_morphology	0.95518506
74	MP0002177_abnormal_outer_ear	0.95490374
75	MP0001800_abnormal_humoral_immune	0.95102443
76	MP0008007_abnormal_cellular_replicative	0.94227411
77	MP0009697_abnormal_copulation	0.93157346
78	MP0008775_abnormal_heart_ventricle	0.93003771
79	MP0009278_abnormal_bone_marrow	0.92013425
80	MP0001790_abnormal_immune_system	0.91261050
81	MP0005387_immune_system_phenotype	0.91261050
82	MP0000358_abnormal_cell_content/	0.86886675
83	MP0005023_abnormal_wound_healing	0.85128385
84	MP0009763_increased_sensitivity_to	0.84823932
85	MP0005197_abnormal_uvea_morphology	0.84213621
86	MP0000647_abnormal_sebaceous_gland	0.83417339
87	MP0000249_abnormal_blood_vessel	0.81579880
88	MP0002933_joint_inflammation	0.81224709
89	MP0000427_abnormal_hair_cycle	0.79154236
90	MP0002168_other_aberrant_phenotype	0.78723295
91	MP0003828_pulmonary_edema	0.78467926
92	MP0005584_abnormal_enzyme/coenzyme_acti	0.74530777
93	MP0005376_homeostasis/metabolism_phenot	0.73687369
94	MP0004147_increased_porphyrin_level	0.73430488
95	MP0008873_increased_physiological_sensi	0.73087355
96	MP0000685_abnormal_immune_system	0.72939439
97	MP0005167_abnormal_blood-brain_barrier	0.71894829
98	MP0001216_abnormal_epidermal_layer	0.70386292
99	MP0002277_abnormal_respiratory_mucosa	0.70102496
100	MP0000751_myopathy	0.69950982

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Type II lissencephaly (HP:0007260)	6.40882967
2	Cerebellar dysplasia (HP:0007033)	6.12986933
3	Fatigue (HP:0012378)	5.39650124
4	Retinal atrophy (HP:0001105)	5.38025883
5	Retinal dysplasia (HP:0007973)	5.34731531
6	Decreased electroretinogram (ERG) amplitude (HP:0000654)	5.06043080
7	Elevated erythrocyte sedimentation rate (HP:0003565)	4.70950230
8	Hypoplasia of the pons (HP:0012110)	4.65626882
9	Difficulty climbing stairs (HP:0003551)	4.48278537
10	Abnormality of the pons (HP:0007361)	4.18582297
11	Abnormality of glycolipid metabolism (HP:0010969)	3.81757131
12	Abnormality of liposaccharide metabolism (HP:0010968)	3.81757131
13	Abnormality of glycosphingolipid metabolism (HP:0004343)	3.81757131
14	Entropion (HP:0000621)	3.70617615
15	Severe muscular hypotonia (HP:0006829)	3.63498231
16	Amyloidosis (HP:0011034)	3.39155897
17	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.21550559
18	Abnormality of alanine metabolism (HP:0010916)	3.21550559
19	Hyperalaninemia (HP:0003348)	3.21550559
20	Vacuolated lymphocytes (HP:0001922)	3.00554817
21	Abolished electroretinogram (ERG) (HP:0000550)	2.93112558
22	Reduced subcutaneous adipose tissue (HP:0003758)	2.76649489
23	Buphthalmos (HP:0000557)	2.74370567
24	Aplasia/Hypoplasia affecting the retina (HP:0008061)	2.66844969
25	Premature rupture of membranes (HP:0001788)	2.63521234
26	Stomatitis (HP:0010280)	2.58647225
27	Abnormal protein glycosylation (HP:0012346)	2.53422761
28	Abnormal glycosylation (HP:0012345)	2.53422761
29	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.53422761
30	Abnormal protein N-linked glycosylation (HP:0012347)	2.53422761
31	Glucose intolerance (HP:0000833)	2.53290302
32	Follicular hyperkeratosis (HP:0007502)	2.46922712
33	Decreased subcutaneous fat (HP:0001002)	2.42541513
34	Myocardial infarction (HP:0001658)	2.41193079
35	Abnormality of glycosaminoglycan metabolism (HP:0004371)	2.40209717
36	Abnormality of mucopolysaccharide metabolism (HP:0011020)	2.40209717
37	Abnormality of polysaccharide metabolism (HP:0011012)	2.40209717
38	Concave nail (HP:0001598)	2.23549354
39	Type I transferrin isoform profile (HP:0003642)	2.22738782
40	Brittle hair (HP:0002299)	2.20713851
41	Congenital glaucoma (HP:0001087)	2.20387050
42	Increased IgM level (HP:0003496)	2.16958506
43	Thick nail (HP:0001805)	2.13148149
44	IgG deficiency (HP:0004315)	2.12859132
45	Prolonged neonatal jaundice (HP:0006579)	2.11774956
46	Delayed CNS myelination (HP:0002188)	2.09436209
47	Adactyly (HP:0009776)	2.08215625
48	Lissencephaly (HP:0001339)	2.08090990
49	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.05360038
50	Atrophic scars (HP:0001075)	2.03121149
51	Muscular dystrophy (HP:0003560)	1.99198636
52	Reduced antithrombin III activity (HP:0001976)	1.98318415
53	Upper limb muscle weakness (HP:0003484)	1.98203506
54	Dysostosis multiplex (HP:0000943)	1.96788595
55	Fragile nails (HP:0001808)	1.95494584
56	Delayed gross motor development (HP:0002194)	1.92758671
57	Keratitis (HP:0000491)	1.90975889
58	Urinary glycosaminoglycan excretion (HP:0003541)	1.90432241
59	Mucopolysacchariduria (HP:0008155)	1.90432241
60	Abnormality of macrophages (HP:0004311)	1.88978023
61	Sparse eyelashes (HP:0000653)	1.88729806
62	Axonal loss (HP:0003447)	1.87690434
63	Neonatal respiratory distress (HP:0002643)	1.82241636
64	Increased neuronal autofluorescent lipopigment (HP:0002074)	1.79986320
65	Absent speech (HP:0001344)	1.78185564
66	Short nail (HP:0001799)	1.78106844
67	Peritonitis (HP:0002586)	1.78072468
68	Increased cerebral lipofuscin (HP:0011813)	1.77661599
69	Poikiloderma (HP:0001029)	1.77479514
70	Increased serum pyruvate (HP:0003542)	1.76390579
71	Impaired platelet aggregation (HP:0003540)	1.75287853
72	Abnormal platelet function (HP:0011869)	1.75287853
73	Flat capital femoral epiphysis (HP:0003370)	1.75216207
74	Abnormal spermatogenesis (HP:0008669)	1.75019769
75	Hepatocellular necrosis (HP:0001404)	1.74903561
76	Myositis (HP:0100614)	1.73936284
77	Erythroderma (HP:0001019)	1.73916421
78	Adrenal hypoplasia (HP:0000835)	1.71432643
79	Meningocele (HP:0002435)	1.70978960
80	Bradycardia (HP:0001662)	1.70544529
81	Cone-rod dystrophy (HP:0000548)	1.68445649
82	Onycholysis (HP:0001806)	1.67357198
83	Rough bone trabeculation (HP:0100670)	1.67264117
84	Orchitis (HP:0100796)	1.66872979
85	Conical tooth (HP:0000698)	1.64843106
86	Delayed closure of the anterior fontanelle (HP:0001476)	1.64733370
87	Anorexia (HP:0002039)	1.61250635
88	Constricted visual fields (HP:0001133)	1.60195076
89	Alopecia of scalp (HP:0002293)	1.59986586
90	Increased serum ferritin (HP:0003281)	1.59023856
91	Joint stiffness (HP:0001387)	1.57198823
92	Abnormality of subcutaneous fat tissue (HP:0001001)	1.56143524
93	Submucous cleft hard palate (HP:0000176)	1.56105213
94	Gowers sign (HP:0003391)	1.54841318
95	Choroideremia (HP:0001139)	1.53604236
96	Nail dystrophy (HP:0008404)	1.51750767
97	IgA deficiency (HP:0002720)	1.51109993
98	Joint hemorrhage (HP:0005261)	1.50861445
99	Severe visual impairment (HP:0001141)	1.50110971
100	Large eyes (HP:0001090)	1.49148563

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	IRAK3	4.14365718
2	STK10	3.62569712
3	EPHA2	3.21402416
4	TESK2	3.15305462
5	TESK1	3.13178835
6	NME2	3.02245353
7	LIMK1	2.68068325
8	PIM2	2.64439984
9	MARK3	2.59451820
10	PDK2	2.33656702
11	MAP3K3	2.30556003
12	VRK2	2.23670698
13	MAP3K11	1.97199282
14	TRIM28	1.83691461
15	GRK7	1.71957316
16	TLK1	1.71604062
17	MAP3K14	1.71558816
18	ERN1	1.70731082
19	PTK2B	1.68440375
20	IKBKB	1.68005337
21	TGFBR2	1.64507920
22	SIK3	1.62349320
23	LMTK2	1.57970860
24	TAOK2	1.56344025
25	ZAK	1.56017832
26	MST1R	1.45470352
27	MAP3K12	1.40168168
28	MAP2K3	1.39456987
29	ABL2	1.36223168
30	ERBB4	1.33070067
31	ADRBK2	1.20389338
32	MOS	1.18666666
33	TBK1	1.17889318
34	TAOK3	1.16219221
35	BCKDK	1.13346910
36	IRAK1	1.10095354
37	TXK	1.05564059
38	MAP2K7	1.03311937
39	ARAF	1.01853936
40	FLT3	1.00267272
41	PIM1	0.98494858
42	MYLK	0.97071687
43	FRK	0.94634166
44	PAK4	0.92106100
45	ADRBK1	0.91394224
46	IKBKE	0.90358060
47	PRKCI	0.87178513
48	MST4	0.85430485
49	BRSK2	0.84485514
50	EPHB1	0.83540078
51	NUAK1	0.83122409
52	VRK1	0.80709385
53	CHUK	0.80705730
54	CSNK1G3	0.80049787
55	CSNK1A1L	0.74714210
56	MUSK	0.72351607
57	GSK3A	0.67187903
58	CCNB1	0.66012288
59	EPHA3	0.61565541
60	GRK1	0.60431710
61	CDK8	0.58883462
62	RPS6KA5	0.58097959
63	EPHB2	0.55928952
64	CSNK1G1	0.51080758
65	JAK3	0.50699529
66	IRAK2	0.48045073
67	BUB1	0.47987930
68	PRKD2	0.46624965
69	DAPK1	0.46611664
70	GRK5	0.46551704
71	ZAP70	0.44645488
72	PRKCE	0.43920017
73	RPS6KA4	0.43811573
74	CSNK1G2	0.42499470
75	MET	0.40797209
76	AURKA	0.39606455
77	PRKG2	0.39445413
78	TYK2	0.39031308
79	STK16	0.38395123
80	FER	0.38024928
81	PTK2	0.37526072
82	MAP3K5	0.37487744
83	IRAK4	0.37407943
84	CAMKK2	0.37054747
85	ERBB3	0.36907104
86	MAP4K2	0.35252522
87	KIT	0.33891639
88	BMPR1B	0.32476618
89	ABL1	0.31369660
90	PIK3CG	0.31157748
91	MAP4K1	0.29738266
92	ROCK1	0.29553355
93	KDR	0.29022113
94	EIF2AK2	0.28273584
95	MAPK11	0.26373691
96	SRPK1	0.25980409
97	DDR2	0.25018481
98	BLK	0.25018132
99	DAPK3	0.24493910
100	PRKD1	0.24475133

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Sulfur metabolism_Homo sapiens_hsa00920	2.90998009
2	Proteasome_Homo sapiens_hsa03050	2.76267508
3	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	2.68532202
4	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	2.60617212
5	Glycosaminoglycan degradation_Homo sapiens_hsa00531	2.56048513
6	NF-kappa B signaling pathway_Homo sapiens_hsa04064	2.45069897
7	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	2.31687340
8	Other glycan degradation_Homo sapiens_hsa00511	2.29252628
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.20345595
10	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.18116987
11	Legionellosis_Homo sapiens_hsa05134	2.10332639
12	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	2.08304376
13	Sulfur relay system_Homo sapiens_hsa04122	2.02530412
14	Rheumatoid arthritis_Homo sapiens_hsa05323	1.97914268
15	TNF signaling pathway_Homo sapiens_hsa04668	1.97492017
16	Lysosome_Homo sapiens_hsa04142	1.83921877
17	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.79818701
18	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.78371550
19	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.50927055
20	Leishmaniasis_Homo sapiens_hsa05140	1.49238492
21	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	1.47975572
22	Graft-versus-host disease_Homo sapiens_hsa05332	1.43906643
23	Salmonella infection_Homo sapiens_hsa05132	1.42287716
24	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.41856905
25	Shigellosis_Homo sapiens_hsa05131	1.40283171
26	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.38501941
27	Glutathione metabolism_Homo sapiens_hsa00480	1.36362911
28	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.34744341
29	Allograft rejection_Homo sapiens_hsa05330	1.34232346
30	RNA polymerase_Homo sapiens_hsa03020	1.29611632
31	Osteoclast differentiation_Homo sapiens_hsa04380	1.28101233
32	Toxoplasmosis_Homo sapiens_hsa05145	1.27478230
33	Pertussis_Homo sapiens_hsa05133	1.23568078
34	p53 signaling pathway_Homo sapiens_hsa04115	1.23103025
35	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.22987080
36	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.19047964
37	Tuberculosis_Homo sapiens_hsa05152	1.18281619
38	Homologous recombination_Homo sapiens_hsa03440	1.16775981
39	Galactose metabolism_Homo sapiens_hsa00052	1.14672713
40	Pyrimidine metabolism_Homo sapiens_hsa00240	1.13322985
41	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.10105069
42	Regulation of autophagy_Homo sapiens_hsa04140	1.07764413
43	Basal transcription factors_Homo sapiens_hsa03022	1.07548617
44	Phagosome_Homo sapiens_hsa04145	1.07529335
45	African trypanosomiasis_Homo sapiens_hsa05143	1.06690156
46	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.06466135
47	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.05258238
48	Herpes simplex infection_Homo sapiens_hsa05168	1.04161749
49	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.02583514
50	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.00347844
51	Type I diabetes mellitus_Homo sapiens_hsa04940	0.99644932
52	Collecting duct acid secretion_Homo sapiens_hsa04966	0.97558259
53	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.97190080
54	Malaria_Homo sapiens_hsa05144	0.95981001
55	Sphingolipid metabolism_Homo sapiens_hsa00600	0.94426354
56	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.93760496
57	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.91973465
58	Oxidative phosphorylation_Homo sapiens_hsa00190	0.91587922
59	Influenza A_Homo sapiens_hsa05164	0.91407272
60	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.90735954
61	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.86422290
62	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.84386175
63	Base excision repair_Homo sapiens_hsa03410	0.83704809
64	Asthma_Homo sapiens_hsa05310	0.83690263
65	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.81253635
66	Antigen processing and presentation_Homo sapiens_hsa04612	0.81240329
67	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.80085978
68	Apoptosis_Homo sapiens_hsa04210	0.79679701
69	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.70308402
70	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.70177692
71	Folate biosynthesis_Homo sapiens_hsa00790	0.69498807
72	Viral carcinogenesis_Homo sapiens_hsa05203	0.69067415
73	Selenocompound metabolism_Homo sapiens_hsa00450	0.68467296
74	Mineral absorption_Homo sapiens_hsa04978	0.68376818
75	Alcoholism_Homo sapiens_hsa05034	0.68115113
76	Fatty acid elongation_Homo sapiens_hsa00062	0.67811649
77	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.65978047
78	Complement and coagulation cascades_Homo sapiens_hsa04610	0.65147223
79	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.64642981
80	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.63751058
81	Measles_Homo sapiens_hsa05162	0.63638111
82	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.62947562
83	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.61845808
84	Vibrio cholerae infection_Homo sapiens_hsa05110	0.60586093
85	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.59625041
86	Bladder cancer_Homo sapiens_hsa05219	0.57660758
87	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.55548795
88	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.55020247
89	Protein export_Homo sapiens_hsa03060	0.54444670
90	Pentose phosphate pathway_Homo sapiens_hsa00030	0.53843594
91	Huntingtons disease_Homo sapiens_hsa05016	0.53447377
92	Viral myocarditis_Homo sapiens_hsa05416	0.52255322
93	Phototransduction_Homo sapiens_hsa04744	0.49999017
94	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.48963096
95	Circadian rhythm_Homo sapiens_hsa04710	0.48711039
96	Nucleotide excision repair_Homo sapiens_hsa03420	0.47741924
97	Hepatitis B_Homo sapiens_hsa05161	0.46744808
98	Purine metabolism_Homo sapiens_hsa00230	0.45757656
99	Salivary secretion_Homo sapiens_hsa04970	0.43737636
100	Peroxisome_Homo sapiens_hsa04146	0.43661251

C10ORF55

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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