C10ORF62

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)9.98861580
2chromosome condensation (GO:0030261)9.60736848
3DNA packaging (GO:0006323)9.48104517
4spermatid development (GO:0007286)8.88277401
5spermatid nucleus differentiation (GO:0007289)8.66567627
6single strand break repair (GO:0000012)8.50721283
7microtubule depolymerization (GO:0007019)7.89432840
8response to pheromone (GO:0019236)7.87685439
9plasma membrane fusion (GO:0045026)7.57353588
10phosphatidylethanolamine biosynthetic process (GO:0006646)7.48575680
11negative regulation of inclusion body assembly (GO:0090084)7.39727369
12sperm-egg recognition (GO:0035036)7.35857742
13sexual reproduction (GO:0019953)7.30728169
14protein polyglutamylation (GO:0018095)7.29531296
15rRNA methylation (GO:0031167)7.26969902
16multicellular organism reproduction (GO:0032504)7.00084867
17phosphatidylethanolamine metabolic process (GO:0046337)6.90739310
18reproduction (GO:0000003)6.83802702
19binding of sperm to zona pellucida (GO:0007339)6.71026173
20microtubule severing (GO:0051013)6.62252449
21calcium ion-dependent exocytosis (GO:0017156)6.43857122
22protein targeting to Golgi (GO:0000042)6.34412320
23microtubule polymerization or depolymerization (GO:0031109)6.28143394
24axonemal dynein complex assembly (GO:0070286)6.19782849
25rRNA modification (GO:0000154)6.12099041
26establishment of protein localization to Golgi (GO:0072600)6.07327669
27spermatogenesis (GO:0007283)6.04645023
28cell-cell recognition (GO:0009988)6.04386566
29male gamete generation (GO:0048232)6.02567503
30retrograde transport, vesicle recycling within Golgi (GO:0000301)5.92301775
31cellular ketone body metabolic process (GO:0046950)5.72819869
32regulation of cilium movement (GO:0003352)5.67767520
33gamete generation (GO:0007276)5.52060136
34regulation of inclusion body assembly (GO:0090083)5.31336599
35RNA destabilization (GO:0050779)5.09895315
36ketone body metabolic process (GO:1902224)5.05664020
37cell wall macromolecule catabolic process (GO:0016998)4.97949154
38germ cell development (GO:0007281)4.92015069
39motile cilium assembly (GO:0044458)4.88455398
40centriole replication (GO:0007099)4.86754069
41single fertilization (GO:0007338)4.78205114
42cilium or flagellum-dependent cell motility (GO:0001539)4.68621137
43regulation of Rab GTPase activity (GO:0032313)4.68270790
44positive regulation of Rab GTPase activity (GO:0032851)4.68270790
45cell wall macromolecule metabolic process (GO:0044036)4.61993229
46cellular process involved in reproduction in multicellular organism (GO:0022412)4.61725679
47regulation of transcription involved in cell fate commitment (GO:0060850)4.59503708
48chromatin silencing (GO:0006342)4.54168255
49regulation of microtubule-based movement (GO:0060632)4.53441787
50protein localization to Golgi apparatus (GO:0034067)4.51854360
51nucleus organization (GO:0006997)4.47881436
52multicellular organismal reproductive process (GO:0048609)4.47004843
53centriole assembly (GO:0098534)4.45659284
54organic cation transport (GO:0015695)4.26118266
55polyamine biosynthetic process (GO:0006596)4.19775047
56regulation of somitogenesis (GO:0014807)4.17200012
57epithelial cilium movement (GO:0003351)4.07885845
58fertilization (GO:0009566)3.96217673
59nucleosome disassembly (GO:0006337)3.85494356
60protein-DNA complex disassembly (GO:0032986)3.85494356
61regulation of centriole replication (GO:0046599)3.83661105
62response to acidic pH (GO:0010447)3.81174398
63multicellular organismal movement (GO:0050879)3.70221342
64musculoskeletal movement (GO:0050881)3.70221342
65negative regulation of Rho protein signal transduction (GO:0035024)3.64815203
66antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.53612465
67cilium movement (GO:0003341)3.53333128
68cellular response to pH (GO:0071467)3.50745225
69peptidyl-threonine dephosphorylation (GO:0035970)3.48987778
70membrane protein intracellular domain proteolysis (GO:0031293)3.48513909
71coenzyme catabolic process (GO:0009109)3.45090571
72homeostasis of number of cells within a tissue (GO:0048873)3.42192474
73regulation of interleukin-13 production (GO:0032656)3.37829962
74cerebral cortex neuron differentiation (GO:0021895)3.30907924
75regulation of T-helper 2 cell differentiation (GO:0045628)3.28248262
76cranial nerve morphogenesis (GO:0021602)3.22338424
77multicellular organismal development (GO:0007275)3.20834572
78seminiferous tubule development (GO:0072520)3.17685838
79mitochondrial fission (GO:0000266)3.14781781
80glycerol ether metabolic process (GO:0006662)3.13119731
81histone H3-K9 demethylation (GO:0033169)3.10411287
82regulation of phosphoprotein phosphatase activity (GO:0043666)3.08046036
83negative regulation of gene expression, epigenetic (GO:0045814)3.07239332
84cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.05414046
85DNA conformation change (GO:0071103)3.05285468
86protein depolymerization (GO:0051261)2.96769213
87negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.95088552
88RNA localization (GO:0006403)2.94919326
89genitalia morphogenesis (GO:0035112)2.92726830
90mitotic G1 DNA damage checkpoint (GO:0031571)2.90030476
91neurofilament cytoskeleton organization (GO:0060052)2.89778327
92ether metabolic process (GO:0018904)2.88247909
93cell recognition (GO:0008037)2.88211064
94microtubule nucleation (GO:0007020)2.87812441
95tooth mineralization (GO:0034505)2.84731795
96positive regulation of skeletal muscle tissue development (GO:0048643)2.80565753
97negative regulation of histone methylation (GO:0031061)2.74818526
98sperm motility (GO:0030317)12.3842790
99acrosome reaction (GO:0007340)12.1628104
100sperm capacitation (GO:0048240)10.0204909

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.01489509
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.55105721
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.51832873
4TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.33081207
5POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.33081207
6VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.28226332
7ELF1_20517297_ChIP-Seq_JURKAT_Human2.21695543
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.11910907
9EZH2_22144423_ChIP-Seq_EOC_Human2.07121555
10CBP_20019798_ChIP-Seq_JUKART_Human2.02598854
11IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.02598854
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.00569059
13DROSHA_22980978_ChIP-Seq_HELA_Human1.96162435
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.92510355
15CTBP1_25329375_ChIP-Seq_LNCAP_Human1.92509108
16RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.89107768
17EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.88990837
18ERA_21632823_ChIP-Seq_H3396_Human1.88828400
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.88262647
20NANOG_20526341_ChIP-Seq_ESCs_Human1.85161964
21RAC3_21632823_ChIP-Seq_H3396_Human1.84430422
22* CTCF_27219007_Chip-Seq_Bcells_Human1.81826909
23BCL6_27268052_Chip-Seq_Bcells_Human1.77566374
24YY1_22570637_ChIP-Seq_MALME-3M_Human1.75202283
25EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.73216278
26SMC4_20622854_ChIP-Seq_HELA_Human1.72171808
27WDR5_24793694_ChIP-Seq_LNCAP_Human1.71119045
28TDRD3_21172665_ChIP-Seq_MCF-7_Human1.70078028
29STAT6_21828071_ChIP-Seq_BEAS2B_Human1.69737140
30BCOR_27268052_Chip-Seq_Bcells_Human1.67641020
31TAF2_19829295_ChIP-Seq_ESCs_Human1.64643177
32P68_20966046_ChIP-Seq_HELA_Human1.62607679
33E2F1_20622854_ChIP-Seq_HELA_Human1.60670376
34EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.60639828
35PHF8_20622854_ChIP-Seq_HELA_Human1.60606045
36FUS_26573619_Chip-Seq_HEK293_Human1.59880407
37CTCF_20526341_ChIP-Seq_ESCs_Human1.51832263
38* LXR_22292898_ChIP-Seq_THP-1_Human1.49167093
39OCT4_20526341_ChIP-Seq_ESCs_Human1.47418035
40* TP63_22573176_ChIP-Seq_HFKS_Human1.46337671
41ARNT_22903824_ChIP-Seq_MCF-7_Human1.43851127
42UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43280530
43PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.43280244
44MYC_19829295_ChIP-Seq_ESCs_Human1.43117431
45AUTS2_25519132_ChIP-Seq_293T-REX_Human1.42610989
46P300_27268052_Chip-Seq_Bcells_Human1.41847793
47ERG_20517297_ChIP-Seq_VCAP_Human1.40447395
48SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.40016078
49BP1_19119308_ChIP-ChIP_Hs578T_Human1.39231624
50P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.38032967
51SMAD4_21741376_ChIP-Seq_EPCs_Human1.37263056
52AR_25329375_ChIP-Seq_VCAP_Human1.36968720
53ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.36603042
54ER_23166858_ChIP-Seq_MCF-7_Human1.34988267
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32808076
56ETV2_25802403_ChIP-Seq_MESCs_Mouse1.32803443
57SUZ12_27294783_Chip-Seq_ESCs_Mouse1.32714548
58RBPJ_21746931_ChIP-Seq_IB4_Human1.32341049
59EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.31782107
60RUNX1_26923725_Chip-Seq_HPCs_Mouse1.31244075
61SOX2_22085726_ChIP-Seq_NPCs_Mouse1.31041648
62CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.30743568
63SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.30322598
64HNFA_21074721_ChIP-Seq_CACO-2_Human1.30313075
65KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.27419498
66CBX2_22325352_ChIP-Seq_293T-Rex_Human1.27264470
67CEBPB_22108803_ChIP-Seq_LS180_Human1.26152079
68DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.25370363
69TP53_18474530_ChIP-ChIP_U2OS_Human1.23983659
70SMAD3_21741376_ChIP-Seq_ESCs_Human1.23820631
71TP63_19390658_ChIP-ChIP_HaCaT_Human1.22590636
72ETV1_20927104_ChIP-Seq_GIST48_Human1.21503332
73EZH2_27294783_Chip-Seq_ESCs_Mouse1.16481209
74SMRT_27268052_Chip-Seq_Bcells_Human1.15944360
75RUNX_20019798_ChIP-Seq_JUKART_Human1.14188980
76P53_21459846_ChIP-Seq_SAOS-2_Human1.12814120
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.11715842
78GATA3_21878914_ChIP-Seq_MCF-7_Human1.10085420
79NFYB_21822215_ChIP-Seq_K562_Human1.09823077
80ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.07513422
81TBL1_22424771_ChIP-Seq_293T_Human1.07184034
82NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.06937467
83GATA6_21074721_ChIP-Seq_CACO-2_Human1.05147472
84* SA1_27219007_Chip-Seq_Bcells_Human1.04791420
85SMAD4_21741376_ChIP-Seq_HESCs_Human1.04744301
86CSB_26484114_Chip-Seq_FIBROBLAST_Human1.03412543
87P300_19829295_ChIP-Seq_ESCs_Human1.03304017
88PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03274980
89FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01544923
90OCT1_27270436_Chip-Seq_PROSTATE_Human1.01436952
91PHF8_20622853_ChIP-Seq_HELA_Human1.00975715
92CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00062286
93OCT4_19829295_ChIP-Seq_ESCs_Human0.99595585
94KLF5_25053715_ChIP-Seq_YYC3_Human0.98881537
95TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98365293
96KLF4_19829295_ChIP-Seq_ESCs_Human0.97736014
97FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97264958
98GF1_26923725_Chip-Seq_HPCs_Mouse0.97217230
99SOX11_22085726_ChIP-Seq_ESNs_Mouse0.97195209
100RUNX1_27514584_Chip-Seq_MCF-7_Human0.97193965

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose5.39588980
2MP0003878_abnormal_ear_physiology4.87911900
3MP0005377_hearing/vestibular/ear_phenot4.87911900
4MP0003698_abnormal_male_reproductive4.69079029
5MP0001929_abnormal_gametogenesis4.06661381
6MP0001348_abnormal_lacrimal_gland2.90340428
7MP0002161_abnormal_fertility/fecundity2.70533355
8MP0000678_abnormal_parathyroid_gland2.56659553
9MP0003718_maternal_effect2.16267731
10MP0003646_muscle_fatigue2.09422404
11MP0005410_abnormal_fertilization13.0122144
12MP0002210_abnormal_sex_determination1.83291500
13MP0002132_abnormal_respiratory_system1.75987381
14MP0002234_abnormal_pharynx_morphology1.75550276
15MP0003011_delayed_dark_adaptation1.67724978
16MP0005423_abnormal_somatic_nervous1.67245537
17MP0002249_abnormal_larynx_morphology1.63742107
18MP0001145_abnormal_male_reproductive1.52491580
19MP0000653_abnormal_sex_gland1.44785823
20MP0002822_catalepsy1.43652710
21MP0001485_abnormal_pinna_reflex1.40752650
22MP0005310_abnormal_salivary_gland1.40091303
23MP0000534_abnormal_ureter_morphology1.33913271
24MP0009053_abnormal_anal_canal1.33357207
25MP0002282_abnormal_trachea_morphology1.28345820
26MP0005379_endocrine/exocrine_gland_phen1.23066340
27MP0004859_abnormal_synaptic_plasticity1.19466456
28MP0001486_abnormal_startle_reflex1.15282491
29MP0002127_abnormal_cardiovascular_syste1.15256204
30MP0003879_abnormal_hair_cell1.13156690
31MP0001765_abnormal_ion_homeostasis1.08563665
32MP0002138_abnormal_hepatobiliary_system1.06339176
33MP0002735_abnormal_chemical_nociception1.06015670
34MP0005451_abnormal_body_composition1.05345977
35MP0005666_abnormal_adipose_tissue1.01184551
36MP0005395_other_phenotype0.99815044
37MP0004742_abnormal_vestibular_system0.98942715
38MP0009115_abnormal_fat_cell0.98634376
39MP0001963_abnormal_hearing_physiology0.97558820
40MP0000955_abnormal_spinal_cord0.90312577
41MP0000681_abnormal_thyroid_gland0.89907827
42MP0005248_abnormal_Harderian_gland0.88536232
43MP0001968_abnormal_touch/_nociception0.87822562
44MP0002229_neurodegeneration0.87297555
45MP0000026_abnormal_inner_ear0.86445157
46MP0008569_lethality_at_weaning0.85650552
47MP0004510_myositis0.85041449
48MP0005375_adipose_tissue_phenotype0.80946603
49MP0005083_abnormal_biliary_tract0.77758344
50MP0000049_abnormal_middle_ear0.75347132
51MP0001879_abnormal_lymphatic_vessel0.73886677
52MP0002557_abnormal_social/conspecific_i0.71017825
53MP0002067_abnormal_sensory_capabilities0.70141930
54MP0008877_abnormal_DNA_methylation0.68329406
55MP0005551_abnormal_eye_electrophysiolog0.68051891
56MP0001905_abnormal_dopamine_level0.65888790
57MP0000613_abnormal_salivary_gland0.64840506
58MP0001666_abnormal_nutrient_absorption0.61102722
59MP0004085_abnormal_heartbeat0.60384604
60MP0000003_abnormal_adipose_tissue0.59305072
61MP0005636_abnormal_mineral_homeostasis0.58341524
62MP0004484_altered_response_of0.57261779
63MP0003699_abnormal_female_reproductive0.56162894
64MP0003077_abnormal_cell_cycle0.54494694
65MP0005367_renal/urinary_system_phenotyp0.54096521
66MP0000516_abnormal_urinary_system0.54096521
67MP0005647_abnormal_sex_gland0.53352400
68MP0005253_abnormal_eye_physiology0.52615610
69MP0000249_abnormal_blood_vessel0.48977081
70MP0002272_abnormal_nervous_system0.48641363
71MP0002733_abnormal_thermal_nociception0.47221507
72MP0010329_abnormal_lipoprotein_level0.45745029
73MP0001270_distended_abdomen0.45694404
74MP0008961_abnormal_basal_metabolism0.43891035
75MP0003137_abnormal_impulse_conducting0.43871032
76MP0003091_abnormal_cell_migration0.43615912
77MP0002572_abnormal_emotion/affect_behav0.42035270
78MP0004233_abnormal_muscle_weight0.41500741
79MP0001440_abnormal_grooming_behavior0.41300271
80MP0001873_stomach_inflammation0.40553118
81MP0009745_abnormal_behavioral_response0.40267855
82MP0002734_abnormal_mechanical_nocicepti0.39569013
83MP0004036_abnormal_muscle_relaxation0.39411309
84MP0005167_abnormal_blood-brain_barrier0.38996671
85MP0001501_abnormal_sleep_pattern0.38492574
86MP0009697_abnormal_copulation0.38314681
87MP0003631_nervous_system_phenotype0.38171014
88MP0000470_abnormal_stomach_morphology0.37895604
89MP0002928_abnormal_bile_duct0.37881410
90MP0000566_synostosis0.37092546
91MP0005084_abnormal_gallbladder_morpholo0.36535707
92MP0003936_abnormal_reproductive_system0.35908108
93MP0000467_abnormal_esophagus_morphology0.35517923
94MP0005535_abnormal_body_temperature0.34927730
95MP0003119_abnormal_digestive_system0.34915082
96MP0003959_abnormal_lean_body0.32815994
97MP0005623_abnormal_meninges_morphology0.32506056
98MP0005166_decreased_susceptibility_to0.32502599
99MP0003632_abnormal_nervous_system0.32254452
100MP0001970_abnormal_pain_threshold0.31518246

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)8.06477545
2Dynein arm defect of respiratory motile cilia (HP:0012255)5.86950137
3Absent/shortened dynein arms (HP:0200106)5.86950137
4Tubulointerstitial nephritis (HP:0001970)5.55246109
5Hyperkalemia (HP:0002153)5.18887011
6Chronic hepatic failure (HP:0100626)5.06560849
7Bony spicule pigmentary retinopathy (HP:0007737)4.84952998
8Asymmetric septal hypertrophy (HP:0001670)4.83018174
9Resting tremor (HP:0002322)4.77587625
10Attenuation of retinal blood vessels (HP:0007843)4.75819296
11Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.60306501
12Abnormal ciliary motility (HP:0012262)4.48317999
13Abnormal respiratory motile cilium physiology (HP:0012261)4.46072634
14Infertility (HP:0000789)4.35582579
15Abnormal respiratory epithelium morphology (HP:0012253)4.33049595
16Abnormal respiratory motile cilium morphology (HP:0005938)4.33049595
17Nasal polyposis (HP:0100582)4.28634862
18Abnormality of macular pigmentation (HP:0008002)4.23684082
19Male infertility (HP:0003251)4.13753254
20Facial shape deformation (HP:0011334)4.10332249
21Potter facies (HP:0002009)4.10332249
22Bell-shaped thorax (HP:0001591)4.00121663
23Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.95606478
24Cone-rod dystrophy (HP:0000548)3.89235047
25Abnormal rod and cone electroretinograms (HP:0008323)3.80942634
26Hypoalphalipoproteinemia (HP:0003233)3.55604193
27Hypoplasia of the thymus (HP:0000778)3.51616836
28Abnormality of the nasal mucosa (HP:0000433)3.48765526
29Impulsivity (HP:0100710)3.41041482
30Aplasia/Hypoplasia of the earlobes (HP:0009906)3.39682866
31Azoospermia (HP:0000027)3.38838387
32Progressive sensorineural hearing impairment (HP:0000408)3.36041708
33Abnormal spermatogenesis (HP:0008669)3.32368086
34Unilateral renal agenesis (HP:0000122)3.23405845
35Postural instability (HP:0002172)3.20169509
36Hypoplastic ischia (HP:0003175)3.12867698
37Double outlet right ventricle (HP:0001719)3.11079310
38Congenital malformation of the right heart (HP:0011723)3.11079310
39Abnormality of the aortic arch (HP:0012303)3.03528041
40Menstrual irregularities (HP:0000858)3.03031384
41Enlarged epiphyses (HP:0010580)3.01458328
42Truncal obesity (HP:0001956)2.96366996
43Renovascular hypertension (HP:0100817)2.95277746
44Abnormal urine output (HP:0012590)2.91147375
45Renal dysplasia (HP:0000110)2.84927050
46Abnormality of potassium homeostasis (HP:0011042)2.83140103
47Abnormality of the ischium (HP:0003174)2.81489400
48Rhinitis (HP:0012384)2.75907553
49Amelogenesis imperfecta (HP:0000705)2.75016122
50Generalized aminoaciduria (HP:0002909)2.72061714
51Insulin-resistant diabetes mellitus (HP:0000831)2.71256620
52Progressive cerebellar ataxia (HP:0002073)2.60172308
53Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.60091709
54Tetany (HP:0001281)2.58847015
55Abnormality of the parathyroid morphology (HP:0011766)2.53618358
56Polydipsia (HP:0001959)2.51913674
57Abnormal drinking behavior (HP:0030082)2.51913674
58Portal hypertension (HP:0001409)2.51164582
59Abnormality of renal excretion (HP:0011036)2.50854560
60Tubulointerstitial abnormality (HP:0001969)2.47285474
61Nephronophthisis (HP:0000090)2.46050634
62Stage 5 chronic kidney disease (HP:0003774)2.42140683
63Hyperuricemia (HP:0002149)2.39905558
64Increased purine levels (HP:0004368)2.39905558
65Abnormality of the costochondral junction (HP:0000919)2.39617096
66Polyuria (HP:0000103)2.30855389
67Abnormality of the hepatic vasculature (HP:0006707)2.29455051
68Flattened epiphyses (HP:0003071)2.27458877
69Abnormality of dental color (HP:0011073)2.27036775
70Ventricular tachycardia (HP:0004756)2.26531970
71Myokymia (HP:0002411)2.23917759
72Progressive hearing impairment (HP:0001730)2.11705330
73Abnormality of the renal medulla (HP:0100957)2.07500936
74Osteomalacia (HP:0002749)2.05550825
75Hyponatremia (HP:0002902)2.00623923
76Abnormal connection of the cardiac segments (HP:0011545)2.00308156
77Abnormal ventriculo-arterial connection (HP:0011563)2.00308156
78Transposition of the great arteries (HP:0001669)2.00308156
79Bronchiectasis (HP:0002110)2.00249287
80Chronic bronchitis (HP:0004469)1.98600266
81Recurrent pneumonia (HP:0006532)1.97289402
82Aplasia/Hypoplasia of the sacrum (HP:0008517)1.95406381
83Widely patent fontanelles and sutures (HP:0004492)1.94826436
84Hyperthyroidism (HP:0000836)1.94558662
85Abnormality of the epiphysis of the femoral head (HP:0010574)1.89076718
86Epiphyseal dysplasia (HP:0002656)1.88865605
87Subcapsular cataract (HP:0000523)1.88335085
88Hypophosphatemic rickets (HP:0004912)1.87864472
89Renal Fanconi syndrome (HP:0001994)1.84933794
90Bradycardia (HP:0001662)1.84119675
91Abnormality of chloride homeostasis (HP:0011422)1.84101472
92Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.83342642
93Absent epiphyses (HP:0010577)1.83342642
94Amblyopia (HP:0000646)1.80797298
95Optic nerve hypoplasia (HP:0000609)1.80636327
96Hypoparathyroidism (HP:0000829)1.80613121
97Neoplasm of the heart (HP:0100544)1.77521641
98Recurrent corneal erosions (HP:0000495)1.77455972
99Abnormality of femoral epiphyses (HP:0006499)1.74970875
100Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.74970875

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK47.59531696
2TESK16.86770977
3DDR24.25378011
4STK384.21963466
5PNCK3.50212300
6PRKD33.01381365
7MAP4K22.94534881
8MAPK152.92194472
9BRD42.90697575
10STK38L2.76155151
11PLK22.68910364
12CAMK1G2.65413668
13INSRR2.51818494
14MST1R1.91097668
15PDPK11.83578836
16DYRK1B1.69950939
17PDK11.66483526
18NEK61.54114677
19CDK121.46235439
20WNK11.45719019
21PIK3CG1.27454087
22CDK71.26356577
23AKT31.26010750
24WNK41.12047819
25KSR21.11765223
26PTK2B1.01107694
27MAP3K90.99781269
28SIK20.95562196
29CAMK1D0.92362484
30STK390.88830065
31BRAF0.80246692
32LATS20.76542101
33MAP3K110.76302544
34MAP3K20.75519301
35RIPK40.74279469
36MAP2K20.73954692
37UHMK10.69743937
38RPS6KA10.69587441
39TYRO30.69330772
40RPS6KA20.66021747
41PRKG10.63414848
42SGK2230.63027713
43SGK4940.63027713
44MAP3K80.61086949
45CAMK10.60829474
46PRKG20.59635248
47ROCK10.59220489
48LATS10.52895418
49GSK3B0.52176205
50PRKAA20.50497196
51CDK20.49931019
52MTOR0.48415095
53CDK30.45709812
54CDK40.45535855
55MAP3K10.45154556
56MAPK80.44430030
57CDK10.44228015
58MAPK10.43833814
59TESK20.43734467
60BMPR1B0.42229748
61SGK10.38647720
62CAMK40.35992422
63PRKCZ0.35075170
64RPS6KL10.34387285
65RPS6KC10.34387285
66MET0.31380167
67RPS6KA60.31373887
68CHEK10.30184172
69MARK10.29135578
70MAPK140.28066473
71ARAF0.27914588
72PRKCG0.26588366
73MAPK100.25785906
74PRKCB0.23473127
75MINK10.23453096
76PINK10.22744566
77NTRK30.21815095
78MUSK0.19030861
79NEK20.19015641
80FER0.18384196
81MARK20.18162674
82AKT10.16922637
83ACVR1B0.15000206
84BRSK10.14661991
85OXSR10.14513844
86TIE10.14184566
87PKN10.13825639
88SGK20.13490540
89MAPK110.13066789
90TLK10.10733345
91PRKAA10.10029259
92PRKACB0.09077533
93TNIK0.08416111
94MAP3K40.08274949
95PRKACA0.07019114
96MAPK90.06889161
97SGK30.06726545
98ZAK0.06204866
99RIPK10.06181939
100VRK10.06086993

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000617.88580689
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.76559645
3Olfactory transduction_Homo sapiens_hsa047402.96667167
4Butanoate metabolism_Homo sapiens_hsa006502.55942586
5Fatty acid degradation_Homo sapiens_hsa000712.20141967
6Glycerophospholipid metabolism_Homo sapiens_hsa005642.15079995
7Fatty acid metabolism_Homo sapiens_hsa012122.02057142
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.82302963
9Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.78054448
10Dorso-ventral axis formation_Homo sapiens_hsa043201.76035233
11Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.72149858
12Adipocytokine signaling pathway_Homo sapiens_hsa049201.54211950
13Type II diabetes mellitus_Homo sapiens_hsa049301.48934343
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.47580507
15Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.47276628
16Taste transduction_Homo sapiens_hsa047421.41190623
17Phenylalanine metabolism_Homo sapiens_hsa003601.38646820
18Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.33744596
19RNA transport_Homo sapiens_hsa030131.31456031
20PPAR signaling pathway_Homo sapiens_hsa033201.30482163
21Type I diabetes mellitus_Homo sapiens_hsa049401.18970939
22Arginine and proline metabolism_Homo sapiens_hsa003301.16454527
23Antigen processing and presentation_Homo sapiens_hsa046121.11075071
24Endocytosis_Homo sapiens_hsa041441.10322573
25Allograft rejection_Homo sapiens_hsa053301.03651260
26Phototransduction_Homo sapiens_hsa047441.03158597
27Arginine biosynthesis_Homo sapiens_hsa002201.01925622
28Autoimmune thyroid disease_Homo sapiens_hsa053201.01307522
29Salivary secretion_Homo sapiens_hsa049700.96138452
30Graft-versus-host disease_Homo sapiens_hsa053320.91922874
31Hedgehog signaling pathway_Homo sapiens_hsa043400.89188080
32Morphine addiction_Homo sapiens_hsa050320.88873109
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.85288482
34Inositol phosphate metabolism_Homo sapiens_hsa005620.83685120
35Protein digestion and absorption_Homo sapiens_hsa049740.83611668
36Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.83583374
37Renin-angiotensin system_Homo sapiens_hsa046140.77896547
38Viral myocarditis_Homo sapiens_hsa054160.77866879
39Circadian entrainment_Homo sapiens_hsa047130.77688431
40Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77055608
41cAMP signaling pathway_Homo sapiens_hsa040240.76261971
42Synaptic vesicle cycle_Homo sapiens_hsa047210.75335935
43Calcium signaling pathway_Homo sapiens_hsa040200.74607771
44Estrogen signaling pathway_Homo sapiens_hsa049150.69727385
45Fat digestion and absorption_Homo sapiens_hsa049750.68437036
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68020066
47Glycerolipid metabolism_Homo sapiens_hsa005610.67632107
48Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65390687
49Oocyte meiosis_Homo sapiens_hsa041140.64885549
50Tight junction_Homo sapiens_hsa045300.64763203
51Tyrosine metabolism_Homo sapiens_hsa003500.62923091
52Influenza A_Homo sapiens_hsa051640.60352449
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.59913030
54Selenocompound metabolism_Homo sapiens_hsa004500.59851249
55Cardiac muscle contraction_Homo sapiens_hsa042600.59682705
56Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59465099
57ABC transporters_Homo sapiens_hsa020100.58423406
58Aldosterone synthesis and secretion_Homo sapiens_hsa049250.53931445
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.52629637
60Biosynthesis of amino acids_Homo sapiens_hsa012300.51159183
61Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.50952500
62Nicotine addiction_Homo sapiens_hsa050330.48729224
63Maturity onset diabetes of the young_Homo sapiens_hsa049500.48604508
64Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48518203
65MAPK signaling pathway_Homo sapiens_hsa040100.48073494
66Glutamatergic synapse_Homo sapiens_hsa047240.46159388
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44398364
68Purine metabolism_Homo sapiens_hsa002300.44376534
69Acute myeloid leukemia_Homo sapiens_hsa052210.42734018
70Renin secretion_Homo sapiens_hsa049240.41937564
71VEGF signaling pathway_Homo sapiens_hsa043700.41172414
72Gastric acid secretion_Homo sapiens_hsa049710.40579205
73Retinol metabolism_Homo sapiens_hsa008300.37735235
74Bile secretion_Homo sapiens_hsa049760.37466579
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.37110620
76Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36262313
77Serotonergic synapse_Homo sapiens_hsa047260.34864525
78Insulin secretion_Homo sapiens_hsa049110.34499000
79Viral carcinogenesis_Homo sapiens_hsa052030.33135575
80Cholinergic synapse_Homo sapiens_hsa047250.31277622
81Alcoholism_Homo sapiens_hsa050340.30955003
82Nitrogen metabolism_Homo sapiens_hsa009100.28341804
83Basal transcription factors_Homo sapiens_hsa030220.26712693
84Pancreatic secretion_Homo sapiens_hsa049720.26545231
85GABAergic synapse_Homo sapiens_hsa047270.24636202
86cGMP-PKG signaling pathway_Homo sapiens_hsa040220.23340792
87Vitamin B6 metabolism_Homo sapiens_hsa007500.23259276
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.23141550
89Long-term potentiation_Homo sapiens_hsa047200.22911070
90Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.20127761
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.19491278
92Adherens junction_Homo sapiens_hsa045200.19160214
93Prolactin signaling pathway_Homo sapiens_hsa049170.17895615
94Oxytocin signaling pathway_Homo sapiens_hsa049210.17276228
95Carbon metabolism_Homo sapiens_hsa012000.17270020
96Jak-STAT signaling pathway_Homo sapiens_hsa046300.16615768
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.15861039
98Legionellosis_Homo sapiens_hsa051340.15553991
99mRNA surveillance pathway_Homo sapiens_hsa030150.14943156
100Metabolic pathways_Homo sapiens_hsa011000.13948757

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