ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	axonemal dynein complex assembly (GO:0070286)	7.94400276
2	epithelial cilium movement (GO:0003351)	7.15619837
3	cilium movement (GO:0003341)	7.14818811
4	cilium or flagellum-dependent cell motility (GO:0001539)	6.70303103
5	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	6.69412663
6	axoneme assembly (GO:0035082)	5.59566253
7	motile cilium assembly (GO:0044458)	5.37159189
8	behavioral response to nicotine (GO:0035095)	4.92201475
9	regulation of cilium movement (GO:0003352)	4.38783453
10	protein polyglutamylation (GO:0018095)	3.82216627
11	intraciliary transport (GO:0042073)	3.77336284
12	indole-containing compound catabolic process (GO:0042436)	3.75698449
13	indolalkylamine catabolic process (GO:0046218)	3.75698449
14	tryptophan catabolic process (GO:0006569)	3.75698449
15	cilium organization (GO:0044782)	3.67766196
16	water-soluble vitamin biosynthetic process (GO:0042364)	3.62664131
17	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.61268622
18	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.61268622
19	NADH dehydrogenase complex assembly (GO:0010257)	3.61268622
20	cell proliferation in forebrain (GO:0021846)	3.60772548
21	indolalkylamine metabolic process (GO:0006586)	3.59961015
22	regulation of collateral sprouting (GO:0048670)	3.58723786
23	cilium assembly (GO:0042384)	3.51769546
24	protein complex biogenesis (GO:0070271)	3.50038663
25	protein localization to cilium (GO:0061512)	3.47716236
26	kynurenine metabolic process (GO:0070189)	3.46081809
27	cilium morphogenesis (GO:0060271)	3.41831455
28	sulfation (GO:0051923)	3.37068956
29	left/right pattern formation (GO:0060972)	3.29841956
30	centriole replication (GO:0007099)	3.25736297
31	piRNA metabolic process (GO:0034587)	3.21496244
32	left/right axis specification (GO:0070986)	3.18533370
33	mitochondrial respiratory chain complex assembly (GO:0033108)	3.15141673
34	cellular response to ATP (GO:0071318)	3.13912631
35	DNA deamination (GO:0045006)	3.10254819
36	sperm motility (GO:0030317)	3.09211516
37	cornea development in camera-type eye (GO:0061303)	3.07890311
38	thyroid hormone metabolic process (GO:0042403)	3.07225192
39	negative regulation of T cell differentiation in thymus (GO:0033085)	2.99723396
40	microtubule bundle formation (GO:0001578)	2.98668549
41	tryptophan metabolic process (GO:0006568)	2.96436474
42	indole-containing compound metabolic process (GO:0042430)	2.96073268
43	centriole assembly (GO:0098534)	2.92040355
44	preassembly of GPI anchor in ER membrane (GO:0016254)	2.91384478
45	somite development (GO:0061053)	2.91030138
46	transmission of nerve impulse (GO:0019226)	2.90745118
47	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.89951046
48	serotonin metabolic process (GO:0042428)	2.88433888
49	photoreceptor cell development (GO:0042461)	2.87993244
50	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.87397788
51	reflex (GO:0060004)	2.85956851
52	L-fucose metabolic process (GO:0042354)	2.83343928
53	L-fucose catabolic process (GO:0042355)	2.83343928
54	fucose catabolic process (GO:0019317)	2.83343928
55	gamma-aminobutyric acid transport (GO:0015812)	2.82147779
56	ventricular system development (GO:0021591)	2.81384424
57	negative regulation of telomere maintenance (GO:0032205)	2.79381868
58	cellular component assembly involved in morphogenesis (GO:0010927)	2.78837065
59	regulation of hippo signaling (GO:0035330)	2.78412092
60	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.77059549
61	DNA methylation involved in gamete generation (GO:0043046)	2.76933347
62	photoreceptor cell maintenance (GO:0045494)	2.76079424
63	amine catabolic process (GO:0009310)	2.69114344
64	cellular biogenic amine catabolic process (GO:0042402)	2.69114344
65	nonmotile primary cilium assembly (GO:0035058)	2.67125241
66	retinal cone cell development (GO:0046549)	2.66751606
67	neurofilament cytoskeleton organization (GO:0060052)	2.66484536
68	otic vesicle formation (GO:0030916)	2.65592935
69	regulation of microtubule-based movement (GO:0060632)	2.64577942
70	determination of left/right symmetry (GO:0007368)	2.64505801
71	detection of light stimulus involved in visual perception (GO:0050908)	2.64181040
72	detection of light stimulus involved in sensory perception (GO:0050962)	2.64181040
73	regulation of glomerulus development (GO:0090192)	2.63805602
74	drug catabolic process (GO:0042737)	2.62386431
75	benzene-containing compound metabolic process (GO:0042537)	2.61804218
76	eye photoreceptor cell development (GO:0042462)	2.61693129
77	primary amino compound metabolic process (GO:1901160)	2.60793288
78	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.60316024
79	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.58872823
80	adaptation of signaling pathway (GO:0023058)	2.56729075
81	exogenous drug catabolic process (GO:0042738)	2.56468378
82	thyroid hormone generation (GO:0006590)	2.56427486
83	smoothened signaling pathway (GO:0007224)	2.56200494
84	regulation of action potential (GO:0098900)	2.56081110
85	male meiosis I (GO:0007141)	2.55940039
86	limb bud formation (GO:0060174)	2.53771544
87	negative regulation of systemic arterial blood pressure (GO:0003085)	2.53148240
88	negative regulation of response to food (GO:0032096)	2.49511929
89	negative regulation of appetite (GO:0032099)	2.49511929
90	chaperone-mediated protein transport (GO:0072321)	2.48092662
91	regulation of neurotransmitter uptake (GO:0051580)	2.48078290
92	appendage development (GO:0048736)	2.46935955
93	limb development (GO:0060173)	2.46935955
94	synapsis (GO:0007129)	2.46692827
95	N-acetylglucosamine metabolic process (GO:0006044)	2.46595552
96	determination of bilateral symmetry (GO:0009855)	2.45377010
97	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.44068576
98	male meiosis (GO:0007140)	2.43839655
99	neuronal action potential (GO:0019228)	2.42273494
100	pharyngeal system development (GO:0060037)	2.42133553

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.57653214
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.05114536
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.01155066
4	VDR_22108803_ChIP-Seq_LS180_Human	2.90373905
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.68850181
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.42554987
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.39760835
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.24573537
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.21849424
10	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.07623661
11	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.05034048
12	EWS_26573619_Chip-Seq_HEK293_Human	1.92726157
13	FUS_26573619_Chip-Seq_HEK293_Human	1.85836621
14	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.80918138
15	ER_23166858_ChIP-Seq_MCF-7_Human	1.80255038
16	* P300_19829295_ChIP-Seq_ESCs_Human	1.78745159
17	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.73429843
18	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.69296123
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.69288880
20	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.68647644
21	IRF1_19129219_ChIP-ChIP_H3396_Human	1.62253969
22	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.61529267
23	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.58990754
24	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.58933224
25	SMAD4_21799915_ChIP-Seq_A2780_Human	1.57422054
26	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.56285557
27	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.55964056
28	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.55820301
29	TAF15_26573619_Chip-Seq_HEK293_Human	1.55024341
30	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.53138422
31	BCAT_22108803_ChIP-Seq_LS180_Human	1.52166731
32	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.51357374
33	CBP_20019798_ChIP-Seq_JUKART_Human	1.51357374
34	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.50781696
35	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.50600228
36	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.45883461
37	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.44963305
38	STAT3_23295773_ChIP-Seq_U87_Human	1.43574005
39	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.42649789
40	AR_25329375_ChIP-Seq_VCAP_Human	1.39471762
41	RNF2_27304074_Chip-Seq_NSC_Mouse	1.39396849
42	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.38736354
43	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.38339213
44	TCF4_23295773_ChIP-Seq_U87_Human	1.35225576
45	REST_21632747_ChIP-Seq_MESCs_Mouse	1.34872931
46	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.32987453
47	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.32987453
48	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.32299402
49	MYC_18940864_ChIP-ChIP_HL60_Human	1.31252761
50	DROSHA_22980978_ChIP-Seq_HELA_Human	1.29502601
51	TP53_22573176_ChIP-Seq_HFKS_Human	1.29307508
52	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.29136772
53	TCF4_22108803_ChIP-Seq_LS180_Human	1.25896006
54	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.23948185
55	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.23849698
56	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.23849698
57	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.23738577
58	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.23617613
59	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.23428171
60	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.22627150
61	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.22529073
62	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.20639652
63	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.20301392
64	RUNX2_22187159_ChIP-Seq_PCA_Human	1.19766803
65	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.19165258
66	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.19104120
67	NCOR_22424771_ChIP-Seq_293T_Human	1.18711723
68	SOX2_19829295_ChIP-Seq_ESCs_Human	1.18416906
69	NANOG_19829295_ChIP-Seq_ESCs_Human	1.18416906
70	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.17786899
71	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.17596737
72	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.17555682
73	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.16883148
74	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.16296850
75	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.15632236
76	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.15120438
77	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.13718148
78	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.12284161
79	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.10563417
80	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.10361812
81	ETV1_20927104_ChIP-Seq_GIST48_Human	1.09702315
82	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.07867963
83	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.07596515
84	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.06161543
85	AR_20517297_ChIP-Seq_VCAP_Human	1.05855354
86	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.05611663
87	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.05242994
88	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.04569397
89	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.03956598
90	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.03890215
91	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.03773172
92	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.02911530
93	HOXB7_26014856_ChIP-Seq_BT474_Human	1.02437038
94	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.02004738
95	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.01408453
96	P53_22387025_ChIP-Seq_ESCs_Mouse	1.00658626
97	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.00472808
98	RBPJ_21746931_ChIP-Seq_IB4_Human	0.96864763
99	* PHF8_20622853_ChIP-Seq_HELA_Human	0.96741272
100	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.95798469

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.17859807
2	MP0001485_abnormal_pinna_reflex	2.47566374
3	MP0008875_abnormal_xenobiotic_pharmacok	2.41652375
4	MP0002876_abnormal_thyroid_physiology	2.41279062
5	MP0005646_abnormal_pituitary_gland	2.38346357
6	MP0005551_abnormal_eye_electrophysiolog	2.37917555
7	MP0004885_abnormal_endolymph	2.29828375
8	MP0008877_abnormal_DNA_methylation	2.26062404
9	MP0002653_abnormal_ependyma_morphology	2.24691130
10	MP0002837_dystrophic_cardiac_calcinosis	2.19611797
11	MP0004133_heterotaxia	2.18424846
12	MP0009046_muscle_twitch	1.95472800
13	MP0002160_abnormal_reproductive_system	1.91783506
14	MP0003195_calcinosis	1.91713525
15	MP0000372_irregular_coat_pigmentation	1.81621442
16	MP0003646_muscle_fatigue	1.81585732
17	MP0004043_abnormal_pH_regulation	1.76389601
18	MP0001984_abnormal_olfaction	1.76296955
19	MP0000631_abnormal_neuroendocrine_gland	1.75900644
20	MP0008872_abnormal_physiological_respon	1.73540341
21	MP0000049_abnormal_middle_ear	1.71297371
22	MP0002277_abnormal_respiratory_mucosa	1.69988448
23	MP0002938_white_spotting	1.69390651
24	MP0006072_abnormal_retinal_apoptosis	1.67398577
25	MP0005389_reproductive_system_phenotype	1.63213008
26	MP0002138_abnormal_hepatobiliary_system	1.62089204
27	MP0004142_abnormal_muscle_tone	1.59979536
28	MP0001968_abnormal_touch/_nociception	1.59400732
29	MP0009745_abnormal_behavioral_response	1.56364642
30	MP0008995_early_reproductive_senescence	1.55444041
31	MP0005377_hearing/vestibular/ear_phenot	1.52921350
32	MP0003878_abnormal_ear_physiology	1.52921350
33	MP0005253_abnormal_eye_physiology	1.50700054
34	MP0002272_abnormal_nervous_system	1.48733344
35	MP0006276_abnormal_autonomic_nervous	1.48631623
36	MP0002102_abnormal_ear_morphology	1.43837951
37	MP0003136_yellow_coat_color	1.43247740
38	MP0000569_abnormal_digit_pigmentation	1.39296471
39	MP0005670_abnormal_white_adipose	1.38533831
40	MP0002736_abnormal_nociception_after	1.35618066
41	MP0008789_abnormal_olfactory_epithelium	1.35253870
42	MP0003880_abnormal_central_pattern	1.27695400
43	MP0001486_abnormal_startle_reflex	1.27328655
44	MP0002734_abnormal_mechanical_nocicepti	1.25350371
45	MP0001529_abnormal_vocalization	1.24563787
46	MP0004742_abnormal_vestibular_system	1.22869338
47	MP0005084_abnormal_gallbladder_morpholo	1.20717116
48	MP0003938_abnormal_ear_development	1.18276619
49	MP0002282_abnormal_trachea_morphology	1.18159928
50	MP0005174_abnormal_tail_pigmentation	1.16438613
51	MP0000026_abnormal_inner_ear	1.16159671
52	MP0002735_abnormal_chemical_nociception	1.16010290
53	MP0005195_abnormal_posterior_eye	1.14990781
54	MP0002163_abnormal_gland_morphology	1.14219705
55	MP0001963_abnormal_hearing_physiology	1.12930879
56	MP0004145_abnormal_muscle_electrophysio	1.10416625
57	MP0005083_abnormal_biliary_tract	1.08870288
58	MP0004134_abnormal_chest_morphology	1.08232572
59	MP0002064_seizures	1.08218669
60	MP0001970_abnormal_pain_threshold	1.06370619
61	MP0001986_abnormal_taste_sensitivity	1.06265059
62	MP0002638_abnormal_pupillary_reflex	1.05750711
63	MP0003937_abnormal_limbs/digits/tail_de	1.04685593
64	MP0002557_abnormal_social/conspecific_i	1.04254640
65	MP0001919_abnormal_reproductive_system	1.03145599
66	MP0002572_abnormal_emotion/affect_behav	1.01691060
67	MP0001501_abnormal_sleep_pattern	1.01164885
68	MP0009780_abnormal_chondrocyte_physiolo	0.99305281
69	MP0003698_abnormal_male_reproductive	0.98988281
70	MP0002928_abnormal_bile_duct	0.97866637
71	MP0002210_abnormal_sex_determination	0.95595498
72	MP0003252_abnormal_bile_duct	0.95129603
73	MP0002752_abnormal_somatic_nervous	0.94775584
74	MP0000383_abnormal_hair_follicle	0.94354839
75	MP0005379_endocrine/exocrine_gland_phen	0.93779680
76	MP0002909_abnormal_adrenal_gland	0.93466041
77	MP0003011_delayed_dark_adaptation	0.91304733
78	MP0001905_abnormal_dopamine_level	0.91108222
79	MP0000613_abnormal_salivary_gland	0.89632967
80	MP0000427_abnormal_hair_cycle	0.87703262
81	MP0003787_abnormal_imprinting	0.87290139
82	MP0002067_abnormal_sensory_capabilities	0.87264337
83	MP0001440_abnormal_grooming_behavior	0.87044540
84	MP0002733_abnormal_thermal_nociception	0.86587940
85	MP0001929_abnormal_gametogenesis	0.86572173
86	MP0002132_abnormal_respiratory_system	0.86162995
87	MP0003718_maternal_effect	0.84758980
88	MP0002184_abnormal_innervation	0.83648244
89	MP0004019_abnormal_vitamin_homeostasis	0.83367256
90	MP0000653_abnormal_sex_gland	0.82489855
91	MP0003119_abnormal_digestive_system	0.82311867
92	MP0000230_abnormal_systemic_arterial	0.80903510
93	MP0001145_abnormal_male_reproductive	0.80422312
94	MP0003635_abnormal_synaptic_transmissio	0.78677609
95	MP0001502_abnormal_circadian_rhythm	0.78011300
96	MP0004130_abnormal_muscle_cell	0.78000558
97	MP0001293_anophthalmia	0.76994843
98	MP0005410_abnormal_fertilization	0.76920340
99	MP0002063_abnormal_learning/memory/cond	0.76769018
100	MP0002095_abnormal_skin_pigmentation	0.76385913

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal ciliary motility (HP:0012262)	5.96233288
2	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.86361400
3	Absent/shortened dynein arms (HP:0200106)	5.86361400
4	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	5.84711344
5	Abnormal respiratory motile cilium physiology (HP:0012261)	5.82645283
6	Abnormal respiratory epithelium morphology (HP:0012253)	5.79098518
7	Abnormal respiratory motile cilium morphology (HP:0005938)	5.79098518
8	Rhinitis (HP:0012384)	4.92735872
9	True hermaphroditism (HP:0010459)	4.72468054
10	Pancreatic fibrosis (HP:0100732)	4.70913531
11	Pancreatic cysts (HP:0001737)	4.50948287
12	Abnormality of midbrain morphology (HP:0002418)	3.98390857
13	Molar tooth sign on MRI (HP:0002419)	3.98390857
14	Nephronophthisis (HP:0000090)	3.83006145
15	Chronic bronchitis (HP:0004469)	3.66471314
16	Bronchiectasis (HP:0002110)	3.54985608
17	Cystic liver disease (HP:0006706)	3.25750613
18	Abnormality of the renal medulla (HP:0100957)	3.19488262
19	Chronic hepatic failure (HP:0100626)	3.14023404
20	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.95416589
21	Congenital stationary night blindness (HP:0007642)	2.89663536
22	Medial flaring of the eyebrow (HP:0010747)	2.81395082
23	Male pseudohermaphroditism (HP:0000037)	2.74340468
24	Pendular nystagmus (HP:0012043)	2.68672150
25	Abnormality of the renal cortex (HP:0011035)	2.66018104
26	Abolished electroretinogram (ERG) (HP:0000550)	2.64860743
27	Postaxial foot polydactyly (HP:0001830)	2.64754720
28	Sclerocornea (HP:0000647)	2.62885517
29	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.60081290
30	Abnormality of the renal collecting system (HP:0004742)	2.59230008
31	Congenital hepatic fibrosis (HP:0002612)	2.52899558
32	Abnormal rod and cone electroretinograms (HP:0008323)	2.51506562
33	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.50010520
34	Furrowed tongue (HP:0000221)	2.43301288
35	Asplenia (HP:0001746)	2.42617290
36	Anencephaly (HP:0002323)	2.42248667
37	Tubular atrophy (HP:0000092)	2.41816752
38	Acute necrotizing encephalopathy (HP:0006965)	2.37164638
39	Occipital encephalocele (HP:0002085)	2.35320346
40	Decreased central vision (HP:0007663)	2.34002300
41	Progressive cerebellar ataxia (HP:0002073)	2.30128031
42	Genetic anticipation (HP:0003743)	2.29852058
43	Gait imbalance (HP:0002141)	2.27516146
44	Congenital primary aphakia (HP:0007707)	2.26247863
45	Congenital sensorineural hearing impairment (HP:0008527)	2.18871532
46	Duplicated collecting system (HP:0000081)	2.16756208
47	Congenital, generalized hypertrichosis (HP:0004540)	2.15197382
48	Methylmalonic acidemia (HP:0002912)	2.14349903
49	Chronic sinusitis (HP:0011109)	2.12706827
50	Decreased circulating renin level (HP:0003351)	2.12028125
51	Absent thumb (HP:0009777)	2.11957392
52	Nasal polyposis (HP:0100582)	2.10824081
53	Nephrogenic diabetes insipidus (HP:0009806)	2.09664130
54	Acute encephalopathy (HP:0006846)	2.08440499
55	Ectopic kidney (HP:0000086)	2.07630830
56	Abnormality of DNA repair (HP:0003254)	2.06306619
57	Infertility (HP:0000789)	2.04100475
58	Mitochondrial inheritance (HP:0001427)	2.03510263
59	Genital tract atresia (HP:0001827)	2.02899997
60	Progressive macrocephaly (HP:0004481)	1.99562117
61	Vaginal atresia (HP:0000148)	1.99281784
62	Abnormal mitochondria in muscle tissue (HP:0008316)	1.95699066
63	Postaxial hand polydactyly (HP:0001162)	1.94019538
64	Increased corneal curvature (HP:0100692)	1.93843166
65	Keratoconus (HP:0000563)	1.93843166
66	Preaxial hand polydactyly (HP:0001177)	1.92440658
67	Bony spicule pigmentary retinopathy (HP:0007737)	1.91968883
68	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	1.91591309
69	Short 1st metacarpal (HP:0010034)	1.91591309
70	Tubulointerstitial nephritis (HP:0001970)	1.90797246
71	Carpal bone hypoplasia (HP:0001498)	1.87938981
72	Abnormality of the middle phalanges of the toes (HP:0010183)	1.83330134
73	Attenuation of retinal blood vessels (HP:0007843)	1.82637765
74	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.82558502
75	Hypoplasia of the uterus (HP:0000013)	1.78881805
76	Increased CSF lactate (HP:0002490)	1.78753823
77	Severe visual impairment (HP:0001141)	1.76878742
78	Renal cortical cysts (HP:0000803)	1.76522880
79	Gaze-evoked nystagmus (HP:0000640)	1.73160943
80	Methylmalonic aciduria (HP:0012120)	1.72612043
81	Abnormal drinking behavior (HP:0030082)	1.72380912
82	Polydipsia (HP:0001959)	1.72380912
83	Bronchitis (HP:0012387)	1.70325704
84	Median cleft lip (HP:0000161)	1.70084162
85	3-Methylglutaconic aciduria (HP:0003535)	1.69611513
86	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.67798655
87	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.67385694
88	Abnormality of the 1st metacarpal (HP:0010009)	1.67070655
89	Septo-optic dysplasia (HP:0100842)	1.66130357
90	Agitation (HP:0000713)	1.65928145
91	Hyperventilation (HP:0002883)	1.65640432
92	Short hallux (HP:0010109)	1.64107500
93	Aganglionic megacolon (HP:0002251)	1.61411722
94	Aplasia/hypoplasia of the uterus (HP:0008684)	1.61221682
95	Poor coordination (HP:0002370)	1.60735207
96	Broad-based gait (HP:0002136)	1.59873717
97	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.59682028
98	Type II lissencephaly (HP:0007260)	1.56691767
99	Optic nerve hypoplasia (HP:0000609)	1.56321160
100	Aplasia/Hypoplasia of the hallux (HP:0008362)	1.56189347

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.91840760
2	GRK1	3.24213794
3	WNK3	3.09693895
4	ADRBK2	2.96630896
5	TAOK3	2.96321971
6	MAP4K2	2.88048952
7	MAPK15	2.68089253
8	PINK1	2.54672559
9	WNK4	2.38910784
10	TLK1	2.22700228
11	BMPR1B	2.18435460
12	MST4	1.96530586
13	CASK	1.92797529
14	NUAK1	1.92542992
15	TXK	1.84179294
16	ZAK	1.78894470
17	STK39	1.75549365
18	MAPK13	1.66393102
19	ACVR1B	1.60979452
20	STK16	1.48559119
21	OXSR1	1.47718334
22	MAP3K4	1.42217572
23	INSRR	1.40385903
24	DYRK2	1.36498106
25	BCKDK	1.30539009
26	VRK2	1.23754860
27	CCNB1	1.19524640
28	MUSK	1.18804408
29	BRSK2	1.14553734
30	STK38L	1.09734392
31	MAP2K7	1.04749741
32	PNCK	1.04724929
33	ADRBK1	1.03485340
34	PTK2B	0.98759697
35	PLK2	0.98547859
36	TRIM28	0.95182785
37	NME1	0.92174609
38	PAK3	0.89342672
39	TIE1	0.82692941
40	PRKCE	0.82444421
41	PLK4	0.82324977
42	TNK2	0.81803783
43	BCR	0.81494321
44	MAPKAPK3	0.81279011
45	MARK1	0.79885849
46	NEK2	0.79459767
47	PRKCG	0.77256296
48	CSNK1G2	0.76538886
49	VRK1	0.71485202
50	PRKCQ	0.71063058
51	CSNK1G1	0.67478224
52	TNIK	0.67128721
53	PIK3CA	0.66967491
54	ERBB2	0.66580973
55	CAMKK2	0.64558960
56	STK24	0.63454700
57	CAMK2A	0.62205225
58	MAPKAPK5	0.60459157
59	CAMK1	0.60402564
60	PRKACA	0.57685607
61	DAPK2	0.56736782
62	MKNK2	0.55798362
63	DYRK3	0.55724744
64	TEC	0.55403108
65	CSNK1A1	0.51755507
66	PKN1	0.49373772
67	CDK19	0.49263621
68	CSNK1G3	0.49027090
69	GRK7	0.48155727
70	RPS6KA5	0.48111720
71	PRKCI	0.47970262
72	PRKD2	0.47030241
73	ERBB3	0.45101767
74	STK3	0.44498106
75	IKBKB	0.43453411
76	NTRK2	0.43378698
77	PRKCA	0.43269759
78	PLK1	0.42420776
79	PHKG1	0.40810200
80	PHKG2	0.40810200
81	ATR	0.40414497
82	TAF1	0.36805237
83	SGK1	0.36347013
84	NTRK3	0.35792545
85	EIF2AK3	0.35474572
86	CDK3	0.34064758
87	TGFBR1	0.32497855
88	EPHA4	0.32432888
89	ITK	0.32098798
90	IGF1R	0.32035382
91	OBSCN	0.31285206
92	CSNK1A1L	0.30454955
93	FER	0.29800841
94	STK11	0.27765233
95	MAP3K7	0.27741685
96	PRKAA2	0.27323637
97	EPHB2	0.26794037
98	CSNK1D	0.26733732
99	GRK5	0.26703668
100	CHEK2	0.26572816

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.69880242
2	Oxidative phosphorylation_Homo sapiens_hsa00190	2.61390430
3	Linoleic acid metabolism_Homo sapiens_hsa00591	2.53656386
4	Phototransduction_Homo sapiens_hsa04744	2.39716095
5	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.34726709
6	Chemical carcinogenesis_Homo sapiens_hsa05204	2.24353538
7	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.17217473
8	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.10506124
9	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.07370545
10	Huntingtons disease_Homo sapiens_hsa05016	2.02266642
11	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.96337932
12	Nicotine addiction_Homo sapiens_hsa05033	1.92445214
13	Tryptophan metabolism_Homo sapiens_hsa00380	1.86617284
14	Parkinsons disease_Homo sapiens_hsa05012	1.86063535
15	Nitrogen metabolism_Homo sapiens_hsa00910	1.84370665
16	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.82016347
17	Butanoate metabolism_Homo sapiens_hsa00650	1.77103121
18	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.73095439
19	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.73027459
20	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.70214527
21	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.66578484
22	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.66417759
23	Histidine metabolism_Homo sapiens_hsa00340	1.65348454
24	Caffeine metabolism_Homo sapiens_hsa00232	1.64938991
25	Retinol metabolism_Homo sapiens_hsa00830	1.63070054
26	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.56729207
27	beta-Alanine metabolism_Homo sapiens_hsa00410	1.56604887
28	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.55782017
29	Homologous recombination_Homo sapiens_hsa03440	1.51995681
30	Basal transcription factors_Homo sapiens_hsa03022	1.50374015
31	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.48765384
32	Alzheimers disease_Homo sapiens_hsa05010	1.39218023
33	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.32571168
34	Ether lipid metabolism_Homo sapiens_hsa00565	1.31653426
35	Cardiac muscle contraction_Homo sapiens_hsa04260	1.31285572
36	Fanconi anemia pathway_Homo sapiens_hsa03460	1.30467210
37	Protein export_Homo sapiens_hsa03060	1.29084454
38	RNA polymerase_Homo sapiens_hsa03020	1.28911136
39	Olfactory transduction_Homo sapiens_hsa04740	1.28759095
40	Peroxisome_Homo sapiens_hsa04146	1.24712797
41	Taste transduction_Homo sapiens_hsa04742	1.22100555
42	Propanoate metabolism_Homo sapiens_hsa00640	1.19998549
43	Selenocompound metabolism_Homo sapiens_hsa00450	1.19759399
44	Glycerolipid metabolism_Homo sapiens_hsa00561	1.16453642
45	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.16069493
46	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.11570050
47	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.02659058
48	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.00685274
49	ABC transporters_Homo sapiens_hsa02010	0.97823017
50	Tyrosine metabolism_Homo sapiens_hsa00350	0.97325563
51	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.95439950
52	Glutathione metabolism_Homo sapiens_hsa00480	0.93852429
53	Morphine addiction_Homo sapiens_hsa05032	0.92743829
54	Ribosome_Homo sapiens_hsa03010	0.92685161
55	Fat digestion and absorption_Homo sapiens_hsa04975	0.90291396
56	Serotonergic synapse_Homo sapiens_hsa04726	0.89317134
57	Salivary secretion_Homo sapiens_hsa04970	0.86994002
58	Glutamatergic synapse_Homo sapiens_hsa04724	0.85540873
59	RNA degradation_Homo sapiens_hsa03018	0.84213056
60	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.83953167
61	Collecting duct acid secretion_Homo sapiens_hsa04966	0.82716131
62	Fatty acid degradation_Homo sapiens_hsa00071	0.77678974
63	Metabolic pathways_Homo sapiens_hsa01100	0.76363682
64	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.73342073
65	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.69128667
66	Circadian entrainment_Homo sapiens_hsa04713	0.68139040
67	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.67997758
68	Steroid biosynthesis_Homo sapiens_hsa00100	0.67377794
69	Sulfur metabolism_Homo sapiens_hsa00920	0.66387246
70	Calcium signaling pathway_Homo sapiens_hsa04020	0.66250644
71	Phenylalanine metabolism_Homo sapiens_hsa00360	0.65429810
72	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.65087244
73	Basal cell carcinoma_Homo sapiens_hsa05217	0.65025081
74	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.64678410
75	Insulin secretion_Homo sapiens_hsa04911	0.59867262
76	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.59697590
77	Purine metabolism_Homo sapiens_hsa00230	0.57085536
78	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.56304441
79	Pyruvate metabolism_Homo sapiens_hsa00620	0.53142239
80	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.51771276
81	GABAergic synapse_Homo sapiens_hsa04727	0.49860828
82	Proteasome_Homo sapiens_hsa03050	0.49818317
83	Pyrimidine metabolism_Homo sapiens_hsa00240	0.48155639
84	Primary immunodeficiency_Homo sapiens_hsa05340	0.47786131
85	Nucleotide excision repair_Homo sapiens_hsa03420	0.46604412
86	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.45550730
87	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.45286477
88	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.44599387
89	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.41385121
90	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.41374436
91	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.40418145
92	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.39239675
93	Regulation of autophagy_Homo sapiens_hsa04140	0.38379758
94	Circadian rhythm_Homo sapiens_hsa04710	0.38309680
95	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.38255912
96	cAMP signaling pathway_Homo sapiens_hsa04024	0.36615630
97	Mineral absorption_Homo sapiens_hsa04978	0.35068691
98	PPAR signaling pathway_Homo sapiens_hsa03320	0.34506532
99	Melanoma_Homo sapiens_hsa05218	0.33662029
100	One carbon pool by folate_Homo sapiens_hsa00670	0.32242230

C10ORF67

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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