ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	skeletal muscle contraction (GO:0003009)	9.67998763
2	regulation of skeletal muscle contraction (GO:0014819)	9.42627625
3	regulation of relaxation of muscle (GO:1901077)	8.38609678
4	myofibril assembly (GO:0030239)	7.79663256
5	striated muscle contraction (GO:0006941)	7.65778812
6	actin filament-based movement (GO:0030048)	7.64265308
7	sarcomere organization (GO:0045214)	7.62810358
8	positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)	7.41235656
9	creatine metabolic process (GO:0006600)	7.11872882
10	response to stimulus involved in regulation of muscle adaptation (GO:0014874)	6.98695642
11	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)	6.91337013
12	response to muscle activity (GO:0014850)	6.78111986
13	cardiac myofibril assembly (GO:0055003)	6.37713055
14	response to inactivity (GO:0014854)	6.30463724
15	skeletal muscle fiber development (GO:0048741)	6.13653339
16	cardiac muscle contraction (GO:0060048)	6.11498105
17	muscle contraction (GO:0006936)	5.77389729
18	skeletal muscle adaptation (GO:0043501)	5.69795919
19	regulation of actin filament-based movement (GO:1903115)	5.64576468
20	actomyosin structure organization (GO:0031032)	5.64277653
21	myotube cell development (GO:0014904)	5.62683701
22	regulation of cell communication by electrical coupling (GO:0010649)	5.51846454
23	regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)	5.47789036
24	negative regulation of potassium ion transmembrane transporter activity (GO:1901017)	5.32864839
25	glycogen catabolic process (GO:0005980)	5.27538804
26	cardiac muscle hypertrophy (GO:0003300)	5.22106953
27	plasma membrane repair (GO:0001778)	5.19699888
28	NADH metabolic process (GO:0006734)	5.18823683
29	muscle system process (GO:0003012)	5.16467169
30	striated muscle hypertrophy (GO:0014897)	4.97472517
31	glucan catabolic process (GO:0009251)	4.95764552
32	muscle fiber development (GO:0048747)	4.85339400
33	negative regulation of potassium ion transmembrane transport (GO:1901380)	4.77244352
34	glucan biosynthetic process (GO:0009250)	4.75161103
35	glycogen biosynthetic process (GO:0005978)	4.75161103
36	cellular polysaccharide catabolic process (GO:0044247)	4.65141082
37	skeletal muscle tissue development (GO:0007519)	4.61340787
38	striated muscle adaptation (GO:0014888)	4.58960176
39	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO	4.49214913
40	muscle hypertrophy (GO:0014896)	4.44148374
41	muscle tissue morphogenesis (GO:0060415)	4.40693162
42	adult heart development (GO:0007512)	4.33985005
43	regulation of striated muscle contraction (GO:0006942)	4.33792753
44	cardiac muscle tissue morphogenesis (GO:0055008)	4.33507274
45	regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)	4.31399545
46	regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)	4.24612910
47	polysaccharide catabolic process (GO:0000272)	4.18757636
48	2-oxoglutarate metabolic process (GO:0006103)	4.17162312
49	skeletal muscle tissue regeneration (GO:0043403)	4.16912293
50	muscle cell cellular homeostasis (GO:0046716)	4.15587952
51	carnitine shuttle (GO:0006853)	4.10341323
52	positive regulation of calcium ion transmembrane transporter activity (GO:1901021)	4.09166052
53	cardiac muscle cell development (GO:0055013)	4.06921722
54	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	3.98463990
55	striated muscle cell development (GO:0055002)	3.96962963
56	tricarboxylic acid cycle (GO:0006099)	3.91816299
57	regulation of the force of heart contraction (GO:0002026)	3.91586193
58	regulation of calcium ion transmembrane transporter activity (GO:1901019)	3.84969894
59	regulation of calcium ion transmembrane transport (GO:1903169)	3.84969894
60	glycogen metabolic process (GO:0005977)	3.82863119
61	muscle structure development (GO:0061061)	3.77292115
62	cardiac cell development (GO:0055006)	3.77235069
63	muscle organ development (GO:0007517)	3.76272218
64	fructose metabolic process (GO:0006000)	3.76207554
65	glucan metabolic process (GO:0044042)	3.75212534
66	cellular glucan metabolic process (GO:0006073)	3.75212534
67	cardiac muscle hypertrophy in response to stress (GO:0014898)	3.72739144
68	muscle hypertrophy in response to stress (GO:0003299)	3.72739144
69	cardiac muscle adaptation (GO:0014887)	3.72739144
70	positive regulation of myotube differentiation (GO:0010831)	3.72025321
71	striated muscle atrophy (GO:0014891)	3.71932810
72	muscle cell fate commitment (GO:0042693)	3.71069430
73	muscle adaptation (GO:0043500)	3.70392736
74	muscle organ morphogenesis (GO:0048644)	3.68403377
75	gluconeogenesis (GO:0006094)	3.67539308
76	negative regulation of calcium ion transmembrane transporter activity (GO:1901020)	3.65064615
77	negative regulation of calcium ion transmembrane transport (GO:1903170)	3.65064615
78	response to activity (GO:0014823)	3.64773949
79	heart process (GO:0003015)	3.64761834
80	heart contraction (GO:0060047)	3.64761834
81	fatty acid transmembrane transport (GO:1902001)	3.47865840
82	regulation of membrane repolarization (GO:0060306)	3.45106132
83	regulation of sequestering of triglyceride (GO:0010889)	3.40966286
84	muscle cell development (GO:0055001)	3.40564729
85	positive regulation of cation channel activity (GO:2001259)	3.39359507
86	muscle atrophy (GO:0014889)	3.35107191
87	relaxation of muscle (GO:0090075)	3.34930978
88	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	3.32515766
89	myoblast fusion (GO:0007520)	3.31921432
90	regulation of muscle system process (GO:0090257)	3.29492561
91	hexose biosynthetic process (GO:0019319)	3.26905211
92	striated muscle tissue development (GO:0014706)	3.26597333
93	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.25553743
94	regulation of myoblast differentiation (GO:0045661)	3.25066410
95	positive regulation of mitochondrial calcium ion concentration (GO:0051561)	3.20586977
96	regulation of muscle contraction (GO:0006937)	3.19389642
97	actin-myosin filament sliding (GO:0033275)	12.5581297
98	muscle filament sliding (GO:0030049)	12.5581297
99	sarcoplasmic reticulum calcium ion transport (GO:0070296)	11.1518061
100	actin-mediated cell contraction (GO:0070252)	10.3245347

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	6.67453141
2	EZH2_22144423_ChIP-Seq_EOC_Human	5.24924890
3	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.31880688
4	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.09421458
5	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	3.50091641
6	TBX20_22328084_ChIP-Seq_HEART_Mouse	3.15732431
7	TBX20_22080862_ChIP-Seq_HEART_Mouse	3.15732431
8	EP300_21415370_ChIP-Seq_HL-1_Mouse	2.91559939
9	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	2.86240522
10	ESR1_20079471_ChIP-ChIP_T-47D_Human	2.84915686
11	CDX2_19796622_ChIP-Seq_MESCs_Mouse	2.79130000
12	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	2.62197496
13	MEF2A_21415370_ChIP-Seq_HL-1_Mouse	2.50577204
14	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.41677318
15	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.34049794
16	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.32603854
17	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	2.21041785
18	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	2.10349965
19	GATA4_21415370_ChIP-Seq_HL-1_Mouse	1.90876403
20	NKX2-5_21415370_ChIP-Seq_HL-1_Mouse	1.78021066
21	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.68470554
22	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.55453862
23	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.44704822
24	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.39994546
25	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.39442226
26	NFIB_24661679_ChIP-Seq_LUNG_Mouse	1.37986795
27	* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.36964830
28	CTCF_27219007_Chip-Seq_Bcells_Human	1.33489563
29	ZNF263_19887448_ChIP-Seq_K562_Human	1.33226987
30	DROSHA_22980978_ChIP-Seq_HELA_Human	1.29649178
31	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.28102388
32	IGF1R_20145208_ChIP-Seq_DFB_Human	1.26750027
33	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.26454410
34	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.22592336
35	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.20992183
36	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.13822634
37	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.11388922
38	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.11335795
39	GBX2_23144817_ChIP-Seq_PC3_Human	1.10886555
40	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	1.07540061
41	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.07209050
42	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.05731062
43	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.05563183
44	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.04261293
45	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.03790752
46	SMC3_22415368_ChIP-Seq_MEFs_Mouse	1.02964911
47	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.02627401
48	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.02342385
49	OCT4_20526341_ChIP-Seq_ESCs_Human	1.01918845
50	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.00926725
51	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.00051735
52	PPARA_22158963_ChIP-Seq_LIVER_Mouse	0.97467388
53	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.96568519
54	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.96026638
55	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.93714106
56	MYC_27129775_Chip-Seq_CORNEA_Mouse	0.93656978
57	* GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.92238567
58	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.92101298
59	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	0.91993332
60	RXR_22158963_ChIP-Seq_LIVER_Mouse	0.91640970
61	LXR_22158963_ChIP-Seq_LIVER_Mouse	0.91321050
62	SPI1_20517297_ChIP-Seq_HL60_Human	0.91065096
63	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	0.91031641
64	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	0.90268486
65	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.90202559
66	GATA1_19941827_ChIP-Seq_MEL_Mouse	0.89914166
67	VDR_22108803_ChIP-Seq_LS180_Human	0.89570097
68	CTCF_21964334_ChIP-Seq_BJAB-B_Human	0.89128700
69	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.85678976
70	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.83752020
71	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.83752020
72	HTT_18923047_ChIP-ChIP_STHdh_Human	0.83138078
73	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.82867940
74	PRDM14_21183938_ChIP-Seq_MESCs_Mouse	0.82857264
75	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.80953131
76	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.78717008
77	CLOCK_20551151_ChIP-Seq_293T_Human	0.78704454
78	SA1_27219007_Chip-Seq_Bcells_Human	0.78660023
79	TRIM28_21343339_ChIP-Seq_HEK293_Human	0.76982672
80	ER_23166858_ChIP-Seq_MCF-7_Human	0.76844592
81	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.76007935
82	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.75840409
83	GATA1_19941827_ChIP-Seq_MEL86_Mouse	0.72414283
84	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.72023720
85	STAT1_20625510_ChIP-Seq_HELA_Human	0.71526569
86	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.69524866
87	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	0.69512854
88	SOX2_19829295_ChIP-Seq_ESCs_Human	0.69494430
89	NANOG_19829295_ChIP-Seq_ESCs_Human	0.69494430
90	* CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.69273453
91	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	0.68980167
92	PHF8_20622853_ChIP-Seq_HELA_Human	0.68918624
93	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	0.68903320
94	CTCF_21964334_Chip-Seq_Bcells_Human	0.68416476
95	GF1_26923725_Chip-Seq_HPCs_Mouse	0.68069238
96	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	0.67951637
97	DNAJC2_21179169_ChIP-ChIP_NT2_Human	0.67457306
98	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.67066183
99	EGR1_19032775_ChIP-ChIP_M12_Human	0.65976405
100	DPY_21335234_ChIP-Seq_ESCs_Mouse	0.65686902

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003646_muscle_fatigue	6.96705109
2	MP0004145_abnormal_muscle_electrophysio	6.55475699
3	MP0000751_myopathy	6.17696716
4	MP0000749_muscle_degeneration	5.69398377
5	MP0004036_abnormal_muscle_relaxation	4.49450859
6	MP0002106_abnormal_muscle_physiology	3.71259205
7	MP0004084_abnormal_cardiac_muscle	3.61252962
8	MP0004087_abnormal_muscle_fiber	3.49987915
9	MP0000747_muscle_weakness	3.46145223
10	MP0000759_abnormal_skeletal_muscle	3.34638187
11	MP0005451_abnormal_body_composition	3.15489966
12	MP0005369_muscle_phenotype	3.13324724
13	MP0002269_muscular_atrophy	3.01980473
14	MP0002332_abnormal_exercise_endurance	3.00719106
15	MP0004130_abnormal_muscle_cell	2.96152507
16	MP0005330_cardiomyopathy	2.90779750
17	MP0005620_abnormal_muscle_contractility	2.90547068
18	MP0000750_abnormal_muscle_regeneration	2.87444930
19	MP0004233_abnormal_muscle_weight	2.85804338
20	MP0002837_dystrophic_cardiac_calcinosis	2.62793626
21	MP0002972_abnormal_cardiac_muscle	2.35552760
22	MP0004215_abnormal_myocardial_fiber	2.28420647
23	MP0000733_abnormal_muscle_development	2.01220869
24	MP0004484_altered_response_of	1.98235330
25	MP0006036_abnormal_mitochondrial_physio	1.91106598
26	MP0002108_abnormal_muscle_morphology	1.90096968
27	MP0004510_myositis	1.80844019
28	MP0010630_abnormal_cardiac_muscle	1.74341377
29	MP0006138_congestive_heart_failure	1.63370376
30	MP0002127_abnormal_cardiovascular_syste	1.59991246
31	MP0005385_cardiovascular_system_phenoty	1.59806792
32	MP0001544_abnormal_cardiovascular_syste	1.59806792
33	MP0000013_abnormal_adipose_tissue	1.52768504
34	MP0005266_abnormal_metabolism	1.40269557
35	MP0004270_analgesia	1.37322955
36	MP0003221_abnormal_cardiomyocyte_apopto	1.30132284
37	MP0008775_abnormal_heart_ventricle	1.22430916
38	MP0003137_abnormal_impulse_conducting	1.21907209
39	MP0005670_abnormal_white_adipose	1.16533814
40	MP0001661_extended_life_span	1.10384366
41	MP0002971_abnormal_brown_adipose	1.09704655
42	MP0003950_abnormal_plasma_membrane	1.05051199
43	MP0004185_abnormal_adipocyte_glucose	0.96309909
44	MP0005666_abnormal_adipose_tissue	0.94313205
45	MP0004085_abnormal_heartbeat	0.91888952
46	MP0005375_adipose_tissue_phenotype	0.89942345
47	MP0002822_catalepsy	0.83140523
48	MP0000003_abnormal_adipose_tissue	0.80635485
49	MP0003828_pulmonary_edema	0.78959078
50	MP0009780_abnormal_chondrocyte_physiolo	0.75385227
51	MP0003045_fibrosis	0.72440391
52	MP0000372_irregular_coat_pigmentation	0.71394814
53	MP0000266_abnormal_heart_morphology	0.68806143
54	MP0004147_increased_porphyrin_level	0.65756592
55	MP0003656_abnormal_erythrocyte_physiolo	0.57618318
56	MP0003879_abnormal_hair_cell	0.55880475
57	MP0001299_abnormal_eye_distance/	0.55379728
58	MP0004134_abnormal_chest_morphology	0.53216104
59	MP0004043_abnormal_pH_regulation	0.50710760
60	MP0002078_abnormal_glucose_homeostasis	0.50091526
61	MP0005165_increased_susceptibility_to	0.49050744
62	MP0002638_abnormal_pupillary_reflex	0.44897205
63	MP0008569_lethality_at_weaning	0.44018815
64	MP0002128_abnormal_blood_circulation	0.43554133
65	MP0005167_abnormal_blood-brain_barrier	0.41201938
66	MP0004142_abnormal_muscle_tone	0.38823873
67	MP0005376_homeostasis/metabolism_phenot	0.37066224
68	MP0005584_abnormal_enzyme/coenzyme_acti	0.36968179
69	MP0009672_abnormal_birth_weight	0.34616436
70	MP0005535_abnormal_body_temperature	0.34476938
71	MP0005452_abnormal_adipose_tissue	0.31929411
72	MP0000230_abnormal_systemic_arterial	0.30930558
73	MP0005083_abnormal_biliary_tract	0.30530770
74	MP0003948_abnormal_gas_homeostasis	0.30520315
75	MP0006035_abnormal_mitochondrial_morpho	0.30435404
76	MP0005334_abnormal_fat_pad	0.29793088
77	MP0000762_abnormal_tongue_morphology	0.29779866
78	MP0002114_abnormal_axial_skeleton	0.29291179
79	MP0005423_abnormal_somatic_nervous	0.29039082
80	MP0005166_decreased_susceptibility_to	0.28497553
81	MP0010030_abnormal_orbit_morphology	0.28135178
82	MP0005332_abnormal_amino_acid	0.26914973
83	MP0005187_abnormal_penis_morphology	0.26831337
84	MP0005319_abnormal_enzyme/_coenzyme	0.25851344
85	MP0001346_abnormal_lacrimal_gland	0.25666313
86	MP0009250_abnormal_appendicular_skeleto	0.25109845
87	MP0002734_abnormal_mechanical_nocicepti	0.24573121
88	MP0002896_abnormal_bone_mineralization	0.23907150
89	MP0002066_abnormal_motor_capabilities/c	0.21105728
90	MP0001943_abnormal_respiration	0.20320436
91	MP0006276_abnormal_autonomic_nervous	0.19205631
92	MP0004924_abnormal_behavior	0.16721900
93	MP0005386_behavior/neurological_phenoty	0.16721900
94	MP0009115_abnormal_fat_cell	0.15514075
95	MP0002067_abnormal_sensory_capabilities	0.13861928
96	MP0000343_altered_response_to	0.13694678
97	MP0003959_abnormal_lean_body	0.13266508
98	MP0002876_abnormal_thyroid_physiology	0.12222986
99	MP0001984_abnormal_olfaction	0.11857653
100	MP0002234_abnormal_pharynx_morphology	0.11565039

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Type 1 muscle fiber predominance (HP:0003803)	8.31178456
2	Exercise-induced myalgia (HP:0003738)	7.97847271
3	Exercise-induced muscle cramps (HP:0003710)	7.47898640
4	Muscle hypertrophy of the lower extremities (HP:0008968)	6.39917010
5	Calf muscle hypertrophy (HP:0008981)	5.82485417
6	Distal arthrogryposis (HP:0005684)	5.62615562
7	Myopathic facies (HP:0002058)	5.62581797
8	EMG: myopathic abnormalities (HP:0003458)	5.48853885
9	Muscle fiber splitting (HP:0003555)	5.09427268
10	Hyporeflexia of lower limbs (HP:0002600)	4.98946356
11	Rhabdomyolysis (HP:0003201)	4.91693852
12	Abnormality of the calf musculature (HP:0001430)	4.88401109
13	Myoglobinuria (HP:0002913)	4.87785024
14	Centrally nucleated skeletal muscle fibers (HP:0003687)	4.71678673
15	Round ear (HP:0100830)	4.60690561
16	Neck muscle weakness (HP:0000467)	4.54854397
17	Rimmed vacuoles (HP:0003805)	4.45984403
18	Abnormality of the left ventricular outflow tract (HP:0011103)	4.40008379
19	Subaortic stenosis (HP:0001682)	4.40008379
20	Ulnar deviation of the wrist (HP:0003049)	4.28940283
21	Abnormality of skeletal muscle fiber size (HP:0012084)	4.26300412
22	Sudden death (HP:0001699)	4.04855802
23	Difficulty running (HP:0009046)	4.03598609
24	Increased connective tissue (HP:0009025)	3.81228189
25	Distal lower limb muscle weakness (HP:0009053)	3.80197866
26	Calcaneovalgus deformity (HP:0001848)	3.76384484
27	Asymmetric septal hypertrophy (HP:0001670)	3.70352571
28	Bundle branch block (HP:0011710)	3.67033362
29	Muscle stiffness (HP:0003552)	3.61128819
30	Increased variability in muscle fiber diameter (HP:0003557)	3.54735777
31	Frequent falls (HP:0002359)	3.48921648
32	Absent phalangeal crease (HP:0006109)	3.43222970
33	Areflexia of lower limbs (HP:0002522)	3.40405413
34	Deformed tarsal bones (HP:0008119)	3.33906809
35	Myotonia (HP:0002486)	3.30214155
36	EMG: neuropathic changes (HP:0003445)	3.28057200
37	Malignant hyperthermia (HP:0002047)	3.02598851
38	Generalized muscle weakness (HP:0003324)	2.96016154
39	Ventricular tachycardia (HP:0004756)	2.95139724
40	Abnormal finger flexion creases (HP:0006143)	2.83983279
41	Mildly elevated creatine phosphokinase (HP:0008180)	2.82534248
42	Dilated cardiomyopathy (HP:0001644)	2.81441258
43	Lipoatrophy (HP:0100578)	2.61582962
44	Distal lower limb amyotrophy (HP:0008944)	2.59148324
45	Bulbar palsy (HP:0001283)	2.56345388
46	Slender build (HP:0001533)	2.47777893
47	Scapular winging (HP:0003691)	2.43061524
48	Weak cry (HP:0001612)	2.40601205
49	Fetal akinesia sequence (HP:0001989)	2.37483742
50	Progressive muscle weakness (HP:0003323)	2.35799521
51	Limb-girdle muscle atrophy (HP:0003797)	2.35753679
52	Gowers sign (HP:0003391)	2.34581703
53	Heart block (HP:0012722)	2.31906189
54	Hyperkalemia (HP:0002153)	2.31245579
55	Fatigable weakness (HP:0003473)	2.21852562
56	Abnormality of the neuromuscular junction (HP:0003398)	2.21852562
57	Spinal rigidity (HP:0003306)	2.19744523
58	Muscular dystrophy (HP:0003560)	2.19724373
59	Abnormality of the foot musculature (HP:0001436)	2.18041847
60	Abnormal atrioventricular conduction (HP:0005150)	2.17113538
61	Proximal amyotrophy (HP:0007126)	2.13677678
62	Abnormality of the calcaneus (HP:0008364)	2.12850298
63	Hip contracture (HP:0003273)	2.12174236
64	Difficulty climbing stairs (HP:0003551)	2.11213342
65	Ragged-red muscle fibers (HP:0003200)	2.05695031
66	Waddling gait (HP:0002515)	2.04611377
67	Ventricular arrhythmia (HP:0004308)	2.01436479
68	Nemaline bodies (HP:0003798)	10.9225762
69	Muscle fiber inclusion bodies (HP:0100299)	10.9221280
70	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	10.5842161
71	Abnormality of the shoulder girdle musculature (HP:0001435)	1.99030606
72	Foot dorsiflexor weakness (HP:0009027)	1.96687510
73	Lower limb amyotrophy (HP:0007210)	1.96304325
74	Exercise intolerance (HP:0003546)	1.84121534
75	Respiratory insufficiency due to muscle weakness (HP:0002747)	1.82347841
76	Abnormality of the hip-girdle musculature (HP:0001445)	1.78651801
77	Abnormality of the musculature of the pelvis (HP:0001469)	1.78651801
78	Shoulder girdle muscle weakness (HP:0003547)	1.71669192
79	Pelvic girdle muscle weakness (HP:0003749)	1.70896697
80	Limb-girdle muscle weakness (HP:0003325)	1.70349359
81	Long clavicles (HP:0000890)	1.68548280
82	Facial diplegia (HP:0001349)	1.66054167
83	Paralysis (HP:0003470)	1.65255542
84	Increased intramyocellular lipid droplets (HP:0012240)	1.63989250
85	Atrial fibrillation (HP:0005110)	1.62658469
86	Nonprogressive disorder (HP:0003680)	1.59778431
87	Increased muscle lipid content (HP:0009058)	1.53033383
88	Ventricular fibrillation (HP:0001663)	1.51209160
89	Popliteal pterygium (HP:0009756)	1.48853292
90	Steppage gait (HP:0003376)	1.48018256
91	Syncope (HP:0001279)	1.47797850
92	Primary atrial arrhythmia (HP:0001692)	1.47371712
93	Atrioventricular block (HP:0001678)	1.46991948
94	Palpitations (HP:0001962)	1.46535525
95	Type 2 muscle fiber atrophy (HP:0003554)	1.45726319
96	Metatarsus adductus (HP:0001840)	1.45489289
97	Ulnar deviation of finger (HP:0009465)	1.44917674
98	Oligomenorrhea (HP:0000876)	1.43292576
99	Supraventricular tachycardia (HP:0004755)	1.42303341
100	Limited hip movement (HP:0008800)	1.42075319

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TTN	6.44010909
2	PHKG2	5.96178279
3	PHKG1	5.96178279
4	PIK3CG	2.74070009
5	PINK1	2.02282432
6	OBSCN	10.9470161
7	MAPK12	1.96622783
8	MUSK	1.75039177
9	MAP3K7	1.70771751
10	MAP2K3	1.68462875
11	DMPK	1.29259589
12	MAPKAPK3	1.28314913
13	TRPM7	1.22561489
14	MARK1	1.20566234
15	MAP2K4	1.12801405
16	NEK1	1.06290535
17	NME1	1.06259650
18	LIMK1	0.98404879
19	EEF2K	0.96856876
20	PRKAA2	0.91294394
21	CAMK2G	0.89840191
22	CCNB1	0.86489625
23	PDK2	0.84325787
24	MOS	0.79779925
25	MAP2K6	0.78403100
26	PRKAA1	0.77362189
27	ERBB3	0.74421354
28	CAMK4	0.69972013
29	NEK9	0.69700718
30	DYRK1B	0.66494992
31	MAPK7	0.66280147
32	CAMK2D	0.66255222
33	BCKDK	0.62573337
34	AKT2	0.60194123
35	PIK3CA	0.57205855
36	RIPK1	0.55518982
37	PKN1	0.55146342
38	PRKG1	0.53687487
39	MAPK4	0.51587135
40	CAMK1	0.50856942
41	CAMK2A	0.50175398
42	MAPK11	0.49516902
43	MAP3K13	0.48936659
44	ROCK1	0.47662420
45	MAP2K1	0.47514170
46	MYLK	0.46180336
47	CAMK2B	0.45935920
48	KSR2	0.44567818
49	TRIB3	0.43805949
50	TIE1	0.42709734
51	SGK3	0.42547681
52	ICK	0.39331151
53	PRKACA	0.35476573
54	SGK2	0.32396163
55	LATS2	0.30695460
56	RPS6KA3	0.28191535
57	PRKD1	0.27304189
58	TBK1	0.25477968
59	PRKACB	0.24593261
60	SGK1	0.24519089
61	MAPK13	0.23548555
62	RPS6KB1	0.23164532
63	RPS6KC1	0.22690017
64	RPS6KL1	0.22690017
65	MAPK10	0.22656997
66	RPS6KA1	0.22033922
67	MAP3K1	0.20236792
68	PRKACG	0.19325246
69	RPS6KA6	0.18557278
70	LATS1	0.18213875
71	PDPK1	0.17696796
72	TAOK2	0.16714586
73	MARK2	0.16653858
74	MAP3K6	0.16051466
75	DAPK2	0.15550862
76	RPS6KB2	0.15107273
77	MARK3	0.14064714
78	EPHA3	0.14059902
79	EPHB1	0.13823370
80	PDK1	0.12696245
81	GRK7	0.12512178
82	SGK223	0.12500238
83	SGK494	0.12500238
84	MTOR	0.12397013
85	PAK3	0.12200206
86	PRPF4B	0.11698981
87	STK11	0.11404512
88	SIK1	0.11295203
89	ZAP70	0.08881411
90	TGFBR2	0.08493363
91	CDC42BPA	0.07902195
92	RAF1	0.07721995
93	MAP3K10	0.04987952
94	KSR1	0.04766957
95	NLK	0.04756642
96	MAPK9	0.04450967
97	ARAF	0.03991936
98	MAP3K5	0.03571393
99	ROCK2	0.02885475
100	GSK3B	0.02880083

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	4.71315297
2	Cardiac muscle contraction_Homo sapiens_hsa04260	4.33374306
3	Dilated cardiomyopathy_Homo sapiens_hsa05414	4.31084592
4	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	4.18470216
5	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	3.99139061
6	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	3.59605540
7	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	3.29077205
8	Circadian rhythm_Homo sapiens_hsa04710	2.56817496
9	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	2.30619757
10	Carbon metabolism_Homo sapiens_hsa01200	2.20315557
11	Glucagon signaling pathway_Homo sapiens_hsa04922	2.14574953
12	Arginine and proline metabolism_Homo sapiens_hsa00330	1.99599560
13	Insulin signaling pathway_Homo sapiens_hsa04910	1.94345765
14	Arginine biosynthesis_Homo sapiens_hsa00220	1.82912680
15	Pentose phosphate pathway_Homo sapiens_hsa00030	1.81040994
16	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.75034374
17	Calcium signaling pathway_Homo sapiens_hsa04020	1.73069053
18	Propanoate metabolism_Homo sapiens_hsa00640	1.70492997
19	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.68250120
20	Parkinsons disease_Homo sapiens_hsa05012	1.61882270
21	Insulin resistance_Homo sapiens_hsa04931	1.59339625
22	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.59160802
23	Pyruvate metabolism_Homo sapiens_hsa00620	1.58468222
24	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.56823054
25	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.52679184
26	Alzheimers disease_Homo sapiens_hsa05010	1.49059478
27	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.43719975
28	Fatty acid degradation_Homo sapiens_hsa00071	1.41330268
29	AMPK signaling pathway_Homo sapiens_hsa04152	1.26449159
30	Oxidative phosphorylation_Homo sapiens_hsa00190	1.23861529
31	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.21621302
32	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.19486997
33	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.19324725
34	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.17945763
35	Adipocytokine signaling pathway_Homo sapiens_hsa04920	1.15217657
36	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.15033944
37	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.08280687
38	Phenylalanine metabolism_Homo sapiens_hsa00360	1.05424934
39	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.04953638
40	Fatty acid metabolism_Homo sapiens_hsa01212	0.96653080
41	Nitrogen metabolism_Homo sapiens_hsa00910	0.95232161
42	Gastric acid secretion_Homo sapiens_hsa04971	0.93081752
43	Renin secretion_Homo sapiens_hsa04924	0.91095131
44	Viral myocarditis_Homo sapiens_hsa05416	0.82978561
45	Tight junction_Homo sapiens_hsa04530	0.79618377
46	GnRH signaling pathway_Homo sapiens_hsa04912	0.74387116
47	Huntingtons disease_Homo sapiens_hsa05016	0.72983477
48	Galactose metabolism_Homo sapiens_hsa00052	0.67452824
49	Long-term potentiation_Homo sapiens_hsa04720	0.67242622
50	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.66186606
51	Insulin secretion_Homo sapiens_hsa04911	0.65902071
52	Butanoate metabolism_Homo sapiens_hsa00650	0.63758724
53	PPAR signaling pathway_Homo sapiens_hsa03320	0.61110605
54	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.56686991
55	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.55989874
56	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.52315364
57	Fatty acid elongation_Homo sapiens_hsa00062	0.52265205
58	Circadian entrainment_Homo sapiens_hsa04713	0.52031209
59	Focal adhesion_Homo sapiens_hsa04510	0.51883830
60	beta-Alanine metabolism_Homo sapiens_hsa00410	0.50815673
61	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.49518636
62	FoxO signaling pathway_Homo sapiens_hsa04068	0.49299927
63	Tryptophan metabolism_Homo sapiens_hsa00380	0.47299935
64	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.45526227
65	Salivary secretion_Homo sapiens_hsa04970	0.42192653
66	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.38969751
67	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.37648519
68	Peroxisome_Homo sapiens_hsa04146	0.36599247
69	cAMP signaling pathway_Homo sapiens_hsa04024	0.35678793
70	MAPK signaling pathway_Homo sapiens_hsa04010	0.35608113
71	Lysine degradation_Homo sapiens_hsa00310	0.35385362
72	Cholinergic synapse_Homo sapiens_hsa04725	0.33853304
73	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.32294759
74	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.30618978
75	Long-term depression_Homo sapiens_hsa04730	0.30569467
76	Regulation of autophagy_Homo sapiens_hsa04140	0.29692380
77	Pancreatic secretion_Homo sapiens_hsa04972	0.26574773
78	Tyrosine metabolism_Homo sapiens_hsa00350	0.25688941
79	mTOR signaling pathway_Homo sapiens_hsa04150	0.25346981
80	Histidine metabolism_Homo sapiens_hsa00340	0.24266981
81	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.24134080
82	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.22197365
83	Platelet activation_Homo sapiens_hsa04611	0.22165357
84	Amphetamine addiction_Homo sapiens_hsa05031	0.22025546
85	VEGF signaling pathway_Homo sapiens_hsa04370	0.18993364
86	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.18721873
87	Purine metabolism_Homo sapiens_hsa00230	0.18424572
88	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.15363728
89	Adherens junction_Homo sapiens_hsa04520	0.14977013
90	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.14907592
91	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.14578185
92	Olfactory transduction_Homo sapiens_hsa04740	0.13858943
93	Bile secretion_Homo sapiens_hsa04976	0.12550551
94	Melanogenesis_Homo sapiens_hsa04916	0.12087994
95	Amoebiasis_Homo sapiens_hsa05146	0.10918041
96	Glioma_Homo sapiens_hsa05214	0.10455348
97	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.10385503
98	Oocyte meiosis_Homo sapiens_hsa04114	0.08218180
99	Metabolic pathways_Homo sapiens_hsa01100	0.08166354
100	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.07806467

C10ORF71

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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